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[PMID]:29209154
[Au] Autor:Tinsley GM; Hamm MA; Hurtado AK; Cross AG; Pineda JG; Martin AY; Uribe VA; Palmer TB
[Ad] Endereço:Energy Balance & Body Composition Laboratory, Musculoskeletal Assessment Laboratory, Department of Kinesiology & Sport Management, Texas Tech University, Box 43011, Lubbock, TX 79409 USA.
[Ti] Título:Effects of two pre-workout supplements on concentric and eccentric force production during lower body resistance exercise in males and females: a counterbalanced, double-blind, placebo-controlled trial.
[So] Source:J Int Soc Sports Nutr;14:46, 2017.
[Is] ISSN:1550-2783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Pre-workout supplements purportedly enhance feelings of energy, reduce fatigue and improve exercise performance. The purpose of this study was to examine the performance effects of caffeinated and non-caffeinated multi-ingredient pre-workout supplements. Methods: In a counterbalanced, double-blind, placebo-controlled design, eccentric and concentric force production during lower body resistance exercise on a mechanized squat device were assessed after supplement ingestion. Repetitions-in-reserve/RPE and subjective feelings of energy, focus and fatigue were also examined. Twenty-one resistance-trained adults (12 F, 9 M) completed three conditions in random order: caffeinated supplement, non-caffeinated supplement and placebo. Subjects were not informed of the presence of a placebo condition. Thirty minutes after supplement ingestion, a 3-repetition maximum test and 5 sets of 6 repetitions were completed using the squat device. Each repetition involved 4-s eccentric and concentric phases, and the force signal throughout each repetition was sampled from a load cell contained within the squat device. The scaled and filtered force signals were analyzed using customized software. Repeated measures analysis of variance and appropriate follow-up analyses were utilized to compare dependent variables, and relevant effect sizes (d) were calculated. Results: Supplement or placebo ingestion led to similar subjective responses ( > 0.05). Energy (+8 to 44%; d = 0.3 to 0.8) and focus (+8 to 25%; d = 0.3 to 0.5) were acutely increased by supplement or placebo ingestion and decreased as the exercise session progressed. Fatigue was acutely decreased by supplement or placebo ingestion (-7 to 38%; d = -0.1 to -0.6) and increased as the exercise session progressed. Eccentric and concentric forces were unimproved by supplementation during the exercise sets for both sexes. In the non-caffeinated supplement condition only, maximal eccentric force production was lower during sets 3 to 5, as compared to set 1 ( < 0.05). Effect size data indicated that both the caffeinated and non-caffeinated supplements may contribute to small increases in concentric force production in males (+5 to 20%, d = 0.2 to 0.4 relative to placebo), but not females. Conclusions: As compared to placebo, caffeinated and non-caffeinated multi-ingredient pre-workout supplements failed to improve concentric and eccentric force production. In males, effect size data indicate a possible small benefit of supplementation on concentric force production, although this was not statistically significant. When resistance-trained subjects were unaware of the presence of a placebo, resistance exercise performance was similar regardless of whether a placebo or multi-ingredient supplement was ingested.
[Mh] Termos MeSH primário: Cafeína/farmacologia
Suplementos Nutricionais
Músculo Esquelético/efeitos dos fármacos
Músculo Esquelético/fisiologia
Treinamento de Resistência
[Mh] Termos MeSH secundário: Análise de Variância
Método Duplo-Cego
Fadiga
Feminino
Alimentos Formulados
Seres Humanos
Masculino
Resistência Física/efeitos dos fármacos
Resistência Física/fisiologia
Fatores Sexuais
Fenômenos Fisiológicos da Nutrição Esportiva
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
3G6A5W338E (Caffeine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1186/s12970-017-0203-x


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[PMID]:28747328
[Au] Autor:Christensen P; Henriksen M; Bartels EM; Leeds AR; Meinert Larsen T; Gudbergsen H; Riecke BF; Astrup A; Heitmann BL; Boesen M; Christensen R; Bliddal H
[Ad] Endereço:The Parker Institute and Departments of.
[Ti] Título:Long-term weight-loss maintenance in obese patients with knee osteoarthritis: a randomized trial.
