Base de dados : MEDLINE
Pesquisa : G07.345.500 [Categoria DeCS]
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[PMID]:28463112
[Au] Autor:Edens BM; Yan J; Miller N; Deng HX; Siddique T; Ma YC
[Ad] Endereço:Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, United States.
[Ti] Título:A novel ALS-associated variant in regulates motor axon morphogenesis.
[So] Source:Elife;6, 2017 05 02.
[Is] ISSN:2050-084X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The etiological underpinnings of amyotrophic lateral sclerosis (ALS) are complex and incompletely understood, although contributions to pathogenesis by regulators of proteolytic pathways have become increasingly apparent. Here, we present a novel variant in that is associated with ALS and show that its expression compromises motor axon morphogenesis in mouse motor neurons and in zebrafish. We further demonstrate that the ALS-associated variant impairs proteasomal function, and identify the Wnt signaling pathway effector beta-catenin as a substrate. Inhibition of beta-catenin function rescues the variant-induced motor axon phenotypes. These findings provide a strong link between the regulation of axonal morphogenesis and a new ALS-associated gene variant mediated by protein degradation pathways.
[Mh] Termos MeSH primário: Esclerose Amiotrófica Lateral/genética
Esclerose Amiotrófica Lateral/patologia
Proteínas de Transporte/genética
Morfogênese
Neurônios Motores/citologia
Proteínas Nucleares/genética
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Camundongos
Complexo de Endopeptidases do Proteassoma/metabolismo
Proteólise
Peixe-Zebra
beta Catenina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (Nuclear Proteins); 0 (UBQLN4 protein, human); 0 (beta Catenin); EC 3.4.25.1 (Proteasome Endopeptidase Complex)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:29227993
[Au] Autor:McGurk PD; Swartz ME; Chen JW; Galloway JL; Eberhart JK
[Ad] Endereço:Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, United States of America.
[Ti] Título:In vivo zebrafish morphogenesis shows Cyp26b1 promotes tendon condensation and musculoskeletal patterning in the embryonic jaw.
[So] Source:PLoS Genet;13(12):e1007112, 2017 12.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Integrated development of diverse tissues gives rise to a functional, mobile vertebrate musculoskeletal system. However, the genetics and cellular interactions that drive the integration of muscle, tendon, and skeleton are poorly understood. In the vertebrate head, neural crest cells, from which cranial tendons derive, pattern developing muscles just as tendons have been shown to in limb and trunk tissue, yet the mechanisms of this patterning are unknown. From a forward genetic screen, we determined that cyp26b1 is critical for musculoskeletal integration in the ventral pharyngeal arches, particularly in the mandibulohyoid junction where first and second arch muscles interconnect. Using time-lapse confocal analyses, we detail musculoskeletal integration in wild-type and cyp26b1 mutant zebrafish. In wild-type fish, tenoblasts are present in apposition to elongating muscles and condense in discrete muscle attachment sites. In the absence of cyp26b1, tenoblasts are generated in normal numbers but fail to condense into nascent tendons within the ventral arches and, subsequently, muscles project into ectopic locales. These ectopic muscle fibers eventually associate with ectopic tendon marker expression. Genetic mosaic analysis demonstrates that neural crest cells require Cyp26b1 function for proper musculoskeletal development. Using an inhibitor, we find that Cyp26 function is required in a short time window that overlaps the dynamic window of tenoblast condensation. However, cyp26b1 expression is largely restricted to regions between tenoblast condensations during this time. Our results suggest that degradation of RA by this previously undescribed population of neural crest cells is critical to promote condensation of adjacent scxa-expressing tenoblasts and that these condensations are subsequently required for proper musculoskeletal integration.
[Mh] Termos MeSH primário: Desenvolvimento Embrionário/genética
Desenvolvimento Maxilofacial/genética
Morfogênese/genética
Ácido Retinoico 4 Hidroxilase/genética
[Mh] Termos MeSH secundário: Animais
Padronização Corporal/genética
Regulação da Expressão Gênica no Desenvolvimento
Arcada Osseodentária/embriologia
Desenvolvimento Muscular/genética
Músculo Esquelético/embriologia
Músculo Esquelético/metabolismo
Tendões/embriologia
Tendões/crescimento & desenvolvimento
Peixe-Zebra/embriologia
Peixe-Zebra/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
EC 1.14.14.1 (Retinoic Acid 4-Hydroxylase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1007112


  3 / 23322 MEDLINE  
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[PMID]:27771363
[Au] Autor:Decker RS
[Ad] Endereço:Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, PA 19104, United States. Electronic address: RDecker@gnf.org.
