Base de dados : MEDLINE
Pesquisa : G07.265.753 [Categoria DeCS]
Referências encontradas : 26329 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 2633 ir para página                         

  1 / 26329 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29480857
[Au] Autor:Shi M; Qi H; Ding H; Chen F; Xin Z; Zhao Q; Guan S; Shi H
[Ad] Endereço:Department of Ultrasound, Qianfoshan Hospital Affiliated to Shandong University, Jinan.
[Ti] Título:Electrophysiological examination and high frequency ultrasonography for diagnosis of radial nerve torsion and compression.
[So] Source:Medicine (Baltimore);97(2):e9587, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aims to evaluate the value of electrophysiological examination and high frequency ultrasonography in the differential diagnosis of radial nerve torsion and radial nerve compression.Patients with radial nerve torsion (n = 14) and radial nerve compression (n = 14) were enrolled. The results of neurophysiological and high frequency ultrasonography were compared.Electrophysiological examination and high-frequency ultrasonography had a high diagnostic rate for both diseases with consistent results. Of the 28 patients, 23 were positive for electrophysiological examination, showing decreased amplitude and decreased conduction velocity of radial nerve; however, electrophysiological examination cannot distinguish torsion from compression. A total of 27 cases showed positive in ultrasound examinations among all 28 cases. On ultrasound images, the nerve was thinned at torsion site whereas thickened at the distal ends of torsion. The diameter and cross-sectional area of torsion or compression determined the nerve damage, and ultrasound could locate the nerve injury site and measure the length of the nerve.Electrophysiological examination and high-frequency ultrasonography can diagnose radial neuropathy, with electrophysiological examination reflecting the neurological function, and high-frequency ultrasound differentiating nerve torsion from compression.
[Mh] Termos MeSH primário: Eletrodiagnóstico
Síndromes de Compressão Nervosa/diagnóstico
Nervo Radial/diagnóstico por imagem
Nervo Radial/fisiopatologia
Neuropatia Radial/diagnóstico
Ultrassonografia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Diagnóstico Diferencial
Feminino
Seres Humanos
Masculino
Síndromes de Compressão Nervosa/fisiopatologia
Síndromes de Compressão Nervosa/cirurgia
Condução Nervosa
Nervo Radial/cirurgia
Neuropatia Radial/fisiopatologia
Neuropatia Radial/cirurgia
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009587


  2 / 26329 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28743796
[Au] Autor:Roberts SL; Dun XP; Doddrell RDS; Mindos T; Drake LK; Onaitis MW; Florio F; Quattrini A; Lloyd AC; D'Antonio M; Parkinson DB
[Ad] Endereço:Plymouth University Peninsula Schools of Medicine and Dentistry, John Bull Building, Plymouth Science Park, Plymouth PL6 8BU, UK.
[Ti] Título:Sox2 expression in Schwann cells inhibits myelination and induces influx of macrophages to the nerve.
[So] Source:Development;144(17):3114-3125, 2017 09 01.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Correct myelination is crucial for the function of the peripheral nervous system. Both positive and negative regulators within the axon and Schwann cell function to ensure the correct onset and progression of myelination during both development and following peripheral nerve injury and repair. The Sox2 transcription factor is well known for its roles in the development and maintenance of progenitor and stem cell populations, but has also been proposed as a negative regulator of myelination in Schwann cells. We wished to test fully whether Sox2 regulates myelination and show here that, in mice, sustained Sox2 expression blocks myelination in the peripheral nerves and maintains Schwann cells in a proliferative non-differentiated state, which is also associated with increased inflammation within the nerve. The plasticity of Schwann cells allows them to re-myelinate regenerated axons following injury and we show that re-myelination is also blocked by Sox2 expression in Schwann cells. These findings identify Sox2 as a physiological regulator of Schwann cell myelination and its potential to play a role in disorders of myelination in the peripheral nervous system.
[Mh] Termos MeSH primário: Macrófagos/metabolismo
Bainha de Mielina/metabolismo
Nervos Periféricos/metabolismo
Fatores de Transcrição SOXB1/metabolismo
Células de Schwann/metabolismo
[Mh] Termos MeSH secundário: Animais
Biomarcadores/metabolismo
Caderinas/metabolismo
Proliferação Celular
Proteína 2 de Resposta de Crescimento Precoce/metabolismo
Proteínas de Fluorescência Verde/metabolismo
Camundongos Transgênicos
Atividade Motora
Condução Nervosa
Traumatismos dos Nervos Periféricos/metabolismo
Traumatismos dos Nervos Periféricos/patologia
Nervos Periféricos/patologia
Nervos Periféricos/ultraestrutura
Proteínas Proto-Oncogênicas c-jun/metabolismo
Ratos
Recuperação de Função Fisiológica
Células de Schwann/patologia
Transgenes
beta Catenina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cadherins); 0 (Early Growth Response Protein 2); 0 (Proto-Oncogene Proteins c-jun); 0 (SOXB1 Transcription Factors); 0 (beta Catenin); 147336-22-9 (Green Fluorescent Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1242/dev.150656


