Base de dados : MEDLINE
Pesquisa : G07.690.773.875.500 [Categoria DeCS]
Referências encontradas : 285 [refinar]
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[PMID]:28923722
[Au] Autor:Agathokleous E; Paoletti E; Manning WJ; Kitao M; Saitanis CJ; Koike T
[Ad] Endereço:Silviculture & Forest Ecological Studies, Hokkaido University, Sapporo, Hokkaido 060-8589, Japan; Hokkaido Research Center, Forestry and Forest Products Research Institute (FFPRI), Forest Research and Management Organization, 7 Hitsujigaoka, Sapporo, Hokkaido 062-8516, Japan. Electronic address:
[Ti] Título:High doses of ethylenediurea (EDU) as soil drenches did not increase leaf N content or cause phytotoxicity in willow grown in fertile soil.
[So] Source:Ecotoxicol Environ Saf;147:574-584, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Ground-level ozone (O ) levels are nowadays elevated in wide regions of the Earth, causing significant effects on plants that finally lead to suppressed productivity and yield losses. Ethylenediurea (EDU) is a chemical compound which is widely used in research projects as phytoprotectant against O injury. The EDU mode of action remains still unclear, while there are indications that EDU may contribute to plants with nitrogen (N) when the soil is poor in N and the plants have relatively small leaf area. To reveal whether the N content of EDU acts as a fertilizer to plants when the soil is not poor in N and the plants have relatively large total plant leaf area, willow plants (Salix sachalinensis Fr. Schm) were exposed to low ambient O levels and treated ten times (9-day interval) with 200mL soil drench containing 0, 800 or 1600mg EDU L . Fertilizer was added to a nutrient-poor soil, and the plants had an average plant leaf area of 9.1m at the beginning of EDU treatments. Indications for EDU-induced hormesis in maximum electron transport rate (J ) and ratio of intercellular to ambient CO concentration (C :C ) were observed at the end of the experiment. No other EDU-induced effects on leaf greenness and N content, maximum quantum yield of photosystem II (F /F ), gas exchange, growth and matter production suggest that EDU did not act as N fertilizer and did not cause toxicity under these experimental conditions.
[Mh] Termos MeSH primário: Nitrogênio/metabolismo
Compostos de Fenilureia/farmacologia
Folhas de Planta/efeitos dos fármacos
Salix/efeitos dos fármacos
Solo/química
[Mh] Termos MeSH secundário: Poluentes Atmosféricos/toxicidade
Monitoramento Ambiental
Hormese
Japão
Ozônio/toxicidade
Folhas de Planta/crescimento & desenvolvimento
Folhas de Planta/metabolismo
Salix/crescimento & desenvolvimento
Salix/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Phenylurea Compounds); 0 (Soil); 54924-46-8 (ethylene diurea); 66H7ZZK23N (Ozone); N762921K75 (Nitrogen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE


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[PMID]:29385177
[Au] Autor:Dickel F; Münch D; Amdam GV; Mappes J; Freitak D
[Ad] Endereço:Centre of Excellence in Biological Interactions, Department of Biological and Environmental Science, University of Jyvaskyla, Jyvaskyla, Finland.
[Ti] Título:Increased survival of honeybees in the laboratory after simultaneous exposure to low doses of pesticides and bacteria.
[So] Source:PLoS One;13(1):e0191256, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent studies of honeybees and bumblebees have examined combinatory effects of different stressors, as insect pollinators are naturally exposed to multiple stressors. At the same time the potential influences of simultaneously occurring agricultural agents on insect pollinator health remain largely unknown. Due to different farming methods, and the drift of applied agents and manure, pollinators are most probably exposed to insecticides but also bacteria from organic fertilizers at the same time. We orally exposed honeybee workers to sub-lethal doses of the insecticide thiacloprid and two strains of the bacterium Enterococcus faecalis, which can occur in manure from farming animals. Our results show that under laboratory conditions the bees simultaneously exposed to the a bacterium and the pesticide thiacloprid thiacloprid had significant higher survival rates 11 days post exposure than the controls, which surprisingly showed the lowest survival. Bees that were exposed to diet containing thiacloprid showed decreased food intake. General antibacterial activity is increased by the insecticide and the bacteria, resulting in a higher immune response observed in treated individuals compared to control individuals. We thus propose that caloric restriction through behavioural and physiological adaptations may have mediated an improved survival and stress resistance in our tests. However, the decreased food consumption could in long-term also result in possible negative effects at colony level. Our study does not show an additive negative impact of sub-lethal insecticide and bacteria doses, when tested under laboratory conditions. In contrast, we report seemingly beneficial effects of simultaneous exposure of bees to agricultural agents, which might demonstrate a surprising biological capacity for coping with stressors, possibly through hormetic regulation.
[Mh] Termos MeSH primário: Abelhas/efeitos dos fármacos
Abelhas/microbiologia
Enterococcus faecalis/patogenicidade
Inseticidas/toxicidade
Neonicotinoides/toxicidade
Tiazinas/toxicidade
[Mh] Termos MeSH secundário: Animais
Abelhas/fisiologia
Ingestão de Alimentos/efeitos dos fármacos
Hormese
Inseticidas/administração & dosagem
Neonicotinoides/administração & dosagem
Polinização
Estresse Fisiológico
Tiazinas/administração & dosagem
Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insecticides); 0 (Neonicotinoids); 0 (Thiazines); DSV3A944A4 (thiacloprid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191256


