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[PMID]:29444390
[Au] Autor:Goode J; Veyckemans F; Tourtchaninoff M; Grosu I
[Ti] Título:The use of alpha 2 agonists during idiopathic scoliosis repair : a narrative review of the literature.
[So] Source:Acta Anaesthesiol Belg;67(2):53-62, 2016.
[Is] ISSN:0001-5164
[Cp] País de publicação:Belgium
[La] Idioma:eng
[Ab] Resumo:Alpha 2 agonists are appreciated drugs designed for the peri-operative period, because of their anxiolytic, sedative and analgesic properties. However, they are usually avoided during scoliosis surgery, a longlasting major procedure involving healthy patients, because of their potential effects on Somatosensory and Motorevoked potentials. The absence ofrecommendations suggests that their effects on evoked potentials are still unclear. Thus, we tried in this narrative review to identify the literature representative of the effects of clonidine and dexmedetomidine on evoked potentials, on human beings, published between 1988 and 2015 in English or French, using GOOGLE SCHOLAR and PUBMED. Paucity of literature prevented any conclusion about Clonidine's effects on evoked potentials, but no data suggested a noxious effect of Clonidine on evoked potentials, used in oral premedication (300 µg) or during the procedure (2 to 5 µg/kg). If literature was more extensive for dexmedetomidine, studies were still controversial. Although the majority of the studies did not find statistically significant differences concerning the effects of this drug on evoked potentials (loading dose of 0.3 to 1 µg/ kg followed by continuous infusion of 0.3 to 0.8 µg/kg/h), 2 case reports and 2 studies described substantial decreases. However, dexmedetomidine's shorter duration of action allowed a quick return to basal situation within an hour. In conclusion, more studies are needed in order to evaluate the effects of alpha 2 agonists on evoked potentials and to assess the safety of their use in this setting.
[Mh] Termos MeSH primário: Agonistas de Receptores Adrenérgicos alfa 2/farmacologia
Clonidina/farmacologia
Dexmedetomidina/farmacologia
Potencial Evocado Motor/efeitos dos fármacos
Potenciais Somatossensoriais Evocados/efeitos dos fármacos
Escoliose/cirurgia
[Mh] Termos MeSH secundário: Agonistas de Receptores Adrenérgicos alfa 2/efeitos adversos
Seres Humanos
Monitorização Fisiológica
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adrenergic alpha-2 Receptor Agonists); 67VB76HONO (Dexmedetomidine); MN3L5RMN02 (Clonidine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE


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[PMID]:28463818
[Au] Autor:Rocchi L; Erro R; Antelmi E; Berardelli A; Tinazzi M; Liguori R; Bhatia K; Rothwell J
[Ad] Endereço:Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, WC1N 3BG London, United Kingdom; Department of Neurology and Psychiatry, University of Rome "Sapienza", Viale dell'Universita' 30, 00185 Rome, Italy. Electronic address: l.rocchi@ucl.ac
[Ti] Título:High frequency somatosensory stimulation increases sensori-motor inhibition and leads to perceptual improvement in healthy subjects.
[So] Source:Clin Neurophysiol;128(6):1015-1025, 2017 06.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: High frequency repetitive somatosensory stimulation (HF-RSS), which is a patterned electric stimulation applied to the skin through surface electrodes, improves two-point discrimination, somatosensory temporal discrimination threshold (STDT) and motor performance in humans. However, the mechanisms which underlie these changes are still unknown. In particular, we hypothesize that refinement of inhibition might be responsible for the improvement in spatial and temporal perception. METHODS: Fifteen healthy subjects underwent 45min of HF-RSS. Before and after the intervention several measures of inhibition in the primary somatosensory area (S1), such as paired-pulse somatosensory evoked potentials (pp-SEP), high-frequency oscillations (HFO), and STDT were tested, as well as tactile spatial acuity and short intracortical inhibition (SICI). RESULTS: HF-RSS increased inhibition in S1 tested by pp-SEP and HFO; these changes were correlated with improvement in STDT. HF-RSS also enhanced bumps detection, while there was no change in grating orientation test. Finally there was an increase in SICI, suggesting widespread changes in cortical sensorimotor interactions. CONCLUSIONS: These findings suggest that HF-RSS can improve spatial and temporal tactile abilities by increasing the effectiveness of inhibitory interactions in the somatosensory system. Moreover, HF-RSS induces changes in cortical sensorimotor interaction. SIGNIFICANCE: HF-RSS is a repetitive electric stimulation technique able to modify the effectiveness of inhibitory circuitry in the somatosensory system and primary motor cortex.
