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[PMID]:29447176
[Au] Autor:Svefors P; Selling KE; Shaheen R; Khan AI; Persson LÅ; Lindholm L
[Ad] Endereço:International Maternal and Child Health, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
[Ti] Título:Cost-effectiveness of prenatal food and micronutrient interventions on under-five mortality and stunting: Analysis of data from the MINIMat randomized trial, Bangladesh.
[So] Source:PLoS One;13(2):e0191260, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Nutrition interventions may have favourable as well as unfavourable effects. The Maternal and Infant Nutrition Interventions in Matlab (MINIMat), with early prenatal food and micronutrient supplementation, reduced infant mortality and were reported to be very cost-effective. However, the multiple micronutrients (MMS) supplement was associated with an increased risk of stunted growth in infancy and early childhood. This unfavourable outcome was not included in the previous cost-effectiveness analysis. The aim of this study is to evaluate whether the MINIMat interventions remain cost-effective in view of both favourable (decreased under-five-years mortality) and unfavourable (increased stunting) outcomes. METHOD: Pregnant women in rural Bangladesh, where food insecurity still is prevalent, were randomized to early (E) or usual (U) invitation to be given food supplementation and daily doses of 30 mg, or 60 mg iron with 400 µg of folic acid, or MMS with 15 micronutrients including 30 mg iron and 400 µg of folic acid. E reduced stunting at 4.5 years compared with U, MMS increased stunting at 4.5 years compared with Fe60, while the combination EMMS reduced infant mortality compared with UFe60. The outcome measure used was disability adjusted life years (DALYs), a measure of overall disease burden that combines years of life lost due to premature mortality (under five-year mortality) and years lived with disability (stunting). Incremental cost effectiveness ratios were calculated using cost data from already published studies. RESULTS: By incrementing UFe60 (standard practice) to EMMS, one DALY could be averted at a cost of US$24. CONCLUSION: When both favourable and unfavourable outcomes were included in the analysis, early prenatal food and multiple micronutrient interventions remained highly cost effective and seem to be meaningful from a public health perspective.
[Mh] Termos MeSH primário: Transtornos do Crescimento/etiologia
Fenômenos Fisiológicos da Nutrição do Lactente/economia
Micronutrientes/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Bangladesh/epidemiologia
Pré-Escolar
Análise Custo-Benefício/métodos
Suplementos Nutricionais
Feminino
Ácido Fólico
Abastecimento de Alimentos
Transtornos do Crescimento/tratamento farmacológico
Transtornos do Crescimento/mortalidade
Seres Humanos
Lactente
Mortalidade Infantil
Fenômenos Fisiológicos da Nutrição do Lactente/efeitos dos fármacos
Fenômenos Fisiológicos da Nutrição do Lactente/fisiologia
Recém-Nascido
Ferro
Masculino
Micronutrientes/administração & dosagem
Política Nutricional
Gravidez
Cuidado Pré-Natal
Fenômenos Fisiológicos da Nutrição Pré-Natal
Oligoelementos
Vitaminas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Micronutrients); 0 (Trace Elements); 0 (Vitamins); 935E97BOY8 (Folic Acid); E1UOL152H7 (Iron)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191260


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[PMID]:29265787
[Au] Autor:Bzikowska A; Czerwonogrodzka-Senczyna A; Riahi A; Weker H
[Ad] Endereço:Warsaw Medical University, Faculty of Health Science, Department of Clinical Dietetics, Warsaw, Poland
[Ti] Título:Nutritional value of daily food rations of overweight and normal weight pregnant women
[So] Source:Rocz Panstw Zakl Hig;68(4):375-379, 2017.
