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[PMID]:29300916
[Au] Autor:Kougias DG; Cortes LR; Moody L; Rhoads S; Pan YX; Juraska JM
[Ad] Endereço:Neuroscience Program, University of Illinois, Champaign, Illinois.
[Ti] Título:Effects of Perinatal Exposure to Phthalates and a High-Fat Diet on Maternal Behavior and Pup Development and Social Play.
[So] Source:Endocrinology;159(2):1088-1105, 2018 02 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Humans are ubiquitously exposed to many phthalates, a class of endocrine-disrupting chemicals commonly used in many consumer goods, and diet, especially fatty food, is presumed to be a major source of exposure. Here, we use a rat model of human prenatal exposure to investigate the potential interactive effects of an environmentally relevant mixture of phthalates and a maternal high-fat diet (HFD). From gestation through postnatal day (P)10, dams consumed the mixture of phthalates (0, 200, or 1000 µg/kg/d) and were fed a control diet or HFD. In males, perinatal exposure to the mixture of phthalates decreased prepubertal body weight and, in a dose-specific manner, periadolescent social play behavior. A dose-specific effect from phthalates with HFD was also seen in increased time alone in females during social play. HFD resulted in dams consuming more calories, having greater gestational weight gain, and licking and nursing their pups more, such that an early postnatal HFD generally increased pup body weight. There also was a tendency for increased oxidative stress markers at P10 within the medial prefrontal cortex of males exposed to the relatively high dose of phthalates and HFD. Effects on gene expression were inconsistent at P10 and P90 in both the medial prefrontal cortex and hypothalamus. Overall, this study demonstrates that phthalates and a maternal HFD only rarely interacted, except in oxidative stress markers in males. Additionally, perinatal exposure to an environmentally relevant mixture of phthalates can have a modest, but lasting, impact on social behaviors in both males and females.
[Mh] Termos MeSH primário: Dieta Hiperlipídica
Crescimento/efeitos dos fármacos
Comportamento Materno/efeitos dos fármacos
Ácidos Ftálicos/toxicidade
Jogos e Brinquedos
Efeitos Tardios da Exposição Pré-Natal
Comportamento Social
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Dieta Hiperlipídica/efeitos adversos
Feminino
Masculino
Fenômenos Fisiológicos da Nutrição Materna
Jogos e Brinquedos/psicologia
Gravidez
Efeitos Tardios da Exposição Pré-Natal/fisiopatologia
Efeitos Tardios da Exposição Pré-Natal/psicologia
Ratos
Ratos Long-Evans
Maturidade Sexual/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Phthalic Acids); 6O7F7IX66E (phthalic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-03047


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[PMID]:29186387
[Au] Autor:Ros P; Díaz F; Freire-Regatillo A; Argente-Arizón P; Barrios V; Argente J; Chowen JA
[Ad] Endereço:Hospital Universitario Puerto de Hierro-Majadahonda, Madrid, Spain.
[Ti] Título:Resveratrol Intake During Pregnancy and Lactation Modulates the Early Metabolic Effects of Maternal Nutrition Differently in Male and Female Offspring.
[So] Source:Endocrinology;159(2):810-825, 2018 02 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Poor maternal nutrition can have detrimental long-term consequences on energy homeostasis in the offspring. Resveratrol exerts antioxidant and antiobesity actions, but its impact during development remains largely unknown. We hypothesized that resveratrol intake during pregnancy and lactation could improve the effects of poor maternal nutrition on offspring metabolism. Wistar rats received a low-fat diet (LFD; 10.2% kcal from fat) or high-fat diet (HFD; 61.6% kcal from fat), with half of each group receiving resveratrol in their drinking water (50 mg/L) during pregnancy and lactation. Body weight (BW) of dams was measured at treatment onset and weaning [postnatal day (PND) 21] and of pups at birth and PND21, at which time dams and pups were euthanized. Although HFD dams consumed more energy, their BW at the end of lactation was unaffected. Mean litter size was not modified by maternal diet or resveratrol. At birth, male offspring from HFD and resveratrol (HFD + R) dams weighed less than those from LFD and resveratrol (LFD + R) dams. On PND21, pups of both sexes from HFD dams weighed more, had more visceral adipose tissue (VAT) and subcutaneous adipose tissue (SCAT), and had higher serum leptin levels than those from LFD dams. Resveratrol reduced BW, leptin, VAT, and SCAT, with females being more affected, but increased glycemia. Neuropeptide levels were unaffected by resveratrol. In conclusion, resveratrol intake during pregnancy and lactation decreased BW and adipose tissue content in offspring of dams on an HFD but did not affect offspring from LFD-fed dams, suggesting that the potential protective effects of resveratrol during gestation/lactation are diet dependent.
