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[PMID]:27778640
[Au] Autor:Legro RS; Kunselman AR; Stetter CM; Gnatuk CL; Estes SJ; Brindle E; Vesper HW; Botelho JC; Lee PA; Dodson WC
[Ad] Endereço:Departments of Obstetrics and Gynecology.
[Ti] Título:Normal Pubertal Development in Daughters of Women With PCOS: A Controlled Study.
[So] Source:J Clin Endocrinol Metab;102(1):122-131, 2017 Jan 01.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Context: Daughters of women with polycystic ovary syndrome (PCOS) are thought to be at increased risk for developing stigmata of the syndrome, but the ontogeny during puberty is uncertain. Objective: We phenotyped daughters (n = 76) of mothers with PCOS and daughters (n = 80) from control mothers for reproductive and metabolic parameters characteristic of PCOS. Design, Setting, and Participants: We performed a matched case/control study at Penn State Hershey Medical Center that included non-Hispanic, white girls 4 to 17 years old. Intervention: We obtained birth history, biometric, ovarian ultrasounds, whole-body dual-energy X-ray absorptiometry scan for body composition, 2-hour glucose challenged salivary insulin levels, and two timed urinary collections (12 hours overnight and 3 hours in the morning) for gonadotropins and sex steroids. Main Outcome Measures: We measured integrated urinary levels of adrenal (dehydroepiandrosterone sulfate) and ovarian [testosterone (TT)] steroids. Other endpoints included integrated salivary insulin levels and urinary luteinizing hormone levels. Results: There were no differences in detection rates or mean levels for gonadotropins and sex steroids in timed urinary collections between PCOS daughters and control daughters, nor were there differences in integrated salivary insulin levels. Results showed that 69% of Tanner 4/5 PCOS daughters vs 31% of control daughters had hirsutism defined as a Ferriman-Gallwey score >8 (P = 0.04). There were no differences in body composition as determined by dual-energy X-ray absorptiometry between groups in the three major body contents (i.e., bone, lean body mass, and fat) or in ovarian volume between groups. Conclusions: Matched for pubertal stage, PCOS daughters have similar levels of urinary androgens and gonadotropins as well as glucose-challenged salivary insulin levels.
[Mh] Termos MeSH primário: Filho de Pais Incapacitados/estatística & dados numéricos
Insulina/metabolismo
Síndrome do Ovário Policístico/fisiopatologia
Puberdade/metabolismo
Maturidade Sexual/fisiologia
[Mh] Termos MeSH secundário: Biomarcadores/análise
Composição Corporal
Estudos de Casos e Controles
Criança
Feminino
Seguimentos
Teste de Tolerância a Glucose
Seres Humanos
Masculino
Núcleo Familiar
Prognóstico
Testosterona/sangue
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Insulin); 3XMK78S47O (Testosterone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2016-2707


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[PMID]:28985536
[Au] Autor:Li L; Li X; Chen X; Chen Y; Liu J; Chen F; Ge F; Ye L; Lian Q; Ge RS
[Ad] Endereço:Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou, Zhejiang 325027, China.
[Ti] Título:Perfluorooctane sulfonate impairs rat Leydig cell development during puberty.
[So] Source:Chemosphere;190:43-53, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Perfluorooctane sulfonate (PFOS) possibly delays male sexual development. However, its effects on pubertal Leydig cell development are unclear. The objective of the present study was to investigate the effects of in vivo PFOS exposure on rat Leydig cell development during puberty. Immature male Sprague Dawley rats were gavaged 5 or 10 mg/kg PFOS on postnatal day 35 for 21 days. Compared to the control (0 mg/kg), PFOS lowered serum testosterone levels without altering luteinizing hormone and follicle-stimulating hormone levels on postnatal day 56. PFOS in vivo downregulated mRNA or protein levels of Leydig cells (Lhcgr, Cyp11a1, and Cyp17a1). PFOS in vitro inhibited androgen secretion in immature Leydig cells at ≥ 50 nM, most possibly via downregulating Hsd17b3 mRNA level. At ≥ 500 nM, PFOS downregulated Lhcgr, inhibited BCL-2 and increased BAX levels to cause Leydig cell apoptosis. In conclusion, PFOS at a lower dose directly inhibited pubertal development of Leydig cells.
