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[PMID]:28747487
[Au] Autor:Arikawa AY; Samavat H; Gross M; Kurzer MS
[Ad] Endereço:Department of Nutrition and Dietetics, University of North Florida, Jacksonville, FL; andrea.arikawa@unf.edu.
[Ti] Título:Plasma F -isoprostanes Are Positively Associated with Glycemic Load, but Inversely Associated with Dietary Polyunsaturated Fatty Acids and Insoluble Fiber in Postmenopausal Women.
[So] Source:J Nutr;147(9):1693-1699, 2017 09.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dietary factors, such as antioxidant nutrients, contribute significantly to the maintenance of an appropriate balance between antioxidant defense and free radical production in the body. The objective of this study was to examine the relation between oxidative stress as assessed by plasma F -isoprostane (IsoP) concentration, glycemic load (GL), glycemic index (GI), intake of antioxidant nutrients, dietary fiber, and polyunsaturated fatty acids (PUFAs). This study was a cross-sectional secondary analysis of baseline data collected from a random sample of 269 postmenopausal women participating in the Minnesota Green Tea Trial. GL, GI, and dietary variables were calculated from the diet history questionnaire. Subjects filled out surveys about the use of anti-inflammatory drugs and physical activity. Plasma IsoP concentration was assessed by GC-mass spectrometry. IsoP concentrations were compared across quartiles of GL, GI, insoluble fiber, PUFAs, and antioxidant nutrients with the use of linear regression. Antioxidant supplement intake, including zinc, copper, vitamin C and vitamin E, was reported by >60% of the participants. Mean intake of PUFAs was 12.5 g. Mean plasma IsoP concentrations increased from 34 to 36.7 pg/mL in the lowest quartiles of GL and GI, respectively, to 45.2 and 41.6 pg/mL, respectively, in the highest quartiles ( -trend = 0.0014 for GL and -trend = 0.0379 for GI), whereas mean IsoP concentrations decreased from 41.8 pg/mL in the lowest quartile of PUFAs to 34.9 pg/mL in the highest quartile ( -trend = 0.0416). Similarly, mean IsoP concentrations decreased from 44.4 pg/mL in the lowest quartile of insoluble fiber to 36 pg/mL in the highest quartile ( -trend = 0.0243) after adjustment for potential confounders. We concluded that dietary PUFAs and insoluble fiber are inversely associated with oxidative stress whereas GL and GI are positively associated with oxidative stress in postmenopausal women. This trial was registered at clinicaltrials.gov as NCT00917735.
[Mh] Termos MeSH primário: Dieta
Fibras na Dieta/farmacologia
F2-Isoprostanos/sangue
Ácidos Graxos Insaturados/farmacologia
Índice Glicêmico
Carga Glicêmica
Estresse Oxidativo
[Mh] Termos MeSH secundário: Antioxidantes/administração & dosagem
Estudos Transversais
Gorduras Insaturadas na Dieta/farmacologia
Feminino
Seres Humanos
Meia-Idade
Pós-Menopausa
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Antioxidants); 0 (Dietary Fats, Unsaturated); 0 (Dietary Fiber); 0 (F2-Isoprostanes); 0 (Fatty Acids, Unsaturated)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180124
[Lr] Data última revisão:
180124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.254631


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[PMID]:28968893
[Au] Autor:Zhu J; Tu H; Matin SF; Tannir NM; Wood CG; Wu X
[Ad] Endereço:Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
[Ti] Título:Glycemic index, glycemic load and carbohydrate intake in association with risk of renal cell carcinoma.
[So] Source:Carcinogenesis;38(11):1129-1135, 2017 Oct 26.
[Is] ISSN:1460-2180
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Carbohydrate intake affects postprandial glucose levels and insulin response, which plays a role in carcinogenesis. The relationship between carbohydrate intake, dietary glycemic index (GI) and glycemic load (GL), and risk of renal cell carcinoma (RCC) remains unclear. We conducted a case-control study including 854 patients with newly diagnosed RCC (cases) and 1255 healthy participants (controls) recruited since 2002. GI, GL and carbohydrate intake were obtained via a validated food frequency questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable logistic regression, adjusting for potential confounders. We found that higher GI was significantly associated with RCC risk with an OR of 1.32 (95% CI, 0.99-1.74; Ptrend = 0.026) (the highest versus the lowest quartiles). We also observed an inverse association between fiber intake and RCC risk with OR of 0.70 (95% CI = 0.50-0.99) as well as between starch intake and risk of RCC with OR of 0.65 (95% CI = 0.49-0.87). Individuals with a high-GI diet and hypertension or high body mass index (BMI) had a 2.7 times (OR = 2.67, 95% CI = 1.96-3.64) and two times (OR = 1.95, 95% CI = 1.29-2.92) higher RCC risk, respectively, than those without these factors. Our findings suggest that a high-GI diet is associated with an increased risk of RCC, whereas increased fiber and starch intakes appear to be associated with a decreased risk of RCC. We found that reducing GI levels and increasing fiber intake could be a dietary strategy to decrease RCC risk, especially for individuals with hypertension or high BMI.
[Mh] Termos MeSH primário: Carboidratos/administração & dosagem
Carboidratos/efeitos adversos
Carcinoma de Células Renais/etiologia
Dieta/efeitos adversos
Índice Glicêmico/fisiologia
Carga Glicêmica/fisiologia
[Mh] Termos MeSH secundário: Índice de Massa Corporal
Estudos de Casos e Controles
Fibras na Dieta/administração & dosagem
Comportamento Alimentar/fisiologia
Feminino
Seres Humanos
Hipertensão/etiologia
Insulina
Modelos Logísticos
Masculino
Meia-Idade
Razão de Chances
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbohydrates); 0 (Dietary Fiber); 0 (Insulin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE
[do] DOI:10.1093/carcin/bgx083


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[PMID]:28679551
[Au] Autor:Hjorth MF; Ritz C; Blaak EE; Saris WH; Langin D; Poulsen SK; Larsen TM; Sørensen TI; Zohar Y; Astrup A
[Ad] Endereço:Department of Nutrition, Exercise and Sports, Faculty of Sciences, madsfiil@nexs.ku.dk.
[Ti] Título:Pretreatment fasting plasma glucose and insulin modify dietary weight loss success: results from 3 randomized clinical trials.
[So] Source:Am J Clin Nutr;106(2):499-505, 2017 Aug.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Which diet is optimal for weight loss and maintenance remains controversial and implies that no diet fits all patients. We studied concentrations of fasting plasma glucose (FPG) and fasting insulin (FI) as prognostic markers for successful weight loss and maintenance through diets with different glycemic loads or different fiber and whole-grain content, assessed in 3 randomized trials of overweight participants. After an 8-wk weight loss, participants in the DiOGenes (Diet, Obesity, and Genes) trial consumed ad libitum for 26 wk a diet with either a high or a low glycemic load. Participants in the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) Supermarket intervention (SHOPUS) trial consumed ad libitum for 26 wk the New Nordic Diet, which is high in fiber and whole grains, or a control diet. Participants in the NUGENOB (Nutrient-Gene Interactions in Human Obesity) trial consumed a hypocaloric low-fat and high-carbohydrate or a high-fat and low-carbohydrate diet for 10 wk. On the basis of FPG before treatment, participants were categorized as normoglycemic (FPG <5.6 mmol/L), prediabetic (FPG 5.6-6.9 mmol/L), or diabetic (FPG ≥7.0 mmol/L). Modifications of the dietary effects of FPG and FI before treatment were examined with linear mixed models. In the DiOGenes trial, prediabetic individuals regained a mean of 5.83 kg (95% CI: 3.34, 8.32 kg; < 0.001) more on the high- than on the low-glycemic load diet, whereas normoglycemic individuals regained a mean of 1.44 kg (95% CI: 0.48, 2.41 kg; = 0.003) more [mean group difference: 4.39 kg (95% CI: 1.76, 7.02 kg); = 0.001]. In SHOPUS, prediabetic individuals lost a mean of 6.04 kg (95% CI: 4.05, 8.02 kg; < 0.001) more on the New Nordic Diet than on the control diet, whereas normoglycemic individuals lost a mean of 2.20 kg (95% CI: 1.21, 3.18 kg; < 0.001) more [mean group difference: 3.84 kg (95% CI: 1.62, 6.06 kg); = 0.001]. In NUGENOB, diabetic individuals lost a mean of 2.04 kg (95% CI: -0.20, 4.28 kg; = 0.07) more on the high-fat and low-carbohydrate diet than on the low-fat and high-carbohydrate diet, whereas normoglycemic individuals lost a mean of 0.43 kg (95% CI: 0.03, 0.83 kg; = 0.03) more on the low-fat and high-carbohydrate diet [mean group difference: 2.47 kg (95% CI: 0.20, 4.75 kg); = 0.03]. The addition of FI strengthened these associations. Elevated FPG before treatment indicates success with dietary weight loss and maintenance among overweight patients consuming diets with a low glycemic load or with large amounts of fiber and whole grains. These trials were registered at clinicaltrials.gov as NCT00390637 (DiOGenes) and NCT01195610 (SHOPUS), and at ISRNCT.com as ISRCTN25867281 (NUGENOB).
[Mh] Termos MeSH primário: Glicemia/metabolismo
Manutenção do Peso Corporal/fisiologia
Diabetes Mellitus/sangue
Comportamento Alimentar
Insulina/sangue
Obesidade/dietoterapia
Perda de Peso/fisiologia
[Mh] Termos MeSH secundário: Adulto
Dieta Redutora
Fibras na Dieta
Ingestão de Energia
Feminino
Carga Glicêmica
Seres Humanos
Masculino
Meia-Idade
Obesidade/sangue
Obesidade/complicações
Grãos Integrais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Dietary Fiber); 0 (Insulin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.117.155200


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[PMID]:28660846
[Au] Autor:Makarem N; Bandera EV; Lin Y; Jacques PF; Hayes RB; Parekh N
[Ad] Endereço:1Department of Medicine,Columbia University Medical Center,51 Audubon Avenue,Suite 501,New York,NY 10032,USA.
[Ti] Título:Carbohydrate nutrition and risk of adiposity-related cancers: results from the Framingham Offspring cohort (1991-2013).
[So] Source:Br J Nutr;117(11):1603-1614, 2017 Jun.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Higher carbohydrate intake, glycaemic index (GI), and glycaemic load (GL) are hypothesised to increase cancer risk through metabolic dysregulation of the glucose-insulin axis and adiposity-related mechanisms, but epidemiological evidence is inconsistent. This prospective cohort study investigates carbohydrate quantity and quality in relation to risk of adiposity-related cancers, which represent the most commonly diagnosed preventable cancers in the USA. In exploratory analyses, associations with three site-specific cancers: breast, prostate and colorectal cancers were also examined. The study sample consisted of 3184 adults from the Framingham Offspring cohort. Dietary data were collected in 1991-1995 using a FFQ along with lifestyle and medical information. From 1991 to 2013, 565 incident adiposity-related cancers, including 124 breast, 157 prostate and sixty-eight colorectal cancers, were identified. Cox proportional hazards models were used to evaluate the role of carbohydrate nutrition in cancer risk. GI and GL were not associated with risk of adiposity-related cancers or any of the site-specific cancers. Total carbohydrate intake was not associated with risk of adiposity-related cancers combined or prostate and colorectal cancers. However, carbohydrate consumption in the highest v. lowest quintile was associated with 41 % lower breast cancer risk (hazard ratio (HR) 0·59; 95 % CI 0·36, 0·97). High-, medium- and low-GI foods were not associated with risk of adiposity-related cancers or prostate and colorectal cancers. In exploratory analyses, low-GI foods, were associated with 49 % lower breast cancer risk (HR 0·51; 95 % CI 0·32, 0·83). In this cohort of Caucasian American adults, associations between carbohydrate nutrition and cancer varied by cancer site. Healthier low-GI carbohydrate foods may prevent adiposity-related cancers among women, but these findings require confirmation in a larger sample.