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[PMID]:29283232
[Au] Autor:Rybnikova EA; Samoilov MO
[Ti] Título:Current Theory on the Cerebral Mechanisms of Hypoxic PRE- and Postconditioning.
[So] Source:Usp Fiziol Nauk;47(4):3-17, 2016 Oct-Dec.
[Is] ISSN:0301-1798
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:An exposure of the organism to several episodes of mild hypoxia results in the development of brain hypoxic/ischemic tolerance, as well as cross-tolerance to the stressful factors of psychoemotional nature. Such kind of preconditioning by mild hypoxia functions as "alarm signalization" by I.P. Pavlov, preparing the organism and, in particularly, brain to the forthcoming harmful event. Dose-dependent action of hypoxia on the brain can be considered as one particular case of the general phenomenon termed hormesis, or neurohormesis. Endogenous defense processes launched by the hypoxic preconditioning and leading to the development of cerebral tolerance are associated with activation of intracellular signal cascades, transcriptional factors, regulatory proteins and expression of pro-adaptive genes and their products in the susceptible brain regions. Important mechanism of systemic adaptation induced by hypoxic preconditioning includes modifications of pituitary-adrenal axis aimed at enhancement of its adaptive resources. All these components are involved in the neuroprotective processes in three sequential phases - initiation, induction, and expression. Important role belongs also to epigenetic mechanisms controlling the activity of pro-adaptive genes. In contrast to the preconditioning, hypoxic postconditioning is comparatively novel phenomenon and therefore its mechanisms are less studied. The involvement of hypoxia-inducible factor HIF-1, and non-specific protective processes as up-regulation of anti-apoptotic factors and neurotrophines.
[Mh] Termos MeSH primário: Adaptação Fisiológica
Epigênese Genética
Hipóxia/metabolismo
Pós-Condicionamento Isquêmico
Precondicionamento Isquêmico
Neocórtex/fisiologia
[Mh] Termos MeSH secundário: Proteína 1 de Resposta de Crescimento Precoce/genética
Proteína 1 de Resposta de Crescimento Precoce/metabolismo
Hipocampo/fisiologia
Hormese/fisiologia
Seres Humanos
Hipóxia/genética
Hipóxia/fisiopatologia
Subunidade alfa do Fator 1 Induzível por Hipóxia/genética
Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo
Fatores de Crescimento Neural/genética
Fatores de Crescimento Neural/metabolismo
Sistema Hipófise-Suprarrenal/fisiologia
Proteínas Proto-Oncogênicas c-fos/genética
Proteínas Proto-Oncogênicas c-fos/metabolismo
Transdução de Sinais
Estresse Fisiológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (EGR1 protein, human); 0 (Early Growth Response Protein 1); 0 (HIF1A protein, human); 0 (Hypoxia-Inducible Factor 1, alpha Subunit); 0 (Nerve Growth Factors); 0 (Proto-Oncogene Proteins c-fos)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE


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[PMID]:28715457
[Au] Autor:Wang D; Lin Z; Wang T; Ding X; Liu Y
[Ad] Endereço:State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, China.
[Ti] Título:An analogous wood barrel theory to explain the occurrence of hormesis: A case study of sulfonamides and erythromycin on Escherichia coli growth.
[So] Source:PLoS One;12(7):e0181321, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hormesis has aroused much attention during the past two decades and may have great implications on many fields, including toxicology and risk assessment. However, the observation of hormesis remains challenged under laboratory conditions. To determine favorable conditions under which to observe hormesis, we investigated the hormetic responses of Escherichia coli (E. coli) upon exposure of different concentrations of sulfonamides and erythromycin at different time points and in different culture media: Luria-Bertani (LB) broth and Mueller Hinton (MH) broth. Our results reveal that the antibiotics, both individually and combined, produce hormetic effects on E. coli growth in MH broth at the stationary phase, with the maximum stimulatory response increasing with time. However, in LB broth, the hormetic response was not observed, which can be explained by an analogous "wood barrel theory". Our study suggests that the culture medium and time should be taken into consideration in hormetic studies, and compound mixtures should also receive more attention for their potential to induce hormesis.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Eritromicina/farmacologia
Escherichia coli/efeitos dos fármacos
Escherichia coli/crescimento & desenvolvimento
Hormese
Sulfonamidas/farmacologia
[Mh] Termos MeSH secundário: Meios de Cultura
Escherichia coli/fisiologia
Modelos Biológicos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Culture Media); 0 (Sulfonamides); 63937KV33D (Erythromycin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181321


