Base de dados : MEDLINE
Pesquisa : G07.265.755 [Categoria DeCS]
Referências encontradas : 20732 [refinar]
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  1 / 20732 MEDLINE  
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[PMID]:28463818
[Au] Autor:Rocchi L; Erro R; Antelmi E; Berardelli A; Tinazzi M; Liguori R; Bhatia K; Rothwell J
[Ad] Endereço:Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, WC1N 3BG London, United Kingdom; Department of Neurology and Psychiatry, University of Rome "Sapienza", Viale dell'Universita' 30, 00185 Rome, Italy. Electronic address: l.rocchi@ucl.ac
[Ti] Título:High frequency somatosensory stimulation increases sensori-motor inhibition and leads to perceptual improvement in healthy subjects.
[So] Source:Clin Neurophysiol;128(6):1015-1025, 2017 06.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: High frequency repetitive somatosensory stimulation (HF-RSS), which is a patterned electric stimulation applied to the skin through surface electrodes, improves two-point discrimination, somatosensory temporal discrimination threshold (STDT) and motor performance in humans. However, the mechanisms which underlie these changes are still unknown. In particular, we hypothesize that refinement of inhibition might be responsible for the improvement in spatial and temporal perception. METHODS: Fifteen healthy subjects underwent 45min of HF-RSS. Before and after the intervention several measures of inhibition in the primary somatosensory area (S1), such as paired-pulse somatosensory evoked potentials (pp-SEP), high-frequency oscillations (HFO), and STDT were tested, as well as tactile spatial acuity and short intracortical inhibition (SICI). RESULTS: HF-RSS increased inhibition in S1 tested by pp-SEP and HFO; these changes were correlated with improvement in STDT. HF-RSS also enhanced bumps detection, while there was no change in grating orientation test. Finally there was an increase in SICI, suggesting widespread changes in cortical sensorimotor interactions. CONCLUSIONS: These findings suggest that HF-RSS can improve spatial and temporal tactile abilities by increasing the effectiveness of inhibitory interactions in the somatosensory system. Moreover, HF-RSS induces changes in cortical sensorimotor interaction. SIGNIFICANCE: HF-RSS is a repetitive electric stimulation technique able to modify the effectiveness of inhibitory circuitry in the somatosensory system and primary motor cortex.
[Mh] Termos MeSH primário: Potenciais Somatossensoriais Evocados
Inibição Neural
Córtex Sensório-Motor/fisiologia
Percepção do Tato
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
Meia-Idade
Limiar Sensorial
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  2 / 20732 MEDLINE  
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[PMID]:28463113
[Au] Autor:Crevecoeur F; Kording KP
[Ad] Endereço:Institute of Information and Communication Technologies, Electronics and Applied Mathematics, Université catholique de Louvain, Louvain-la-Neuve, Belgium.
[Ti] Título:Saccadic suppression as a perceptual consequence of efficient sensorimotor estimation.
[So] Source:Elife;6, 2017 05 02.
[Is] ISSN:2050-084X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Humans perform saccadic eye movements two to three times per second. When doing so, the nervous system strongly suppresses sensory feedback for extended periods of time in comparison to movement time. Why does the brain discard so much visual information? Here we suggest that perceptual suppression may arise from efficient sensorimotor computations, assuming that perception and control are fundamentally linked. More precisely, we show theoretically that a Bayesian estimator should reduce the weight of sensory information around the time of saccades, as a result of signal dependent noise and of sensorimotor delays. Such reduction parallels the behavioral suppression occurring prior to and during saccades, and the reduction in neural responses to visual stimuli observed across the visual hierarchy. We suggest that saccadic suppression originates from efficient sensorimotor processing, indicating that the brain shares neural resources for perception and control.
[Mh] Termos MeSH primário: Encéfalo/fisiologia
Inibição Neural
Movimentos Sacádicos
Percepção Visual
[Mh] Termos MeSH secundário: Seres Humanos
Modelos Neurológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  3 / 20732 MEDLINE  
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[PMID]:29220646
[Au] Autor:Hu P; Fabyanic E; Kwon DY; Tang S; Zhou Z; Wu H
[Ad] Endereço:Department of Genetics, University of Pennsylvania, Philadelphia PA 19104, USA; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA 19104, USA.
[Ti] Título:Dissecting Cell-Type Composition and Activity-Dependent Transcriptional State in Mammalian Brains by Massively Parallel Single-Nucleus RNA-Seq.
[So] Source:Mol Cell;68(5):1006-1015.e7, 2017 Dec 07.
[Is] ISSN:1097-4164
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Massively parallel single-cell RNA sequencing can precisely resolve cellular diversity in a high-throughput manner at low cost, but unbiased isolation of intact single cells from complex tissues such as adult mammalian brains is challenging. Here, we integrate sucrose-gradient-assisted purification of nuclei with droplet microfluidics to develop a highly scalable single-nucleus RNA-seq approach (sNucDrop-seq), which is free of enzymatic dissociation and nucleus sorting. By profiling ∼18,000 nuclei isolated from cortical tissues of adult mice, we demonstrate that sNucDrop-seq not only accurately reveals neuronal and non-neuronal subtype composition with high sensitivity but also enables in-depth analysis of transient transcriptional states driven by neuronal activity, at single-cell resolution, in vivo.
[Mh] Termos MeSH primário: Núcleo Celular/metabolismo
Córtex Cerebral/metabolismo
Sequenciamento de Nucleotídeos em Larga Escala
Neurônios/metabolismo
RNA/genética
Convulsões/genética
Análise de Sequência de RNA/métodos
Análise de Célula Única/métodos
Transcrição Genética
[Mh] Termos MeSH secundário: Animais
Núcleo Celular/patologia
Centrifugação com Gradiente de Concentração
Córtex Cerebral/patologia
Córtex Cerebral/fisiopatologia
Modelos Animais de Doenças
Células-Tronco Embrionárias Humanas/metabolismo
Seres Humanos
Cinética
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Técnicas Analíticas Microfluídicas
Células NIH 3T3
Inibição Neural
Neurônios/patologia
Pentilenotetrazol
RNA/metabolismo
Convulsões/metabolismo
Convulsões/patologia
Convulsões/fisiopatologia
Transmissão Sináptica
Transfecção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
63231-63-0 (RNA); WM5Z385K7T (Pentylenetetrazole)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


  4 / 20732 MEDLINE  
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[PMID]:28451637
[Au] Autor:Sun Y; Grieco SF; Holmes TC; Xu X
[Ad] Endereço:Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697-1275.
[Ti] Título:Local and Long-Range Circuit Connections to Hilar Mossy Cells in the Dentate Gyrus.
[So] Source:eNeuro;4(2), 2017 Mar-Apr.
[Is] ISSN:2373-2822
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hilar mossy cells are the prominent glutamatergic cell type in the dentate hilus of the dentate gyrus (DG); they have been proposed to have critical roles in the DG network. To better understand how mossy cells contribute to DG function, we have applied new viral genetic and functional circuit mapping approaches to quantitatively map and compare local and long-range circuit connections of mossy cells and dentate granule cells in the mouse. The great majority of inputs to mossy cells consist of two parallel inputs from within the DG: an excitatory input pathway from dentate granule cells and an inhibitory input pathway from local DG inhibitory neurons. Mossy cells also receive a moderate degree of excitatory and inhibitory CA3 input from proximal CA3 subfields. Long range inputs to mossy cells are numerically sparse, and they are only identified readily from the medial septum and the septofimbrial nucleus. In comparison, dentate granule cells receive most of their inputs from the entorhinal cortex. The granule cells receive significant synaptic inputs from the hilus and the medial septum, and they also receive direct inputs from both distal and proximal CA3 subfields, which has been underdescribed in the existing literature. Our slice-based physiological mapping studies further supported the identified circuit connections of mossy cells and granule cells. Together, our data suggest that hilar mossy cells are major local circuit integrators and they exert modulation of the activity of dentate granule cells as well as the CA3 region through "back-projection" pathways.
[Mh] Termos MeSH primário: Hipocampo/citologia
Fibras Musgosas Hipocampais/anatomia & histologia
[Mh] Termos MeSH secundário: Potenciais de Ação
Animais
Neurônios Colinérgicos/citologia
Feminino
Neurônios GABAérgicos/citologia
Hipocampo/fisiologia
Masculino
Camundongos Endogâmicos C57BL
Fibras Musgosas Hipocampais/fisiologia
Inibição Neural
Vias Neurais/citologia
Vias Neurais/fisiologia
Técnicas de Rastreamento Neuroanatômico
Núcleos Septais/citologia
Sinapses
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  5 / 20732 MEDLINE  
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[PMID]:29252999
[Au] Autor:Yang S; Govindaiah G; Lee SH; Yang S; Cox CL
[Ad] Endereço:Department of Nano-bioengineering, Incheon National University, Incheon, Korea.
[Ti] Título:Distinct kinetics of inhibitory currents in thalamocortical neurons that arise from dendritic or axonal origin.
[So] Source:PLoS One;12(12):e0189690, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thalamocortical neurons in the dorsal lateral geniculate nucleus (dLGN) transfer visual information from retina to primary visual cortex. This information is modulated by inhibitory input arising from local interneurons and thalamic reticular nucleus (TRN) neurons, leading to alterations of receptive field properties of thalamocortical neurons. Local GABAergic interneurons provide two distinct synaptic outputs: axonal (F1 terminals) and dendritic (F2 terminals) onto dLGN thalamocortical neurons. By contrast, TRN neurons provide only axonal output (F1 terminals) onto dLGN thalamocortical neurons. It is unclear if GABAA receptor-mediated currents originating from F1 and F2 terminals have different characteristics. In the present study, we examined multiple characteristics (rise time, slope, halfwidth and decay τ) of GABAA receptor-mediated miniature inhibitory postsynaptic synaptic currents (mIPSCs) originating from F1 and F2 terminals. The mIPSCs arising from F2 terminals showed slower kinetics relative to those from F1 terminals. Such differential kinetics of GABAAR-mediated responses could be an important role in temporal coding of visual signals.
[Mh] Termos MeSH primário: Axônios/fisiologia
Córtex Cerebral/fisiologia
Dendritos/fisiologia
Neurônios/fisiologia
Tálamo/fisiologia
[Mh] Termos MeSH secundário: Animais
Eletrofisiologia
Feminino
Neurônios GABAérgicos/fisiologia
Corpos Geniculados/fisiologia
Potenciais Pós-Sinápticos Inibidores
Cinética
Masculino
Inibição Neural/fisiologia
Terminações Pré-Sinápticas/fisiologia
Domínios Proteicos
Ratos
Ratos Sprague-Dawley
Núcleos Talâmicos/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189690


  6 / 20732 MEDLINE  
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[PMID]:27770667
[Au] Autor:Lindberg PG; Térémetz M; Charron S; Kebir O; Saby A; Bendjemaa N; Lion S; Crépon B; Gaillard R; Oppenheim C; Krebs MO; Amado I
[Ad] Endereço:FR3636 CNRS, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; INSERM U894, Centre de Psychiatrie et Neurosciences, Paris, France; Institut de Psychiatrie-GDR 3557 de Psychiatrie, France. Electronic address: pavel.lindberg@inserm.fr.
[Ti] Título:Altered cortical processing of motor inhibition in schizophrenia.
[So] Source:Cortex;85:1-12, 2016 12.
[Is] ISSN:1973-8102
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Inhibition is considered a key mechanism in schizophrenia. Short-latency intracortical inhibition (SICI) in the motor cortex is reduced in schizophrenia and is considered to reflect locally deficient γ-aminobutyric acid (GABA)-ergic modulation. However, it remains unclear how SICI is modulated during motor inhibition and how it relates to neural processing in other cortical areas. Here we studied motor inhibition Stop signal task (SST) in stabilized patients with schizophrenia (N = 28), healthy siblings (N = 21) and healthy controls (n = 31) matched in general cognitive status and educational level. Transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI) were used to investigate neural correlates of motor inhibition. SST performance was similar in patients and controls. SICI was modulated by the task as expected in healthy controls and siblings but was reduced in patients with schizophrenia during inhibition despite equivalent motor inhibition performance. fMRI showed greater prefrontal and premotor activation during motor inhibition in schizophrenia. Task-related modulation of SICI was higher in subjects who showed less inhibition-related activity in pre-supplementary motor area (SMA) and cingulate motor area. An exploratory genetic analysis of selected markers of inhibition (GABRB2, GAD1, GRM1, and GRM3) did not explain task-related differences in SICI or cortical activation. In conclusion, this multimodal study provides direct evidence of a task-related deficiency in SICI modulation in schizophrenia likely reflecting deficient GABA-A related processing in motor cortex. Compensatory activation of premotor areas may explain similar motor inhibition in patients despite local deficits in intracortical processing. Task-related modulation of SICI may serve as a useful non-invasive GABAergic marker in development of therapeutic strategies in schizophrenia.
[Mh] Termos MeSH primário: Córtex Motor/fisiopatologia
Esquizofrenia/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Antipsicóticos/uso terapêutico
Mapeamento Encefálico
Eletromiografia/métodos
Potencial Evocado Motor/efeitos dos fármacos
Potencial Evocado Motor/fisiologia
Feminino
Seres Humanos
Masculino
Córtex Motor/efeitos dos fármacos
Inibição Neural/efeitos dos fármacos
Inibição Neural/fisiologia
Esquizofrenia/tratamento farmacológico
Estimulação Magnética Transcraniana/métodos
Ácido gama-Aminobutírico/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antipsychotic Agents); 56-12-2 (gamma-Aminobutyric Acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


  7 / 20732 MEDLINE  
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[PMID]:28747446
[Au] Autor:Benussi A; Di Lorenzo F; Dell'Era V; Cosseddu M; Alberici A; Caratozzolo S; Cotelli MS; Micheli A; Rozzini L; Depari A; Flammini A; Ponzo V; Martorana A; Caltagirone C; Padovani A; Koch G; Borroni B
[Ad] Endereço:From the Neurology Unit (A.B., V.D., M.C., A.A., S.C., L.R., A.P., B.B.), Department of Clinical and Experimental Sciences, University of Brescia; Non-Invasive Brain Stimulation Unit (F.D.L., V.P., A. Martorana, C.C., G.K.), IRCCS Santa Lucia Foundation; Stroke Unit (G.K.), Policlinico Tor Vergata,
[Ti] Título:Transcranial magnetic stimulation distinguishes Alzheimer disease from frontotemporal dementia.
[So] Source:Neurology;89(7):665-672, 2017 Aug 15.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine whether a transcranial magnetic stimulation (TMS) multiparadigm approach can be used to distinguish Alzheimer disease (AD) from frontotemporal dementia (FTD). METHODS: Paired-pulse TMS was used to investigate short-interval intracortical inhibition (SICI) and facilitation (ICF), long-interval intracortical inhibition, and short-latency afferent inhibition (SAI) to measure the activity of different intracortical circuits in patients with AD, patients with FTD, and healthy controls (HC). The primary outcome measures were sensitivity and specificity of TMS measures, derived from receiver operating curve analysis. RESULTS: A total of 175 participants met the inclusion criteria. We diagnosed 79 patients with AD, 64 patients with FTD, and 32 HC. We found that while patients with AD are characterized by a specific impairment of SAI, FTD shows a remarkable dysfunction of SICI-ICF intracortical circuits. With the use of the best indexes, TMS differentiated FTD from AD with a sensitivity of 91.8% and specificity of 88.6%, AD from HC with a sensitivity of 84.8% and specificity of 90.6%, and FTD from HC with a sensitivity of 90.2% and specificity of 78.1%. These results were confirmed in patients with mild disease. CONCLUSIONS: TMS is a noninvasive procedure that reliably distinguishes AD from FTD and HC and, if these findings are replicated in larger studies, could represent a useful additional diagnostic tool for clinical practice. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that TMS measures can distinguish patients with AD from those with FTD.
[Mh] Termos MeSH primário: Doença de Alzheimer/diagnóstico
Córtex Cerebral/fisiopatologia
Demência Frontotemporal/diagnóstico
Inibição Neural/fisiologia
Estimulação Magnética Transcraniana/métodos
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Doença de Alzheimer/fisiopatologia
Diagnóstico Diferencial
Feminino
Demência Frontotemporal/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Sensibilidade e Especificidade
Estimulação Magnética Transcraniana/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000004232


  8 / 20732 MEDLINE  
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[PMID]:29024654
[Au] Autor:Burke DA; Rotstein HG; Alvarez VA
[Ad] Endereço:Laboratory on Neurobiology of Compulsive Behaviors, Intramural Research Program, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA; Department of Neuroscience, Brown University, Providence, Providence, RI 02912, USA.
[Ti] Título:Striatal Local Circuitry: A New Framework for Lateral Inhibition.
[So] Source:Neuron;96(2):267-284, 2017 Oct 11.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This Perspective will examine the organization of intrastriatal circuitry, review recent findings in this area, and discuss how the pattern of connectivity between striatal neurons might give rise to the behaviorally observed synergism between the direct/indirect pathway neurons. The emphasis of this Perspective is on the underappreciated role of lateral inhibition between striatal projection cells in controlling neuronal firing and shaping the output of this circuit. We review some classic studies in combination with more recent anatomical and functional findings to lay out a framework for an updated model of the intrastriatal lateral inhibition, where we explore its contribution to the formation of functional units of processing and the integration and filtering of inputs to generate motor patterns and learned behaviors.
[Mh] Termos MeSH primário: Corpo Estriado/fisiologia
Lateralidade Funcional/fisiologia
Neurônios GABAérgicos/fisiologia
Rede Nervosa/fisiologia
Inibição Neural/fisiologia
[Mh] Termos MeSH secundário: Animais
Corpo Estriado/citologia
Seres Humanos
Rede Nervosa/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171022
[Lr] Data última revisão:
171022
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE


  9 / 20732 MEDLINE  
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[PMID]:28957678
[Au] Autor:Lee SC; Amir A; Haufler D; Pare D
[Ad] Endereço:Center for Molecular and Behavioral Neuroscience, 197 University Avenue, Rutgers University-Newark, Newark, NJ 07102, USA.
[Ti] Título:Differential Recruitment of Competing Valence-Related Amygdala Networks during Anxiety.
[So] Source:Neuron;96(1):81-88.e5, 2017 Sep 27.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The basolateral amygdala (BL) is involved in fear and anxiety, but it is currently unclear how the same network supports these two states. To address this question, we trained rats on appetitive and aversive conditioning in different contexts. Distinct groups of BL neurons displayed increased activity during appetitive (CS-R) versus aversive (CS-S) conditioned stimuli (R cells and S cells, respectively), and they were typically inhibited by the other CS. When the CS-S was presented in the safe context, rats entered a long-lasting, anxiety-like state characterized by increased inter-CS freezing and impaired reward seeking. During this state, a subset of BL cells ("state cells") showed sustained shifts in baseline activity whose time course matched that of the behavioral changes. Many state cells with increased firing rates were S cells, whereas R cells only included state cells with reduced firing rates. Thus, anxiety involves persistent activity changes that are differentially expressed by subsets of valence-specific BL neurons.
[Mh] Termos MeSH primário: Ansiedade/fisiopatologia
Complexo Nuclear Basolateral da Amígdala/fisiologia
[Mh] Termos MeSH secundário: Estimulação Acústica
Animais
Complexo Nuclear Basolateral da Amígdala/citologia
Condicionamento Clássico/fisiologia
Eletrochoque
Medo/fisiologia
Masculino
Inibição Neural/fisiologia
Neurônios/fisiologia
Ratos
Recompensa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE


  10 / 20732 MEDLINE  
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[PMID]:28957670
[Au] Autor:Yamamoto J; Tonegawa S
[Ad] Endereço:RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: jun.yamamoto@utsouthwestern.edu.
[Ti] Título:Direct Medial Entorhinal Cortex Input to Hippocampal CA1 Is Crucial for Extended Quiet Awake Replay.
[So] Source:Neuron;96(1):217-227.e4, 2017 Sep 27.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hippocampal replays have been demonstrated to play a crucial role in memory. Chains of ripples (ripple bursts) in CA1 have been reported to co-occur with long-range place cell sequence replays during the quiet awake state, but roles of neural inputs to CA1 in ripple bursts and replays are unknown. Here we show that ripple bursts in CA1 and medial entorhinal cortex (MEC) are temporally associated. An inhibition of MECIII input to CA1 during quiet awake reduced ripple bursts in CA1 and restricted the spatial coverage of replays to a shorter distance corresponding to single ripple events. The reduction did not occur with MECIII input inhibition during slow-wave sleep. Inhibition of CA3 activity suppressed ripples and replays in CA1 regardless of behavioral state. Thus, MECIII input to CA1 is crucial for ripple bursts and long-range replays specifically in quiet awake, whereas CA3 input is essential for both, regardless of behavioral state.
[Mh] Termos MeSH primário: Região CA1 Hipocampal/fisiologia
Córtex Entorrinal/fisiologia
Vigília/fisiologia
[Mh] Termos MeSH secundário: Animais
Região CA1 Hipocampal/citologia
Região CA3 Hipocampal/fisiologia
Córtex Entorrinal/citologia
Masculino
Aprendizagem em Labirinto/fisiologia
Camundongos
Camundongos Transgênicos
Inibição Neural/fisiologia
Vias Neurais/fisiologia
Células de Lugar/fisiologia
Sono/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde