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[PMID]:28457982
[Au] Autor:Joki A; Mäkelä J; Fogelholm M
[Ad] Endereço:Department of Food and Environmental Sciences, University of Helsinki, P.O. Box 66, Building: 2029, Helsingin Yliopisto, Finland. Electronic address: anu.joki@helsinki.fi.
[Ti] Título:Permissive flexibility in successful lifelong weight management: A qualitative study among Finnish men and women.
[So] Source:Appetite;116:157-163, 2017 09 01.
[Is] ISSN:1095-8304
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Maintaining normal weight in the current obesogenic environment is a challenge. However, some people can do it. More insight is needed to understand how and why some people succeed in long-term weight maintenance. This study uses a rare, qualitative approach by describing the thoughts of successful weight management and self-perceived requirements for success in weight maintenance. We interviewed 39 individuals who have maintained normal weight for their entire lives (men and women). The content analysis revealed a main theme: flexible, permissive and conscious self-regulation, which was divided into two subthemes (eating-related behavior and weight-related behavior). The informants reported certain routines that supported their weight management: regular eating, sufficient meal sizes, eating in response to hunger, healthy and vegetable-rich diet along with moderate feasting and flexible eating restriction. Flexibility in routines allowed freedom in their eating behavior. In addition, informants regarded themselves as physically active, and they enjoyed regular exercise. Regular weighing was generally considered unnecessary. Normal weight was regarded as a valuable and worthwhile issue, and most of the informants worked to keep their weight stable. Although the perceived workload varied among informants, the weight management strategies were similar. It was crucial to be conscious of the balance between eating and energy consumption. Further, flexibility characterized their behavior and was the basis of successful weight management. Women were more aware of weight control practices and knowledge than men, but otherwise, women and men reported similar weight management methods and attitudes. In conclusion, the interviewees who have maintained the normal weight had created a personal weight-management support environment where weight management was a lifestyle.
[Mh] Termos MeSH primário: Adaptação Psicológica
Manutenção do Peso Corporal
Exercício
Estilo de Vida Saudável
Modelos Psicológicos
Cooperação do Paciente
[Mh] Termos MeSH secundário: Adulto
Idoso
Regulação do Apetite
Índice de Massa Corporal
Exercício/psicologia
Comportamento Alimentar/psicologia
Feminino
Finlândia
Conhecimentos, Atitudes e Prática em Saúde
Seres Humanos
Masculino
Refeições
Meia-Idade
Cooperação do Paciente/psicologia
Pesquisa Qualitativa
Autorrelato
Autocontrole/psicologia
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:28747328
[Au] Autor:Christensen P; Henriksen M; Bartels EM; Leeds AR; Meinert Larsen T; Gudbergsen H; Riecke BF; Astrup A; Heitmann BL; Boesen M; Christensen R; Bliddal H
[Ad] Endereço:The Parker Institute and Departments of.
[Ti] Título:Long-term weight-loss maintenance in obese patients with knee osteoarthritis: a randomized trial.
[So] Source:Am J Clin Nutr;106(3):755-763, 2017 Sep.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A formula low-energy diet (LED) reduces weight effectively in obese patients with knee osteoarthritis, but the role of LED in long-term weight-loss maintenance is unclear. We aimed to determine the effect of intermittent LED compared with daily meal replacements on weight-loss maintenance and number of knee replacements over 3 y. The design was a randomized trial with participants aged >50 y who had knee osteoarthritis and a body mass index [BMI (in kg/m )] ≥30. Participants were recruited from the osteoarthritis outpatient clinic at Copenhagen University Hospital in Frederiksberg, Denmark; they had previously completed a 68-wk lifestyle intervention trial and achieved an average weight loss of 10.5 kg (10% of initial body weight). Participants were randomly assigned to either the intermittent treatment (IN) group with LED for 5 wk every 4 mo for 3 y or to daily meal replacements of 1-2 meals for 3 y [regular (RE) group]. Attention by dietitians and the amount of formula products were similar. Primary outcomes were changes in body weight and proportion of participants receiving knee replacements. Outcomes were analyzed on the intention-to-treat-population with the use of baseline-carried-forward imputation for missing data. A total of 153 participants (means ± SDs: BMI: 33.3 ± 4.6; age: 63.8 ± 6.3 y; 83% women) were recruited between June and December 2009 and randomly assigned to the IN ( = 76) or RE ( = 77) group. A total of 53 and 56 participants, respectively, completed the trial. Weight increased by 0.68 and 1.75 kg in the IN and RE groups, respectively (mean difference: -1.06 kg; 95% CI: -2.75, 0.63 kg; = 0.22). Alloplasty rates were low and did not differ (IN group: 8 of 76 participants; RE group: 12 of 77 participants; = 0.35). After a mean 10% weight-loss and 1-y maintenance, additional use of daily meal replacements or intermittent LED resulted in weight-loss maintenance for 3 y. These results challenge the commonly held assumption that weight regain in the long term is inevitable. This trial was registered at clinicaltrials.gov as NCT00938808.