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[PMID]:28622829
[Au] Autor:Chapman KE; Hoffmann GR; Doak SH; Jenkins GJS
[Ad] Endereço:In Vitro Toxicology Group, Institute of Life Science, Swansea University, Swansea, SA2 8PP, UK. Electronic address: K.E.Chapman@swansea.ac.uk.
[Ti] Título:Investigation of J-shaped dose-responses induced by exposure to the alkylating agent N-methyl-N-nitrosourea.
[So] Source:Mutat Res;819:38-46, 2017 Jul.
[Is] ISSN:1873-135X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Hormesis is defined as a biphasic dose-response where biological effects of low doses of a stressor demonstrate the opposite effect to high-dose effects of the same stressor. Hormetic, or J-shaped, dose-response relationships are relatively rarely observed in toxicology, resulting in a limited understanding and even some skepticism of the concept. Low dose-response studies for genotoxicity endpoints have been performed at Swansea University for over a decade. However, no statistically significant decreases below control genotoxicity levels have been detected until recently. A hormetic-style dose-response following a 24h exposure to the alkylating agent N-methyl-N-nitrosourea (MNU) was observed in a previous study for HPRT mutagenesis in the human lymphoblastoid cell line AHH-1. A second recent study demonstrated a J-shaped dose-response for the induction of micronuclei by MNU in a 24h treatment in a similar test system. Following mechanistic investigations, it was hypothesized that p53 may be responsible for the observed hormetic phenomenon. As genotoxic carcinogens are a major causative factor of many cancers, consideration of hormesis in carcinogenesis could be important in safety assessment. The data examined here offer possible insights into hormesis, including its estimated prevalence, underlying mechanisms and lack of generalizability.
[Mh] Termos MeSH primário: Hormese
Metilnitrosoureia/toxicidade
Modelos Teóricos
Mutagênicos/toxicidade
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
DNA Glicosilases/genética
DNA Glicosilases/metabolismo
Metilases de Modificação do DNA/antagonistas & inibidores
Metilases de Modificação do DNA/metabolismo
Enzimas Reparadoras do DNA/antagonistas & inibidores
Enzimas Reparadoras do DNA/metabolismo
Relação Dose-Resposta a Droga
Seres Humanos
Micronúcleos com Defeito Cromossômico/induzido quimicamente
Proteína Supressora de Tumor p53/genética
Proteína Supressora de Tumor p53/metabolismo
Proteínas Supressoras de Tumor/antagonistas & inibidores
Proteínas Supressoras de Tumor/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mutagens); 0 (Tumor Suppressor Protein p53); 0 (Tumor Suppressor Proteins); 684-93-5 (Methylnitrosourea); EC 2.1.1.- (DNA Modification Methylases); EC 2.1.1.63 (MGMT protein, human); EC 3.2.2.- (DNA Glycosylases); EC 6.5.1.- (DNA Repair Enzymes)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170618
[St] Status:MEDLINE


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[PMID]:28520891
[Au] Autor:Wang P; Zhou LL; Yang F; Li M; Liu XM; Wang Y; Lei CL; Si SY
[Ad] Endereço:Institute of Vegetable Wuhan Academy of Agricultural Science and Technology, Wuhan 430345, P. R. China.
[Ti] Título:Sublethal Effects of Thiamethoxam on the Demographic Parameters of Myzus persicae (Hemiptera: Aphididae).
[So] Source:J Econ Entomol;110(4):1750-1754, 2017 Aug 01.
[Is] ISSN:1938-291X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The green peach aphid, Myzus persicae Sulzer (Hemiptera: Aphididae), is an important sap-sucking pest of many crops, including Chinese cabbage, Brassinca oleracea L. The neonicotinoid insecticide thiamethoxam has been used as an effective insecticide to control M. persicae in cabbage fields. In this study, we assessed the effects of sublethal concentrations of thiamethoxam on demographic parameters of M. persicae. In leaf-dip bioassays, thiamethoxam showed a relatively high toxicity against M. persicae with an LC50 of 6.80 mg liter-1. The duration of the preadult stage was not significantly affected in the sublethal bioassay. Additionally, the longevity and adult preoviposition period were not significantly affected by sublethal thiamethoxam. However, sublethal thiamethoxam significantly increased fecundity (LC10) and prolonged the total preoviposition period (LC40). Consequently, the finite rate of increase (λ) and the intrinsic rate of increase (rm) of aphids exposed to the LC40 were significantly lower than those of control aphids, whereas the net reproductive rate (R0) was higher, and the generation time (T) and the population doubling time (DT) were longer in the treated group. Based on these results, hormesis was induced by sublethal thiamethoxam in M. persicae, with the population growth of M. persicae negatively affected at higher sublethal concentrations of thiamethoxam. Therefore, our study indicated that the possible effects of thiamethoxam on aphids require further study to develop optimized integrated pest management strategies.
[Mh] Termos MeSH primário: Afídeos
Hormese/efeitos dos fármacos
Controle de Insetos
Inseticidas
Nitrocompostos
Oxazinas
Tiazóis
[Mh] Termos MeSH secundário: Animais
Demografia
Traços de História de Vida
Neonicotinoides
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Neonicotinoids); 0 (Nitro Compounds); 0 (Oxazines); 0 (Thiazoles); 747IC8B487 (thiamethoxam)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.1093/jee/tox112


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[PMID]:28520791
[Au] Autor:Papanastasiou SA; Bali ED; Ioannou CS; Papachristos DP; Zarpas KD; Papadopoulos NT
[Ad] Endereço:Department of Agriculture, Crop Production and Rural Environment, University of Thessaly, Nea Ionia, Magnisia, Greece.
[Ti] Título:Toxic and hormetic-like effects of three components of citrus essential oils on adult Mediterranean fruit flies (Ceratitis capitata).
[So] Source:PLoS One;12(5):e0177837, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plant essential oils (EOs) and a wide range of their individual components are involved in a variety of biological interactions with insect pests including stimulatory, deterrent, toxic and even hormetic effects. Both the beneficial and toxic properties of citrus EOs on the Mediterranean fruit fly (medfly) have been experimentally evidenced over the last years. However, no information is available regarding the toxic or beneficial effects of the major components of citrus EOs via contact with the adults of the Mediterranean fruit fly. In the present study, we explored the toxicity of limonene, linalool and α-pinene (3 of the main compounds of citrus EOs) against adult medflies and identified the effects of sub-lethal doses of limonene on fitness traits in a relaxed [full diet (yeast and sugar)] and in a stressful (sugar only) feeding environment. Our results demonstrate that all three compounds inferred high toxicity to adult medflies regardless of the diet, with males being more sensitive than females. Sub-lethal doses of limonene (LD20) enhanced the lifespan of adult medflies when they were deprived of protein. Fecundity was positively affected when females were exposed to limonene sub-lethal doses. Therefore, limonene, a major constituent of citrus EOs, induces high mortality at increased doses and positive effects on life history traits of medfly adults through contact at low sub-lethal doses. A hormetic-like effect of limonene to adult medflies and its possible underlying mechanisms are discussed.
[Mh] Termos MeSH primário: Agentes de Controle Biológico/toxicidade
Ceratitis capitata/efeitos dos fármacos
Cicloexenos/toxicidade
Monoterpenos/toxicidade
Óleos Voláteis/toxicidade
Terpenos/toxicidade
[Mh] Termos MeSH secundário: Animais
Ceratitis capitata/fisiologia
Citrus/química
Cicloexenos/análise
Dieta
Feminino
Hormese
Dose Letal Mediana
Masculino
Monoterpenos/análise
Óleos Voláteis/química
Estresse Fisiológico
Terpenos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Control Agents); 0 (Cyclohexenes); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Terpenes); 9MC3I34447 (limonene); D81QY6I88E (linalool); JPF3YI7O34 (alpha-pinene)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177837


