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Pesquisa : G07.203.650 [Categoria DeCS]
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[PMID]:28467945
[Au] Autor:Sharif A; Prevot V
[Ad] Endereço:INSERM, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Center, UMR_S1172, School of Medicine, University of Lille, F-59000 Lille, France.
[Ti] Título:When Size Matters: How Astrocytic Processes Shape Metabolism.
[So] Source:Cell Metab;25(5):995-996, 2017 May 02.
[Is] ISSN:1932-7420
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The hypothalamic control of metabolism appears to be a puzzle that cannot be explained by neuronal function alone. Zhang and colleagues (2017) add a few new pieces by demonstrating that astrocytes critically modulate neural circuits controlling energy homeostasis through nutritional-status-dependent morphological plasticity and IKKß/NF-κB signaling, which modulate extracellular neurotransmitter bioavailability.
[Mh] Termos MeSH primário: Astrócitos/metabolismo
Hipotálamo/fisiologia
Quinase I-kappa B/metabolismo
NF-kappa B/metabolismo
Transdução de Sinais
[Mh] Termos MeSH secundário: Animais
Astrócitos/citologia
Metabolismo Energético
Homeostase
Seres Humanos
Rede Nervosa
Fenômenos Fisiológicos da Nutrição
Estado Nutricional
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NF-kappa B); EC 2.7.11.10 (I-kappa B Kinase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


  2 / 24404 MEDLINE  
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[PMID]:29368464
[Au] Autor:Neswald E
[Ti] Título:Food Fights: Human Experiments in Late Nineteenth-Century Nutrition Physiology.
[So] Source:Clio Med;95:170-93, 2016.
[Is] ISSN:0045-7183
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Experimentação Humana/história
Fenômenos Fisiológicos da Nutrição
Sujeitos da Pesquisa/história
[Mh] Termos MeSH secundário: Alimentos/história
História do Século XIX
Seres Humanos
Estado Nutricional
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM; QIS
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


  3 / 24404 MEDLINE  
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[PMID]:27770569
[Au] Autor:Corrales-Carvajal VM; Faisal AA; Ribeiro C
[Ad] Endereço:Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal.
[Ti] Título:Internal states drive nutrient homeostasis by modulating exploration-exploitation trade-off.
[So] Source:Elife;5, 2016 10 22.
[Is] ISSN:2050-084X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Internal states can profoundly alter the behavior of animals. A quantitative understanding of the behavioral changes upon metabolic challenges is key to a mechanistic dissection of how animals maintain nutritional homeostasis. We used an automated video tracking setup to characterize how amino acid and reproductive states interact to shape exploitation and exploration decisions taken by adult . We find that these two states have specific effects on the decisions to stop at and leave proteinaceous food patches. Furthermore, the internal nutrient state defines the exploration-exploitation trade-off: nutrient-deprived flies focus on specific patches while satiated flies explore more globally. Finally, we show that olfaction mediates the efficient recognition of yeast as an appropriate protein source in mated females and that octopamine is specifically required to mediate homeostatic postmating responses without affecting internal nutrient sensing. Internal states therefore modulate specific aspects of exploitation and exploration to change nutrient selection.
[Mh] Termos MeSH primário: Drosophila melanogaster/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Alimentar
Preferências Alimentares
Homeostase
Fenômenos Fisiológicos da Nutrição
Comportamento Sexual Animal
Olfato
Gravação em Vídeo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171224
[Lr] Data última revisão:
171224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  4 / 24404 MEDLINE  
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[PMID]:29044230
[Au] Autor:De Rosa V; La Cava A; Matarese G
[Ad] Endereço:Laboratorio di Immunologia, Istituto per l'Endocrinologia e l'Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy.
[Ti] Título:Metabolic pressure and the breach of immunological self-tolerance.
[So] Source:Nat Immunol;18(11):1190-1196, 2017 Oct 18.
[Is] ISSN:1529-2916
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The prevalence of autoimmune disorders in affluent countries has reached epidemic proportions. Over the past 50 years, a reverse trend between the frequency of infectious diseases and the incidence of autoimmune and allergic diseases led to the so-called 'hygiene hypothesis'. Given the epidemiological evidence and recent experimental data, we propose that this concept should also include metabolic pressure secondary to exposure to excessive daily caloric intake and overnutrition. We discuss how metabolic workload can modulate immunological tolerance and review the molecular mechanisms and the state of the art of the field. We also critically evaluate possibilities for restoring immunological homeostasis under conditions of metabolic pressure.
[Mh] Termos MeSH primário: Doenças Autoimunes/imunologia
Doenças Autoimunes/metabolismo
Homeostase/imunologia
Hipótese da Higiene
Tolerância a Antígenos Próprios/imunologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Redes e Vias Metabólicas/imunologia
Modelos Imunológicos
Fenômenos Fisiológicos da Nutrição/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1038/ni.3851


  5 / 24404 MEDLINE  
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[PMID]:28903979
[Au] Autor:Ruan HB; Ma Y; Torres S; Zhang B; Feriod C; Heck RM; Qian K; Fu M; Li X; Nathanson MH; Bennett AM; Nie Y; Ehrlich BE; Yang X
[Ad] Endereço:Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
[Ti] Título:Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation.
[So] Source:Genes Dev;31(16):1655-1665, 2017 Aug 15.
[Is] ISSN:1549-5477
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Starvation induces liver autophagy, which is thought to provide nutrients for use by other organs and thereby maintain whole-body homeostasis. Here we demonstrate that O-linked ß-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is required for glucagon-stimulated liver autophagy and metabolic adaptation to starvation. Genetic ablation of OGT in mouse livers reduces autophagic flux and the production of glucose and ketone bodies. Upon glucagon-induced calcium signaling, calcium/calmodulin-dependent kinase II (CaMKII) phosphorylates OGT, which in turn promotes O-GlcNAc modification and activation of Ulk proteins by potentiating AMPK-dependent phosphorylation. These findings uncover a signaling cascade by which starvation promotes autophagy through OGT phosphorylation and establish the importance of O-GlcNAc signaling in coupling liver autophagy to nutrient homeostasis.
[Mh] Termos MeSH primário: Autofagia
Sinalização do Cálcio
Fígado/metabolismo
N-Acetilglucosaminiltransferases/metabolismo
Fenômenos Fisiológicos da Nutrição
[Mh] Termos MeSH secundário: Adaptação Biológica
Animais
Proteína 5 Relacionada à Autofagia/fisiologia
Proteína Homóloga à Proteína-1 Relacionada à Autofagia/metabolismo
Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/metabolismo
Células Cultivadas
Glucagon/farmacologia
Células HEK293
Células HeLa
Seres Humanos
Receptores de Inositol 1,4,5-Trifosfato/metabolismo
Fígado/efeitos dos fármacos
Fígado/enzimologia
Camundongos Endogâmicos C57BL
N-Acetilglucosaminiltransferases/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Atg5 protein, mouse); 0 (Autophagy-Related Protein 5); 0 (Inositol 1,4,5-Trisphosphate Receptors); 9007-92-5 (Glucagon); EC 2.4.1.- (N-Acetylglucosaminyltransferases); EC 2.7.11.1 (Autophagy-Related Protein-1 Homolog); EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171029
[Lr] Data última revisão:
171029
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1101/gad.305441.117


  6 / 24404 MEDLINE  
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[PMID]:28895454
[Au] Autor:Friedrich M; Goluch-Koniuszy Z
[Ad] Endereço:Western Pomeranian University of Technology, Faculty of Food Sciences and Fisheries, Department of Human Nutrition Physiology, Szczecin, Poland
[Ti] Título:The effectiveness of nutritional education among women aged 60-85 on the basis of anthropometric parameters and lipid profiles
[So] Source:Rocz Panstw Zakl Hig;68(3):253-260, 2017.
[Is] ISSN:0035-7715
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Background: After several years of experience with guiding of an original program on health-promoting nutritional education for women during menopause, which by inducing changes in nutritional behaviour resulted in many favorable health promoting effects, on request of the students of the Association of Third Age University, an original educational program "Comprehensive stimulation of senior citizens to activity" was developed out and implemented. Objective: The objective of this study was to assess the effectiveness of four-month nutritional education and adjustments in diets of women aged 60-85, on the basis of the measurements of the selected lipid parameters in their blood tests Material and methods: This research project was joined by 37 female subjects aged 60-85, who are the members of the University of the Third Age in Szczecin, and whose average BMI was 31.7 kg/m2. Before the nutritional education commenced and after it was completed, the female subjects' nutritional status was assessed (BMI, WC, WHR, WHtR) and the energy and nutritional value of their diets was examined based on the subjects' regular journalkeeping. Keys' atherogenic score in their diets were also computed. Results: The applied nutritional education led to changes in the energy and nutritional value of the female subjects' diets, which specifically improved their anthropometric parameters and the resulting BMI, WC and WHtR parameters. This fact was also reflected in a substantial decrease of the glucose level and a substantial increase of HDL-C level in the blood of the examined female subjects, as well as in the improvements in the assessed parameters TC/HDL-C, LDL-C/ HDL-C, TG/HDL-C. Conclusions: The analysis of the results allows to confirm, that the four-month nutritional education of elderly women resulted in changes of their erroneous dietary habits and an improvement in their nutrition.
[Mh] Termos MeSH primário: Preferências Alimentares/psicologia
Educação em Saúde
Conhecimentos, Atitudes e Prática em Saúde
Obesidade/prevenção & controle
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Antropometria
Índice de Massa Corporal
Carboidratos da Dieta/administração & dosagem
Gorduras na Dieta/administração & dosagem
Proteínas na Dieta/administração & dosagem
Feminino
Seres Humanos
Lipídeos/sangue
Meia-Idade
Inquéritos Nutricionais
Fenômenos Fisiológicos da Nutrição
Obesidade/sangue
Polônia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Carbohydrates); 0 (Dietary Fats); 0 (Dietary Proteins); 0 (Lipids)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170913
[St] Status:MEDLINE


  7 / 24404 MEDLINE  
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[PMID]:28892825
[Au] Autor:Merle BMJ; Silver RE; Rosner B; Seddon JM
[Ad] Endereço:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Lifelong Exposures, Health and Aging, Bordeaux, France.
[Ti] Título:Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration.
[So] Source:Invest Ophthalmol Vis Sci;58(11):4569-4578, 2017 Sep 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: There is growing evidence of the importance of nutrition in age-related macular degeneration (AMD), but no prospective studies have explored the impact of vitamin D. We evaluated the association between vitamin D intake and progression to advanced AMD. Methods: Among 2146 participants (3965 eyes), 541 (777 eyes) progressed from early or intermediate AMD to advanced disease (mean follow-up: 9.4 years) based on ocular imaging. Nutrients were log transformed and calorie adjusted. Survival analysis was used to assess associations between incident advanced disease and vitamin D intake. Neovascular disease (NV) and geographic atrophy (GA) were evaluated separately. Combined effects of dietary vitamin D and calcium were assessed based on high or low consumption of each nutrient. Results: There was a lower risk of progression to advanced AMD in the highest versus lowest quintile of dietary vitamin D intake after adjustment for demographic, behavioral, ocular, and nutritional factors (hazard ratio [HR]: 0.60; 95% confidence interval [CI]: 0.43-0.83; P trend = 0.0007). Similar results were observed for NV (HR: 0.59; 95% CI: 0.39-0.89; P trend = 0.005) but not GA (HR: 0.83; 95% CI: 0.53-1.30; P trend = 0.35). A protective effect was observed for advanced AMD among participants with high vitamin D and low calcium compared to the group with low levels for each nutrient (HR: 0.67; 95% CI: 0.50-0.88; P = 0.005). When supplement use was considered, the effect was in the protective direction but was not significant. Conclusions: A diet rich in vitamin D may prevent or delay progression to advanced AMD, especially NV. Additional exploration is needed to elucidate the potential protective role of vitamin D and its contribution to reducing visual loss.
[Mh] Termos MeSH primário: Dieta
Atrofia Geográfica/prevenção & controle
Vitamina D/administração & dosagem
Vitaminas/administração & dosagem
Degeneração Macular Exsudativa/prevenção & controle
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Registros de Dieta
Suplementos Nutricionais
Progressão da Doença
Ingestão de Energia
Feminino
Seguimentos
Atrofia Geográfica/epidemiologia
Seres Humanos
Incidência
Masculino
Meia-Idade
Fenômenos Fisiológicos da Nutrição
Estudos Prospectivos
Fatores de Risco
Degeneração Macular Exsudativa/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vitamins); 1406-16-2 (Vitamin D)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21673