[Mh] Termos MeSH primário: Índice de Massa Corporal
Manutenção do Peso Corporal
Restrição Calórica
Dieta Redutora/métodos
Ingestão de Energia
Obesidade/dietoterapia
Osteoartrite do Joelho/complicações
[Mh] Termos MeSH secundário: Idoso
Artroplastia do Joelho
Feminino
Alimentos Formulados
Seres Humanos
Estilo de Vida
Masculino
Refeições
Meia-Idade
Osteoartrite do Joelho/cirurgia
Ganho de Peso
Perda de Peso
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180124
[Lr] Data última revisão:
180124
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170728
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.117.158543


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[PMID]:28793995
[Au] Autor:Armenise C; Lefebvre G; Carayol J; Bonnel S; Bolton J; Di Cara A; Gheldof N; Descombes P; Langin D; Saris WH; Astrup A; Hager J; Viguerie N; Valsesia A
[Ad] Endereço:QuartzBio SA, Geneva, Switzerland.
[Ti] Título:Transcriptome profiling from adipose tissue during a low-calorie diet reveals predictors of weight and glycemic outcomes in obese, nondiabetic subjects.
[So] Source:Am J Clin Nutr;106(3):736-746, 2017 Sep.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A low-calorie diet (LCD) reduces fat mass excess, improves insulin sensitivity, and alters adipose tissue (AT) gene expression, yet the relation with clinical outcomes remains unclear. We evaluated AT transcriptome alterations during an LCD and the association with weight and glycemic outcomes both at LCD termination and 6 mo after the LCD. Using RNA sequencing (RNAseq), we analyzed transcriptome changes in AT from 191 obese, nondiabetic patients within a multicenter, controlled dietary intervention. Expression changes were associated with outcomes after an 8-wk LCD (800-1000 kcal/d) and 6 mo after the LCD. Results were validated by using quantitative reverse transcriptase-polymerase chain reaction in 350 subjects from the same cohort. Statistical models were constructed to classify weight maintainers or glycemic improvers. With RNAseq analyses, we identified 1173 genes that were differentially expressed after the LCD, of which 350 and 33 were associated with changes in body mass index (BMI; in kg/m ) and Matsuda index values, respectively, whereas 29 genes were associated with both endpoints. Pathway analyses highlighted enrichment in lipid and glucose metabolism. Classification models were constructed to identify weight maintainers. A model based on clinical baseline variables could not achieve any classification (validation AUC: 0.50; 95% CI: 0.36, 0.64). However, clinical changes during the LCD yielded better performance of the model (AUC: 0.73; 95% CI: 0.60, 0.87]). Adding baseline expression to this model improved the performance significantly (AUC: 0.87; 95% CI: 0.77, 0.96; Delong's = 0.012). Similar analyses were performed to classify subjects with good glycemic improvements. Baseline- and LCD-based clinical models yielded similar performance (best AUC: 0.73; 95% CI: 0.60, 0.86). The addition of expression changes during the LCD improved the performance substantially (AUC: 0.80; 95% CI: 0.69, 0.92; = 0.058). This study investigated AT transcriptome alterations after an LCD in a large cohort of obese, nondiabetic patients. Gene expression combined with clinical variables enabled us to distinguish weight and glycemic responders from nonresponders. These potential biomarkers may help clinicians understand intersubject variability and better predict the success of dietary interventions. This trial was registered at clinicaltrials.gov as NCT00390637.
