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Pesquisa : G07.345 [Categoria DeCS]
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  1 / 1211 MEDLINE  
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[PMID]:28465333
[Au] Autor:Camp JG; Treutlein B
[Ad] Endereço:Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.
[Ti] Título:Human organomics: a fresh approach to understanding human development using single-cell transcriptomics.
[So] Source:Development;144(9):1584-1587, 2017 05 01.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Innovative methods designed to recapitulate human organogenesis from pluripotent stem cells provide a means to explore human developmental biology. New technologies to sequence and analyze single-cell transcriptomes can deconstruct these 'organoids' into constituent parts, and reconstruct lineage trajectories during cell differentiation. In this Spotlight article we summarize the different approaches to performing single-cell transcriptomics on organoids, and discuss the opportunities and challenges of applying these techniques to generate organ-level, mechanistic models of human development and disease. Together, these technologies will move past characterization to the prediction of human developmental and disease-related phenomena.
[Mh] Termos MeSH primário: Perfilação da Expressão Gênica/métodos
Crescimento e Desenvolvimento
Organoides/metabolismo
Análise de Célula Única/métodos
[Mh] Termos MeSH secundário: Linhagem da Célula
Seres Humanos
Organoides/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1242/dev.150458


  2 / 1211 MEDLINE  
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[PMID]:28923487
[Au] Autor:Oakley TH
[Ad] Endereço:Department of Ecology Evolution and Marine Biology, University of California, Santa Barbara, United States. Electronic address: oakley@lifesci.ucsb.edu.
[Ti] Título:Furcation and fusion: The phylogenetics of evolutionary novelty.
[So] Source:Dev Biol;431(1):69-76, 2017 11 01.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Novelty and innovation are fundamental yet relatively understudied concepts in evolution. We may study the history and provenance of novelty using phylogenetics, where key questions include when evolution occurs by tree-like branching and when it occurs by movement of distantly related parts in processes akin to horizontal transfer. Perfectly vertical inheritance, often an assumption of evolutionary trees, requires simultaneous co-duplication of the parts of a duplicating or speciating (processes I collectively call 'furcating') biological feature. However, simultaneous co-duplication of many parts usually requires variational processes that are rare. Therefore, instead of always being perfectly tree-like, evolution often involves events that incorporate or fuse more distantly related parts into new units during evolution, which herein I call 'fusion'. Exon shuffling, horizontal gene transfer, introgression, and co-option are such fusion processes at different levels of organization. The ubiquity of processes that fuse distantly related parts has wide ranging implications for the study of macroevolution. For one, the central metaphor of a tree of life will often be incomplete, to the point where we may consider a different metaphor, such as economic public goods, or a 'web of life'. Secondly, we often may need to expand commonly used phylogenetic models and methods, highlighting a need for an expansive toolkit for studying evolutionary history. Even though furcation - the splitting and individuation of biological features - does happen, fusion of distant parts may often be just as critical for the evolution of novelties, and must formally be incorporated into the metaphors, models, and visualization of evolutionary history. This will allow us to understand the timing, order of appearance, and diversification rates of developmental systems, including cell types, organs, behavior, and language, which very commonly evolve through co-option.
[Mh] Termos MeSH primário: Evolução Biológica
Filogenia
[Mh] Termos MeSH secundário: Animais
Evolução Molecular
Regulação da Expressão Gênica no Desenvolvimento
Redes Reguladoras de Genes
Crescimento e Desenvolvimento/genética
Modelos Genéticos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE


  3 / 1211 MEDLINE  
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[PMID]:28911170
[Au] Autor:Rebourcet D; Darbey A; Monteiro A; Soffientini U; Tsai YT; Handel I; Pitetti JL; Nef S; Smith LB; O'Shaughnessy PJ
[Ad] Endereço:Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow G61 1QH, United Kingdom.
[Ti] Título:Sertoli Cell Number Defines and Predicts Germ and Leydig Cell Population Sizes in the Adult Mouse Testis.
[So] Source:Endocrinology;158(9):2955-2969, 2017 Sep 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sertoli cells regulate differentiation and development of the testis and are essential for maintaining adult testis function. To model the effects of dysregulating Sertoli cell number during development or aging, we have used acute diphtheria toxin-mediated cell ablation to reduce Sertoli cell population size. Results show that the size of the Sertoli cell population that forms during development determines the number of germ cells and Leydig cells that will be present in the adult testis. Similarly, the number of germ cells and Leydig cells that can be maintained in the adult depends directly on the size of the adult Sertoli cell population. Finally, we have used linear modeling to generate predictive models of testis cell composition during development and in the adult based on the size of the Sertoli cell population. This study shows that at all ages the size of the Sertoli cell population is predictive of resulting testicular cell composition. A reduction in Sertoli cell number/proliferation at any age will therefore lead to a proportional decrease in germ cell and Leydig cell numbers, with likely consequential effects on fertility and health.
[Mh] Termos MeSH primário: Células Germinativas/citologia
Células Intersticiais do Testículo/citologia
Células de Sertoli/citologia
Testículo/citologia
[Mh] Termos MeSH secundário: Envelhecimento/fisiologia
Animais
Contagem de Células
Diferenciação Celular
Toxina Diftérica/genética
Genes Transgênicos Suicidas
Células Germinativas/fisiologia
Crescimento e Desenvolvimento/fisiologia
Células Intersticiais do Testículo/fisiologia
Masculino
Camundongos
Camundongos Transgênicos
Fragmentos de Peptídeos/genética
Células de Sertoli/fisiologia
Maturidade Sexual/fisiologia
Espermatogênese/fisiologia
Espermatozoides/citologia
Espermatozoides/fisiologia
Testículo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diphtheria Toxin); 0 (Peptide Fragments); 0 (diphtheria toxin fragment A)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00196


  4 / 1211 MEDLINE  
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[PMID]:28873413
[Au] Autor:Salt C; Morris PJ; German AJ; Wilson D; Lund EM; Cole TJ; Butterwick RF
[Ad] Endereço:WALTHAM Centre for Pet Nutrition, Mars Petcare, Waltham on the Wolds, Leicestershire, United Kingdom.
[Ti] Título:Growth standard charts for monitoring bodyweight in dogs of different sizes.
[So] Source:PLoS One;12(9):e0182064, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Limited information is available on what constitutes optimal growth in dogs. The primary aim of this study was to develop evidence-based growth standards for dogs, using retrospective analysis of bodyweight and age data from >6 million young dogs attending a large corporate network of primary care veterinary hospitals across the USA. Electronic medical records were used to generate bodyweight data from immature client-owned dogs, that were healthy and had remained in ideal body condition throughout the first 3 years of life. Growth centile curves were constructed using Generalised Additive Models for Location, Shape and Scale. Curves were displayed graphically as centile charts covering the age range 12 weeks to 2 years. Over 100 growth charts were modelled, specific to different combinations of breed, sex and neuter status. Neutering before 37 weeks was associated with a slight upward shift in growth trajectory, whilst neutering after 37 weeks was associated with a slight downward shift in growth trajectory. However, these shifts were small in comparison to inter-individual variability amongst dogs, suggesting that separate curves for neutered dogs were not needed. Five bodyweight categories were created to cover breeds up to 40kg, using both visual assessment and hierarchical cluster analysis of breed-specific growth curves. For 20/24 of the individual breed centile curves, agreement with curves for the corresponding bodyweight categories was good. For the remaining 4 breed curves, occasional deviation across centile lines was observed, but overall agreement was acceptable. This suggested that growth could be described using size categories rather than requiring curves for specific breeds. In the current study, a series of evidence-based growth standards have been developed to facilitate charting of bodyweight in healthy dogs. Additional studies are required to validate these standards and create a clinical tool for growth monitoring in pet dogs.
[Mh] Termos MeSH primário: Tamanho Corporal
Peso Corporal
Cães/crescimento & desenvolvimento
Gráficos de Crescimento
[Mh] Termos MeSH secundário: Animais
Cruzamento
Análise por Conglomerados
Bases de Dados como Assunto
Crescimento e Desenvolvimento
Modelos Teóricos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182064


  5 / 1211 MEDLINE  
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[PMID]:28827824
[Au] Autor:Monti R; Barozzi I; Osterwalder M; Lee E; Kato M; Garvin TH; Plajzer-Frick I; Pickle CS; Akiyama JA; Afzal V; Beerenwinkel N; Dickel DE; Visel A; Pennacchio LA
[Ad] Endereço:Lawrence Berkeley National Laboratory, Berkeley, California, United States of America.
[Ti] Título:Limb-Enhancer Genie: An accessible resource of accurate enhancer predictions in the developing limb.
[So] Source:PLoS Comput Biol;13(8):e1005720, 2017 Aug.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Epigenomic mapping of enhancer-associated chromatin modifications facilitates the genome-wide discovery of tissue-specific enhancers in vivo. However, reliance on single chromatin marks leads to high rates of false-positive predictions. More sophisticated, integrative methods have been described, but commonly suffer from limited accessibility to the resulting predictions and reduced biological interpretability. Here we present the Limb-Enhancer Genie (LEG), a collection of highly accurate, genome-wide predictions of enhancers in the developing limb, available through a user-friendly online interface. We predict limb enhancers using a combination of >50 published limb-specific datasets and clusters of evolutionarily conserved transcription factor binding sites, taking advantage of the patterns observed at previously in vivo validated elements. By combining different statistical models, our approach outperforms current state-of-the-art methods and provides interpretable measures of feature importance. Our results indicate that including a previously unappreciated score that quantifies tissue-specific nuclease accessibility significantly improves prediction performance. We demonstrate the utility of our approach through in vivo validation of newly predicted elements. Moreover, we describe general features that can guide the type of datasets to include when predicting tissue-specific enhancers genome-wide, while providing an accessible resource to the general biological community and facilitating the functional interpretation of genetic studies of limb malformations.
[Mh] Termos MeSH primário: Elementos Facilitadores Genéticos/genética
Extremidades/crescimento & desenvolvimento
Genômica/métodos
Crescimento e Desenvolvimento/genética
Software
[Mh] Termos MeSH secundário: Animais
Genoma/genética
Aprendizado de Máquina
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170917
[Lr] Data última revisão:
170917
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1005720


  6 / 1211 MEDLINE  
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[PMID]:28794168
[Au] Autor:Siebel C; Lendahl U
[Ad] Endereço:Department of Discovery Oncology, Genentech Inc., DNA Way, South San Francisco, California; and Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.
[Ti] Título:Notch Signaling in Development, Tissue Homeostasis, and Disease.
[So] Source:Physiol Rev;97(4):1235-1294, 2017 Oct 01.
[Is] ISSN:1522-1210
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-ß, Notch signaling occurs via cell-cell communication, where transmembrane ligands on one cell activate transmembrane receptors on a juxtaposed cell. Originally discovered through mutations in more than 100 yr ago, and with the first Notch gene cloned more than 30 yr ago, we are still gaining new insights into the broad effects of Notch signaling in organisms across the metazoan spectrum and its requirement for normal development of most organs in the body. In this review, we provide an overview of the Notch signaling mechanism at the molecular level and discuss how the pathway, which is architecturally quite simple, is able to engage in the control of cell fates in a broad variety of cell types. We discuss the current understanding of how Notch signaling can become derailed, either by direct mutations or by aberrant regulation, and the expanding spectrum of diseases and cancers that is a consequence of Notch dysregulation. Finally, we explore the emerging field of Notch in the control of tissue homeostasis, with examples from skin, liver, lung, intestine, and the vasculature.
[Mh] Termos MeSH primário: Comunicação Celular
Doença
Crescimento e Desenvolvimento
Homeostase
Receptores Notch/metabolismo
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Ligantes
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Ligands); 0 (Receptors, Notch)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1152/physrev.00005.2017


  7 / 1211 MEDLINE  
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[PMID]:28771493
[Au] Autor:Hess SY; Peerson JM; Becquey E; Abbeddou S; Ouédraogo CT; Somé JW; Yakes Jimenez E; Ouédraogo JB; Vosti SA; Rouamba N; Brown KH
[Ad] Endereço:Program in International and Community Nutrition, Department of Nutrition, University of California Davis, Davis, CA, United States of America.
[Ti] Título:Differing growth responses to nutritional supplements in neighboring health districts of Burkina Faso are likely due to benefits of small-quantity lipid-based nutrient supplements (LNS).
[So] Source:PLoS One;12(8):e0181770, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Of two community-based trials among young children in neighboring health districts of Burkina Faso, one found that small-quantity lipid-based nutrient supplements (LNS) increased child growth compared with a non-intervention control group, but zinc supplementation did not in the second study. OBJECTIVES: We explored whether the disparate growth outcomes were associated with differences in intervention components, household demographic variables, and/or children's morbidity. METHODS: Children in the LNS study received 20g LNS daily containing different amounts of zinc (LNS). Children in the zinc supplementation study received different zinc supplementation regimens (Z-Suppl). Children in both studies were visited weekly for morbidity surveillance. Free malaria and diarrhea treatment was provided by the field worker in the LNS study, and by a village-based community-health worker in the zinc study. Anthropometric assessments were repeated every 13-16 weeks. For the present analyses, study intervals of the two studies were matched by child age and month of enrollment. The changes in length-for-age z-score (LAZ) per interval were compared between LNS and Z-Suppl groups using mixed model ANOVA or ANCOVA. Covariates were added to the model in blocks, and adjusted differences between group means were estimated. RESULTS: Mean ages at enrollment of LNS (n = 1716) and Z-Suppl (n = 1720) were 9.4±0.4 and 10.1±2.7 months, respectively. The age-adjusted change in mean LAZ per interval declined less with LNS (-0.07±0.44) versus Z-Suppl (-0.21±0.43; p<0.0001). There was a significant group by interval interaction with the greatest difference found in 9-12 month old children (p<0.0001). Adjusting for demographic characteristics and morbidity did not reduce the observed differences by type of intervention, even though the morbidity burden was greater in the LNS group. CONCLUSIONS: Greater average physical growth in children who received LNS could not be explained by known cross-trial differences in baseline characteristics or morbidity burden, implying that the observed difference in growth response was partly due to LNS.
[Mh] Termos MeSH primário: Suplementos Nutricionais
Crescimento e Desenvolvimento/efeitos dos fármacos
Saúde
Lipídeos/química
[Mh] Termos MeSH secundário: Fatores Etários
Burkina Faso
Pré-Escolar
Feminino
Seres Humanos
Masculino
Distribuição Espacial da População
Zinco/química
Zinco/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Lipids); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181770


  8 / 1211 MEDLINE  
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[PMID]:28692656
[Au] Autor:Zhang X; Wu X; Chen W; Zhang Y; Jiang Y; Meng Q; Zhou Z
[Ad] Endereço:State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.
[Ti] Título:Growth performance and development of internal organ, and gastrointestinal tract of calf supplementation with calcium propionate at various stages of growth period.
[So] Source:PLoS One;12(7):e0179940, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To investigate the effects of calcium propionate (CaP) supplementation on performance, the development of the internal organ, and gastrointestinal tract of calves at various stages of growth period, 54 male Jersey calves (age = 7 ± 1 d, body weight(BW) = 23.1 ± 1.2 kg) were randomly allocated to three treatment groups. While control calves were fed basis dietary with no additives (0CaP), other treatment calves were fed basis dietary supplementation with CaP at 50 (5CaP) or 100 (10CaP) g kg-1 dry matter. The experiment lasted 160 d and was divided into three feeding stages: Stage 1 (d 0 to 30), Stage 2 (d 31 to 90), and Stage 3 (d 91 to160). Six calves from each group were randomly selected and slaughtered on days 30, 90, and 160 when at the conclusion of each experimental feeding stage. The BW of calves increased with 10CaP after feeding 90 d, whereas it increased with 5CaP and 10CaP at feeding 120d and 160d compared to 0CaP. The 10CaP group improved average daily gain (ADG) of calves at stage 2, and d120-160 of stage 3 compared with the 0CaP group. The ADG of 5CaP was greater than the 0CaP group only at 120-160 d of stage 3 compared with the 0CaP group. The results of feed efficiency were in agreed with ADG as no dry matter intake difference at all stages of growth period. The 10CaP treatment exhibited the greatest spleen weight among the treatment at the end of the experiment; the liver weight of the 5CaP and 10CaP calves at feeding 90 d and of the 10CaP calves at feeding 160 d and were greater than those of the 0CaP animals. The CaP at the tested doses increased the rumen weight after feeding 90d of Jersey calves, and also improved the development of intestine. In conclusion, dietary supplementation with calcium propionate at the tested doses caused a beneficial effect in the growth performance and gastrointestinal tract traits of Jersey calves, thus to add 10% CaP before feeding 90 days was better and 5% CaP supplementation was expected at the period for feeding 90 to160 d.
[Mh] Termos MeSH primário: Suplementos Nutricionais
Trato Gastrointestinal/crescimento & desenvolvimento
Crescimento e Desenvolvimento/efeitos dos fármacos
Organogênese/efeitos dos fármacos
Propionatos/farmacologia
[Mh] Termos MeSH secundário: Ração Animal
Animais
Peso Corporal/efeitos dos fármacos
Bovinos
Dieta/veterinária
Trato Gastrointestinal/efeitos dos fármacos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Propionates); 8AI80040KW (calcium propionate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179940


  9 / 1211 MEDLINE  
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[PMID]:28686853
[Au] Autor:Skraban CM; Wells CF; Markose P; Cho MT; Nesbitt AI; Au PYB; Begtrup A; Bernat JA; Bird LM; Cao K; de Brouwer APM; Denenberg EH; Douglas G; Gibson KM; Grand K; Goldenberg A; Innes AM; Juusola J; Kempers M; Kinning E; Markie DM; Owens MM; Payne K; Person R; Pfundt R; Stocco A; Turner CLS; Verbeek NE; Walsh LE; Warner TC; Wheeler PG; Wieczorek D; Wilkens AB; Zonneveld-Huijssoon E; Kleefstra T; Robertson SP; Santani A; van Gassen KLI; Deardorff MA; Deciphering Developmental Disorders Study
[Ad] Endereço:Division of Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
[Ti] Título:WDR26 Haploinsufficiency Causes a Recognizable Syndrome of Intellectual Disability, Seizures, Abnormal Gait, and Distinctive Facial Features.
[So] Source:Am J Hum Genet;101(1):139-148, 2017 Jul 06.
[Is] ISSN:1537-6605
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We report 15 individuals with de novo pathogenic variants in WDR26. Eleven of the individuals carry loss-of-function mutations, and four harbor missense substitutions. These 15 individuals comprise ten females and five males, and all have intellectual disability with delayed speech, a history of febrile and/or non-febrile seizures, and a wide-based, spastic, and/or stiff-legged gait. These subjects share a set of common facial features that include a prominent maxilla and upper lip that readily reveal the upper gingiva, widely spaced teeth, and a broad nasal tip. Together, these features comprise a recognizable facial phenotype. We compared these features with those of chromosome 1q41q42 microdeletion syndrome, which typically contains WDR26, and noted that clinical features are consistent between the two subsets, suggesting that haploinsufficiency of WDR26 contributes to the pathology of 1q41q42 microdeletion syndrome. Consistent with this, WDR26 loss-of-function single-nucleotide mutations identified in these subjects lead to nonsense-mediated decay with subsequent reduction of RNA expression and protein levels. We derived a structural model of WDR26 and note that missense variants identified in these individuals localize to highly conserved residues of this WD-40-repeat-containing protein. Given that WDR26 mutations have been identified in ∼1 in 2,000 of subjects in our clinical cohorts and that WDR26 might be poorly annotated in exome variant-interpretation pipelines, we would anticipate that this disorder could be more common than currently appreciated.
[Mh] Termos MeSH primário: Facies
Marcha/genética
Haploinsuficiência/genética
Deficiência Intelectual/genética
Proteínas/genética
Convulsões/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Sequência de Bases
Pré-Escolar
Deleção Cromossômica
Feminino
Crescimento e Desenvolvimento/genética
Seres Humanos
Deficiência Intelectual/complicações
Masculino
Mutação/genética
Proteínas/química
Estabilidade de RNA/genética
Convulsões/complicações
Síndrome
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proteins); 0 (WDR26 protein, human)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE


  10 / 1211 MEDLINE  
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[PMID]:28419148
[Au] Autor:Slusarczyk M; Starzynski J; Bernatowicz P
[Ad] Endereço:University of Warsaw, Faculty of Biology, Department of Hydrobiology at Biological and Chemical Research Centre, Warsaw, Poland.
[Ti] Título:How long to rest in unpredictably changing habitats?
[So] Source:PLoS One;12(4):e0175927, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the present study, we investigated the optimum length of prolonged dormancy (developmental arrest extending over favourable periods) of organisms under uncertain environmental conditions. We used an artificial life model to simulate the evolution of suspended development in the ontogenesis of organisms inhabiting unpredictably changing habitats. A virtual population of semelparous parthenogenetic individuals that varied in a duration of developmental arrest competed for limited resources. At a constant level of available resources, uninterrupted development was the superior life strategy. Once population fluctuations appeared (generated by the stochastic variability of available resources), temporal developmental arrest became more advantageous than continuous development. We did not observe the selection of the optimum length of dormancy, but rather the evolution of a diversified period of developmental arrest. The fittest organisms employed bet-hedging strategy and produced diversified dormant forms postponing development for a different number of generations (from 0 to several generations, in decreasing or equal proportions). The maximum length of suspended development increased asymptotically with increasing environmental variability and was inversely related to the mortality of dormant forms. The prolonged dormancy may appear beneficial not only in erratic habitats but also in seasonal ones that are exposed to long-term variability of environmental conditions during the growing seasons. In light of our simulations the phenomenon of very long diapause (VLD), lasting tens to thousands of generations, which is occasionally observed in ontogenesis of some living creatures, may not be explained by the benefits of bet-hedging revival strategies. We propose an alternative reasoning for the expression of VLD.
[Mh] Termos MeSH primário: Adaptação Fisiológica
Ecossistema
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Simulação por Computador
Crescimento e Desenvolvimento
Modelos Biológicos
Partenogênese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175927



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