  3 / 26329 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29257018
[Au] Autor:Zhu D; Tapadia MD; Palispis W; Luu M; Wang W; Gupta R
[Ad] Endereço:Peripheral Nerve Research Laboratory, Department of Orthopaedic Surgery, University of California, Irvine, Irvine, California.
[Ti] Título:Attenuation of Robust Glial Scar Formation Facilitates Functional Recovery in Animal Models of Chronic Nerve Compression Injury.
[So] Source:J Bone Joint Surg Am;99(24):e132, 2017 Dec 20.
[Is] ISSN:1535-1386
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Late surgery for chronic nerve compression injuries usually improves sensation but rarely reverses motor atrophy. We hypothesized that a persistent glial scar after chronic nerve compression injury might account for poor motor recovery and that degradation of the glial scar as an adjunct to surgical decompression would improve functional recovery. METHODS: A previously described model of chronic nerve compression injury was created in C57BL/6 mice and Sprague-Dawley rats, and the nerves were harvested early or late after electrophysiological confirmation of the injury. Western blot, polymerase chain reaction, and quantitative immunohistochemical analyses were performed to determine levels of chondroitin sulfate proteoglycans and extracellular matrix molecules. Subsets of mice were treated either with surgical decompression alone or with decompression coupled with intraepineurial injection of a low dose (0.1 µgµL) or a high dose (0.2 µg/µL) of chondroitinase ABC at 6 weeks after injury. RESULTS: Aggrecan showed the greatest change in mRNA and protein levels at the early and late time points following creation of the chronic nerve compression injury. Quantitative immunohistochemical analysis revealed early aggrecan upregulation localized primarily to the endoneurium and late upregulation localized to the perineurium and epineurium (p < 0.0105). Quantitative immunohistochemical analysis for collagen IV, laminin-α2, and fibronectin also showed early upregulation with perineurial scarring. Quantitative immunohistochemical analysis and Western blot analysis for aggrecan demonstrated a marked increase in the endoneurium at the early time points and upregulation of expression in the epineurium and perineurium at the late time points. Decompression along with intraepineurial injection of high-dose chondroitinase ABC at 6 weeks after creation of the compression injury resulted in marked attenuation of decorin and aggrecan expression with functional improvement in nerve conduction velocity. CONCLUSIONS: Significant upregulation of chondroitin sulfate proteoglycans and other extracellular matrix components contributes to the pathogenesis of compression neuropathies in murine models. The administration of chondroitinase ABC degrades these chondroitin sulfate proteoglycans and improves functional recovery after chronic nerve compression injury; thus, it can be considered as a possible therapeutic adjunct.
[Mh] Termos MeSH primário: Condroitina ABC Liase/farmacologia
Cicatriz/prevenção & controle
Descompressão Cirúrgica/métodos
Síndromes de Compressão Nervosa/tratamento farmacológico
Traumatismos dos Nervos Periféricos/tratamento farmacológico
Traumatismos dos Nervos Periféricos/patologia
[Mh] Termos MeSH secundário: Agrecanas/farmacologia
Análise de Variância
Animais
Western Blotting
Doença Crônica
Modelos Animais de Doenças
Injeções Intralesionais
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Síndromes de Compressão Nervosa/patologia
Síndromes de Compressão Nervosa/cirurgia
Condução Nervosa/efeitos dos fármacos
Traumatismos dos Nervos Periféricos/cirurgia
RNA Mensageiro/efeitos dos fármacos
Distribuição Aleatória
Ratos
Ratos Sprague-Dawley
Reação em Cadeia da Polimerase em Tempo Real/métodos
Recuperação de Função Fisiológica/fisiologia
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aggrecans); 0 (RNA, Messenger); EC 4.2.2.20 (Chondroitin ABC Lyase)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.17.00396


  4 / 26329 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
[PMID]:29236890
[Au] Autor:Maranhão AA; Carvalho SRDS; Caetano MR; Alamy AH; Peixoto EM; Filgueiras PDEP
[Ad] Endereço:Universidade Federal do Estado do Rio de Janeiro, Faculdade de Medicina, Departamento de Pneumologia, Rio de Janeiro RJ, Brasil.
[Ti] Título:Phrenic nerve conduction studies: normative data and technical aspects.
[So] Source:Arq Neuropsiquiatr;75(12):869-874, 2017 Dec.
[Is] ISSN:1678-4227
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of the present study was to define normative data of phrenic nerve conduction parameters of a healthy population. METHODS: Phrenic nerve conduction studies were performed in 27 healthy volunteers. RESULTS: The normative limits for expiratory phrenic nerve compound muscle action potential were: amplitude (0.47 mv - 0.83 mv), latency (5.74 ms - 7.10 ms), area (6.20 ms/mv - 7.20 ms/mv) and duration (18.30 ms - 20.96 ms). Inspiratory normative limits were: amplitude (0.67 mv - 1.11 mv), latency (5.90 ms - 6.34 ms), area (5.62 ms/mv - 6.72 ms/mv) and duration (13.77 ms - 15.37 ms). CONCLUSION: The best point of phrenic nerve stimulus in the neck varies among individuals between the medial and lateral border of the clavicular head of the sternocleidomastoid muscle and stimulation of both sites, then choosing the best phrenic nerve response, seems to be the appropriate procedure.
[Mh] Termos MeSH primário: Potenciais de Ação/fisiologia
Condução Nervosa/fisiologia
Nervo Frênico/fisiologia
Tempo de Reação/fisiologia
[Mh] Termos MeSH secundário: Adulto
Estimulação Elétrica
Eletromiografia
Feminino
Voluntários Saudáveis
Seres Humanos
Masculino
Meia-Idade
Exame Neurológico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE


  5 / 26329 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28457000
[Au] Autor:O'gorman CM; Weikamp JG; Baria M; Van Den Engel-Hoek L; Kassardjian C; Van Alfen N; Boon AJ
[Ad] Endereço:Department of Neurology, Mayo Clinic, Rochester, Minnesota, 55905, USA.
[Ti] Título:Detecting fasciculations in cranial nerve innervated muscles with ultrasound in amyotrophic lateral sclerosis.
[So] Source:Muscle Nerve;56(6):1072-1076, 2017 Dec.
[Is] ISSN:1097-4598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Cranial muscle fasciculations may be difficult to detect in amyotrophic lateral sclerosis (ALS). Ultrasound (US) detection of fasciculations in these muscles may have clinical utility. METHODS: Patients with suspected ALS were prospectively enrolled. Nerve conduction studies, needle electromyography (EMG), and US examination of cranial muscles were performed. Controls were examined by US only. Fasciculations were counted and scored for each muscle after 10 or 30 seconds. RESULTS: There were 84 patients with ALS. Fasciculations were most frequently found in the genioglossus muscle. Overall, detection rates by US and EMG were similar, but US was more likely to detect frequent fasciculations. Fasciculations were rare in controls, seen in 7 of 1,090 (0.6%) muscles. No control had > 5 fasciculations in any muscle. DISCUSSION: Fasciculations were frequently detected in cranial muscles of patients with ALS. US was found to be a sensitive method, and was not impaired by factors such as anxiety and the inability of the patient to relax. Muscle Nerve 56: 1072-1076, 2017.
[Mh] Termos MeSH primário: Esclerose Amiotrófica Lateral/diagnóstico por imagem
Nervos Cranianos/diagnóstico por imagem
Fasciculação/diagnóstico por imagem
Músculo Esquelético/diagnóstico por imagem
Músculo Esquelético/inervação
[Mh] Termos MeSH secundário: Idoso
Esclerose Amiotrófica Lateral/fisiopatologia
Nervos Cranianos/fisiopatologia
Eletromiografia/métodos
Fasciculação/fisiopatologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Músculo Esquelético/fisiopatologia
Condução Nervosa/fisiologia
Estudos Prospectivos
Método Simples-Cego
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE
[do] DOI:10.1002/mus.25676


  6 / 26329 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29029847
[Au] Autor:Terkelsen AJ; Karlsson P; Lauria G; Freeman R; Finnerup NB; Jensen TS
[Ad] Endereço:Department of Neurology, Aarhus University Hospital, Aarhus, Denmark; Danish Pain Research Center, Aarhus University, Aarhus, Denmark.
[Ti] Título:The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes.
[So] Source:Lancet Neurol;16(11):934-944, 2017 Nov.
[Is] ISSN:1474-4465
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Small fibre neuropathies are a heterogeneous group of disorders affecting thinly myelinated Aδ-fibres and unmyelinated C-fibres. Although multiple causes of small nerve fibre degeneration have been reported, including via genetic mutations, the cause of small fibre neuropathy remains unknown in up to 50% of cases. The typical clinical presentation of small fibre neuropathy is that of a symmetrical, length-dependent polyneuropathy associated with sensory or autonomic symptoms. More rarely, the clinical presentation is characterised by non-length-dependent, focal, or multifocal symptoms. The diagnostic tests to identify small fibre neuropathy include skin biopsy, quantitative sensory, and autonomic testing. Additional tests, such as those measuring small fibre-related evoked potentials and corneal confocal microscopy, might contribute to a better understanding of these neuropathies. Biochemical markers can also help in screening patients for the presence of small fibre neuropathy and to assess disease progression.
[Mh] Termos MeSH primário: Neuropatia de Pequenas Fibras/diagnóstico
Neuropatia de Pequenas Fibras/etiologia
[Mh] Termos MeSH secundário: Biópsia/métodos
Feminino
Seres Humanos
Masculino
Microscopia Confocal
Condução Nervosa/fisiologia
Pele/patologia
Neuropatia de Pequenas Fibras/genética
Neuropatia de Pequenas Fibras/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171015
[St] Status:MEDLINE


  7 / 26329 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29020118
[Au] Autor:Marmiroli P; Riva B; Pozzi E; Ballarini E; Lim D; Chiorazzi A; Meregalli C; Distasi C; Renn CL; Semperboni S; Morosi L; Ruffinatti FA; Zucchetti M; Dorsey SG; Cavaletti G; Genazzani A; Carozzi VA
[Ad] Endereço:Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
[Ti] Título:Susceptibility of different mouse strains to oxaliplatin peripheral neurotoxicity: Phenotypic and genotypic insights.
[So] Source:PLoS One;12(10):e0186250, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Peripheral neurotoxicity is one of the most distressing side effects of oxaliplatin therapy for cancer. Indeed, most patients that received oxaliplatin experience acute and/or chronic severe sensory peripheral neuropathy. However, despite similar co-morbidities, cancer stage, demographics and treatment schedule, patients develop oxaliplatin-induced peripheral neurotoxicity with remarkably different severity. This suggests individual genetic variability, which might be used to glean the mechanistic insights into oxaliplatin neurotoxicity. We characterized the susceptibility of different mice strains to oxaliplatin neurotoxicity investigating the phenotypic features of neuropathy and gene expression profiles in dorsal root ganglia of six genetically different mice strains (Balb-c, C57BL6, DBA/2J, AJ, FVB and CD1) exposed to the same oxaliplatin schedule. Differential gene expression in dorsal root ganglia from each mice strain were assayed using a genome-wide expression analysis and selected genes were validated by RT-PCR analysis. The demonstration of consistent differences in the phenotypic response to oxaliplatin across different strains is interesting to allow the selection of the appropriate strain based on the pre-defined read-out parameters. Further investigation of the correlation between gene expression changes and oxaliplatin-induced neurotoxicity phenotype in each strain will be useful to deeper investigate the molecular mechanisms of oxaliplatin neurotoxicity.
[Mh] Termos MeSH primário: Predisposição Genética para Doença
Síndromes Neurotóxicas/genética
Síndromes Neurotóxicas/patologia
Compostos Organoplatínicos/efeitos adversos
Sistema Nervoso Periférico/patologia
[Mh] Termos MeSH secundário: Doença Aguda
Animais
Biópsia
Doença Crônica
Gânglios Espinais/efeitos dos fármacos
Gânglios Espinais/patologia
Regulação da Expressão Gênica/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos
Bainha de Mielina/metabolismo
Condução Nervosa/efeitos dos fármacos
Neuralgia/complicações
Neuralgia/genética
Neuralgia/patologia
Neurônios/metabolismo
Neurônios/patologia
Síndromes Neurotóxicas/complicações
Síndromes Neurotóxicas/fisiopatologia
Medição da Dor
Sistema Nervoso Periférico/fisiopatologia
Reação em Cadeia da Polimerase em Tempo Real
Nervo Isquiático/patologia
Nervo Isquiático/fisiopatologia
Pele/patologia
Corno Dorsal da Medula Espinal/efeitos dos fármacos
Corno Dorsal da Medula Espinal/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organoplatinum Compounds); 04ZR38536J (oxaliplatin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186250


  8 / 26329 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28969380
[Au] Autor:Vale TA; Symmonds M; Polydefkis M; Byrnes K; Rice ASC; Themistocleous AC; Bennett DLH
[Ad] Endereço:Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
[Ti] Título:Chronic non-freezing cold injury results in neuropathic pain due to a sensory neuropathy.
[So] Source:Brain;140(10):2557-2569, 2017 Oct 01.
[Is] ISSN:1460-2156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Non-freezing cold injury develops after sustained exposure to cold temperatures, resulting in tissue cooling but not freezing. This can result in persistent sensory disturbance of the hands and feet including numbness, paraesthesia and chronic pain. Both vascular and neurological aetiologies of this pain have been suggested but remain unproven. We prospectively approached patients referred for clinical assessment of chronic pain following non-freezing cold injury between 12 February 2014 and 30 November 2016. Of 47 patients approached, 42 consented to undergo detailed neurological evaluations including: questionnaires to detail pain location and characteristics, structured neurological examination, quantitative sensory testing, nerve conduction studies and skin biopsy for intraepidermal nerve fibre assessment. Of the 42 study participants, all had experienced non-freezing cold injury while serving in the UK armed services and the majority were of African descent (76.2%) and male (95.2%). Many participants reported multiple exposures to cold. The median time between initial injury and referral was 3.72 years. Pain was principally localized to the hands and the feet, neuropathic in nature and in all study participants associated with cold hypersensitivity. Clinical examination and quantitative sensory testing were consistent with a sensory neuropathy. In all cases, large fibre nerve conduction studies were normal. The intraepidermal nerve fibre density was markedly reduced with 90.5% of participants having a count at or below the 0.05 centile of published normative controls. Using the Neuropathic Pain Special Interest Group of the International Association for the Study of Pain grading for neuropathic pain, 100% had probable and 95.2% definite neuropathic pain. Chronic non-freezing cold injury is a disabling neuropathic pain disorder due to a sensory neuropathy. Why some individuals develop an acute painful sensory neuropathy on sustained cold exposure is not yet known, but individuals of African descent appear vulnerable. Screening tools, such as the DN4 questionnaire, and treatment algorithms for neuropathic pain should now be used in the management of these patients.
[Mh] Termos MeSH primário: Lesão por Frio/complicações
Neuralgia/etiologia
Limiar da Dor/fisiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Hiperalgesia/fisiopatologia
Masculino
Condução Nervosa/fisiologia
Neuralgia/psicologia
Exame Neurológico
Medição da Dor
Nervos Periféricos/fisiopatologia
Qualidade de Vida/psicologia
Pele/inervação
Pele/patologia
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1093/brain/awx215