  8 / 24404 MEDLINE  
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[PMID]:28886080
[Au] Autor:Curtis PD
[Ad] Endereço:Department of Biology, University of Mississippi, University, MS, United States of America.
[Ti] Título:Stalk formation of Brevundimonas and how it compares to Caulobacter crescentus.
[So] Source:PLoS One;12(9):e0184063, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Caulobacter crescentus cell extension known as a stalk represents an unusual bacterial morphology. C. crescentus produces stalks under multiple nutrient conditions, but the length of the stalk is increased in response to phosphate starvation. However, the exact function of the stalk is not known, nor is it known how much stalk biogenesis or function is conserved with other stalked bacteria. Work presented here shows that many organisms in the Caulobacter genus and the next closest genus (Brevundimonas) generally do not synthesize stalks in the relatively-rich PYE growth medium, suggesting that the synthesis of a stalk under nutrient-rich conditions by C. crescentus may be the exception instead of the norm among its phylogenetic group. Brevundimonas subvibrioides can be induced to synthesize stalks by genetically mimicking phosphate starvation conditions, indicating stalk synthesis in this organism may be performed on an as-need basis. This mutation, however, does not appear to increase the incidence of holdfast synthesis. While B. subvibrioides stalks appear to be synthesized with the same polarity with respect to holdfast as C. crescentus stalks, evidence is presented that suggests B. subvibrioides may disassemble stalks when they are no longer needed. Many homologs of C. crescentus genes encoding stalk-associated proteins are absent in the B. subvibrioides genome, and B. subvibrioides PstA-GFP as well as C. crescentus StpX-GFP are able to enter the B. subvibrioides stalk compartment, calling into question the level of compartmentalization of the B. subvibrioides stalk. In summary, this work begins to address how much the C. crescentus model for this unusual morphological adaptation can be extended to related organisms.
[Mh] Termos MeSH primário: Alphaproteobacteria/ultraestrutura
Caulobacter crescentus/ultraestrutura
[Mh] Termos MeSH secundário: Alphaproteobacteria/fisiologia
Caulobacter crescentus/fisiologia
Evolução Molecular
Deleção de Genes
Mutação
Fenômenos Fisiológicos da Nutrição
Proteínas de Ligação a Fosfato/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphate-Binding Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184063


  9 / 24404 MEDLINE  
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[PMID]:28873424
[Au] Autor:Pfuhlmann K; Pfluger PT; Schriever SC; Müller TD; Tschöp MH; Stemmer K
[Ad] Endereço:Research Unit NeuroBiology of Diabetes, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.
[Ti] Título:Dual specificity phosphatase 6 deficiency is associated with impaired systemic glucose tolerance and reversible weight retardation in mice.
[So] Source:PLoS One;12(9):e0183488, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Here, we aimed to investigate the potential role of DUSP6, a dual specificity phosphatase, that specifically inactivates extracellular signal-regulated kinase (ERK), for the regulation of body weight and glucose homeostasis. We further assessed whether metabolic challenges affect Dusp6 expression in selected brain areas or white adipose tissue. Hypothalamic Dusp6 mRNA levels remained unchanged in chow-fed lean vs. high fat diet (HFD) fed obese C57Bl/6J mice, and in C57Bl/6J mice undergoing prolonged fasting or refeeding with fat free diet (FFD) or HFD. Similarly, Dusp6 expression levels were unchanged in selected brain regions of Lepob mice treated with 1 mg/kg of leptin for 6 days, compared to pair-fed or saline-treated Lepob controls. Dusp6 expression levels remained unaltered in vitro in primary adipocytes undergoing differentiation, but were increased in eWAT of HFD-fed obese C57Bl/6J mice, compared to chow-fed lean controls. Global chow-fed DUSP6 KO mice displayed reduced body weight and lean mass and slightly increased fat mass at a young age, which is indicative for early-age weight retardation. Subsequent exposure to HFD led to a significant increase in lean mass and body weight in DUSP6 deficient mice, compared to WT controls. Nevertheless, after 26 weeks of high-fat diet exposure, we observed comparable body weight, fat and lean mass in DUSP6 WT and KO mice, suggesting overall normal susceptibility to develop obesity. In line with the increased weight gain to compensate for early-age weight retardation, HFD-fed DUSP6 KO displayed increased expression levels of anabolic genes involved in lipid and cholesterol metabolism in the epididymal white adipose tissue (eWAT), compared to WT controls. Glucose tolerance was perturbed in both chow-fed lean or HFD-fed obese DUSP6 KO, compared to their respective WT controls. Overall, our data indicate that DUSP6 deficiency has limited impact on the regulation of energy metabolism, but impairs systemic glucose tolerance. Our data are in conflict to earlier reports that propose protection from diet-induced obesity and glucose intolerance in DUSP6 deficient mice. Reasons for the discrepancies remain elusive, but may entail differential genetic backgrounds, environmental factors such as the type and source of HFD, or alterations in the gut microbiome between facilities.
[Mh] Termos MeSH primário: Peso Corporal
Fosfatase 6 de Especificidade Dupla/deficiência
Intolerância à Glucose/enzimologia
[Mh] Termos MeSH secundário: Tecido Adiposo Branco/metabolismo
Animais
Composição Corporal
Dieta Hiperlipídica
Fosfatase 6 de Especificidade Dupla/genética
Fosfatase 6 de Especificidade Dupla/metabolismo
Epididimo/metabolismo
Jejum
Perfilação da Expressão Gênica
Intolerância à Glucose/complicações
Intolerância à Glucose/genética
Intolerância à Glucose/patologia
Homeostase
Leptina/metabolismo
Metabolismo dos Lipídeos
Masculino
Camundongos Endogâmicos C57BL
Camundongos Knockout
Fenômenos Fisiológicos da Nutrição
Obesidade/complicações
Obesidade/genética
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Leptin); 0 (RNA, Messenger); EC 3.1.3.48 (Dual Specificity Phosphatase 6)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183488


  10 / 24404 MEDLINE  
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[PMID]:28820082
[Au] Autor:Selin JZ; Lindblad BE; Bottai M; Morgenstern R; Wolk A
[Ad] Endereço:1Division of Nutritional Epidemiology,Institute of Environmental Medicine,Karolinska Institutet,SE-17177 Stockholm,Sweden.
[Ti] Título:High-dose B-vitamin supplements and risk for age-related cataract: a population-based prospective study of men and women.
[So] Source:Br J Nutr;118(2):154-160, 2017 Jul.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Previous studies that have investigated the association between B-vitamin supplement use and risk for cataract yield conflicting results. The aim of this study was to examine the association between use of high-dose B-vitamin supplements (approximately 10 times recommended daily intake) and risk for age-related cataract in a population-based prospective study of 13 757 women from the Swedish Mammography Cohort and 22 823 men from the Cohort of Swedish Men. Dietary supplement use and potential confounders were assessed using a questionnaire at baseline. Information on cataract diagnosis and extraction was obtained through linkage to registers. During the follow-up period between January 1998 and December 2011, we identified 8395 cataract cases (3851 for women and 4544 for men). The use of B vitamins plus other supplements and B vitamins only was associated with 9 % (95 % CI 2, 17) and 27 % (95 % CI 12, 43) increased risk for cataract, respectively. The hazard ratios for use of B vitamins only and risk for cataract stratified by different age groups were as follows: <60 years: 1·88 (95 % CI 1·47, 2·39); 60-69 years: 1·21 (95 % CI 0·96, 1·53); and ≥70 years: 1·09 (95 % CI 0·91, 1·31) (P interaction=0·002). Our results suggest that the use of high-dose B-vitamin supplements was associated with an increased risk for cataract. This association might be confined to younger participants.
[Mh] Termos MeSH primário: Envelhecimento
Catarata/induzido quimicamente
Catarata/epidemiologia
Complexo Vitamínico B/administração & dosagem
Complexo Vitamínico B/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Estudos de Coortes
Dieta
Suplementos Nutricionais
Feminino
Seres Humanos
Estilo de Vida
Masculino
Meia-Idade
Fenômenos Fisiológicos da Nutrição
Estudos Prospectivos
Recomendações Nutricionais
Fatores de Risco
Inquéritos e Questionários
Suécia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
12001-76-2 (Vitamin B Complex)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517001994



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde