Base de dados : MEDLINE
Pesquisa : G07.203.300 [Categoria DeCS]
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[PMID]:27770709
[Au] Autor:Wang B; Chen Q; Shen L; Zhao S; Pang W; Zhang J
[Ad] Endereço:MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
[Ti] Título:Perfluoroalkyl and polyfluoroalkyl substances in cord blood of newborns in Shanghai, China: Implications for risk assessment.
[So] Source:Environ Int;97:7-14, 2016 12.
[Is] ISSN:1873-6750
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are commonly used in industrial applications and consumer products, and their potential health impacts are of concern, especially for vulnerable population like fetuses. However, in utero exposure to PFASs and health implications are far from fully characterized in China. To fill in the gap, we analyzed 10 PFASs in cord plasma samples (N=687) collected in Shanghai between 2011 and 2012, one of the regions widely polluted with PFASs in China. A questionnaire survey on maternal and diet-related factors was conducted. Except for perfluoroheptanoic acid (PFHpA) and perfluorooctane sulfonamide (PFOSA), all other PFASs were detected in ˃90% of the samples. Perfluorooctanoic acid (PFOA) was the most predominant PFAS (median value: 6.96ng/mL), followed by perfluorooctane sulfonate (PFOS) (2.48ng/mL). PFOA and PFOS combined contributed to 80% of the total PFASs. The final multiple regression models showed that maternal factors including maternal age, body mass index, gestational age, economic status and educational level as well as consumption of fish and wheat were significantly related with concentrations of PFASs in cord blood. The risk assessment using the hazard quotients (HQs) approach on the basis of plasma PFAS levels indicated no potential concern for developmental toxicity in the local newborns. The results demonstrate the unique profiles of local prenatal exposure to PFASs, suggesting that PFOA has been the primary human exposure due to its widespread use and pollution. Special attention to high PFOA exposure and confirmation of potential determinants should be taken as a priority in the future plan for risk management and actions in this area.
[Mh] Termos MeSH primário: Poluentes Ambientais/sangue
Sangue Fetal/química
Hidrocarbonetos Fluorados/sangue
[Mh] Termos MeSH secundário: Animais
China
Feminino
Peixes
Alimentos
Seres Humanos
Gravidez
Medição de Risco
Sulfonamidas/sangue
Ácidos Sulfônicos/sangue
Inquéritos e Questionários
Triticum
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Hydrocarbons, Fluorinated); 0 (Sulfonamides); 0 (Sulfonic Acids)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180311
[Lr] Data última revisão:
180311
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


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[PMID]:28466068
[Au] Autor:McMurray MS; Conway SM; Roitman JD
[Ad] Endereço:Department of Psychology, Miami University, Oxford, OH 45056.
[Ti] Título:Brain Stimulation Reward Supports More Consistent and Accurate Rodent Decision-Making than Food Reward.
[So] Source:eNeuro;4(2), 2017 Mar-Apr.
[Is] ISSN:2373-2822
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Animal models of decision-making rely on an animal's motivation to decide and its ability to detect differences among various alternatives. Food reinforcement, although commonly used, is associated with problematic confounds, especially satiety. Here, we examined the use of brain stimulation reward (BSR) as an alternative reinforcer in rodent models of decision-making and compared it with the effectiveness of sugar pellets. The discriminability of various BSR frequencies was compared to differing numbers of sugar pellets in separate free-choice tasks. We found that BSR was more discriminable and motivated greater task engagement and more consistent preference for the larger reward. We then investigated whether rats prefer BSR of varying frequencies over sugar pellets. We found that animals showed either a clear preference for sugar reward or no preference between reward modalities, depending on the frequency of the BSR alternative and the size of the sugar reward. Overall, these results suggest that BSR is an effective reinforcer in rodent decision-making tasks, removing food-related confounds and resulting in more accurate, consistent, and reliable metrics of choice.
[Mh] Termos MeSH primário: Encéfalo/fisiologia
Comportamento de Escolha/fisiologia
Tomada de Decisões/fisiologia
Reforço (Psicologia)
Recompensa
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/fisiologia
Condicionamento Operante/fisiologia
Estimulação Elétrica
Alimentos
Masculino
Motivação/fisiologia
Ratos Long-Evans
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


