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[PMID]:29494570
[Au] Autor:Heaton D; Huang S; Shiau R; Casillas S; Straily A; Kong LK; Ng V; Petru V
[Ti] Título:Trichinellosis Outbreak Linked to Consumption of Privately Raised Raw Boar Meat - California, 2017.
[So] Source:MMWR Morb Mortal Wkly Rep;67(8):247-249, 2018 Mar 02.
[Is] ISSN:1545-861X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:On January 15, 2017, a hospital physician notified the Alameda County Public Health Department (ACPHD) in California of a patient with a suspected diagnosis of trichinellosis, a roundworm disease transmitted by the consumption of raw or undercooked meat containing Trichinella spp. larvae (1). A family member of the initial patient reported that at least three other friends and family members had been evaluated at area hospitals for fever, myalgia, abdominal pain, diarrhea, and vomiting. The patients had attended a celebration on December 28, 2016, at which several pork dishes were served, including larb, a traditional Laotian raw pork dish, leading the hospital physician to suspect a diagnosis of trichinellosis. Although the event hosts did not know the exact number of attendees, ACPHD identified 29 persons who attended the event and seven persons who did not attend the event, but consumed pork taken home from the event by attendees. The event hosts reported that the meat had come from a domesticated wild boar raised and slaughtered on their private family farm in northern California. ACPHD conducted a case investigation that included identification of additional cases, testing of leftover raw meat, and a retrospective cohort study to identify risk factors for infection.
[Mh] Termos MeSH primário: Surtos de Doenças
Carne/parasitologia
Alimentos Crus/efeitos adversos
Alimentos Crus/parasitologia
Triquinelose/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Animais
California/epidemiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Prática de Saúde Pública
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180302
[St] Status:MEDLINE
[do] DOI:10.15585/mmwr.mm6708a3


  2 / 28518 MEDLINE  
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[PMID]:29254918
[Au] Autor:Tong B; Zhang L; Li GP
[Ad] Endereço:State Key of Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Huhhot 010071, China.
[Ti] Título:Progress in the molecular and genetic modification breeding of beef cattle in China.
[So] Source:Yi Chuan;39(11):984-1015, 2017 Nov 20.
[Is] ISSN:0253-9772
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:The studies of beef cattle breeding in China have been greatly improved with the rapid development of the international beef cattle industrialization. The beef cattle breeding technologies have rapidly transformed from traditional breeding to molecular marker-assisted breeding, genomic selection and genetic modification breeding. Hundreds of candidate genes and molecular markers associated with growth, meat quality, reproduction performance and diseases resistance have been identified, and some of them have already been used in cattle breeding. Genes and molecular markers associated with growth and development are focused on the growth hormone, muscle regulatory factors, myostatin and insulin-like growth factors. Meat quality is mediated by fatty acid transport and deposition related signals, calpains and calpain system, muscle regulatory factors and muscle growth regulation pathways. Reproduction performance is regulated by GnRH-FSH-LH, growth differentiation factor 9, prolactin receptor and forkhead box protein O1. Disease resistance is modulated by the major histocompatibility complex gene family, toll-like receptors, mannose-binding lectin and interferon gene signals. In this review, we summarize the most recent progress in beef cattle breeding in marker-assisted selection, genome-wide selection and genetic modification breeding, aiming to provide a reference for further genetic breeding research of beef cattle in China.
[Mh] Termos MeSH primário: Cruzamento
Bovinos/genética
Carne
[Mh] Termos MeSH secundário: Animais
Metilação de DNA
Proteína Forkhead Box O1/genética
Lectina de Ligação a Manose/genética
Receptores do FSH/genética
Seleção Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Forkhead Box Protein O1); 0 (Mannose-Binding Lectin); 0 (Receptors, FSH)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.16288/j.yczz.17-181


  3 / 28518 MEDLINE  
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[PMID]:29413575
[Au] Autor:Takahashi R; Nakaya M; Kotaniguchi M; Shojo A; Kitamura S
[Ad] Endereço:Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai 599-8531, Japan; YMC Co., Ltd., 284 Daigo-cho, Karasuma Nishiiru Gojo-dori, Shimogyo-ku, Kyoto 600-8106, Japan.
[Ti] Título:Analysis of phosphatidylethanolamine, phosphatidylcholine, and plasmalogen molecular species in food lipids using an improved 2D high-performance liquid chromatography system.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1077-1078:35-43, 2018 Mar 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Phospholipids are an important class of lipids in cell membranes and food. Several high-performance liquid chromatography (HPLC) methods have been developed to analyze phospholipids at the molecular species level. We developed a two-dimensional HPLC system with a charged aerosol detector and mass spectrometry (MS) to analyze phosphatidylethanolamine (PE), phosphatidylcholine (PC), and their plasmalogens (pls) extracted from food materials. Accordingly, the phospholipid molecular species can be analyzed in a single step despite using smaller samples. We confirmed that chromatogram peaks from soybean lecithin are mostly baseline separated, assigned, and quantified (24 molecular species for PE and 27 for PC). In addition, it was confirmed that chromatograms of lipids extracted from chicken breast meat include plasmalogen peaks. The PE fraction in lipids extracted from chicken breast meat contained 17 types of ethanolamine plasmalogens, corresponding to approximately 57% of the total by weight. The PC fraction contained only four choline plasmalogens, corresponding to approximately 11% of the total weight. The composition of the pls-PC molecular species differed from that of pls-PEs. The polyunsaturated fatty acids connected at the sn-2 positions of the pls-PEs consisted of 20.5% 20:4 fatty acid and were independent of the carbon chain at the sn-1 position. However, the 18:1 fatty acid at the sn-2 position was dependent on the carbon chain at the sn-1 position.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Fosfatidilcolinas/análise
Fosfatidiletanolaminas/análise
Plasmalogênios/análise
[Mh] Termos MeSH secundário: Animais
Galinhas
Análise de Alimentos
Carne/análise
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphatidylcholines); 0 (Phosphatidylethanolamines); 0 (Plasmalogens)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE


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[PMID]:29331742
[Au] Autor:Li P; Zhang X; Zhang J; Yan Z; Zhang S; Chen S; Fang Y
[Ad] Endereço:Marine Fishery Institute of Zhejiang Province, Zhoushan 316021, Zhejiang Province, China; Marine Sciences College, Ningbo University, Ningbo 315211, Zhejiang Province, China.
[Ti] Título:A sensitive and selective immunoaffinity column clean up coupled to UPLC-MS/MS for determination of trace methyl-3-quinoxaline-2-carboxylic acid in animal tissues.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1074-1075:39-45, 2018 Feb 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This paper described a reliable and simple method for the selective determination of MQCA in animal tissues using ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). A highly targeted immunoaffinity column was used for sample purification after enzymatic hydrolysis. The purified extracts were analyzed by reversed-phase HPLC-MS/MS in positive ESI and multiple reaction monitoring mode. The calibration curves showed good linearity with correlation coefficient (r ) larger than 0.995. The average recoveries at the spiked levels of 0.5, 2.0 and 20µgkg were 90.2% to 103.5% with intra-day and inter-day relatives standard deviations (RSD, n=6) ranging from 1.8% to 6.7% and 3.5% to 7.6% respectively. The limit of quantification (LOQ) was 0.5µgkg , which can fulfil the maximum residue level (MRL) of 4.0µgkg stipulated by the Agricultural Minister of China and the requirement of the confirmatory criteria according to the European Commission Decision 2002/657/EC. The method is sensitive, accurate, convenient and rapid, and has been successfully applied in real samples.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Resíduos de Drogas/análise
Imunocromatografia/métodos
Quinoxalinas/análise
Quinoxalinas/isolamento & purificação
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Animais
Galinhas
Estabilidade de Medicamentos
Peixes
Modelos Lineares
Carne/análise
Quinoxalinas/química
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Quinoxalines); 0 (methyl-3-quinoxaline-2-carboxylic acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180115
[St] Status:MEDLINE


  5 / 28518 MEDLINE  
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[PMID]:29288907
[Au] Autor:Lytou AE; Nychas GE; Panagou EZ
[Ad] Endereço:Laboratory of Microbiology and Biotechnology of Foods, Department of Food Science and Human Nutrition, Faculty of Foods, Biotechnology and Development, Agricultural University of Athens, Iera Odos 75, Athens 11855, Greece.
[Ti] Título:Effect of pomegranate based marinades on the microbiological, chemical and sensory quality of chicken meat: A metabolomics approach.
[So] Source:Int J Food Microbiol;267:42-53, 2018 Feb 21.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Pomegranate juice is a product with enhanced functional properties that could be used as an alternative to traditional marination ingredients and effectively retard microbial growth along with providing an improved sensory result. In this study, two pomegranate based marinades were prepared for the marination of chicken breast fillets and the marinated samples were aerobically stored at 4 and 10°C for 9days. Raw, non-marinated chicken samples were used as control. Levels of total viable counts (TVC), Pseudomonas spp., Brochothrix thermosphacta, Enterobacteriaceae and lactic acid bacteria (LAB) were determined together with sensory assessment to evaluate the evolution of spoilage. The profile of organic acids and volatile compounds was also analyzed during storage. The shelf life of marinated samples was significantly extended compared to control samples at both storage temperatures (e.g., up to 5 and 6days for the pomegranate/lemon marinated samples stored at 4 and 10°C, respectively) as evaluated by both microbiological and sensory analyses. The profile of the organic acids and the volatilome of marinated and control samples were remarkably differentiated according to storage time, microbial load and sensory score. The findings of this study suggest that pomegranate juice could be used as a novel ingredient in marinades to improve the sensory attributes, while prolonging the shelf life of chicken meat.
[Mh] Termos MeSH primário: Conservação de Alimentos/normas
Carne/microbiologia
Metaboloma
Punicaceae/química
[Mh] Termos MeSH secundário: Animais
Bactérias/genética
Fenômenos Fisiológicos Bacterianos
Galinhas
Contagem de Colônia Microbiana
Armazenamento de Alimentos/normas
Seres Humanos
Carne/análise
Carne/normas
Metabolômica
Temperatura Ambiente
Compostos Orgânicos Voláteis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Volatile Organic Compounds)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171231
[St] Status:MEDLINE


  6 / 28518 MEDLINE  
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[PMID]:29256290
[Au] Autor:Elal Mus T; Cetinkaya F; Cibik R; Soyutemiz GE; Simsek H; Coplu N
[Ad] Endereço:1 Department of Food Processing, Vocational School of Keles, University of Uludag , Bursa , Turkey.
[Ti] Título:Pathogenicity determinants and antibiotic resistance profiles of enterococci from foods of animal origin in Turkey.
[So] Source:Acta Vet Hung;65(4):461-474, 2017 12.
[Is] ISSN:0236-6290
[Cp] País de publicação:Hungary
[La] Idioma:eng
[Ab] Resumo:In this study, the presence of genes responsible for the pathogenicity and antibiotic resistance profile of enterococci isolated from various foodstuffs of animal origin was investigated. The percentage prevalence of enterococci was 54.1% (203/375) and the average count was found to be 3.81 log cfu/ml-g. Species-specific primers revealed Enterococcus faecalis as the predominant species carrying one or more virulence-associated traits of efa, gelE, ace, esp and agg genetic markers. Only one E. faecium isolate (from milk) was positive for the esp gene. Regarding antibiotic resistance, the highest frequency of resistance was observed for tetracycline (21.7%), followed by quinupristin/dalfopristin (13.3%), ciprofloxacin (2.0%), penicillin (2.0%), linezolid (1.0%), ampicillin (1.0%), streptomycin (1.0%), and gentamicin (0.5%). Enterococcus faecalis showed a higher prevalence of antibiotic resistance than other enterococci. The percentage of multidrug resistance among the isolates was 3.4%. Twenty-nine E. faecalis isolates (26.6%) carrying one of the virulence-associated traits were at the same time resistant to at least one antibiotic. Our results show that foods of animal origin, including ready-to-eat products, may be reservoirs of antibiotic-resistant and potentially virulent enterococci.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Laticínios/microbiologia
Farmacorresistência Bacteriana
Enterococcus/efeitos dos fármacos
Carne/microbiologia
[Mh] Termos MeSH secundário: Animais
Bovinos
Microbiologia de Alimentos
Testes de Sensibilidade Microbiana
Aves Domésticas
Turquia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.1556/004.2017.044


  7 / 28518 MEDLINE  
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[PMID]:29278819
[Au] Autor:Cao X; Li X; Li J; Niu Y; Shi L; Fang Z; Zhang T; Ding H
[Ad] Endereço:College of Medicine, Jianghan University, Wuhan, 430056, People's Republic of China; Department of Pharmacy, Wuhan University, Wuhan, 430072, People's Republic of China.
[Ti] Título:Quantitative determination of carcinogenic mycotoxins in human and animal biological matrices and animal-derived foods using multi-mycotoxin and analyte-specific high performance liquid chromatography-tandem mass spectrometric methods.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1073:191-200, 2018 Jan 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A sensitive and reliable multi-mycotoxin-based method was developed to identify and quantify several carcinogenic mycotoxins in human blood and urine, as well as edible animal tissues, including muscle and liver tissue from swine and chickens, using liquid chromatography-tandem mass spectrometry (LC-MS/MS). For the toxicokinetic studies with individual mycotoxins, highly sensitive analyte-specific LC-MS/MS methods were developed for rat plasma and urine. Sample purification consisted of a rapid 'dilute and shoot' approach in urine samples, a simple 'dilute, evaporate and shoot' approach in plasma samples and a 'QuEChERS' procedure in edible animal tissues. The multi-mycotoxin and analyte-specific methods were validated in-house: The limits of detection (LOD) for the multi-mycotoxin and analyte-specific methods ranged from 0.02 to 0.41 µg/kg (µg/L) and 0.01 to 0.19 µg/L, respectively, and limits of quantification (LOQ) between 0.10 to 1.02 µg/kg (µg/L) and 0.09 to 0.47 µg/L, respectively. Apparent recoveries of the samples spiked with 0.25 to 4 µg/kg (µg/L) ranged from 60.1% to 109.8% with relative standard deviations below 15%. The methods were successfully applied to real samples. To the best of our knowledge, this is the first study carried out using a small group of patients from the Chinese population with hepatocellular carcinoma to assess their exposure to carcinogenic mycotoxins using biomarkers. Finally, the multi-mycotoxin method is a useful analytical method for assessing exposure to mycotoxins edible in animal tissues. The analyte-specific methods could be useful during toxicokinetic and toxicological studies.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Carne/análise
Micotoxinas/análise
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Animais
Carcinoma Hepatocelular/metabolismo
Galinhas
Seres Humanos
Limite de Detecção
Modelos Lineares
Neoplasias Hepáticas/metabolismo
Micotoxinas/sangue
Micotoxinas/urina
Reprodutibilidade dos Testes
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mycotoxins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE


  8 / 28518 MEDLINE  
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[PMID]:29326390
[Au] Autor:Hinney B
[Ad] Endereço:Department of Pathobiology, Institute of Parasitology, University of Veterinary Medicine Vienna, Veterinärplatz, Vienna, Austria.
[Ti] Título:The trend of raw meat-based diets: risks to people and animals.
[So] Source:Vet Rec;182(2):47-49, 2018 01 13.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Dieta
Carne/análise
[Mh] Termos MeSH secundário: Ração Animal/análise
Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1136/vr.k71