[Is] ISSN:0035-7715
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Background: Adequate nutrition and nutritional status during pregnancy are essential for mother's health and foetus development. Due to increased demands, pregnant women are vulnerable to inadequate nutritional status and paradoxically it may also affect overweight women Objective: The aim of the study was to evaluate energy and nutrients intake in the group of pregnant women in relation to nutritional standards and pre-pregnancy BMI Material and methods: The study included 90 women, during the third trimester of pregnancy, recruited from Warsaw antenatal classes. The anthropometric data gathered in the research were used to calculate BMI value before pregnancy. Pre-pregnancy BMI was categorised as: normal weight (BMI=18.5-24.9 kg/m2, n=47) and overweight (BMI ≥25.0 kg/m2, n=43). The assessment of women's nutrition was based on 3-days dietary record. Due to heterogeneous variances, differences between groups were assessed using Mann Whitney U test, p<0.05 was considered as significant Results: The mean intake of energy, protein, fat and carbohydrates in the overweight women were significantly higher than in healthy weight women (p<0.05). Most of the healthy weight women did not reach EAR standard for vitamin D (79.5%), whereas in overweight group it was 41.3% Conclusions: Despite the fact that intakes of energy and all nutrients were higher in overweight women than in normal weight ones, we observed that women in both groups had risk of insufficient supply of energy, iodine, potassium and vitamin D. For this reason, accurate nutritional assessment should be an integral part of obstetric care
[Mh] Termos MeSH primário: Dieta
Estado Nutricional
Valor Nutritivo
Terceiro Trimestre da Gravidez
Fenômenos Fisiológicos da Nutrição Pré-Natal
[Mh] Termos MeSH secundário: Índice de Massa Corporal
Registros de Dieta
Feminino
Seres Humanos
Peso Corporal Ideal
Avaliação Nutricional
Sobrepeso
Polônia
Gravidez
Cuidado Pré-Natal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


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[PMID]:29381305
[Au] Autor:Beketova NA; Sokolnikov AA; Kodentsova VM; Pereverzeva OG; Vrzhesinskaya OA; Kosheleva OV; Gmoshinskaya MV
[Ti] Título:[The vitamin status of pregnant women in Moscow: effect of multivitamin-mineral supplements].
[So] Source:Vopr Pitan;85(5):77-85, 2016.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Examination of the vitamin status of 102 pregnant women (19-41 years old) from Moscow (gestational age 6-38 weeks) in winter and spring 2015 has been conducted. The lack of vitamin B2 (blood serum level of riboflavin <5 ng/ml), D (25(OH)D level <30 ng/ml) and ß-carotene (<20 mg/dL) occurred in 49-66% of pregnant women. The percentage of persons with reduced serum levels of vitamin B6 (<4.8 mg/l), folic acid (<3 mg/l), vitamin A (<30 mg/dL), and E (<0.8 mg/dl) was insignificant and amounted 6-8%. All of the women had an adequate supply with vitamins C (>0.4 mg/dL) and B12 (>150 ng/L). The frequency of the combined deficiency of two vitamins was 29%, of three vitamins - 21%, four - 10%, five - 5%. Only 8% of women were sufficiently supplied with all 8 studied vitamins and ß-carotene. A positive correlation (p<0.001) between the concentration of vitamin E and gestation term occurred. ß-Carotene blood serum level raised with increasing gestation term in women receiving multivitamin-mineral supplements (VMS) and directly correlated (p<0.05) with vitamin E serum level. In 63 women who were not taking VMS, blood serum level of vitamins A, D, C, B2, B6, B12, folic acid and ß-carotene was lower, and the frequency of inadequate supply, on the contrary, was significantly higher, compared to 39 women receiving VMS. Blood serum concentration of vitamins C, A, D, B6 and folic acid in women who were not taking VMS was significantly reduced (p<0.05) with increasing gestation term, whereas in women consuming VMS vitamin blood serum level was maintained at a constant level. The data obtained demonstrate advisability of VMS intake during pregnancy to maintain vitamin status of pregnant women at a satisfactory level and to reduce the risk of birth defects in infants.
[Mh] Termos MeSH primário: Suplementos Nutricionais
Minerais/sangue
Gravidez/sangue
Fenômenos Fisiológicos da Nutrição Pré-Natal/fisiologia
Vitaminas/sangue
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Minerals); 0 (Vitamins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE


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[PMID]:29381016
[Au] Autor:Ancheva IA
[Ti] Título:[Functional food in pregnancy].
