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[PMID]:29422103
[Au] Autor:Thomsson O; Magnusson U; Bergqvist AS; Eliasson-Selling L; Sjunnesson YCB
[Ad] Endereço:Division of Reproduction, Department of Clinical Sciences, Swedish University of Agricultural Sciences, SLU, P.O. Box 7054, 750 07, Uppsala, Sweden.
[Ti] Título:Sow performance in multi-suckling pens with different management routines.
[So] Source:Acta Vet Scand;60(1):10, 2018 Feb 08.
[Is] ISSN:1751-0147
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Production systems with group housing of sows during a part of the lactation are used in certified organic production and can increase the occurrence of lactational estrus thus making batch-wise breeding difficult. The aim of this study was to investigate the occurrence of lactational estrus and time at return to estrus after weaning by following the performance of the sow (change in body weight, back fat and litter size) in three different management routines. The sows and their litters were moved from individual to multi-suckling pen at one (W1; n = 14), two (W2; n = 13), or 3 weeks (W3; n = 16) post farrowing. All sows had a total lactation of 6 weeks. Ovulation was monitored by analysis of fecal progesterone metabolites. Only one sow (W3) ovulated during lactation. Sows in the W2 and W3 groups had a shorter weaning-to-standing estrus interval than W1-sows (2.6 ± 0.3; 2.7 ± 0.2 and 4.0 ± 0.3 days respectively, P < 0.001). The W1-sows and piglets might have kept their nursing bond more intact all through the group housing since the piglets were completely dependent on the nursing at the time of their move to the group pen, thereby staying in lactational anestrus and retaining standard weaning-estrous interval. There was no difference in litter size at grouping or at weaning between management routines and parities. Third and later parity sows had significantly thicker back fat at farrowing and at weaning than 1st and 2nd parity sows (P < 0.05). In conclusion, the occurrence of lactational estrus can be low in a multi-suckling pen and the interval between farrowing and move to a multi-suckling pen can affect the weaning to estrus interval. The short weaning-to-standing estrus interval seen in W2 and W3 suggests that estrus detection should start immediately post weaning for sows kept in multi-suckling pens.
[Mh] Termos MeSH primário: Criação de Animais Domésticos/métodos
Estro/fisiologia
Lactação/fisiologia
Suínos/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Abrigo para Animais/normas
Tamanho da Ninhada de Vivíparos
Desmame
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE
[do] DOI:10.1186/s13028-018-0364-x


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[PMID]:29254298
[Au] Autor:Khawar MB; Sheikh N
[Ad] Endereço:Cell and Molecular Biology Laboratory, Department of Zoology, University of the Punjab, Lahore-Pakistan.
[Ti] Título:Alterations in transaminase activity and serum level of leptin and hepcidin induced by high fat diet in albino rats.
[So] Source:J Biol Regul Homeost Agents;31(4):951-956, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Obesity is a commonly growing life-threatening problem of the modern world. The present study was aimed to assess alterations in transaminase levels as well as leptin and hepcidin levels of sera through ELISA after high fat diet consumption for sixteen weeks by albino rats (n=5). Three groups were established: experimental groups 1 and 2 and a control group. Group 1 was fed on a high fat diet having a composition of 33% rat chow +33% sucrose +33% milk powder. Similarly, group 2 was fed with another high fat diet with a mixture of rat chow and milk powder ad libitum. The control group was fed on normal rat chow and water ad libitum. After sixteen weeks, the rats were euthanized and blood was collected for serum separation. Serum levels of alanine aminotransferase showed a positive significant increase (P=0.0325) while a significant negative change (P=0.0006) was noted in aspartate aminotransferase levels in both the experimental groups compared to the control group. Serum leptin levels were found to be increased up to 10.06-fold in Group 1 and 6.11-fold in Group 2 when compared to controls. On the other hand, serum hepcidin levels showed up to 1-fold and 2.59-fold changes in Group 1 and Group 2, respectively, compared to controls. Taken together, from these results it can be concluded that a high fat diet not only disturbs normal metabolism, but it also leads to liver inflammation which is obvious by the changes in transaminase activity as well as leptin and hepcidin levels.
