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Pesquisa : G07.203.650.170 [Categoria DeCS]
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[PMID]:28461198
[Au] Autor:Hagger MS; Trost N; Keech JJ; Chan DKC; Hamilton K
[Ad] Endereço:School of Psychology and Speech Pathology, Health Psychology and Behavioural Medicine Research Group, Curtin University, Perth, Western Australia, Australia; School of Applied Psychology and Menzies Health Institute Queensland, Griffith University, Brisbane, Queensland, Australia; Faculty of Sport a
[Ti] Título:Predicting sugar consumption: Application of an integrated dual-process, dual-phase model.
[So] Source:Appetite;116:147-156, 2017 09 01.
[Is] ISSN:1095-8304
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Excess consumption of added dietary sugars is related to multiple metabolic problems and adverse health conditions. Identifying the modifiable social cognitive and motivational constructs that predict sugar consumption is important to inform behavioral interventions aimed at reducing sugar intake. We tested the efficacy of an integrated dual-process, dual-phase model derived from multiple theories to predict sugar consumption. Using a prospective design, university students (N = 90) completed initial measures of the reflective (autonomous and controlled motivation, intentions, attitudes, subjective norm, perceived behavioral control), impulsive (implicit attitudes), volitional (action and coping planning), and behavioral (past sugar consumption) components of the proposed model. Self-reported sugar consumption was measured two weeks later. A structural equation model revealed that intentions, implicit attitudes, and, indirectly, autonomous motivation to reduce sugar consumption had small, significant effects on sugar consumption. Attitudes, subjective norm, and, indirectly, autonomous motivation to reduce sugar consumption predicted intentions. There were no effects of the planning constructs. Model effects were independent of the effects of past sugar consumption. The model identified the relative contribution of reflective and impulsive components in predicting sugar consumption. Given the prominent role of the impulsive component, interventions that assist individuals in managing cues-to-action and behavioral monitoring are likely to be effective in regulating sugar consumption.
[Mh] Termos MeSH primário: Regulação do Apetite
Açúcares da Dieta/administração & dosagem
Preferências Alimentares
Dieta Saudável
Modelos Biológicos
Modelos Psicológicos
Cooperação do Paciente
[Mh] Termos MeSH secundário: Adaptação Psicológica
Adulto
Austrália
Açúcares da Dieta/efeitos adversos
Feminino
Preferências Alimentares/psicologia
Conhecimentos, Atitudes e Prática em Saúde
Dieta Saudável/psicologia
Seres Humanos
Comportamento Impulsivo
Intenção
Masculino
Cooperação do Paciente/psicologia
Pacientes Desistentes do Tratamento
Autorrelato
Autocontrole/psicologia
Estudantes
Universidades
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Dietary Sugars)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:28461197
[Au] Autor:Abebe Z; Haki GD; Baye K
[Ad] Endereço:Center for Food Science and Nutrition, College of Natural Sciences, POBOX 1176, Addis Ababa University, Addis Ababa, Ethiopia.
[Ti] Título:Child feeding style is associated with food intake and linear growth in rural Ethiopia.
[So] Source:Appetite;116:132-138, 2017 09 01.
[Is] ISSN:1095-8304
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Little is known about mother-child feeding interactions and how this is associated with food intake and linear growth. OBJECTIVE: To characterize mother-child feeding styles and investigate their associations with accepted mouthful and linear growth in west Gojam, rural Ethiopia. SUBJECTS/DESIGN: Two, in-home, meal observations of children aged 12-23 months (n = 100) were video-taped. The number of mouthful accepted was counted and the caregiver/child feeding styles were coded into positive/negative categories of self-feeding, responsive-feeding, active-feeding, social-behavior and distraction. Data on socio-demographic characteristics, child feeding practices, perception about child's overall appetite, and strategies adopted to overcome food refusal were collected through questionnaire-based interviews. Child and mothers' anthropometric measurements were also taken. RESULTS: Stunting was highly prevalent (48%) and the number of mouthful accepted was very low. Offering breastmilk and threatening to harm were the main strategies adopted to overcome food refusal. Although all forms of feeding style were present, active positive feeding style was dominant (90%) and was positively associated with mouthful accepted. Talking with non-feeding partner (64%), and domestic animals (24%) surrounding the feeding place were common distractions of feeding. Feeding was mostly terminated by caregivers (75%), often prematurely. Overall, caregivers of stunted children had poorer complementary- and breast-feeding practices and were less responsive to child's hunger and satiation cues (P < 0.05). Positive responsive feeding behaviors were associated with child's number of mouthful accepted (r = 0.27; P = 0.007) and stunting (r = 0.4; P < 0.001). CONCLUSION: Low complementary food intake in this setting is associated with caregivers' feeding style and stunting. Nutrition interventions that reinforce messages of optimal infant and young child feeding and integrate the promotion of responsive feeding behaviors are needed.
[Mh] Termos MeSH primário: Regulação do Apetite
Comportamento Alimentar
Transtornos de Alimentação na Infância/etiologia
Transtornos do Crescimento/etiologia
Fenômenos Fisiológicos da Nutrição do Lactente
Desnutrição/etiologia
Saúde da População Rural
[Mh] Termos MeSH secundário: Regulação do Apetite/etnologia
Desenvolvimento Infantil
Educação Infantil/etnologia
Estudos Transversais
Países em Desenvolvimento
Ingestão de Energia/etnologia
Etiópia
Comportamento Alimentar/etnologia
Transtornos de Alimentação na Infância/etnologia
Transtornos de Alimentação na Infância/fisiopatologia
Transtornos de Alimentação na Infância/prevenção & controle
Feminino
Transtornos do Crescimento/epidemiologia
Transtornos do Crescimento/etnologia
Transtornos do Crescimento/prevenção & controle
Seres Humanos
Lactente
Almoço/etnologia
Masculino
Desnutrição/etnologia
Desnutrição/fisiopatologia
Desnutrição/prevenção & controle
Mães
Prevalência
Saúde da População Rural/etnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:28457982
[Au] Autor:Joki A; Mäkelä J; Fogelholm M
[Ad] Endereço:Department of Food and Environmental Sciences, University of Helsinki, P.O. Box 66, Building: 2029, Helsingin Yliopisto, Finland. Electronic address: anu.joki@helsinki.fi.
[Ti] Título:Permissive flexibility in successful lifelong weight management: A qualitative study among Finnish men and women.
[So] Source:Appetite;116:157-163, 2017 09 01.
[Is] ISSN:1095-8304
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Maintaining normal weight in the current obesogenic environment is a challenge. However, some people can do it. More insight is needed to understand how and why some people succeed in long-term weight maintenance. This study uses a rare, qualitative approach by describing the thoughts of successful weight management and self-perceived requirements for success in weight maintenance. We interviewed 39 individuals who have maintained normal weight for their entire lives (men and women). The content analysis revealed a main theme: flexible, permissive and conscious self-regulation, which was divided into two subthemes (eating-related behavior and weight-related behavior). The informants reported certain routines that supported their weight management: regular eating, sufficient meal sizes, eating in response to hunger, healthy and vegetable-rich diet along with moderate feasting and flexible eating restriction. Flexibility in routines allowed freedom in their eating behavior. In addition, informants regarded themselves as physically active, and they enjoyed regular exercise. Regular weighing was generally considered unnecessary. Normal weight was regarded as a valuable and worthwhile issue, and most of the informants worked to keep their weight stable. Although the perceived workload varied among informants, the weight management strategies were similar. It was crucial to be conscious of the balance between eating and energy consumption. Further, flexibility characterized their behavior and was the basis of successful weight management. Women were more aware of weight control practices and knowledge than men, but otherwise, women and men reported similar weight management methods and attitudes. In conclusion, the interviewees who have maintained the normal weight had created a personal weight-management support environment where weight management was a lifestyle.
[Mh] Termos MeSH primário: Adaptação Psicológica
Manutenção do Peso Corporal
Exercício
Estilo de Vida Saudável
Modelos Psicológicos
Cooperação do Paciente
[Mh] Termos MeSH secundário: Adulto
Idoso
Regulação do Apetite
Índice de Massa Corporal
Exercício/psicologia
Comportamento Alimentar/psicologia
Feminino
Finlândia
Conhecimentos, Atitudes e Prática em Saúde
Seres Humanos
Masculino
Refeições
Meia-Idade
Cooperação do Paciente/psicologia
Pesquisa Qualitativa
Autorrelato
Autocontrole/psicologia
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:28455261
[Au] Autor:Cheval B; Audrin C; Sarrazin P; Pelletier L
[Ad] Endereço:Univ. Grenoble Alpes, SENS, F-38000 Grenoble, France; Faculty of Psychology and Educational Sciences, University of Geneva, Switzerland; School of Psychology, University of Ottawa, Canada. Electronic address: boris.cheval@unige.ch.
[Ti] Título:When hunger does (or doesn't) increase unhealthy and healthy food consumption through food wanting: The distinctive role of impulsive approach tendencies toward healthy food.
[So] Source:Appetite;116:99-107, 2017 09 01.
[Is] ISSN:1095-8304
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Hunger indirectly triggers unhealthy high-calorie food consumption through its positive effect on the incentive value (or "wanting") for food. Yet, not everyone consumes unhealthy food in excess, suggesting that some individuals react differently when they are exposed to unhealthy high-calorie food, even when they are hungry. The purpose of the present study was to investigate whether individual differences in impulsive approach tendencies toward food may explain how, and for whom, hunger will influence unhealthy food consumption through its effect on food wanting. A complementary goal was to explore whether these individual differences also influence healthy food consumption. METHODS: Students (N = 70) completed a questionnaire measuring their hunger and food wanting. Then, they performed a manikin task designed to evaluate their impulsive approach tendencies toward unhealthy food (IAUF) and healthy food (IAHF). The main outcomes variables were the amount of sweets (i.e., unhealthy food) and raisins (i.e., healthy food) consumed during a product-testing task. RESULTS: A moderated mediation analysis revealed that the indirect effect of hunger on unhealthy consumption through food wanting was moderated by IAHF. Specifically, hunger positively predicted sweets consumption through wanting for food among individuals with a low or moderate, but not high IAHF. The moderated mediation pattern was, however, not confirmed for IAUF. Finally, results revealed a direct and positive effect of IAHF on raisins consumption. CONCLUSION: These findings showed that IAHF play a protective role by preventing hunger to indirectly increase unhealthy food consumption through wanting for food. It confirms the importance of considering how individuals may differ in their impulsive approach tendencies toward food to better understand why some individuals will increase their unhealthy food intake when they are hungry, whereas other will not.
[Mh] Termos MeSH primário: Regulação do Apetite
Preferências Alimentares
Conhecimentos, Atitudes e Prática em Saúde
Dieta Saudável
Modelos Psicológicos
Cooperação do Paciente
Autocontrole
[Mh] Termos MeSH secundário: Adolescente
Fenômenos Fisiológicos da Nutrição do Adolescente
Adulto
Feminino
Seres Humanos
Comportamento Impulsivo
Masculino
Ontário
Sobrepeso/etiologia
Sobrepeso/prevenção & controle
Sobrepeso/psicologia
Autorrelato
Estudantes
Universidades
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:28467924
[Au] Autor:Søberg S; Sandholt CH; Jespersen NZ; Toft U; Madsen AL; von Holstein-Rathlou S; Grevengoed TJ; Christensen KB; Bredie WLP; Potthoff MJ; Solomon TPJ; Scheele C; Linneberg A; Jørgensen T; Pedersen O; Hansen T; Gillum MP; Grarup N
[Ad] Endereço:Section for Metabolic Imaging and Liver Metabolism, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Centre o
[Ti] Título:FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans.
[So] Source:Cell Metab;25(5):1045-1053.e6, 2017 May 02.
[Is] ISSN:1932-7420
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The liking and selective ingestion of palatable foods-including sweets-is biologically controlled, and dysfunction of this regulation may promote unhealthy eating, obesity, and disease. The hepatokine fibroblast growth factor 21 (FGF21) reduces sweet consumption in rodents and primates, whereas knockout of Fgf21 increases sugar consumption in mice. To investigate the relevance of these findings in humans, we genotyped variants in the FGF21 locus in participants from the Danish Inter99 cohort (n = 6,514) and examined their relationship with a detailed range of food and ingestive behaviors. This revealed statistically significant associations between FGF21 rs838133 and increased consumption of candy, as well as nominal associations with increased alcohol intake and daily smoking. Moreover, in a separate clinical study, plasma FGF21 levels increased acutely after oral sucrose ingestion and were elevated in fasted sweet-disliking individuals. These data suggest the liver may secrete hormones that influence eating behavior.
[Mh] Termos MeSH primário: Doces
Fatores de Crescimento de Fibroblastos/genética
Preferências Alimentares
Polimorfismo Genético
Açúcares/metabolismo
[Mh] Termos MeSH secundário: Adulto
Apetite
Regulação do Apetite
Estudos de Coortes
Feminino
Fatores de Crescimento de Fibroblastos/sangue
Fatores de Crescimento de Fibroblastos/metabolismo
Genótipo
Seres Humanos
Masculino
Obesidade/genética
Obesidade/metabolismo
Paladar
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sugars); 0 (fibroblast growth factor 21); 62031-54-3 (Fibroblast Growth Factors)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


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[PMID]:29237125
[Au] Autor:Suh JH; Wang Y; Ho CT
[Ad] Endereço:Food Science and Human Nutrition, Citrus Research and Education Center, University of Florida , 700 Experiment Station Rd, Lake Alfred, Florida 33850, United States.
[Ti] Título:Natural Dietary Products and Their Effects on Appetite Control.
[So] Source:J Agric Food Chem;66(1):36-39, 2018 Jan 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Natural dietary products have been thoroughly studied for their effects of antiadipogenesis to prevent and treat obesity for decades. Nevertheless, in the past few years appetite control for the treatment of obesity has attracted much attention as a new target. Homeostatic control of energy intake involves a complex system that conveys peripheral signals to the central nervous system where multiple signals are integrated and then provide feedback to regulate satiation. This perspective aims at elucidating the neuronal mechanisms of food intake and energy balance as well as providing an alternative pathway of controlling weight using natural dietary products.
[Mh] Termos MeSH primário: Adiposidade/fisiologia
Regulação do Apetite/efeitos dos fármacos
Produtos Biológicos/farmacologia
[Mh] Termos MeSH secundário: Animais
Suplementos Nutricionais
Hormônios/metabolismo
Seres Humanos
Saciação/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biological Products); 0 (Hormones)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05104


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[PMID]:28964791
[Au] Autor:Zhang J; Liu S; Zhang H; Li Y; Wu W; Zhang H
[Ad] Endereço:College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China.
[Ti] Título:Gut satiety hormones cholecystokinin and glucagon-like Peptide-1 amide mediate anorexia induction by trichothecenes T-2 toxin, HT-2 toxin, diacetoxyscirpenol and neosolaniol.
[So] Source:Toxicol Appl Pharmacol;335:49-55, 2017 Nov 15.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The food-borne trichothecene mycotoxins have been documented to cause human and animal food poisoning. Anorexia is a hallmark of the trichothecene mycotoxins-induced adverse effects. Type B trichothecenes have been previously demonstrated to elicit robust anorectic responses, and this response has been directly linked to secretion of the gut satiety hormones cholecystokinin (CCK) and glucagon-like peptide-1 amide (GLP-1). However, less is known about the anorectic effects and underlying mechanisms of the type A trichothecenes, including T-2 toxin (T-2), HT-2 toxin (HT-2), diacetoxyscirpenol (DAS), neosolaniol (NEO). The purpose of this study was to relate type A trichothecenes T-2, HT-2, DAS and NEO-induced anorectic response to changes plasma concentrations of CCK and GLP-1. Following both oral gavage and intraperitoneal (IP) administration of 1mg/kg bw T-2, HT-2, DAS and NEO evoked robust anorectic response and secretion of CCK and GLP-1. Elevations of plasma CCK markedly corresponded to anorexia induction by T-2, HT-2, DAS and NEO. Following oral exposure, plasma CCK was peaked at 6h, 6h, 2h, 2h and lasted up to 24h, 24h, > 6h, > 6h for T-2, HT-2, DAS and NEO, respectively. IP exposed to four toxins all induced elevation of CCK with peak point and duration at 6h and >24h, respectively. In contrast to CCK, GLP-1 was moderately elevated by these toxins. Following both oral and IP exposure, T-2 and HT-2 evoked plasma GLP-1 elevation with peak point and duration at 2h and 6h, respectively. Plasma GLP-1 was peaked at 2h and still increased at 6h for IP and oral administration with DAS and NEO, respectively. In conclusion, CCK plays a contributory role in anorexia induction but GLP-1 might play a lesser role in this response.
[Mh] Termos MeSH primário: Anorexia/prevenção & controle
Regulação do Apetite
Comportamento Animal
Colecistocinina/sangue
Comportamento Alimentar
Peptídeo 1 Semelhante ao Glucagon/sangue
Fragmentos de Peptídeos/sangue
Resposta de Saciedade
Toxina T-2/análogos & derivados
Tricotecenos
[Mh] Termos MeSH secundário: Animais
Anorexia/sangue
Anorexia/induzido quimicamente
Anorexia/psicologia
Modelos Animais de Doenças
Feminino
Camundongos
Transdução de Sinais
Fatores de Tempo
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Peptide Fragments); 0 (Trichothecenes); 107444-51-9 (glucagon-like peptide 1 (7-36)); 65041-92-1 (neosolaniol); 89750-14-1 (Glucagon-Like Peptide 1); 9011-97-6 (Cholecystokinin); I3FL5NM3MO (T-2 Toxin); NC6C26RM46 (HT-2 toxin); UYL28I099N (diacetoxyscirpenol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171002
[St] Status:MEDLINE


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[PMID]:28870812
[Au] Autor:Kang JY; Kim M; Kang Y; Lee W; Ha TK; Seo JH; Son YG; Ha E
[Ad] Endereço:Department of Biochemistry, School of Medicine, Keimyung University, Daegu, Republic of Korea.
[Ti] Título:Thyroidectomy stimulates glucagon-like peptide-1 secretion and attenuates hepatic steatosis in high-fat fed rats.
[So] Source:Biochem Biophys Res Commun;493(1):548-555, 2017 Nov 04.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thyroid hormones (THs) as a therapeutic intervention to treat obesity has been tried but the effect of THs on body weight and the mechanistic details of which are far from clear. This study was designed to determine and elucidate the mechanistic details of metabolic action of THs in high-fat diet (HFD) fed Sprague Dawley (SD) rats. Rats were made surgically hypothyroid (thyroidectomy, Thx). Body weights and food and water intake profoundly decreased in HFD fed thyroidectomized group (HN Thx). Results showed that delayed insulin response, increased total cholesterol, high-density lipoprotein, and low-density lipoprotein in HN Thx. Unexpectedly, however, Thx reduced serum and hepatic triglyceride concentrations. Further studies revealed that Thx dramatically increased circulating GLP-1 as well as increased expressions of GLP-1 in small intestine. Diminished hepatic expressions of lipogenic genes, were observed in HN Thx group. Beta-catenin and glutamine synthetase, a known target of ß-catenin, were up-regulated in the liver of HN Thx group. The expressions of gluconeogenic genes G6P and PCK were reduced in the liver of HN Thx group. The results may suggest that surgery-induced hypothyroidism increases GLP-1, the actions of which may in part be responsible for the reduction in water intake, appetite and hepatic steatosis.
[Mh] Termos MeSH primário: Ingestão de Alimentos
Fígado Gorduroso/metabolismo
Fígado Gorduroso/cirurgia
Peptídeo 1 Semelhante ao Glucagon/secreção
Hormônios Tireóideos/metabolismo
Tireoidectomia
[Mh] Termos MeSH secundário: Animais
Regulação do Apetite
Dieta Hiperlipídica
Gorduras na Dieta
Fígado Gorduroso/diagnóstico
Masculino
Ratos
Ratos Sprague-Dawley
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats); 0 (Thyroid Hormones); 89750-14-1 (Glucagon-Like Peptide 1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE


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[PMID]:28846695
[Au] Autor:Lutter M; Bahl E; Hannah C; Hofammann D; Acevedo S; Cui H; McAdams CJ; Michaelson JJ
[Ad] Endereço:Eating Recovery Center of Dallas, Plano, Texas, United States of America.
[Ti] Título:Novel and ultra-rare damaging variants in neuropeptide signaling are associated with disordered eating behaviors.
[So] Source:PLoS One;12(8):e0181556, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Eating disorders develop through a combination of genetic vulnerability and environmental stress, however the genetic basis of this risk is unknown. METHODS: To understand the genetic basis of this risk, we performed whole exome sequencing on 93 unrelated individuals with eating disorders (38 restricted-eating and 55 binge-eating) to identify novel damaging variants. Candidate genes with an excessive burden of predicted damaging variants were then prioritized based upon an unbiased, data-driven bioinformatic analysis. One top candidate pathway was empirically tested for therapeutic potential in a mouse model of binge-like eating. RESULTS: An excessive burden of novel damaging variants was identified in 186 genes in the restricted-eating group and 245 genes in the binge-eating group. This list is significantly enriched (OR = 4.6, p<0.0001) for genes involved in neuropeptide/neurotrophic pathways implicated in appetite regulation, including neurotensin-, glucagon-like peptide 1- and BDNF-signaling. Administration of the glucagon-like peptide 1 receptor agonist exendin-4 significantly reduced food intake in a mouse model of 'binge-like' eating. CONCLUSIONS: These findings implicate ultra-rare and novel damaging variants in neuropeptide/neurotropic factor signaling pathways in the development of eating disorder behaviors and identify glucagon-like peptide 1-receptor agonists as a potential treatment for binge eating.
[Mh] Termos MeSH primário: Regulação do Apetite/genética
Transtornos da Alimentação e da Ingestão de Alimentos/genética
Redes Reguladoras de Genes
Neuropeptídeos/genética
Transdução de Sinais/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Biologia Computacional
Exoma
Transtornos da Alimentação e da Ingestão de Alimentos/metabolismo
Feminino
Predisposição Genética para Doença
Seres Humanos
Masculino
Meia-Idade
Neuropeptídeos/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neuropeptides)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181556


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[PMID]:28821663
[Au] Autor:Essner RA; Smith AG; Jamnik AA; Ryba AR; Trutner ZD; Carter ME
[Ad] Endereço:Department of Biology, Program in Neuroscience, Williams College, Williamstown, Massachusetts 01267.
[Ti] Título:AgRP Neurons Can Increase Food Intake during Conditions of Appetite Suppression and Inhibit Anorexigenic Parabrachial Neurons.
[So] Source:J Neurosci;37(36):8678-8687, 2017 Sep 06.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To maintain energy homeostasis, orexigenic (appetite-inducing) and anorexigenic (appetite suppressing) brain systems functionally interact to regulate food intake. Within the hypothalamus, neurons that express agouti-related protein (AgRP) sense orexigenic factors and orchestrate an increase in food-seeking behavior. In contrast, calcitonin gene-related peptide (CGRP)-expressing neurons in the parabrachial nucleus (PBN) suppress feeding. PBN CGRP neurons become active in response to anorexigenic hormones released following a meal, including amylin, secreted by the pancreas, and cholecystokinin (CCK), secreted by the small intestine. Additionally, exogenous compounds, such as lithium chloride (LiCl), a salt that creates gastric discomfort, and lipopolysaccharide (LPS), a bacterial cell wall component that induces inflammation, exert appetite-suppressing effects and activate PBN CGRP neurons. The effects of increasing the homeostatic drive to eat on feeding behavior during appetite suppressing conditions are unknown. Here, we show in mice that food deprivation or optogenetic activation of AgRP neurons induces feeding to overcome the appetite suppressing effects of amylin, CCK, and LiCl, but not LPS. AgRP neuron photostimulation can also increase feeding during chemogenetic-mediated stimulation of PBN CGRP neurons. AgRP neuron stimulation reduces Fos expression in PBN CGRP neurons across all conditions. Finally, stimulation of projections from AgRP neurons to the PBN increases feeding following administration of amylin, CCK, and LiCl, but not LPS. These results demonstrate that AgRP neurons are sufficient to increase feeding during noninflammatory-based appetite suppression and to decrease activity in anorexigenic PBN CGRP neurons, thereby increasing food intake during homeostatic need. The motivation to eat depends on the relative balance of activity in distinct brain regions that induce or suppress appetite. An abnormal amount of activity in neurons that induce appetite can cause obesity, whereas an abnormal amount of activity in neurons that suppress appetite can cause malnutrition and a severe reduction in body weight. The purpose of this study was to determine whether a population of neurons known to induce appetite ("AgRP neurons") could induce food intake to overcome appetite-suppression following administration of various appetite-suppressing compounds. We found that stimulating AgRP neurons could overcome various forms of appetite suppression and decrease neural activity in a separate population of appetite-suppressing neurons, providing new insights into how the brain regulates food intake.
[Mh] Termos MeSH primário: Proteína Relacionada com Agouti/metabolismo
Anorexia/fisiopatologia
Regulação do Apetite
Ingestão de Alimentos
Inibição Neural
Neurônios/metabolismo
Núcleos Parabraquiais/fisiopatologia
[Mh] Termos MeSH secundário: Proteína Relacionada com Agouti/genética
Animais
Anorexia/patologia
Hipotálamo/metabolismo
Hipotálamo/patologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Neurônios/patologia
Núcleos Parabraquiais/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Agouti-Related Protein); 0 (Agrp protein, mouse)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170820
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.0798-17.2017



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