[Mh] Termos MeSH primário: Potenciais Somatossensoriais Evocados
Inibição Neural
Córtex Sensório-Motor/fisiologia
Percepção do Tato
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
Meia-Idade
Limiar Sensorial
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:27777001
[Au] Autor:Pirttimäki T; Salo RA; Shatillo A; Kettunen MI; Paasonen J; Sierra A; Jokivarsi K; Leinonen V; Andrade P; Quittek S; Pitkänen A; Gröhn O
[Ad] Endereço:Department of Neurobiology, A.I. Virtanen Institute for Molecular Medicine, University of Eastern Finland, 70211, Kuopio, Finland. Electronic address: tiina.pirttimaki@uef.fi.
[Ti] Título:Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents.
[So] Source:J Neurosci Methods;274:154-163, 2016 Dec 01.
[Is] ISSN:1872-678X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Simultaneous EEG-fMRI is a valuable tool in the clinic as it provides excellent temporal and spatial information about normal and diseased brain function. In pre-clinical research with small rodents, obtaining simultaneous EEG-fMRI in longitudinal studies faces a number of challenges, including issues related to magnetic susceptibility artifacts. NEW METHOD: Here, we demonstrate a method for permanent MRI RF-coil and EEG electrode implantation in rats that is suitable for long-term chronic follow-up studies in both stimulus and resting-state fMRI paradigms. RESULTS: Our findings showed that the screw-free implantation method is well suited for long-term follow-up studies in both freely moving video-EEG settings and fMRI without causing MRI susceptibility artifacts. Furthermore, the results demonstrated that a multimodal approach can be used to track the progression of structural and functional changes. COMPARISON WITH EXISTING METHODS: The quality of both MRI and EEG data were comparable to those obtained with traditional methods with the benefit of combining them into artifact-free simultaneous recordings. The signal-to-noise ratios of the MRI images obtained with the implanted RF-coil were similar to those using a quadrature coil and were therefore suitable for resting-state fMRI experiments. Similarly, EEG data collected with the RF-coil/electrode set-up were comparable to EEG recorded with traditional epidural screw electrodes. CONCLUSION: This new multimodal EEG-fMRI approach provides a novel tool for concomitant analysis and follow-up of anatomic and functional MRI, as well as electrographic changes in a preclinical research.
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Encéfalo/fisiopatologia
Eletrodos Implantados
Eletroencefalografia
Imagem por Ressonância Magnética/métodos
[Mh] Termos MeSH secundário: Animais
Encéfalo/efeitos dos fármacos
Lesões Encefálicas/induzido quimicamente
Lesões Encefálicas/diagnóstico por imagem
Lesões Encefálicas/fisiopatologia
Mapeamento Encefálico
Potenciais Somatossensoriais Evocados/efeitos dos fármacos
Potenciais Somatossensoriais Evocados/fisiologia
Agonistas de Aminoácidos Excitatórios/toxicidade
Seguimentos
Processamento de Imagem Assistida por Computador
Ácido Caínico/toxicidade
Masculino
Monitorização Fisiológica
Oxigênio/sangue
Ratos
Ratos Wistar
Razão Sinal-Ruído
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Excitatory Amino Acid Agonists); S88TT14065 (Oxygen); SIV03811UC (Kainic Acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE


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[PMID]:28953623
[Au] Autor:Zhou Q; Li M; Yi L; He B; Li X; Jiang Y
[Ad] Endereço:aDepartment of Neurosurgery bDepartment of Neurosurgery Neurophysiology Center, Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
[Ti] Título:Intraoperative neuromonitoring during brain arteriovenous malformation microsurgeries and postoperative dysfunction: A retrospective follow-up study.
[So] Source:Medicine (Baltimore);96(39):e8054, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To evaluate the effectiveness of intraoperative neuromonitoring (IONM) during arteriovenous malformation (AVM) surgery, we retrospectively analyzed neurologic dysfunction in patients who underwent AVM surgery with (IONM group) and without IONM (non-IONM group). The sensitivity and specificity of short-term neurologic dysfunction were calculated in the IONM group. IONM parameters were obtained in all patients. There was no significant difference in neurologic dysfunction between patients in the IONM and non-IONM groups. The short-term hemiplegia ratio among grade III patients in the IONM group was significantly lower than the non-IONM group. The sensitivity of IONM for predicting short-term neurologic dysfunction in the IONM group was 86.7% with a specificity of 100%. Of the different parameters monitored intraoperatively, the somatosensory-evoked potential (SEP), maximum expiratory pressure (MEP), and brain auditory-evoked potential (BAEP) may be beneficial in grade III and IV patients. The BAEP complemented the SEP and MEP. Electromyography and the visual-evoked potential have promise in preserving cranial nerve and visual function. For grades I and II patients, no SEP monitoring was safe. For grade V patients, further investigation is required to prevent neurologic dysfunction because of highly related risks for disability and postoperative complications. Moreover, a larger sample size is required to demonstrate the usefulness of IONM during awake craniotomies.
[Mh] Termos MeSH primário: Malformações Arteriovenosas Intracranianas/cirurgia
Monitorização Neurofisiológica Intraoperatória/métodos
Microcirurgia/efeitos adversos
Complicações Pós-Operatórias/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Potenciais Evocados Auditivos do Tronco Encefálico
Potenciais Somatossensoriais Evocados
Feminino
Seguimentos
Hemiplegia/diagnóstico
Seres Humanos
Masculino
Pressões Respiratórias Máximas
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008054


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[PMID]:28931642
[Au] Autor:Canafoglia L; Ferlazzo E; Michelucci R; Striano P; Magaudda A; Gambardella A; Pasini E; Belcastro V; Riguzzi P; Fanella M; Granata T; Beccaria F; Trentini C; Bianchi A; Aguglia U; Panzica F; Franceschetti S
[Ad] Endereço:From the Department of Neurophysiopathology and Epilepsy Centre (L.C., C.T., F.P., S.F.) and Pediatric Neurology (T.G.), IRCCS Foundation C. Besta Neurological Institute, Milan; Department of Medical and Surgical Sciences (E.F., A.G., U.A.), Magna Graecia University, Catanzaro; Regional Epilepsy Cen
[Ti] Título:Variable course of Unverricht-Lundborg disease: Early prognostic factors.
[So] Source:Neurology;89(16):1691-1697, 2017 Oct 17.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To explore the course of Unverricht-Lundborg disease (EPM1) and identify the risk factors for severity, we investigated the time course of symptoms and prognostic factors already detectable near to disease onset. METHODS: We retrospectively evaluated the features of 59 Italian patients carrying the expansion mutation, and coded the information every 5 years after the disease onset in order to describe the cumulative time-dependent probability of reaching disabling myoclonus, relevant cognitive impairment, and inability to work, and evaluated the influence of early factors using the log-rank test. The risk factors were included in a Cox multivariate proportional hazards regression model. RESULTS: Disabling myoclonus occurred an average of 32 years after disease onset, whereas cognitive impairment occurred a little later. An age at onset of less than 12 years, the severity of myoclonus at the time of first assessment, and seizure persistence more than 10 years after onset affected the timing of disabling myoclonus and cognitive decline. Most patients became unable to work years before the appearance of disabling myoclonus or cognitive decline. CONCLUSIONS: A younger age at onset, early severe myoclonus, and seizure persistence are predictors of a more severe outcome. All of these factors may be genetically determined, but the greater hyperexcitability underlying more severe seizures and myoclonus at onset may also play a role by increasing cell damage due to reduced cystatin B activity.
[Mh] Termos MeSH primário: Síndrome de Unverricht-Lundborg/diagnóstico
Síndrome de Unverricht-Lundborg/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idade de Início
Análise de Variância
Anticonvulsivantes/uso terapêutico
Catepsina B/genética
Eletroencefalografia
Potenciais Somatossensoriais Evocados/efeitos dos fármacos
Feminino
Seres Humanos
Itália
Masculino
Meia-Idade
Fenitoína/uso terapêutico
Prognóstico
Estudos Retrospectivos
Síndrome de Unverricht-Lundborg/tratamento farmacológico
Síndrome de Unverricht-Lundborg/genética
Ácido Valproico/uso terapêutico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticonvulsants); 614OI1Z5WI (Valproic Acid); 6158TKW0C5 (Phenytoin); EC 3.4.22.1 (CTSB protein, human); EC 3.4.22.1 (Cathepsin B)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000004518


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[PMID]:28826015
[Au] Autor:Fedele T; Schönenberger C; Curio G; Serra C; Krayenbühl N; Sarnthein J
[Ad] Endereço:Neurosurgery Department, University Hospital Zurich, Zurich, Switzerland. Electronic address: tommaso.fedele@usz.ch.
[Ti] Título:Intraoperative subdural low-noise EEG recording of the high frequency oscillation in the somatosensory evoked potential.
[So] Source:Clin Neurophysiol;128(10):1851-1857, 2017 Oct.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The detectability of high frequency oscillations (HFO, >200Hz) in the intraoperative ECoG is restricted by their low signal-to-noise ratio (SNR). Using the somatosensory evoked HFO, we quantify how HFO detectability can benefit from a custom-made low-noise amplifier (LNA). METHODS: In 9 patients undergoing tumor surgery in the central region, subdural strip electrodes were placed for intraoperative neurophysiological monitoring. We recorded the somatosensory evoked potential (SEP) simultaneously by custom-made LNA and by a commercial device (CD). We varied the stimulation rate between 1.3 and 12.7Hz to tune the SNR of the N20 component and the evoked HFO and quantified HFO detectability at the single trial level. In three patients we compared Propofol® and Sevoflurane® anesthesia. RESULTS: In the average, amplitude decreased in both in N20 and evoked HFO amplitude with increasing stimulation rate (p<0.05). We detected a higher percentage of single trial evoked HFO with the LNA (p<0.001) for recordings with low impedance (<5kΩ). Average amplitudes were indistinguishable between anesthesia compounds. CONCLUSION: Low-noise amplification improves the detection of the evoked HFO in recordings with subdural electrodes with low impedance. SIGNIFICANCE: Low-noise EEG might critically improve the detectability of interictal spontaneous HFO in subdural and possibly in scalp recordings.
[Mh] Termos MeSH primário: Eletrocorticografia/métodos
Potenciais Somatossensoriais Evocados/fisiologia
Monitorização Neurofisiológica Intraoperatória/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Eletroencefalografia/métodos
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170822
[St] Status:MEDLINE


  7 / 11680 MEDLINE  
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[PMID]:28701500
[Au] Autor:Liu H; MacMillian EL; Jutzeler CR; Ljungberg E; MacKay AL; Kolind SH; Mädler B; Li DKB; Dvorak MF; Curt A; Laule C; Kramer JLK
[Ad] Endereço:From Physics and Astronomy (H.L., A.L.M., B.M.), ICORD (H.L., C.R.J., M.F.D., C.L., J.L.K.K.), Medicine (Neurology) (E.L.M., E.L., S.H.K., D.K.B.L.), Radiology (A.L.M., D.K.B.L., C.L.), Orthopaedics (M.F.D.), Pathology & Laboratory Medicine (C.L.), and School of Kinesiology (J.L.K.K.), Universit
[Ti] Título:Assessing structure and function of myelin in cervical spondylotic myelopathy: Evidence of demyelination.
[So] Source:Neurology;89(6):602-610, 2017 Aug 08.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To assess the extent of demyelination in cervical spondylotic myelopathy (CSM) using myelin water imaging (MWI) and electrophysiologic techniques. METHODS: Somatosensory evoked potentials (SSEPs) and MWI were acquired in 14 patients with CSM and 18 age-matched healthy controls. MWI was performed on a 3.0T whole body magnetic resonance scanner. Myelin water fraction (MWF) was extracted for the dorsal columns and whole cord. SSEPs and MWF were also compared with conventional MRI outcomes, including T2 signal intensity, compression ratio, maximum spinal cord compression (MSCC), and maximum canal compromise (MCC). RESULTS: Group analysis showed marked differences in T2 signal intensity, compression ratio, MSCC, and MCC between healthy controls and patients with CSM. There were no group differences in MWF and SSEP latencies. However, patients with CSM with pathologic SSEPs exhibited reduction in MWF ( < 0.05). MWF was also correlated with SSEP latencies. CONCLUSION: Our findings provide evidence of decreased myelin content in the spinal cord associated with impaired spinal cord conduction in patients with CSM. While conventional MRI are of great value to define the extent of cord compression, they show a limited correlation with functional deficits (i.e., delayed SSEPs). MWI provides independent and complementary readouts to spinal cord compression, with a high specificity to detect impaired conduction.
[Mh] Termos MeSH primário: Bainha de Mielina/fisiologia
Doenças da Medula Espinal/diagnóstico por imagem
Doenças da Medula Espinal/fisiopatologia
Espondilose/diagnóstico por imagem
Espondilose/fisiopatologia
[Mh] Termos MeSH secundário: Vértebras Cervicais
Doenças Desmielinizantes/diagnóstico por imagem
Doenças Desmielinizantes/fisiopatologia
Potenciais Somatossensoriais Evocados
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Processamento de Sinais Assistido por Computador
Medula Espinal/diagnóstico por imagem
Medula Espinal/fisiopatologia
Inquéritos e Questionários
Substância Branca/diagnóstico por imagem
Substância Branca/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000004197


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[PMID]:28630252
[Au] Autor:Forschack N; Nierhaus T; Müller MM; Villringer A
[Ad] Endereço:Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany, forschack@cbs.mpg.de villringer@cbs.mpg.de.
[Ti] Título:Alpha-Band Brain Oscillations Shape the Processing of Perceptible as well as Imperceptible Somatosensory Stimuli during Selective Attention.
[So] Source:J Neurosci;37(29):6983-6994, 2017 Jul 19.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Attention filters and weights sensory information according to behavioral demands. Stimulus-related neural responses are increased for the attended stimulus. Does alpha-band activity mediate this effect and is it restricted to conscious sensory events (suprathreshold), or does it also extend to unconscious stimuli (subthreshold)? To address these questions, we recorded EEG in healthy male and female volunteers undergoing subthreshold and suprathreshold somatosensory electrical stimulation to the left or right index finger. The task was to detect stimulation at the randomly alternated cued index finger. Under attention, amplitudes of somatosensory evoked potentials increased 50-60 ms after stimulation (P1) for both suprathreshold and subthreshold events. Prestimulus amplitude of peri-Rolandic alpha, that is mu, showed an inverse relationship to P1 amplitude during attention compared to when the finger was unattended. Interestingly, intermediate and high amplitudes of mu rhythm were associated with the highest P1 amplitudes during attention and smallest P1 during lack of attention, that is, these levels of alpha rhythm seemed to optimally support the behavioral goal ("detect" stimuli at the cued finger while ignoring the other finger). Our results show that attention enhances neural processing for both suprathreshold and subthreshold stimuli and they highlight a rather complex interaction between attention, Rolandic alpha activity, and their effects on stimulus processing. Attention is crucial in prioritizing processing of relevant perceptible (suprathreshold) stimuli: it filters and weights sensory input. The present study investigates the controversially discussed question whether this attention effect extends to imperceptible (subthreshold) stimuli as well. We found noninvasive EEG signatures for attentional modulation of neural events following perceptible and imperceptible somatosensory stimulation in human participants. Specifically, stimulus processing for both kinds of stimulation, subthreshold and suprathreshold, is enhanced by attention. Interestingly, Rolandic alpha rhythm strength and its influence on stimulus processing are strikingly altered by attention most likely to optimally achieve the behavioral goal.
[Mh] Termos MeSH primário: Ritmo alfa/fisiologia
Viés de Atenção/fisiologia
Estimulação Elétrica/métodos
Potenciais Somatossensoriais Evocados/fisiologia
Limiar Sensorial/fisiologia
Córtex Somatossensorial/fisiologia
[Mh] Termos MeSH secundário: Adulto
Eletroencefalografia/métodos
Feminino
Seres Humanos
Masculino
Desempenho Psicomotor/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.2582-16.2017


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[PMID]:28618295
[Au] Autor:van den Broeke EN; de Vries B; Lambert J; Torta DM; Mouraux A
[Ad] Endereço:Institute of Neuroscience, Université catholique de Louvain, B-1200 Brussels, Belgium. Electronic address: Emanuel.vandenbroeke@uclouvain.be.
[Ti] Título:Phase-locked and non-phase-locked EEG responses to pinprick stimulation before and after experimentally-induced secondary hyperalgesia.
[So] Source:Clin Neurophysiol;128(8):1445-1456, 2017 Aug.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Pinprick-evoked brain potentials (PEPs) have been proposed as a technique to investigate secondary hyperalgesia and central sensitization in humans. However, the signal-to-noise (SNR) of PEPs is low. Here, using time-frequency analysis, we characterize the phase-locked and non-phase-locked EEG responses to pinprick stimulation, before and after secondary hyperalgesia. METHODS: Secondary hyperalgesia was induced using high-frequency electrical stimulation (HFS) of the left/right forearm skin in 16 volunteers. EEG responses to 64 and 96mN pinprick stimuli were elicited from both arms, before and 20min after HFS. RESULTS: Pinprick stimulation applied to normal skin elicited a phase-locked low-frequency (<5Hz) response followed by a reduction of alpha-band oscillations (7-10Hz). The low-frequency response was significantly increased when pinprick stimuli were delivered to the area of secondary hyperalgesia. There was no change in the reduction of alpha-band oscillations. Whereas the low-frequency response was enhanced for both 64 and 96mN intensities, PEPs analyzed in the time domain were only significantly enhanced for the 64mN intensity. CONCLUSIONS: Time-frequency analysis may be more sensitive than conventional time-domain analysis in revealing EEG changes associated to secondary hyperalgesia. SIGNIFICANCE: Time-frequency analysis of PEPs can be used to investigate central sensitization in humans.
[Mh] Termos MeSH primário: Eletroencefalografia/métodos
Potenciais Somatossensoriais Evocados/fisiologia
Hiperalgesia/fisiopatologia
Medição da Dor/métodos
[Mh] Termos MeSH secundário: Adulto
Estimulação Elétrica/efeitos adversos
Estimulação Elétrica/métodos
Feminino
Seres Humanos
Hiperalgesia/diagnóstico
Hiperalgesia/etiologia
Masculino
Estimulação Física/efeitos adversos
Estimulação Física/métodos
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE


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[PMID]:28617862
[Au] Autor:Hihara H; Kanetaka H; Kanno A; Koeda S; Nakasato N; Kawashima R; Sasaki K
[Ad] Endereço:Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Miyagi, Japan.
[Ti] Título:Evaluating age-related change in lip somatosensation using somatosensory evoked magnetic fields.
[So] Source:PLoS One;12(6):e0179323, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Somatosensory evoked fields (SEFs) to electrical stimulation on the right and left sides of the lower lip were measured using magnetoencephalography and compared in the bilateral hemispheres of 31 healthy normal young and 29 healthy normal elderly subjects to evaluate age-related change in lip somatosensation. The initial peak of the response around 13 ms, designated as N13m, and the second peak of the response, designated as P21m, were investigated. The N13m response, which was detected in 22 of 62 hemispheres in young adults and 37 of 58 hemispheres in elderly adults, showed significantly prolonged latency and increased equivalent current dipole (ECD) moment in the elderly adults. The P21m response, which was detected in 56 of 62 hemispheres in young adults and in 52 of 58 hemispheres in elderly adults, showed longer peak latency in the elderly adults. No significant difference was found in the ECD moment for P21m, which suggests that aging affected the SEFs of the lip somatosensation, but the effects of aging on N13m and P21m differed. Prolonged latency and increased ECD moment of N13m might result from decreased peripheral conduction and increased cortical excitation system associated with aging. Therefore, the initial response component might be an objective parameter for investigating change in lip function with age.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Córtex Cerebral/fisiologia
Potenciais Somatossensoriais Evocados/fisiologia
Lábio/fisiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Estimulação Elétrica
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179323



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