[Ti] Título:Articular cartilage and joint development from embryogenesis to adulthood.
[So] Source:Semin Cell Dev Biol;62:50-56, 2017 02.
[Is] ISSN:1096-3634
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Within each synovial joint, the articular cartilage is uniquely adapted to bear dynamic compressive loads and shear forces throughout the joint's range of motion. Injury and age-related degeneration of the articular cartilage often lead to significant pain and disability, as the intrinsic repair capability of the tissue is extremely limited. Current surgical and biological treatment options have been unable to restore cartilage de novo. Before successful clinical cartilage restoration strategies can be developed, a better understanding of how the cartilage forms during normal development is essential. This review focuses on recent progress made towards addressing key questions about articular cartilage morphogenesis, including the origin of synovial joint progenitor cells, postnatal development and growth of the tissue. These advances have provided novel insight into fundamental questions about the developmental biology of articular cartilage, as well as potential cell sources that may participate in joint response to injury.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Cartilagem Articular/embriologia
Desenvolvimento Embrionário
Articulações/embriologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Morfogênese
Células-Tronco/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  4 / 23322 MEDLINE  
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[PMID]:27771340
[Au] Autor:Ambrosini A; Gracia M; Proag A; Rayer M; Monier B; Suzanne M
[Ad] Endereço:LBCMCP UMR5088, Centre de Biologie Integrative (CBI), Université de Toulouse, CNRS, UPS, France.
[Ti] Título:Apoptotic forces in tissue morphogenesis.
[So] Source:Mech Dev;144(Pt A):33-42, 2017 04.
[Is] ISSN:1872-6356
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:It is now well established that apoptosis is induced in response to mechanical strain. Indeed, increasing compressive forces induces apoptosis in confined spheroids of tumour cells, whereas releasing stress reduces apoptosis in spheroids cultivated in free suspension (Cheng et al., 2009). Apoptosis can also be induced by applying a 100 to 250MPa pressure, as shown in different cultured cells (for review, see (Frey et al., 2008)). During epithelium development, the pressure caused by a fast-growing clone can trigger apoptosis at the vicinity of the clone, mediating mechanical cell competition (Levayer et al., 2016). While the effect of strain has long been known for its role in apoptosis induction, the reciprocal mechanism has only recently been highlighted. First demonstrated at the cellular level, the effect of an apoptotic cell on its direct neighbours has been analysed in different kinds of monolayer epithelium (Gu et al., 2011; Rosenblatt et al., 2001; Kuipers et al., 2014; Lubkov & Bar-Sagi, 2014). More recently, the concept of a broader impact of apoptotic cell behaviours on tissue mechanical strain has emerged from the characterisation of tissue remodelling during Drosophila development (Toyama et al., 2008; Monier et al., 2015). In the present review, we summarize our current knowledge on the mechanical impact of apoptosis during tissue remodelling.
[Mh] Termos MeSH primário: Apoptose/genética
Drosophila melanogaster/crescimento & desenvolvimento
Células Epiteliais/citologia
Regulação da Expressão Gênica no Desenvolvimento
Morfogênese/genética
[Mh] Termos MeSH secundário: Abdome/crescimento & desenvolvimento
Animais
Divisão Celular
Proteínas de Ligação a DNA/genética
Proteínas de Ligação a DNA/metabolismo
Proteínas de Drosophila/genética
Proteínas de Drosophila/metabolismo
Drosophila melanogaster/genética
Drosophila melanogaster/metabolismo
Células Epiteliais/metabolismo
Matriz Extracelular/metabolismo
Larva/genética
Larva/crescimento & desenvolvimento
Larva/metabolismo
Modelos Biológicos
Pupa/genética
Pupa/crescimento & desenvolvimento
Pupa/metabolismo
Estresse Mecânico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA-Binding Proteins); 0 (Drosophila Proteins); 0 (dwg protein, Drosophila); 0 (reaper protein, Drosophila)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  5 / 23322 MEDLINE  
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[PMID]:29240767
[Au] Autor:Phelep A; Laouari D; Bharti K; Burtin M; Tammaccaro S; Garbay S; Nguyen C; Vasseur F; Blanc T; Berissi S; Langa-Vives F; Fischer E; Druilhe A; Arnheiter H; Friedlander G; Pontoglio M; Terzi F
[Ad] Endereço:INSERM U1151-CNRS UMR 8253, Université Paris Descartes, Institut Necker Enfants Malades, Département « Croissance et Signalisation ¼, Hôpital Necker Enfants Malades, Paris, France.
[Ti] Título:MITF - A controls branching morphogenesis and nephron endowment.
[So] Source:PLoS Genet;13(12):e1007093, 2017 12.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Congenital nephron number varies widely in the human population and individuals with low nephron number are at risk of developing hypertension and chronic kidney disease. The development of the kidney occurs via an orchestrated morphogenetic process where metanephric mesenchyme and ureteric bud reciprocally interact to induce nephron formation. The genetic networks that modulate the extent of this process and set the final nephron number are mostly unknown. Here, we identified a specific isoform of MITF (MITF-A), a bHLH-Zip transcription factor, as a novel regulator of the final nephron number. We showed that overexpression of MITF-A leads to a substantial increase of nephron number and bigger kidneys, whereas Mitfa deficiency results in reduced nephron number. Furthermore, we demonstrated that MITF-A triggers ureteric bud branching, a phenotype that is associated with increased ureteric bud cell proliferation. Molecular studies associated with an in silico analyses revealed that amongst the putative MITF-A targets, Ret was significantly modulated by MITF-A. Consistent with the key role of this network in kidney morphogenesis, Ret heterozygosis prevented the increase of nephron number in mice overexpressing MITF-A. Collectively, these results uncover a novel transcriptional network that controls branching morphogenesis during kidney development and identifies one of the first modifier genes of nephron endowment.
[Mh] Termos MeSH primário: Rim/fisiologia
Fator de Transcrição Associado à Microftalmia/metabolismo
Néfrons/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Seres Humanos
Rim/embriologia
Rim/metabolismo
Masculino
Camundongos
Camundongos Transgênicos
Fator de Transcrição Associado à Microftalmia/genética
Morfogênese
Néfrons/anatomia & histologia
Néfrons/crescimento & desenvolvimento
Néfrons/metabolismo
Organogênese
Isoformas de Proteínas
Proteínas Proto-Oncogênicas c-ret/genética
Proteínas Proto-Oncogênicas c-ret/metabolismo
Ureter/metabolismo
Ureter/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Microphthalmia-Associated Transcription Factor); 0 (Protein Isoforms); EC 2.7.10.1 (Proto-Oncogene Proteins c-ret); EC 2.7.10.1 (RET protein, human); EC 2.7.10.1 (Ret protein, mouse)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1007093


  6 / 23322 MEDLINE  
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[PMID]:29254288
[Au] Autor:Dyszkiewicz-Konwinska M; Bryja A; Jopek K; Budna J; Khozmi R; Jeseta M; Bukowska D; Antosik P; Bruska M; Nowicki M; Zabel M; Kempisty B
[Ad] Endereço:Department of Biomaterials and Experimental Dentistry, Poznan University of Medical Sciences, Poznan, Poland.
[Ti] Título:Expression of genes responsible for cell morphogenesis involved in differentiation in porcine buccal pouch mucosal cells during long-term primary culture and real-time proliferation in vitro.
