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  1 / 3658 MEDLINE  
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[PMID]:28985654
[Au] Autor:Tolussi CE; Gomes ADO; Kumar A; Ribeiro CS; Nostro FLL; Bain PA; de Souza GB; Cuña RD; Honji RM; Moreira RG
[Ad] Endereço:Laboratório de Metabolismo e Reprodução de Organismos Aquáticos, Departamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo. Rua do Matão, Trav.14, n° 321, 05508-090 São Paulo, SP, Brazil. Electronic address: ctolussi@usp.br.
[Ti] Título:Environmental pollution affects molecular and biochemical responses during gonadal maturation of Astyanax fasciatus (Teleostei: Characiformes: Characidae).
[So] Source:Ecotoxicol Environ Saf;147:926-934, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Endocrine disrupting compounds (EDCs) have the potential to alter fish reproduction at various levels of organization. The aim of this study was to assess the impact of a natural environment with heavily anthropogenic influence on the physiological processes involved in reproduction in the freshwater fish lambari (Astyanax fasciatus) using different biomarkers. Adult males and females were collected in different seasons from two distinct sites in the same watershed: Ponte Nova Reservoir (PN) considered a pristine or small anthropogenic influence reference point; and Billings Reservoir (Bil), subjected to a large anthropogenic impact. Biological indices, such as hepatosomatic index and gonadosomatic index (GSI), gonadal histomorphology, fecundity, and biomarkers such as plasma levels of estradiol (E2) as well as hepatic gene expression of its alfa nuclear receptor (ERα), were analyzed. Hepatic vitellogenin (VTG) gene expression was evaluated in both sexes, as an indicator of xenoestrogen exposure. Females collected at PN presented a typical annual variation reflected in GSI, whereas for those sampled at Bil the index did not change through the seasons. The higher concentration of E2 in males collected at Bil during spring/2013, together with the detection of VTG gene expression, suggest the presence of EDCs in the water. These EDCs may have also influenced fecundity of females from Bil, which was higher during winter and spring/2013. Gene expression of ERα and ovarian morphology did not differ between fish from both sites. Water conditions from Bil reservoir impacted by anthropic activity clearly interfered mainly with biomarkers of biological effect such as plasma E2 levels and absolute and relative fecundity, but also altered biomarkers of exposure as VTG gene expression. These facts support the notion that waterborne EDCs are capable of causing estrogenic activity in A. fasciatus.
[Mh] Termos MeSH primário: Characidae/metabolismo
Disruptores Endócrinos/toxicidade
Monitoramento Ambiental/métodos
Gônadas/efeitos dos fármacos
Organogênese/efeitos dos fármacos
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Biomarcadores/metabolismo
Brasil
Characidae/crescimento & desenvolvimento
Disruptores Endócrinos/análise
Estradiol/metabolismo
Feminino
Fertilidade/efeitos dos fármacos
Água Doce/química
Expressão Gênica/efeitos dos fármacos
Gônadas/crescimento & desenvolvimento
Gônadas/patologia
Masculino
Reprodução/efeitos dos fármacos
Estações do Ano
Vitelogeninas/metabolismo
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Endocrine Disruptors); 0 (Vitellogenins); 0 (Water Pollutants, Chemical); 4TI98Z838E (Estradiol)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171008
[St] Status:MEDLINE


  2 / 3658 MEDLINE  
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[PMID]:29382818
[Au] Autor:Sánchez-Iranzo H; Galardi-Castilla M; Minguillón C; Sanz-Morejón A; González-Rosa JM; Felker A; Ernst A; Guzmán-Martínez G; Mosimann C; Mercader N
[Ad] Endereço:Development of the Epicardium and Its Role during Regeneration Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII), Melchor Fernández Almagro 3, 28029, Madrid, Spain.
[Ti] Título:Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration.
