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[PMID]:29176848
[Au] Autor:Mills MK; Ruder MG; Nayduch D; Michel K; Drolet BS
[Ad] Endereço:Division of Biology, Kansas State University, Manhattan, Kansas, United States of America.
[Ti] Título:Dynamics of epizootic hemorrhagic disease virus infection within the vector, Culicoides sonorensis (Diptera: Ceratopogonidae).
[So] Source:PLoS One;12(11):e0188865, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Culicoides sonorensis biting midges are confirmed vectors of epizootic hemorrhagic disease virus (EHDV), which causes mortality in white-tailed deer and ruminant populations. Currently, of the seven EHDV serotypes, only 1, 2, and 6 are detected in the USA, and very few studies have focused on the infection time course of these serotypes within the midge. The objective of this current research was to characterize EHDV-2 infection within the midge by measuring infection prevalence, virus dissemination, and viral load over the course of infection. Midges were fed a blood meal containing 106.9 PFU/ml EHDV-2, collected every 12 h from 0-2 days post feeding (dpf) and daily from 3-10 dpf, and cohorts of 20 C. sonorensis were processed using techniques that assessed EHDV infection and dissemination. Cytopathic effect assays and quantitative (q)PCR were used to determine infection prevalence, revealing a 50% infection rate by 10 dpf using both methods. Using immunohistochemistry, EHDV-2 infection was detectable at 5 dpf, and shown to disseminate from the midgut to other tissues, including fat body, eyes, and salivary glands by 5 dpf. Stain intensity increased from 5-8 dpf, indicating replication of EHDV-2 in secondary infection sites after dissemination. This finding is also supported by trends in viral load over time as determined by plaque assays and qPCR. An increase in titer between 4-5 dpf correlated with viral replication in the midgut as seen with staining at day 5, while the subsequent gradual increase in viral load from 8-10 dpf suggested viral replication in midges with disseminated infection. Overall, the data presented herein suggest that EHDV-2 disseminates via the hemolymph to secondary infection sites throughout the midge and demonstrate a high potential for transmission at five days at 25°C after an infective blood-meal.
[Mh] Termos MeSH primário: Ceratopogonidae/virologia
Vírus da Doença Hemorrágica Epizoótica/fisiologia
Insetos Vetores/virologia
Infecções por Reoviridae/epidemiologia
Infecções por Reoviridae/virologia
[Mh] Termos MeSH secundário: Animais
Chironomidae/virologia
Imuno-Histoquímica
Prevalência
Infecções por Reoviridae/patologia
Fatores de Tempo
Tropismo
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188865


  2 / 693 MEDLINE  
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[PMID]:28841413
[Au] Autor:Gutmann DH
[Ad] Endereço:Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: gutmannd@wustl.edu.
[Ti] Título:The Tropism of Pleiotrophin: Orchestrating Glioma Brain Invasion.
[So] Source:Cell;170(5):821-822, 2017 08 24.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The lateral ventricle (LV) is a preferential location for brain tumor spread; however, the instructive cues responsible for this unique tropism were previously unknown. In this issue, Qin et al. elucidate the underlying mechanism, demonstrating that LV-neural progenitors secrete a pleiotrophin (PTN)-containing complex, which attracts glioma cells through ROCK/Rho activation.
[Mh] Termos MeSH primário: Proteínas de Transporte
Glioma
[Mh] Termos MeSH secundário: Encéfalo
Neoplasias Encefálicas
Citocinas
Seres Humanos
Tropismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (Cytokines)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE


  3 / 693 MEDLINE  
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[PMID]:28754683
[Au] Autor:Ovchynnikova E; Aglialoro F; Bentlage AEH; Vidarsson G; Salinas ND; von Lindern M; Tolia NH; van den Akker E
[Ad] Endereço:Department Hematopoiesis, Sanquin Research, Amsterdam, The Netherlands.
[Ti] Título:DARC extracellular domain remodeling in maturating reticulocytes explains tropism.
[So] Source:Blood;130(12):1441-1444, 2017 Sep 21.
[Is] ISSN:1528-0020
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:is the most prevalent parasite species that causes malaria in humans and exclusively infects reticulocytes. Reticulocyte infection is facilitated by Duffy binding protein (DBP), which utilizes DARC (Duffy antigen receptor for chemokines) as an entry point. However, the selective tropism of for transferrin receptor (CD71)-positive reticulocytes remained unexplained, given the constitutive expression of DARC during reticulocyte maturation. CD71/RNA double staining of reticulocytes enriched from adult peripheral blood reveals 4 distinct reticulocyte populations: CD71 /RNA (∼0.016%), CD71 /RNA (∼0.059%), CD71 /RNA (∼0.37%), CD71 /RNA (∼0.55%), and erythrocytes CD71 /RNA (∼99%). We hypothesized that selective association of DBP with a small population of immature reticulocytes could explain the preference of for reticulocytes. Binding of specific monoclonal anti-DARC antibodies and recombinant DBP to CD71 /RNA reticulocytes was significantly higher compared with other reticulocyte populations and erythrocytes. Interestingly, the total DARC protein throughout reticulocyte maturation was constant. The data suggest that selective exposure of the DBP binding site within DARC is key to the preferential binding of DBP to immature reticulocytes, which is the potential mechanism underlying the preferential infection of a reticulocyte subset by .
[Mh] Termos MeSH primário: Sistema do Grupo Sanguíneo Duffy/química
Sistema do Grupo Sanguíneo Duffy/metabolismo
Espaço Extracelular/química
Plasmodium vivax/fisiologia
Receptores de Superfície Celular/química
Receptores de Superfície Celular/metabolismo
Reticulócitos/citologia
Reticulócitos/metabolismo
Tropismo/fisiologia
[Mh] Termos MeSH secundário: Especificidade de Anticorpos/imunologia
Antígenos de Protozoários/metabolismo
Diferenciação Celular
Eritrócitos/parasitologia
Seres Humanos
Domínios Proteicos
Proteínas de Protozoários/metabolismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Protozoan); 0 (DARC protein, human); 0 (Duffy Blood-Group System); 0 (Duffy antigen binding protein, Plasmodium); 0 (Protozoan Proteins); 0 (Receptors, Cell Surface)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171008
[Lr] Data última revisão:
171008
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170730
[St] Status:MEDLINE
[do] DOI:10.1182/blood-2017-03-774364


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[PMID]:28698207
[Au] Autor:Kosaisavee V; Suwanarusk R; Chua ACY; Kyle DE; Malleret B; Zhang R; Imwong M; Imerbsin R; Ubalee R; Sámano-Sánchez H; Yeung BKS; Ong JJY; Lombardini E; Nosten F; Tan KSW; Bifani P; Snounou G; Rénia L; Russell B
[Ad] Endereço:Department of Parasitology and Entomology, Faculty of Public Health, Mahidol University, Bangkok, Thailand.
[Ti] Título:Strict tropism for CD71 /CD234 human reticulocytes limits the zoonotic potential of .
[So] Source:Blood;130(11):1357-1363, 2017 Sep 14.
[Is] ISSN:1528-0020
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two malaria parasites of Southeast Asian macaques, and , can infect humans experimentally. In Malaysia, where both species are common, zoonotic knowlesi malaria has recently become dominant, and cases are recorded throughout the region. By contrast, to date, only a single case of naturally acquired has been found in humans. In this study, we show that whereas merozoites invade monkey red blood cells indiscriminately in vitro, in humans, they are restricted to reticulocytes expressing both transferrin receptor 1 (Trf1 or CD71) and the Duffy antigen/chemokine receptor (DARC or CD234). This likely contributes to the paucity of detectable zoonotic cynomolgi malaria. We further describe postinvasion morphologic and rheologic alterations in -infected human reticulocytes that are strikingly similar to those observed for These observations stress the value of as a model in the development of blood stage vaccines against vivax malaria.
[Mh] Termos MeSH primário: Antígenos CD/metabolismo
Sistema do Grupo Sanguíneo Duffy/metabolismo
Plasmodium cynomolgi/fisiologia
Receptores de Superfície Celular/metabolismo
Receptores da Transferrina/metabolismo
Reticulócitos/parasitologia
Tropismo
Zoonoses/parasitologia
[Mh] Termos MeSH secundário: Animais
Eritrócitos/parasitologia
Interações Hospedeiro-Parasita
Seres Humanos
Macaca
Merozoítos/fisiologia
Plasmodium vivax/fisiologia
Reologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD); 0 (CD71 antigen); 0 (DARC protein, human); 0 (Duffy Blood-Group System); 0 (Receptors, Cell Surface); 0 (Receptors, Transferrin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171008
[Lr] Data última revisão:
171008
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1182/blood-2017-02-764787


  5 / 693 MEDLINE  
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[PMID]:28481327
[Au] Autor:Dietrich D; Pang L; Kobayashi A; Fozard JA; Boudolf V; Bhosale R; Antoni R; Nguyen T; Hiratsuka S; Fujii N; Miyazawa Y; Bae TW; Wells DM; Owen MR; Band LR; Dyson RJ; Jensen OE; King JR; Tracy SR; Sturrock CJ; Mooney SJ; Roberts JA; Bhalerao RP; Dinneny JR; Rodriguez PL; Nagatani A; Hosokawa Y; Baskin TI; Pridmore TP; De Veylder L; Takahashi H; Bennett MJ
[Ad] Endereço:Centre for Plant Integrative Biology, University of Nottingham, Nottingham LE12 5RD, UK.
[Ti] Título:Root hydrotropism is controlled via a cortex-specific growth mechanism.
[So] Source:Nat Plants;3:17057, 2017 May 08.
[Is] ISSN:2055-0278
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Plants can acclimate by using tropisms to link the direction of growth to environmental conditions. Hydrotropism allows roots to forage for water, a process known to depend on abscisic acid (ABA) but whose molecular and cellular basis remains unclear. Here we show that hydrotropism still occurs in roots after laser ablation removed the meristem and root cap. Additionally, targeted expression studies reveal that hydrotropism depends on the ABA signalling kinase SnRK2.2 and the hydrotropism-specific MIZ1, both acting specifically in elongation zone cortical cells. Conversely, hydrotropism, but not gravitropism, is inhibited by preventing differential cell-length increases in the cortex, but not in other cell types. We conclude that root tropic responses to gravity and water are driven by distinct tissue-based mechanisms. In addition, unlike its role in root gravitropism, the elongation zone performs a dual function during a hydrotropic response, both sensing a water potential gradient and subsequently undergoing differential growth.
[Mh] Termos MeSH primário: Raízes de Plantas/crescimento & desenvolvimento
Tropismo
[Mh] Termos MeSH secundário: Ácido Abscísico/metabolismo
Arabidopsis/citologia
Arabidopsis/crescimento & desenvolvimento
Arabidopsis/metabolismo
Proteínas de Arabidopsis/metabolismo
Raízes de Plantas/citologia
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arabidopsis Proteins); 0 (mizu-kussei1 protein, Arabidopsis); 72S9A8J5GW (Abscisic Acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.1038/nplants.2017.57


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[PMID]:28437879
[Au] Autor:Capek S; Spinner RJ
[Ad] Endereço:Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
[Ti] Título:In Reply to "Perineural Spread or Neural Tropism? Discussion of a Paper and Description of an Unusual Case of Cervical Intradural Extramedullary Dumbbell Metastasis from Renal Cell Carcinoma".
[So] Source:World Neurosurg;100:699, 2017 04.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Carcinoma de Células Renais/secundário
Neoplasias da Medula Espinal
[Mh] Termos MeSH secundário: Carcinoma
Seres Humanos
Tropismo
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE


  7 / 693 MEDLINE  
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[PMID]:28437878
[Au] Autor:Rossini Z; Pessina F
[Ad] Endereço:Division of Neurosurgical Oncology, Humanitas Research Hospital, Rozzano, Milan, Italy; Division of Neurosurgery, Università degli Studi di Milano, Milan, Italy. Electronic address: zefferino.rossini@unimi.it.
[Ti] Título:Perineural Spread or Neural Tropism? Discussion of a Paper and Description of an Unusual Case of Cervical Intradural Extramedullary Dumbbell Metastasis from Renal Cell Carcinoma.
[So] Source:World Neurosurg;100:696-698, 2017 04.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Carcinoma de Células Renais/secundário
Neoplasias da Medula Espinal
[Mh] Termos MeSH secundário: Carcinoma
Seres Humanos
Tropismo
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE


  8 / 693 MEDLINE  
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[PMID]:28423319
[Au] Autor:Hastings AK; Yockey LJ; Jagger BW; Hwang J; Uraki R; Gaitsch HF; Parnell LA; Cao B; Mysorekar IU; Rothlin CV; Fikrig E; Diamond MS; Iwasaki A
[Ad] Endereço:Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
[Ti] Título:TAM Receptors Are Not Required for Zika Virus Infection in Mice.
[So] Source:Cell Rep;19(3):558-568, 2017 Apr 18.
[Is] ISSN:2211-1247
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tyro3, Axl, and Mertk (TAM) receptors are candidate entry receptors for infection with the Zika virus (ZIKV), an emerging flavivirus of global public health concern. To investigate the requirement of TAM receptors for ZIKV infection, we used several routes of viral inoculation and compared viral replication in wild-type versus Axl , Mertk , Axl Mertk , and Axl Tyro3 mice in various organs. Pregnant and non-pregnant mice treated with interferon-α-receptor (IFNAR)-blocking (MAR1-5A3) antibody and infected subcutaneously with ZIKV showed no reliance on TAMs for infection. In the absence of IFNAR-blocking antibody, adult female mice challenged intravaginally with ZIKV showed no difference in mucosal viral titers. Similarly, in young mice that were infected with ZIKV intracranially or intraperitoneally, ZIKV replication occurred in the absence of TAM receptors, and no differences in cell tropism were observed. These findings indicate that, in mice, TAM receptors are not required for ZIKV entry and infection.
[Mh] Termos MeSH primário: Proteínas Proto-Oncogênicas/metabolismo
Receptores Proteína Tirosina Quinases/metabolismo
Infecção pelo Zika virus/metabolismo
Zika virus/fisiologia
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Feminino
Feto/virologia
Injeções Intraperitoneais
Camundongos
Placenta/virologia
Gravidez
Tropismo
Vagina/virologia
Replicação Viral
c-Mer Tirosina Quinase
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proto-Oncogene Proteins); EC 2.7.10.1 (Mertk protein, mouse); EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases); EC 2.7.10.1 (Tyro3 protein, mouse); EC 2.7.10.1 (axl receptor tyrosine kinase); EC 2.7.10.1 (c-Mer Tyrosine Kinase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE


  9 / 693 MEDLINE  
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[PMID]:28420883
[Au] Autor:Spaan AN; van Strijp JAG; Torres VJ
[Ad] Endereço:Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands.
[Ti] Título:Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors.
[So] Source:Nat Rev Microbiol;15(7):435-447, 2017 Jul.
[Is] ISSN:1740-1534
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Staphylococcus aureus is a major bacterial pathogen that causes disease worldwide. The emergence of strains that are resistant to commonly used antibiotics and the failure of vaccine development have resulted in a renewed interest in the pathophysiology of this bacterium. Staphylococcal leukocidins are a family of bi-component pore-forming toxins that are important virulence factors. During the past five years, cellular receptors have been identified for all of the bi-component leukocidins. The identification of the leukocidin receptors explains the cellular tropism and species specificity that is exhibited by these toxins, which has important biological consequences. In this Review, we summarize the recent discoveries that have reignited interest in these toxins and provide an outlook for future research.
[Mh] Termos MeSH primário: Citotoxinas
Leucocidinas
Receptores de Superfície Celular
Staphylococcus aureus/patogenicidade
[Mh] Termos MeSH secundário: Seres Humanos
Leucocidinas/química
Leucocidinas/fisiologia
Receptores de Superfície Celular/metabolismo
Staphylococcus aureus/genética
Tropismo
Fatores de Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cytotoxins); 0 (Leukocidins); 0 (Receptors, Cell Surface); 0 (Virulence Factors)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1038/nrmicro.2017.27


  10 / 693 MEDLINE  
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[PMID]:28279769
[Au] Autor:Alonso F; Kirkpatrick CM; Jeong W; Fisahn C; Usman S; Rustagi T; Loukas M; Chapman JR; Oskouian RJ; Tubbs RS
[Ad] Endereço:Swedish Neuroscience Institute, Seattle, Washington, USA. Electronic address: fea4@case.edu.
[Ti] Título:Lumbar Facet Tropism: A Comprehensive Review.
[So] Source:World Neurosurg;102:91-96, 2017 Jun.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Scattered reports exist in the medical literature regarding facet tropism. However, this finding has had mixed conclusions regarding its origin and impact on the normal spine. METHODS: We performed a literature review of the anatomy, embryology, biomechanics, and pathology related to lumbar facet tropism. RESULTS: Facet tropism is most commonly found at L4-L5 vertebral segments and there is some evidence that this condition may lead to facet degenerative spondylolisthesis, intervertebral disc disease, and other degenerative conditions. CONCLUSION: Long-term analyses of patients are necessary to elucidate relationships between associated findings and facet tropism. In addition, a universally agreed definition that is more precise should be developed for future investigative studies.
[Mh] Termos MeSH primário: Vértebras Lombares/patologia
Região Lombossacral/patologia
Tropismo
Articulação Zigapofisária/anormalidades
Articulação Zigapofisária/patologia
[Mh] Termos MeSH secundário: Seres Humanos
Estudos Longitudinais
Vértebras Lombares/anormalidades
Vértebras Lombares/diagnóstico por imagem
Região Lombossacral/anormalidades
Região Lombossacral/diagnóstico por imagem
Imagem por Ressonância Magnética
Espondilolistese/diagnóstico por imagem
Espondilolistese/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE



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