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[PMID]:29275279
[Au] Autor:Chen J; Park B
[Ad] Endereço:United States Department of Agriculture, Agricultural Research Service, U.S. National Poultry Research Center, 950 College Station Rd, Athens, GA 30605, United States.
[Ti] Título:Effect of immunomagnetic bead size on recovery of foodborne pathogenic bacteria.
[So] Source:Int J Food Microbiol;267:1-8, 2018 Feb 21.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Immunomagnetic separation (IMS) as a culture-free enrichment sample preparation technique has gained increasing popularity in the development of rapid detection methods for foodborne pathogens. While the use of magnetic nanoparticles in IMS is on the rise due to substantially larger surface area compared to conventional magnetic microparticles, the effects of immunomagnetic bead (IMB) size on pathogen cell recovery are not fully understood. In this study we used IMBs of different sizes (100, 500, and 1000nm diameters) to capture Salmonella Enteritidis, a common foodborne pathogen, from buffer solutions as well as food matrices (chicken carcass rinse and liquid egg white). The IMS recovery and non-specific binding rate were compared. The recoveries of Salmonella cells in buffers was highest using the 100nm IMBs (88-96%), followed by the 500nm (31-89%) and 1000nm (4.1-61%) IMBs, demonstrating a significant size effect. The non-specific binding rates of E. coli also increased as IMB size decreased. A 2-72% reduction in Salmonella recovery was observed in chicken carcass rinse and liquid egg white samples compared to in buffers, and this reduction was more significant using 500 and 1000nm IMBs. However, lower IMS recoveries (10-56%) was found in 100nm IMBs two months after preparation. Overall, magnetic nanoparticles yielded superior IMS efficiency to micrometer size IMBs and were less subjective to interference from food matrices. Nevertheless, their long term stability remains an obstacle towards successful use in IMS.
[Mh] Termos MeSH primário: Escherichia coli/isolamento & purificação
Microbiologia de Alimentos/métodos
Separação Imunomagnética/instrumentação
Separação Imunomagnética/métodos
Tamanho da Partícula
Salmonella enteritidis/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Galinhas/microbiologia
Clara de Ovo/microbiologia
Microbiologia de Alimentos/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171225
[St] Status:MEDLINE


  2 / 2228 MEDLINE  
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[PMID]:29357364
[Au] Autor:Seraj Z; Seyedarabi A; Saboury AA; Habibi-Rezaei M; Ahmadian S; Ghasemi A
[Ad] Endereço:Department of Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
[Ti] Título:Unraveling the novel effects of aroma from small molecules in preventing hen egg white lysozyme amyloid fibril formation.
[So] Source:PLoS One;13(1):e0189754, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study investigated for the first time the molecular effectiveness of 'aroma' from three small molecules including a phenol (phenyl ethyl alcohol; PEA) and an aldehyde (cinnamaldehyde; Cin) both containing an aromatic ring, and a diamine (N,N,N,N'- Tetramethylethylenediamine; TEMED) at two different amounts (small; S and large; L) in preventing hen egg white lysozyme (HEWL) amyloid fibril formation using Thioflavin T and Nile red fluorescence assays, circular dichroism spectroscopy, SDS-polyacrylamide gel electrophoresis, atomic force microscopy, dynamic light scattering and HEWL activity test. Interestingly, the results revealed that (1) the aroma of PEA, identified as an active constituent of Rosa damascena, prevented fibril formation since PEA-L was able to trap the oligomeric form of HEWL in contrast to PEA-S where protofibrils but not mature fibrils were formed; (2) Cin, previously shown to prevent fibril formation in the liquid form, was also shown to do so in the aroma form by producing protofibrils and not mature fibrils in both Cin- L and Cin-S aroma forms and (3) the aroma of TEMED-L was able to retain HEWL's native structure completely and prevented both aggregation and fibril formation, while TEMED-S prevented HEWL fibril formation and instead directed the pathway towards amorphous aggregate formation. Furthermore, the ability to trap oligomeric species (by PEA-L aroma) is of great importance for further research as it provides routes for preventing the formation of toxic oligomeric intermediates along the fibrillation pathway. Last but not least, the novelty of this in vitro study on the effect of aroma at the molecular level with a unique experimental set-up using HEWL as a model protein in assessing amyloid fibril formation paves the way for more and detailed studies on the importance of aroma producing molecules and their effects.
