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  1 / 17772 MEDLINE  
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[PMID]:28465725
[Au] Autor:McEwen LM; Morin AM; Edgar RD; MacIsaac JL; Jones MJ; Dow WH; Rosero-Bixby L; Kobor MS; Rehkopf DH
[Ad] Endereço:Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, 950 West 28th Ave, Vancouver, Canada.
[Ti] Título:Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region.
[So] Source:Epigenetics Chromatin;10:21, 2017.
[Is] ISSN:1756-8935
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The Nicoya Peninsula in Costa Rica has one of the highest old-age life expectancies in the world, but the underlying biological mechanisms of this longevity are not well understood. As DNA methylation is hypothesized to be a component of biological aging, we focused on this malleable epigenetic mark to determine its association with current residence in Nicoya versus elsewhere in Costa Rica. Examining a population's unique DNA methylation pattern allows us to differentiate hallmarks of longevity from individual stochastic variation. These differences may be characteristic of a combination of social, biological, and environmental contexts. METHODS: In a cross-sectional subsample of the Costa Rican Longevity and Healthy Aging Study, we compared whole blood DNA methylation profiles of residents from Nicoya ( = 48) and non-Nicoya (other Costa Rican regions,  = 47) using the Infinium HumanMethylation450 microarray. RESULTS: We observed a number of differences that may be markers of delayed aging, such as bioinformatically derived differential CD8+ T cell proportions. Additionally, both site- and region-specific analyses revealed DNA methylation patterns unique to Nicoyans. We also observed lower overall variability in DNA methylation in the Nicoyan population, another hallmark of younger biological age. CONCLUSIONS: Nicoyans represent an interesting group of individuals who may possess unique immune cell proportions as well as distinct differences in their epigenome, at the level of DNA methylation.
[Mh] Termos MeSH primário: Metilação de DNA
Longevidade/genética
Linfócitos/metabolismo
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Linfócitos T CD4-Positivos/citologia
Linfócitos T CD4-Positivos/metabolismo
Linfócitos T CD8-Positivos/citologia
Linfócitos T CD8-Positivos/metabolismo
Costa Rica
Ilhas de CpG
Estudos Transversais
DNA/química
DNA/isolamento & purificação
DNA/metabolismo
Epigenômica
Feminino
Seres Humanos
Linfócitos/citologia
Masculino
Meia-Idade
Células T Matadoras Naturais/citologia
Células T Matadoras Naturais/metabolismo
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
9007-49-2 (DNA)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180310
[Lr] Data última revisão:
180310
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s13072-017-0128-2


  2 / 17772 MEDLINE  
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[PMID]:29220518
[Au] Autor:Lin T; You Y; Zeng ZH; Lin S; Chen YX; Cai HJ; Zhao JW; Wei H
[Ad] Endereço:Institute of Plant Protection, Fujian Academy of Agriculture Sciences, China.
[Ti] Título:Temperature-Dependent Development of Oligota flavicornis (Coleoptera: Staphylinidae) Preying on Tetranychus cinnabarinus (Acarina: Tetranychidae).
[So] Source:J Econ Entomol;110(6):2334-2341, 2017 12 05.
[Is] ISSN:1938-291X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effect of nine constant temperatures on developmental time of Oligota flavicornis (Boisduval and Lacordaire) preying on Tetranychus cinnabarinus (Boisduval) (Acari: Tetranychidae) eggs was determined under laboratory conditions of 75 ± 5% RH and a 16:8 (L:D) h photoperiod. O. flavicornis survival rates were highest between 18 and 30°C, although O. flavicornis eggs developed successfully to adults at 12-32°C, and the developmental durations to adult at the seven temperatures (12, 15, 18, 20, 25, 30, and 32°C) were 114.41, 51.66, 33.45, 23.21, 13.43, 11.54, and 17.18 d, respectively. Two linear and seven nonlinear models (Logan-6 and Logan-10, Taylor, Lactin-1 and Lactin-2, and Brière-1 and Brière-2) were fit to the developmental rates of the immature predatory stages to estimate the thermal constant (K) and critical temperatures. The lower temperature threshold (T0) and K for the immature stages using the common linear model were 9.96°C and 225.73 degree-days and Ikemoto-Takai linear model were 11.01°C and 167.14 degree-days, respectively. The upper temperature threshold values estimated by the Logan-6 and Lactin-1 models were both 34.86°C. The T0 values estimated by the Brière-1 and Brière-2 models were 10.67 and 9.32°C for all immature stages, respectively, and the estimated optimal temperature according to the Brière-2 model was 29.59°C. Therefore, the two linear models and Brière-2 model estimates approximated the actual relationship between the temperature and developmental rate of immature O. flavicornis.