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[PMID]:28468668
[Au] Autor:Flowers A; Bell-Temin H; Jalloh A; Stevens SM; Bickford PC
[Ad] Endereço:Department of Neurosurgery and Brain Repair, USF Health Morsani College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd., Campus Box MDC-78, Tampa, FL, 33570, USA.
[Ti] Título:Proteomic anaysis of aged microglia: shifts in transcription, bioenergetics, and nutrient response.
[So] Source:J Neuroinflammation;14(1):96, 2017 May 03.
[Is] ISSN:1742-2094
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Age is the primary risk factor for many diseases. As such, age is a critical co-factor for examination in order to understand the progression and potential intervention in disease progression. Studies examining both the phenotype and transcriptome of aged microglia demonstrated a propensity for the development of a pro-inflammatory phenotype. Less well studied is the concomitant blunting of anti-inflammatory aspects of microglial function with age which also impact plasticity and repair in the CNS. METHODS: This study utilizes mass spectrometry-based proteomics to compare primary microglia from young and aged animals. RESULTS: This study revealed alterations in three clusters of inter-related proteins. The three pathways were inflammatory signaling, mitochondrial function, and cellular metabolism. Analysis of these clusters identified the protein rapamycin-insensitive companion of mTOR (RICTOR), a component of the mTORC2 complex, as a novel upstream regulator of several biological functions that are altered with age and potentially linked to phenotype development. A decrease in mTORC2-dependent AKT S473 phosphorylation, as assessed by insulin growth factor (IGF) treatment, was observed in aged microglia. This novel finding was confirmed by genetic manipulation of the microglial cell line. BV2 cells with diminished RICTOR displayed a phenotype that was strikingly similar to that of aged microglia. This finding is particularly relevant as the mTOR pathway already has a number of pharmacological modulators used clinically. CONCLUSIONS: The results suggest that microglia from aged mice show changes in cellular metabolism and energy regulation that might underlie the alterations in inflammatory signaling. Modulation of one pathway identified in our bioinformatic analysis, RICTOR, may provide an avenue by which deleterious aspects of the aging microglia can be attenuated. If successful, this could mean potentially delaying or diminishing the progress of diseases for which progressive inflammation is involved.
[Mh] Termos MeSH primário: Senescência Celular/fisiologia
Metabolismo Energético/fisiologia
Microglia/metabolismo
Mapas de Interação de Proteínas/fisiologia
Proteômica/métodos
Transcrição Genética/fisiologia
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Ácidos Graxos/metabolismo
Alimentos
Glucose/metabolismo
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s12974-017-0840-7