[Mh] Termos MeSH primário: Alanina Transaminase/sangue
Aspartato Aminotransferases/sangue
Gorduras na Dieta/efeitos adversos
Hepcidinas/sangue
Leptina/sangue
Obesidade/genética
[Mh] Termos MeSH secundário: Alanina Transaminase/genética
Animais
Aspartato Aminotransferases/genética
Dieta Hiperlipídica
Expressão Gênica
Hepcidinas/genética
Leptina/genética
Fígado/metabolismo
Fígado/patologia
Masculino
Obesidade/sangue
Obesidade/etiologia
Obesidade/patologia
Ratos
Desmame
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats); 0 (Hamp protein, rat); 0 (Hepcidins); 0 (Leptin); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


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[PMID]:29230876
[Au] Autor:Casellas J
[Ad] Endereço:Grup de Recerca en Millora Genètica Molecular Veterinària, Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona, Bellaterra, Spain.
[Ti] Título:On individual-specific prediction of hidden inbreeding depression load.
[So] Source:J Anim Breed Genet;135(1):37-44, 2018 Feb.
[Is] ISSN:1439-0388
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Inbreeding depression is caused by increased homozygosity in the genome and merges two genetic mechanisms, a higher impact from recessive mutations and the waste of overdominance contributions. It is of major concern for the conservation of endangered populations of plants and animals, as major abnormalities are more frequent in inbred families than in outcrosses. Nevertheless, we lack appropriate analytical methods to estimate the hidden inbreeding depression load (IDL) in the genome of each individual. Here, a new mixed linear model approach has been developed to account for the inbreeding depression-related background of each individual in the pedigree. Within this context, inbred descendants contributed relevant information to predict the IDL contained in the genome of a given ancestor; moreover, known relationships spread these predictions to the remaining individuals in the pedigree, even if not contributing inbred offspring. Results obtained from the analysis of weaning weight in the MARET rabbit population demonstrated that the genetic background of inbreeding depression distributed heterogeneously across individuals and inherited generation by generation. Moreover, this approach was clearly preferred in terms of model fit and complexity when compared with classical approaches to inbreeding depression. This methodology must be viewed as a new tool for a better understanding of inbreeding in domestic and wild populations.
[Mh] Termos MeSH primário: Genômica
Depressão por Endogamia
[Mh] Termos MeSH secundário: Animais
Peso Corporal/genética
Feminino
Modelos Lineares
Masculino
Linhagem
Coelhos
Desmame
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1111/jbg.12308


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[PMID]:28455617
[Au] Autor:Peng Y; Yu K; Mu C; Hang S; Che L; Zhu W
[Ad] Endereço:Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, Laboratory of Gastrointestinal Microbiology, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, 210095, People's Republic of China.
[Ti] Título:Progressive response of large intestinal bacterial community and fermentation to the stepwise decrease of dietary crude protein level in growing pigs.
[So] Source:Appl Microbiol Biotechnol;101(13):5415-5426, 2017 Jul.