[Mh] Termos MeSH primário: Ácidos Alcanossulfônicos/toxicidade
Fluorcarbonetos/toxicidade
Células Intersticiais do Testículo/efeitos dos fármacos
Maturidade Sexual/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Regulação para Baixo
Células Intersticiais do Testículo/patologia
Hormônio Luteinizante/efeitos dos fármacos
Hormônio Luteinizante/metabolismo
Masculino
Proteínas/efeitos dos fármacos
Proteínas/metabolismo
RNA Mensageiro/metabolismo
Ratos
Ratos Sprague-Dawley
Testosterona/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanesulfonic Acids); 0 (Fluorocarbons); 0 (Proteins); 0 (RNA, Messenger); 3XMK78S47O (Testosterone); 9002-67-9 (Luteinizing Hormone); 9H2MAI21CL (perfluorooctane sulfonic acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


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[PMID]:29425002
[Au] Autor:Shaykhelislamova MV; Dikopol'skaya NB; Bilalova GA; Zefirov TL
[Ti] Título:[State of adaptive systems of the body in boys aged of 11-15 years in the process of their age development, pubertal maturation and in the dynamics of the school year].
[So] Source:Gig Sanit;95(7):661-5, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:A comprehensive study of the functional state of the sympathoadrenal system (SAS) and adrenal cortex (AC) in boys aged of 11-15 years, was carried out depending on their age, puberty stage and academic year period, on the basis of indices of the daily adrenaline (A), noradrenaline (NA), 17-ketosteroids (17-KS) and 17-oxyketosteroids (17-OKS) excretion. A certain synchronism of the manifestation offunctional activity of the SAS mediator level, glucocorticoid and androgen AC function is determined as boys grow older and during their pubertal changes. At the same time the different dynamics of the studied indices in boys aged of from 14 to 15 years and by the V puberty stage is marked. During the academic year changes of hormone and hormonal metabolite excretion, having a different focus and intensity in the age groups were observed: a significant decrease of age NA excretion and androgen metabolite indices (at 15) of 14 and 15 year-old teenagers at the end of the academic year is found out, against the backdrop of a substantial and long-term increase of glucocorticoids (February, April), with their dangerous catabolic effect on a child's body and their depressing effect on the immune response.
[Mh] Termos MeSH primário: Adaptação Fisiológica/fisiologia
Desenvolvimento do Adolescente/fisiologia
Desenvolvimento Infantil/fisiologia
Hormônios
Puberdade/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Hormônios/análise
Hormônios/sangue
Seres Humanos
Masculino
Federação Russa/epidemiologia
Serviços de Saúde Escolar/estatística & dados numéricos
Maturidade Sexual/fisiologia
Estatística como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hormones)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE


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[PMID]:27770258
[Au] Autor:Franke D; Steffens R; Thomas L; Pavicic L; Ahlenstiel T; Pape L; Gellermann J; Müller D; Querfeld U; Haffner D; Zivicnjak M
[Ad] Endereço:Department of Pediatric Kidney, Liver and Metabolic Diseases, Children's Hospital, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany.
[Ti] Título:Kidney transplantation fails to provide adequate growth in children with chronic kidney disease born small for gestational age.
[So] Source:Pediatr Nephrol;32(3):511-519, 2017 Mar.
[Is] ISSN:1432-198X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Children with chronic kidney disease are frequently born small for gestational age (SGA) and prone to disproportionately short stature. It is unclear how SGA affects growth after kidney transplantation (KTx). METHODS: Linear growth (height, sitting height, and leg length) was prospectively investigated in a cohort of 322 pediatric KTx recipients, with a mean follow-up of 4.9 years. Sitting height index (ratio of sitting height to total body height) was used to assess body proportions. Predictors of growth outcome in KTx patients with (n = 94) and without (n = 228) an SGA history were evaluated by the use of linear mixed-effects models. RESULTS: Mean z-scores for all linear body dimensions were lower in SGA compared with non-SGA patients (p < 0.001). SGA patients presented with higher target height deficit and degree of body disproportion (p < 0.001). The latter was mainly due to reduced leg growth during childhood. Pubertal trunk growth was diminished in SGA patients, and the pubertal growth spurt of legs was delayed in both groups, resulting in further impairment of adult height, which was more frequently reduced in SGA than in non-SGA patients (50 % vs 18 %, p < 0.001). Use of growth hormone treatment in the pre-transplant period, preemptive KTx, transplant function, and control of metabolic acidosis were the only potentially modifiable correlates of post-transplant growth in SGA groups. By contrast, living related KTx, steroid exposure, and degree of anemia proved to be correlates in non-SGA only. CONCLUSIONS: In children born SGA, growth outcome after KTx is significantly more impaired and affected by different clinical parameters compared with non-SGA patients.
