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Pesquisa : G07.345.500.325.377.750 [Categoria DeCS]
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  1 / 3259 MEDLINE  
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[PMID]:28469115
[Au] Autor:Babaji P; Devanna R; Jagtap K; Chaurasia VR; Jerry JJ; Choudhury BK; Duhan D
[Ad] Endereço:Department of Pedodontics, Sharavathi Dental College, Shimoga, Karnataka, India.
[Ti] Título:The cell biology and role of resorptive cells in diseases: A review.
[So] Source:Ann Afr Med;16(2):39-45, 2017 Apr-Jun.
[Is] ISSN:0975-5764
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Resorptive cells are responsible for the resorption of mineralized matrix of hard tissues. Bone-resorbing cells are called osteoclasts; however, they can resorb mineralized dental tissues or calcified cartilage and then they are called odontoclasts and chondroclasts, respectively. Resorptive cells form when mononuclear precursors derived from a monocyte-macrophage cell lineage are attracted to certain mineralized surfaces and subsequently fuse and adhere onto them for exerting their resorbing activity. These cells are responsible for degradation of calcified extracellular matrix composed of organic molecules and hydroxyapatite. The activity of these cells can be observed in both physiological and pathological processes throughout life and their activity is mainly required in bone turnover and growth, spontaneous and induced (orthodontic) tooth movement, tooth eruption, and bone fracture healing, as well as in pathological conditions such as osteoporosis, osteoarthritis, and bone metastasis. In addition, they are responsible for daily control of calcium homeostasis. Clastic cells also resorb the primary teeth for shedding before the permanent teeth erupt into the oral cavity.
[Mh] Termos MeSH primário: Calcificação Fisiológica/fisiologia
Odontogênese/fisiologia
Osteoclastos/fisiologia
[Mh] Termos MeSH secundário: Doenças Ósseas/patologia
Doenças Ósseas/fisiopatologia
Reabsorção Óssea
Seres Humanos
Dente Decíduo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.4103/aam.aam_97_16


  2 / 3259 MEDLINE  
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[PMID]:28872985
[Au] Autor:Al-Tuwirqi A; Seow WK
[Ti] Título:A Controlled Study of Pre-Eruptive Intracoronal Resorption and Dental Development.
[So] Source:J Clin Pediatr Dent;41(5):374-380, 2017.
[Is] ISSN:1053-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIM: To compare the prevalence of PEIR in Australian and Saudi Arabian children and to investigate the relationship of PEIR with dental development. STUDY DESIGN: Panoramic (PAN) radiographs of 842 Australian and 456 Saudi children were screened for PEIR. The dental ages of the children with and without PEIR were assessed from the PAN radiographs using the method of Demirjian and co-workers. RESULTS: The subject prevalence of PEIR was not statistically significant between Australian (2%) and Saudi children (0.6%) (p>0.1). The teeth most commonly affected by PEIR were the mandibular second molars and premolars. Dental impaction was observed in 31% of teeth with PEIR compared to only 0.1% of control teeth (p<0.0001). Children with PEIR showed a mean delay in dental development of 0.54±0.85 years compared with ageand gender-matched controls (p<0.0001). CONCLUSIONS: The present study provides the first evidence that there are no differences in PEIR prevalence between Australian and Saudi populations, and that dental development is significantly delayed in children with PEIR.
[Mh] Termos MeSH primário: Odontogênese
Radiografia Panorâmica
Reabsorção de Dente/diagnóstico por imagem
Dente não Erupcionado/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Austrália
Criança
Pré-Escolar
Feminino
Seres Humanos
Masculino
Arábia Saudita
Dente Impactado/diagnóstico por imagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.17796/1053-4628-41.5.374


