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[PMID]: 29447176 [Au] Autor: Svefors P; Selling KE; Shaheen R; Khan AI; Persson LÅ; Lindholm L [Ad] Endereço: International Maternal and Child Health, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. [Ti] Título: Cost-effectiveness of prenatal food and micronutrient interventions on under-five mortality and stunting: Analysis of data from the MINIMat randomized trial, Bangladesh. [So] Source: PLoS One;13(2):e0191260, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: INTRODUCTION: Nutrition interventions may have favourable as well as unfavourable effects. The Maternal and Infant Nutrition Interventions in Matlab (MINIMat), with early prenatal food and micronutrient supplementation, reduced infant mortality and were reported to be very cost-effective. However, the multiple micronutrients (MMS) supplement was associated with an increased risk of stunted growth in infancy and early childhood. This unfavourable outcome was not included in the previous cost-effectiveness analysis. The aim of this study is to evaluate whether the MINIMat interventions remain cost-effective in view of both favourable (decreased under-five-years mortality) and unfavourable (increased stunting) outcomes. METHOD: Pregnant women in rural Bangladesh, where food insecurity still is prevalent, were randomized to early (E) or usual (U) invitation to be given food supplementation and daily doses of 30 mg, or 60 mg iron with 400 µg of folic acid, or MMS with 15 micronutrients including 30 mg iron and 400 µg of folic acid. E reduced stunting at 4.5 years compared with U, MMS increased stunting at 4.5 years compared with Fe60, while the combination EMMS reduced infant mortality compared with UFe60. The outcome measure used was disability adjusted life years (DALYs), a measure of overall disease burden that combines years of life lost due to premature mortality (under five-year mortality) and years lived with disability (stunting). Incremental cost effectiveness ratios were calculated using cost data from already published studies. RESULTS: By incrementing UFe60 (standard practice) to EMMS, one DALY could be averted at a cost of US$24. CONCLUSION: When both favourable and unfavourable outcomes were included in the analysis, early prenatal food and multiple micronutrient interventions remained highly cost effective and seem to be meaningful from a public health perspective. [Mh] Termos MeSH primário: Transtornos do Crescimento/etiologia Fenômenos Fisiológicos da Nutrição do Lactente/economia Micronutrientes/uso terapêutico [Mh] Termos MeSH secundário: Adulto Bangladesh/epidemiologia Pré-Escolar Análise Custo-Benefício/métodos Suplementos Nutricionais Feminino Ácido Fólico Abastecimento de Alimentos Transtornos do Crescimento/tratamento farmacológico Transtornos do Crescimento/mortalidade Seres Humanos Lactente Mortalidade Infantil Fenômenos Fisiológicos da Nutrição do Lactente/efeitos dos fármacos Fenômenos Fisiológicos da Nutrição do Lactente/fisiologia Recém-Nascido Ferro Masculino Micronutrientes/administração & dosagem Política Nutricional Gravidez Cuidado Pré-Natal Fenômenos Fisiológicos da Nutrição Pré-Natal Oligoelementos Vitaminas [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Micronutrients); 0 (Trace Elements); 0 (Vitamins); 935E97BOY8 (Folic Acid); E1UOL152H7 (Iron) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180216 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0191260

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[PMID]: 29446273 [Au] Autor: Boyarskaya LA; Vil'ms EA; Turchaninov DV; Bogdashin IV; Erofeev YV [Ti] Título: [Hygienic substantiation of application of functional dairy products in the prevention of macro- and micronutrient deficiency]. [So] Source: Gig Sanit;95(11):1095-9, 2016. [Is] ISSN: 0016-9900 [Cp] País de publicação: Russia (Federation) [La] Idioma: rus [Ab] Resumo: Based on the study of actual nutrition and availability of macroelements there was found that adult population of the city of Omsk was established to refer to the group at risk for the development of micronutrient deficiency associated with low content of