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[PMID]: | 27770485 |
[Au] Autor: | da Silva Teixeira S; Filgueira C; Sieglaff DH; Benod C; Villagomez R; Minze LJ; Zhang A; Webb P; Nunes MT |
[Ad] Endereço: | Departamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil. |
[Ti] Título: | 3,5-diiodothyronine (3,5-T2) reduces blood glucose independently of insulin sensitization in obese mice. |
[So] Source: | Acta Physiol (Oxf);220(2):238-250, 2017 Jun. | [Is] ISSN: | 1748-1716 |
[Cp] País de publicação: | England |
[La] Idioma: | eng |
[Ab] Resumo: | AIM: Thyroid hormones regulate metabolic response. While triiodothyronine (T3) is usually considered to be the active form of thyroid hormone, one form of diiodothyronine (3,5-T2) exerts T3-like effects on energy consumption and lipid metabolism. 3,5-T2 also improves glucose tolerance in rats and 3,5-T2 levels correlate with fasting glucose in humans. Presently, however, little is known about mechanisms of 3,5-T2 effects on glucose metabolism. Here, we set out to compare effects of T3, 3,5-T2 and another form of T2 (3,3-T2) in a mouse model of diet-induced obesity and determined effects of T3 and 3,5-T2 on markers of classical insulin sensitization to understand how diiodothyronines influence blood glucose. METHODS: Cell- and protein-based assays of thyroid hormone action. Assays of metabolic parameters in mice. Analysis of transcript and protein levels in different tissues by qRT-PCR and Western blot. RESULTS: T3 and 3,5-T2 both reduce body weight, adiposity and body temperature despite increased food intake. 3,3'-T2 lacks these effects. T3 and 3,5-T2 reduce blood glucose levels, whereas 3,3'-T2 worsens glucose tolerance. Neither T3 nor 3,5-T2 affects markers of insulin sensitization in skeletal muscle or white adipose tissue (WAT), but both reduce hepatic GLUT2 glucose transporter levels and glucose output. T3 and 3,5-T2 also induce expression of mitochondrial uncoupling proteins (UCPs) 3 and 1 in skeletal muscle and WAT respectively. CONCLUSIONS: 3,5-T2 influences glucose metabolism in a manner that is distinct from insulin sensitization and involves reductions in hepatic glucose output and changes in energy utilization. |
[Mh] Termos MeSH primário: |
Glicemia/efeitos dos fármacos Di-Iodotironinas/farmacologia Resistência à Insulina
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[Mh] Termos MeSH secundário: |
Animais Dieta Hiperlipídica Metabolismo Energético/efeitos dos fármacos Células Hep G2 Seres Humanos Masculino Camundongos Camundongos Endogâmicos C57BL Obesidade Tri-Iodotironina/farmacologia
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Blood Glucose); 0 (Diiodothyronines); 06LU7C9H1V (Triiodothyronine); 534-51-0 (3,5-diiodothyronine); 70-40-6 (3,3'-diiodothyronine) |
[Em] Mês de entrada: | 1803 |
[Cu] Atualização por classe: | 180307 |
[Lr] Data última revisão:
| 180307 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 161023 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1111/apha.12821 |
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