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[PMID]:29390400
[Au] Autor:Tai WP; Nie GJ; Chen MJ; Yaz TY; Guli A; Wuxur A; Huang QQ; Lin ZG; Wu J
[Ad] Endereço:Department of Gastroenterology, Beijing Shijitan Hospital, Capital Medical University, Beijing.
[Ti] Título:Hot food and beverage consumption and the risk of esophageal squamous cell carcinoma: A case-control study in a northwest area in China.
[So] Source:Medicine (Baltimore);96(50):e9325, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study was trying to investigate the association of hot food and beverage consumption and the risk of esophageal squamous cell carcinoma in Hotan, a northwest area of China with high risk of esophageal squmous cell carcinoma. METHODS: A population-based case-control study was designed. For the study, 167 patients diagnosed with esophageal squamous cell carcinoma were selected from Hotan during 2014 to 2015, and 167 community-based controls were selected from the same area, matched with age and sex. Information involved of temperature of food and beverage intake was obtained by face-to-face interview. Logistic regression analyses were performed to investigate the association between temperature of food and beverage intake and the risk of esophageal squamous cell carcinoma. RESULTS: The temperature of the food and beverage consumed by the esophageal squamous cell carcinoma patients was significantly higher than the controls. High temperature of tea, water, and food intake significantly increased the risk of esophageal squamous cell carcinoma by more than 2-fold, with adjusted odds ratio 2.23 (1.45-2.90), 2.13 (1.53-2.66), and 2.98 (1.89-4.12). CONCLUSIONS: Intake of food and beverage with high temperature was positively associated with the incidence of esophageal squamous cell carcinoma in Northwestern China.
[Mh] Termos MeSH primário: Bebidas/efeitos adversos
Carcinoma de Células Escamosas/etiologia
Neoplasias Esofágicas/etiologia
Alimentos/efeitos adversos
Temperatura Alta
[Mh] Termos MeSH secundário: Adulto
Idoso
Carcinoma de Células Escamosas/epidemiologia
Estudos de Casos e Controles
China/epidemiologia
Neoplasias Esofágicas/epidemiologia
Feminino
Seres Humanos
Incidência
Masculino
Meia-Idade
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009325


  5 / 24092 MEDLINE  
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[PMID]:28460778
[Au] Autor:Doaei S; Kalantari N; Mohammadi NK; Tabesh GA; Gholamalizadeh M
[Ad] Endereço:Student's Research Committee, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
[Ti] Título:Macronutrients and the FTO gene expression in hypothalamus; a systematic review of experimental studies.
[So] Source:Indian Heart J;69(2):277-281, 2017 Mar - Apr.
[Is] ISSN:0019-4832
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:The various studies have examined the relationship between FTO gene expression and macronutrients levels. In order to obtain better viewpoint from this interactions, all of existing studies were reviewed systematically. All published papers have been obtained and reviewed using standard and sensitive keywords from databases such as CINAHL, Embase, PubMed, PsycInfo, and the Cochrane, from 1990 to 2016. The results indicated that all of 6 studies that met the inclusion criteria (from a total of 428 published article) found FTO gene expression changes at short-term follow-ups. Four of six studies found an increased FTO gene expression after calorie restriction, while two of them indicated decreased FTO gene expression. The effect of protein, carbohydrate and fat were separately assessed and suggested by all of six studies. In Conclusion, The level of FTO gene expression in hypothalamus is related to macronutrients levels. Future research should evaluate the long-term impact of dietary interventions.
[Mh] Termos MeSH primário: Dioxigenase FTO Dependente de alfa-Cetoglutarato/genética
Doenças Cardiovasculares
Alimentos
Regulação da Expressão Gênica
Predisposição Genética para Doença
Hipotálamo/metabolismo
Obesidade
[Mh] Termos MeSH secundário: Dioxigenase FTO Dependente de alfa-Cetoglutarato/biossíntese
Doenças Cardiovasculares/epidemiologia
Doenças Cardiovasculares/etiologia
Doenças Cardiovasculares/genética
Seres Humanos
Obesidade/complicações
Obesidade/genética
Obesidade/metabolismo
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
EC 1.14.11.33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO); EC 1.14.11.33 (FTO protein, human)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:29422098
[Au] Autor:Huyben D; Boqvist S; Passoth V; Renström L; Allard Bengtsson U; Andréoletti O; Kiessling A; Lundh T; Vågsholm I
[Ad] Endereço:Department of Animal Nutrition and Management, Swedish University of Agricultural Sciences, 75007, Uppsala, Sweden. david.huyben@slu.se.
[Ti] Título:Screening of intact yeasts and cell extracts to reduce Scrapie prions during biotransformation of food waste.
[So] Source:Acta Vet Scand;60(1):9, 2018 Feb 08.
[Is] ISSN:1751-0147
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Yeasts can be used to convert organic food wastes to protein-rich animal feed in order to recapture nutrients. However, the reuse of animal-derived waste poses a risk for the transmission of infectious prions that can cause neurodegeneration and fatality in humans and animals. The aim of this study was to investigate the ability of yeasts to reduce prion activity during the biotransformation of waste substrates-thereby becoming a biosafety hurdle in such a circular food system. During pre-screening, 30 yeast isolates were spiked with Classical Scrapie prions and incubated for 72 h in casein substrate, as a waste substitute. Based on reduced Scrapie seeding activity, waste biotransformation and protease activities, intact cells and cell extracts of 10 yeasts were further tested. Prion analysis showed that five yeast species reduced Scrapie seeding activity by approximately 1 log10 or 90%. Cryptococcus laurentii showed the most potential to reduce prion activity since both intact and extracted cells reduced Scrapie by 1 log10 and achieved the highest protease activity. These results show that select forms of yeast can act as a prion hurdle during the biotransformation of waste. However, the limited ability of yeasts to reduce prion activity warrants caution as a sole barrier to transmission as higher log reductions are needed before using waste-cultured yeast in circular food systems.
[Mh] Termos MeSH primário: Biotransformação
Príons/metabolismo
Scrapie/prevenção & controle
Gerenciamento de Resíduos/métodos
Leveduras/metabolismo
[Mh] Termos MeSH secundário: Animais
Extratos Celulares/análise
Alimentos
Parasitologia de Alimentos/normas
Parasitologia de Alimentos/tendências
Peptídeo Hidrolases/metabolismo
Gerenciamento de Resíduos/normas
Leveduras/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cell Extracts); 0 (Prions); EC 3.4.- (Peptide Hydrolases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE
[do] DOI:10.1186/s13028-018-0363-y