a set of essential elements (copper, zinc, calcium, selenium) in the ration, being prior for correction.There was executed the hygienic substantiation developed the fermented acid milk bioproduct of a functional purpose "Bifidin" enriched with micronutrients, prior for the population of the Omsk region. Introduction of this bio-product into the ration allows to effectively correct disorders of the mineral status, that was manifested in a decline in the proportion of patients with insufficiency of calcium (from 37.9 to 24.1%; p = 0.013), copper (from 51.7 to 25.9%; p = 0.004), selenium (from 96.6 to 84.5%; p = 0.026), zinc (from 58.6 to 48.3% of the subjects; p = 0.264). Upon the completion of the prophylactic course (intake "Bifidin" of 200 ml for 60 days), there was noted the gain in the concentration in hair: calcium (by 24.4%; p=0.441), zinc (by 8.0%; p=0.0008), copper (by 8.8%; p < 0.001), selenium (by 41.5%; p < 0.001). There was established the efficacy of the use of bio-product "Bifidin" enriched with micronutrients for the improvement of the structure of nutrition and element status of the adult population of the city of Omsk. There was justified the extensive use of dairy products enriched with micronutrients both for the reduction of the prevalence of microelementoses and the improvement of the nutritional status. [Mh] Termos MeSH primário: Laticínios Deficiências Nutricionais Suplementos Nutricionais Comportamento Alimentar Micronutrientes/análise Oligoelementos/análise [Mh] Termos MeSH secundário: Adulto Deficiências Nutricionais/diagnóstico Deficiências Nutricionais/epidemiologia Deficiências Nutricionais/prevenção & controle Feminino Cabelo/química Seres Humanos Masculino Necessidades Nutricionais/fisiologia Estado Nutricional Serviços Preventivos de Saúde/métodos Sibéria/epidemiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Micronutrients); 0 (Trace Elements) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180216 [St] Status: MEDLINE

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[PMID]: 29367485 [Au] Autor: Umigai N; Murakami K; Shimizu R; Takeda R; Azuma T [Ad] Endereço: Riken Vitamin Co., Ltd. [Ti] Título: Safety Evaluation and Plasma Carotenoid Accumulation in Healthy Adult Subjects after 12 Weeks of Paprika Oleoresin Supplementation. [So] Source: J Oleo Sci;67(2):225-234, 2018 Feb 01. [Is] ISSN: 1347-3352 [Cp] País de publicação: Japan [La] Idioma: eng [Ab] Resumo: Paprika oleoresin is obtained by solvent extraction from Capsicum annuum L. fruits and contains multiple carotenoids, such as capsanthin, ß-carotene, zeaxanthin, and ß-cryptoxanthin, which are considered protective against various diseases. Herein, we investigated the effect of paprika oleoresin supplementation on plasma carotenoid accumulation and evaluated the safety of the oleoresin. We used a double-blinded, placebo-controlled comparative clinical study design and tested the effects of varying doses in healthy adult subjects. In total, 33 subjects were randomly divided into three groups to take capsules containing 0, 20, or 100 mg of paprika oleoresin daily for 12 consecutive weeks. Plasma carotenoid concentrations were measured at 0, 4, 8, and 12 weeks, and the safety of paprika oleoresin capsules was investigated using analyses of blood biochemistry, hematology, and urine contents. In these experiments, ß-cryptoxanthin and zeaxanthin dose-dependently accumulated in plasma within the dose range of the study over 12 consecutive weeks of paprika oleoresin supplementation. Moreover, ß-cryptoxanthin accumulated to higher levels than the other paprika oleoresin carotenoids. In contrast, capsanthin was not detected in plasma before or during the 12-week treatment period. Finally, no adverse events were associated with intake of paprika oleoresin (20 and 100 mg/day) in safety evaluations. Paprika oleoresin is a suitable source of carotenoids, especially ß-cryptoxanthin. [Mh] Termos MeSH primário: Capsicum/química Carotenoides/sangue Suplementos Nutricionais Extratos Vegetais/administração & dosagem Extratos Vegetais/isolamento & purificação [Mh] Termos MeSH secundário: beta-Criptoxantina/sangue Suplementos Nutricionais/efeitos adversos Relação Dose-Resposta a Droga Método Duplo-Cego Extratos Vegetais/efeitos adversos Distribuição Aleatória Segurança Solventes Fatores de Tempo Zeaxantinas/sangue [Pt] Tipo de publicação: CLINICAL STUDY; COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Beta-Cryptoxanthin); 0 (Plant Extracts); 0 (Solvents); 0 (Zeaxanthins); 0 (oleoresins); 36-88-4 (Carotenoids) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180126 [St] Status: MEDLINE [do] DOI: 10.5650/jos.ess17155