[So] Source:Nat Commun;9(1):428, 2018 01 30.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:During development, mesodermal progenitors from the first heart field (FHF) form a primitive cardiac tube, to which progenitors from the second heart field (SHF) are added. The contribution of FHF and SHF progenitors to the adult zebrafish heart has not been studied to date. Here we find, using genetic tbx5a lineage tracing tools, that the ventricular myocardium in the adult zebrafish is mainly derived from tbx5a cells, with a small contribution from tbx5a SHF progenitors. Notably, ablation of ventricular tbx5a -derived cardiomyocytes in the embryo is compensated by expansion of SHF-derived cells. In the adult, tbx5a expression is restricted to the trabeculae and excluded from the outer cortical layer. tbx5a-lineage tracing revealed that trabecular cardiomyocytes can switch their fate and differentiate into cortical myocardium during adult heart regeneration. We conclude that a high degree of cardiomyocyte cell fate plasticity contributes to efficient regeneration.
[Mh] Termos MeSH primário: Ventrículos do Coração/citologia
Miocárdio/citologia
Miócitos Cardíacos/citologia
Regeneração/genética
Proteínas com Domínio T-Box/genética
Peixe-Zebra/genética
[Mh] Termos MeSH secundário: Animais
Animais Geneticamente Modificados
Diferenciação Celular
Linhagem da Célula/genética
Rastreamento de Células
Embrião não Mamífero
Regulação da Expressão Gênica no Desenvolvimento
Genes Reporter
Proteínas de Fluorescência Verde/genética
Proteínas de Fluorescência Verde/metabolismo
Ventrículos do Coração/crescimento & desenvolvimento
Ventrículos do Coração/metabolismo
Proteínas Luminescentes/genética
Proteínas Luminescentes/metabolismo
Miocárdio/metabolismo
Miócitos Cardíacos/metabolismo
Cadeias Leves de Miosina/genética
Cadeias Leves de Miosina/metabolismo
Organogênese/genética
Células-Tronco/citologia
Células-Tronco/metabolismo
Proteínas com Domínio T-Box/deficiência
Peixe-Zebra/crescimento & desenvolvimento
Peixe-Zebra/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Luminescent Proteins); 0 (Myosin Light Chains); 0 (T-Box Domain Proteins); 0 (T-box transcription factor 5); 0 (red fluorescent protein); 147336-22-9 (Green Fluorescent Proteins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02650-6


  3 / 3658 MEDLINE  
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[PMID]:29240767
[Au] Autor:Phelep A; Laouari D; Bharti K; Burtin M; Tammaccaro S; Garbay S; Nguyen C; Vasseur F; Blanc T; Berissi S; Langa-Vives F; Fischer E; Druilhe A; Arnheiter H; Friedlander G; Pontoglio M; Terzi F
[Ad] Endereço:INSERM U1151-CNRS UMR 8253, Université Paris Descartes, Institut Necker Enfants Malades, Département « Croissance et Signalisation ¼, Hôpital Necker Enfants Malades, Paris, France.
[Ti] Título:MITF - A controls branching morphogenesis and nephron endowment.
[So] Source:PLoS Genet;13(12):e1007093, 2017 12.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Congenital nephron number varies widely in the human population and individuals with low nephron number are at risk of developing hypertension and chronic kidney disease. The development of the kidney occurs via an orchestrated morphogenetic process where metanephric mesenchyme and ureteric bud reciprocally interact to induce nephron formation. The genetic networks that modulate the extent of this process and set the final nephron number are mostly unknown. Here, we identified a specific isoform of MITF (MITF-A), a bHLH-Zip transcription factor, as a novel regulator of the final nephron number. We showed that overexpression of MITF-A leads to a substantial increase of nephron number and bigger kidneys, whereas Mitfa deficiency results in reduced nephron number. Furthermore, we demonstrated that MITF-A triggers ureteric bud branching, a phenotype that is associated with increased ureteric bud cell proliferation. Molecular studies associated with an in silico analyses revealed that amongst the putative MITF-A targets, Ret was significantly modulated by MITF-A. Consistent with the key role of this network in kidney morphogenesis, Ret heterozygosis prevented the increase of nephron number in mice overexpressing MITF-A. Collectively, these results uncover a novel transcriptional network that controls branching morphogenesis during kidney development and identifies one of the first modifier genes of nephron endowment.
[Mh] Termos MeSH primário: Rim/fisiologia
Fator de Transcrição Associado à Microftalmia/metabolismo
Néfrons/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Seres Humanos
Rim/embriologia
Rim/metabolismo
Masculino
Camundongos
Camundongos Transgênicos
Fator de Transcrição Associado à Microftalmia/genética
Morfogênese
Néfrons/anatomia & histologia
Néfrons/crescimento & desenvolvimento
Néfrons/metabolismo
Organogênese
Isoformas de Proteínas
Proteínas Proto-Oncogênicas c-ret/genética
Proteínas Proto-Oncogênicas c-ret/metabolismo
Ureter/metabolismo
Ureter/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Microphthalmia-Associated Transcription Factor); 0 (Protein Isoforms); EC 2.7.10.1 (Proto-Oncogene Proteins c-ret); EC 2.7.10.1 (RET protein, human); EC 2.7.10.1 (Ret protein, mouse)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1007093


  4 / 3658 MEDLINE  
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[PMID]:29274337
[Au] Autor:Ueda K; Onishi A; Ito SI; Nakamura M; Takahashi M
[Ad] Endereço:Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology, Kobe, Hyogo, 650-0047, Japan; Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, 650-0017, Japan.
[Ti] Título:Generation of three-dimensional retinal organoids expressing rhodopsin and S- and M-cone opsins from mouse stem cells.
[So] Source:Biochem Biophys Res Commun;495(4):2595-2601, 2018 01 22.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Three-dimensional retinal organoids can be differentiated from embryonic stem cells/induced pluripotent stem cells (ES/iPS cells) under defined medium conditions. We modified the serum-free floating culture of embryoid body-like aggregates with quick reaggregation (SFEBq) culture procedure to obtain retinal organoids expressing more rod photoreceptors and S- and M-cone opsins. METHODS: Retinal organoids differentiated from mouse Nrl-eGFP iPS cells were cultured in various mediums during photoreceptor development. To promote rod photoreceptor development, organoids were maintained in media containing 9-cis retinoic acids (9cRA). To obtain retinal organoids with M-opsin expression, we cultured in medium with 1% fetal bovine serum (FBS) supplemented with T3, BMP4, and DAPT. Section immunohistochemistry was performed to visualize the expression of photoreceptor markers. RESULTS: In three-dimensional (3D) retinas exposed to 9cRA, rhodopsin was expressed earlier and S-cone opsins were suppressed. We could maintain 3D retinas up to DD 35 in culture media with 1% FBS. The 3D retinas expressed rhodopsin, S- and M-opsins, but most cone photoreceptors expressed either S- or M-opsins. CONCLUSION: By modifying culture conditions in the SFEBq protocol, we obtained rod-dominated 3D retinas and S- and M-opsin expressing 3D retinas.
[Mh] Termos MeSH primário: Órgãos Bioartificiais
Opsinas dos Cones/metabolismo
Retina/citologia
Retina/crescimento & desenvolvimento
Rodopsina/metabolismo
Células-Tronco/citologia
Engenharia Tecidual/métodos
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular/fisiologia
Células Cultivadas
Camundongos
Organogênese/fisiologia
Impressão Tridimensional
Células Fotorreceptoras Retinianas Cones/metabolismo
Células-Tronco/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cone Opsins); 9009-81-8 (Rhodopsin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE


  5 / 3658 MEDLINE  
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[PMID]:29257949
[Au] Autor:Hui SP; Sheng DZ; Sugimoto K; Gonzalez-Rajal A; Nakagawa S; Hesselson D; Kikuchi K
[Ad] Endereço:Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia.
[Ti] Título:Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs.
[So] Source:Dev Cell;43(6):659-672.e5, 2017 Dec 18.