  9 / 26329 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28855494
[Au] Autor:Fujisawa M; Sano Y; Omoto M; Ogasawara JI; Koga M; Takashima H; Kanda T
[Ad] Endereço:Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medical Science.
[Ti] Título:Charcot-Marie-Tooth disease type 2 caused by homozygous MME gene mutation superimposed by chronic inflammatory demyelinating polyneuropathy.
[So] Source:Rinsho Shinkeigaku;57(9):515-520, 2017 09 30.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:We report a 59-year-old Japanese male who developed gradually worsening weakness and numbness of distal four extremities since age 50. His parents were first cousins, and blood and cerebral spinal examinations were unremarkable. Homozygous mutation of MME gene was detected and thus he was diagnosed as autosomal-recessive Charcot-Marie-Tooth disease 2T (AR-CMT2T); however, electrophysiological examinations revealed scattered demyelinative changes including elongated terminal latency in several peripheral nerve trunks. Sural nerve biopsy showed endoneurial edema and a lot of thinly myelinated nerve fibers with uneven distribution of remnant myelinated fibers within and between fascicles. Immunoglobulin treatment was initiated considering the possibility of superimposed inflammation and demyelination, and immediate clinical as well as electrophysiological improvements were noted. Our findings indicate that AR-CMT2T caused by MME mutation predisposes to a superimposed inflammatory demyelinating neuropathy. This is the first report which documented the co-existence of CMT2 and chronic inflammatory demyelinating polyneuropathy (CIDP); however, in the peripheral nervous system, neprilysin, a product of MME gene, is more abundant in myelin sheath than in axonal component. The fragility of myelin sheath due to mutated neprilysin may trigger the detrimental immune response against peripheral myelin in this patient.
[Mh] Termos MeSH primário: Doença de Charcot-Marie-Tooth/complicações
Doença de Charcot-Marie-Tooth/genética
Estudos de Associação Genética
Mutação
Neprilisina/genética
Polirradiculoneuropatia Desmielinizante Inflamatória Crônica/complicações
[Mh] Termos MeSH secundário: Doença de Charcot-Marie-Tooth/diagnóstico
Doença de Charcot-Marie-Tooth/terapia
Homozigoto
Seres Humanos
Imunoglobulinas Intravenosas/administração & dosagem
Masculino
Meia-Idade
Bainha de Mielina/enzimologia
Bainha de Mielina/imunologia
Neprilisina/metabolismo
Condução Nervosa
Nervos Periféricos/patologia
Nervos Periféricos/fisiopatologia
Polirradiculoneuropatia Desmielinizante Inflamatória Crônica/diagnóstico
Polirradiculoneuropatia Desmielinizante Inflamatória Crônica/terapia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulins, Intravenous); EC 3.4.24.11 (Neprilysin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-001036


  10 / 26329 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28855493
[Au] Autor:Yamakawa T; Mizuta K; Kurokawa K; Nagasawa H; Yamada T; Suzuki E; Wada M
[Ad] Endereço:Department of Neurology, Yamagata Prefectural Central Hospital.
[Ti] Título:Clinical characteristics of 17 adult patients with epidemic myalgia associated with human parechovirus type 3 infection.
[So] Source:Rinsho Shinkeigaku;57(9):485-491, 2017 09 30.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:We investigated 17 adult cases (14 males and 3 females) of myalgia induced by human parechovirus type 3 (HPeV3) infection, treated during the summers of 2008, 2011, 2014, and 2016. The patients were aged between 21 and 50 years. The limbs and trunk of all patients were affected, and severe myalgia, muscle weakness, and decreased grip strength were observed. In addition to myalgia and muscle weakness, symptoms included fever in 14 (82%), upper respiratory inflammation in 8 (47%), gastroenteritis in 4 (24%), and scrotal pain in 4 (29% of males) patients. Tendon reflexes were preserved, and serum creatine kinase level increased in all but 1 patient. Spinal MRI was performed for 3 patients, with normal results. Musculoskeletal MRI scans showed abnormal signals in the femoral muscles in 2 of 5 patients. In a nerve conduction test, the frequency of F wave appearance in the median nerve was 40% or less in 5 of 9 patients, and repeater F waves were seen in 2 patients. Of these, 7 patients had infants in their families, and developed fever around the same time; they may have been infected by these infants. All patients recovered within 1-2 weeks. HPeV3 infection is characterized by severe myalgia, and is frequently observed in summer every 2-3 years.
[Mh] Termos MeSH primário: Parechovirus
Infecções por Picornaviridae/complicações
Infecções por Picornaviridae/virologia
Pleurodinia Epidêmica/etiologia
Pleurodinia Epidêmica/virologia
[Mh] Termos MeSH secundário: Adulto
Surtos de Doenças
Feminino
Febre
Seres Humanos
Lactente
Japão/epidemiologia
Angiografia por Ressonância Magnética
Masculino
Meia-Idade
Debilidade Muscular
Músculo Esquelético/diagnóstico por imagem
Condução Nervosa
Infecções por Picornaviridae/epidemiologia
Infecções por Picornaviridae/fisiopatologia
Pleurodinia Epidêmica/epidemiologia
Pleurodinia Epidêmica/fisiopatologia
Reflexo de Estiramento
Estações do Ano
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-001035



página 1 de 2633 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde