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[PMID]:29297078
[Au] Autor:Knip M; Åkerblom HK; Al Taji E; Becker D; Bruining J; Castano L; Danne T; de Beaufort C; Dosch HM; Dupre J; Fraser WD; Howard N; Ilonen J; Konrad D; Kordonouri O; Krischer JP; Lawson ML; Ludvigsson J; Madacsy L; Mahon JL; Ormisson A; Palmer JP; Pozzilli P; Savilahti E; Serrano-Rios M; Songini M; Taback S; Vaarala O; White NH; Virtanen SM; Wasikowa R; Writing Group for the TRIGR Study Group
[Ad] Endereço:University of Helsinki, Helsinki, Finland.
[Ti] Título:Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial.
[So] Source:JAMA;319(1):38-48, 2018 01 02.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Early exposure to complex dietary proteins may increase the risk of type 1 diabetes in children with genetic disease susceptibility. There are no intact proteins in extensively hydrolyzed formulas. Objective: To test the hypothesis that weaning to an extensively hydrolyzed formula decreases the cumulative incidence of type 1 diabetes in young children. Design, Setting, and Participants: An international double-blind randomized clinical trial of 2159 infants with human leukocyte antigen-conferred disease susceptibility and a first-degree relative with type 1 diabetes recruited from May 2002 to January 2007 in 78 study centers in 15 countries; 1081 were randomized to be weaned to the extensively hydrolyzed casein formula and 1078 to a conventional formula. The follow-up of the participants ended on February 28, 2017. Interventions: The participants received either a casein hydrolysate or a conventional adapted cow's milk formula supplemented with 20% of the casein hydrolysate. The minimum duration of study formula exposure was 60 days by 6 to 8 months of age. Main Outcomes and Measures: Primary outcome was type 1 diabetes diagnosed according to World Health Organization criteria. Secondary outcomes included age at diabetes diagnosis and safety (adverse events). Results: Among 2159 newborn infants (1021 female [47.3%]) who were randomized, 1744 (80.8%) completed the trial. The participants were observed for a median of 11.5 years (quartile [Q] 1-Q3, 10.2-12.8). The absolute risk of type 1 diabetes was 8.4% among those randomized to the casein hydrolysate (n = 91) vs 7.6% among those randomized to the conventional formula (n = 82) (difference, 0.8% [95% CI, -1.6% to 3.2%]). The hazard ratio for type 1 diabetes adjusted for human leukocyte antigen risk group, duration of breastfeeding, duration of study formula consumption, sex, and region while treating study center as a random effect was 1.1 (95% CI, 0.8 to 1.5; P = .46). The median age at diagnosis of type 1 diabetes was similar in the 2 groups (6.0 years [Q1-Q3, 3.1-8.9] vs 5.8 years [Q1-Q3, 2.6-9.1]; difference, 0.2 years [95% CI, -0.9 to 1.2]). Upper respiratory infections were the most common adverse event reported (frequency, 0.48 events/year in the hydrolysate group and 0.50 events/year in the control group). Conclusions and Relevance: Among infants at risk for type 1 diabetes, weaning to a hydrolyzed formula compared with a conventional formula did not reduce the cumulative incidence of type 1 diabetes after median follow-up for 11.5 years. These findings do not support a need to revise the dietary recommendations for infants at risk for type 1 diabetes. Trial Registration: clinicaltrials.gov Identifier: NCT00179777.
[Mh] Termos MeSH primário: Caseínas
Diabetes Mellitus Tipo 1/prevenção & controle
Fórmulas Infantis
[Mh] Termos MeSH secundário: Criança
Diabetes Mellitus Tipo 1/epidemiologia
Intervalo Livre de Doença
Método Duplo-Cego
Feminino
Seguimentos
Seres Humanos
Fenômenos Fisiológicos da Nutrição do Lactente
Recém-Nascido
Masculino
Política Nutricional
Risco
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Caseins); 65072-00-6 (casein hydrolysate)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180311
[Lr] Data última revisão:
180311
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180104
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.19826


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[PMID]:29447176
[Au] Autor:Svefors P; Selling KE; Shaheen R; Khan AI; Persson LÅ; Lindholm L
[Ad] Endereço:International Maternal and Child Health, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
[Ti] Título:Cost-effectiveness of prenatal food and micronutrient interventions on under-five mortality and stunting: Analysis of data from the MINIMat randomized trial, Bangladesh.