[Mh] Termos MeSH primário: Neoplasias da Mama/etiologia
Neoplasias Colorretais/etiologia
Dieta
Carboidratos da Dieta/efeitos adversos
Comportamento Alimentar
Obesidade/complicações
Neoplasias da Próstata/etiologia
[Mh] Termos MeSH secundário: Adiposidade
Glicemia/metabolismo
Neoplasias da Mama/sangue
Neoplasias Colorretais/sangue
Carboidratos da Dieta/sangue
Ingestão de Energia
Grupo com Ancestrais do Continente Europeu
Feminino
Índice Glicêmico
Carga Glicêmica
Seres Humanos
Insulina/sangue
Masculino
Meia-Idade
Obesidade/sangue
Modelos de Riscos Proporcionais
Estudos Prospectivos
Neoplasias da Próstata/sangue
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Dietary Carbohydrates); 0 (Insulin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517001489


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[PMID]:28606553
[Au] Autor:Burris J; Rietkerk W; Shikany JM; Woolf K
[Ti] Título:Differences in Dietary Glycemic Load and Hormones in New York City Adults with No and Moderate/Severe Acne.
[So] Source:J Acad Nutr Diet;117(9):1375-1383, 2017 Sep.
[Is] ISSN:2212-2672
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Glycemic index (GI) and glycemic load (GL) may be implicated in acne pathogenesis. OBJECTIVE: This cross-sectional study examined differences between GI/GL and biological factors associated with acne among adults with and without moderate/severe acne. Secondary objectives included examining differences between food-aggravated acne beliefs and acne-specific quality of life among adults with and without moderate/severe acne. DESIGN: As part of a cross-sectional study, participants completed a 5-day food record; blood draw to measure biological factors associated with acne (ie, glucose, insulin, insulin-like growth factor-1, insulin-like growth factor binding protein-3, and sex hormone-binding globulin concentrations); body composition assessment; and questionnaire to evaluate food-aggravated acne beliefs and acne-specific quality of life. Food records were analyzed using Nutrition Data Services for Research. PARTICIPANTS: Sixty-four participants (no acne, n=32; moderate/severe acne, n=32) from New York City, NY, were included in this study. STATISTICAL ANALYSIS: Independent sample t tests and Mann-Whitney tests examined differences in anthropometric measurements, dietary intakes, biological factors associated with acne, insulin resistance, and acne-specific quality of life between acne groups. A χ test for independence assessed differences in food-aggravated acne beliefs between acne groups. RESULTS: Participants with moderate/severe acne consumed greater total carbohydrate (P=0.003), available carbohydrate (P<0.001), percent energy from carbohydrate (P<0.001), and GL (P<0.001) compared to participants without acne. Participants with moderate/severe acne had greater insulin (P=0.002) and insulin-like growth factor-1 (P=0.009) concentrations, greater insulin resistance (P=0.001), and lower sex hormone-binding globulin (P=0.015) concentrations compared to participants without acne. Although there were no differences between groups, 61% of participants reported food-influenced acne. Participants with moderate/severe acne reported a lower quality of life compared to participants without acne (P<0.001). CONCLUSIONS: The results from this cross-sectional study suggest a relationship between dietary carbohydrate, including GL, and acne. Future research is necessary to determine the effect of medical nutrition therapy on biological factors associated with acne and acne severity.
[Mh] Termos MeSH primário: Acne Vulgar/sangue
Dieta/efeitos adversos
Carboidratos da Dieta/efeitos adversos
Carga Glicêmica
[Mh] Termos MeSH secundário: Acne Vulgar/etiologia
Acne Vulgar/psicologia
Adulto
Antropometria
Glicemia/análise
Distribuição de Qui-Quadrado
Estudos Transversais
Registros de Dieta
Ingestão de Alimentos
Feminino
Seres Humanos
Insulina/sangue
Resistência à Insulina
Proteína 1 de Ligação a Fator de Crescimento Semelhante à Insulina/sangue
Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina/sangue
Masculino
Cidade de Nova Iorque
Qualidade de Vida
Globulina de Ligação a Hormônio Sexual/análise
Estatísticas não Paramétricas
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Dietary Carbohydrates); 0 (Insulin); 0 (Insulin-Like Growth Factor Binding Protein 1); 0 (Insulin-Like Growth Factor Binding Protein 3); 0 (Sex Hormone-Binding Globulin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE


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[PMID]:28566308
[Au] Autor:Kusnadi DTL; Barclay AW; Brand-Miller JC; Louie JCY
[Ad] Endereço:Charles Perkins Centre and School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Camperdown, New South Wales, Australia.
[Ti] Título:Changes in dietary glycemic index and glycemic load in Australian adults from 1995 to 2012.
[So] Source:Am J Clin Nutr;106(1):189-198, 2017 Jul.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Australians have used the glycemic index (GI) since 1995; however, there are no data on changes in carbohydrate quality over time. The aim was to compare average dietary GI and glycemic load (GL), and contributing carbohydrate foods, in the 2 most recent national dietary surveys. Dietary data from adult participants of national nutrition surveys conducted in 1995 (the 1995 Australian National Nutrition Survey; = 8703) and 2012 (the 2011-2012 National Nutrition and Physical Activity Survey; = 6278), collected by a single 24-h recall, were analyzed. The differences in mean dietary GI and GL between surveys were compared by using 1-factor ANOVA. The main sources of dietary GL in the 2 surveys were also assessed. Multiple linear regression was performed to examine the contributions of the food groups to interindividual variations in dietary GI and GL. Overall, dietary GI and GL decreased by 5% and 12%, respectively, from 1995 to 2012 (GI on glucose standard: 56.5 ± 6.2 compared with 53.9 ± 6.8, respectively; GL: 153.3 ± 62.1 compared with 135.4 ± 58.5, respectively; both < 0.001). Breads were the main contributor to GL at both time points. Potatoes and sweetened beverages contributed less, whereas cereal-based dishes contributed more in 2012 than in 1995. The top 20 GL-contributing food groups explained less interindividual variation in dietary GI ( : 0.376 compared with 0.290) and GL ( : 0.825 compared with 0.770) in 2012 than in 1995. Although the average dietary GI and GL declined between 1995 and 2012, trends in specific carbohydrate foods suggest that Australians are avoiding potatoes and sugary beverages in favor of a greater variety of carbohydrate foods, particularly cereal products.
[Mh] Termos MeSH primário: Dieta/tendências
Carboidratos da Dieta
Comportamento Alimentar
Índice Glicêmico
Carga Glicêmica
[Mh] Termos MeSH secundário: Adulto
Idoso
Austrália
Bebidas
Glicemia/metabolismo
Carboidratos da Dieta/administração & dosagem
Carboidratos da Dieta/sangue
Grãos Comestíveis
Feminino
Seres Humanos
Masculino
Meia-Idade
Inquéritos Nutricionais
Solanum tuberosum
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Dietary Carbohydrates)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.150516


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[PMID]:28532533
[Au] Autor:Al Dhaheri AS; Henry CJK; Mohamad MN; Ohuma EO; Ismail LC; Al Meqbaali FT; Jarrar AH
[Ad] Endereço:1Nutrition and Health Department,College of Food and Agriculture,United Arab Emirates University,Al Ain,PO Box 15551,United Arab Emirates.
[Ti] Título:Glycaemic index and glycaemic load values of commonly consumed foods in the United Arab Emirates.
[So] Source:Br J Nutr;117(8):1110-1117, 2017 Apr.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Glycaemic index (GI) and glycaemic load (GL) values of some commonly consumed foods in the United Arab Emirates were determined with an aim of adding these values to the existing international table of GI and GL values. In all, eighteen test foods categorised into breads (n 5), entrée dishes (n 3), main dishes (n 5) and sweet dishes (n 5) were tested. For each test food, at least fifteen healthy participants consumed 25 or 50 g available carbohydrate portions of a reference food (glucose), which was tested three times, and a test food after an overnight fast, was tested once, on separate occasions. Capillary blood samples were obtained by finger-prick and blood glucose was measured using clinical chemistry analyser. A fasting blood sample was obtained at baseline and before consumption of test foods. Additional blood samples were obtained at 15, 30, 45, 60, 90 and 120 min after the consumption of each test food. The GI value of each test food was calculated as the percentage of the incremental area under the blood glucose curve (IAUC) for the test food of each participant divided by the average IAUC for the reference food of the same participant. The GI values of tested foods ranged from low (55 or less) to high (70 or more). The GI values of various breads and rice-containing dishes were comparable with previously published values. This study provides GI and GL values of previously untested traditional Emirati foods which could provide a useful guide on dietary recommendations for the Emirati population.
[Mh] Termos MeSH primário: Alimentos/classificação
Índice Glicêmico
Carga Glicêmica
[Mh] Termos MeSH secundário: Adulto
Feminino
Análise de Alimentos
Seres Humanos
Masculino
Emirados Árabes Unidos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517001027


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[PMID]:28404579
[Au] Autor:Evans CE; Greenwood DC; Threapleton DE; Gale CP; Cleghorn CL; Burley VJ
[Ad] Endereço:Nutritional Epidemiology Group, School of Food Science and Nutrition, and c.e.l.evans@leeds.ac.uk.
[Ti] Título:Glycemic index, glycemic load, and blood pressure: a systematic review and meta-analysis of randomized controlled trials.
[So] Source:Am J Clin Nutr;105(5):1176-1190, 2017 May.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:High blood pressure is a strong risk factor for cardiovascular disease. The aim of this study was to determine the associations of dietary glycemic index (GI) and glycemic load (GL) with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in healthy individuals. A systematic review and meta-analysis of randomized controlled trials (RCTs) was carried out. Databases were searched for eligible RCTs in 2 phases. MEDLINE, Embase, CAB Abstracts, BIOSIS, ISI Web of Science, and the Cochrane Library were searched from January 1990 to December 2009. An updated search was undertaken with the use of MEDLINE and Embase from January 2010 to September 2016. Trials were included if they reported author-defined high- and low-GI or -GL diets and blood pressure, were of ≥6 wk duration, and comprised healthy participants without chronic conditions. Data were extracted and analyzed with the use of Stata statistical software. Pooled estimates and 95% CIs were calculated with the use of weighted mean differences and random-effects models. Data were extracted from 14 trials comprising 1097 participants. Thirteen trials provided information on differences in GI between control and intervention arms. A median reduction in GI of 10 units reduced the overall pooled estimates for SBP and DBP by 1.1 mm Hg (95% CI: -0.3, 2.5 mm Hg; = 0.11) and 1.3 mm Hg (95% CI: 0.2 mm Hg, 2.3; = 0.02), respectively. Nine trials reported information on differences in GL between arms. A median reduction in GL of 28 units reduced the overall pooled estimates for SBP and DBP by 2.0 mm Hg (95% CI: 0.2, 3.8 mm Hg; = 0.03) and 1.4 mm Hg (95% CI: 0.1, 2.6 mm Hg; = 0.03), respectively. This review of healthy individuals indicated that a lower glycemic diet may lead to important reductions in blood pressure. However, many of the trials included in the analysis reported important sources of bias. This trial was registered at PROSPERO as CRD42016049026.
[Mh] Termos MeSH primário: Pressão Sanguínea
Dieta
Comportamento Alimentar
Índice Glicêmico
Carga Glicêmica
Hipertensão/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Hipertensão/fisiopatologia
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.143685


  9 / 94 MEDLINE  
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[PMID]:28338608
[Au] Autor:Jung CH; Choi KM
[Ad] Endereço:Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University School of Medicine, Bucheon Hospital, 170 Jomaru-Ro, Wonmi-Gu, Bucheon-Si, Gyeonggi-Do 420-767, Korea. chanh@schmc.ac.kr.
[Ti] Título:Impact of High-Carbohydrate Diet on Metabolic Parameters in Patients with Type 2 Diabetes.
[So] Source:Nutrients;9(4), 2017 Mar 24.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In patients with type 2 diabetes mellitus (T2DM), whether dietary carbohydrates have beneficial or detrimental effects on cardiometabolic risk factors has drawn attention. Although a high-carbohydrate (HC) diet and a low-carbohydrate (LC) diet have gained popularity for several decades, there is scarce review focusing on the effects of HC diet on glucose, lipids and body weight in patients with T2DM. In this review, we examined recently-published literature on the effects of HC diets on metabolic parameters in T2DM. HC diets are at least as effective as LC diets, leading to significant weight loss and a reduction in plasma glucose, HbA1c and low density lipoprotein-cholesterol (LDL-C) levels. The major concern is that HC diets may raise serum triglyceride levels and reduce high density lipoprotein-cholesterol (HDL-C) levels, increasing the risk of cardiovascular disease. However, these untoward effects were not a persistent consequence and may be ameliorated with the consumption of a low glycemic index (GI)/low glycemic load (GL) and high fiber. Carbohydrate intake should be individualized, and low caloric intake remains a crucial factor to improve insulin sensitivity and reduce body weight; however, an HC diet, rich in fiber and with a low GI/GL, may be recommendable in patients with T2DM.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/dietoterapia
Dieta da Carga de Carboidratos
Carboidratos da Dieta/administração & dosagem
[Mh] Termos MeSH secundário: Glicemia/metabolismo
Peso Corporal
HDL-Colesterol/sangue
LDL-Colesterol/sangue
Dieta com Restrição de Carboidratos
Fibras na Dieta/administração & dosagem
Hemoglobina A Glicada/metabolismo
Índice Glicêmico
Carga Glicêmica
Seres Humanos
Resistência à Insulina
Ensaios Clínicos Controlados Aleatórios como Assunto
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Cholesterol, HDL); 0 (Cholesterol, LDL); 0 (Dietary Carbohydrates); 0 (Dietary Fiber); 0 (Glycated Hemoglobin A); 0 (Triglycerides)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE


  10 / 94 MEDLINE  
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[PMID]:28228332
[Au] Autor:Levenson AE; Milliren CE; Biddinger SB; Ebbeling CB; Feldman HA; Ludwig DS; de Ferranti SD
[Ad] Endereço:Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: Amy.Levenson@unc.edu.
[Ti] Título:Calorically restricted diets decrease PCSK9 in overweight adolescents.
[So] Source:Nutr Metab Cardiovasc Dis;27(4):342-349, 2017 Apr.
[Is] ISSN:1590-3729
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Nutritional therapy is the first line approach to treatment of hyperlipidemia in childhood. Proprotein convertase subtilisin kexin type 9 (PCSK9) is a key regulator of plasma cholesterol levels and a target of novel lipid-lowering pharmacotherapies. We examined the effects of an intensive nutritional intervention on PCSK9 levels in overweight adolescents with cardiovascular disease (CVD) risk factors. METHODS AND RESULTS: Twenty seven obese and overweight adolescents with CVD risk factors were assigned to either a low fat or low glycemic load diet. During an 8-week "Intensive Phase," assigned meals were delivered to the home, and all participants received weekly in-person home nutrition counseling and phone calls. The subjects then underwent a 4-month "Maintenance Phase" without food provision and with no in-person contact. Anthropometric measurements, laboratory data, and serum PCSK9 protein levels were measured at baseline, 8 weeks, and 6 months. PCSK9 decreased by 16.5% at 8 weeks (201.2 ± 56.3 vs 165.6 ± 58.4 ng/mL; p < 0.001); PCSK9 levels returned to baseline levels at 6 months, after the Maintenance Phase. Change in PCSK9 was associated with change in fasting insulin, HOMA-IR, and AUC insulin, independent of weight loss. CONCLUSIONS: PCSK9 decreased in youth participating in an intensive dietary intervention. Change in HOMA-IR was associated with change in PCSK9, independent of weight loss, suggesting an important relationship with insulin sensitivity. ClinicalTrials.gov Identifier: NCT01080339.
[Mh] Termos MeSH primário: Dieta com Restrição de Gorduras
Ingestão de Energia
Carga Glicêmica
Obesidade Pediátrica/dietoterapia
Pró-Proteína Convertase 9/sangue
[Mh] Termos MeSH secundário: Adolescente
Fatores Etários
Biomarcadores/sangue
Glicemia/metabolismo
Boston
Criança
Aconselhamento
Regulação para Baixo
Feminino
Seres Humanos
Insulina/sangue
Resistência à Insulina
Masculino
Obesidade Pediátrica/diagnóstico
Obesidade Pediátrica/enzimologia
Obesidade Pediátrica/fisiopatologia
Fatores de Tempo
Resultado do Tratamento
Perda de Peso
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biomarkers); 0 (Blood Glucose); 0 (Insulin); EC 3.4.21.- (PCSK9 protein, human); EC 3.4.21.- (Proprotein Convertase 9)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE



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