  7 / 24092 MEDLINE  
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[PMID]:29385171
[Au] Autor:Aguayo A; Martin CS; Huddy TF; Ogawa-Okada M; Adkins JL; Steele AD
[Ad] Endereço:Department of Biological Sciences, California State Polytechnic University Pomona, Pomona, CA, United States of America.
[Ti] Título:Sex differences in circadian food anticipatory activity are not altered by individual manipulations of sex hormones or sex chromosome copy number in mice.
[So] Source:PLoS One;13(1):e0191373, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent studies in mice have demonstrated a sexual dimorphism in circadian entrainment to scheduled feeding. On a time restricted diet, males tend to develop food anticipatory activity (FAA) sooner than females and with a higher amplitude of activity. The underlying cause of this sex difference remains unknown. One study suggests that sex hormones, both androgens and estrogens, modulate food anticipatory activity in mice. Here we present results suggesting that the sex difference in FAA is unrelated to gonadal sex hormones. While a sex difference between males and females in FAA on a timed, calorie restricted diet was observed there were no differences between intact and gonadectomized mice in the onset or magnitude of FAA. To test other sources of the sex difference in circadian entrainment to scheduled feeding, we used sex chromosome copy number mutants, but there was no difference in FAA when comparing XX, XY-, XY-;Sry Tg, and XX;Sry Tg mice, demonstrating that gene dosage of sex chromosomes does not mediate the sex difference in FAA. Next, we masculinized female mice by treating them with 17-beta estradiol during the neonatal period; yet again, we saw no difference in FAA between control and masculinized females. Finally, we observed that there was no longer a sex difference in FAA for older mice, suggesting that the sex difference in FAA is age-dependent. Thus, our study demonstrates that singular manipulations of gonadal hormones, sex chromosomes, or developmental patterning are not able to explain the difference in FAA between young male and female mice.
[Mh] Termos MeSH primário: Antecipação Psicológica/fisiologia
Ritmo Circadiano/efeitos dos fármacos
Ritmo Circadiano/genética
Alimentos
Hormônios Esteroides Gonadais/farmacologia
Caracteres Sexuais
Cromossomos Sexuais/genética
[Mh] Termos MeSH secundário: Animais
Antecipação Psicológica/efeitos dos fármacos
Estradiol/farmacologia
Feminino
Dosagem de Genes
Masculino
Camundongos
Camundongos Endogâmicos C57BL
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Gonadal Steroid Hormones); 4TI98Z838E (Estradiol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191373