[So] Source:Vopr Pitan;85(4):22-8, 2016.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Mh] Termos MeSH primário: Alimentos Fortificados
Micronutrientes/administração & dosagem
Parto/fisiologia
Gravidez/fisiologia
Fenômenos Fisiológicos da Nutrição Pré-Natal/fisiologia
Probióticos/administração & dosagem
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Micronutrients)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE


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[PMID]:29378109
[Au] Autor:Kodentsova VM; Pogozheva AV; Gromova OA; Shikh EV
[Ti] Título:[Vitamin-mineral supplements in nutrition of adults].
[So] Source:Vopr Pitan;84(6):141-50, 2015.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The diet of population consisting of natural products is quite adequate and even excessive of energy consumption, but is not able to meet fully the need of organism in a number of micronutrients. Due to lack of sun exposure and long presence indoors endogenous synthesis of vitamin D in the skin by ultraviolet radiation does not provide the body's need for this vitamin. Intake of vitaminmineral supplements (VMS) is appropriate because combined deficiency of vitamins and minerals takes place in population. Prophylactic doses (equal to physiological needs) provide a diet completeness and reduce the risk of vitamin deficiency and its consequences. The high incidence of combined deficiency of vitamins among population and the existence of vitamin interactions are the basis for the application of the multivitamins. The simultaneous intake of vitamins is more physiological, their combination is more effective than a separate or isolated destination of each of them. Efficacy of the VMS has been shown in the treatment and prevention of some diseases. The main requirements for the VMS are full list of vitamins and minerals, the lack of which is detected most frequently, in doses covering the needs of organism. For the health of the pregnant woman and her unborn child preference should be given for complexes, containing DHA and/or probiotics along with vitamins. The principles of the selection of the composition and vitamin doses in the VMS for using patients suffering from various pathologies should be based on data on the patient's sufficiency with vitamins, the understanding of the role of vitamin deficiency in the pathogenesis of the disease, as well as on the composition of the diet and its modifications.
[Mh] Termos MeSH primário: Deficiência de Vitaminas/dietoterapia
Suplementos Nutricionais
Ingestão de Alimentos
Minerais/uso terapêutico
Fenômenos Fisiológicos da Nutrição Pré-Natal
Vitaminas/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Deficiência de Vitaminas/sangue
Feminino
Seres Humanos
Masculino
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Minerals); 0 (Vitamins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE


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[PMID]:29173199
[Au] Autor:See VHL; Mas E; Prescott SL; Beilin LJ; Burrows S; Barden AE; Huang RC; Mori TA
[Ad] Endereço:1School of Medicine,Royal Perth Hospital,The University of Western Australia,Perth, WA 6000,Australia.
[Ti] Título:Effects of prenatal n-3 fatty acid supplementation on offspring resolvins at birth and 12 years of age: a double-blind, randomised controlled clinical trial.
[So] Source:Br J Nutr;118(11):971-980, 2017 Dec.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Resolution of inflammation is an active process involving specialised pro-resolving mediators (SPM) generated from the n-3 fatty acids EPA and DHA. n-3 Fatty acid supplementation during pregnancy may provide an intervention strategy to modify these novel SPM. This study aimed to assess the effect of n-3 fatty acid supplementation in pregnancy on offspring SPM at birth and 12 years of age (12 years). In all, ninety-eight atopic pregnant women were randomised to 3·7 g daily n-3 fatty acids or a control (olive oil), from 20 weeks gestation until delivery. Blood was collected from the offspring at birth and at 12 years. Plasma SPM consisting of 18-hydroxyeicosapentaenoic acid (18-HEPE), E-series resolvins, 17-hydroxydocosahexaenoic acid (17-HDHA), D-series resolvins, 14-hydroxydocosahexaenoic acid (14-HDHA), 10 S,17S-dihydroxydocosahexaenoic acid, maresins and protectin 1, were measured by liquid chromatography-tandem MS. We identified the resolvins RvE1, RvE2, RvE3, RvD1, 17R-RvD1 and RvD2 for the first time in human cord blood. n-3 Fatty acids increased cord blood 18-HEPE (P<0·001) derived from EPA relative to the control group. DHA-derived 17-HDHA at birth was significantly increased in the n-3 fatty acid group relative to the controls (P=0·001), but other SPM were not different between the groups. n-3 Fatty acid supplementation during pregnancy was associated with an increase in SPM precursors in the offspring at birth but the effects were not sustained at 12 years. The presence of these SPM, particularly at birth, may have functions relevant in the newborn that remain to be established, which may be useful for future investigations.