[Mh] Termos MeSH primário: Lactação/efeitos dos fármacos
Fenômenos Fisiológicos da Nutrição Materna
Efeitos Tardios da Exposição Pré-Natal/metabolismo
Estilbenos/farmacologia
[Mh] Termos MeSH secundário: Fenômenos Fisiológicos da Nutrição Animal/efeitos dos fármacos
Animais
Ingestão de Alimentos/fisiologia
Feminino
Lactação/metabolismo
Masculino
Fenômenos Fisiológicos da Nutrição Materna/efeitos dos fármacos
Gravidez
Ratos
Ratos Wistar
Caracteres Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Stilbenes); Q369O8926L (resveratrol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00610


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[PMID]:29172662
[Au] Autor:Papp F; Rácz G; Lénárt I; Kóbor J; Bereczki C; Karg E; Baráth Á
[Ad] Endereço:Gyermekgyógyászati Klinika és Gyermek-egészségügyi Központ, Szegedi Tudományegyetem, Általános Orvostudományi Kar, Szent-Györgyi Albert Klinikai Központ Szeged, Korányi fasor 14-15., 6720.
[Ti] Título:[Maternal and neonatal vitamin B deficiency detected by expanded newborn screening].
[Ti] Título:Anyai és újszülöttkori B -vitamin-hiány felismerése kiterjesztett újszülöttkori szuréssel..
[So] Source:Orv Hetil;158(48):1909-1918, 2017 Dec.
[Is] ISSN:0030-6002
[Cp] País de publicação:Hungary
[La] Idioma:hun
[Ab] Resumo:INTRODUCTION: Infant vitamin B deficiency can manifest as a severe neurodegenerative disorder and is usually caused by maternal deficiency due to vegetarian diet or pernicious anaemia. Its early recognition and treatment can prevent potentially serious and irreversible neurologic damage. Biochemically, vitamin B deficiency leads to an accumulation of methylmalonic acid, homocysteine, and propionylcarnitine. Expanded newborn screening using tandem mass spectrometry may identify neonatal and maternal vitamin B deficiency by measurement of propionylcarnitine and other metabolites in the dried blood spot sample of newborns. AIM: To summarize our experiences gained by screening for vitamin B deficiency. METHOD: Clinical and laboratory data of vitamin B -deficient infants diagnosed in Szeged Screening Centre were retrospectively analysed. RESULTS: In Hungary, expanded newborn screening was introduced in 2007. Since then approximately 395 000 newborns were screened in our centre and among them, we identified four newborns with vitamin B deficiency based on their screening results. In three cases an elevated propionylcarnitine level and in the fourth one a low methionine level were indicative of vitamin B deficiency. We also detected an additional vitamin B -deficient infant with neurological symptoms at 4 months of age, after a normal newborn screening, because of elevated urinary methylmalonic acid concentration. Vitamin B deficiency was secondary to maternal autoimmune pernicious anaemia in all the five infants. As a result of the recognized cases the incidence of infant vitamin B deficiency in the East-Hungarian region was 1.26/100 000 births, but the real frequency may be higher. Conslusions: Optimizing the cut off values of current screening parameters and measuring of methylmalonic acid and/or homocysteine in the dried blood spot, as a second tier test, can improve recognition rate of vitamin B deficiency. Orv Hetil. 2017; 158(48): 1909-1918.