[Mh] Termos MeSH primário: Tecido Adiposo/metabolismo
Glicemia/metabolismo
Restrição Calórica
Dieta Redutora
Resistência à Insulina
Obesidade/genética
Transcriptoma
[Mh] Termos MeSH secundário: Adulto
Área Sob a Curva
Biomarcadores/metabolismo
Peso Corporal
Manutenção do Peso Corporal
Feminino
Perfilação da Expressão Gênica
Seres Humanos
Masculino
Obesidade/metabolismo
Obesidade/terapia
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Perda de Peso/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biomarkers); 0 (Blood Glucose)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.117.156216


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[PMID]:28679554
[Au] Autor:Kjølbæk L; Sørensen LB; Søndertoft NB; Rasmussen CK; Lorenzen JK; Serena A; Astrup A; Larsen LH
[Ad] Endereço:Department of Nutrition, Exercise and Sports, Faculty of Science, and louisekjoelbaek@nexs.ku.dk.
[Ti] Título:Protein supplements after weight loss do not improve weight maintenance compared with recommended dietary protein intake despite beneficial effects on appetite sensation and energy expenditure: a randomized, controlled, double-blinded trial.
[So] Source:Am J Clin Nutr;106(2):684-697, 2017 Aug.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:: High-protein diets increase weight loss (WL) during energy restriction; therefore, it has been suggested that additional protein intake may improve weight maintenance (WM) after WL. We investigated the effect of protein supplements from either whey with or without calcium or soy on WM success after WL compared with that of a control. In a randomized, controlled, double-blinded trial, 220 participants aged 18-60 y with body mass index (in kg/m ) from 27.6 to 40.4 were included. The study was initiated with an 8-wk WL period followed by a 24-wk WM period. During WM, participants consumed the following isocaloric supplements (45-48 g/d): whey and calcium (whey+), whey, soy, or maltodextrin (control). Data were collected at baseline, before WM, and after WM (weeks 0, 8, and 32, respectively) and included body composition, blood biochemistry, and blood pressure. Meal tests were performed to investigate diet-induced-thermogenesis (DIT) and appetite sensation. Compliance was tested by 24-h urinary nitrogen excretion. A total of 151 participants completed the WM period. The control and 3 protein supplements did not result in different mean ± SD weight regains (whey+: 2.19 ± 4.6 kg; whey: 2.01 ± 4.6 kg; soy: 1.76 ± 4.7 kg; and control: 2.23 ± 3.8 kg; = 0.96), fat mass regains (whey+: 0.46 ± 4.5 kg; whey: 0.11 ± 4.1 kg; soy: 0.15 ± 4.1 kg; and control: 0.54 ± 3.3 kg; = 0.96), or improvements in lean body mass (whey+: 1.87 ± 1.7 kg; whey: 1.94 ± 1.3 kg; soy: 1.58 ± 1.4 kg; and control: 1.74 ± 1.4 kg; = 0.50) during WM. Changes in blood pressure and blood biochemistry were not different between groups. Compared with the control, protein supplementation resulted in higher DIT (∼30 kJ/2.5 h) and resting energy expenditure (243 kJ/d) and an anorexigenic appetite-sensation profile. Protein supplementation does not result in improved WM success, or blood biochemistry after WL compared with the effects of normal dietary protein intake (0.8-1.0 g · kg · d ). This trial was registered at clinicaltrials.gov as NCT01561131.
[Mh] Termos MeSH primário: Apetite/efeitos dos fármacos
Manutenção do Peso Corporal/fisiologia
Proteínas na Dieta/farmacologia
Suplementos Nutricionais
Metabolismo Energético/efeitos dos fármacos
Obesidade
Perda de Peso/fisiologia
[Mh] Termos MeSH secundário: Tecido Adiposo/metabolismo
Adulto
Composição Corporal
Compartimentos de Líquidos Corporais/metabolismo
Índice de Massa Corporal
Cálcio na Dieta/farmacologia
Proteínas na Dieta/administração & dosagem
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Refeições
Meia-Idade
Obesidade/dietoterapia
Sobrepeso/dietoterapia
Recomendações Nutricionais
Proteínas de Soja/farmacologia
Termogênese/efeitos dos fármacos
Proteínas do Soro do Leite/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Calcium, Dietary); 0 (Dietary Proteins); 0 (Soybean Proteins); 0 (Whey Proteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.115.129528


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[PMID]:28679551
[Au] Autor:Hjorth MF; Ritz C; Blaak EE; Saris WH; Langin D; Poulsen SK; Larsen TM; Sørensen TI; Zohar Y; Astrup A
[Ad] Endereço:Department of Nutrition, Exercise and Sports, Faculty of Sciences, madsfiil@nexs.ku.dk.
[Ti] Título:Pretreatment fasting plasma glucose and insulin modify dietary weight loss success: results from 3 randomized clinical trials.
[So] Source:Am J Clin Nutr;106(2):499-505, 2017 Aug.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Which diet is optimal for weight loss and maintenance remains controversial and implies that no diet fits all patients. We studied concentrations of fasting plasma glucose (FPG) and fasting insulin (FI) as prognostic markers for successful weight loss and maintenance through diets with different glycemic loads or different fiber and whole-grain content, assessed in 3 randomized trials of overweight participants. After an 8-wk weight loss, participants in the DiOGenes (Diet, Obesity, and Genes) trial consumed ad libitum for 26 wk a diet with either a high or a low glycemic load. Participants in the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) Supermarket intervention (SHOPUS) trial consumed ad libitum for 26 wk the New Nordic Diet, which is high in fiber and whole grains, or a control diet. Participants in the NUGENOB (Nutrient-Gene Interactions in Human Obesity) trial consumed a hypocaloric low-fat and high-carbohydrate or a high-fat and low-carbohydrate diet for 10 wk. On the basis of FPG before treatment, participants were categorized as normoglycemic (FPG <5.6 mmol/L), prediabetic (FPG 5.6-6.9 mmol/L), or diabetic (FPG ≥7.0 mmol/L). Modifications of the dietary effects of FPG and FI before treatment were examined with linear mixed models. In the DiOGenes trial, prediabetic individuals regained a mean of 5.83 kg (95% CI: 3.34, 8.32 kg; < 0.001) more on the high- than on the low-glycemic load diet, whereas normoglycemic individuals regained a mean of 1.44 kg (95% CI: 0.48, 2.41 kg; = 0.003) more [mean group difference: 4.39 kg (95% CI: 1.76, 7.02 kg); = 0.001]. In SHOPUS, prediabetic individuals lost a mean of 6.04 kg (95% CI: 4.05, 8.02 kg; < 0.001) more on the New Nordic Diet than on the control diet, whereas normoglycemic individuals lost a mean of 2.20 kg (95% CI: 1.21, 3.18 kg; < 0.001) more [mean group difference: 3.84 kg (95% CI: 1.62, 6.06 kg); = 0.001]. In NUGENOB, diabetic individuals lost a mean of 2.04 kg (95% CI: -0.20, 4.28 kg; = 0.07) more on the high-fat and low-carbohydrate diet than on the low-fat and high-carbohydrate diet, whereas normoglycemic individuals lost a mean of 0.43 kg (95% CI: 0.03, 0.83 kg; = 0.03) more on the low-fat and high-carbohydrate diet [mean group difference: 2.47 kg (95% CI: 0.20, 4.75 kg); = 0.03]. The addition of FI strengthened these associations. Elevated FPG before treatment indicates success with dietary weight loss and maintenance among overweight patients consuming diets with a low glycemic load or with large amounts of fiber and whole grains. These trials were registered at clinicaltrials.gov as NCT00390637 (DiOGenes) and NCT01195610 (SHOPUS), and at ISRNCT.com as ISRCTN25867281 (NUGENOB).
[Mh] Termos MeSH primário: Glicemia/metabolismo
Manutenção do Peso Corporal/fisiologia
Diabetes Mellitus/sangue
Comportamento Alimentar
Insulina/sangue
Obesidade/dietoterapia
Perda de Peso/fisiologia
[Mh] Termos MeSH secundário: Adulto
Dieta Redutora
Fibras na Dieta
Ingestão de Energia
Feminino
Carga Glicêmica
Seres Humanos
Masculino
Meia-Idade
Obesidade/sangue
Obesidade/complicações
Grãos Integrais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Dietary Fiber); 0 (Insulin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.117.155200


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[PMID]:28406437
[Au] Autor:Maresch CC; Petry SF; Theis S; Bosy-Westphal A; Linn T
[Ad] Endereço:Clinical Research Unit, Centre of Internal Medicine, Justus Liebig University, 35392 Giessen, Hesse, Germany. constanze.c.maresch@ernaehrung.uni-giessen.de.
[Ti] Título:Low Glycemic Index Prototype Isomaltulose-Update of Clinical Trials.
[So] Source:Nutrients;9(4), 2017 Apr 13.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Low glycemic index diets are supposed to achieve a more beneficial effect on blood glucose control in people with diabetes mellitus and may also provide metabolic benefits for the general population. A prototype of a low-glycemic index carbohydrate is the natural occurring disaccharide isomaltulose that can be commercially produced from sucrose (beet sugar) to industrial scale. It is currently used in various food and drink applications as well as special and clinical nutrition feeds and formula diet as a food ingredient and alternative sugar. Here we provide an overview on clinical trials with isomaltulose including an analysis of its effects on glycemia and fat oxidation as compared to high glycemic index sugars and carbohydrates. In addition, we discuss recent reports on beneficial effects in weight-loss maintenance and pregnancy.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 1/dietoterapia
Diabetes Mellitus Tipo 2/dietoterapia
Dieta para Diabéticos
Índice Glicêmico
Hiperglicemia/prevenção & controle
Isomaltose/análogos & derivados
Adoçantes Calóricos/uso terapêutico
[Mh] Termos MeSH secundário: Desempenho Atlético
Manutenção do Peso Corporal
Ensaios Clínicos como Assunto
Cognição
Diabetes Mellitus Tipo 1/sangue
Diabetes Mellitus Tipo 2/sangue
Dieta para Diabéticos/efeitos adversos
Dieta Redutora/efeitos adversos
Feminino
Seres Humanos
Isomaltose/efeitos adversos
Isomaltose/uso terapêutico
Masculino
Adoçantes Calóricos/efeitos adversos
Sobrepeso/prevenção & controle
Gravidez
Complicações na Gravidez/prevenção & controle
Fenômenos Fisiológicos da Nutrição Esportiva
Programas de Redução de Peso
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Nutritive Sweeteners); 67I334IX2M (Isomaltose); V59P50X4UY (isomaltulose)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE


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[PMID]:28355342
[Au] Autor:Chapuis-de-Andrade S; de Araujo RM; Lara DR
[Ad] Endereço:Faculdade de Biociências e de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
[Ti] Título:Association of weight control behaviors with body mass index and weight-based self-evaluation.
[So] Source:Rev Bras Psiquiatr;39(3):237-243, 2017 Jul-Sep.
[Is] ISSN:1809-452X
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Objective:: To determine the frequency of weight control behaviors (WCBs) and their correlation with body mass index (BMI) and weight-based self-evaluation. Methods:: Data were collected by the Brazilian Internet Study on Temperament and Psychopathology (BRAINSTEP) from 27,501 volunteers (30.4% men, mean age 28.9±8.7 years). Results:: The most prevalent WCBs for men and women were exhaustive physical exercise and prolonged fasting, respectively. Frequent exhaustive physical exercise was the only behavior more often adopted by men. BMI was positively associated with WCBs, which were very frequent in obese subjects. About 15% of normal-weight women reported using diuretics and laxatives, and 12.2% reported vomiting as a WCB at least occasionally. Among subjects who regarded body weight highly in their self-evaluation, there was a strong positive association with all WCBs, at similar degrees, in both genders. Compared to those who never base their intrinsic personal value on body weight, those who frequently base intrinsic value on body weight were at 25-30 times higher risk of inducing vomiting. Conclusion:: The prevalence of participants adopting WCBs was high, especially in women and obese subjects. Weight-based self-evaluation was more strongly associated with WCBs than BMI.
[Mh] Termos MeSH primário: Imagem Corporal/psicologia
Índice de Massa Corporal
Autoavaliação Diagnóstica
Transtornos da Alimentação e da Ingestão de Alimentos/epidemiologia
Comportamentos Relacionados com a Saúde
[Mh] Termos MeSH secundário: Adolescente
Adulto
Manutenção do Peso Corporal
Brasil/epidemiologia
Estudos Transversais
Exercício/psicologia
Jejum/psicologia
Transtornos da Alimentação e da Ingestão de Alimentos/psicologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Prevalência
Fatores Sexuais
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE


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[PMID]:28352287
[Au] Autor:Seguin RA; Folta SC; Nelson ME; Hanson KL; LaCroix AZ
[Ad] Endereço:College of Human Ecology, Division of Nutritional Sciences, Cornell University, 412 Savage Hall, Ithaca, NY 14853, USA.
[Ti] Título:Long-Term Body Weight Maintenance among StrongWomen-Healthy Hearts Program Participants.
[So] Source:J Environ Public Health;2017:4372048, 2017.
[Is] ISSN:1687-9813
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:. The repeated loss and regain of body weight, referred to as weight cycling, may be associated with negative health complications. Given today's obesity epidemic and related interventions to address obesity, it is increasingly important to understand contexts and factors associated with weight loss maintenance. This study examined BMI among individuals who had previously participated in a 12-week, evidence-based, nationally disseminated nutrition and physical activity program designed for overweight and obese middle-aged and older women. . Data were collected using follow-up surveys. Complete height and weight data were available for baseline, 12-week program completion (post-program) and follow-up (approximately 3 years later) for 154 women (response rate = 27.5%; BMI characteristics did not differ between responders and nonresponders). . Mean BMI decreased significantly from baseline to post-program (-0.5, < 0.001) and post-program to follow-up (-0.7, < 0.001). Seventy-five percent of survey respondents maintained or decreased BMI post-program to follow-up. Self-efficacy and social support for healthy eating behaviors (but not physical activity) were associated with BMI maintenance or additional weight loss. . These findings support the durability of weight loss following participation in a relatively short-term intervention.
[Mh] Termos MeSH primário: Manutenção do Peso Corporal
Exercício
Comportamento Alimentar
Promoção da Saúde/estatística & dados numéricos
Autoeficácia
Apoio Social
[Mh] Termos MeSH secundário: Adulto
Idoso
Índice de Massa Corporal
Feminino
Seres Humanos
Meia-Idade
Obesidade/prevenção & controle
Sobrepeso/prevenção & controle
Fatores de Tempo
Estados Unidos
Perda de Peso
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE
[do] DOI:10.1155/2017/4372048


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[PMID]:28298393
[Au] Autor:Roumans NJ; Vink RG; Fazelzadeh P; van Baak MA; Mariman EC
[Ad] Endereço:Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, Netherlands; and n.roumans@maastrichtuniversity.nl.
[Ti] Título:A role for leukocyte integrins and extracellular matrix remodeling of adipose tissue in the risk of weight regain after weight loss.
[So] Source:Am J Clin Nutr;105(5):1054-1062, 2017 May.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Weight loss (WL) is often followed by weight regain after an energy-restricted dietary intervention (DI). When people are following a diet, the volume of an adipocyte decreases by loss of triglycerides, which creates stress between the cell contents and the surrounding extracellular matrix (ECM). Previously, we observed that genetic variations in ECM genes are associated with an increased risk of weight regain. We investigated the relation between the expression of ECM genes during WL and a period of weight stabilization (WS) and the risk of weight regain. In this randomized controlled trial, 61 healthy overweight or obese participants followed either a 5-wk very-low-calorie diet (VLCD; 500 kcal/d) or a 12-wk low-calorie diet (1250 kcal/d) (WL period) with a subsequent 4-wk WS period and a 9-mo follow-up. The WL and WS periods combined were considered the DI. Abdominal subcutaneous adipose tissue biopsy samples were collected for microarray analysis. Gene expression changes for a broad set of ECM-related genes were correlated with the weight-regain percentage (WR%). A total of 26 of the 277 genes were significantly correlated with WR% during WL, WS, or the DI periods. Most correlations were observed in the VLCD group during the WS period. Four genes code for leukocyte-specific receptors. These and other genes belong to a group of 26 genes, among which the expression changes were highly correlated ( ≥ 0.7, ≤ 0.001). This group could be divided into 3 subclusters linking to 2 biological processes-leukocyte integrin gene activity and ECM remodeling-and a link to insulin sensitivity was also apparent. Our present findings indicate the importance of adipose tissue leukocytes for the risk of weight regain. ECM modification also seems to be involved, and we observed a link to insulin sensitivity. This trial was registered at clinicaltrials.gov as NCT01559415.
[Mh] Termos MeSH primário: Peso Corporal
Ingestão de Energia
Matriz Extracelular/metabolismo
Integrinas/metabolismo
Leucócitos/metabolismo
Obesidade/metabolismo
Gordura Subcutânea Abdominal
[Mh] Termos MeSH secundário: Adipócitos/metabolismo
Manutenção do Peso Corporal
Restrição Calórica
Dieta Redutora
Feminino
Expressão Gênica
Seres Humanos
Resistência à Insulina
Integrinas/genética
Masculino
Meia-Idade
Obesidade/dietoterapia
Obesidade/genética
Risco
Gordura Subcutânea Abdominal/citologia
Gordura Subcutânea Abdominal/metabolismo
Triglicerídeos/metabolismo
Ganho de Peso
Perda de Peso/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Integrins); 0 (Triglycerides)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.148874


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[PMID]:28294985
[Au] Autor:Sanchez M; Darimont C; Panahi S; Drapeau V; Marette A; Taylor VH; Doré J; Tremblay A
[Ad] Endereço:Faculty of Medicine, Department of Kinesiology, Laval University, Quebec, QC G1V 0A6, Canada. marina.sanchez@criucpq.ulaval.ca.
[Ti] Título:Effects of a Diet-Based Weight-Reducing Program with Probiotic Supplementation on Satiety Efficiency, Eating Behaviour Traits, and Psychosocial Behaviours in Obese Individuals.
[So] Source:Nutrients;9(3), 2017 Mar 15.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:This study evaluated the impact of probiotic supplementation (Lactobacillus rhamnosus CGMCC1.3724 (LPR)) on appetite sensations and eating behaviors in the context of a weight-reducing program. Obese men ( = 45) and women ( = 60) participated in a double-blind, randomized, placebo-controlled trial that included a 12-week weight loss period (Phase 1) based on moderate energy restriction, followed by 12 weeks of weight maintenance (Phase 2). During the two phases of the program, each subject consumed two capsules per day of either a placebo or a LPR formulation (10 mg of LPR equivalent to 1.6 108 CFU/capsule, 210 mg of oligofructose, and 90 mg of inulin). The LPR supplementation increased weight loss in women that was associated with a greater increase in the fasting desire to eat ( = 0.03). On the other hand, satiety efficiency (satiety quotient for desire to eat) at lunch increased ( = 0.02), whereas disinhibition ( = 0.05) and hunger ( = 0.02) scores decreased more in the LPR-treated women, when compared with the female control group. Additionally, the LPR female group displayed a more pronounced decrease in food craving ( = 0.05), and a decrease in the Beck Depression Inventory score ( = 0.05) that was significantly different from the change noted in the placebo group ( = 0.02), as well as a higher score in the Body Esteem Scale questionnaire ( = 0.06). In men, significant benefits of LPR on fasting fullness and cognitive restraint were also observed. Taken together, these observations lend support to the hypothesis that the gut-brain axis may impact appetite control and related behaviors in obesity management.
[Mh] Termos MeSH primário: Dieta Redutora/psicologia
Comportamentos Relacionados com a Saúde
Probióticos/administração & dosagem
Saciação/fisiologia
Perda de Peso
[Mh] Termos MeSH secundário: Adolescente
Adulto
Apetite
Manutenção do Peso Corporal
Método Duplo-Cego
Exercício
Feminino
Seres Humanos
Fome/fisiologia
Lactobacillus rhamnosus/metabolismo
Masculino
Meia-Idade
Obesidade/dietoterapia
Obesidade/psicologia
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE



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