[Mh] Termos MeSH primário: Suplementos Nutricionais
Ácidos Graxos Ômega-3/administração & dosagem
Ácidos Graxos Ômega-3/sangue
Fenômenos Fisiológicos da Nutrição Pré-Natal
[Mh] Termos MeSH secundário: Antígenos CD59/sangue
Criança
Pré-Escolar
Ácidos Docosa-Hexaenoicos/sangue
Método Duplo-Cego
Ácido Eicosapentaenoico/análogos & derivados
Ácido Eicosapentaenoico/sangue
Feminino
Seres Humanos
Lactente
Masculino
Azeite de Oliva/administração & dosagem
Gravidez
Cuidado Pré-Natal
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (18(R)-hydroxyeicosapentaenoic acid); 0 (5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid); 0 (CD59 Antigens); 0 (Fatty Acids, Omega-3); 0 (Olive Oil); 25167-62-8 (Docosahexaenoic Acids); 86360-66-9 (14-hydroxydocosahexaenoic acid); 90780-52-2 (17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid); AAN7QOV9EA (Eicosapentaenoic Acid)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517002914


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[PMID]:28978695
[Au] Autor:DeVilbiss EA; Magnusson C; Gardner RM; Rai D; Newschaffer CJ; Lyall K; Dalman C; Lee BK
[Ad] Endereço:Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, 3215 Market St, Philadelphia, PA, 19104, USA.
[Ti] Título:Antenatal nutritional supplementation and autism spectrum disorders in the Stockholm youth cohort: population based cohort study.
[So] Source:BMJ;359:j4273, 2017 Oct 04.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo: To determine whether nutritional supplementation during pregnancy is associated with a reduced risk of autism spectrum disorder (ASD) with and without intellectual disability in offspring. Observational prospective cohort study using multivariable logistic regression, sibling controls, and propensity score matching. Stockholm County, Sweden. 273 107 mother-child pairs identified through population registers. The study sample was restricted to children who were aged 4 to 15 years by the end of follow-up on 31 December 2011 and were born between 1996 and 2007. Multivitamin, iron, and folic acid supplement use was reported at the first antenatal visit. Diagnosis of ASD with and without intellectual disability in children determined from register data up to 31 December 2011. Prevalence of ASD with intellectual disability was 0.26% (158 cases in 61 934) in the maternal multivitamin use group and 0.48% (430 cases in 90 480) in the no nutritional supplementation use group. Maternal multivitamin use with or without additional iron or folic acid, or both was associated with lower odds of ASD with intellectual disability in the child compared with mothers who did not use multivitamins, iron, and folic acid (odds ratio 0.69, 95% confidence interval 0.57 to 0.84). Similar estimates were found in propensity score matched (0.68, 0.54 to 0.86) and sibling control (0.77, 0.52 to 1.15) matched analyses, though the confidence interval for the latter association included 1.0 and was therefore not statistically significant. There was no consistent evidence that either iron or folic acid use were inversely associated with ASD prevalence. Maternal multivitamin supplementation during pregnancy may be inversely associated with ASD with intellectual disability in offspring. Further scrutiny of maternal nutrition and its role in the cause of autism is recommended.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista
Ácido Fólico/administração & dosagem
Deficiência Intelectual
Ferro/administração & dosagem
Fenômenos Fisiológicos da Nutrição Pré-Natal/fisiologia
Vitaminas/administração & dosagem
[Mh] Termos MeSH secundário: Adolescente
Transtorno do Espectro Autista/epidemiologia
Transtorno do Espectro Autista/etiologia
Transtorno do Espectro Autista/prevenção & controle
Transtorno do Espectro Autista/psicologia
Criança
Pré-Escolar
Suplementos Nutricionais
Feminino
Seres Humanos
Deficiência Intelectual/epidemiologia
Deficiência Intelectual/etiologia
Deficiência Intelectual/fisiopatologia
Masculino
Apoio Nutricional/métodos
Avaliação de Resultados (Cuidados de Saúde)
Gravidez
Resultado da Gravidez
Prevalência
Estatística como Assunto
Suécia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Vitamins); 935E97BOY8 (Folic Acid); E1UOL152H7 (Iron)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171028