[Is] ISSN:1878-1551
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The attenuation of ancestral pro-regenerative pathways may explain why humans do not efficiently regenerate damaged organs. Vertebrate lineages that exhibit robust regeneration, including the teleost zebrafish, provide insights into the maintenance of adult regenerative capacity. Using established models of spinal cord, heart, and retina regeneration, we discovered that zebrafish T -like (zT ) cells rapidly homed to damaged organs. Conditional ablation of zT cells blocked organ regeneration by impairing precursor cell proliferation. In addition to modulating inflammation, infiltrating zT cells stimulated regeneration through interleukin-10-independent secretion of organ-specific regenerative factors (Ntf3: spinal cord; Nrg1: heart; Igf1: retina). Recombinant regeneration factors rescued the regeneration defects associated with zT cell depletion, whereas Foxp3a-deficient zT cells infiltrated damaged organs but failed to express regenerative factors. Our data delineate organ-specific roles for T cells in maintaining pro-regenerative capacity that could potentially be harnessed for diverse regenerative therapies.
[Mh] Termos MeSH primário: Regeneração/fisiologia
Linfócitos T Reguladores/fisiologia
Peixe-Zebra/fisiologia
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular/fisiologia
Proliferação Celular/fisiologia
Fatores de Transcrição Forkhead/fisiologia
Coração/fisiologia
Modelos Animais
Regeneração Nervosa/fisiologia
Organogênese/imunologia
Organogênese/fisiologia
Retina/fisiologia
Medula Espinal/fisiologia
Proteínas de Peixe-Zebra/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Forkhead Transcription Factors); 0 (Foxp3 protein, zebrafish); 0 (Zebrafish Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180117
[Lr] Data última revisão:
180117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


  6 / 3658 MEDLINE  
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[PMID]:29183937
[Au] Autor:Irvine KD; Shraiman BI
[Ad] Endereço:Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway NJ 08854, USA Irvine@waksman.rutgers.edu Shraiman@kitp.ucsb.edu.
[Ti] Título:Mechanical control of growth: ideas, facts and challenges.
[So] Source:Development;144(23):4238-4248, 2017 Dec 01.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In his classic book , D'Arcy Thompson discussed the necessity of a physical and mathematical approach to understanding the relationship between growth and form. The past century has seen extraordinary advances in our understanding of biological components and processes contributing to organismal morphogenesis, but the mathematical and physical principles involved have not received comparable attention. The most obvious entry of physics into morphogenesis is via tissue mechanics. In this Review, we discuss the fundamental role of mechanical interactions between cells induced by growth in shaping a tissue. Non-uniform growth can lead to accumulation of mechanical stress, which in the context of two-dimensional sheets of tissue can specify the shape it assumes in three dimensions. A special class of growth patterns - conformal growth - does not lead to the accumulation of stress and can generate a rich variety of planar tissue shapes. Conversely, mechanical stress can provide a regulatory feedback signal into the growth control circuit. Both theory and experiment support a key role for mechanical interactions in shaping tissues and, via mechanical feedback, controlling epithelial growth.
[Mh] Termos MeSH primário: Crescimento/fisiologia
[Mh] Termos MeSH secundário: Animais
Fenômenos Biomecânicos
Proliferação Celular/fisiologia
Retroalimentação Fisiológica
Seres Humanos
Conceitos Matemáticos
Modelos Biológicos
Morfogênese/fisiologia
Organogênese/fisiologia
Transdução de Sinais
Estresse Mecânico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1242/dev.151902


  7 / 3658 MEDLINE  
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[PMID]:29183945
[Au] Autor:Ruiz-Herrero T; Alessandri K; Gurchenkov BV; Nassoy P; Mahadevan L
[Ad] Endereço:Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
[Ti] Título:Organ size control via hydraulically gated oscillations.
[So] Source:Development;144(23):4422-4427, 2017 Dec 01.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hollow vesicular tissues of various sizes and shapes arise in biological organs such as ears, guts, hearts, brains and even entire organisms. Regulating their size and shape is crucial for their function. Although chemical signaling has been thought to play a role in the regulation of cellular processes that feed into larger scales, it is increasingly recognized that mechanical forces are involved in the modulation of size and shape at larger length scales. Motivated by a variety of examples of tissue cyst formation and size control that show simultaneous growth and size oscillations, we create a minimal theoretical framework for the growth and dynamics of a soft, fluid-permeable, spherical shell. We show that these shells can relieve internal pressure by bursting intermittently, shrinking and re-growing, providing a simple mechanism by which hydraulically gated oscillations can regulate size. To test our theory, we develop an experimental set-up to monitor the growth and oscillations of a hollow tissue spheroid growing freely or when confined. A simple generalization of our theory to account for irreversible deformations allows us to explain the time scales and the amplitudes of oscillations in terms of the geometry and mechanical properties of the tissue shells. Taken together, our theory and experimental observations show how soft hydraulics can regulate the size of growing tissue shells.
[Mh] Termos MeSH primário: Modelos Biológicos
Tamanho do Órgão/fisiologia
[Mh] Termos MeSH secundário: Fenômenos Biomecânicos
Linhagem Celular
Seres Humanos
Hidrodinâmica
Microfluídica
Organogênese/fisiologia
Esferoides Celulares/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171204
[Lr] Data última revisão:
171204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1242/dev.153056


  8 / 3658 MEDLINE  
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[PMID]:29183943
[Au] Autor:Boselli F; Steed E; Freund JB; Vermot J
[Ad] Endereço:Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404 Illkirch, France.
[Ti] Título:Anisotropic shear stress patterns predict the orientation of convergent tissue movements in the embryonic heart.
[So] Source:Development;144(23):4322-4327, 2017 Dec 01.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Myocardial contractility and blood flow provide essential mechanical cues for the morphogenesis of the heart. In general, endothelial cells change their migratory behavior in response to shear stress patterns, according to flow directionality. Here, we assessed the impact of shear stress patterns and flow directionality on the behavior of endocardial cells, the specialized endothelial cells of the heart. At the early stages of zebrafish heart valve formation, we show that endocardial cells are converging to the valve-forming area and that this behavior depends upon mechanical forces. Quantitative live imaging and mathematical modeling allow us to correlate this tissue convergence with the underlying flow forces. We predict that tissue convergence is associated with the direction of the mean wall shear stress and of the gradient of harmonic phase-averaged shear stresses, which surprisingly do not match the overall direction of the flow. This contrasts with the usual role of flow directionality in vascular development and suggests that the full spatial and temporal complexity of the wall shear stress should be taken into account when studying endothelial cell responses to flow .
[Mh] Termos MeSH primário: Coração/embriologia
Modelos Cardiovasculares
Peixe-Zebra/embriologia
[Mh] Termos MeSH secundário: Animais
Anisotropia
Fenômenos Biomecânicos
Coxins Endocárdicos/citologia
Coxins Endocárdicos/embriologia
Células Endoteliais/citologia
Células Endoteliais/fisiologia
Eritrócitos/fisiologia
Hemodinâmica
Hidrodinâmica
Imagem Tridimensional
Organogênese/fisiologia
Resistência ao Cisalhamento
Estresse Mecânico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171204
[Lr] Data última revisão:
171204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1242/dev.152124


  9 / 3658 MEDLINE  
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[PMID]:28743799
[Au] Autor:Sheng L; Hu X; Du Y; Zhang G; Huang H; Scheres B; Xu L
[Ad] Endereço:National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China.
[Ti] Título:Non-canonical -mediated root branching contributes to plasticity in root system architecture.
[So] Source:Development;144(17):3126-3133, 2017 09 01.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lateral roots (LRs), which originate from the growing root, and adventitious roots (ARs), which are formed from non-root organs, are the main contributors to the post-embryonic root system in However, our knowledge of how formation of the root system is altered in response to diverse inductive cues is limited. Here, we show that contributes to root system plasticity. When seedlings are grown vertically on medium, is not expressed in LR founder cells. During AR initiation, is expressed in AR founder cells and activates also functions in LR formation and is activated in that context by / and not by This indicates that divergent initial processes that lead to ARs and LRs may converge on a similar mechanism for primordium development. Furthermore, we demonstrated that when plants are grown in soil or upon wounding on medium, the primary root is able to produce both -mediated and non- -mediated roots. The discovery of -mediated root-derived roots reveals a previously uncharacterized pathway that confers plasticity during the generation of root system architecture in response to different inductive cues.