[So] Source:Am J Clin Nutr;106(3):755-763, 2017 Sep.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A formula low-energy diet (LED) reduces weight effectively in obese patients with knee osteoarthritis, but the role of LED in long-term weight-loss maintenance is unclear. We aimed to determine the effect of intermittent LED compared with daily meal replacements on weight-loss maintenance and number of knee replacements over 3 y. The design was a randomized trial with participants aged >50 y who had knee osteoarthritis and a body mass index [BMI (in kg/m )] ≥30. Participants were recruited from the osteoarthritis outpatient clinic at Copenhagen University Hospital in Frederiksberg, Denmark; they had previously completed a 68-wk lifestyle intervention trial and achieved an average weight loss of 10.5 kg (10% of initial body weight). Participants were randomly assigned to either the intermittent treatment (IN) group with LED for 5 wk every 4 mo for 3 y or to daily meal replacements of 1-2 meals for 3 y [regular (RE) group]. Attention by dietitians and the amount of formula products were similar. Primary outcomes were changes in body weight and proportion of participants receiving knee replacements. Outcomes were analyzed on the intention-to-treat-population with the use of baseline-carried-forward imputation for missing data. A total of 153 participants (means ± SDs: BMI: 33.3 ± 4.6; age: 63.8 ± 6.3 y; 83% women) were recruited between June and December 2009 and randomly assigned to the IN ( = 76) or RE ( = 77) group. A total of 53 and 56 participants, respectively, completed the trial. Weight increased by 0.68 and 1.75 kg in the IN and RE groups, respectively (mean difference: -1.06 kg; 95% CI: -2.75, 0.63 kg; = 0.22). Alloplasty rates were low and did not differ (IN group: 8 of 76 participants; RE group: 12 of 77 participants; = 0.35). After a mean 10% weight-loss and 1-y maintenance, additional use of daily meal replacements or intermittent LED resulted in weight-loss maintenance for 3 y. These results challenge the commonly held assumption that weight regain in the long term is inevitable. This trial was registered at clinicaltrials.gov as NCT00938808.
[Mh] Termos MeSH primário: Índice de Massa Corporal
Manutenção do Peso Corporal
Restrição Calórica
Dieta Redutora/métodos
Ingestão de Energia
Obesidade/dietoterapia
Osteoartrite do Joelho/complicações
[Mh] Termos MeSH secundário: Idoso
Artroplastia do Joelho
Feminino
Alimentos Formulados
Seres Humanos
Estilo de Vida
Masculino
Refeições
Meia-Idade
Osteoartrite do Joelho/cirurgia
Ganho de Peso
Perda de Peso
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180124
[Lr] Data última revisão:
180124
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170728
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.117.158543


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[PMID]:28468699
[Au] Autor:Hostetler GL
[Ad] Endereço:Perrigo Nutritionals, Analytical Research and Development, 147 Industrial Park Rd, Georgia, VT 05468.
[Ti] Título:Determination of Lutein and ß-Carotene in Infant Formula and Adult Nutritionals by Ultra-High-Performance Liquid Chromatography: Single-Laboratory Validation, First Action 2016.13.
[So] Source:J AOAC Int;100(3):768-781, 2017 May 01.
[Is] ISSN:1060-3271
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An ultra-HPLC method for the determination of lutein and ß-carotene in infant formula and adult nutritionals was validated using both unfortified and fortified samples provided by the AOAC Stakeholder Panel on Infant Formula and Adult Nutritionals (SPIFAN). All experiments showed separation of all-trans-lutein and ß-carotene from their major cis isomers, apocarotenal, α-carotene, lycopene, and zeaxanthin. Samples spiked with all-trans-lutein and ß-carotene showed no isomerization during sample preparation. Linearity of the calibration solutions correlated to approximately 0.8-45 µg/100 g (reconstituted basis) for samples prepared for the lowest sample concentrations. With dilutions specified in the method, the range can be extended to approximately 2250 µg/100 g. The LOD for both lutein and ß-carotene was 0.08 µg/100 g, and the LOQ for both was 0.27 µg/100 g. For all measurements in the range of 1-100 µg/100 g, repeatability RSD was ≤5.8% for lutein and ≤5.1% for ß-carotene. For measurements >100 µg/100 g, repeatability RSD was ≤1.1% for lutein and ≤1.7% for ß-carotene. Accuracy was determined by recovery from spiked samples and ranged from 92.3 to 105.5% for lutein and from 100.1 to 107.5% for ß-carotene. The data provided show that the method meets the criteria specified in the Standard Method Performance Requirements for carotenoids (SMPR 2014.014).
[Mh] Termos MeSH primário: Alimentos Formulados/análise
Fórmulas Infantis/análise
Luteína/análise
beta Caroteno/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
01YAE03M7J (beta Carotene); X72A60C9MT (Lutein)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.5740/jaoacint.16-0386


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[PMID]:28860135
[Au] Autor:Young BE
[Ad] Endereço:Assistant Professor of Pediatric Nutrition, School of Medicine, University of Colorado bridget.young@ucdenver.edu.
[Ti] Título:Formula Feeding Exposure Not Homogenous.
[So] Source:Pediatrics;140(3), 2017 09.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Aleitamento Materno
Fórmulas Infantis
[Mh] Termos MeSH secundário: Alimentos Formulados
Seres Humanos
Lactente
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE


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[PMID]:28659406
[Au] Autor:Piccolo BD; Mercer KE; Bhattacharyya S; Bowlin AK; Saraf MK; Pack L; Chintapalli SV; Shankar K; Adams SH; Badger TM; Yeruva L
[Ad] Endereço:Arkansas Children's Nutrition Center, Little Rock, AR; bdpiccolo@uams.edu VLYeruva@uams.edu.
[Ti] Título:Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs.
[So] Source:J Nutr;147(8):1499-1509, 2017 Aug.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Breastfeeding is known to be protective against gastrointestinal disorders and may modify gut development. Although the gut microbiome has been implicated, little is known about how early diet affects the small intestine microbiome. We hypothesized that disparate early diets would promote unique microbial profiles in the small intestines of neonatal pigs. Male and female 2-d-old White Dutch Landrace pigs were either sow fed or provided dairy (Similac Advance powder; Ross Products Abbott Laboratories) or soy (Enfamil Prosobee Lipil powder; Mead Johnson Nutritionals) infant formulas until day 21. Bacterial ecology was assessed in the contents of the small intestine through the use of 16S ribosomal RNA sequencing. α-Diversity, ß-diversity, and differential abundances of operational taxonomic units were assessed by ANOVA, permutational ANOVA, and negative binomial regression, respectively. Ileum tissue metabolomics were measured by LC-mass spectrometry and assessed by weighted correlation network analysis. Greater α-diversity was observed in the duodena of sow-fed compared with formula-fed neonatal pigs ( < 0.05). No differences were observed in the ilea. Firmicutes represented the most abundant phylum across all diets in duodena (78.8%, 80.1%, and 53.4% relative abundance in sow, dairy, and soy groups, respectively), followed by Proteobacteria in sow (12.2%) and dairy (12.4%) groups and Cyanobacteria in soy-fed (36.2%) pigs. In contrast to those in the duodenum, Proteobacteria was the dominant phylum in the ileum, with >60% relative abundance in all of the groups. In the duodenum, 77 genera were altered by diet, followed by 48 in the jejunum and 19 in the ileum. Metabolomics analyses revealed associations between ileum tissue metabolites (e.g., acylcarnitines, 3-aminoisobutyric acid) and diet-responsive microbial genera. These results indicate that the neonatal diet has regional effects on the small intestine microbiome in pigs, with the most pronounced effects occurring in the duodena. Regional effects may be important factors when considering gut tissue metabolism and development in the postnatal period.
[Mh] Termos MeSH primário: Bactérias/efeitos dos fármacos
Dieta
Microbioma Gastrointestinal/efeitos dos fármacos
Intestino Delgado/efeitos dos fármacos
Metaboloma/efeitos dos fármacos
Proteínas do Leite/farmacologia
Proteínas de Soja/farmacologia
[Mh] Termos MeSH secundário: Ácidos Aminoisobutíricos/metabolismo
Animais
Animais Recém-Nascidos
Bactérias/genética
Carnitina/análogos & derivados
Carnitina/metabolismo
Duodeno/efeitos dos fármacos
Duodeno/microbiologia
Comportamento Alimentar
Feminino
Alimentos Formulados
Seres Humanos
Íleo/efeitos dos fármacos
Íleo/metabolismo
Intestino Delgado/metabolismo
Intestino Delgado/microbiologia
Masculino
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aminoisobutyric Acids); 0 (Milk Proteins); 0 (Soybean Proteins); 0 (acylcarnitine); S7UI8SM58A (Carnitine); T68ALE2O9F (3-aminoisobutyric acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.252767


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[PMID]:28619005
[Au] Autor:Rai VRH; Phang LF; Sia SF; Amir A; Veerakumaran JS; Kassim MKA; Othman R; Tah PC; Loh PS; Jailani MIO; Ong G
[Ad] Endereço:School of Medicine, Taylor's University, Lakeside Campus, 47500, Subang Jaya, Malaysia.
[Ti] Título:Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial.
[So] Source:BMC Anesthesiol;17(1):81, 2017 Jun 15.
[Is] ISSN:1471-2253
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Head injury is one of the top three diagnosis leading to intensive care unit (ICU) admission in Malaysia. There has been growing interest in using immunonutrition as a mode of modulating the inflammatory response to injury or infection with the aim of improving clinical outcome. The aim of the present study was to evaluate the effect of an immunonutrition on biomarkers (IL-6, glutathione, CRP, total protein and albumin) in traumatic brain injury patients. METHODS: Thirty six patients with head injury admitted to neurosurgical ICU in University Malaya Medical Centre were recruited for this study, over a 6-month period from July 2014 to January 2015. Patients were randomized to receive either an immunonutrition (Group A) or a standard (Group B) enteral feed. Levels of biomarkers were measured at day 1, 5 and 7 of enteral feeding. RESULTS: Patients in Group A showed significant reduction of IL-6 at day 5 (p < 0.001) with concurrent rise in glutathione levels (p = 0.049). Patients in Group A also demonstrated a significant increase of total protein level at the end of the study (day 7). CONCLUSION: These findings indicate the potential of immunonutrition reducing cytokines and increasing antioxidant indices in patients with TBI. However, further studies incorporating patient outcomes are needed to determine its overall clinical benefits. TRIAL REGISTRATION: National Medical Research Register (NMRR) ID: 14-1430-23,171. ClinicalTrials.gov identifier: NCT03166449 .
[Mh] Termos MeSH primário: Lesões Encefálicas Traumáticas/dietoterapia
Nutrição Enteral
Alimentos Formulados
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Aminoácidos
Biomarcadores/sangue
Proteínas Sanguíneas/análise
Proteína C-Reativa/análise
Feminino
Glutationa/sangue
Seres Humanos
Interleucina-6/sangue
Masculino
Meia-Idade
Estudos Prospectivos
Albumina Sérica/análise
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Amino Acids); 0 (Biomarkers); 0 (Blood Proteins); 0 (Interleukin-6); 0 (Serum Albumin); 9007-41-4 (C-Reactive Protein); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE
[do] DOI:10.1186/s12871-017-0369-4


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[PMID]:28615258
[Au] Autor:Stobaugh HC; Bollinger LB; Adams SE; Crocker AH; Grise JB; Kennedy JA; Thakwalakwa C; Maleta KM; Dietzen DJ; Manary MJ; Trehan I
[Ad] Endereço:Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA.
[Ti] Título:Effect of a package of health and nutrition services on sustained recovery in children after moderate acute malnutrition and factors related to sustaining recovery: a cluster-randomized trial.
[So] Source:Am J Clin Nutr;106(2):657-666, 2017 Aug.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Children who recover from moderate acute malnutrition (MAM) have high rates of relapse in the year after nutritional recovery. Interventions to decrease these adverse outcomes are needed to maximize the overall effectiveness of supplemental feeding programs (SFPs). We evaluated the effectiveness of a package of health and nutrition interventions on improving the proportion of children who sustained recovery for 1 y after MAM treatment. We further explored factors related to sustained recovery. We conducted a cluster-randomized clinical effectiveness trial involving rural Malawian children aged 6-62 mo who were enrolled on discharge from an SFP for MAM. We enrolled 718 children at 10 control sites and 769 children at 11 intervention sites. In addition to routine health and nutrition counseling, the intervention group received a package of health and nutrition interventions that consisted of a lipid nutrient supplement, deworming medication, zinc supplementation, a bed net, and malaria chemoprophylaxis. A survival analysis was used to determine the effectiveness of the intervention as well as to identify factors associated with sustained recovery. Of 1383 children who returned for the full 12-mo follow-up period, 407 children (56%) and 347 children (53%) sustained recovery in the intervention and control groups, respectively. There was no significant difference in relapse-free survival curves between the treatment and control groups ( = 0.380; log-rank test). The risk factors for relapse or death after initial recovery were a smaller midupper arm circumference on SFP admission ( = 0.01) and discharge ( < 0.001), a lower weight-for-height score on discharge ( < 0.01), and the receipt of ready-to-use supplementary food as opposed to ready-to-use therapeutic food during treatment ( < 0.05). The provision of a package of health and nutrition services in addition to traditional SFP treatment has no significant effect on improving sustained recovery in children after treatment of MAM. This trial was registered at clinicaltrials.gov as NCT02351687.