[Lr] Data última revisão:
171028
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j4273


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[PMID]:28768834
[Au] Autor:Batistel F; Alharthi AS; Wang L; Parys C; Pan YX; Cardoso FC; Loor JJ
[Ad] Endereço:Division of Nutritional Sciences, Departments of Animal Sciences and.
[Ti] Título:Placentome Nutrient Transporters and Mammalian Target of Rapamycin Signaling Proteins Are Altered by the Methionine Supply during Late Gestation in Dairy Cows and Are Associated with Newborn Birth Weight.
[So] Source:J Nutr;147(9):1640-1647, 2017 Sep.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To our knowledge, most research demonstrating a link between maternal nutrition and both fetal growth and offspring development after birth has been performed with nonruminants. Whether such relationships exist in large ruminants is largely unknown. We aimed to investigate whether increasing the methionine supply during late pregnancy would alter uteroplacental tissue nutrient transporters and mammalian target of rapamycin (mTOR) and their relation with newborn body weight. Multiparous Holstein cows were used in a randomized complete block design experiment. During the last 28 d of pregnancy, cows were fed a control diet or the control diet plus ethylcellulose rumen-protected methionine (0.9 g/kg dry matter intake) (Mepron; Evonik Nutrition & Care GmbH) to achieve a 2.8:1 ratio of lysine to methionine in the metabolizable protein reaching the small intestine. We collected placentome samples at parturition and used them to assess mRNA and protein expression and the phosphorylation status of mTOR pathway proteins. Newborn body weight was greater in the methionine group than in the control group (44.1 kg and 41.8 kg, respectively; ≤ 0.05). Increasing the methionine supply also resulted in greater feed intake (15.8 kg/d and 14.6 kg/d), plasma methionine (11.9 µM and 15.3 µM), and plasma insulin (1.16 µg/L and 0.81 µg/L) in cows during late pregnancy. As a result, mRNA expression of genes involved in neutral amino acid transport [solute carrier (SLC) family members , , , and ], glucose transport [ , , and ], and the mTOR pathway [mechanistic target of rapamycin and ribosomal protein S6 kinase B1] were upregulated ( ≤ 0.07) in methionine-supplemented cows. Among 6 proteins in the mTOR pathway, increasing the methionine supply led to greater ( ≤ 0.09) protein expression of α serine-threonine kinase (AKT), phosphorylated (p)-AKT, p-eukaryotic elongation factor 2, and the p-mTOR:mTOR ratio. Supplemental methionine during late gestation increases feed intake and newborn body weight in dairy cows, and this effect may be mediated by alterations in the uteroplacental transport of nondispensable and dispensable amino acids and glucose at least in part through changes in gene transcription and mTOR signaling.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos da Nutrição Animal
Peso ao Nascer/efeitos dos fármacos
Metionina/farmacologia
Placenta/metabolismo
Fenômenos Fisiológicos da Nutrição Pré-Natal
Proteínas Carreadoras de Solutos/metabolismo
Serina-Treonina Quinases TOR/metabolismo
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Bovinos
Dieta/veterinária
Suplementos Nutricionais
Ingestão de Energia/efeitos dos fármacos
Feminino
Idade Gestacional
Glucose/metabolismo
Insulina/sangue
Intestino Delgado
Lisina/administração & dosagem
Metionina/administração & dosagem
Metionina/sangue
Gravidez
RNA Mensageiro/metabolismo
Distribuição Aleatória
Proteínas Carreadoras de Solutos/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insulin); 0 (RNA, Messenger); 0 (Solute Carrier Proteins); AE28F7PNPL (Methionine); EC 2.7.1.1 (TOR Serine-Threonine Kinases); IY9XDZ35W2 (Glucose); K3Z4F929H6 (Lysine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.251876


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[PMID]:28724645
[Au] Autor:Valera-Gran D; Navarrete-Muñoz EM; Garcia de la Hera M; Fernández-Somoano A; Tardón A; Ibarluzea J; Balluerka N; Murcia M; González-Safont L; Romaguera D; Julvez J; Vioque J; INMA Project
[Ad] Endereço:Department of Public Health, History of Medicine, and Gynecology, University Miguel Hernández, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante, Spain.