[Mh] Termos MeSH primário: Proteínas de Arabidopsis/metabolismo
Arabidopsis/crescimento & desenvolvimento
Arabidopsis/metabolismo
Proteínas de Homeodomínio/metabolismo
Raízes de Plantas/crescimento & desenvolvimento
Raízes de Plantas/metabolismo
[Mh] Termos MeSH secundário: Proteínas de Arabidopsis/genética
Secas
Regulação da Expressão Gênica de Plantas
Proteínas de Homeodomínio/genética
Modelos Biológicos
Organogênese/genética
Solo
Regulação para Cima/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Arabidopsis Proteins); 0 (Homeodomain Proteins); 0 (LBD16 protein, Arabidopsis); 0 (Soil); 0 (WOX11 protein, Arabidopsis)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1242/dev.152132


  10 / 3658 MEDLINE  
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[PMID]:28455378
[Au] Autor:Chi L; Ahmed A; Roy AR; Vuong S; Cahill LS; Caporiccio L; Sled JG; Caniggia I; Wilson MD; Delgado-Olguin P
[Ad] Endereço:Translational Medicine, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.
[Ti] Título:G9a controls placental vascular maturation by activating the Notch Pathway.
[So] Source:Development;144(11):1976-1987, 2017 06 01.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Defective fetoplacental vascular maturation causes intrauterine growth restriction (IUGR). A transcriptional switch initiates placental maturation, during which blood vessels elongate. However, the cellular mechanisms and regulatory pathways involved are unknown. We show that the histone methyltransferase G9a, also known as Ehmt2, activates the Notch pathway to promote placental vascular maturation. Placental vasculature from embryos with G9a-deficient endothelial progenitor cells failed to expand owing to decreased endothelial cell proliferation and increased trophoblast proliferation. Moreover, G9a deficiency altered the transcriptional switch initiating placental maturation and caused downregulation of Notch pathway effectors including Importantly, Notch pathway activation in G9a-deficient endothelial progenitors extended embryonic life and rescued placental vascular expansion. Thus, G9a activates the Notch pathway to balance endothelial cell and trophoblast proliferation and coordinates the transcriptional switch controlling placental vascular maturation. Accordingly, and were downregulated in human placentae from IUGR-affected pregnancies, suggesting that G9a is an important regulator in placental diseases caused by defective vascular maturation.
[Mh] Termos MeSH primário: Antígenos de Histocompatibilidade/metabolismo
Histona-Lisina N-Metiltransferase/metabolismo
Placenta/irrigação sanguínea
Receptores Notch/metabolismo
Transdução de Sinais
[Mh] Termos MeSH secundário: Animais
Movimento Celular/genética
Proliferação Celular
Regulação para Baixo/genética
Embrião de Mamíferos/metabolismo
Embrião de Mamíferos/ultraestrutura
Desenvolvimento Embrionário/genética
Células Endoteliais/citologia
Células Endoteliais/metabolismo
Feminino
Retardo do Crescimento Fetal/genética
Regulação da Expressão Gênica no Desenvolvimento
Antígenos de Histocompatibilidade/genética
Histona-Lisina N-Metiltransferase/genética
Seres Humanos
Proteína de Ligação a Sequências Sinal de Recombinação J de Imunoglobina/genética
Proteína de Ligação a Sequências Sinal de Recombinação J de Imunoglobina/metabolismo
Camundongos
Organogênese/genética
Placenta/citologia
Placenta/ultraestrutura
Gravidez
Transdução de Sinais/genética
Células-Tronco/citologia
Células-Tronco/metabolismo
Transcrição Genética
Trofoblastos/citologia
Trofoblastos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Histocompatibility Antigens); 0 (Immunoglobulin J Recombination Signal Sequence-Binding Protein); 0 (RBPJ protein, human); 0 (Receptors, Notch); EC 2.1.1.43 (EHMT2 protein, human); EC 2.1.1.43 (G9a protein, mouse); EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1242/dev.148916



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