[Mh] Termos MeSH primário: Transtornos da Nutrição Infantil/terapia
Suplementos Nutricionais
Alimentos Formulados
Alimentos Fortificados
Serviços de Saúde
Desnutrição/terapia
Estado Nutricional
[Mh] Termos MeSH secundário: Criança
Transtornos da Nutrição Infantil/dietoterapia
Fenômenos Fisiológicos da Nutrição Infantil
Pré-Escolar
Feminino
Seguimentos
Seres Humanos
Lactente
Lipídeos/uso terapêutico
Malária/prevenção & controle
Malaui
Masculino
Desnutrição/dietoterapia
Doenças Parasitárias/prevenção & controle
Recidiva
População Rural
Ganho de Peso
Zinco/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Lipids); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.149799


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[PMID]:28601336
[Au] Autor:Lin ZL; Tan SJ; Cheng MH; Zhao CY; Yu WK; He YL; Li J; Li N
[Ad] Endereço:Department of Gastrointestinal Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
[Ti] Título:Lipid-rich enteral nutrition controls intestinal inflammation, improves intestinal motility and mucosal barrier damage in a rat model of intestinal ischemia/reperfusion injury.
[So] Source:J Surg Res;213:75-83, 2017 Jun 01.
[Is] ISSN:1095-8673
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: It has been reported that lipid-rich enteral nutrition (EN) could ameliorate inflammation in various diseases. In this study, we investigated whether lipid-rich EN could control intestinal inflammation, improve intestinal motility and mucosal barrier injury after intestinal ischemia/reperfusion (I/R) injury. METHODS: Male adult rats received saline, conventional EN, or lipid-rich EN via gavage before and after intestinal I/R injury. The superior mesenteric artery was occluded for 60 min. The sham group underwent laparotomy without superior mesenteric artery occlusion and was administrated saline. Intestinal motility was measured 4 h after intestinal I/R injury by fluorescein isothiocyanate-dextran transit assay; the intestinal and systemic inflammation were assessed by analyzing intestinal and serum concentrations of tumor necrosis factor α, interleukin (IL)- 6, and IL-10, separately. The intestinal mucosal barrier injury was assessed by analyzing the serum levels of intestinal fatty acid-binding protein (I-FABP) and intestinal mucosal tight junction (TJ) proteins. RESULTS: The intestinal I/R injury decreased intestinal motility and intestinal mucosal TJs expression significantly when compared with the sham group (P < 0.05). The intestinal and systemic inflammatory parameters and the serum I-FABP were also significantly higher in the I/R groups than those in the sham group (P < 0.05). Both conventional and lipid-rich EN increased the intestinal motility and the intestinal mucosal TJs expression and decreased the intestinal and systemic inflammatory parameter and serum I-FABP levels to different degrees when compared with the I/R group (P < 0.05). However, lipid-rich EN significantly improved the negative alterations in these biochemical parameters when compared with the conventional EN (P < 0.05). CONCLUSIONS: These results suggest that lipid-rich EN might be able to control intestinal inflammation, improve intestinal motility and mucosal barrier injury after intestinal I/R injury. Thus, the administration of lipid-rich EN may be an effective treatment for promoting gastrointestinal function recovery after intestinal I/R injury.
[Mh] Termos MeSH primário: Nutrição Enteral/métodos
Alimentos Formulados
Motilidade Gastrointestinal/fisiologia
Mucosa Intestinal/patologia
Lipídeos/uso terapêutico
Traumatismo por Reperfusão/terapia
[Mh] Termos MeSH secundário: Animais
Biomarcadores/metabolismo
Inflamação/etiologia
Inflamação/metabolismo
Inflamação/patologia
Inflamação/prevenção & controle
Mucosa Intestinal/metabolismo
Mucosa Intestinal/fisiopatologia
Masculino
Permeabilidade
Distribuição Aleatória
Ratos
Ratos Sprague-Dawley
Traumatismo por Reperfusão/metabolismo
Traumatismo por Reperfusão/patologia
Traumatismo por Reperfusão/fisiopatologia
Junções Íntimas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Lipids)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170612
[St] Status:MEDLINE


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[PMID]:28551707
[Au] Autor:Miller TL; Lee D; Giefer M; Wahbeh G; Suskind DL
[Ad] Endereço:Department of Pediatrics, Seattle Children's Hospital and University of Washington, 4800 Sandpoint Way NE, Seattle, WA, 98105, USA. talya.miller@seattlechildrens.org.
[Ti] Título:Nutritional Therapy in Very Early-Onset Inflammatory Bowel Disease: A Case Report.
[So] Source:Dig Dis Sci;62(8):2196-2200, 2017 Aug.
[Is] ISSN:1573-2568
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract caused by a dysregulated immune response to the fecal microbiota. Very early-onset inflammatory bowel disease (VEO-IBD) refers to a subgroup of pediatric patients with IBD diagnosed before 6 years of age. This subgroup is often characterized by increased severity, aggressive progression, strong family history of IBD, and often poor response to conventional treatments. Nutritional therapies have been utilized to treat IBD, but their role in VEO-IBD is unclear. Disease behavior in VEO-IBD is often different from disease in adolescents and adults, as it is often restricted to the colon and refractory to standard medical therapies. Up to 25% of VEO-IBD patients have an identified underlying immunodeficiency, which may impact response to therapy. While specific mutations in interleukin 10 (IL-10), the IL-10 receptor (IL-10R), and mutations in NCF2, XIAP, LRBA, and TTC7 have been identified in VEO-IBD, polymorphisms in these genes are also associated with increased risk of developing IBD in adolescence or adulthood. We describe two cases in which infants presenting with VEO-IBD achieved clinical remission using exclusive enteral nutrition, a formula-based diet which has been shown to induce remission in older children with active Crohn's disease.
[Mh] Termos MeSH primário: Nutrição Enteral/métodos
Alimentos Formulados
Doenças Inflamatórias Intestinais/dietoterapia
Indução de Remissão/métodos
[Mh] Termos MeSH secundário: Idade de Início
Sedimentação Sanguínea
Seres Humanos
Lactente
Doenças Inflamatórias Intestinais/sangue
Masculino
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170529
[St] Status:MEDLINE
[do] DOI:10.1007/s10620-017-4616-9


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Fotocópia
[PMID]:28440522
[Au] Autor:Tang W; Chen Y; Pan M; Chen L; Zhang L; Wang T; Zhang X; Zhang P; Zheng C; Yu B
[Ad] Endereço:Department of Nutrition, Fudan University Pudong Medical Center, Shanghai 201399, China.
[Ti] Título:[Nutrition management in obese patients with type 2 diabetes mellitus after laparoscopic sleeve gastrectomy].
[So] Source:Zhonghua Wei Chang Wai Ke Za Zhi;20(4):411-416, 2017 Apr 25.
[Is] ISSN:1671-0274
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To explore the value of nutrition management in obese patients with type 2 diabetes mellitus(T2DM) after laparoscopic sleeve gastrectomy(LSG). METHODS: Clinical data of 22 obese T2DM patients undergoing LSG from March 2013 to July 2015 in Fudan University Pudong Medical Center were collected. All the patients strictly followed the specialized instruction by nutritionists: diabetic and low calorie diet 3347.2 to 5020.8 kJ (800 to 1200 kcal) per day before the operation; low calorie liquid diet 2510.4 kJ(600 kcal) per day before operation for promoting gastric emptying; fasting diet before postoperative ventilation; clear liquid diet 1673.6 to 2510.4 kJ (400 to 600 kcal) per day after postoperative ventilation (liquid intake >2000 ml); low fat liquid diet 2928.8 to 3765.6 kJ (700 to 900 kcal) per day (protein 60 g per day at least, 2000 ml liquid) 2 weeks after the operation; semi-liquid diet 1 month after operation and gradually normal diet. All the 22 patients were followed up at 1 week, 1, 3, 6 months after operation on time. Changes of body weight, waist circumference, hip circumference, body mass index(BMI), blood glucose indexes induding fasting blood glucose(FBG), 2-hour postparandial blood glucose(PBG), fasting C-peptide, 2-hour postprandial C-peptide, fasting serum inculin(FINS), 2-hour postprandial inculin(INS), HbAlc, blood pressure and blood lipid indexes were observed and analyzed before and 1 week, 1, 3, 6 months after operation. RESULTS: The average age of 22 patients (10 men and 12 women) was 38.6 years (18 to 66 years). The duration of diabetes varied from 1 month to 15 years. Comorbidity included 12 patients of high blood pressure, 14 of fatty liver, 1 of coronary heart disease, 1 of gout, 1 of chronic thyroiditis and 1 of menstrual disorder. LSG was performed successfully in all the patients and no severe complications and transference to laparotomy occurred. As compared to pre-operation, at 6 months after operation, the average body weight decreased from (103.9±20.2) kg to (80.9±12.6) kg (t=6.294, P=0.000), waist circumference from (118.6±13.8) cm to (96.4±8.0) cm (t=6.331, P=0.000), hip circumference from (116.9±12.6) cm to (104.0±7.7) cm (t=3.854, P=0.000), BMI from (36.2±5.9) kg/m to (27.9±3.5) kg/m (t=5.630, P=0.000), showing a decreasing trend over time. There was no underweight patient after 6 months follow-up. As compared to pre-operation, at 6 months after operation, the average FBG reduced from (7.4±1.4) mmol/L to (6.0±0.9) mmol/L (t=3.172, P=0.003), 2 h PBG from (14.1±4.9) mmol/L to (7.5±2.2) mmol/L (t=7.026, P=0.000), FINS from (160.0±71.9) mIU/L to (43.8±20.8) mIU/L (t=7.259, P=0.000), 2-hour postprandial INS from (437.6±261.4) mIU/L to (140.5±104.6) mIU/L (t=5.858, P=0.000), fasting C-peptide from (1.1±0.6) µg/L to (0.7±0.3) µg/L (t=3.560, P=0.000), 2-hour postprandial C-peptide from (2.5±0.9) µg/L to (1.5±0.7) µg/L (t=3.865, P=0.000), HbAlc from (8.0±1.6)% to (5.9±0.6)% (t=5.953, P=0.000), showing a decreasing trend over time except FBG, 2h postprandial C-peptide and HbAlc(all P<0.05). FBG and 2-hour PBG of 16 patients returned to normal 3 months after the operation. Blood pressure and trigly ceride decreased obviously 6 months after operation compared to pre-operation with significant difference(P<0.05). At 6 months after operation, blood pressure of 8 comorbidity patients with high blood pressure became normal (8/12, 66.7%) and of 4 patients improved(4/12, 33.3%); B ultrasound examination revealed normal in 11 comorbidity patients with fatty liver(11/14,78.6%) and improvement in 3 patients (3/14,15.4%). Blood uric acid of the gout patient and the menstruation of the menstrual disorder patient returned to normal 3 months and 1 month after the operation respectively. CONCLUSION: As for obese patients with T2DM undergoing LSG, reasonable nutrition management is helpful to decrease body weight, and to obtain an ideal improvement of blood glucose and blood lipid levels.
[Mh] Termos MeSH primário: Cirurgia Bariátrica
Glicemia/fisiologia
Diabetes Mellitus Tipo 2/terapia
Dietoterapia/métodos
Gastrectomia
Lipídeos/sangue
Lipídeos/fisiologia
Obesidade/terapia
Resultado do Tratamento
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Pesos e Medidas Corporais
Peptídeo C/sangue
Peptídeo C/fisiologia
Restrição Calórica
Terapia Combinada
Comorbidade
Doença das Coronárias/complicações
Diabetes Mellitus Tipo 2/complicações
Dieta para Diabéticos
Endoscopia
Fígado Gorduroso/complicações
Fígado Gorduroso/cirurgia
Feminino
Alimentos Formulados
Hemoglobina A Glicada/fisiologia
Gota/complicações
Gota/cirurgia
Doença de Hashimoto/complicações
Seres Humanos
Hipertensão/complicações
Hipertensão/cirurgia
Insulina/sangue
Insulina/fisiologia
Masculino
Distúrbios Menstruais/complicações
Distúrbios Menstruais/cirurgia
Meia-Idade
Obesidade/complicações
Assistência Perioperatória/métodos
Tireoidite/complicações
Triglicerídeos/sangue
Triglicerídeos/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (C-Peptide); 0 (Glycated Hemoglobin A); 0 (Insulin); 0 (Lipids); 0 (Triglycerides); 0 (hemoglobin A1c protein, human)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE



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