[Ti] Título:Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4-5 y of age: the prospective birth cohort Infancia y Medio Ambiente (INMA) study.
[So] Source:Am J Clin Nutr;106(3):878-887, 2017 Sep.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The benefits of the use of folic acid supplements (FASs) during the periconception period to prevent neural tube defects and to ensure normal brain development in offspring are well known. There is concern, however, about the long-term effects of the maternal use of high dosages of FASs that exceed the Tolerable Upper Intake Level (UL) (≥1000 µg/d) on child neurocognitive outcomes. The objective of the study was to examine the association between the use of high dosages of FASs during pregnancy and child neuropsychological development at ages 4-5 y. The multicenter prospective mother-child cohort study, the Infancia y Medio Ambiente (INMA) Project, was conducted in 4 regions of Spain: Asturias, Sabadell, Gipuzkoa, and Valencia. Pregnant women were recruited between 2003 and 2008. Data on 1682 mother-child pairs were included in the final analyses. The pregnant women completed an interviewer-administered questionnaire that was validated to estimate typical dietary folate intake and the use of FASs at 10-13 and 28-32 wk of gestation. Neuropsychological development scores at 4-5 y of age were estimated with the use of the McCarthy Scales of Children's Abilities. Multiple linear regression and meta-analysis were used to obtain combined-effect estimates. During the periconception period, one-third of the women ( = 502) took FAS dosages ≥1000 µg/d. The use of FAS dosages ≥1000 µg/d in this period was negatively associated with several neuropsychological outcomes scores in children: global verbal (ß = -2.49; 95% CI: -4.71, -0.27), verbal memory (ß = -3.59; 95% CI: -6.95, -0.23), cognitive function of posterior cortex (ß = -2.31; 95% CI: -4.45, -0.18), and cognitive function of left posterior cortex (ß = -3.26; 95% CI: -5.51, -1.01). The use of FAS dosages exceeding the UL (≥1000 µg/d) during the periconception period was associated with lower levels of cognitive development in children aged 4-5 y. The use of FAS dosages ≥1000 µg/d during pregnancy should be monitored and prevented as much as possible, unless medically prescribed.
[Mh] Termos MeSH primário: Desenvolvimento Infantil/efeitos dos fármacos
Cognição/efeitos dos fármacos
Suplementos Nutricionais/efeitos adversos
Ácido Fólico/efeitos adversos
Memória/efeitos dos fármacos
Efeitos Tardios da Exposição Pré-Natal
Fenômenos Fisiológicos da Nutrição Pré-Natal
[Mh] Termos MeSH secundário: Adulto
Encéfalo/efeitos dos fármacos
Pré-Escolar
Dieta
Inquéritos sobre Dietas
Feminino
Ácido Fólico/administração & dosagem
Seres Humanos
Masculino
Gravidez
Estudos Prospectivos
Espanha
Complexo Vitamínico B/administração & dosagem
Complexo Vitamínico B/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
12001-76-2 (Vitamin B Complex); 935E97BOY8 (Folic Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.117.152769


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[PMID]:28679553
[Au] Autor:Maslova E; Hansen S; Grunnet LG; Strøm M; Bjerregaard AA; Hjort L; Kampmann FB; Madsen CM; Baun Thuesen AC; Bech BH; Halldorsson TI; Vaag AA; Olsen SF
[Ad] Endereço:Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark; kmv@ssi.dk.
[Ti] Título:Maternal protein intake in pregnancy and offspring metabolic health at age 9-16 y: results from a Danish cohort of gestational diabetes mellitus pregnancies and controls.
[So] Source:Am J Clin Nutr;106(2):623-636, 2017 Aug.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent years have seen strong tendencies toward high-protein diets. However, the implications of higher protein intake, especially during developmentally sensitive periods, are poorly understood. Conversely, evidence on the long-term developmental consequences of low protein intake in free-living populations remains limited. We examined the association of protein intake in pregnancy with offspring metabolic health at age 9-16 y in a longitudinal cohort that oversampled pregnancies with gestational diabetes mellitus (GDM). Six hundred eight women with an index pregnancy affected by gestational diabetes mellitus and 626 controls enrolled in the Danish National Birth Cohort were used for the analysis. Protein (total, animal, vegetable) intake was assessed by using a food-frequency questionnaire in gestational week 25. The offspring underwent a clinical examination including fasting blood samples and a dual-energy X-ray absorptiometry scan (subset of 650) from which metabolic outcomes were derived. Multivariable analyses were conducted applying a 1:1 substitution of carbohydrates for protein. The mean ± SD protein intake in pregnancy was 93 ± 15 g/d (16% ± 3% of energy) in GDM-exposed women and 90 ± 14 g/d (16% ± 2% of energy) in control women. There were overall no associations between maternal protein intake and offspring fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR). We found that maternal total protein intake was associated with a tendency for a higher abdominal fat mass percentage (quartile 4 compared with quartile 1: 0.40 SD; 95% CI: -0.03, 0.83 SD; = 0.07) in GDM-exposed offspring and a tendency for a higher total fat mass percentage among male offspring (quartile 4 compared with quartile 1: 0.33 SD; 95% CI: -0.01, 0.66 SD; = 0.06), but a small sample size may have compromised the precision of the effect estimates. GDM-exposed offspring of mothers with a protein intake in the lowest decile (≤12.5% of energy compared with >12.5% of energy) had lower fasting insulin (ratio of geometric means: 0.82; 95% CI: 0.68, 0.99; = 0.04) and a tendency toward lower HOMA-IR (ratio of geometric means: 0.82; 95% CI: 0.66, 1.02; = 0.07), but there was no evidence of associations with body composition. Male offspring seemed to derive a similar benefit from a maternal low protein intake as did GDM-exposed offspring. Overall, our results provide little support for an association of maternal protein intake in pregnancy with measures of offspring metabolic health. Further studies in larger cohorts are needed to determine whether low maternal protein intake in pregnancy may improve glucose homeostasis in GDM-exposed and male offspring.
[Mh] Termos MeSH primário: Tecido Adiposo/metabolismo
Diabetes Gestacional
Dieta
Proteínas na Dieta/administração & dosagem
Comportamento Alimentar
Insulina/sangue
Efeitos Tardios da Exposição Pré-Natal
[Mh] Termos MeSH secundário: Gordura Abdominal/metabolismo
Adolescente
Adulto
Glicemia/metabolismo
Composição Corporal
Criança
Dinamarca
Inquéritos sobre Dietas
Proteínas na Dieta/farmacologia
Feminino
Seres Humanos
Resistência à Insulina
Estudos Longitudinais
Masculino
Mães
Gravidez
Fenômenos Fisiológicos da Nutrição Pré-Natal
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Dietary Proteins); 0 (Insulin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.115.128637



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