  8 / 24092 MEDLINE  
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[PMID]:29251972
[Au] Autor:Hutsell BA; Banks ML
[Ad] Endereço:Department of Pharmacology and Toxicology, Virginia Commonwealth University.
[Ti] Título:Remifentanil maintains lower initial delayed nonmatching-to-sample accuracy compared to food pellets in male rhesus monkeys.
[So] Source:Exp Clin Psychopharmacol;25(6):441-447, 2017 12.
[Is] ISSN:1936-2293
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Emerging human laboratory and preclinical drug self-administration data suggest that a history of contingent abused drug exposure impairs performance in operant discrimination procedures, such as delayed nonmatching-to-sample (DNMTS), that are hypothesized to assess components of executive function. However, these preclinical discrimination studies have exclusively used food as the reinforcer and the effects of drugs as reinforcers in these operant procedures are unknown. The present study determined effects of contingent intravenous remifentanil injections on DNMTS performance hypothesized to assess 1 aspect of executive function, working memory. Daily behavioral sessions consisted of 2 components with sequential intravenous remifentanil (0, 0.01-1.0 µg/kg/injection) or food (0, 1-10 pellets) availability in nonopioid dependent male rhesus monkeys (n = 3). Remifentanil functioned as a reinforcer in the DNMTS procedure. Similar delay-dependent DNMTS accuracy was observed under both remifentanil- and food-maintained components, such that higher accuracies were maintained at shorter (0.1-1.0 s) delays and lower accuracies approaching chance performance were maintained at longer (10-32 s) delays. Remifentanil maintained significantly lower initial DNMTS accuracy compared to food. Reinforcer magnitude was not an important determinant of DNMTS accuracy for either remifentanil or food. These results extend the range of experimental procedures under which drugs function as reinforcers. Furthermore, the selective remifentanil-induced decrease in initial DNMTS accuracy is consistent with a selective impairment of attentional, but not memorial, processes. (PsycINFO Database Record
[Mh] Termos MeSH primário: Anestésicos Intravenosos/administração & dosagem
Condicionamento Operante/efeitos dos fármacos
Desvalorização pelo Atraso/efeitos dos fármacos
Discriminação (Psicologia)/efeitos dos fármacos
Piperidinas/administração & dosagem
Esquema de Reforço
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Função Executiva/efeitos dos fármacos
Alimentos
Macaca mulatta
Masculino
Memória de Curto Prazo/efeitos dos fármacos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Anesthetics, Intravenous); 0 (Piperidines); P10582JYYK (remifentanil)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180224
[Lr] Data última revisão:
180224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1037/pha0000154


  9 / 24092 MEDLINE  
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[PMID]:29175931
[Au] Autor:Humm K; Barfield D
[Ad] Endereço:Department of Clinical Science and Services, Royal Veterinary College, Hertfordshire AL9 7TA, UK.
[Ti] Título:Differentiating between food bloat and gastric dilatation and volvulus in dogs.
[So] Source:Vet Rec;181(21):561-562, 2017 11 25.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Dilatação Gástrica
Volvo Intestinal
[Mh] Termos MeSH secundário: Animais
Doenças do Cão
Cães
Alimentos
Volvo Gástrico
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1136/vr.j5449


  10 / 24092 MEDLINE  
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[PMID]:29368464
[Au] Autor:Neswald E
[Ti] Título:Food Fights: Human Experiments in Late Nineteenth-Century Nutrition Physiology.
[So] Source:Clio Med;95:170-93, 2016.
[Is] ISSN:0045-7183
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Experimentação Humana/história
Fenômenos Fisiológicos da Nutrição
Sujeitos da Pesquisa/história
[Mh] Termos MeSH secundário: Alimentos/história
História do Século XIX
Seres Humanos
Estado Nutricional
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM; QIS
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE



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