  9 / 28518 MEDLINE  
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[PMID]:28454589
[Au] Autor:Beyene T; Hayishe H; Gizaw F; Beyi AF; Abunna F; Mammo B; Ayana D; Waktole H; Abdi RD
[Ad] Endereço:Department of Biomedical Sciences, College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu, Ethiopia. takele.beyene@aau.edu.et.
[Ti] Título:Prevalence and antimicrobial resistance profile of Staphylococcus in dairy farms, abattoir and humans in Addis Ababa, Ethiopia.
[So] Source:BMC Res Notes;10(1):171, 2017 Apr 28.
[Is] ISSN:1756-0500
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Staphylococcus species cause mastitis and wound infection in livestock and food poisoning in humans through ingestion of contaminated foods, including meat and dairy products. They are evolving pathogens in that they readily acquire drug resistance, and multiple drug-resistant (MDR) isolates are increasing in human and veterinary healthcare. Therefore, this study was conducted to evaluate the prevalence of Staphylococci and their drug resistance in dairy farms and abattoir settings of Addis Ababa. METHODS: In this cross-sectional study, 193 samples of milk, meat, equipment and humans working in the dairy farms and abattoir were collected (dairy farms = 72 and abattoir sources = 121). Staphylococcus isolation and identification at the species level was done according to ISO-6888-3 using biochemical characteristics. An antimicrobial susceptibility test was conducted for 43 of the isolates using 15 antimicrobial agents commonly used for humans and livestock by the Kirby Bauer disk diffusion method following CLSI guidelines. RESULTS: Staphylococcus organism were isolated from 92 (47.7%) of the total 193 samples, 50% in the dairy farms and 46.3% in the abattoir. The isolated species were S. aureus (n = 31; 16.1%), S. intermedius (n = 21; 10.9%), S. hyicus (n = 16; 8.3%), and coagulase negative Staphylococcus (CNS) (n = 24; 12.4%). Gentamycin was effective drug as all isolates (n = 43; 100%) were susceptible to it and followed by kanamycin (n = 39; 90.7%). However, the majority of the isolates showed resistance to penicillin-G (95.3%), nalidixic acid (88.4%), cloxacillin (79.1%), vancomycin (65.1%) and cefoxitin (55.8%). Of the 15 S. aureus tested for drug susceptibility, 73.3% of them were phenotypically resistant to vancomycin (VRSA) and all of the 15 isolates showed multi-drug resistance (MDR) to >3 drugs. Also, all of the tested CNS (100%), S. hyicus (100%) and the majority of S. intermedius isolates (88.9%) developed MDR. CONCLUSION: Alarmingly, the Staphylococcus isolates circulating in the dairy farms and abattoir in the study area harbor MDR. High level of Staphylococcus species isolation from personnel and equipment besides food (meat and milk) samples in dairy farms and abattoir settings reveals that the hygiene practice in the dairy farm and abattoir is substandard. Prudent drug use and improved hygienic practice is recommended in the dairy farms and abattoir to safeguard the public from the risk of acquiring infections and MDR pathogenic Staphylococcus.
[Mh] Termos MeSH primário: Farmacorresistência Bacteriana/genética
Mastite Bovina/epidemiologia
Staphylococcus aureus Resistente à Meticilina/genética
Saúde do Trabalhador/educação
Infecções Estafilocócicas/epidemiologia
Staphylococcus/genética
[Mh] Termos MeSH secundário: Matadouros
Criação de Animais Domésticos
Animais
Antibacterianos/farmacologia
Técnicas de Tipagem Bacteriana
Bovinos
Estudos Transversais
Etiópia/epidemiologia
Fazendas
Feminino
Gentamicinas/farmacologia
Seres Humanos
Canamicina/farmacologia
Mastite Bovina/microbiologia
Mastite Bovina/transmissão
Carne/microbiologia
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Staphylococcus aureus Resistente à Meticilina/isolamento & purificação
Testes de Sensibilidade Microbiana
Leite/microbiologia
Prevalência
Infecções Estafilocócicas/microbiologia
Infecções Estafilocócicas/transmissão
Staphylococcus/classificação
Staphylococcus/efeitos dos fármacos
Staphylococcus/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Gentamicins); 59-01-8 (Kanamycin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1186/s13104-017-2487-y


  10 / 28518 MEDLINE  
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[PMID]:29241059
[Au] Autor:Del Bianchi A Cruz M; Fernandes MAM; de C Braga PA; Monteiro ALG; Daniel D; Reyes FGR
[Ad] Endereço:Department of Food Science, School of Food Engineering, University of Campinas - UNICAMP, Rua Monteiro Lobato, 80, 13083-862, Campinas, SP, Brazil.
[Ti] Título:Moxidectin residues in lamb tissues: Development and validation of analytical method by UHPLC-MS/MS.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1072:390-396, 2018 Jan 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The development and validation of a throughput method for the quantitation of moxidectin residues in lamb target tissues (muscle, kidney, liver and fat) was conducted using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). To achieve higher recovery of the analyte from the matrices, a modified QuEChERS method was used for sample preparation. The chromatographic separation was achieved using a Zorbax Eclipse Plus C18 RRHD column with a mobile phase comprising 5mM ammonium formate solution +0.1% formic acid (A) and acetonitrile +0.1% formic acid (B) in a linear gradient program. Method validation was performed based on the Commission Decision 2002/657/EC and VICH GL49. To quantify the analyte, matrix-matched analytical curves were constructed with spiked blank tissues, with a limit of quantitation of 5ngg and limit of detection of 1.5ngg for all matrices. The linearity, decision limit, detection capability accuracy, and inter- and intra-day repeatability of the method are reported. The method was successfully applied to incurred lamb tissue samples (muscle, liver, kidney and fat) in a concentration range from 5 to 200µgkg , which demonstrated its suitability for monitoring moxidectin residues in lamb tissues in health surveillance programs, as well as for pharmacokinetics and residue depletion studies.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Resíduos de Drogas/análise
Macrolídeos/análise
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Animais
Resíduos de Drogas/química
Resíduos de Drogas/farmacocinética
Rim/química
Rim/metabolismo
Limite de Detecção
Modelos Lineares
Macrolídeos/química
Macrolídeos/farmacocinética
Carne/análise
Músculo Esquelético/química
Músculo Esquelético/metabolismo
Reprodutibilidade dos Testes
Ovinos
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Macrolides); 51570-36-6 (milbemycin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE



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