[So] Source:PLoS One;13(2):e0191260, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Nutrition interventions may have favourable as well as unfavourable effects. The Maternal and Infant Nutrition Interventions in Matlab (MINIMat), with early prenatal food and micronutrient supplementation, reduced infant mortality and were reported to be very cost-effective. However, the multiple micronutrients (MMS) supplement was associated with an increased risk of stunted growth in infancy and early childhood. This unfavourable outcome was not included in the previous cost-effectiveness analysis. The aim of this study is to evaluate whether the MINIMat interventions remain cost-effective in view of both favourable (decreased under-five-years mortality) and unfavourable (increased stunting) outcomes. METHOD: Pregnant women in rural Bangladesh, where food insecurity still is prevalent, were randomized to early (E) or usual (U) invitation to be given food supplementation and daily doses of 30 mg, or 60 mg iron with 400 µg of folic acid, or MMS with 15 micronutrients including 30 mg iron and 400 µg of folic acid. E reduced stunting at 4.5 years compared with U, MMS increased stunting at 4.5 years compared with Fe60, while the combination EMMS reduced infant mortality compared with UFe60. The outcome measure used was disability adjusted life years (DALYs), a measure of overall disease burden that combines years of life lost due to premature mortality (under five-year mortality) and years lived with disability (stunting). Incremental cost effectiveness ratios were calculated using cost data from already published studies. RESULTS: By incrementing UFe60 (standard practice) to EMMS, one DALY could be averted at a cost of US$24. CONCLUSION: When both favourable and unfavourable outcomes were included in the analysis, early prenatal food and multiple micronutrient interventions remained highly cost effective and seem to be meaningful from a public health perspective.
[Mh] Termos MeSH primário: Transtornos do Crescimento/etiologia
Fenômenos Fisiológicos da Nutrição do Lactente/economia
Micronutrientes/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Bangladesh/epidemiologia
Pré-Escolar
Análise Custo-Benefício/métodos
Suplementos Nutricionais
Feminino
Ácido Fólico
Abastecimento de Alimentos
Transtornos do Crescimento/tratamento farmacológico
Transtornos do Crescimento/mortalidade
Seres Humanos
Lactente
Mortalidade Infantil
Fenômenos Fisiológicos da Nutrição do Lactente/efeitos dos fármacos
Fenômenos Fisiológicos da Nutrição do Lactente/fisiologia
Recém-Nascido
Ferro
Masculino
Micronutrientes/administração & dosagem
Política Nutricional
Gravidez
Cuidado Pré-Natal
Fenômenos Fisiológicos da Nutrição Pré-Natal
Oligoelementos
Vitaminas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Micronutrients); 0 (Trace Elements); 0 (Vitamins); 935E97BOY8 (Folic Acid); E1UOL152H7 (Iron)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191260


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[PMID]:29446272
[Au] Autor:Georgieva OV; Konovalova LS; Kon' IY
[Ti] Título:[The system of the quality control and the safety of baby food, the prospects of its development].
[So] Source:Gig Sanit;95(11):1091-5, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:In the article there is considered the substantiation of raise demands to the chemical composition of children's food and indices of their safety, with taking into account the immaturity of metabolic and physiological processes and limitations of "depot" of nutrients in babies. Based on research results of leading experts in the field of children's nutritiology and according to the recommendations of the Codex Alimentarius of the Commission of FAO/WHO, ESPGHAN Committee on Nutrition, the EFSA recommendations and EUDirectives there were specified requirements for the ingredient composition, content of essential components and indices of the nutritional value of substitutes for human milk and functional products for the nutrition of infants of the first year of life. There are shown stages of the development of the Russian system of hygienic requirements for baby food, and the direction of its harmonization with international and European standards, particularly for substitutes for human milk and products of dietary therapeutic and dietary preventive nutrition for babies. There are considered aspects of the introduction ofproducts and weaning food dishes into the food ration of infants. There is presented the classification ofproducts of children's food and the assortment of each group of weaning foods. There is provided the modern legislative framework in the field of the quality and safety for infant nutrition. There was shown the difference between domestic legislation and regulatory framework of the EurAsEC Customs Union of the European countries in the field offood products safety for children older three years. There are presented proposals on the creation of the single regulatory base within the framework of the EurAsEC Customs Union for control the quality and safety of all the baby foods.
