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[PMID]:28455260
[Au] Autor:Mikolajczyk-Stecyna J; Malinowska AM; Chmurzynska A
[Ad] Endereço:Molecular Metabolism Laboratory, Department of Human Nutrition and Hygiene, Faculty of Food Sciences, Poznan University of Life Sciences, Wojska Polskiego 31, 60-624 Poznan, Poland. Electronic address: joanstec@up.poznan.pl.
[Ti] Título:TAS2R38 and CA6 genetic polymorphisms, frequency of bitter food intake, and blood biomarkers among elderly woman.
[So] Source:Appetite;116:57-64, 2017 09 01.
[Is] ISSN:1095-8304
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Taste sensitivity is one of the most important biological determinants of food choice. Three SNPs of the TAS2R38 gene (rs713598, rs1726866, and rs10246939) give rise to two common haplotypes: PAV and AVI. These haplotypes, as well as an SNP within the CA6 gene (rs2274333) that encodes carbonic anhydrase VI (CA6), correlate with bitterness perception. The extent of consumption of bitter food may influence some health outcomes. The aim of this study is thus to investigate the impact of the TAS2R38 and CA6 genetic polymorphisms on the choice of bitter food, BMI, blood lipoprotein, and glucose concentrations as well as systemic inflammation in elderly women. METHODS: The associations between the TAS2R38 diplotype, CA6 genotype, and the intake of bitter-tasting foods were studied in a group of 118 Polish women over 60 years of age. The intake of Brassica vegetables, grapefruit, and coffee was assessed using a food frequency questionnaire. Biochemical parameters were measured using the spectrophotometric method. Genotyping was performed using the high resolution melting method. RESULTS: We found a correlation between lipid profile, glucose and CRP levels, and frequency of bitter food intake. The AVI/AVI subjects drank coffee more frequently than did the PAV/PAV homozygotes, as did the A carriers of CA6 in comparison with the GG homozygotes. We also observed that simultaneous carriers of the PAV haplotype and A allele of TAS2R38 and CA6, respectively, choose white cabbage more frequent and had lower plasma levels of CRP and glucose than did AVI/AVI and GG homozygotes. CONCLUSIONS: In elderly women, the TAS2R38 and CA6 polymorphisms may affect the frequency of consumption of coffee and white cabbage, but not of other bitter-tasting foods.
[Mh] Termos MeSH primário: Anidrases Carbônicas/genética
Fenômenos Fisiológicos da Nutrição do Idoso
Preferências Alimentares
Polimorfismo de Nucleotídeo Único
Receptores Acoplados a Proteínas-G/genética
Percepção Gustatória/genética
[Mh] Termos MeSH secundário: Idoso
Alelos
Biomarcadores/sangue
Brassica
Anidrases Carbônicas/metabolismo
Citrus paradisi
Café
Feminino
Frutas
Frequência do Gene
Estudos de Associação Genética
Seres Humanos
Meia-Idade
Polônia
Receptores Acoplados a Proteínas-G/metabolismo
Autorrelato
Paladar
Verduras
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Coffee); 0 (Receptors, G-Protein-Coupled); 0 (taste receptors, type 2); EC 4.2.1.1 (Carbonic Anhydrases); EC 4.2.1.1 (carbonic anhydrase VI)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:28406464
[Au] Autor:Granic A; Hill TR; Davies K; Jagger C; Adamson A; Siervo M; Kirkwood TB; Mathers JC; Sayer AA
[Ad] Endereço:Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. antoneta.granic@newcastle.ac.uk.
[Ti] Título:Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study.
[So] Source:Nutrients;9(4), 2017 Apr 13.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Mixed reports exist about the role of 25-hydroxyvitamin D (25(OH)D) in muscle ageing and there are few prospective studies involving the very old (aged ≥ 85) who are at highest risk of low 25(OH)D, loss of muscle mass and strength, and physical performance decline. In the Newcastle 85+ Study ( = 845), we aimed to determine the association between 25(OH)D season-specific quartiles (hereafter SQ1-SQ4), grip strength (GS) and physical performance decline (Timed Up-and-Go Test, TUG) over 5 years using mixed models. In the time-only models with linear and quadratic slopes, SQ1 and SQ4 of 25(OH)D were associated with weaker GS initially in men (SQ1: ß (SE) = -2.56 (0.96); SQ4: -2.16 (1.06)) and women (SQ1: -1.10 (0.52); SQ4: -1.28 (0.50)) (all ≤ 0.04). In the fully adjusted models, only men in SQ1 had a significant annual decline in GS of 1.41 kg which accelerated over time (-0.40 (0.1)), (both ≤ 0.003) compared with those in combined middle quartiles. Only women in SQ1 and SQ4 of 25(OH)D had worse TUG times initially, but the rate of TUG decline was not affected. Low baseline 25(OH)D may contribute to muscle strength decline in the very old and particularly in men.
[Mh] Termos MeSH primário: Suplementos Nutricionais
Fenômenos Fisiológicos da Nutrição do Idoso
Força Muscular
Estado Nutricional
Sarcopenia/prevenção & controle
Deficiência de Vitamina D/dietoterapia
Vitamina D/uso terapêutico
[Mh] Termos MeSH secundário: 25-Hidroxivitamina D 2/sangue
Idoso de 80 Anos ou mais
Calcifediol/sangue
Estudos de Coortes
Progressão da Doença
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Estudos Prospectivos
Desempenho Psicomotor
Risco
Sarcopenia/epidemiologia
Sarcopenia/fisiopatologia
Estações do Ano
Autorrelato
Fatores Sexuais
Reino Unido/epidemiologia
Deficiência de Vitamina D/sangue
Deficiência de Vitamina D/epidemiologia
Deficiência de Vitamina D/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
1406-16-2 (Vitamin D); 21343-40-8 (25-Hydroxyvitamin D 2); P6YZ13C99Q (Calcifediol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE


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[PMID]:28368340
[Au] Autor:Milan AM; Pundir S; Pileggi CA; Markworth JF; Lewandowski PA; Cameron-Smith D
[Ad] Endereço:Liggins Institute, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand. a.milan@auckland.ac.nz.
[Ti] Título:Comparisons of the Postprandial Inflammatory and Endotoxaemic Responses to Mixed Meals in Young and Older Individuals: A Randomised Trial.
[So] Source:Nutrients;9(4), 2017 Apr 02.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Postprandial inflammation and endotoxaemia are determinants of cardiovascular and metabolic disease risk which are amplified by high fat meals. We aimed to examine the determinants of postprandial inflammation and endotoxaemia in older and younger adults following a high fat mixed meal. In a randomised cross-over trial, healthy participants aged 20-25 and 60-75 years ( = 15/group) consumed a high-fat breakfast and a low-fat breakfast. Plasma taken at baseline and post-meal for 5 h was analysed for circulating endotoxin, cytokines (monocyte chemotactic protein-1 (MCP-1), interleukin (IL)-1ß, IL-6, and tumour necrosis factor-alpha (TNF-α)), lipopolysaccharide binding protein (LBP), and inflammatory gene expression in peripheral blood mononuclear cells (PBMC). Older subjects had lower baseline PBMC expression of Glutathione peroxidase 1 (GPX-1) but greater insulin-like growth factor-binding protein 3 (IGFBP3) and circulating MCP-1 compared to younger subjects. After either meal, there were no age differences in plasma, chylomicron endotoxin, or plasma LBP concentrations, nor in inflammatory cytokine gene and protein expression (MCP-1, IL-1ß, and TNF-α). Unlike younger participants, the older group had decreased superoxide dismutase (SOD)-2 expression after the meals. After a high-fat meal, older adults have no increased inflammatory or endotoxin response, but an altered oxidative stress gene response compared with younger adults. Healthy older adults, without apparent metabolic dysfunction, have a comparable postprandial inflammatory and endotoxaemia response to younger adults.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/etiologia
Dieta Hiperlipídica/efeitos adversos
Fenômenos Fisiológicos da Nutrição do Idoso
Regulação da Expressão Gênica no Desenvolvimento
Leucócitos Mononucleares/metabolismo
Doenças Metabólicas/etiologia
Vasculite/etiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Biomarcadores/sangue
Biomarcadores/metabolismo
Desjejum
Doenças Cardiovasculares/epidemiologia
Doenças Cardiovasculares/imunologia
Doenças Cardiovasculares/metabolismo
Estudos de Coortes
Estudos Cross-Over
Feminino
Seres Humanos
Mediadores da Inflamação/sangue
Mediadores da Inflamação/metabolismo
Leucócitos Mononucleares/imunologia
Masculino
Doenças Metabólicas/epidemiologia
Doenças Metabólicas/imunologia
Doenças Metabólicas/metabolismo
Meia-Idade
Nova Zelândia/epidemiologia
Período Pós-Prandial
Fatores de Risco
Vasculite/imunologia
Vasculite/metabolismo
Vasculite/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biomarkers); 0 (Inflammation Mediators)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE


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[PMID]:28273828
[Au] Autor:Du K; Liu M; Pan Y; Zhong X; Wei M
[Ad] Endereço:School of Pharmacy, Department of Pharmacology, China Medical University, Shenyang 110122, China. kdu@cmu.edu.
[Ti] Título:Association of Serum Manganese Levels with  Alzheimer's Disease and Mild Cognitive Impairment:  A Systematic Review and Meta-Analysis.
[So] Source:Nutrients;9(3), 2017 Mar 03.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Manganese (Mn) is one of the most studied environmental heavy metals linked to Alzheimer's disease (AD). However, it remains unclear whether serum Mn levels are associated with AD and mild cognition impairment (MCI, a prodromal stage of AD). We conducted a metaanalysis to analyze the serum Mn levels in patients with AD and MCI. A systematic database search of PubMed, Web of Science, and the China National Knowledge Infrastructure (CNKI) identified 17 studies, including 836 cases and 1254 health controls (HC). Random-effects meta-analysis showed that patients with AD had significantly reduced serum Mn levels compared with HC subjects (SMD = -0.39; 95% CI (-0.71, -0.08); p = 0.015). MCI individuals had a tendency toward reduced serum Mn levels compared with HC subjects (SMD = -0.31; 95% CI (-0.70, 0.08); p = 0.117). A significant decrease in serum Mn levels was found in patients with cognitive impairment (including both AD patients and MCI patients) (SMD = -0.37, 95% CI (-0.60; -0.13); p = 0.002). Finally, no significant differences were observed between AD and MCI patients in serum levels (SMD = 0.24; 95% CI (-0.23, 0.72); p = 0.310). Our findings show that the serum Mn levels are lower in AD patients, and Mn deficiency may be a risk factor for AD.
[Mh] Termos MeSH primário: Envelhecimento
Doença de Alzheimer/sangue
Disfunção Cognitiva/sangue
Deficiências Nutricionais/fisiopatologia
Fenômenos Fisiológicos da Nutrição do Idoso
Medicina Baseada em Evidências
Manganês/sangue
[Mh] Termos MeSH secundário: Doença de Alzheimer/induzido quimicamente
Doença de Alzheimer/epidemiologia
Doença de Alzheimer/etiologia
Animais
Disfunção Cognitiva/induzido quimicamente
Disfunção Cognitiva/epidemiologia
Disfunção Cognitiva/etiologia
Deficiências Nutricionais/etiologia
Dieta/efeitos adversos
Poluentes Ambientais/sangue
Poluentes Ambientais/toxicidade
Seres Humanos
Manganês/deficiência
Manganês/toxicidade
Sintomas Prodrômicos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (Environmental Pollutants); 42Z2K6ZL8P (Manganese)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE


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[PMID]:27789618
[Au] Autor:Jung A; Spira D; Steinhagen-Thiessen E; Demuth I; Norman K
[Ad] Endereço:Charité Research Group on Geriatrics.
[Ti] Título:Zinc Deficiency Is associated With Depressive Symptoms-Results From the Berlin Aging Study II.
[So] Source:J Gerontol A Biol Sci Med Sci;72(8):1149-1154, 2017 Aug 01.
[Is] ISSN:1758-535X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Zinc plays an important role for behavioral and mental function, maintaining the correct functions of intracellular signal transduction, cellular and trans-membrane transport, protein synthesis, and antioxidant system. We investigated both dietary zinc intake and plasma zinc levels and the correlation with depressive symptoms in a large sample of community-dwelling old. Design: One thousand five hundred fourteen older people (aged 60-84 years, 772 women) from the Berlin Aging Study II were included. Zinc intake was assessed by the EPIC Food Frequency Questionnaire. Plasma zinc levels were assessed with atomic-absorption spectrophotometry. Depressive symptoms were assessed with the "Center for Epidemiological Studies Depression Scale" and the "Geriatric Depression Scale." Results: Zinc deficiency in blood plasma was found in 18.7% of participants, and depressive symptoms in 15.7%. Participants with depressive symptoms had lower energy-adjusted zinc intake (median 11.1 vs 11.6 µmol/L; p = .048) and lower plasma zinc levels (median 12.2 vs12.3 mg/dL; p = .037). Even after adjustment for known predictors of depression, plasma zinc deficiency remained significantly associated with depressive symptoms (odds ratio: 1.490, 95% confidence interval: 1.027-2.164; p = .036). In the multiple logistic regression model stratified by sex, we found that plasma zinc deficiency was strongly associated with a higher risk for depressive symptoms in women (odds ratio: 1.739, 95% confidence interval: 1.068-2.833; p = .026). Conclusions: Plasma zinc deficiency was common in our old study population. An increase in dietary zinc and higher plasma zinc levels may reduce the risk of depressive symptoms. A screening for reduced dietary zinc intake or plasma zinc deficiency might be beneficial in older people at risk of depressive symptoms.
[Mh] Termos MeSH primário: Depressão
Fenômenos Fisiológicos da Nutrição do Idoso/fisiologia
Zinco
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Estudos de Coortes
Depressão/diagnóstico
Depressão/epidemiologia
Depressão/metabolismo
Depressão/prevenção & controle
Feminino
Alemanha/epidemiologia
Seres Humanos
Masculino
Meia-Idade
Necessidades Nutricionais
Estudos Prospectivos
Escalas de Graduação Psiquiátrica
Fatores de Risco
Fatores Sexuais
Estatística como Assunto
Zinco/sangue
Zinco/deficiência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE
[do] DOI:10.1093/gerona/glw218


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[PMID]:27717662
[Au] Autor:Oh C; Jeon BH; Reid Storm SN; Jho S; No JK
[Ad] Endereço:Department of Food and Nutrition, Kyungsung University, Busan, South Korea.
[Ti] Título:The most effective factors to offset sarcopenia and obesity in the older Korean: Physical activity, vitamin D, and protein intake.
[So] Source:Nutrition;33:169-173, 2017 Jan.
[Is] ISSN:1873-1244
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study was to evaluate the effects of the types and levels of physical activity in conjunction with protein intake and vitamin D on sarcopenia and obesity status in an elderly population. METHODS: Study participants (N = 4452) were ages ≥60 y and included 1929 men and 2523 women who completed a body composition analysis with a dual energy x-ray absorptiometry and provided health and dietary data. RESULTS: Higher appendicular skeletal muscle mass/weight was observed in the non-obese group, although obese participants had greater weights. The non-obese sarcopenia subgroup showed health problems related to insulin resistance and metabolic-related factors compared with the nonsarcopenic group. The total metabolic equivalent was significantly different in both obese categories, regardless of sarcopenic status. The prevalence of obesity, sarcopenia, and sarcopenic obesity relatively increased with a diet deficient of protein intake and vitamin D. CONCLUSION: These data suggest that sarcopenia had a significant association with metabolic-related factors; physical activity, especially vigorous activity; and protein intake and vitamin D levels in a non-obese elderly population. Therefore, maintaining healthy body weight by means of resistance exercise and enhanced protein intake and vitamin D may help offset sarcopenia in this age group.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos da Nutrição do Idoso
Dieta Saudável
Estilo de Vida Saudável
Obesidade/prevenção & controle
Sobrepeso/prevenção & controle
Sarcopenia/prevenção & controle
Deficiência de Vitamina D/prevenção & controle
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Índice de Massa Corporal
Estudos de Coortes
Estudos Transversais
Proteínas na Dieta/administração & dosagem
Proteínas na Dieta/uso terapêutico
Fenômenos Fisiológicos da Nutrição do Idoso/etnologia
Exercício
Feminino
Dieta Saudável/etnologia
Seres Humanos
Incidência
Masculino
Meia-Idade
Inquéritos Nutricionais
Obesidade/complicações
Obesidade/epidemiologia
Obesidade/etnologia
Sobrepeso/complicações
Sobrepeso/epidemiologia
Sobrepeso/etnologia
Prevalência
República da Coreia/epidemiologia
Sarcopenia/complicações
Sarcopenia/epidemiologia
Sarcopenia/etnologia
Deficiência de Vitamina D/complicações
Deficiência de Vitamina D/epidemiologia
Deficiência de Vitamina D/etnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Proteins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161009
[St] Status:MEDLINE


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[PMID]:28065177
[Au] Autor:Gopinath B; Flood VM; Burlutksy G; Louie JC; Mitchell P
[Ad] Endereço:1Centre for Vision Research,The Westmead Institute,The University of Sydney,Sydney,NSW 2145,Australia.
[Ti] Título:Association between carbohydrate nutrition and prevalence of depressive symptoms in older adults.
[So] Source:Br J Nutr;116(12):2109-2114, 2016 Dec.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We aimed to examine the relationship between dietary glycaemic index (GI) and glycaemic load of foods consumed, intakes of carbohydrates, sugars and fibre, and the prevalence of depressive symptoms in older adults. Data collected from 2334 participants aged 55+ years and 1952 participants aged 60+ years were analysed. Dietary information was collected using a semi-quantitative FFQ. Depressive symptoms were based on antidepressant use or either the 36-Item Short-Form Survey, which included the Mental Health Index (MHI), or the Center for Epidemiologic Studies Depression-10 Scale. Participants in the highest v. lowest tertile of dietary GI intake had increased odds of depressive symptoms (assessed by the MHI scale), multivariable-adjusted OR 1·55 (95 % CI 1·12, 2·14). Participants in the highest compared with lowest tertile of fruit consumption had reduced odds of prevalent depressive symptoms, multivariable-adjusted OR 0·66 (95 % CI 0·46, 0·95). Total fibre, vegetable fibre and breads/cereal fibre intakes were all inversely associated with the prevalence of depressive symptoms, with global P values of 0·03, 0·01 and 0·03, respectively. Participants in the second v. first tertile of vegetable consumption had 41 % reduced odds of prevalent depressive symptoms, multivariable-adjusted OR 0·59 (95 % CI 0·40, 0·88). We show that dietary GI and fibre intakes as well as consumption of fruits and vegetables are associated with the prevalence of depressive symptoms.
[Mh] Termos MeSH primário: Depressão/etiologia
Dieta da Carga de Carboidratos/efeitos adversos
Fenômenos Fisiológicos da Nutrição do Idoso
Índice Glicêmico
Carga Glicêmica
Saúde Suburbana
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Antidepressivos/uso terapêutico
Estudos de Coortes
Estudos Transversais
Depressão/tratamento farmacológico
Depressão/epidemiologia
Depressão/prevenção & controle
Dieta da Carga de Carboidratos/psicologia
Feminino
Seguimentos
Dieta Saudável/psicologia
Seres Humanos
Masculino
Meia-Idade
New South Wales/epidemiologia
Inquéritos Nutricionais
Prevalência
Escalas de Graduação Psiquiátrica
Risco
Autorrelato
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Antidepressive Agents)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114516004311


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[PMID]:27893068
[Au] Autor:Iversen OE; Miranda MJ; Ulied A; Soerdal T; Lazarus E; Chokephaibulkit K; Block SL; Skrivanek A; Nur Azurah AG; Fong SM; Dvorak V; Kim KH; Cestero RM; Berkovitch M; Ceyhan M; Ellison MC; Ritter MA; Yuan SS; DiNubile MJ; Saah AJ; Luxembourg A
[Ad] Endereço:Department of Obstetrics and Gynecology, Haukeland University Hospital, University of Bergen, Bergen, Norway.
[Ti] Título:Immunogenicity of the 9-Valent HPV Vaccine Using 2-Dose Regimens in Girls and Boys vs a 3-Dose Regimen in Women.
[So] Source:JAMA;316(22):2411-2421, 2016 12 13.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Human papillomavirus (HPV) infections cause anogenital cancers and warts. The 9-valent HPV vaccine provides protection against 7 high-risk types of HPV responsible for 90% of cervical cancers and 2 other HPV types accounting for 90% of genital warts. Objective: To determine whether HPV type-specific antibody responses would be noninferior among girls and boys aged 9 to 14 years after receiving 2 doses of the 9-valent HPV vaccine compared with adolescent girls and young women aged 16 to 26 years receiving 3 doses. Design, Setting, and Participants: Open-label, noninferiority, immunogenicity trial conducted at 52 ambulatory care sites in 15 countries. The study was initiated on December 16, 2013, with the last participant visit for this report on June 19, 2015. Five cohorts were enrolled: (1) girls aged 9 to 14 years to receive 2 doses 6 months apart (n = 301); (2) boys aged 9 to 14 years to receive 2 doses 6 months apart (n = 301); (3) girls and boys aged 9 to 14 years to receive 2 doses 12 months apart (n = 301); (4) girls aged 9 to 14 years to receive 3 doses over 6 months (n = 301); and (5) a control group of adolescent girls and young women aged 16 to 26 years to receive 3 doses over 6 months (n = 314). Interventions: Two doses of the 9-valent HPV vaccine administered 6 or 12 months apart or 3 doses administered over 6 months. Main Outcomes and Measures: The primary end point was prespecified as the antibody response against each HPV type assessed 1 month after the last dose using a competitive immunoassay. Each of the three 2-dose regimens was compared with the standard 3-dose schedule in adolescent girls and young women using a noninferiority margin of 0.67 for the ratio of the antibody geometric mean titers. Results: Of the 1518 participants (753 girls [mean age, 11.4 years]; 451 boys [mean age, 11.5 years]; and 314 adolescent girls and young women [mean age, 21.0 years]), 1474 completed the study and data from 1377 were analyzed. At 4 weeks after the last dose, HPV antibody responses in girls and boys given 2 doses were noninferior to HPV antibody responses in adolescent girls and young women given 3 doses (P < .001 for each HPV type). Compared with adolescent girls and young women who received 3 doses over 6 months, the 1-sided 97.5% CIs for the ratio of HPV antibody geometric mean titers at 1 month after the last dose across the 9 HPV subtypes ranged from 1.36 to ∞ to 2.50 to ∞ for girls who received 2 doses 6 months apart; from 1.37 to ∞ to 2.55 to ∞ for boys who received 2 doses 6 months apart; and from 1.61 to ∞ to 5.36 to ∞ for girls and boys who received 2 doses 12 months apart. Conclusions and Relevance: Among girls and boys aged 9 to 14 years receiving 2-dose regimens of a 9-valent HPV vaccine separated by 6 or 12 months, immunogenicity 4 weeks after the last dose was noninferior to a 3-dose regimen in a cohort of adolescent girls and young women. Further research is needed to assess persistence of antibody responses and effects on clinical outcomes. Trial Registration: clinicaltrials.gov Identifier: NCT01984697.
[Mh] Termos MeSH primário: Esquemas de Imunização
Infecções por Papillomavirus/prevenção & controle
Vacinas contra Papillomavirus/administração & dosagem
Vacinas contra Papillomavirus/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Especificidade de Anticorpos
Criança
Estudos de Coortes
Fenômenos Fisiológicos da Nutrição do Idoso
Feminino
Genótipo
Seres Humanos
Imunogenicidade da Vacina
Masculino
Papillomaviridae/genética
Papillomaviridae/imunologia
Vacinas contra Papillomavirus/efeitos adversos
Fatores Sexuais
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Papillomavirus Vaccines)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170208
[Lr] Data última revisão:
170208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161129
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2016.17615


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[PMID]:27788696
[Au] Autor:McHugh Power JE; Lee O; Aspell N; McCormack E; Loftus M; Connolly L; Lawlor B; Brennan S
[Ad] Endereço:Room 3.10, Institute of Neuroscience,Trinity College,Dublin 2, D02 AP03,Republic of Ireland.
[Ti] Título:RelAte: pilot study of the effects of a mealtime intervention on social cognitive factors and energy intake among older adults living alone.
[So] Source:Br J Nutr;116(9):1573-1581, 2016 Nov.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mealtime interventions typically focus on institutionalised older adults, but we wanted to investigate whether they may also be effective among those living independently. Using a randomised controlled trial design, we assessed the effects of a novel mealtime intervention on self-efficacy, food enjoyment and energy intake. A total of 100 adults living alone aged over 60 years were randomised to the treatment or control conditions: all received a guidebook on nutrition and culinary skills. Treatment group participants received a weekly visit from a trained volunteer who prepared and shared a meal with them. Participants in the treatment group showed improvements relative to those in the control group at borderline significance (P=0·054) for self-efficacy and at significance for food enjoyment. Significant improvements were observed in female participants in the treatment but not in the control group in energy intake (although following corrections for multiple comparisons, only the effect on food enjoyment remained significant). These findings will inform the design of future complex interventions. For this type of intervention to be successful, more focus has to be placed on making interventions more personalised, potentially according to sex. Findings are important for nutritional sciences as they indicate that, in order to improve energy intake and food enjoyment among older adults, multimodal nutritional interventions including social components may be successful.
[Mh] Termos MeSH primário: Envelhecimento Cognitivo
Fenômenos Fisiológicos da Nutrição do Idoso
Ingestão de Energia
Desnutrição/prevenção & controle
Refeições
Sistemas de Apoio Psicossocial
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Envelhecimento Cognitivo/psicologia
Estudos de Coortes
Feminino
Seguimentos
Seres Humanos
Irlanda/epidemiologia
Masculino
Desnutrição/epidemiologia
Desnutrição/psicologia
Refeições/psicologia
Meia-Idade
Projetos Piloto
Prazer
Risco
Autoeficácia
Pessoa Solteira/psicologia
Isolamento Social/psicologia
Viuvez/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE


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[PMID]:27534645
[Au] Autor:Miles LM; Allen E; Mills K; Clarke R; Uauy R; Dangour AD
[Ad] Endereço:Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom;
[Ti] Título:Vitamin B-12 status and neurologic function in older people: a cross-sectional analysis of baseline trial data from the Older People and Enhanced Neurological Function (OPEN) study.
[So] Source:Am J Clin Nutr;104(3):790-6, 2016 Sep.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Aging is associated with a progressive decline in vitamin B-12 status. Overt vitamin B-12 deficiency causes neurologic disturbances in peripheral and central motor and sensory systems, but the public health impact for neurologic disease of moderately low vitamin B-12 status in older people is unclear. Evidence from observational studies is limited by heterogeneity in the definition of vitamin B-12 status and imprecise measures of nerve function. OBJECTIVE: We aimed to determine whether vitamin B-12 status is associated with electrophysiologic indexes of peripheral or central neurologic function in asymptomatic older people with moderately low vitamin B-12 status. DESIGN: We used a cross-sectional analysis of baseline data from the Older People and Enhanced Neurological Function study conducted in Southeast England. This trial investigated the effectiveness of vitamin B-12 supplementation on electrophysiologic indexes of neurologic function in asymptomatic older people (mean age: 80 y) with moderately low vitamin B-12 status (serum vitamin B-12 concentrations ≥107 and <210 pmol/L without anemia, n = 201). Vitamin B-12 status was assessed with the use of total vitamin B-12, holotranscobalamin, and a composite indicator of vitamin B-12 status (cB-12). Electrophysiologic measures of sensory and motor components of peripheral and central nerve function were assessed in all participants by a single observer. RESULTS: In multivariate models, there was no evidence of an association of vitamin B-12, holotranscobalamin, or cB-12 with any nerve conduction outcome. There was also no evidence of an association of vitamin B-12 status with clinical markers of neurologic function. CONCLUSION: This secondary analysis of high-quality trial data did not show any association of any measure of vitamin B-12 status with either peripheral or central neurologic function or any clinical markers of neurologic function in older people with moderately low vitamin B-12 status. The results of this study are unlikely to be generalizable to a less healthy older population with more severe vitamin B-12 deficiency. This trial was registered at www.controlled-trials.com as ISRCTN54195799.
[Mh] Termos MeSH primário: Doenças Assintomáticas
Doenças do Sistema Nervoso Central/etiologia
Fenômenos Fisiológicos da Nutrição do Idoso
Estado Nutricional
Doenças do Sistema Nervoso Periférico/etiologia
Deficiência de Vitamina B 12/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Doenças Assintomáticas/epidemiologia
Biomarcadores/sangue
Doenças do Sistema Nervoso Central/diagnóstico
Doenças do Sistema Nervoso Central/epidemiologia
Doenças do Sistema Nervoso Central/prevenção & controle
Fatores de Confusão (Epidemiologia)
Estudos Transversais
Suplementos Nutricionais
Método Duplo-Cego
Fenômenos Eletrofisiológicos
Inglaterra/epidemiologia
Feminino
Avaliação Geriátrica
Seres Humanos
Masculino
Análise Multivariada
Condução Nervosa
Exame Neurológico
Doenças do Sistema Nervoso Periférico/diagnóstico
Doenças do Sistema Nervoso Periférico/epidemiologia
Doenças do Sistema Nervoso Periférico/prevenção & controle
Índice de Gravidade de Doença
Vitamina B 12/uso terapêutico
Deficiência de Vitamina B 12/sangue
Deficiência de Vitamina B 12/dietoterapia
Deficiência de Vitamina B 12/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biomarkers); P6YC3EG204 (Vitamin B 12)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160819
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.137927



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