[So] Source:J Biol Regul Homeost Agents;31(4):855-864, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Recently, using experimental animal model, we demonstrated that porcine buccal pouch mucosal cells reflect increased proliferation capability during primary cultivation in vitro. Although the histological structure and morphogenesis in oral cavity is well recognized, the molecular mechanisms which regulate this process still need further investigation. This study was aimed to analyze the molecular marker expression profile involved in morphogenesis and differentiation capacity of porcine buccal pouch mucosal cells during their long-term primary cultivation in vitro. The experiment was performed on buccal pouch mucosal cells isolated from 80 pubertal crossbred Landrace gilts. After collection, the cells were treated enzymatically and transferred into a primary in vitro culture (IVC) system and cultured for 30 days. The cells were collected for RNA isolation after 7, 15 and 30 days of IVC and were checked for their real-time proliferative status using the RTCA system. We found an increased expression of FN1 and SOX9 genes when calculated against ACTB after 7, and 30 days of IVC, (P less than 0.01, P less than 0.001, respectively). The CXCL12 mRNA was down-regulated after 7, 15 and 30 days of IVC, but not statistically significant. Similar expression profile was observed when calculated against HPRT, however, DAB2 was found to be higher expressed at day 15 of IVC, (P less than 0.05). The cell index measured during real-time cell proliferation was substantially increased between 96 h and 147h of IVC and reached the log phase. Since FN1 and SOX9 revealed significant increase of expression after long-term culture in vitro, it is suggested that expression of these differentiation and stemness genes is accompanied by cell proliferation. Moreover, FN1 and SOX9 might be recognized as new markers of buccal pouch mucosal cell proliferation and differentiation in pigs in in vitro primary culture model.
[Mh] Termos MeSH primário: Células Epiteliais/metabolismo
Regulação da Expressão Gênica no Desenvolvimento
Lipocalina-2/genética
Morfogênese/genética
Mucosa Bucal/metabolismo
Fatores de Transcrição SOX9/genética
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular
Proliferação Celular
Quimiocina CXCL12/genética
Quimiocina CXCL12/metabolismo
Células Epiteliais/citologia
Feminino
Perfilação da Expressão Gênica
Hipoxantina Fosforribosiltransferase/genética
Hipoxantina Fosforribosiltransferase/metabolismo
Lipocalina-2/metabolismo
Mucosa Bucal/citologia
Mucosa Bucal/crescimento & desenvolvimento
Cultura Primária de Células
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Fatores de Transcrição SOX9/metabolismo
Transdução de Sinais
Suínos
Proteínas Supressoras de Tumor/genética
Proteínas Supressoras de Tumor/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chemokine CXCL12); 0 (Lipocalin-2); 0 (RNA, Messenger); 0 (SOX9 Transcription Factor); 0 (Tumor Suppressor Proteins); EC 2.4.2.8 (Hypoxanthine Phosphoribosyltransferase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


  7 / 23322 MEDLINE  
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[PMID]:28744861
[Au] Autor:Pan ZJ; Zhu CK; Wang H; Zhou FJ; Qiang XG
[Ad] Endereço:School of Life Science, Huaiyin Normal University, Huaian, 223300, China.
[Ti] Título:Gonadal morphogenesis and sex differentiation in cultured Ussuri catfish Tachysurus ussuriensis.
[So] Source:J Fish Biol;91(3):866-879, 2017 Sep.
[Is] ISSN:1095-8649
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to investigate the optimal developmental time to perform sex reversal in Ussuri catfish Tachysurus ussuriensis, to develop monosex breeding in aquaculture. Systematic observations of gonadal sex differentiation of P. ussiriensis were conducted. The genital ridge formed at 9 days post fertilization (dpf) and germ cells begin to proliferate at 17 dpf. The ovarian cavity began forming on 21 dpf and completed by 25 dpf while presumptive testis remained quiescent. The primary oocytes were at the chromatin nucleolus stage by 30 dpf, the peri-nucleolus stage by 44 dpf and the cortical alveoli stage by 64 dpf. The germinal vesicle migrated towards the animal pole (polarization) at 120 dpf. In presumptive testis, germ cells entered into mitosis and blood vessels appeared in the proximal gonad on 30 dpf. The efferent duct anlage appeared on 36 dpf and formation of seminal lobules with spermatogonia and lobules interstitium occurred at 120 dpf. Therefore, gonadal sex differentiation occurred earlier in females than in males, with the histological differentiation preceding cytologic differentiation in T. ussuriensis. This indicates that undifferentiated gonads directly differentiate into ovary or testis between 17 and 21 dpf and artificial induction of sexual reversal by oral steroid administration must be conducted before 17 dpf.