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[PMID]: 29296106 [Au] Autor: Seifert JG; Brumet A; St Cyr JA [Ad] Endereço: Movement Science Laboratory, Montana State University, Bozeman, MT USA. [Ti] Título: The influence of D-ribose ingestion and fitness level on performance and recovery. [So] Source: J Int Soc Sports Nutr;14:47, 2017. [Is] ISSN: 1550-2783 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Background: Skeletal muscle adenosine triphosphate (ATP) levels are severely depleted during and following prolonged high intensity exercise. Recovery from these lower ATP levels can take days, which can affect performance on subsequent days of exercise. Untrained individuals often suffer the stress and consequences of acute, repeated bouts of exercise by not having the ability to perform or recovery sufficiently to exercise on subsequent days. Conversely, trained individuals may be able to recover more quickly due to their enhanced metabolic systems. D-Ribose (DR) has been shown to enhance the recovery in ATP; however, it is not known if recovery and performance can be benefitted with DR ingestion. Therefore, this study was designed to determine what influence DR might have on muscular performance, recovery, and metabolism during and following a multi-day exercise regimen. Methods: The study was a double blind, crossover study in 26 healthy subjects compared 10 g/day of DR to 10 g/day of dextrose (DEX, control). All subjects completed 2 days of loading with either DR or DEX, followed by 3 additional days of supplementation and during these 3 days of supplementation, each subject underwent 60 min of high intensity interval exercise in separate daily sessions, which involved cycling (8 min of exercise at 60% and 2 min at 80% VO max), followed by a 2 min power output (PO) test. Subjects were divided into two groups based on peak VO results, lower VO (LVO ) and higher peak VO (HVO ). Results: Mean and peak PO increased significantly from day 1 to day 3 for the DR trial compared to DEX in the LVO group. Rate of perceived exertion (RPE) and creatine kinase (CK) were significantly lower for DR than DEX in the LVO group. No differences in PO, RPE, heart rate, CK, blood urea nitrogen, or glucose were found between either supplement for the HVO group. Conclusion: DR supplementation in the lower VO max group resulted in maintenance in exercise performance, as well as lower levels of RPE and CK. Unlike no observed benefits with DEX supplementation. [Mh] Termos MeSH primário: Trifosfato de Adenosina/metabolismo Limiar Anaeróbio/efeitos dos fármacos Desempenho Atlético/fisiologia Suplementos Nutricionais Músculo Esquelético/efeitos dos fármacos Músculo Esquelético/metabolismo Aptidão Física/fisiologia Ribose/farmacologia [Mh] Termos MeSH secundário: Adulto Limiar Anaeróbio/fisiologia Estudos Cross-Over Método Duplo-Cego Metabolismo Energético/efeitos dos fármacos Feminino Seres Humanos Masculino Fenômenos Fisiológicos da Nutrição Esportiva [Pt] Tipo de publicação: CLINICAL TRIAL; COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 681HV46001 (Ribose); 8L70Q75FXE (Adenosine Triphosphate) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180104 [St] Status: MEDLINE [do] DOI: 10.1186/s12970-017-0205-8

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[PMID]: 29209154 [Au] Autor: Tinsley GM; Hamm MA; Hurtado AK; Cross AG; Pineda JG; Martin AY; Uribe VA; Palmer TB [Ad] Endereço: Energy Balance & Body Composition Laboratory, Musculoskeletal Assessment Laboratory, Department of Kinesiology & Sport Management, Texas Tech University, Box 43011, Lubbock, TX 79409 USA. [Ti] Título: Effects of two pre-workout supplements on concentric and eccentric force production during lower body resistance exercise in males and females: a counterbalanced, double-blind, placebo-controlled trial. [So] Source: J Int Soc Sports Nutr;14:46, 2017. [Is] ISSN: 1550-2783 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Background: Pre-workout supplements purportedly enhance feelings of energy, reduce fatigue and improve exercise performance. The purpose of this study was to examine the performance effects of caffeinated and non-caffeinated multi-ingredient pre-workout supplements. Methods: In a counterbalanced, double-blind, placebo-controlled design, eccentric and concentric force production during lower body resistance exercise on a mechanized squat device were assessed after supplement ingestion. Repetitions-in-reserve/RPE and subjective feelings of energy, focus and fatigue were also examined. Twenty-one resistance-trained adults (12 F, 9 M) completed three conditions in random order: caffeinated supplement, non-caffeinated supplement and placebo. Subjects were not informed of the presence of a placebo condition. Thirty minutes after supplement ingestion, a 3-repetition maximum test and 5 sets of 6 repetitions were completed using the squat device. Each repetition involved 4-s eccentric and concentric phases, and the force signal throughout each repetition was sampled from a load cell contained within the squat device. The scaled and filtered force signals were analyzed using customized software. Repeated measures analysis of variance and appropriate follow-up analyses were utilized to compare dependent variables, and relevant effect sizes (d) were calculated. Results: Supplement or placebo ingestion led to similar subjective responses ( > 0.05). Energy (+8 to 44%; d = 0.3 to 0.8) and focus (+8 to 25%; d = 0.3 to 0.5) were acutely increased by supplement or placebo ingestion and decreased as the exercise session progressed. Fatigue was acutely decreased by supplement or placebo ingestion (-7 to 38%; d = -0.1 to -0.6) and increased as the exercise session progressed. Eccentric and concentric forces were unimproved by supplementation during the exercise sets for both sexes. In the non-caffeinated supplement condition only, maximal eccentric force production was lower during sets 3 to 5, as compared to set 1 ( < 0.05). Effect size data indicated that both the caffeinated and non-caffeinated supplements may contribute to small increases in concentric force production in males (+5 to 20%, d = 0.2 to 0.4 relative to placebo), but not females. Conclusions: As compared to placebo, caffeinated and non-caffeinated multi-ingredient pre-workout supplements failed to improve concentric and eccentric force production. In males, effect size data indicate a possible small benefit of supplementation on concentric force production, although this was not statistically significant. When resistance-trained subjects were unaware of the presence of a placebo, resistance exercise performance was similar regardless of whether a placebo or multi-ingredient supplement was ingested. [Mh] Termos MeSH primário: Cafeína/farmacologia Suplementos Nutricionais Músculo Esquelético/efeitos dos fármacos Músculo Esquelético/fisiologia Treinamento de Resistência [Mh] Termos MeSH secundário: Análise de Variância Método Duplo-Cego Fadiga Feminino Alimentos Formulados Seres Humanos Masculino Resistência Física/efeitos dos fármacos Resistência Física/fisiologia Fatores Sexuais Fenômenos Fisiológicos da Nutrição Esportiva Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 3G6A5W338E (Caffeine) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171207 [St] Status: MEDLINE [do] DOI: 10.1186/s12970-017-0203-x

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[PMID]: 29200983 [Au] Autor: Roberts J; Zinchenko A; Suckling C; Smith L; Johnstone J; Henselmans M [Ad] Endereço: Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, East Road, Cambridge, UK. [Ti] Título: The short-term effect of high versus moderate protein intake on recovery after strength training in resistance-trained individuals. [So] Source: J Int Soc Sports Nutr;14:44, 2017. [Is] ISSN: 1550-2783 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Background: Dietary protein intakes up to 2.9 g.kg .d and protein consumption before and after resistance training may enhance recovery, resulting in hypertrophy and strength gains. However, it remains unclear whether protein quantity or nutrient timing is central to positive adaptations. This study investigated the effect of total dietary protein content, whilst controlling for protein timing, on recovery in resistance trainees. Methods: Fourteen resistance-trained individuals underwent two 10-day isocaloric dietary regimes with a protein content of 1.8 g.kg .d (PRO ) or 2.9 g.kg .d (PRO ) in a randomised, counterbalanced, crossover design. On days 8-10 (T1-T3), participants undertook resistance exercise under controlled conditions, performing 3 sets of squat, bench press and bent-over rows at 80% 1 repetition maximum until volitional exhaustion. Additionally, participants consumed a 0.4 g.kg whey protein concentrate/isolate mix 30 min before and after exercise sessions to standardise protein timing specific to training. Recovery was assessed via daily repetition performance, muscle soreness, bioelectrical impedance phase angle, plasma creatine kinase (CK) and tumor necrosis factor-α (TNF-α). Results: No significant differences were reported between conditions for any of the performance repetition count variables ( > 0.05). However, within PRO only, squat performance total repetition count was significantly lower at T3 (19.7 ± 6.8) compared to T1 (23.0 ± 7.5; = 0.006). Pre and post-exercise CK concentrations significantly increased across test days ( ≤ 0.003), although no differences were reported between conditions. No differences for TNF-α or muscle soreness were reported between dietary conditions. Phase angle was significantly greater at T3 for PRO (8.26 ± 0.82°) compared with PRO (8.08 ± 0.80°; = 0.012). Conclusions: When energy intake and peri-exercise protein intake was controlled for, a short term PRO diet did not improve markers of muscle damage or soreness in comparison to a PRO approach following repeated days of intensive training. Whilst it is therefore likely that moderate protein intakes (1.8 g.kg .d ) may be sufficient for resistance-trained individuals, it is noteworthy that both lower body exercise performance and bioelectrical phase angle were maintained with PRO . Longer term interventions are warranted to determine whether PRO intakes are sufficient during prolonged training periods or when extensive exercise (e.g. training twice daily) is undertaken. [Mh] Termos MeSH primário: Proteínas na Dieta/administração & dosagem Proteínas na Dieta/farmacologia Suplementos Nutricionais Músculo Esquelético/efeitos dos fármacos Músculo Esquelético/fisiologia Treinamento de Resistência Levantamento de Peso [Mh] Termos MeSH secundário: Adulto Estudos Cross-Over Feminino Seres Humanos Masculino Contração Muscular Músculo Esquelético/metabolismo Resistência Física Fenômenos Fisiológicos da Nutrição Esportiva Levantamento de Peso/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Dietary Proteins) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171205 [St] Status: MEDLINE [do] DOI: 10.1186/s12970-017-0201-z

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[PMID]: 29200982 [Au] Autor: Hamarsland H; Nordengen AL; Nyvik Aas S; Holte K; Garthe I; Paulsen G; Cotter M; Børsheim E; Benestad HB; Raastad T [Ad] Endereço: Department of Physical Performance, Norwegian School of Sport Sciences, P.O. Box 4014 Ullevål Stadion, 0806 Oslo, Norway. [Ti] Título: Native whey protein with high levels of leucine results in similar post-exercise muscular anabolic responses as regular whey protein: a randomized controlled trial. [So] Source: J Int Soc Sports Nutr;14:43, 2017. [Is] ISSN: 1550-2783 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Background: Protein intake is essential to maximally stimulate muscle protein synthesis, and the amino acid leucine seems to possess a superior effect on muscle protein synthesis compared to other amino acids. Native whey has higher leucine content and thus a potentially greater anabolic effect on muscle than regular whey (WPC-80). This study compared the acute anabolic effects of ingesting 2 × 20 g of native whey protein, WPC-80 or milk protein after a resistance exercise session. Methods: 24 young resistance trained men and women took part in this double blind, randomized, partial crossover, controlled study. Participants received either WPC-80 and native whey ( = 10), in a crossover design, or milk ( = 12). Supplements were ingested immediately (20 g) and two hours after (20 g) a bout of heavy-load lower body resistance exercise. Blood samples and muscle biopsies were collected to measure plasma concentrations of amino acids by gas-chromatography mass spectrometry, muscle phosphorylation of p70S6K, 4E-BP1 and eEF-2 by immunoblotting, and mixed muscle protein synthesis by use of [ H ]phenylalanine-infusion, gas-chromatography mass spectrometry and isotope-ratio mass spectrometry. Being the main comparison, differences between native whey and WPC-80 were analysed by a one-way ANOVA and comparisons between the whey supplements and milk were analysed by a two-way ANOVA. Results: Native whey increased blood leucine concentrations more than WPC-80 and milk ( < 0.05). Native whey ingestion induced a greater phosphorylation of p70S6K than milk 180 min after exercise ( = 0.03). Muscle protein synthesis rates increased 1-3 h hours after exercise with WPC-80 (0.119%), and 1-5 h after exercise with native whey (0.112%). Muscle protein synthesis rates were higher 1-5 h after exercise with native whey than with milk (0.112% vs. 0.064, = 0.023). Conclusions: Despite higher-magnitude increases in blood leucine concentrations with native whey, it was not superior to WPC-80 concerning effect on muscle protein synthesis and phosphorylation of p70S6K during a 5-h post-exercise period. Native whey increased phosphorylation of p70S6K and muscle protein synthesis rates to a greater extent than milk during the 5-h post exercise period. Trial registration: This study was retrospectively registered at clinicaltrials.gov as NCT02968888. [Mh] Termos MeSH primário: Suplementos Nutricionais Leucina/análise Músculo Esquelético/efeitos dos fármacos Treinamento de Resistência Fenômenos Fisiológicos da Nutrição Esportiva Proteínas do Soro do Leite/química Proteínas do Soro do Leite/farmacologia [Mh] Termos MeSH secundário: Estudos Cross-Over Método Duplo-Cego Feminino Voluntários Saudáveis Seres Humanos Leucina/farmacologia Masculino Proteínas Musculares/biossíntese Músculo Esquelético/fisiologia Biossíntese de Proteínas/efeitos dos fármacos Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Muscle Proteins); 0 (Whey Proteins); GMW67QNF9C (Leucine) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171205 [Cl] Clinical Trial: ClinicalTrial [St] Status: MEDLINE [do] DOI: 10.1186/s12970-017-0202-y

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[PMID]: 29197967 [Au] Autor: Allegri L; Rosignolo F; Mio C; Filetti S; Baldan F; Damante G [Ad] Endereço: Department of Medical Area, University of Udine, 33100, Udine, Italy. [Ti] Título: Effects of nutraceuticals on anaplastic thyroid cancer cells. [So] Source: J Cancer Res Clin Oncol;144(2):285-294, 2018 Feb. [Is] ISSN: 1432-1335 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: PURPOSE: The anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid cancer with a high mortality rate. Since nutraceuticals may exert beneficial effects on tumor biology, here, effects of four of these compounds [resveratrol, genistein, curcumin and epigallocatechin-3-gallate (EGCG)] on ATC cell lines were investigated. METHODS: Two ATC-derived cell lines were used: SW1736 and 8505C. Cell viability and in vitro aggressiveness was tested by MTT and soft agar assays. Apoptosis was investigated by Western Blot, using an anti-cleaved-PARP antibody. mRNA and miRNA levels were quantified by real-time PCR. RESULTS: All tested nutraceuticals caused in both cell lines decrease of cell viability and increase of apoptosis. In contrast, only curcumin reduced in vitro aggressiveness in both SW1736 and 8505C cell lines, while genistein and EGCG determined a reduction of colony formation only in 8505C cells. Effects on genes related to the thyroid-differentiated phenotype were also tested: resveratrol and genistein administration determined the increment of almost all tested mRNAs in both cell lines. Instead curcumin and EGCG treatments had opposite effects in the two cell lines, causing the increment of almost all the mRNAs in 8505C cells and their reduction in SW1736. Finally, effects of nutraceuticals on levels of several miRNAs, known as important in thyroid cancer progression (hsa-miR-221, hsa-miR-222, hsa-miR-21, hsa-miR-146b, hsa-miR-204), were tested. Curcumin induced a strong and significant reduction of all miR analyzed, except for has-miR-204, in both cell lines. CONCLUSIONS: Altogether, our results clearly indicate the anti-cancer proprieties of curcumin, suggesting the promising use of this nutraceutical in ATC treatment. Resveratrol, genistein and EGCG have heterogeneous effects on molecular features of ATC cells. [Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia Suplementos Nutricionais Carcinoma Anaplásico da Tireoide/tratamento farmacológico Neoplasias da Glândula Tireoide/tratamento farmacológico [Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos Catequina/análogos & derivados Catequina/farmacologia Diferenciação Celular/efeitos dos fármacos Processos de Crescimento Celular/efeitos dos fármacos Linhagem Celular Tumoral Curcumina/farmacologia Genisteína/farmacologia Seres Humanos MicroRNAs/biossíntese MicroRNAs/genética Estilbenos/farmacologia Carcinoma Anaplásico da Tireoide/genética Carcinoma Anaplásico da Tireoide/patologia Neoplasias da Glândula Tireoide/genética Neoplasias da Glândula Tireoide/patologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antineoplastic Agents, Phytogenic); 0 (MicroRNAs); 0 (Stilbenes); 8R1V1STN48 (Catechin); BQM438CTEL (epigallocatechin gallate); DH2M523P0H (Genistein); IT942ZTH98 (Curcumin); Q369O8926L (resveratrol) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171204 [St] Status: MEDLINE [do] DOI: 10.1007/s00432-017-2555-7

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[PMID]: 29358154 [Au] Autor: Turner AD; Waack J; Lewis A; Edwards C; Lawton L [Ad] Endereço: Centre for Environment, Fisheries and Aquaculture Science, Barrack Road, The Nothe, Weymouth, Dorset DT4 8UB, United Kingdom. Electronic address: andrew.turner@cefas.co.uk. [Ti] Título: Development and single-laboratory validation of a UHPLC-MS/MS method for quantitation of microcystins and nodularin in natural water, cyanobacteria, shellfish and algal supplement tablet powders. [So] Source: J Chromatogr B Analyt Technol Biomed Life Sci;1074-1075:111-123, 2018 Feb 01. [Is] ISSN: 1873-376X [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: A simple, rapid UHPLC-MS/MS method has been developed and optimised for the quantitation of microcystins and nodularin in wide variety of sample matrices. Microcystin analogues targeted were MC-LR, MC-RR, MC-LA, MC-LY, MC-LF, LC-LW, MC-YR, MC-WR, [Asp3] MC-LR, [Dha7] MC-LR, MC-HilR and MC-HtyR. Optimisation studies were conducted to develop a simple, quick and efficient extraction protocol without the need for complex pre-analysis concentration procedures, together with a rapid sub 5min chromatographic separation of toxins in shellfish and algal supplement tablet powders, as well as water and cyanobacterial bloom samples. Validation studies were undertaken on each matrix-analyte combination to the full method performance characteristics following international guidelines. The method was found to be specific and linear over the full calibration range. Method sensitivity in terms of limits of detection, quantitation and reporting were found to be significantly improved in comparison to LC-UV methods and applicable to the analysis of each of the four matrices. Overall, acceptable recoveries were determined for each of the matrices studied, with associated precision and within-laboratory reproducibility well within expected guidance limits. Results from the formalised ruggedness analysis of all available cyanotoxins, showed that the method was robust for all parameters investigated. The results presented here show that the optimised LC-MS/MS method for cyanotoxins is fit for the purpose of detection and quantitation of a range of microcystins and nodularin in shellfish, algal supplement tablet powder, water and cyanobacteria. The method provides a valuable early warning tool for the rapid, routine extraction and analysis of natural waters, cyanobacterial blooms, algal powders, food supplements and shellfish tissues, enabling monitoring labs to supplement traditional microscopy techniques and report toxicity results within a short timeframe of sample receipt. The new method, now accredited to ISO17025 standard, is simple, quick, applicable to multiple matrices and is highly suitable for use as a routine, high-throughout, fast turnaround regulatory monitoring tool. [Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos Cianobactérias/química Suplementos Nutricionais/análise Microcistinas/análise Peptídeos Cíclicos/análise Frutos do Mar/análise [Mh] Termos MeSH secundário: Animais Produtos Biológicos/análise Produtos Biológicos/química Bivalves Contaminação de Alimentos Limite de Detecção Modelos Lineares Reprodutibilidade dos Testes Comprimidos Espectrometria de Massas em Tandem/métodos Poluentes Químicos da Água/análise [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biological Products); 0 (Microcystins); 0 (Peptides, Cyclic); 0 (Tablets); 0 (Water Pollutants, Chemical); 0979BIK2QU (nodularin) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180124 [St] Status: MEDLINE

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MEDLINE

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[PMID]: 29351568 [Au] Autor: Sirico F; Miressi S; Castaldo C; Spera R; Montagnani S; Di Meglio F; Nurzynska D [Ad] Endereço: Department of Public Health, University of Naples Federico II, Naples, Italy. [Ti] Título: Habits and beliefs related to food supplements: Results of a survey among Italian students of different education fields and levels. [So] Source: PLoS One;13(1):e0191424, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The increasing availability of food supplements, aggressive media advertising, and common beliefs that these substances have only positive effects on health and sport performance indicate a need for continuous monitoring of this phenomenon. The aim of this study was to investigate the habits and beliefs related to diet supplementation among medical, health professional, and other university/high school students by means of a cross-sectional anonymous survey online. Among the respondents aware of supplements, 37.4% were taking or had taken them in the past. Food supplement use was more common among university students (in particular, those in health professional graduate courses) than high school students. Individual sport practice, rather than team sport, was associated with higher likelihood of food supplement use. Multivitamins were most commonly used, while weight-loss formulations were the least popular. Strikingly, filling nutrient gaps was statistically not considered the main reason for taking food supplements. Instead, they were used to enhance mental performance or enhance well-being. There was statistical evidence that students not enrolled in health or medical professional studies strongly agreed more often than medical students that taking food supplements prevents illness. These results indicate a striking difference between the evidence-based and personal reasons for food supplement use. Arguably, it calls for an improvement in education about diet supplementation and a change in attitude of health care providers to its implementation. [Mh] Termos MeSH primário: Suplementos Nutricionais Conhecimentos, Atitudes e Prática em Saúde [Mh] Termos MeSH secundário: Adolescente Adulto Atitude do Pessoal de Saúde Estudos Transversais Escolaridade Feminino Hábitos Comportamentos Relacionados com a Saúde Pessoal de Saúde/educação Seres Humanos Itália Masculino Esportes Estudantes/psicologia Inquéritos e Questionários Perda de Peso Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180120 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0191424

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