[Mh] Termos MeSH primário: Amiloide/metabolismo
Clara de Ovo
Muramidase/metabolismo
Odorantes
[Mh] Termos MeSH secundário: Animais
Galinhas
Dicroísmo Circular
Eletroforese em Gel de Poliacrilamida
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amyloid); EC 3.2.1.17 (Muramidase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189754


  3 / 2228 MEDLINE  
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[PMID]:28873618
[Au] Autor:Xu L; Jia F; Luo C; Yu Q; Dai R; Li X
[Ad] Endereço:College of Food Science and Nutritional Engineering, China Agricultural University, 17 Qinghua East Road, Haidian District, Beijing 100083, PR China.
[Ti] Título:Unravelling proteome changes of chicken egg whites under carbon dioxide modified atmosphere packaging.
[So] Source:Food Chem;239:657-663, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Unfertilized chicken eggs within 24h of laying were chosen and stored at 25°C and 45% humidity for 0, 20, and 40days. The experimental group (EG) was the carbon dioxide-modified atmosphere packaging (CDMAP) group, whereas the control group (CG) contained eggs without special handling. Egg freshness indexes were measured. The proteome of the egg whites was determined by LC-MS/MS using isobaric tags for relative and absolute quantitation (iTRAQ). A total of 87 proteins were detected. The results indicated that CDMAP can control the change in protein abundance. Using a correlation analysis between the protein abundance and freshness indexes of the EG, Beta-hexosaminidase, Trypsin inhibitor ClTI-1 and Apolipoprotein D were determined to be potential predictors of egg freshness. In comparing the proteomes of the EG and CG, it was concluded that CDMAP could affect the proteins related to egg vitelline membranes, eggshell matrix and metabolic intensity to maintain egg freshness.
[Mh] Termos MeSH primário: Clara de Ovo
[Mh] Termos MeSH secundário: Animais
Atmosfera
Dióxido de Carbono
Galinhas
Proteoma
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proteome); 142M471B3J (Carbon Dioxide)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  4 / 2228 MEDLINE  
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Vassallo, Dalton Valentim
Texto completo
[PMID]:28987480
[Au] Autor:Rizzetti DA; Martín Á; Corrales P; Fernandez F; Simões MR; Peçanha FM; Vassallo DV; Miguel M; Wiggers GA
[Ad] Endereço:Cardiovascular Physiology Laboratory, Universidade Federal do Pampa, BR 472, Km 592, Uruguaiana, Rio Grande do Sul, Brazil. Electronic address: danize.rizzetti@gmail.com.
[Ti] Título:Egg white-derived peptides prevent cardiovascular disorders induced by mercury in rats: Role of angiotensin-converting enzyme (ACE) and NADPH oxidase.
[So] Source:Toxicol Lett;281:158-174, 2017 Nov 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The study aimed to investigate the effects of egg white hydrolysate (EWH) on vascular disorders induced by mercury (Hg). For this, male Wistar rats were treated for 60days: Untreated (saline, i.m.); Mercury (HgCl , i.m., 1st dose 4.6µg/kg, subsequent doses 0.07µg/kg/day); Hydrolysate (EWH, gavage, 1g/kg/day); Hydrolysate-Mercury. Systolic (SBP) and diastolic (DBP) blood pressure measurement and vascular reactivity experiments in aorta were performed. We analyzed endothelial dependent and independent vasodilator responses and vasoconstrictor response to phenylephrine (Phe) in absence and presence of endothelium, a NOS inhibitor, a NADPH oxidase inhibitor, the superoxide dismutase, a non-selective COX inhibitor, a selective COX-2 inhibitor, an AT-1 receptors blocker. In situ superoxide anion production, SOD-1, NOX-4, p22phox, COX-2 and AT-1 mRNA levels and NOX-1 protein expression were performed in aorta while the determination of angiotensin converting enzyme (ACE) activity was measured in plasma. As results, EWH prevented the increase in SBP and Phe responses and the endothelial dysfunction elicited by Hg, which was related to decreased ACE activity and NOX activation by EWH and, subsequently, alleviated ROS production and improved NO bioavailability in aorta. In conclusion, EWH could be considered as alternative or complementary treatment tools for Hg-induced cardiovascular damage.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/tratamento farmacológico
Clara de Ovo/química
Mercúrio/toxicidade
NADPH Oxidases/sangue
Peptídeos/farmacologia
Peptidil Dipeptidase A/sangue
[Mh] Termos MeSH secundário: Animais
Aorta/efeitos dos fármacos
Aorta/metabolismo
Pressão Sanguínea/efeitos dos fármacos
Doenças Cardiovasculares/induzido quimicamente
Relação Dose-Resposta a Droga
Endotélio Vascular/efeitos dos fármacos
Masculino
NADPH Oxidases/antagonistas & inibidores
Estresse Oxidativo/efeitos dos fármacos
Fenilefrina/farmacologia
Ratos
Ratos Wistar
Vasoconstritores/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Peptides); 0 (Vasoconstrictor Agents); 1WS297W6MV (Phenylephrine); EC 1.6.3.- (NADPH Oxidases); EC 3.4.15.1 (Peptidyl-Dipeptidase A); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171009
[St] Status:MEDLINE


  5 / 2228 MEDLINE  
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[PMID]:28980893
[Au] Autor:Matsuoka R; Shirouchi B; Umegatani M; Fukuda M; Muto A; Masuda Y; Kunou M; Sato M
[Ad] Endereço:1R&D Division,Kewpie Corporation,Sengawa Kewport,2-5-7 Sengawa-cho,Chofu-shi,Tokyo,182-0002,Japan.
[Ti] Título:Dietary egg-white protein increases body protein mass and reduces body fat mass through an acceleration of hepatic ß-oxidation in rats.
[So] Source:Br J Nutr;118(6):423-430, 2017 Sep.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Egg-white protein (EWP) is known to reduce lymphatic TAG transport in rats. In this study, we investigated the effects of dietary EWP on body fat mass. Male rats, 4 weeks old, were fed diets containing either 20 % EWP or casein for 28 d. Carcass protein levels and gastrocnemius leg muscle weights in the EWP group were significantly higher than those in the casein group. In addition, carcass TAG levels and abdominal fat weights in the EWP group were significantly lower than those in the casein group; adipocyte size in abdominal fat in the EWP group was smaller than that in the casein group. To identify the involvement of dietary fat levels in the rats, one of two fat levels (5 or 10 %) was added to their diet along with the different protein sources (EWP and casein). Abdominal fat weight and serum and hepatic TAG levels were significantly lower in the EWP group than in the casein group. Moreover, significantly higher values of enzymatic activity related to ß-oxidation in the liver were observed in the EWP group compared with the casein group. Finally, abdominal fat weight reduction in the EWP group with the 10 % fat diet was lower than that in the EWP group with the 5 % fat diet. In conclusion, our results indicate that, in addition to the inhibition of dietary TAG absorption reported previously, dietary EWP reduces body fat mass in rats through an increase of body protein mass and the acceleration of ß-oxidation in the liver.
[Mh] Termos MeSH primário: Adiposidade
Proteínas Dietéticas do Ovo/administração & dosagem
Fígado/metabolismo
Músculo Esquelético/fisiologia
[Mh] Termos MeSH secundário: Gordura Abdominal/metabolismo
Adipócitos/metabolismo
Animais
Composição Corporal
Índice de Massa Corporal
Caseínas/administração & dosagem
Dieta
Gorduras na Dieta/administração & dosagem
Clara de Ovo/química
Metabolismo dos Lipídeos
Masculino
Tamanho do Órgão/fisiologia
Ratos
Ratos Sprague-Dawley
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caseins); 0 (Dietary Fats); 0 (Egg Proteins, Dietary); 0 (Triglycerides)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517002306


  6 / 2228 MEDLINE  
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[PMID]:28972997
[Au] Autor:Jahandideh F; Chakrabarti S; Davidge ST; Wu J
[Ad] Endereço:Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
[Ti] Título:Egg white hydrolysate shows insulin mimetic and sensitizing effects in 3T3-F442A pre-adipocytes.