[Is] ISSN:1432-0614
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The study aimed to determine the effects of reduction of dietary crude protein (CP) level with balanced essential amino acids (EAA) on intestinal bacteria and their metabolites of growing pigs. Forty pigs (initial BW 13.50 ± 0.50 kg, 45 ± 2 days of age) were randomly assigned to four dietary treatments containing CP levels at 20.00% (normal crude protein, NP); 17.16% (medium crude protein, MP); 15.30% (low crude protein, LP); and 13.90% (extremely low crude protein, ELP), respectively. Crystalline AAs were added to meet the EAA requirement of pigs. After 4-week feeding, eight pigs per treatment (n = 8) were randomly selected and slaughtered for sampling of ileal, cecal, and colonic digesta and mucosa. Pigs with moderately reduced CP level had increased bacterial diversity, with the Shannon diversity indices for the colon digesta in the LP group and mucosa in the MP and LP groups significantly (P < 0.05) higher than those in the NP and ELP groups. As the CP level reduces, the Bifidobacterium population were linearly decreased (P < 0.05) both in ileum, cecum, and colon, and the ELP group had the lowest Bifidobacterium population in the cecum and colon, with its value significantly lower than NP and MP groups (P < 0.05). However, the ELP group had the highest population of Escherichia coli in the colon, with its value significantly higher than the LP group (P < 0.05). For bacterial metabolites, as CP level decreased, total short-chain fatty acid (T-SCFA), acetate, and butyrate were linearly increased (linear, P < 0.05) in the ileum, while all SCFAs except formate in the cecum and T-SCFA and acetate in the colon, were linearly decreased (P < 0.05). Reducing CP level led to a linear decrease of microbial crude protein (MCP) in the ileum (P < 0.05) and ammonia in all intestine segments (P < 0.05). The spermidine in cecum and total amines, cadaverine, methylamine, and spermidine in colon were shown a quadratic change (P < 0.05) as dietary CP decreases, with the highest concentration in LP group. These findings suggest that moderate reduction of dietary CP level may benefit large intestinal bacterial community and its fermentation, which was negatively affected by extremely low CP diet.
[Mh] Termos MeSH primário: Aminoácidos Essenciais/administração & dosagem
Ração Animal
Ceco/microbiologia
Colo/microbiologia
Proteínas na Dieta/administração & dosagem
Fermentação
Consórcios Microbianos/fisiologia
[Mh] Termos MeSH secundário: Aminas/análise
Aminoácidos Essenciais/análise
Ração Animal/análise
Animais
Bifidobacterium/isolamento & purificação
Proteínas na Dieta/análise
Proteínas na Dieta/química
Digestão
Escherichia coli/isolamento & purificação
Ácidos Graxos Voláteis/metabolismo
Íleo/microbiologia
Distribuição Aleatória
Espermidina/análise
Suínos
Desmame
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amines); 0 (Amino Acids, Essential); 0 (Dietary Proteins); 0 (Fatty Acids, Volatile); U87FK77H25 (Spermidine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1007/s00253-017-8285-6


  5 / 9633 MEDLINE  
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[PMID]:29190757
[Au] Autor:Pinsky M; Rauch M; Abbas A; Sharabi-Nov A; Tamir S; Gutman R
[Ad] Endereço:Unit of Integrative Physiology (LIP), Laboratory of Human Health and Nutrition Sciences, MIGAL-Galilee Research Institute, Kiryat Shmona, Israel.
[Ti] Título:Long-lived weight-reduced αMUPA mice show higher and longer maternal-dependent postnatal leptin surge.
[So] Source:PLoS One;12(11):e0188658, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We investigated whether long-lived weight-reduced αMUPA mice differ from their wild types in postnatal body composition and leptin level, and whether these differences are affected by maternal-borne factors. Newborn αMUPA and wild type mice had similar body weight and composition up to the third postnatal week, after which αMUPA mice maintained lower body weight due to lower fat-free mass. Both strains showed a surge in leptin levels at the second postnatal week, initiating earlier in αMUPA mice, rising higher and lasting longer than in the wild types, mainly in females. Leptin level in dams' serum and breast milk, and in their pup's stomach content were also higher in αMUPA than in the WT during the surge peak. Leptin surge preceded the strain divergence in body weight, and was associated with an age-dependent decrease in the leptin:fat mass ratio-suggesting that postnatal sex and strain differences in leptin ontogeny are strongly influenced by processes independent of fat mass, such as production and secretion, and possibly outside fat tissues. Dam removal elevated corticosterone level in female pups from both strains similarly, yet mitigated the leptin surge only in αMUPA-eliminating the strain differences in leptin levels. Overall, our results indicate that αMUPA's postnatal leptin surge is more pronounced than in the wild type, more sensitive to maternal deprivation, less related to pup's total adiposity, and is associated with a lower post-weaning fat-free mass. These strain-related postnatal differences may be related to αMUPA's higher milk-borne leptin levels. Thus, our results support the use of αMUPA mice in future studies aimed to explore the relationship between maternal (i.e. milk-borne) factors, postnatal leptin levels, and post-weaning body composition and energy homeostasis.