[Mh] Termos MeSH primário: Transtornos do Crescimento/etiologia
Transplante de Rim/métodos
Insuficiência Renal Crônica/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Envelhecimento
Criança
Pré-Escolar
Estudos de Coortes
Feminino
Crescimento
Seres Humanos
Lactente
Recém-Nascido
Recém-Nascido Pequeno para a Idade Gestacional
Perna (Membro)/crescimento & desenvolvimento
Modelos Lineares
Masculino
Estudos Prospectivos
Insuficiência Renal Crônica/complicações
Insuficiência Renal Crônica/patologia
Maturidade Sexual
Tórax/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE
[do] DOI:10.1007/s00467-016-3503-5


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[PMID]:29284780
[Au] Autor:Herrera-Covarrubias D; Coria-Avila G; Hernandez ME; Ismail N
[Ad] Endereço:School of Psychology, University of Ottawa, Ottawa K1N 6N5, ON, Canada.
[Ti] Título:Stress during puberty facilitates precancerous prostate lesions in adult rats.
[So] Source:Exp Oncol;39(4):269-275, 2017 Dec.
[Is] ISSN:1812-9269
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:Puberty can be a critical period for the long-term development of diseases, especially for stress-related disorders that depend on neuroendocrine and immune responses. Some organs like the prostate are prone to diseases that result from neuroendocrine or immune challenges, such as cancer. AIM: In the present study, we assessed the long-term effects of an acute pubertal stressor (immune-challenge) on the development of precancerous lesions in adult rats, and compared them with testosterone-induced prostatic lesions. MATERIALS AND METHODS: Pubertal male rats received a single injection of lipopolysaccharide (LPS) or saline during puberty (5 weeks old). At adulthood (8 weeks old) males were subcutaneously implanted with either an empty capsule or filled with testosterone propionate (100 mg/kg). This resulted in a total of five groups: 1) intact untreated, 2) saline-treated and implanted with a blank capsule, 3) saline-treated and implanted with a testosterone capsule, 4) LPS-treated and implanted with a blank capsule, 5) LPS-treated and implanted with a testosterone capsule. Four weeks later, the rats were sacrified and their prostates processed for histology (hematoxylin and eosin stain) and blood serum processed for hormone analysis (testosterone and corticosterone). RESULTS: Males treated with LPS (stressed during puberty via immune challenge) expressed epithelium dysplasia (specially in the ventral prostate), anisocytosis, presence of mononuclear cells, anisokariosis, non-basal polarity, abnormal nucleus-cytoplasm ratio, proplastic myoepithelium, and granular content in the lumen. These histological alterations were similar, but less severe than those observed in males implanted with testosterone during adulthood. CONCLUSION: These results indicate that pubertal exposure to an immune challenge (stress) facilitates the long-term development of prostatic lesions in adult male rats.
[Mh] Termos MeSH primário: Lesões Pré-Cancerosas
Neoplasias da Próstata
Maturidade Sexual
Estresse Fisiológico
[Mh] Termos MeSH secundário: Animais
Masculino
Lesões Pré-Cancerosas/etiologia
Lesões Pré-Cancerosas/patologia
Neoplasias da Próstata/etiologia
Neoplasias da Próstata/patologia
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE


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[PMID]:28464910
[Au] Autor:Han X; He Y; Zeng G; Wang Y; Sun W; Liu J; Sun Y; Yu J
[Ad] Endereço:Department of Integrative Medicine, Children's Hospital of Fudan University, No.399, Wan Yuan Road, Min Hang District, Shanghai, China.
[Ti] Título:Intracerebroventricular injection of RFRP-3 delays puberty onset and stimulates growth hormone secretion in female rats.
[So] Source:Reprod Biol Endocrinol;15(1):35, 2017 May 02.