[Mh] Termos MeSH primário: Coleópteros/crescimento & desenvolvimento
Controle Biológico de Vetores
Comportamento Predatório
Tetranychidae
[Mh] Termos MeSH secundário: Animais
Coleópteros/fisiologia
Larva/crescimento & desenvolvimento
Larva/fisiologia
Modelos Lineares
Longevidade
Modelos Biológicos
Dinâmica não Linear
Pupa/crescimento & desenvolvimento
Pupa/fisiologia
Temperatura Ambiente
Tetranychidae/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1093/jee/tox259


  3 / 17772 MEDLINE  
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[PMID]:29020644
[Au] Autor:Pradhan A; Olsson PE; Jass J
[Ad] Endereço:Biology, the Life Science Center, School of Science and Technology, Örebro University, SE-701 82 Örebro, Sweden. Electronic address: ajay.pradhan@oru.se.
[Ti] Título:Di(2-ethylhexyl) phthalate and diethyl phthalate disrupt lipid metabolism, reduce fecundity and shortens lifespan of Caenorhabditis elegans.
[So] Source:Chemosphere;190:375-382, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The widespread use of phthalates is of major concern as they have adverse effects on many different physiological functions, including reproduction, metabolism and cell differentiation. The aim of this study was to compare the toxicity of the widely-used di (2-ethydlhexyl) phthalate (DEHP) with its substitute, diethyl phthalate (DEP). We analyzed the toxicity of these two phthalates using Caenorhabditis elegans as a model system. Gene expression analysis following exposure during the L1 to young adult stage showed that DEHP and DEP alter the expression of genes involved in lipid metabolism and stress response. Genes associated with lipid metabolism, including fasn-1, pod-2, fat-5, acs-6 and sbp-1, and vitellogenin were upregulated. Among the stress response genes, ced-1 wah-1, daf-21 and gst-4 were upregulated, while ctl-1, cdf-2 and the heat shock proteins (hsp-16.1, hsp-16.48 and sip-1) were downregulated. Lipid staining revealed that DEHP significantly increased lipid content following 1 µM exposure, however, DEP required 10 µM exposure to elicit an effect. Both DEHP and DEP reduced the fecundity at 1 µM concentration. Lifespan analysis indicated that DEHP and DEP reduced the average lifespan from 14 days in unexposed worms to 13 and 12 days, respectively. Expression of lifespan associated genes showed a correlation to shortened lifespan in the exposed groups. As reported previously, our data also indicates that the banned DEHP is toxic to C. elegans, however its substitute DEP has not been previously tested in this model organism and our data revealed that DEP is equally potent as DEHP in regulating C. elegans physiological functions.
[Mh] Termos MeSH primário: Caenorhabditis elegans/efeitos dos fármacos
Dietilexilftalato/toxicidade
Fertilidade/efeitos dos fármacos
Metabolismo dos Lipídeos/efeitos dos fármacos
Longevidade/efeitos dos fármacos
Ácidos Ftálicos/toxicidade
[Mh] Termos MeSH secundário: Animais
Caenorhabditis elegans/metabolismo
Caenorhabditis elegans/fisiologia
Dietilexilftalato/farmacologia
Proteínas de Choque Térmico/genética
Metabolismo dos Lipídeos/genética
Ácidos Ftálicos/farmacologia
Reprodução/efeitos dos fármacos
Vitelogeninas/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Heat-Shock Proteins); 0 (Phthalic Acids); 0 (Vitellogenins); 6O7F7IX66E (phthalic acid); C42K0PH13C (Diethylhexyl Phthalate); UF064M00AF (diethyl phthalate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE


  4 / 17772 MEDLINE  
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[PMID]:29428128
[Au] Autor:Tia N; Singh AK; Pandey P; Azad CS; Chaudhary P; Gambhir IS
[Ad] Endereço:Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
[Ti] Título:Role of Forkhead Box O (FOXO) transcription factor in aging and diseases.
[So] Source:Gene;648:97-105, 2018 Mar 30.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Fork head box O (FOXO) transcription factor is a key player in an evolutionarily conserved pathway. The mammalian FOXO family consists of FOXO1, 3, 4 and 6, are highly similar in their structure, function and regulation. To maintain optimum body function, the organisms have developed complex mechanisms for homeostasis. Importantly, it is well known that when these mechanisms dysregulate it results in the development of age-related disease. FOXO proteins are involved in a diverse cellular function and also have clinical significance including cell cycle arrest, cell differentiation, tumour suppression, DNA repair, longevity, diabetic complications, immunity, wound healing, regulation of metabolism and thus treatment of several types of diseases. By the combinations of post-translational modifications FOXO's serve as a 'molecular code' to sense external stimuli and recruit it as to specific regions of the genome and provide an integrated cellular response to changing physiological conditions. Akt/Protein kinase B a signaling pathway as a main regulator of FOXO to perform a diverse function in organisms. The present review summarizes the molecular and clinical aspects of FOXO transcription factor. And also elaborate the interaction of FOXO with the nucleosome remodelling complex to target genes, which is essential to cellular homeostasis.
[Mh] Termos MeSH primário: Envelhecimento/genética
Doença/genética
Fatores de Transcrição Forkhead/genética
Regulação da Expressão Gênica
[Mh] Termos MeSH secundário: Envelhecimento/metabolismo
Animais
Fenômenos Fisiológicos Celulares/genética
Fatores de Transcrição Forkhead/metabolismo
Seres Humanos
Longevidade/genética
Isoformas de Proteínas/genética
Isoformas de Proteínas/metabolismo
Transdução de Sinais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Forkhead Transcription Factors); 0 (Protein Isoforms)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180212
[St] Status:MEDLINE


  5 / 17772 MEDLINE  
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[PMID]:28451923
[Au] Autor:Tower J; Landis GN; Shen J; Choi R; Fan Y; Lee D; Song J
[Ad] Endereço:Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, 1050 Childs Way, RRI201, Los Angeles, CA, 90089-2910, USA. jtower@usc.edu.
[Ti] Título:Mifepristone/RU486 acts in Drosophila melanogaster females to counteract the life span-shortening and pro-inflammatory effects of male Sex Peptide.
[So] Source:Biogerontology;18(3):413-427, 2017 Jun.
[Is] ISSN:1573-6768
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Males with null mutation of Sex Peptide (SP) gene were compared to wild-type males for the ability to cause physiological changes in females that could be reversed by mifepristone. Males from wild-type strains decreased median female life span by average -51%. Feeding mifepristone increased life span of these females by average +106%. In contrast, SP-null males did not decrease female life span, and mifepristone increased median life span of these females by average +14%, which was equivalent to the effect of mifepristone in virgin females (average +16%). Expression of innate immune response transgenic reporter (Drosocin-GFP) was increased in females mated to wild-type males, and this expression was reduced by mifepristone. In contrast, SP-null males did not increase Drosocin-GFP reporter expression in the female. Similarly, mating increased endogenous microbial load, and this effect was reduced or absent in females fed mifepristone and in females mated to SP-null males; no loss of intestinal barrier integrity was detected using dye-leakage assay. Reduction of microbial load by treating adult flies with doxycycline reduced the effects of both mating and mifepristone on life span. Finally, mifepristone blocked the negative effect on life span caused by transgenic expression of SP in virgin females. The data support the conclusion that the majority of the life span-shortening, immune-suppressive and pro-inflammatory effects of mating are due to male SP, and demonstrate that mifepristone acts in females to counteract these effects of male SP.
[Mh] Termos MeSH primário: Proteínas de Drosophila/fisiologia
Inflamação/fisiopatologia
Longevidade/efeitos dos fármacos
Mifepristona/farmacologia
Peptídeos/fisiologia
[Mh] Termos MeSH secundário: Animais
Animais Geneticamente Modificados
Feminino
Proteínas de Fluorescência Verde/genética
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drosophila Proteins); 0 (Peptides); 0 (male accessory gland peptide, Drosophila); 147336-22-9 (Green Fluorescent Proteins); 320T6RNW1F (Mifepristone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s10522-017-9703-y


  6 / 17772 MEDLINE  
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[PMID]:27776915
[Au] Autor:Mendler M; Riedinger C; Schlotterer A; Volk N; Fleming T; Herzig S; Nawroth PP; Morcos M
[Ad] Endereço:Department of Medicine 1 and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. Electronic address: michael.mendler@med.uni-heidelberg.de.
[Ti] Título:Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan.
[So] Source:J Diabetes Complications;31(2):304-310, 2017 Feb.
[Is] ISSN:1873-460X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Glucose derived metabolism generates reactive metabolites affecting the neuronal system and lifespan in C. elegans. Here, the role of the insulin homologue ins-7 and its downstream effectors in the generation of high glucose induced neuronal damage and shortening of lifespan was studied. RESULTS: In C. elegans high glucose conditions induced the expression of the insulin homologue ins-7. Abrogating ins-7 under high glucose conditions in non-neuronal cells decreased reactive oxygen species (ROS)-formation and accumulation of methylglyoxal derived advanced glycation endproducts (AGEs), prevented structural neuronal damage and normalised head motility and lifespan. The restoration of lifespan by decreased ins-7 expression was dependent on the concerted action of sod-3 and glod-4 coding for the homologues of iron-manganese superoxide dismutase and glyoxalase 1, respectively. CONCLUSIONS: Under high glucose conditions mitochondria-mediated oxidative stress and glycation are downstream targets of ins-7. This impairs the neuronal system and longevity via a non-neuronal/neuronal crosstalk by affecting sod-3 and glod-4, thus giving further insight into the pathophysiology of diabetic complications.
[Mh] Termos MeSH primário: Proteínas de Caenorhabditis elegans/antagonistas & inibidores
Proteínas de Caenorhabditis elegans/metabolismo
Caenorhabditis elegans/metabolismo
Regulação da Expressão Gênica no Desenvolvimento
Glucose/envenenamento
Lactoilglutationa Liase/metabolismo
Estresse Oxidativo
Hormônios Peptídicos/antagonistas & inibidores
Superóxido Dismutase/metabolismo
[Mh] Termos MeSH secundário: Animais
Comportamento Animal
Caenorhabditis elegans/enzimologia
Caenorhabditis elegans/crescimento & desenvolvimento
Proteínas de Caenorhabditis elegans/agonistas
Proteínas de Caenorhabditis elegans/genética
Retroalimentação Fisiológica
Técnicas de Silenciamento de Genes
Técnicas de Inativação de Genes
Produtos Finais de Glicação Avançada/metabolismo
Lactoilglutationa Liase/antagonistas & inibidores
Lactoilglutationa Liase/genética
Longevidade
Mutação
Neuroproteção
Concentração Osmolar
Hormônios Peptídicos/agonistas
Hormônios Peptídicos/genética
Hormônios Peptídicos/metabolismo
Interferência de RNA
Espécies Reativas de Oxigênio/metabolismo
Superóxido Dismutase/antagonistas & inibidores
Superóxido Dismutase/genética
Análise de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caenorhabditis elegans Proteins); 0 (Glycation End Products, Advanced); 0 (Ins-7 protein, C elegans); 0 (Peptide Hormones); 0 (Reactive Oxygen Species); EC 1.15.1.1 (Sod-3 protein, C elegans); EC 1.15.1.1 (Superoxide Dismutase); EC 4.4.1.5 (Lactoylglutathione Lyase); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  7 / 17772 MEDLINE  
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[PMID]:29251851
[Au] Autor:Kumbar SM; Lad SB
[Ti] Título:Estimation of age and longevity of freshwater fish Salmophasia balookee from otoliths, scales and vertebrae.
[So] Source:J Environ Biol;37(5):943-7, 2016 09.
[Is] ISSN:0254-8704
[Cp] País de publicação:India
[La] Idioma:eng
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Escamas de Animais/crescimento & desenvolvimento
Cyprinidae/fisiologia
Longevidade/fisiologia
Membrana dos Otólitos/crescimento & desenvolvimento
Coluna Vertebral/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Coluna Vertebral/crescimento & desenvolvimento
[Pt] Tipo de publicação:RESEARCH SUPPORT, NON-U.S. GOV'T; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


  8 / 17772 MEDLINE  
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[PMID]:28744878
[Au] Autor:King AM; Kirkwood TBL; Shanley DP
[Ad] Endereço:Institute for Cellular and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne NE4 5PL, United Kingdom.
[Ti] Título:Explaining sex differences in lifespan in terms of optimal energy allocation in the baboon.
[So] Source:Evolution;71(10):2280-2297, 2017 10.
[Is] ISSN:1558-5646
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We provide a quantitative test of the hypothesis that sex role specialization may account for sex differences in lifespan in baboons if such specialization causes the dependency of fitness upon longevity, and consequently the optimal resolution to an energetic trade-off between somatic maintenance and other physiological functions, to differ between males and females. We present a model in which females provide all offspring care and males compete for access to reproductive females and in which the partitioning of available energy between the competing fitness-enhancing functions of growth, maintenance, and reproduction is modeled as a dynamic behavioral game, with the optimal decision for each individual depending upon his/her state and the behavior of other members of the population. Our model replicates the sexual dimorphism in body size and sex differences in longevity and reproductive scheduling seen in natural populations of baboons. We show that this outcome is generally robust to perturbations in model parameters, an important finding given that the same behavior is seen across multiple populations and species in the wild. This supports the idea that sex differences in longevity result from differences in the value of somatic maintenance relative to other fitness-enhancing functions in keeping with the disposable soma theory.
[Mh] Termos MeSH primário: Longevidade
Modelos Genéticos
Papio/genética
[Mh] Termos MeSH secundário: Animais
Tamanho Corporal/genética
Evolução Molecular
Feminino
Aptidão Genética
Masculino
Papio/crescimento & desenvolvimento
Papio/fisiologia
Reprodução
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1111/evo.13316


  9 / 17772 MEDLINE  
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[PMID]:29381014
[Au] Autor:Fefelova YA; Sergeeva EY; Novikova LV; Klimina GM
[Ti] Título:[The influence of diets on metabolic processes associated with sirtuin1].
[So] Source:Vopr Pitan;85(4):5-13, 2016.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Over the last decade the investigations of the sirtuin protein family have become one of the research priorities. It is connected with the fact that sirtuins play an important role as regulators of cell homeostasis in mammals. Sirtuins can regulate metabolism by the influence on some processes in CNS, liver, pancreas, musles, adipose tissue. It emphasizes the importance of sirtuins in the development of heart diseases, cancer, metabolic syndrome, neurodegenerative and some other diseases. Stress factors in particular calorie restriction alter sirtuins activity, that leads to some significant alterations of intracellular processes: activation of reparation processes, increase of DNA stability, elevation of metabolic rate and the lifespan of cells. In this review, we focus our attention on the influence of calorie restriction on metabolic alterations associated with regulatory role of sirtuin1. Sirtuin1 plays a leading role in regulation of cell homeostasis by controlling some important processes, such as gene transcription, cell differentiation, stress reaction, inflammation, apoptosis, circadian rhythms and life expectancy. We touch briefly on the connection between some alterations of diet and the development of stress reaction and inflammation. In the review the metabolic alterations in liver, pancreas, adipose tissue and central regulatory role of sirtuinl in hypothalamic-pituitary-adrenal axis connected with calorie restriction are discussed. Sirtuin1 can be a messenger of some effects of calorie restriction on organism, acting as a cell energy sensor. Thus, sirtuinl plays a central role in control and modulation of metabolic processes under alterations of diet. Having been one of the most important regulator of homeostasis, sirtuinl can be a key element of regulation. The influence on this element gives the opportunities of regulation of metabolism, calorie restriction effects and creation of new pathogenical methods of treatment.
[Mh] Termos MeSH primário: Dieta
Sirtuína 1/metabolismo
[Mh] Termos MeSH secundário: Animais
Apoptose
Diferenciação Celular
Ritmo Circadiano
Reparo do DNA
Instabilidade Genômica
Seres Humanos
Sistema Hipotálamo-Hipofisário/metabolismo
Inflamação
Longevidade
Especificidade de Órgãos
Sistema Hipófise-Suprarrenal/metabolismo
Sirtuína 1/genética
Estresse Fisiológico
Transcrição Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
EC 3.5.1.- (SIRT1 protein, human); EC 3.5.1.- (Sirtuin 1)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE


  10 / 17772 MEDLINE  
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[PMID]:29217196
[Au] Autor:Kim M; Subramanian M; Cho YH; Kim GH; Lee E; Park JJ
[Ad] Endereço:Department of Preventive Medicine, College of Medicine, Korea University, 73 Inchon-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
[Ti] Título:Short-term exposure to dim light at night disrupts rhythmic behaviors and causes neurodegeneration in fly models of tauopathy and Alzheimer's disease.
[So] Source:Biochem Biophys Res Commun;495(2):1722-1729, 2018 01 08.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The accumulation and aggregation of phosphorylated tau proteins in the brain are the hallmarks for the onset of Alzheimer's disease (AD). In addition, disruptions in circadian rhythms (CRs) with altered sleep-wake cycles, dysregulation of locomotion, and increased memory defects have been reported in patients with AD. Drosophila flies that have an overexpression of human tau protein in neurons exhibit most of the symptoms of human patients with AD, including locomotion defects and neurodegeneration. Using the fly model for tauopathy/AD, we investigated the effects of an exposure to dim light at night on AD symptoms. We used a light intensity of 10 lux, which is considered the lower limit of light pollution in many countries. After the tauopathy flies were exposed to the dim light at night for 3 days, the flies showed disrupted CRs, altered sleep-wake cycles due to increased pTau proteins and neurodegeneration, in the brains of the AD flies. The results indicate that the nighttime exposure of tauopathy/AD model Drosophila flies to dim light disrupted CR and sleep-wake behavior and promoted neurodegeneration.
[Mh] Termos MeSH primário: Doença de Alzheimer/etiologia
Ritmo Circadiano/efeitos da radiação
Degeneração Neural/etiologia
Tauopatias/etiologia
[Mh] Termos MeSH secundário: Animais
Animais Geneticamente Modificados
Encéfalo/metabolismo
Encéfalo/patologia
Ritmo Circadiano/fisiologia
Modelos Animais de Doenças
Drosophila melanogaster/fisiologia
Drosophila melanogaster/efeitos da radiação
Seres Humanos
Luz
Longevidade/genética
Longevidade/fisiologia
Masculino
Proteínas Mutantes/genética
Proteínas Mutantes/metabolismo
Degeneração Neural/metabolismo
Degeneração Neural/patologia
Fotoperíodo
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Transtornos do Sono-Vigília/etiologia
Proteínas tau/genética
Proteínas tau/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (MAPT protein, human); 0 (Mutant Proteins); 0 (Recombinant Proteins); 0 (tau Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE



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