[Mh] Termos MeSH primário: Leptina/metabolismo
[Mh] Termos MeSH secundário: Animais
Composição Corporal
Peso Corporal
Feminino
Leptina/sangue
Camundongos
Leite/metabolismo
Gravidez
Desmame
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Leptin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188658


  6 / 9633 MEDLINE  
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[PMID]:29211391
[Au] Autor:McGuire E
[Ti] Título:Feelings of failure: Early weaning.
[So] Source:Breastfeed Rev;24(2):21-6, 2016 Jul.
[Is] ISSN:0729-2759
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:... it was horrible - a difficult, painful and agonizing process. ... Nothing I tried made it anything but torture. Finally, my son got a mouthful of blood, and I gave up. I felt like a failure. It added to my depression, made me question my ability to mother, and caused my infant to lose too much weight. (The American Dietetic Association's) position paper has no loopholes for us 'failures', no compassion for those of us too poor to rent an electric pump ... Could you please let us off the hook? (Saban, 2002, p. 24) I can't say what a devastating experience failing to breastfeed Bianca was for me. I was left feeling like I'd failed her as a mother, and even as a woman. I found it difficult to talk about, and was loath to bottle feed Bianca in public.
[Mh] Termos MeSH primário: Aleitamento Materno/psicologia
Depressão Pós-Parto/psicologia
Mães/psicologia
Desmame
[Mh] Termos MeSH secundário: Adulto
Austrália
Feminino
Seres Humanos
Lactente
Recém-Nascido
Comportamento Materno/psicologia
Mamilos
Percepção Social
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:K
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  7 / 9633 MEDLINE  
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[PMID]:27779623
[Au] Autor:Rincón-Cortés M; Sullivan RM
[Ad] Endereço:Department of Child and Adolescent Psychiatry, Child Study Center, New York University Langone Medical Center, New York, NY, USA.
[Ti] Título:Emergence of social behavior deficit, blunted corticolimbic activity and adult depression-like behavior in a rodent model of maternal maltreatment.
[So] Source:Transl Psychiatry;6(10):e930, 2016 10 25.
[Is] ISSN:2158-3188
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Disrupted social behavior is a core symptom of multiple psychiatric and neurodevelopmental disorders. Many of these disorders are exacerbated by adverse infant experiences, including maltreatment and abuse, which negatively affect amygdala development. Although a link between impaired social behavior, abnormal amygdala function and depressive-like behavior following early adversity has been demonstrated in humans and animal models, the developmental emergence of maltreatment-related social deficits and associated amygdala neural activity are unknown. We used a naturalistic rodent model of maternal maltreatment during a sensitive period, postnatal days 8-12 (PN8-12), which produces social behavior deficits that precede adolescent depressive-like behavior and amygdala dysfunction, to examine social behavior in infancy, periweaning and adolescence. Neural activity in response to the social behavior test was assessed via c-Fos immunohistochemistry at these ages. A separate group of animals was tested for adult depressive-like behavior in the forced swim test. Maltreatment spared infant (PN16-18) social behavior but disrupted periweaning (PN20-22) and adolescent (PN42-48) social behavior. Maltreated rats exhibited blunted neural activation in the amygdala and other areas implicated in social functioning, including the medial prefrontal cortex and nucleus accumbens, at these ages and increased adult depressive-like behavior. These findings may suggest corticolimbic involvement in the emergence of maltreatment-induced social deficits that are linked to adult depressive-like behavior, thereby highlighting potential targets for therapeutic intervention. Understanding how infant experiences influence social behavior and age-specific expression across development may provide insights into basic neural mechanisms of social behaviors and disease-relevant social dysfunction exacerbated by early-life stress.
[Mh] Termos MeSH primário: Tonsila do Cerebelo/fisiopatologia
Córtex Cerebral/fisiopatologia
Transtorno Depressivo/fisiopatologia
Modelos Animais de Doenças
Acontecimentos que Mudam a Vida
Transtornos do Comportamento Social/fisiopatologia
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Feminino
Expressão Gênica/genética
Masculino
Proteínas Proto-Oncogênicas c-fos/genética
Ratos
Ratos Long-Evans
Desmame
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Proto-Oncogene Proteins c-fos)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1038/tp.2016.205


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[PMID]:28964809
[Au] Autor:Wang W; Sun Y; Guo Y; Cai P; Li Y; Liu J; Cai G; Kiyoshi A; Zhang W
[Ad] Endereço:Department of Health Inspection and Quarantine, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China; Fujian Province Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China. Electronic address: wangwenxiang@fjmu.edu.cn
[Ti] Título:Continuous soy isoflavones exposure from weaning to maturity induces downregulation of ovarian steroidogenic factor 1 gene expression and corresponding changes in DNA methylation pattern.
[So] Source:Toxicol Lett;281:175-183, 2017 Nov 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Female Wistar rats were treated with orally administered soy isoflavones at concentrations of 0, 25, 50, or 100mg/kg body weight from weaning until sexual maturity (3 mo.), and ovarian steroidogenesis was evaluated. After soy isoflavones were administered, a significant (P<0.05) decrease (44%) in the serum estrodial levels of the high-dose (HD) group were observed. Cultured granulosa cells from the middle- (MD) and HD groups showed significantly (P<0.05) reduced (31%, 45%, respectively) in vitro estradiol secretion, and those from the HD group showed significantly (P<0.05) reduced progesterone (25%) secretion. Compared with the control group, the mRNA expression of the steroidogenic acute regulatory protein (Star), cytochromeP450 cholesterol side chain cleavage (Cyp11a1 and Cyp19a1), and hydroxysteroid dehydrogenase 3b (Hsd3b) genes also decreased. Real-time quantitative PCR and Western blotting revealed a significant (P<0.05) decrease in key transcription factor steroidogenic factor-1 (SF-1) expression in the HD group. The detection of DNA methylation using bisulfitesequencing PCR (BSP) suggested a significantly (P<0.05) increased total methylation rate in the proximal SF-1 promoter in the HD group. Further studies showed that treatment with soy isoflavones can significantly (P<0.05) increase the mRNA expression of DNA methyltransferase (DNMT) 1 and DNMT3a. This study proved that soy isoflavone administration from weaning until sexual maturity could inhibit ovarian steroidogenesis, suggesting that SF-1 might play an important role in this effect. In addition, DNA methylation might play a role in the downregulation of SF-1 gene expression induced by soy isoflavones.
[Mh] Termos MeSH primário: Metilação de DNA/efeitos dos fármacos
Isoflavonas/farmacologia
Fator Esteroidogênico 1/metabolismo
Desmame
[Mh] Termos MeSH secundário: Animais
Aromatase/genética
Aromatase/metabolismo
Enzima de Clivagem da Cadeia Lateral do Colesterol/genética
Enzima de Clivagem da Cadeia Lateral do Colesterol/metabolismo
DNA (Citosina-5-)-Metiltransferase 1
DNA (Citosina-5-)-Metiltransferases/genética
DNA (Citosina-5-)-Metiltransferases/metabolismo
Relação Dose-Resposta a Droga
Regulação para Baixo
Estradiol/sangue
Feminino
Ovário/efeitos dos fármacos
Ovário/metabolismo
Fosfoproteínas/genética
Fosfoproteínas/metabolismo
Regiões Promotoras Genéticas
Ratos
Ratos Wistar
Feijão de Soja/química
Fator Esteroidogênico 1/genética
Fatores de Transcrição/genética
Fatores de Transcrição/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Isoflavones); 0 (Phosphoproteins); 0 (Steroidogenic Factor 1); 0 (Transcription Factors); 0 (steroidogenic acute regulatory protein); 0 (steroidogenic factor 1, rat); 4TI98Z838E (Estradiol); EC 1.14.14.1 (Aromatase); EC 1.14.15.6 (Cholesterol Side-Chain Cleavage Enzyme); EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferase 1); EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferases); EC 2.1.1.37 (DNA methyltransferase 3A)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171002
[St] Status:MEDLINE


  9 / 9633 MEDLINE  
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[PMID]:28957383
[Au] Autor:Vargas VE; Gurung S; Grant B; Hyatt K; Singleton K; Myers SM; Saunders D; Njoku C; Towner R; Myers DA
[Ad] Endereço:Departments of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America.
[Ti] Título:Gestational hypoxia disrupts the neonatal leptin surge and programs hyperphagia and obesity in male offspring in the Sprague-Dawley rat.
[So] Source:PLoS One;12(9):e0185272, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The effect of gestational hypoxia on the neonatal leptin surge, development of hypothalamic arcuate nuclei (ARH) projections and appetite that could contribute to the programming of offspring obesity is lacking. We examined the effect of 12% O2 from gestational days 15-19 in the Sprague-Dawley rat on post-weaning appetite, fat deposition by MRI, adipose tissue cytokine expression, the neonatal leptin surge, ARH response to exogenous leptin, and αMSH projections to the paraventricular nucleus (PVN) in response to a high fat (HFD) or control diet (CD) in male offspring. Normoxia (NMX) and Hypoxia (HPX) offspring exhibited increased food intake when fed a HFD from 5-8 weeks post-birth; HPX offspring on the CD had increased food intake from weeks 5-7 vs. NMX offspring on a CD. HPX offspring on a HFD remained hyperphagic through 23 weeks. Body weight were the same between offspring from HPX vs. NMX dams from 4-12 weeks of age fed a CD or HFD. By 14-23 weeks of age, HPX offspring fed the CD or HFD as well as male NMX offspring fed the HFD were heavier vs. NMX offspring fed the CD. HPX offspring fed a CD exhibited increased abdominal adiposity (MRI) that was amplified by a HFD. HPX offspring fed a HFD exhibited the highest abdominal fat cytokine expression. HPX male offspring had higher plasma leptin from postnatal day (PN) 6 through 14 vs. NMX pups. HPX offspring exhibited increased basal c-Fos labeled cells in the ARH vs. NMX pups on PN16. Leptin increased c-Fos staining in the ARH in NMX but not HPX offspring at PN16. HPX offspring had fewer αMSH fibers in the PVN vs. NMX offspring on PN16. In conclusion, gestational hypoxia impacts the developing ARH resulting in hyperphagia contributing to adult obesity on a control diet and exacerbated by a HFD.
[Mh] Termos MeSH primário: Hiperfagia/sangue
Hiperfagia/complicações
Hipóxia/sangue
Hipóxia/complicações
Leptina/sangue
Obesidade/sangue
Obesidade/complicações
[Mh] Termos MeSH secundário: Tecido Adiposo/metabolismo
Animais
Animais Recém-Nascidos
Ansiedade/sangue
Ansiedade/complicações
Núcleo Arqueado do Hipotálamo/metabolismo
Comportamento Animal
Dieta
Medo
Comportamento Alimentar
Feminino
Peso Fetal
Interleucina-1beta/genética
Interleucina-1beta/metabolismo
Interleucina-6/genética
Interleucina-6/metabolismo
Imagem por Ressonância Magnética
Masculino
Fenômenos Fisiológicos da Nutrição Materna
Aprendizagem em Labirinto
Atividade Motora
Gravidez
Ratos Sprague-Dawley
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/metabolismo
Água
Desmame
alfa-MSH/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-1beta); 0 (Interleukin-6); 0 (Leptin); 0 (Tumor Necrosis Factor-alpha); 059QF0KO0R (Water); 581-05-5 (alpha-MSH)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185272


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[PMID]:28835389
[Au] Autor:Ying Z; Zhang H; Su W; Zhou L; Wang F; Li Y; Zhang L; Wang T
[Ad] Endereço:College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, People's Republic of China.
[Ti] Título:Dietary Methionine Restriction Alleviates Hyperglycemia in Pigs with Intrauterine Growth Restriction by Enhancing Hepatic Protein Kinase B Signaling and Glycogen Synthesis.
[So] Source:J Nutr;147(10):1892-1899, 2017 Oct.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Individuals with intrauterine growth restriction (IUGR) are prone to developing type 2 diabetes mellitus (T2DM). Dietary methionine restriction (MR) improves insulin sensitivity and glucose homeostasis in individuals with normal birth weight (NBW). This study investigated the effects of MR on plasma glucose concentration and hepatic and muscle glucose metabolism in pigs with IUGR. Thirty female NBW and 60 same-sex spontaneous IUGR piglets (Landrace × Yorkshire) were selected. After weaning (day 21), the piglets were fed diets with adequate methionine (NBW-CON and IUGR-CON) or 30% less methionine (IUGR-MR) ( = 6). At day 180, 1 pig with a body weight near the mean of each replication was selected for biochemical analysis. The IUGR-CON group showed 41.6%, 68.6%, and 67.1% higher plasma glucose concentration, hepatic phosphoenolpyruvate carboxykinase activity, and glucose-6-phosphatase activity, respectively, than the NBW-CON group ( < 0.05). Muscle glycogen content and glycogen synthase activity were 36.9% and 38.8% lower, respectively, in the IUGR-CON than the NBW-CON group ( < 0.05), respectively, and there was decreased hepatic and muscle protein kinase B phosphorylation in the IUGR-CON group ( < 0.05). Compared with the IUGR-CON pigs, the IUGR-MR pigs had 28.7% lower plasma glucose concentrations ( < 0.05), which were similar to those of the NBW-CON pigs ( ≥ 0.05). The hepatic glycogen content and glycogen synthase activity of the IUGR-MR pigs were 62.9% and 50.8% higher than those of the IUGR-CON pigs ( < 0.05) and 53.5% and 84.3% higher than the NBW-CON pigs ( < 0.05), respectively. The IUGR-MR pigs' hepatic and muscle protein kinase B phosphorylation was higher than that of the IUGR-CON pigs ( < 0.05) and similar to that of the NBW-CON pigs ( ≥ 0.05). MR attenuates hyperglycemia in IUGR pigs by enhancing hepatic protein kinase B signaling and glycogen synthesis, implying a potential nutritional strategy to prevent type 2 diabetes mellitus in IUGR offspring.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/metabolismo
Retardo do Crescimento Fetal
Glicogênio/biossíntese
Hiperglicemia/dietoterapia
Fígado/metabolismo
Metionina/administração & dosagem
Proteínas Proto-Oncogênicas c-akt/metabolismo
[Mh] Termos MeSH secundário: Ração Animal
Animais
Animais Recém-Nascidos
Peso ao Nascer
Glicemia/metabolismo
Diabetes Mellitus Tipo 2/prevenção & controle
Dieta
Feminino
Glucose-6-Fosfatase/metabolismo
Glicogênio/metabolismo
Hiperglicemia/metabolismo
Resistência à Insulina
Masculino
Metionina/metabolismo
Metionina/farmacologia
Músculos/metabolismo
Fosfoenolpiruvato Carboxiquinase (GTP)/metabolismo
Fosforilação
Transdução de Sinais
Suínos
Desmame
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 9005-79-2 (Glycogen); AE28F7PNPL (Methionine); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 3.1.3.9 (Glucose-6-Phosphatase); EC 4.1.1.32 (Phosphoenolpyruvate Carboxykinase (GTP))
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.253427



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