[Mh] Termos MeSH primário: Triagem Neonatal/métodos
Complicações na Gravidez/diagnóstico
Deficiência de Vitamina B 12/diagnóstico
[Mh] Termos MeSH secundário: Anemia Perniciosa/imunologia
Feminino
Seres Humanos
Hungria
Incidência
Recém-Nascido
Fenômenos Fisiológicos da Nutrição Materna
Gravidez
Estudos Retrospectivos
Espectrometria de Massas em Tandem
Deficiência de Vitamina B 12/sangue
Deficiência de Vitamina B 12/etiologia
Deficiência de Vitamina B 12/urina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1556/650.2017.30901


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Registro de Ensaios Clínicos
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[PMID]:28464867
[Au] Autor:Billah SM; Ferdous TE; Karim MA; Dibley MJ; Raihana S; Moinuddin M; Choudhury N; Ahmed T; Hoque DME; Menon P; Arifeen SE
[Ad] Endereço:Maternal and Child Health Division, icddr,b, 68 Shahid Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh. billah@icddrb.org.
[Ti] Título:A community-based cluster randomised controlled trial to evaluate the effectiveness of different bundles of nutrition-specific interventions in improving mean length-for-age z score among children at 24 months of age in rural Bangladesh: study protocol.
[So] Source:BMC Public Health;17(1):375, 2017 05 02.
[Is] ISSN:1471-2458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Prevalence of stunting among under-five children in Bangladesh is 36%, varying with geographic and socio-economic characteristics. Previously, research groups statistically modelled the effect of 10 individual nutrition-specific interventions targeting the critical first 1000 days of life from conception, on lives saved and costs incurred in countries with the highest burden of stunted children. However, primary research on the combined effects of these interventions is limited. Our study directly addresses this gap by examining the effect of combinations of 5 preventive interventions on length-for-age z-scores (LAZ) among 2-years old children. METHODS: This community-based cluster randomised trial (c-RCT) compares 4 intervention combinations against one comparison arm. Intervention combinations are: 1) Behaviour change communication (BCC) on maternal nutrition during pregnancy, exclusive breastfeeding, and complementary feeding, along with prenatal nutritional supplement (PNS) and complementary food supplement (CFS); 2) BCC with PNS; 3) BCC with CFS; and 4) BCC alone. The comparison arm receives only routine health and nutrition services. From a rural district, 125 clusters were selected and randomly assigned to any one of the five study arms by block randomisation. A bespoke automated tab-based system was developed linking data collection, intervention delivery and project supervision. Total sample size is 1500 pregnant women, with minimum 1050 resultant children expected to be retained, powered to detect a difference of at least 0.4 in the mean LAZ score of children at 24 months, the main outcome variable, between the comparison arm and each intervention arm. Length and other anthropometric measurements, nutritional intake and other relevant data on mother and children are being collected during enrolment, twice during pregnancy, postpartum monthly till 6 months, and every third month thereafter till 24 months. DISCUSSION: This c-RCT explores the effectiveness of bundles of preventive nutrition intervention approaches addressing the critical window of opportunity to mitigate childhood stunting. The results will provide robust evidence as to which bundle(s) can have significant effect on linear growth of children. Our study also will have policy-level implications for prioritising intervention(s) tackling stunting. TRIAL REGISTRATION: The study was retrospectively registered on May 2, 2016 and is available online at ClinicalTrials.gov (ID: NCT02768181 ).
[Mh] Termos MeSH primário: Suplementos Nutricionais
Transtornos do Crescimento/prevenção & controle
Comportamentos Relacionados com a Saúde
Mães
Pacotes de Assistência ao Paciente
[Mh] Termos MeSH secundário: Antropometria
Bangladesh
Aleitamento Materno
Desenvolvimento Infantil
Pré-Escolar
Feminino
Seres Humanos
Lactente
Fenômenos Fisiológicos da Nutrição do Lactente
Fenômenos Fisiológicos da Nutrição Materna
Estado Nutricional
Gravidez
Projetos de Pesquisa
População Rural
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180121
[Lr] Data última revisão:
180121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1186/s12889-017-4281-0


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[PMID]:29173222
[Au] Autor:Lavandera J; Gerstner CD; Saín J; Fariña AC; González MA; Bernal CA
[Ad] Endereço:1Cátedra de Bromatología y Nutrición, Facultad de Bioquímica y Ciencias Biológicas,Universidad Nacional del Litoral,Ciudad Universitaria, Paraje el Pozo S/N, C.C. 242 (C.P. 3000),Santa Fe,Argentina.
[Ti] Título:Maternal conjugated linoleic acid modulates TAG metabolism in adult rat offspring.
[So] Source:Br J Nutr;118(11):906-913, 2017 Dec.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Conjugated linoleic acid (CLA) might regulate the lipid depots in liver and adipose tissue. As there is an association between maternal nutrition, fat depots and risk of offspring chronic disease, the aim was to investigate the effect of maternal CLA consumption on TAG regulation and some inflammatory parameters in adult male rat offspring receiving or not receiving CLA. Female Wistar rats were fed control (C) or CLA-supplemented (1 %, w/w) diets during 4 weeks before and throughout pregnancy and lactation. After weaning, male offspring of CLA rats were fed C or CLA diets (CLA/C and CLA/CLA groups, respectively), whereas C male rat offspring were fed a C diet (C/C group) for 9 weeks. Serum TAG levels were increased in the CLA/CLA and CLA/C groups, associated with a reduction of lipoprotein lipase activity and weights of adipose tissue. The liver TAG levels were decreased in the CLA/CLA group, related to a significant reduction of fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC) and glucose-6-phosphate dehydrogenase enzyme activities, as well as to the mRNA levels of FAS, ACC, stearoyl-CoA desaturase-1 and sterol regulatory element-binding protein-1c. Even though normal TAG levels were found in the liver of CLA/C rats, a reduction of lipogenesis was also observed. Thus, these results demonstrated a programming effect of CLA on the lipid metabolic pathways leading to a preventive effect on the TAG accretion in adipose tissue and the liver of male rat offspring. This knowledge could be important to develop some dietary strategies leading to a reduced incidence of obesity and fatty acid liver disease in humans.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos da Nutrição Animal
Ácidos Linoleicos Conjugados/farmacologia
Triglicerídeos/sangue
Triglicerídeos/metabolismo
[Mh] Termos MeSH secundário: Acetil-CoA Carboxilase/genética
Acetil-CoA Carboxilase/metabolismo
Tecido Adiposo Branco/efeitos dos fármacos
Tecido Adiposo Branco/metabolismo
Animais
Dieta
Gorduras na Dieta/administração & dosagem
Gorduras na Dieta/sangue
Ácido Graxo Sintases/genética
Ácido Graxo Sintases/metabolismo
Ácidos Graxos/sangue
Feminino
Glucosefosfato Desidrogenase/genética
Glucosefosfato Desidrogenase/metabolismo
Lipogênese/efeitos dos fármacos
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Fenômenos Fisiológicos da Nutrição Materna
Gravidez
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Ratos
Ratos Wistar
Estearoil-CoA Dessaturase/genética
Estearoil-CoA Dessaturase/metabolismo
Proteína de Ligação a Elemento Regulador de Esterol 1/genética
Proteína de Ligação a Elemento Regulador de Esterol 1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats); 0 (Fatty Acids); 0 (Linoleic Acids, Conjugated); 0 (RNA, Messenger); 0 (Sterol Regulatory Element Binding Protein 1); 0 (Triglycerides); EC 1.1.1.49 (Glucosephosphate Dehydrogenase); EC 1.14.19.1 (Stearoyl-CoA Desaturase); EC 2.3.1.85 (Fatty Acid Synthases); EC 6.4.1.2 (Acetyl-CoA Carboxylase)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517003002


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[PMID]:29173205
[Au] Autor:Guimarães KSL; de Araújo EV; Aquino JS; Gadelha DA; Balarini CM; Costa-Silva JH; Magnani M; Vidal H; Braga VA; de Brito Alves JL
[Ad] Endereço:1Department of Nutrition,Health Sciences Center,Federal University of Paraiba,Joao Pessoa,58051-900,Brazil.
[Ti] Título:Effect of maternal dyslipidaemia on the cardiorespiratory physiology and biochemical parameters in male rat offspring.
[So] Source:Br J Nutr;118(11):930-941, 2017 Dec.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present study evaluated the effects of maternal dyslipidaemia on blood pressure (BP), cardiorespiratory physiology and biochemical parameters in male offspring. Wistar rat dams were fed either a control (CTL) or a dyslipidaemic (DLP) diet during pregnancy and lactation. After weaning, both CTL and DLP offspring received standard diet. On the 30th and 90th day of life, blood samples were collected for metabolic analyses. Direct measurements of BP, respiratory frequency (RF), tidal volume (VT) and ventilation (VE) under baseline condition, as well as during hypercapnia (7 % CO2) and hypoxia (KCN, 0·04 %), were recorded from awake 90-d-old male offspring. DLP dams exhibited raised serum levels of total cholesterol (TC) (4·0-fold), TAG (2·0-fold), VLDL+LDL (7·7-fold) and reduced HDL-cholesterol (2·4-fold), insulin resistance and hepatic steatosis at the end of lactation. At 30 d of age, the DLP offspring showed an increase in the serum levels of TC (P<0·05) and VLDL+LDL (P<0·05) in comparison with CTL offspring. At 90 d of age, DLP offspring exhibited higher mean arterial pressure (MAP, approximately 34 %). In the spectral analysis, the DLP group showed augmented low-frequency (LF) power and LF:high-frequency (HF) ratio when compared with CTL offspring. In addition, the DLP animals showed a larger delta variation in arterial pressure after administration of the ganglionic blocker (P=0·0003). We also found that cardiorespiratory response to hypercapnia and hypoxia was augmented in DLP offspring. In conclusion, the present data show that maternal dyslipidaemia alters cardiorespiratory physiology and may be a predisposing factor for hypertension at adulthood.
[Mh] Termos MeSH primário: Sistema Cardiovascular/fisiopatologia
Dislipidemias/sangue
Fenômenos Fisiológicos da Nutrição Materna
Efeitos Tardios da Exposição Pré-Natal
Sistema Respiratório/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Pressão Sanguínea
Colesterol/sangue
Fígado Gorduroso/fisiopatologia
Feminino
Hipertensão/fisiopatologia
Resistência à Insulina
Masculino
Gravidez
Ratos
Ratos Wistar
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Triglycerides); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517003014


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[PMID]:28747485
[Au] Autor:Al-Harbi AN; Khan KM; Rahman A
[Ad] Endereço:Department of Food Science and Nutrition, College of Life Sciences, and.
[Ti] Título:Developmental Vitamin D Deficiency Affects Spatial Learning in Wistar Rats.
[So] Source:J Nutr;147(9):1795-1805, 2017 09.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vitamin D deficiency is a global problem. Recent evidence suggests that vitamin D is involved in brain development and function. Vitamin D deficiency has been associated with poor cognitive function in adults, but the effect of developmental vitamin D deficiency (DVDD) on cognitive function and brain development in children has not been well established. We explored the effects of DVDD on cognitive functions and brain morphology of rat pups. Wistar rat pups born to control and vitamin D-deficient dams were divided into 4 groups: control (C), deficient during gestation (dG), deficient during lactation (dL), and deficient during gestation and lactation (dGL). Spatial learning and memory were assessed by the Morris water maze test at postnatal day (PND) 24 and PND 45. Cortical thickness at the level of the hippocampus was measured at PND 63, and synapses were counted in specified areas of the hippocampus at PND 32 and PND 63. Repeated-measures ANOVA revealed that at PND 24, learning (escape latency) was impaired (by 42%) in the dGL group, whereas at PND 45, both the dL and the dGL groups showed learning impairment (by 47% and 45%, respectively) compared with their respective C groups ( < 0.05). Short-term or long-term memory was largely unaffected by DVDD either at PND 24 or PND 45. Compared with the C group, all the DVDD groups had fewer synapses in the molecular layer of the hippocampus ( < 0.001). The synapse number decreased by 54% in the dGL group at PND 33 and by 70% in the dL and dGL groups at PND 63. All the DVDD groups at PND 63 showed a reduced cortical thickness (by 22%) compared with the C group ( < 0.05). These results suggest that a combined prenatal and postnatal DVDD for ≥6 wk in rat pups affects learning but not memory.