  3 / 3259 MEDLINE  
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[PMID]:28832934
[Au] Autor:Smith TD; Muchlinski MN; Bucher WR; Vinyard CJ; Bonar CJ; Evans S; Williams LE; DeLeon VB
[Ad] Endereço:School of Physical Therapy, Slippery Rock University, Slippery Rock, Pennsylvania 16057.
[Ti] Título:Relative tooth size at birth in primates: Life history correlates.
[So] Source:Am J Phys Anthropol;164(3):623-634, 2017 Nov.
[Is] ISSN:1096-8644
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Dental eruption schedules have been closely linked to life history variables. Here we examine a sample of 50 perinatal primates (28 species) to determine whether life history traits correlate with relative tooth size at birth. MATERIALS AND METHODS: Newborn primates were studied using serial histological sectioning. Volumes of deciduous premolars (dp -dp ), replacement teeth (if any), and permanent molars (M ) of the upper jaw were measured and residuals from cranial length were calculated with least squares regressions to obtain relative dental volumes (RDVs). RESULTS: Relative dental volumes of deciduous or permanent teeth have an unclear relationship with relative neonatal mass in all primates. Relative palatal length (RPL), used as a proxy for midfacial size, is significantly, positively correlated with larger deciduous and permanent postcanine teeth. However, when strepsirrhines alone are examined, larger RPL is correlated with smaller RDV of permanent teeth. In the full sample, RDVs of deciduous premolars are significantly negatively correlated with relative gestation length (RGL), but have no clear relationship with relative weaning age. RDVs of molars lack a clear relationship with RGL; later weaning is associated with larger molar RDV, although correlations are not significant. When strepsirrhines alone are analyzed, clearer trends are present: longer gestations or later weaning are associated with smaller deciduous and larger permanent postcanine teeth (only gestational length correlations are significant). DISCUSSION: Our results indicate a broad trend that primates with the shortest RGLs precociously develop deciduous teeth; in strepsirrhines, the opposite trend is seen for permanent molars. Anthropoids delay growth of permanent teeth, while strepsirrhines with short RGLs are growing replacement teeth concurrently. A comparison of neonatal volumes with existing information on extent of cusp mineralization indicates that growth of tooth germs and cusp mineralization may be selected for independently.
[Mh] Termos MeSH primário: Animais Recém-Nascidos/fisiologia
Odontogênese/fisiologia
Primatas/fisiologia
Dente Decíduo/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Antropologia Física
Feminino
Maxila/anatomia & histologia
Dente Molar/anatomia & histologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1002/ajpa.23302


  4 / 3259 MEDLINE  
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[PMID]:28813629
[Au] Autor:Fons Romero JM; Star H; Lav R; Watkins S; Harrison M; Hovorakova M; Headon D; Tucker AS
[Ad] Endereço:1 Department of Craniofacial Development and Stem Cell Biology, King's College London, London, UK.
[Ti] Título:The Impact of the Eda Pathway on Tooth Root Development.
[So] Source:J Dent Res;96(11):1290-1297, 2017 Oct.
[Is] ISSN:1544-0591
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Eda pathway ( Eda, Edar, Edaradd) plays an important role in tooth development, determining tooth number, crown shape, and enamel formation. Here we show that the Eda pathway also plays a key role in root development. Edar (the receptor) is expressed in Hertwig's epithelial root sheath (HERS) during root development, with mutant mice showing a high incidence of taurodontism: large pulp chambers lacking or showing delayed bifurcation or trifurcation of the roots. The mouse upper second molars in the Eda pathway mutants show the highest incidence of taurodontism, this enhanced susceptibility being matched in human patients with mutations in EDA-A1. These taurodont teeth form due to defects in the direction of extension of the HERS from the crown, associated with a more extensive area of proliferation of the neighboring root mesenchyme. In those teeth where the angle at which the HERS extends from the crown is very wide and therefore more vertical, the mutant HERSs fail to reach toward the center of the tooth in the normal furcation region, and taurodont teeth are created. The phenotype is variable, however, with milder changes in angle and proliferation leading to normal or delayed furcation. This is the first analysis of the role of Eda in the root, showing a direct role for this pathway during postnatal mouse development, and it suggests that changes in proliferation and angle of HERS may underlie taurodontism in a range of syndromes.
[Mh] Termos MeSH primário: Cavidade Pulpar/anormalidades
Ectodisplasinas/genética
Dente Molar/anormalidades
Dente Molar/embriologia
Anormalidades Dentárias/genética
Raiz Dentária/anormalidades
Raiz Dentária/embriologia
[Mh] Termos MeSH secundário: Adolescente
Animais
Criança
Seres Humanos
Masculino
Camundongos
Odontogênese/genética
Fenótipo
Transdução de Sinais
Microtomografia por Raio-X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (EDA protein, human); 0 (Ectodysplasins); 0 (Eda protein, mouse)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE
[do] DOI:10.1177/0022034517725692


  5 / 3259 MEDLINE  
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[PMID]:28783411
[Au] Autor:Juuri E; Balic A
[Ad] Endereço:1 Department of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
[Ti] Título:The Biology Underlying Abnormalities of Tooth Number in Humans.
[So] Source:J Dent Res;96(11):1248-1256, 2017 Oct.
[Is] ISSN:1544-0591
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In past decades, morphologic, molecular, and cellular mechanisms that govern tooth development have been extensively studied. These studies demonstrated that the same signaling pathways regulate development of the primary and successional teeth. Mutations of these pathways lead to abnormalities in tooth development and number, including aberrant tooth shape, tooth agenesis, and formation of extra teeth. Here, we summarize the current knowledge on the development of the primary and successional teeth in animal models and describe some of the common tooth abnormalities in humans.
[Mh] Termos MeSH primário: Anormalidades Dentárias/embriologia
[Mh] Termos MeSH secundário: Animais
Anodontia/embriologia
Seres Humanos
Morfogênese
Odontogênese
Transdução de Sinais
Dente Supranumerário/embriologia
Fatores de Transcrição/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Transcription Factors)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE
[do] DOI:10.1177/0022034517720158


  6 / 3259 MEDLINE  
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[PMID]:28700256
[Au] Autor:Wang J; Martin JF
[Ad] Endereço:1 Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
[Ti] Título:Hippo Pathway: An Emerging Regulator of Craniofacial and Dental Development.
[So] Source:J Dent Res;96(11):1229-1237, 2017 Oct.
[Is] ISSN:1544-0591
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The evolutionarily conserved Hippo signaling pathway is a vital regulator of organ size that fine-tunes cell proliferation, apoptosis, and differentiation. A number of important studies have revealed critical roles of Hippo signaling and its effectors Yap (Yes-associated protein) and Taz (transcriptional coactivator with PDZ binding motif) in tissue development, homeostasis, and regeneration, as well as in tumorigenesis. In addition, recent studies have shown evidence of crosstalk between the Hippo pathway and other key signaling pathways, such as Wnt signaling, that not only regulates developmental processes but also contributes to disease pathogenesis. In this review, we summarize the major discoveries in the field of Hippo signaling and what has been learned about its regulation and crosstalk with other signaling pathways, with a particular focus on recent findings involving the Hippo-Yap pathway in craniofacial and tooth development. New and exciting studies of the Hippo pathway are anticipated that will significantly improve our understanding of the molecular mechanisms of human craniofacial and tooth development and disease and will ultimately lead to the development of new therapies.
[Mh] Termos MeSH primário: Desenvolvimento Maxilofacial/fisiologia
Morfogênese
Proteínas Nucleares/metabolismo
Proteínas Serina-Treonina Quinases/metabolismo
Transdução de Sinais
Fatores de Transcrição/metabolismo
[Mh] Termos MeSH secundário: Apoptose
Diferenciação Celular
Proliferação Celular
Seres Humanos
Odontogênese
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Nuclear Proteins); 0 (Transcription Factors); 0 (YY1AP1 protein, human); EC 2.7.11.1 (Hippo protein, human); EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1177/0022034517719886


  7 / 3259 MEDLINE  
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[PMID]:28665752
[Au] Autor:Wang J; Feng JQ
[Ad] Endereço:1 Biomedical Sciences, Texas A&M College of Dentistry, Dallas, TX, USA.
[Ti] Título:Signaling Pathways Critical for Tooth Root Formation.
[So] Source:J Dent Res;96(11):1221-1228, 2017 Oct.
[Is] ISSN:1544-0591
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tooth is made of an enamel-covered crown and a cementum-covered root. Studies on crown dentin formation have been a major focus in tooth development for several decades. Interestingly, the population prevalence for genetic short root anomaly (SRA) with no apparent defects in crown is close to 1.3%. Furthermore, people with SRA itself are predisposed to root resorption during orthodontic treatment. The discovery of the unique role of Nfic (nuclear factor I C; a transcriptional factor) in controlling root but not crown dentin formation points to a new concept: tooth crown and root have different control mechanisms. Further genetic mechanism studies have identified more key molecules (including Osterix, ß-catenin, and sonic hedgehog) that play a critical role in root formation. Extensive studies have also revealed the critical role of Hertwig's epithelial root sheath in tooth root formation. In addition, Wnt10a has recently been found to be linked to multirooted tooth furcation formation. These exciting findings not only fill the critical gaps in our understanding about tooth root formation but will aid future research regarding the identifying factors controlling tooth root size and the generation of a whole "bio-tooth" for therapeutic purposes. This review starts with human SRA and mainly focuses on recent progress on the roles of NFIC-dependent and NFIC-independent signaling pathways in tooth root formation. Finally, this review includes a list of the various Cre transgenic mouse lines used to achieve tooth root formation-related gene deletion or overexpression, as well as strengths and limitations of each line.
[Mh] Termos MeSH primário: Odontogênese/fisiologia
Transdução de Sinais
Raiz Dentária/embriologia
[Mh] Termos MeSH secundário: Animais
Cemento Dentário/embriologia
Dentina/embriologia
Órgão do Esmalte/embriologia
Proteínas Hedgehog/metabolismo
Seres Humanos
Camundongos
Fatores de Transcrição NFI/metabolismo
Proteínas do Tecido Nervoso/metabolismo
Odontogênese/genética
Fator de Transcrição Sp7
Fatores de Transcrição/metabolismo
Proteínas Wnt/metabolismo
beta Catenina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Hedgehog Proteins); 0 (NFI Transcription Factors); 0 (Nerve Tissue Proteins); 0 (Sp7 Transcription Factor); 0 (Sp7 protein, human); 0 (Sp7 protein, mouse); 0 (Transcription Factors); 0 (WNT10A protein, human); 0 (Wnt Proteins); 0 (Wnt10a protein, mouse); 0 (beta Catenin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1177/0022034517717478


  8 / 3259 MEDLINE  
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[PMID]:28605602
[Au] Autor:Hampl M; Cela P; Szabo-Rogers HL; Bosakova MK; Dosedelova H; Krejci P; Buchtova M
[Ad] Endereço:1 Institute of Animal Physiology and Genetics, v.v.i., Czech Academy of Sciences, Brno, Czech Republic.
[Ti] Título:Role of Primary Cilia in Odontogenesis.
[So] Source:J Dent Res;96(9):965-974, 2017 Aug.
[Is] ISSN:1544-0591
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Primary cilium is a solitary organelle that emanates from the surface of most postmitotic mammalian cells and serves as a sensory organelle, transmitting the mechanical and chemical cues to the cell. Primary cilia are key coordinators of various signaling pathways during development and maintenance of tissue homeostasis. The emerging evidence implicates primary cilia function in tooth development. Primary cilia are located in the dental epithelium and mesenchyme at early stages of tooth development and later during cell differentiation and production of hard tissues. The cilia are present when interactions between both the epithelium and mesenchyme are required for normal morphogenesis. As the primary cilium coordinates several signaling pathways essential for odontogenesis, ciliary defects can interrupt the latter process. Genetic or experimental alterations of cilia function lead to various developmental defects, including supernumerary or missing teeth, enamel and dentin hypoplasia, or teeth crowding. Moreover, dental phenotypes are observed in ciliopathies, including Bardet-Biedl syndrome, Ellis-van Creveld syndrome, Weyers acrofacial dysostosis, cranioectodermal dysplasia, and oral-facial-digital syndrome, altogether demonstrating that primary cilia play a critical role in regulation of both the early odontogenesis and later differentiation of hard tissue-producing cells. Here, we summarize the current evidence for the localization of primary cilia in dental tissues and the impact of disrupted cilia signaling on tooth development in ciliopathies.
[Mh] Termos MeSH primário: Cílios/fisiologia
Odontogênese/fisiologia
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular/fisiologia
Seres Humanos
Desenvolvimento Maxilofacial/fisiologia
Transdução de Sinais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.1177/0022034517713688


  9 / 3259 MEDLINE  
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[PMID]:28605600
[Au] Autor:Kwon HE; Jia S; Lan Y; Liu H; Jiang R
[Ad] Endereço:1 Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
[Ti] Título:Activin and Bmp4 Signaling Converge on Wnt Activation during Odontogenesis.
[So] Source:J Dent Res;96(10):1145-1152, 2017 Sep.
[Is] ISSN:1544-0591
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previous studies show that both activin and Bmp4 act as crucial mesenchymal odontogenic signals during early tooth development. Remarkably, mice lacking activin-ßA ( Inhba ) and mice with neural crest-specific inactivation of Bmp4 ( Bmp4 ) both exhibit bud-stage developmental arrest of the mandibular molar tooth germs while their maxillary molar tooth germs completed morphogenesis. In this study, we found that, whereas expression of Inhba and Bmp4 in the developing tooth mesenchyme is independent of each other, Bmp4 Inhba compound mutant mice exhibit early developmental arrest of all tooth germs. Moreover, genetic inactivation of Osr2, a negative regulator of the odontogenic function of the Bmp4-Msx1 signaling pathway, rescues mandibular molar morphogenesis in Inhba embryos. We recently reported that Osr2 and the Bmp4-Msx1 pathway control the bud-to-cap transition of tooth morphogenesis through antagonistic regulation of expression of secreted Wnt antagonists, including Dkk2 and Sfrp2, in the developing tooth mesenchyme. We show here that expression of Dkk2 messenger RNAs was significantly upregulated and expanded into the tooth bud mesenchyme in Inhba embryos in comparison with wild-type littermates. Furthermore, in utero treatment with either lithium chloride, an agonist of canonical Wnt signaling, or the DKK inhibitor IIIC3a rescued mandibular molar tooth morphogenesis in Inhba embryos. Together with our finding that the developing mandibular molar tooth bud mesenchyme expresses significantly higher levels of Dkk2 than the developing maxillary molar tooth mesenchyme, these data indicate that Bmp4 and activin signaling pathways converge on activation of the Wnt signaling pathway to promote tooth morphogenesis through the bud-to-cap transition and that the differential effects of loss of activin or Bmp4 signaling on maxillary and mandibular molar tooth morphogenesis are mainly due to the differential expression of Wnt antagonists, particularly Dkk2, in the maxillary and mandibular tooth mesenchyme.
[Mh] Termos MeSH primário: Ativinas/fisiologia
Proteína Morfogenética Óssea 4/fisiologia
Dente Molar/embriologia
Odontogênese/fisiologia
Germe de Dente/embriologia
Via de Sinalização Wnt/fisiologia
[Mh] Termos MeSH secundário: Animais
Regulação da Expressão Gênica no Desenvolvimento
Hibridização In Situ
Peptídeos e Proteínas de Sinalização Intercelular/metabolismo
Microdissecção e Captura a Laser
Cloreto de Lítio/farmacologia
Proteínas de Membrana/metabolismo
Camundongos
Camundongos Transgênicos
RNA Mensageiro/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Transdução de Sinais
Fatores de Transcrição/metabolismo
Fatores de Transcrição/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Morphogenetic Protein 4); 0 (Dkk2 protein, mouse); 0 (Intercellular Signaling Peptides and Proteins); 0 (Membrane Proteins); 0 (Osr2 protein, mouse); 0 (RNA, Messenger); 0 (Sfrp2 protein, mouse); 0 (Transcription Factors); 104625-48-1 (Activins); G4962QA067 (Lithium Chloride)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.1177/0022034517713710


  10 / 3259 MEDLINE  
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[PMID]:28576771
[Au] Autor:Feng J; Jing J; Li J; Zhao H; Punj V; Zhang T; Xu J; Chai Y
[Ad] Endereço:Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.
[Ti] Título:BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice.
[So] Source:Development;144(14):2560-2569, 2017 07 15.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Signaling pathways are used reiteratively in different developmental processes yet produce distinct cell fates through specific downstream transcription factors. In this study, we used tooth root development as a model with which to investigate how the BMP signaling pathway regulates transcriptional complexes to direct the fate determination of multipotent mesenchymal stem cells (MSCs). We first identified the MSC population supporting mouse molar root growth as Gli1 cells. Using a Gli1-driven Cre-mediated recombination system, our results provide the first evidence that BMP signaling activity is required for the odontogenic differentiation of MSCs. Specifically, we identified the transcription factors Pax9, Klf4, Satb2 and Lhx8 as being downstream of BMP signaling and expressed in a spatially restricted pattern that is potentially involved in determining distinct cellular identities within the dental mesenchyme. Finally, we found that overactivation of one key transcription factor, Klf4, which is associated with the odontogenic region, promotes odontogenic differentiation of MSCs. Collectively, our results demonstrate the functional significance of BMP signaling in regulating MSC fate during root development and shed light on how BMP signaling can achieve functional specificity in regulating diverse organ development.
[Mh] Termos MeSH primário: Proteínas Morfogenéticas Ósseas/metabolismo
Células Mesenquimais Estromais/citologia
Células Mesenquimais Estromais/metabolismo
[Mh] Termos MeSH secundário: Animais
Proteínas Morfogenéticas Ósseas/genética
Diferenciação Celular/genética
Diferenciação Celular/fisiologia
Linhagem da Célula/genética
Linhagem da Célula/fisiologia
Feminino
Redes Reguladoras de Genes
Masculino
Camundongos
Camundongos Transgênicos
Odontoblastos/citologia
Odontoblastos/metabolismo
Odontogênese/genética
Odontogênese/fisiologia
Regeneração/genética
Regeneração/fisiologia
Transdução de Sinais/genética
Transdução de Sinais/fisiologia
Nicho de Células-Tronco/genética
Nicho de Células-Tronco/fisiologia
Raiz Dentária/citologia
Raiz Dentária/crescimento & desenvolvimento
Raiz Dentária/metabolismo
Fatores de Transcrição/genética
Fatores de Transcrição/metabolismo
Proteína GLI1 em Dedos de Zinco/genética
Proteína GLI1 em Dedos de Zinco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Bone Morphogenetic Proteins); 0 (Gli protein, mouse); 0 (Transcription Factors); 0 (Zinc Finger Protein GLI1)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170604
[St] Status:MEDLINE
[do] DOI:10.1242/dev.150136



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