[Is] ISSN:1477-7827
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Puberty onset is a complex, organized biological process with multilevel regulation, and its physiopathological mechanisms are yet to be elucidated. RFRP-3, the mammalian ortholog to gonadotropin-inhibitory hormone, is implicated in inhibiting the synthesis and release of gonadotropin in mammals. However, it is unclear whether RFRP-3 participates in regulating pubertal development. METHODS: This study investigated the functional significance and regulatory mechanism of hypothalamic RFRP-3 neuropeptide in the onset of puberty in young female rats. On postnatal day 22, we implanted cannulas into the lateral ventricles of female rat pups. From postnatal day 28 to postnatal day 36, the intracerebroventricular injection of RFRP-3, or vehicle, was conducted twice a day. To investigate whether puberty onset was affected, we examined the body weight, age of vaginal opening, serum hormone levels, uterus and ovary development, and hypothalamic Kiss-1 mRNA expression. RESULTS: Intracerebroventricular injection of RFRP-3 significantly decreased the serum concentrations of luteinizing hormone and estradiol, delayed uterine maturation, and postponed the time of vaginal opening. This study suggests that RFRP-3 can delay the onset of puberty in young female rats; the expression of Kiss-1 mRNA is potently inhibited in the RFRP-3 group. Moreover, our data show that RFRP-3 elevates serum growth hormone levels. CONCLUSIONS: These data suggest that intracerebroventricular injection of RFRP-3 significantly delays the onset of puberty in female rats. Additionally, RFRP-3 may be associated with prepubertal rise in the secretion of growth hormone.
[Mh] Termos MeSH primário: Hormônio do Crescimento/secreção
Neuropeptídeos/administração & dosagem
Maturidade Sexual/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Feminino
Hipotálamo/efeitos dos fármacos
Hipotálamo/metabolismo
Injeções Intraventriculares
Neuropeptídeos/farmacologia
Ratos
Ratos Sprague-Dawley
Via Secretória/efeitos dos fármacos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neuropeptides); 0 (RFamide peptide); 9002-72-6 (Growth Hormone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s12958-017-0254-5


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[PMID]:29315373
[Au] Autor:Wang Z; Shen M; Xue P; DiVall SA; Segars J; Wu S
[Ad] Endereço:Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
[Ti] Título:Female Offspring From Chronic Hyperandrogenemic Dams Exhibit Delayed Puberty and Impaired Ovarian Reserve.
[So] Source:Endocrinology;159(2):1242-1252, 2018 02 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Female offspring of many species exposed to high doses of androgens in utero experience endocrine dysfunction during adulthood. The phenotype of offspring from females with prepregnancy hyperandrogenemia and impaired ovulation, however, has not been examined. We developed a mouse model of hyperandrogenemia by implanting a low-dose dihydrotestosterone (DHT) pellet 15 days before conception. Female offspring born to dams with hyperandrogenemia (DHT daughters) had delayed puberty (P < 0.05) with first estrus on postnatal day (PND) 41 compared with daughters from dams with physiological levels of DHT (non-DHT daughters, PND37.5). Serum follicle-stimulating hormone (FSH) levels in the DHT daughters were fourfold higher (P < 0.05) on PND21, and anti-Müllerian hormone levels were higher (P < 0.05) on PND26 than in non-DHT daughters (controls). DHT daughters showed an extended time in metestrus/diestrus and a shorter time in the proestrus/estrus phase compared with non-DHT daughters (P < 0.05). To examine ovarian response to gonadotropins, superovulation was induced and in vitro fertilization (IVF) was performed. Fewer numbers of oocytes were retrieved from the DHT daughters compared with non-DHT daughters (P < 0.05). At IVF, there was no difference in rates of fertilization or cleavage of oocytes from either group. There were fewer (P < 0.01) primordial follicles (6.5 ± 0.8 vs 14.5 ± 2.1 per ovary) in the ovaries of DHT daughters compared with non-DHT daughters. Daughters from hyperandrogenemic females exhibited elevated prepubertal FSH levels, diminished ovarian response to superovulation, impaired estrous cyclicity, delayed onset of puberty, and reduced ovarian reserve, suggesting that fetal androgen exposure had lasting effects on female reproductive function.
[Mh] Termos MeSH primário: Hiperandrogenismo
Reserva Ovariana/fisiologia
Efeitos Tardios da Exposição Pré-Natal
Insuficiência Ovariana Primária/etiologia
Maturidade Sexual
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Doença Crônica
Feminino
Fertilidade
Hiperandrogenismo/complicações
Hiperandrogenismo/fisiopatologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Gravidez
Efeitos Tardios da Exposição Pré-Natal/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-03078


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[PMID]:29300916
[Au] Autor:Kougias DG; Cortes LR; Moody L; Rhoads S; Pan YX; Juraska JM
[Ad] Endereço:Neuroscience Program, University of Illinois, Champaign, Illinois.
[Ti] Título:Effects of Perinatal Exposure to Phthalates and a High-Fat Diet on Maternal Behavior and Pup Development and Social Play.
[So] Source:Endocrinology;159(2):1088-1105, 2018 02 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Humans are ubiquitously exposed to many phthalates, a class of endocrine-disrupting chemicals commonly used in many consumer goods, and diet, especially fatty food, is presumed to be a major source of exposure. Here, we use a rat model of human prenatal exposure to investigate the potential interactive effects of an environmentally relevant mixture of phthalates and a maternal high-fat diet (HFD). From gestation through postnatal day (P)10, dams consumed the mixture of phthalates (0, 200, or 1000 µg/kg/d) and were fed a control diet or HFD. In males, perinatal exposure to the mixture of phthalates decreased prepubertal body weight and, in a dose-specific manner, periadolescent social play behavior. A dose-specific effect from phthalates with HFD was also seen in increased time alone in females during social play. HFD resulted in dams consuming more calories, having greater gestational weight gain, and licking and nursing their pups more, such that an early postnatal HFD generally increased pup body weight. There also was a tendency for increased oxidative stress markers at P10 within the medial prefrontal cortex of males exposed to the relatively high dose of phthalates and HFD. Effects on gene expression were inconsistent at P10 and P90 in both the medial prefrontal cortex and hypothalamus. Overall, this study demonstrates that phthalates and a maternal HFD only rarely interacted, except in oxidative stress markers in males. Additionally, perinatal exposure to an environmentally relevant mixture of phthalates can have a modest, but lasting, impact on social behaviors in both males and females.
[Mh] Termos MeSH primário: Dieta Hiperlipídica
Crescimento/efeitos dos fármacos
Comportamento Materno/efeitos dos fármacos
Ácidos Ftálicos/toxicidade
Jogos e Brinquedos
Efeitos Tardios da Exposição Pré-Natal
Comportamento Social
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Dieta Hiperlipídica/efeitos adversos
Feminino
Masculino
Fenômenos Fisiológicos da Nutrição Materna
Jogos e Brinquedos/psicologia
Gravidez
Efeitos Tardios da Exposição Pré-Natal/fisiopatologia
Efeitos Tardios da Exposição Pré-Natal/psicologia
Ratos
Ratos Long-Evans
Maturidade Sexual/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Phthalic Acids); 6O7F7IX66E (phthalic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-03047


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[PMID]:29300862
[Au] Autor:Patiño-García D; Cruz-Fernandes L; Buñay J; Palomino J; Moreno RD
[Ad] Endereço:Departamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
[Ti] Título:Reproductive Alterations in Chronically Exposed Female Mice to Environmentally Relevant Doses of a Mixture of Phthalates and Alkylphenols.
[So] Source:Endocrinology;159(2):1050-1061, 2018 02 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Endocrine-disrupting chemicals (EDCs) are exogenous compounds that modify hormone biosynthesis, causing adverse effects to human health. Among them, phthalates and alkylphenols are important due to their wide use in plastics, detergents, personal care products, cosmetics, and food packaging. However, their conjoint effects over reproductive female health have not been addressed. The aim of this work was to test the effect of chronically exposed female mice to a mixture of three phthalates [bis (2-ethylhexyl), dibutyl, and benzyl butyl] and two alkylphenols (4-nonylphenol and 4-tert-octylphenol) from conception to adulthood at environmentally relevant doses. These EDCs were administered in two doses: one below the minimal risk dose to cause adverse effects on human development and reproduction [1 mg/kg body weight (BW)/d of the total mixture] and the other one based on the reference value close to occupational exposure in humans (10 mg/kg BW/d of the total mixture). Our results show that both doses had similar effects regarding the uterus and ovary relative weight, estrous cyclicity, serum levels of progesterone and 17ß-estradiol, and expression of key elements in the steroidogenesis pathway (acute steroidogenic regulatory protein and CYP19A1). However, only the 1-mg/kg BW/d dose delayed the onset of puberty and the transition from preantral to antral follicles, whereas the 10-mg/kg BW/d dose decreased the number of antral follicles and gonadotropin receptor expression. In addition, we observed changes in several fertility parameters in exposed females and in their progeny (F2 generation). In conclusion, our results indicate that chronic exposure to a complex EDC mixture, at environmentally relevant doses, modifies reproductive parameters in female mice.
[Mh] Termos MeSH primário: Disruptores Endócrinos/toxicidade
Exposição Ambiental/efeitos adversos
Fenóis/toxicidade
Ácidos Ftálicos/toxicidade
Reprodução/efeitos dos fármacos
Maturidade Sexual/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Feminino
Exposição Materna/efeitos adversos
Camundongos
Camundongos Endogâmicos C57BL
Gravidez
Efeitos Tardios da Exposição Pré-Natal
Fatores de Tempo
Testes de Toxicidade Crônica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Endocrine Disruptors); 0 (Phenols); 0 (Phthalic Acids); I03GBV4WEL (4-nonylphenol); IOY9FVU3J3 (4-tert-octylphenol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00614


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[PMID]:29293544
[Au] Autor:Takada L; Barbero MMD; Oliveira HN; de Camargo GMF; Fernandes Júnior GA; Aspilcueta-Borquis RR; Souza FRP; Boligon AA; Melo TP; Regatieri IC; Feitosa FLB; Fonseca LFS; Magalhães AFB; Costa RB; Albuquerque LG
[Ad] Endereço:Departamento de Zootecnia-São Paulo State University-UNESP, Jaboticabal, São Paulo, Brazil.
[Ti] Título:Genomic association for sexual precocity in beef heifers using pre-selection of genes and haplotype reconstruction.
[So] Source:PLoS One;13(1):e0190197, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Reproductive traits are of the utmost importance for any livestock farming, but are difficult to measure and to interpret since they are influenced by various factors. The objective of this study was to detect associations between known polymorphisms in candidate genes related to sexual precocity in Nellore heifers, which could be used in breeding programs. Records of 1,689 precocious and non-precocious heifers from farms participating in the Conexão Delta G breeding program were analyzed. A subset of single nucleotide polymorphisms (SNP) located in the region of the candidate genes at a distance of up to 5 kb from the boundaries of each gene, were selected from the panel of 777,000 SNPs of the High-Density Bovine SNP BeadChip. Linear mixed models were used for statistical analysis of early heifer pregnancy, relating the trait with isolated SNPs or with haplotype groups. The model included the contemporary group (year and month of birth) as fixed effect and parent of the animal (sire effect) as random effect. The fastPHASE® and GenomeStudio® were used for reconstruction of the haplotypes and for analysis of linkage disequilibrium based on r2 statistics. A total of 125 candidate genes and 2,024 SNPs forming haplotypes were analyzed. Statistical analysis after Bonferroni correction showed that nine haplotypes exerted a significant effect (p<0.05) on sexual precocity. Four of these haplotypes were located in the Pregnancy-associated plasma protein-A2 gene (PAPP-A2), two in the Estrogen-related receptor gamma gene (ESRRG), and one each in the Pregnancy-associated plasma protein-A gene (PAPP-A), Kell blood group complex subunit-related family (XKR4) and mannose-binding lectin genes (MBL-1) genes. Although the present results indicate that the PAPP-A2, PAPP-A, XKR4, MBL-1 and ESRRG genes influence sexual precocity in Nellore heifers, further studies are needed to evaluate their possible use in breeding programs.
[Mh] Termos MeSH primário: Bovinos/genética
Haplótipos
Seleção Genética
Maturidade Sexual/genética
[Mh] Termos MeSH secundário: Animais
Bovinos/fisiologia
Feminino
Desequilíbrio de Ligação
Polimorfismo de Nucleotídeo Único
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190197



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