[Mh] Termos MeSH primário: Cognição
Hipocampo/crescimento & desenvolvimento
Transtornos de Aprendizagem/etiologia
Fenômenos Fisiológicos da Nutrição Materna
Memória
Aprendizagem Espacial
Deficiência de Vitamina D/complicações
[Mh] Termos MeSH secundário: Fenômenos Fisiológicos da Nutrição Animal
Animais
Animais Recém-Nascidos
Feminino
Lactação
Transtornos de Aprendizagem/sangue
Masculino
Aprendizagem em Labirinto
Gravidez
Efeitos Tardios da Exposição Pré-Natal
Ratos Wistar
Sinapses
Vitamina D/sangue
Deficiência de Vitamina D/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
1406-16-2 (Vitamin D)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.249953


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[PMID]:29056104
[Au] Autor:Cuthbert CE; Foster JE; Ramdath DD
[Ad] Endereço:1Department of Pre-Clinical Sciences, Faculty of Medical Sciences,The University of the West Indies,St. Augustine,Trinidad and Tobago, West Indies.
[Ti] Título:A maternal high-fat, high-sucrose diet alters insulin sensitivity and expression of insulin signalling and lipid metabolism genes and proteins in male rat offspring: effect of folic acid supplementation.
[So] Source:Br J Nutr;118(8):580-588, 2017 Oct.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A maternal high-fat, high-sucrose (HFS) diet alters offspring glucose and lipid homoeostasis through unknown mechanisms and may be modulated by folic acid. We investigated the effect of a maternal HFS diet on glucose homoeostasis, expression of genes and proteins associated with insulin signalling and lipid metabolism and the effect of prenatal folic acid supplementation (HFS/F) in male rat offspring. Pregnant Sprague-Dawley rats were randomly fed control (CON), HFS or HFS/F diets. Offspring were weaned on CON; at postnatal day 70, fasting plasma insulin and glucose and liver and skeletal muscle gene and protein expression were measured. Treatment effects were assessed by one-way ANOVA. Maternal HFS diet induced higher fasting glucose in offspring v. HFS/F (P=0·027) and down-regulation (P<0·05) of genes coding for v-Akt murine thymoma viral oncogene homolog 2, resistin and v-Raf-1 murine leukaemia viral oncogene homolog 1 (Raf1) in offspring skeletal muscle and acetyl-CoA carboxylase (Acaca), fatty acid synthase and phosphatidylinositol-4,5-biphosphate 3-kinase, catalytic subunit ß in offspring liver. Skeletal muscle neuropeptide Y and hepatic Kruppel-like factor 10 were up-regulated in HFS v. CON offspring (P<0·05). Compared with CON, Acaca and Raf1 protein expression levels were significantly lower in HFS offspring. Maternal HFS induced higher homoeostasis model of assessment index of insulin resistance v. CON (P=0·030) and HFS/F was associated with higher insulin (P=0·016) and lower glucose (P=0·025). Maternal HFS diet alters offspring insulin sensitivity and de novo hepatic lipogenesis via altered gene and protein expression, which appears to be potentiated by folate supplementation.
[Mh] Termos MeSH primário: Dieta Hiperlipídica
Resistência à Insulina
Insulina/sangue
Metabolismo dos Lipídeos
Fenômenos Fisiológicos da Nutrição Materna
[Mh] Termos MeSH secundário: Acetil-CoA Carboxilase/genética
Acetil-CoA Carboxilase/metabolismo
Animais
Animais Recém-Nascidos
Glicemia/metabolismo
Regulação para Baixo
Ácido Graxo Sintases/genética
Ácido Graxo Sintases/metabolismo
Feminino
Ácido Fólico/administração & dosagem
Fígado/metabolismo
Masculino
Fosfotransferases (Aceptor do Grupo Álcool)/genética
Fosfotransferases (Aceptor do Grupo Álcool)/metabolismo
Gravidez
Efeitos Tardios da Exposição Pré-Natal
Proteínas Proto-Oncogênicas c-akt/genética
Proteínas Proto-Oncogênicas c-akt/metabolismo
Proteínas Proto-Oncogênicas c-raf/genética
Proteínas Proto-Oncogênicas c-raf/metabolismo
Ratos
Ratos Sprague-Dawley
Resistina/genética
Resistina/metabolismo
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Insulin); 0 (Resistin); 0 (Retn protein, rat); 935E97BOY8 (Folic Acid); EC 2.3.1.85 (Fatty Acid Synthases); EC 2.7.1.- (Phosphotransferases (Alcohol Group Acceptor)); EC 2.7.1.- (phosphatidylinositol 4,5-biphosphate kinase); EC 2.7.11.1 (Akt2 protein, rat); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.1 (Proto-Oncogene Proteins c-raf); EC 2.7.11.1 (Raf1 protein, rat); EC 6.4.1.2 (Acetyl-CoA Carboxylase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171024
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517002501


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[PMID]:28957383
[Au] Autor:Vargas VE; Gurung S; Grant B; Hyatt K; Singleton K; Myers SM; Saunders D; Njoku C; Towner R; Myers DA
[Ad] Endereço:Departments of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America.
[Ti] Título:Gestational hypoxia disrupts the neonatal leptin surge and programs hyperphagia and obesity in male offspring in the Sprague-Dawley rat.
[So] Source:PLoS One;12(9):e0185272, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The effect of gestational hypoxia on the neonatal leptin surge, development of hypothalamic arcuate nuclei (ARH) projections and appetite that could contribute to the programming of offspring obesity is lacking. We examined the effect of 12% O2 from gestational days 15-19 in the Sprague-Dawley rat on post-weaning appetite, fat deposition by MRI, adipose tissue cytokine expression, the neonatal leptin surge, ARH response to exogenous leptin, and αMSH projections to the paraventricular nucleus (PVN) in response to a high fat (HFD) or control diet (CD) in male offspring. Normoxia (NMX) and Hypoxia (HPX) offspring exhibited increased food intake when fed a HFD from 5-8 weeks post-birth; HPX offspring on the CD had increased food intake from weeks 5-7 vs. NMX offspring on a CD. HPX offspring on a HFD remained hyperphagic through 23 weeks. Body weight were the same between offspring from HPX vs. NMX dams from 4-12 weeks of age fed a CD or HFD. By 14-23 weeks of age, HPX offspring fed the CD or HFD as well as male NMX offspring fed the HFD were heavier vs. NMX offspring fed the CD. HPX offspring fed a CD exhibited increased abdominal adiposity (MRI) that was amplified by a HFD. HPX offspring fed a HFD exhibited the highest abdominal fat cytokine expression. HPX male offspring had higher plasma leptin from postnatal day (PN) 6 through 14 vs. NMX pups. HPX offspring exhibited increased basal c-Fos labeled cells in the ARH vs. NMX pups on PN16. Leptin increased c-Fos staining in the ARH in NMX but not HPX offspring at PN16. HPX offspring had fewer αMSH fibers in the PVN vs. NMX offspring on PN16. In conclusion, gestational hypoxia impacts the developing ARH resulting in hyperphagia contributing to adult obesity on a control diet and exacerbated by a HFD.
[Mh] Termos MeSH primário: Hiperfagia/sangue
Hiperfagia/complicações
Hipóxia/sangue
Hipóxia/complicações
Leptina/sangue
Obesidade/sangue
Obesidade/complicações
[Mh] Termos MeSH secundário: Tecido Adiposo/metabolismo
Animais
Animais Recém-Nascidos
Ansiedade/sangue
Ansiedade/complicações
Núcleo Arqueado do Hipotálamo/metabolismo
Comportamento Animal
Dieta
Medo
Comportamento Alimentar
Feminino
Peso Fetal
Interleucina-1beta/genética
Interleucina-1beta/metabolismo
Interleucina-6/genética
Interleucina-6/metabolismo
Imagem por Ressonância Magnética
Masculino
Fenômenos Fisiológicos da Nutrição Materna
Aprendizagem em Labirinto
Atividade Motora
Gravidez
Ratos Sprague-Dawley
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/metabolismo
Água
Desmame
alfa-MSH/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-1beta); 0 (Interleukin-6); 0 (Leptin); 0 (Tumor Necrosis Factor-alpha); 059QF0KO0R (Water); 581-05-5 (alpha-MSH)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185272


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[PMID]:28911167
[Au] Autor:Seki Y; Suzuki M; Guo X; Glenn AS; Vuguin PM; Fiallo A; Du Q; Ko YA; Yu Y; Susztak K; Zheng D; Greally JM; Katz EB; Charron MJ
[Ad] Endereço:Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461.
[Ti] Título:In Utero Exposure to a High-Fat Diet Programs Hepatic Hypermethylation and Gene Dysregulation and Development of Metabolic Syndrome in Male Mice.
[So] Source:Endocrinology;158(9):2860-2872, 2017 Sep 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Exposure to a high-fat (HF) diet in utero is associated with increased incidence of cardiovascular disease, diabetes, and metabolic syndrome later in life. However, the molecular basis of this enhanced susceptibility for metabolic disease is poorly understood. Gene expression microarray and genome-wide DNA methylation analyses of mouse liver revealed that exposure to a maternal HF milieu activated genes of immune response, inflammation, and hepatic dysfunction. DNA methylation analysis revealed 3360 differentially methylated loci, most of which (76%) were hypermethylated and distributed preferentially to hotspots on chromosomes 4 [atherosclerosis susceptibility quantitative trait loci (QTLs) 1] and 18 (insulin-dependent susceptibility QTLs 21). Interestingly, we found six differentially methylated genes within these hotspot QTLs associated with metabolic disease that maintain altered gene expression into adulthood (Arhgef19, Epha2, Zbtb17/Miz-1, Camta1 downregulated; and Ccdc11 and Txnl4a upregulated). Most of the hypermethylated genes in these hotspots are associated with cardiovascular system development and function. There were 140 differentially methylated genes that showed a 1.5-fold increase or decrease in messenger RNA levels. Many of these genes play a role in cell signaling pathways associated with metabolic disease. Of these, metalloproteinase 9, whose dysregulation plays a key role in diabetes, obesity, and cardiovascular disease, was upregulated 1.75-fold and hypermethylated in the gene body. In summary, exposure to a maternal HF diet causes DNA hypermethylation, which is associated with long-term gene expression changes in the liver of exposed offspring, potentially contributing to programmed development of metabolic disease later in life.
[Mh] Termos MeSH primário: Metilação de DNA
Dieta Hiperlipídica
Regulação da Expressão Gênica
Fígado/metabolismo
Fenômenos Fisiológicos da Nutrição Materna
Síndrome Metabólica/etiologia
Efeitos Tardios da Exposição Pré-Natal/genética
Efeitos Tardios da Exposição Pré-Natal/metabolismo
[Mh] Termos MeSH secundário: Animais
Peso Corporal/genética
Feminino
Masculino
Síndrome Metabólica/genética
Síndrome Metabólica/metabolismo
Camundongos
Gravidez
Caracteres Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00334



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