[Mh] Termos MeSH primário: Peixes-Gato/crescimento & desenvolvimento
Diferenciação Sexual/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Aquicultura/métodos
Proliferação Celular
Feminino
Células Germinativas/citologia
Células Germinativas/efeitos dos fármacos
Masculino
Morfogênese
Ovário/citologia
Ovário/efeitos dos fármacos
Ovário/crescimento & desenvolvimento
Testículo/citologia
Testículo/efeitos dos fármacos
Testículo/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1111/jfb.13388


  8 / 23322 MEDLINE  
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[PMID]:29298444
[Au] Autor:Niida Y; Inoue M; Ozaki M; Takase E
[Ad] Endereço:Division of Clinical Genetics, Multidisciplinary Medical Center, Kanazawa Medical University Hospital, Uchinada, Japan.
[Ti] Título:Human Malformation Syndromes of Defective GLI: Opposite Phenotypes of 2q14.2 (GLI2) and 7p14.2 (GLI3) Microdeletions and a GLIA/R Balance Model.
[So] Source:Cytogenet Genome Res;153(2):56-65, 2017.
[Is] ISSN:1424-859X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:GLI family zinc finger proteins are transcriptional effectors of the sonic hedgehog signaling pathway. GLI regulates gene expression and repression at various phases of embryonic morphogenesis. In humans, 4 GLI genes are known, and GLI2 (2q14.2) and GLI3 (7p14.1) mutations cause different syndromes. Here, we present 2 distinctive cases with a chromosomal microdeletion in one of these genes. Patient 1 is a 14-year-old girl with Culler-Jones syndrome. She manifested short stature, cleft palate, and mild intellectual/social disability caused by a 6.6-Mb deletion of 2q14.1q14.3. Patient 2 is a 2-year-old girl with Greig cephalopolysyndactyly contiguous gene deletion syndrome. She manifested macrocephaly, preaxial polysyndactyly, psychomotor developmental delay, cerebral cavernous malformations, and glucose intolerance due to a 6.2-Mb deletion of 7p14.1p12.3 which included GLI3, GCK, and CCM2. Each patient manifests a different phenotype which is associated with different functions of each GLI gene and different effects of the chromosomal contiguous gene deletion. We summarize the phenotypic extent of GLI2/3 syndromes in the literature and determine that these 2 syndromes manifest opposite features to a certain extent, such as midface hypoplasia or macrocephaly, and anterior or posterior side of polydactyly. We propose a GLIA/R balance model that may explain these findings.
[Mh] Termos MeSH primário: Anormalidades Múltiplas/genética
Acrocefalossindactilia/genética
Cromossomos Humanos Par 2/ultraestrutura
Cromossomos Humanos Par 7/ultraestrutura
Proteínas do Tecido Nervoso/deficiência
Proteínas Nucleares/deficiência
Proteína Gli2 com Dedos de Zinco/deficiência
Proteína Gli3 com Dedos de Zinco/deficiência
[Mh] Termos MeSH secundário: Adolescente
Pré-Escolar
Cromossomos Humanos Par 2/genética
Cromossomos Humanos Par 7/genética
Fissura Palatina/genética
Nanismo/genética
Feminino
Intolerância à Glucose/genética
Proteínas Hedgehog/fisiologia
Hemangioma Cavernoso do Sistema Nervoso Central/genética
Seres Humanos
Deficiência Intelectual/genética
Cariotipagem
Modelos Biológicos
Morfogênese/genética
Proteínas do Tecido Nervoso/genética
Proteínas do Tecido Nervoso/fisiologia
Proteínas Nucleares/genética
Proteínas Nucleares/fisiologia
Análise de Sequência com Séries de Oligonucleotídeos
Fenótipo
Deleção de Sequência
Transdução de Sinais/genética
Síndrome
Proteína Gli2 com Dedos de Zinco/genética
Proteína Gli2 com Dedos de Zinco/fisiologia
Proteína Gli3 com Dedos de Zinco/genética
Proteína Gli3 com Dedos de Zinco/fisiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (GLI2 protein, human); 0 (GLI3 protein, human); 0 (Hedgehog Proteins); 0 (Nerve Tissue Proteins); 0 (Nuclear Proteins); 0 (SHH protein, human); 0 (Zinc Finger Protein Gli2); 0 (Zinc Finger Protein Gli3)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.1159/000485227


  9 / 23322 MEDLINE  
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[PMID]:29320528
[Au] Autor:Peterson T; Müller GB
[Ad] Endereço:Department of Theoretical Biology, University of Vienna, Wien, Austria.
[Ti] Título:Developmental finite element analysis of cichlid pharyngeal jaws: Quantifying the generation of a key innovation.
[So] Source:PLoS One;13(1):e0189985, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Advances in imaging and modeling facilitate the calculation of biomechanical forces in biological specimens. These factors play a significant role during ontogenetic development of cichlid pharyngeal jaws, a key innovation responsible for one of the most prolific species diversifications in recent times. MicroCT imaging of radiopaque-stained vertebrate embryos were used to accurately capture the spatial relationships of the pharyngeal jaw apparatus in two cichlid species (Haplochromis elegans and Amatitlania nigrofasciata) for the purpose of creating a time series of developmental stages using finite element models, which can be used to assess the effects of biomechanical forces present in a system at multiple points of its ontogeny. Changes in muscle vector orientations, bite forces, force on the neurocranium where cartilage originates, and stress on upper pharyngeal jaws are analyzed in a comparative context. In addition, microCT scanning revealed the presence of previously unreported cement glands in A. nigrofasciata. The data obtained provide an underrepresented dimension of information on physical forces present in developmental processes and assist in interpreting the role of developmental dynamics in evolution.
[Mh] Termos MeSH primário: Estruturas Animais/anatomia & histologia
Ciclídeos/anatomia & histologia
Estresse Mecânico
[Mh] Termos MeSH secundário: Estruturas Animais/embriologia
Estruturas Animais/crescimento & desenvolvimento
Animais
Evolução Biológica
Região Branquial
Ciclídeos/embriologia
Ciclídeos/crescimento & desenvolvimento
Simulação por Computador
Ingestão de Alimentos/fisiologia
Análise de Elementos Finitos
Mastigação/fisiologia
Modelos Biológicos
Morfogênese
Contração Muscular
Músculos Faríngeos/embriologia
Músculos Faríngeos/crescimento & desenvolvimento
Músculos Faríngeos/fisiologia
Crânio/embriologia
Crânio/crescimento & desenvolvimento
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189985


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Texto completo
[PMID]:29225171
[Au] Autor:Bi C; Meng F; Yang L; Cheng L; Wang P; Chen M; Fang M; Xie H
[Ad] Endereço:Institute of Life Sciences, MOE Key Laboratory of Developmental Genes and Human Diseases, Southeast University, Nanjing 210096, China.
[Ti] Título:CtBP represses Dpp signaling as a dimer.
[So] Source:Biochem Biophys Res Commun;495(2):1980-1985, 2018 01 08.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:C-terminal binding protein (CtBP) is a highly conserved transcriptional co-repressor in animal development and human diseases. In Drosophila, CtBP is critical for fly development and is thought to exert its repressive roles in many signaling pathways including Dpp/BMP pathway. Here we provide evidence that although wild type CtBP negatively and dominantly influences Dpp signaling in fly presumptive wings, mutant CtBP unable to form dimer does not, indicating that dimerization is required for the repression role of CtBP in Dpp signaling in vivo.
[Mh] Termos MeSH primário: Oxirredutases do Álcool/metabolismo
Proteínas de Ligação a DNA/metabolismo
Proteínas de Drosophila/metabolismo
Drosophila/crescimento & desenvolvimento
Drosophila/metabolismo
Morfogênese/fisiologia
Asas de Animais/crescimento & desenvolvimento
Asas de Animais/metabolismo
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Regulação da Expressão Gênica no Desenvolvimento/fisiologia
Multimerização Proteica/fisiologia
Transdução de Sinais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA-Binding Proteins); 0 (Drosophila Proteins); 0 (dpp protein, Drosophila); EC 1.1.- (Alcohol Oxidoreductases); EC 1.1.1.- (C-terminal binding protein)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE



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