[Mh] Termos MeSH primário: Ciências da Nutrição Infantil
Fenômenos Fisiológicos da Nutrição Infantil
Inocuidade dos Alimentos/métodos
Alimentos Infantis/normas
Fenômenos Fisiológicos da Nutrição do Lactente
[Mh] Termos MeSH secundário: Ciências da Nutrição Infantil/métodos
Ciências da Nutrição Infantil/normas
Pré-Escolar
Seres Humanos
Lactente
Fórmulas Infantis/normas
Necessidades Nutricionais/fisiologia
Controle de Qualidade
Federação Russa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE


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[PMID]:29280369
[Au] Autor:Barbarska O; Zielinska M; Pawlus B; Wesolowska A
[Ad] Endereço:Laboratory of Human Milk and Lactation Research, Regional Human Milk Bank in Holy Family Hospital, Department of Neonatology, Medical University of Warsaw, Poland
[Ti] Título:Characteristics of the regional human milk bank in Poland - donors, recipients and nutritional value of human milk
[So] Source:Rocz Panstw Zakl Hig;68(4):395-400, 2017.
[Is] ISSN:0035-7715
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Background: In case of shortage of breast milk despite proper lactation care or the poor state of the mother's health, breast milk from human milk bank is recommended for feeding preterm infants Objective: This study retrospectively evaluated the first year of the operation of the Regional Human Milk Bank Material and methods: Data concerning donors was collected in the human milk bank during the cooperation. The clinical characteristics of the recipients was made on the basis of medical documentation from the Holy Family Hospital in Warsaw, Poland. Analysis of nutritional value was performed with the human milk analyzer (MIRIS AB) Results: In the first year of activity, 45 voluntary donors established cooperation, donating from 650 to 32030 ml of human milk. The content of nutrients in milk provided by donors was variable - protein 0.4-1.5 g / 100 ml, fat 1.1-7.4 g / 100 ml, carbohydrates 6.3-7.9 g / 100 ml. The average length of using donated human milk was 4 days and the average volume of milk for one infant was 282 ml Conclusions: The donor profiles have a significant impact on the milk composition form HMB. The nutritional value can be improved by recruitment donors from mothers that gave birth prematurely and by beginning donation at earlier stages of lactation as soon as lactation is stabilized. In case of shortage of mothers own milk the immediate implementation of donors milk as a short-term support can significantly reduce the food intolerance incidence in the group of prematurely born infants
[Mh] Termos MeSH primário: Bancos de Leite
Leite Humano/química
Valor Nutritivo
[Mh] Termos MeSH secundário: Carboidratos da Dieta/análise
Gorduras na Dieta/análise
Proteínas na Dieta/análise
Feminino
Seres Humanos
Fenômenos Fisiológicos da Nutrição do Lactente
Recém-Nascido
Polônia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Carbohydrates); 0 (Dietary Fats); 0 (Dietary Proteins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE


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[PMID]:28749710
[Au] Autor:Morrell E
[Ad] Endereço:Department of Sociology and Anthropology, Middlebury College , Middlebury, Vermont.
[Ti] Título:First Food Justice: Infant Feeding Disparities and the First Food System.
[So] Source:Breastfeed Med;12(8):489-492, 2017 10.
[Is] ISSN:1556-8342
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Breastfeeding and first foods--including human milk and infant formula--affect us all as individuals and a society of eaters and feeders. They also shape us in part through having significant effects on community health and well-being, workplace strength, and environmental integrity. In addition, we all affect breastfeeding and first foods. Society, the economy, and the environment constrain and enable breastfeeding success, for example, and they often do so differently by race, class, and other social categories. It is important we recognize and address these realities for our own individual interests as well as those we as a citizenry hold in common.
[Mh] Termos MeSH primário: Alimentação Artificial/estatística & dados numéricos
Aleitamento Materno/estatística & dados numéricos
Mães
Política Nutricional
Saúde Pública
[Mh] Termos MeSH secundário: Adulto
Feminino
Conhecimentos, Atitudes e Prática em Saúde
Seres Humanos
Fenômenos Fisiológicos da Nutrição do Lactente
Recém-Nascido
Formulação de Políticas
Meio Social
Justiça Social
Apoio Social
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1089/bfm.2017.0088


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[PMID]:28467097
[Au] Autor:Oiye S; Mwanda W; Mugambi M; Filteau S; Owino V
[Ad] Endereço:1 University of Nairobi Institute of Tropical and Infectious Diseases (UNITID) , Nairobi, Kenya .
[Ti] Título:Exclusive Breastfeeding Is More Common Among HIV-Infected Than HIV-Uninfected Kenyan Mothers at 6 Weeks and 6 Months Postpartum.
[So] Source:Breastfeed Med;12:283-289, 2017 06.
[Is] ISSN:1556-8342
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare breastfeeding practices determined by mothers' own recall versus a stable isotope technique (deuterium oxide dilution) among human immunodeficiency virus (HIV)-infected and HIV-uninfected mothers at 6 weeks and 6 months postpartum. METHODS: Exclusive breastfeeding (EBF) rates were assessed cross-sectionally at 6 weeks and 6 months postpartum among 75 HIV-positive and 68 HIV-negative women attending postnatal care. EBF was derived from maternal 24-hour recall of foods that were fed to the infant and by objective measurement of nonhuman milk-water intake using deuterium oxide (DO) dilution technique. RESULTS: Multivariable logistic analyses were adjusted for infant sex, gravidity, maternal age, marital status, and maternal education. Using recall method, a greater proportion of HIV-infected mothers exclusively breastfed than HIV-uninfected mothers both at 6 weeks postpartum [94.1% versus 76.9%, respectively (adjusted odds ratio [aOR] 7.81; 95% confidence interval [CI] 1.9-31.6, p = 0.004)] and at 6 months postpartum [75% versus 59.7%, respectively (aOR 2.27; 95% CI 1.0-5.3, p = 0.058)]. At 6 weeks postpartum EBF rates from the DO technique were 23.5% and 13.8% for HIV-positive and HIV-negative mothers, respectively (aOR 0.35; 95% CI 0.11-1.04, p = 0.059). At 6 months postpartum, the DO technique determined EBF rates were 43.3% among HIV-positive and 24.2% among HIV-negative mothers, respectively (aOR 2.4; 95% CI 1.0-5.7, p = 0.048). CONCLUSIONS: HIV-infected mothers are more likely to exclusively breastfeed compared with HIV-uninfected mothers. In this resource-poor setting, maternal recall overestimates EBF rates as compared with the deuterium oxide dilution technique. Validating EBF recall data using the objective DO technique is highly recommended for accurate tracking toward global targets on breastfeeding practices.
[Mh] Termos MeSH primário: Aleitamento Materno/estatística & dados numéricos
Infecções por HIV/epidemiologia
Mães
Período Pós-Parto
[Mh] Termos MeSH secundário: Adulto
Fármacos Anti-HIV/uso terapêutico
Estudos Transversais
Óxido de Deutério
Feminino
Infecções por HIV/tratamento farmacológico
Infecções por HIV/transmissão
Comportamentos Relacionados com a Saúde
Inquéritos Epidemiológicos
Seres Humanos
Técnicas de Diluição do Indicador/instrumentação
Lactente
Fenômenos Fisiológicos da Nutrição do Lactente
Recém-Nascido
Quênia
Masculino
Rememoração Mental
Leite Humano/química
Mães/psicologia
Mães/estatística & dados numéricos
Cooperação do Paciente
Gravidez
Autorrelato
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-HIV Agents); J65BV539M3 (Deuterium Oxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1089/bfm.2016.0126


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[PMID]:28461197
[Au] Autor:Abebe Z; Haki GD; Baye K
[Ad] Endereço:Center for Food Science and Nutrition, College of Natural Sciences, POBOX 1176, Addis Ababa University, Addis Ababa, Ethiopia.
[Ti] Título:Child feeding style is associated with food intake and linear growth in rural Ethiopia.
[So] Source:Appetite;116:132-138, 2017 09 01.
[Is] ISSN:1095-8304
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Little is known about mother-child feeding interactions and how this is associated with food intake and linear growth. OBJECTIVE: To characterize mother-child feeding styles and investigate their associations with accepted mouthful and linear growth in west Gojam, rural Ethiopia. SUBJECTS/DESIGN: Two, in-home, meal observations of children aged 12-23 months (n = 100) were video-taped. The number of mouthful accepted was counted and the caregiver/child feeding styles were coded into positive/negative categories of self-feeding, responsive-feeding, active-feeding, social-behavior and distraction. Data on socio-demographic characteristics, child feeding practices, perception about child's overall appetite, and strategies adopted to overcome food refusal were collected through questionnaire-based interviews. Child and mothers' anthropometric measurements were also taken. RESULTS: Stunting was highly prevalent (48%) and the number of mouthful accepted was very low. Offering breastmilk and threatening to harm were the main strategies adopted to overcome food refusal. Although all forms of feeding style were present, active positive feeding style was dominant (90%) and was positively associated with mouthful accepted. Talking with non-feeding partner (64%), and domestic animals (24%) surrounding the feeding place were common distractions of feeding. Feeding was mostly terminated by caregivers (75%), often prematurely. Overall, caregivers of stunted children had poorer complementary- and breast-feeding practices and were less responsive to child's hunger and satiation cues (P < 0.05). Positive responsive feeding behaviors were associated with child's number of mouthful accepted (r = 0.27; P = 0.007) and stunting (r = 0.4; P < 0.001). CONCLUSION: Low complementary food intake in this setting is associated with caregivers' feeding style and stunting. Nutrition interventions that reinforce messages of optimal infant and young child feeding and integrate the promotion of responsive feeding behaviors are needed.
[Mh] Termos MeSH primário: Regulação do Apetite
Comportamento Alimentar
Transtornos de Alimentação na Infância/etiologia
Transtornos do Crescimento/etiologia
Fenômenos Fisiológicos da Nutrição do Lactente
Desnutrição/etiologia
Saúde da População Rural
[Mh] Termos MeSH secundário: Regulação do Apetite/etnologia
Desenvolvimento Infantil
Educação Infantil/etnologia
Estudos Transversais
Países em Desenvolvimento
Ingestão de Energia/etnologia
Etiópia
Comportamento Alimentar/etnologia
Transtornos de Alimentação na Infância/etnologia
Transtornos de Alimentação na Infância/fisiopatologia
Transtornos de Alimentação na Infância/prevenção & controle
Feminino
Transtornos do Crescimento/epidemiologia
Transtornos do Crescimento/etnologia
Transtornos do Crescimento/prevenção & controle
Seres Humanos
Lactente
Almoço/etnologia
Masculino
Desnutrição/etnologia
Desnutrição/fisiopatologia
Desnutrição/prevenção & controle
Mães
Prevalência
Saúde da População Rural/etnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:29352304
[Au] Autor:Wang X; Luo R; Liu C; Zhang L; Yue A; Medina A; Rozelle S
[Ad] Endereço:Education Global Practices (East and South Africa), the World Bank Group, NW, Washington DC, United States of America.
[Ti] Título:Using daily text messages to improve adherence to infant micronutrient powder (MNP) packets in rural western China: A cluster-randomized controlled trial.
[So] Source:PLoS One;13(1):e0191549, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the effectiveness of daily text messages as a means to improve caregivers' adherence to infant micronutrient powder (MNP) in rural Shaanxi Province of China. METHODOLOGY: 638 infants aged 6-11 months in 234 villages were involved in a cluster-randomized controlled trial (RCT). All caregivers were given free infant MNP packets at baseline in April 2013 and the follow-up survey was in July 2013. We randomly assigned 318 infants in 117 villages to treatment group (receiving daily text message) and 320 infants in the other 117 villages as control group. RESULTS: On average, daily text messages increased the number of MNP packets fed (marginal effect = 4.63; 95% confidence interval (CI) = 0.16, 9.10). The text message is more likely to increase the consumption of MNP packets if the primary caregiver was the mother (marginal effect = 12.19; 95% CI = 0.69, 23.68). Receiving the text message appears to significantly increase the likelihood of full adherence when the primary caregiver can either check (odds ratio = 2.93; 95% CI = 1.34, 6.40) or knows how to send (odds ratio = 3.26; 95% CI = 1.53, 6.97) text messages. CONCLUSION: Daily text messages improved the consumption of infant MNP packets. However, the impact was not large enough to increase the probability of caregivers being fully adherent to the feeding instruction, which is to feed 5-7 packets per week as recommended. In addition, when the mother is the caregiver and when the caregiver can check or knows how to send text messages there is greater adherence by the primary caregivers. TRIAL REGISTRATION: http://www.isrctn.com/ISRCTN44149146.
[Mh] Termos MeSH primário: Adesão à Medicação
Micronutrientes/administração & dosagem
Mensagem de Texto
[Mh] Termos MeSH secundário: Cuidadores
China
Feminino
Seres Humanos
Lactente
Alimentos Infantis
Transtornos da Nutrição do Lactente/prevenção & controle
Fenômenos Fisiológicos da Nutrição do Lactente
Masculino
Adesão à Medicação/estatística & dados numéricos
Razão de Chances
Pós
População Rural
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Micronutrients); 0 (Powders)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180121
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191549


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[PMID]:29363924
[Au] Autor:Lukoyanova OL; Borovik TE
[Ti] Título:[Nutritional epigenetics and epigenetic effects of human breast milk].
[So] Source:Vopr Pitan;84(5):4-15, 2015.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The article provides an overview of the current literature on nutritional epigenetics. There are currently actively studied hypothesis that nutrition especially in early life or in critical periods of the development, may have a role in modulating gene expression, and, therefore, have later effects on health in adults. Nutritional epigenetics concerns knowledge about the possible effects of nutrients on gene expression. Human breast milk is well-known for its ability in preventing necrotizing enterocolitis, infectious diseases, and also non-communicable diseases, such as obesity and related disorders. This paper discusses about presumed epigenetic effects of human breast milk and some its components. While evidence suggests that a direct relationship may exist of some components of human breast milk with epigenetic changes, the mechanisms involved are stillunclear.
[Mh] Termos MeSH primário: Aleitamento Materno
Epigênese Genética/fisiologia
Fenômenos Fisiológicos da Nutrição do Lactente
Leite Humano/metabolismo
Valor Nutritivo
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Recém-Nascido
Doenças do Recém-Nascido/genética
Doenças do Recém-Nascido/metabolismo
Doenças do Recém-Nascido/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE


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[PMID]:28464867
[Au] Autor:Billah SM; Ferdous TE; Karim MA; Dibley MJ; Raihana S; Moinuddin M; Choudhury N; Ahmed T; Hoque DME; Menon P; Arifeen SE
[Ad] Endereço:Maternal and Child Health Division, icddr,b, 68 Shahid Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh. billah@icddrb.org.
[Ti] Título:A community-based cluster randomised controlled trial to evaluate the effectiveness of different bundles of nutrition-specific interventions in improving mean length-for-age z score among children at 24 months of age in rural Bangladesh: study protocol.
[So] Source:BMC Public Health;17(1):375, 2017 05 02.
[Is] ISSN:1471-2458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Prevalence of stunting among under-five children in Bangladesh is 36%, varying with geographic and socio-economic characteristics. Previously, research groups statistically modelled the effect of 10 individual nutrition-specific interventions targeting the critical first 1000 days of life from conception, on lives saved and costs incurred in countries with the highest burden of stunted children. However, primary research on the combined effects of these interventions is limited. Our study directly addresses this gap by examining the effect of combinations of 5 preventive interventions on length-for-age z-scores (LAZ) among 2-years old children. METHODS: This community-based cluster randomised trial (c-RCT) compares 4 intervention combinations against one comparison arm. Intervention combinations are: 1) Behaviour change communication (BCC) on maternal nutrition during pregnancy, exclusive breastfeeding, and complementary feeding, along with prenatal nutritional supplement (PNS) and complementary food supplement (CFS); 2) BCC with PNS; 3) BCC with CFS; and 4) BCC alone. The comparison arm receives only routine health and nutrition services. From a rural district, 125 clusters were selected and randomly assigned to any one of the five study arms by block randomisation. A bespoke automated tab-based system was developed linking data collection, intervention delivery and project supervision. Total sample size is 1500 pregnant women, with minimum 1050 resultant children expected to be retained, powered to detect a difference of at least 0.4 in the mean LAZ score of children at 24 months, the main outcome variable, between the comparison arm and each intervention arm. Length and other anthropometric measurements, nutritional intake and other relevant data on mother and children are being collected during enrolment, twice during pregnancy, postpartum monthly till 6 months, and every third month thereafter till 24 months. DISCUSSION: This c-RCT explores the effectiveness of bundles of preventive nutrition intervention approaches addressing the critical window of opportunity to mitigate childhood stunting. The results will provide robust evidence as to which bundle(s) can have significant effect on linear growth of children. Our study also will have policy-level implications for prioritising intervention(s) tackling stunting. TRIAL REGISTRATION: The study was retrospectively registered on May 2, 2016 and is available online at ClinicalTrials.gov (ID: NCT02768181 ).
[Mh] Termos MeSH primário: Suplementos Nutricionais
Transtornos do Crescimento/prevenção & controle
Comportamentos Relacionados com a Saúde
Mães
Pacotes de Assistência ao Paciente
[Mh] Termos MeSH secundário: Antropometria
Bangladesh
Aleitamento Materno
Desenvolvimento Infantil
Pré-Escolar
Feminino
Seres Humanos
Lactente
Fenômenos Fisiológicos da Nutrição do Lactente
Fenômenos Fisiológicos da Nutrição Materna
Estado Nutricional
Gravidez
Projetos de Pesquisa
População Rural
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180121
[Lr] Data última revisão:
180121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1186/s12889-017-4281-0



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