[So] Source:PLoS One;12(10):e0185653, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Insulin resistance and inflammation in adipose tissue is a key mechanism underlying metabolic syndrome, a growing health problem characterized by diabetes, obesity and hypertension. Previous work from our research group has demonstrated the potential of egg white ovotransferrin derived bioactive peptides against hypertension, oxidative stress and inflammation in vitro and in vivo. Egg white hydrolysate (EWH) has also shown anti-hypertensive effects in spontaneously hypertensive rats. Given the interplay among hypertension, inflammation, oxidative stress and metabolic syndrome, the objective of the study was to test the EWH on differentiation, insulin signaling and inflammatory responses in 3T3-F442A pre-adipocytes. Our study suggested that EWH could promote adipocyte differentiation as shown by increased lipid accumulation, increased release of adiponectin and upregulation of peroxisome proliferator associated receptor gamma (PPARγ) and CCAAT/ enhancer binding protein alpha (C/EBP-α). In addition to enhanced insulin effects on the upregulation of protein kinase B/Akt phosphorylation, EWH treatment increased extracellular signal regulated kinase 1/2 (ERK1/2) phosphorylation to a level similar to that of insulin, indicating insulin sensitizing and mimetic properties of the EWH. EWH further attenuated cytokine induced inflammatory marker; cyclooxygenase -2 (COX-2) by 48.78%, possibly through the AP-1 pathway by down regulating c-Jun phosphorylation in adipocytes. Given the critical role of adipose in the pathogenesis of insulin resistance and metabolic syndrome, EWH may have potential applications in the prevention and management of metabolic syndrome and its complications.
[Mh] Termos MeSH primário: Adipócitos/metabolismo
Clara de Ovo
Insulina/metabolismo
Mimetismo Molecular
[Mh] Termos MeSH secundário: Células 3T3
Adipócitos/citologia
Adiponectina/metabolismo
Animais
Western Blotting
Diferenciação Celular
Relação Dose-Resposta a Droga
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Camundongos
PPAR gama/metabolismo
Fosforilação
Receptor de Insulina/metabolismo
Transdução de Sinais
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adiponectin); 0 (Insulin); 0 (PPAR gamma); EC 2.7.10.1 (Receptor, Insulin); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185653


  7 / 2228 MEDLINE  
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[PMID]:28797071
[Au] Autor:Xu L; Zhao Y; Xu M; Yao Y; Nie X; Du H; Tu YG
[Ad] Endereço:Jiangxi Key Laboratory of Natural Products and Functional Food, Jiangxi Agricultural University, Nanchang, China.
[Ti] Título:Effects of salting treatment on the physicochemical properties, textural properties, and microstructures of duck eggs.
[So] Source:PLoS One;12(8):e0182912, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In order to illuminate the forming process of salted egg, the effects of the brine solution with different salt concentrations on the physicochemical properties, textural properties, and microstructures of duck eggs were evaluated using conventional physicochemical property determination methods. The results showed that the moisture contents of both the raw and cooked egg whites and egg yolks, the springiness of the raw egg yolks and cooked egg whites exhibited a decreasing trend with the increase in the salting time and salt concentration. The salt content, oil exudation and the hardness of the raw egg yolks showed a constantly increasing trend. Viscosity of the raw egg whites showed an overall trend in which it first deceased and then increased and decreased again, which was similar to the trend of the hardness of the cooked egg whites and egg yolks. As the salting proceeded, the pH value of the raw and cooked egg whites declined remarkably and then declined slowly, whereas the pH of the raw and cooked egg yolks did not show any noticeable changes. The effect of salting on the pH value varied significantly with the salt concentration in the brine solution. Scanning electron microscopy (SEM) revealed that salted yolks consist of spherical granules and embedded flattened porosities. It was concluded that the treatment of salt induces solidification of yolk, accompanied with higher oil exudation and the development of a gritty texture. Different salt concentrations show certain differences.
[Mh] Termos MeSH primário: Culinária
Clara de Ovo/química
Gema de Ovo/química
Ovos
Manipulação de Alimentos/métodos
Cloreto de Sódio/farmacologia
[Mh] Termos MeSH secundário: Animais
Patos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
451W47IQ8X (Sodium Chloride)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182912


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[PMID]:28782363
[Au] Autor:Xu Q; Fan H; Yu W; Hong H; Wu J
[Ad] Endereço:College of Animal Sciences and Technology, Huazhong Agricultural University , Wuhan 430070, China.
[Ti] Título:Transport Study of Egg-Derived Antihypertensive Peptides (LKP and IQW) Using Caco-2 and HT29 Coculture Monolayers.
[So] Source:J Agric Food Chem;65(34):7406-7414, 2017 Aug 30.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to investigate the mechanisms of the transport of antihypertensive tripeptides LKP (Leu-Lys-Pro) and IQW (Ile-Gln-Trp) derived from egg white using a coculture system of Caco-2 and HT29 cell monolayers. The results revealed that LKP and IQW have no cytotoxicity to the cell viability after 2 h incubation, could be transported intact across coculture monolayers (apparent permeability coefficient: (18.11 ± 1.57) × 10 and (13.21 ± 1.12) × 10 cm/s, respectively), and were resistant to peptidase secreted by enterocytes. In addition, the transports were significantly inhibited by dipeptide Gly-Pro (P < 0.05), a competitive substance of peptide transporter 1 (PepT1). The transports from apical to basolateral side were significantly higher than that of the reverse direction (P < 0.05). These results suggest that PepT1 is involved in LKP and IQW transports. The transports were also significantly decreased by theaflavin-3'-O-gallate (P < 0.05), an enhancer of tight junction (TJ) and increased by cytochalasin D (P < 0.05), a disruptor of TJ but not influenced by wortamanin, a transcytosis inhibitor, suggesting that passive paracellular route via TJs is also involved in LKP and IQW transports but not transcytosis. In addition, siRNA was also used to knockdown the expression of PepT1 and significantly inhibited the transport (P < 0.05), confirming that PepT1 is involved in transport process. Therefore, both passive paracellular route via TJ and active route via PepT1 coexist in the transport of antihypertensive LKP and IQW across Caco-2/HT29 coculture monolayers.
[Mh] Termos MeSH primário: Anti-Hipertensivos/metabolismo
Clara de Ovo/química
Oligopeptídeos/metabolismo
[Mh] Termos MeSH secundário: Animais
Anti-Hipertensivos/química
Anti-Hipertensivos/farmacologia
Transporte Biológico
Células CACO-2
Sobrevivência Celular/efeitos dos fármacos
Galinhas
Células HT29
Seres Humanos
Oligopeptídeos/química
Oligopeptídeos/farmacologia
Junções Íntimas/efeitos dos fármacos
Junções Íntimas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antihypertensive Agents); 0 (Oligopeptides); 0 (leucyl-lysyl-proline)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b02176


  9 / 2228 MEDLINE  
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[PMID]:28639707
[Au] Autor:Westby MJ; Dumville JC; Soares MO; Stubbs N; Norman G
[Ad] Endereço:Division of Nursing, Midwifery & Social Work, School of Health Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester Academic Health Science Centre, Jean McFarlane Building, Oxford Road, Manchester, UK, M13 9PL.
[Ti] Título:Dressings and topical agents for treating pressure ulcers.
[So] Source:Cochrane Database Syst Rev;6:CD011947, 2017 06 22.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are localised areas of injury to the skin or the underlying tissue, or both. Dressings are widely used to treat pressure ulcers and promote healing, and there are many options to choose from including alginate, hydrocolloid and protease-modulating dressings. Topical agents have also been used as alternatives to dressings in order to promote healing.A clear and current overview of all the evidence is required to facilitate decision-making regarding the use of dressings or topical agents for the treatment of pressure ulcers. Such a review would ideally help people with pressure ulcers and health professionals assess the best treatment options. This review is a network meta-analysis (NMA) which assesses the probability of complete ulcer healing associated with alternative dressings and topical agents. OBJECTIVES: To assess the effects of dressings and topical agents for healing pressure ulcers in any care setting. We aimed to examine this evidence base as a whole, determining probabilities that each treatment is the best, with full assessment of uncertainty and evidence quality. SEARCH METHODS: In July 2016 we searched the Cochrane Wounds Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL); Ovid MEDLINE; Ovid MEDLINE (In-Process & Other Non-Indexed Citations); Ovid Embase and EBSCO CINAHL Plus. We also searched clinical trials registries for ongoing and unpublished studies, and scanned reference lists of relevant included studies as well as reviews, meta-analyses, guidelines and health technology reports to identify additional studies. There were no restrictions with respect to language, date of publication or study setting. SELECTION CRITERIA: Published or unpublished randomised controlled trials (RCTs) comparing the effects of at least one of the following interventions with any other intervention in the treatment of pressure ulcers (Stage 2 or above): any dressing, or any topical agent applied directly to an open pressure ulcer and left in situ. We excluded from this review dressings attached to external devices such as negative pressure wound therapies, skin grafts, growth factor treatments, platelet gels and larval therapy. DATA COLLECTION AND ANALYSIS: Two review authors independently performed study selection, risk of bias assessment and data extraction. We conducted network meta-analysis using frequentist mega-regression methods for the efficacy outcome, probability of complete healing. We modelled the relative effectiveness of any two treatments as a function of each treatment relative to the reference treatment (saline gauze). We assumed that treatment effects were similar within dressings classes (e.g. hydrocolloid, foam). We present estimates of effect with their 95% confidence intervals for individual treatments compared with every other, and we report ranking probabilities for each intervention (probability of being the best, second best, etc treatment). We assessed the certainty (quality) of the body of evidence using GRADE for each network comparison and for the network as whole. MAIN RESULTS: We included 51 studies (2947 participants) in this review and carried out NMA in a network of linked interventions for the sole outcome of probability of complete healing. The network included 21 different interventions (13 dressings, 6 topical agents and 2 supplementary linking interventions) and was informed by 39 studies in 2127 participants, of whom 783 had completely healed wounds.We judged the network to be sparse: overall, there were relatively few participants, with few events, both for the number of interventions and the number of mixed treatment contrasts; most studies were small or very small. The consequence of this sparseness is high imprecision in the evidence, and this, coupled with the (mainly) high risk of bias in the studies informing the network, means that we judged the vast majority of the evidence to be of low or very low certainty. We have no confidence in the findings regarding the rank order of interventions in this review (very low-certainty evidence), but we report here a summary of results for some comparisons of interventions compared with saline gauze. We present here only the findings from evidence which we did not consider to be very low certainty, but these reported results should still be interpreted in the context of the very low certainty of the network as a whole.It is not clear whether regimens involving protease-modulating dressings increase the probability of pressure ulcer healing compared with saline gauze (risk ratio (RR) 1.65, 95% confidence interval (CI) 0.92 to 2.94) (moderate-certainty evidence: low risk of bias, downgraded for imprecision). This risk ratio of 1.65 corresponds to an absolute difference of 102 more people healed with protease modulating dressings per 1000 people treated than with saline gauze alone (95% CI 13 fewer to 302 more). It is unclear whether the following interventions increase the probability of healing compared with saline gauze (low-certainty evidence): collagenase ointment (RR 2.12, 95% CI 1.06 to 4.22); foam dressings (RR 1.52, 95% CI 1.03 to 2.26); basic wound contact dressings (RR 1.30, 95% CI 0.65 to 2.58) and polyvinylpyrrolidone plus zinc oxide (RR 1.31, 95% CI 0.37 to 4.62); the latter two interventions both had confidence intervals consistent with both a clinically important benefit and a clinically important harm, and the former two interventions each had high risk of bias as well as imprecision. AUTHORS' CONCLUSIONS: A network meta-analysis (NMA) of data from 39 studies (evaluating 21 dressings and topical agents for pressure ulcers) is sparse and the evidence is of low or very low certainty (due mainly to risk of bias and imprecision). Consequently we are unable to determine which dressings or topical agents are the most likely to heal pressure ulcers, and it is generally unclear whether the treatments examined are more effective than saline gauze.More research is needed to determine whether particular dressings or topical agents improve the probability of healing of pressure ulcers. The NMA is uninformative regarding which interventions might best be included in a large trial, and it may be that research is directed towards prevention, leaving clinicians to decide which treatment to use on the basis of wound symptoms, clinical experience, patient preference and cost.
[Mh] Termos MeSH primário: Bandagens
Fármacos Dermatológicos/uso terapêutico
Lesão por Pressão/terapia
Cicatrização
[Mh] Termos MeSH secundário: Alginatos/uso terapêutico
Curativos Hidrocoloides
Colagenases/uso terapêutico
Clara de Ovo
Géis/uso terapêutico
Ácido Glucurônico/uso terapêutico
Ácidos Hexurônicos/uso terapêutico
Seres Humanos
Metanálise em Rede
Pomadas/uso terapêutico
Excipientes Farmacêuticos/uso terapêutico
Fenitoína/uso terapêutico
Povidona/uso terapêutico
Ensaios Clínicos Controlados Aleatórios como Assunto
Óxido de Zinco/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Alginates); 0 (Dermatologic Agents); 0 (Gels); 0 (Hexuronic Acids); 0 (Ointments); 0 (Pharmaceutic Aids); 6158TKW0C5 (Phenytoin); 8A5D83Q4RW (Glucuronic Acid); 8C3Z4148WZ (alginic acid); EC 3.4.24.- (Collagenases); FZ989GH94E (Povidone); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD011947.pub2


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[PMID]:28485214
[Au] Autor:Kobayashi H; Sasahara R; Yoda S; Kotake-Nara E
[Ad] Endereço:a Institute of Technology R&D Div. , Kewpie Corporation, Chofu , Japan.
[Ti] Título:Egg white hydrolysate inhibits oxidation in mayonnaise and a model system.
[So] Source:Biosci Biotechnol Biochem;81(6):1206-1215, 2017 Jun.
[Is] ISSN:1347-6947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The flavor deterioration of mayonnaise is induced by iron, which is released from egg yolk phosvitin under acidic conditions and promotes lipid oxidation. To prevent oxidative deterioration, natural components, rather than synthetic chemicals such as ethylenediaminetetraacetic acid have been required by consumers. In the present study, we evaluated the inhibitory effects of three egg white components with the same amino acid composition, namely egg white protein, hydrolysate, and the amino acid mixture, on lipid oxidation in mayonnaise and an acidic egg yolk solution as a model system. We found that the hydrolysate had the strongest inhibitory effect on lipid oxidation among the three components. The mechanism underlying the antioxidant effect was associated with Fe -chelating activity. Thus, egg white hydrolysate may have the potential as natural inhibitors of lipid oxidation in mayonnaise.
[Mh] Termos MeSH primário: Ácido Acético/química
Antioxidantes/química
Clara de Ovo/química
Gema de Ovo/química
Quelantes de Ferro/química
Óleos Vegetais/química
Hidrolisados de Proteína/química
[Mh] Termos MeSH secundário: Aminoácidos/química
Compostos de Bifenilo/antagonistas & inibidores
Proteínas do Ovo
Emulsões
Análise de Alimentos
Conservação de Alimentos/métodos
Seres Humanos
Oxirredução
Picratos/antagonistas & inibidores
Soluções
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Egg Proteins); 0 (Emulsions); 0 (Iron Chelating Agents); 0 (Picrates); 0 (Plant Oils); 0 (Protein Hydrolysates); 0 (Solutions); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); Q40Q9N063P (Acetic Acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.1080/09168451.2017.1290519



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