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[PMID]:28478379
[Au] Autor:Agathokleous E
[Ad] Endereço:Hokkaido Research Center, Forestry and Forest Products Research Institute (FFPRI), National Research and Development Agency, 7 Hitsujigaoka, Sapporo, Hokkaido 062-8516, Japan; Research Faculty of Agriculture, School of Agriculture, Hokkaido University, Kita 9 Nishi 9, Sapporo, Hokkaido 060-8589, Japan. Electronic address: evgenios@ffpri.affrc.go.jp.
[Ti] Título:Perspectives for elucidating the ethylenediurea (EDU) mode of action for protection against O phytotoxicity.
[So] Source:Ecotoxicol Environ Saf;142:530-537, 2017 Aug.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Ethylenediurea (EDU) has been widely studied for its effectiveness to protect plants against injuries caused by surface ozone (O ), however its mode of action remains unclear. So far, there is not a unified methodological approach and thus the methodology is quite arbitrary, thereby making it more difficult to generalize findings and understand the EDU mode of action. This review examines the question of whether potential N addition to plants by EDU is a fundamental underlying mechanism in protecting against O phytotoxicity. Yet, this review proposes an evidence-based hypothesis that EDU may protect plants against O deleterious effects upon generation of EDU-induced hormesis, i.e. by activating plant defense at low doses. This hypothesis challenges the future research directions. Revealing a hormesis-based EDU mode of action in protecting plants against O toxicity would have further implications to ecotoxicology and environmental safety. Furthermore, this review discusses the need for further studies on plant metabolism under EDU treatment through relevant experimental approach, and attempts to set the bases for approaching a unified methodology that will contribute in revealing the EDU mode of action. In this framework, focus is given to the main EDU application methods.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/toxicidade
Ozônio/toxicidade
Compostos de Fenilureia/farmacologia
Plantas/efeitos dos fármacos
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: Hormese
Compostos de Fenilureia/metabolismo
Plantas/metabolismo
Substâncias Protetoras/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Phenylurea Compounds); 0 (Protective Agents); 54924-46-8 (ethylene diurea); 66H7ZZK23N (Ozone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170508
[St] Status:MEDLINE


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[PMID]:28319746
[Au] Autor:Belz RG; Piepho HP
[Ad] Endereço:University of Hohenheim, Agroecology Unit, Hans-Ruthenberg Institute, 70593, Stuttgart, Germany. Electronic address: regina.belz@uni-hohenheim.de.
[Ti] Título:Predicting biphasic responses in binary mixtures: Pelargonic acid versus glyphosate.
[So] Source:Chemosphere;178:88-98, 2017 Jul.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Predicting hormesis in mixtures is challenging, but essential considering that chemical exposures often occur in mixtures and at low doses. This study investigated mixture effects with two herbicides prone to induce hormesis and to interact, namely pelargonic acid versus glyphosate. Five independent mixture experiments were conducted in vitro to assess effects on root growth of lettuce. Mixture effects on the dose were analyzed using classical joint-action models in terms of deviation from the reference model of concentration addition. For effects on the hormetic magnitude (y ), a linear reference model was utilized. Hormesis was inconsistent across rays, so that effects on inhibitory doses and y could be evaluated, but not effects on hormetic doses. Mixture effects on the dose were additive at lower doses changing to strong high-dose synergism. Mixture effects on y followed a linear change with mixture ratio or significantly deviated from linearity with a one-sided trend across rays in two experiments. The trend was antipodal between experiments, but well described by a curved y model based on single dose-response relationships. Atypical y deviations were associated with strong synergism at ED , suggesting that the linearity model applies for chemicals showing no/minor interaction at ED , while for strongly interacting chemicals y predictions seem more critical. The study unambiguously proved synergism on the dose for pelargonic acid versus glyphosate and indicated an impact of these joint effects on y . The study confirms the predictability of hormesis in mixtures and provides a further methodological step towards an incorporation of hormesis into mixture-toxicity evaluations.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Ácidos Graxos/farmacologia
Glicina/análogos & derivados
Hormese/efeitos dos fármacos
Alface/crescimento & desenvolvimento
Raízes de Plantas/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga
Interações Medicamentosas
Sinergismo Farmacológico
Glicina/farmacologia
Alface/efeitos dos fármacos
Raízes de Plantas/efeitos dos fármacos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Fatty Acids); 4632WW1X5A (glyphosate); 97SEH7577T (pelargonic acid); TE7660XO1C (Glycine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE


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[PMID]:28318788
[Au] Autor:Calabrese EJ
[Ad] Endereço:Department of Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, United States. Electronic address: edwardc@schoolph.umass.edu.
[Ti] Título:Hormesis commonly observed in the assessment of aneuploidy in yeast.
[So] Source:Environ Pollut;225:713-728, 2017 Jun.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Extensive dose response studies have assessed the potential of toxic chemical agents to induce aneuploidy in the yeast model. An assessment of such findings revealed that hormetic-like biphasic dose responses were commonly observed. A preliminary estimate of the frequency of the hormetic responses using a priori entry and evaluative criteria was approximately 65-80%.
[Mh] Termos MeSH primário: Aneuploidia
Hormese
Leveduras/fisiologia
[Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga
Medição de Risco
Leveduras/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE



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