Base de dados : MEDLINE
Pesquisa : G07.690.936 [Categoria DeCS]
Referências encontradas : 9 [refinar]
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  1 / 9 MEDLINE  
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[PMID]:29430905
[Au] Autor:Sbitnev AV; Vodianova MA; Kriatov IA; Donerian LG; Evseeva IS; Ushakova OV; Ushakov DI; Matveeva IS; Rodionova OM
[Ti] Título:[Methodological aspects of the assessment of phytotoxicic properties of ice-melter reagents].
[So] Source:Gig Sanit;95(8):773-8, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:One of the main criteria which determine the possibility of the use of a particular type of ice-melter reagents (IMR) is the degree of their safety for the environment and human health, which is reflected in the establishment of safe doses and concentrations. In this regard, the current area of research is to improve the ecological and epidemiological principles of risk assessment of modern types of anti-icing agents. Currently available data concerning monitoring soil studies and the snow held in various cities of Russia, show that there is a process of accumulation of the main components of IMR - sodium and chlorine ions in the areas related to the roadway. The article is designated a problem of existing methodological approaches to the assessment of the phytotoxic impact in the investigation of anti-icing agents in the laboratory. There was executed the comparative characteristics of the results of the preliminary pilot studies on the phytotoxic properties of IMR under using different substrates for germination of seeds - soil and filter paper. The data obtained are characterized by differences in the degree of phytotoxic action of the same species depending upon ice-melter reagents methodical setting circuit laboratory experiment. As a result, there was shown the imperfection of the existing method of rapid analysis in relation to ice-melter materials (IMM).
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Congelamento
Gelo
Plantas/efeitos dos fármacos
Neve
Cloreto de Sódio
Poluentes do Solo
[Mh] Termos MeSH secundário: Poluição Ambiental/efeitos adversos
Poluição Ambiental/análise
Poluição Ambiental/prevenção & controle
Seres Humanos
Federação Russa
Cloreto de Sódio/química
Cloreto de Sódio/toxicidade
Poluentes do Solo/química
Poluentes do Solo/toxicidade
Solventes/química
Fenômenos Toxicológicos
Transportes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ice); 0 (Soil Pollutants); 0 (Solvents); 451W47IQ8X (Sodium Chloride)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


  2 / 9 MEDLINE  
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[PMID]:27549121
[Au] Autor:Lin R; Yin G
[Ad] Endereço:Department of Statistics and Actuarial Science, The University of Hong Kong, Pokfulam Road, Hong Kong gyin@hku.hk.
[Ti] Título:Nonparametric overdose control with late-onset toxicity in phase I clinical trials.
[So] Source:Biostatistics;18(1):180-194, 2017 Jan.
[Is] ISSN:1468-4357
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Under the framework of Bayesian model selection, we propose a nonparametric overdose control (NOC) design for dose finding in phase I clinical trials. Each dose assignment is guided via a feasibility bound, which thereby can control the number of patients allocated to excessively toxic dose levels. Several aspects of the NOC design are explored, including the coherence property in dose assignment, calibration of design parameters, and selection of the maximum tolerated dose (MTD). We further propose a fractional NOC (fNOC) design in conjunction with a so-called fractional imputation approach, to account for late-onset toxicity outcomes. Extensive simulation studies have been conducted to show that both the NOC and fNOC designs have robust and satisfactory finite-sample performance compared with the existing dose-finding designs. The proposed methods also possess several desirable properties: treating patients more safely and also neutralizing the aggressive escalation to overly toxic doses when the toxicity outcomes are late-onset. The fNOC design is exemplified with a real cancer phase I trial.
[Mh] Termos MeSH primário: Teorema de Bayes
Ensaios Clínicos Fase I como Assunto
Overdose de Drogas/prevenção & controle
Fenômenos Toxicológicos
[Mh] Termos MeSH secundário: Seres Humanos
Dose Máxima Tolerável
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160824
[St] Status:MEDLINE
[do] DOI:10.1093/biostatistics/kxw038


  3 / 9 MEDLINE  
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[PMID]:27474926
[Au] Autor:Ismail T; Shafi S; Singh S; Sidiq T; Khajuria A; Rouf A; Yadav M; Saikam V; Singh PP; Alam MS; Islam N; Sharma K; Kumar HMS
[Ad] Endereço:Medicinal Chemistry Division, Indian Institute of Integrative Medicine, Jammu, India. Electronic address: tabsismail@gmail.com.
[Ti] Título:Synthesis and immunopotentiating activity of novel isoxazoline functionalized coumarins.
[So] Source:Eur J Med Chem;123:90-104, 2016 Nov 10.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:A novel series (13) of isoxazoline functionalized coumarins was synthesized through 1,3-dipolar cyclization of nitrile oxides with Allylated coumarins. Synthesis of effective and target selective immunostimulators through conjugation of diversely substituted isoxazolines and 7-hydroxycoumarins is the focus of the present article. The proposed synthetic scheme was observed to be highly regiospecific yielding attempted conjugates in good yield (>90%). Kinetic resolution of the racemates was carried out by employing lipase B from Candida antarctica (CALB). The synthesized compounds were screened in vitro and in vivo for their biological activities viz. toxicity and impact on splenocyte proliferation (T- and B-cell proliferation), antibody production (HA titre), delayed-type hypersensitivity reaction (DTH), T-cell subtypes (CD4 and CD8), cytokine production (IL-2, IFN-γ, and IL-4) and NO (macrophage) production. Our results establish that isoxazoline functionalized coumarins exhibit excellent immune potentiating activity especially compounds 2, 4 and 8 whose activity is more than that of Levimasole as standard. The structure activity relations are explained in light of the structural/functional aspects of tested compounds. To the best of our knowledge the presented work is first of its kind and is presaged to prove very useful for the design and synthesis of bis-heterocycle based novel, therapeutically selective and effective immunopotentiators.
[Mh] Termos MeSH primário: Adjuvantes Imunológicos/síntese química
Cumarínicos/farmacologia
[Mh] Termos MeSH secundário: Adjuvantes Imunológicos/farmacologia
Animais
Anticorpos/efeitos dos fármacos
Células Cultivadas
Cumarínicos/síntese química
Cumarínicos/química
Citocinas/efeitos dos fármacos
Seres Humanos
Hipersensibilidade Tardia/tratamento farmacológico
Sistema Imunitário/efeitos dos fármacos
Isoxazóis/química
Linfócitos/efeitos dos fármacos
Relação Estrutura-Atividade
Fenômenos Toxicológicos/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Antibodies); 0 (Coumarins); 0 (Cytokines); 0 (Isoxazoles)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160731
[St] Status:MEDLINE


  4 / 9 MEDLINE  
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[PMID]:26952164
[Au] Autor:Remez N; Garcia-Serna R; Vidal D; Mestres J
[Ad] Endereço:Systems Pharmacology, Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical Research Institute and University Pompeu Fabra, Parc de Recerca Biomèdica , Doctor Aiguader 88, 08003 Barcelona, Catalonia, Spain.
[Ti] Título:The In Vitro Pharmacological Profile of Drugs as a Proxy Indicator of Potential In Vivo Organ Toxicities.
[So] Source:Chem Res Toxicol;29(4):637-48, 2016 Apr 18.
[Is] ISSN:1520-5010
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The potential of a drug to cause certain organ toxicities is somehow implicitly contained in its full pharmacological profile, provided the drug reaches and accumulates at the various organs where the different interacting proteins in its profile, both targets and off-targets, are expressed. Under this assumption, a computational approach was implemented to obtain a projected anatomical profile of a drug from its in vitro pharmacological profile linked to protein expression data across 47 organs. It was observed that the anatomical profiles obtained when using only the known primary targets of the drugs reflected roughly the intended organ targets. However, when both known and predicted secondary pharmacology was considered, the projected anatomical profiles of the drugs were able to clearly highlight potential organ off-targets. Accordingly, when applied to sets of drugs known to cause cardiotoxicity and hepatotoxicity, the approach is able to identify heart and liver, respectively, as the organs where the proteins in the pharmacological profile of the corresponding drugs are specifically expressed. When applied to a set of drugs linked to a risk of Torsades de Pointes, heart is again the organ clearly standing out from the rest and a potential protein profile hazard is proposed. The approach can be used as a proxy indicator of potential in vivo organ toxicities.
[Mh] Termos MeSH primário: Cardiotoxicidade/etiologia
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Torsades de Pointes/induzido quimicamente
Fenômenos Toxicológicos
[Mh] Termos MeSH secundário: Cardiotoxicidade/genética
Doença Hepática Induzida por Substâncias e Drogas/genética
Biologia Computacional/métodos
Coração/efeitos dos fármacos
Seres Humanos
Fígado/efeitos dos fármacos
Fígado/metabolismo
Miocárdio/metabolismo
Risco
Torsades de Pointes/genética
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160309
[St] Status:MEDLINE
[do] DOI:10.1021/acs.chemrestox.5b00470


  5 / 9 MEDLINE  
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[PMID]:26506572
[Au] Autor:Wexler P; Judson R; de Marcellus S; de Knecht J; Leinala E
[Ad] Endereço:National Library of Medicine (NLM), Toxicology and Environmental Health Information Program, USA.
[Ti] Título:Health effects of toxicants: Online knowledge support.
[So] Source:Life Sci;145:284-93, 2016 Jan 15.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Research in toxicology generates vast quantities of data which reside on the Web and are subsequently appropriated and utilized to support further research. This data includes a broad spectrum of information about chemical, biological and radiological agents which can affect health, the nature of the effects, treatment, regulatory measures, and more. Information is structured in a variety of formats, including traditional databases, portals, prediction models, and decision making support tools. Online resources are created and housed by a variety of institutions, including libraries and government agencies. This paper focuses on three such institutions and the tools they offer to the public: the National Library of Medicine (NLM) and its Toxicology and Environmental Health Information Program, the United States Environmental Protection Agency (EPA), and the Organisation for Economic Co-operation and Development (OECD). Reference is also made to other relevant organizations.
[Mh] Termos MeSH primário: Bases de Dados Factuais
National Library of Medicine (U.S.)
Organização para a Cooperação e Desenvolvimento Econômico
Fenômenos Toxicológicos
Toxicologia
United States Environmental Protection Agency
[Mh] Termos MeSH secundário: Saúde Ambiental
Europa (Continente)
Saúde
Seres Humanos
Internet
Toxicologia/métodos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170118
[Lr] Data última revisão:
170118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151028
[St] Status:MEDLINE


  6 / 9 MEDLINE  
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[PMID]:26158312
[Au] Autor:Dame ZT; Silima B; Gryzenhout M; van Ree T
[Ad] Endereço:a Department of Organic and Biomolecular Chemistry , University of Göttingen , Tammannstraße 2, D-37077 Göttingen , Germany.
[Ti] Título:Bioactive compounds from the endophytic fungus Fusarium proliferatum.
[So] Source:Nat Prod Res;30(11):1301-4, 2016 Jun.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The crude extract of an endophytic fungus isolated from Syzygium cordatum and identified as Fusarium proliferatum showed 100% cytotoxicity against the brine shrimp Artemia salina at 100 µg/mL. Seven coloured, biologically active metabolites - including ergosta-5,7,22-trien-3ß-ol, nectriafurone-8-methyl ether, 9-O-methyl fusarubin, bostrycoidin, bostrycoidin-9-methyl ether and 8-hydroxy-5,6-dimethoxy-2-methyl-3-(2-oxo-propyl)-1,4-naphthoquinone- were isolated from the extract.
[Mh] Termos MeSH primário: Artemia/efeitos dos fármacos
Fusarium/química
[Mh] Termos MeSH secundário: Animais
Cor
Fusarium/metabolismo
Isoquinolinas/isolamento & purificação
Extração Líquido-Líquido
Naftoquinonas/isolamento & purificação
Fenômenos Toxicológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Isoquinolines); 0 (Naphthoquinones); 4589-33-7 (bostrycoidin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150710
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1053089


  7 / 9 MEDLINE  
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[PMID]:26226450
[Au] Autor:MacDonald TC; Nehzati S; Sylvain NJ; James AK; Korbas M; Caine S; Pickering IJ; George GN; Krone PH
[Ad] Endereço:Molecular and Environmental Science Research Group, Department of Geological Sciences, University of Saskatchewan, Saskatoon, SK S7N 5E2, Canada; Toxicology Centre, University of Saskatchewan, Saskatoon, SK S7N 5B3, Canada; Department of Anatomy and Cell Biology, University of Saskatchewan, Saskatoo
[Ti] Título:Phenylthiourea alters toxicity of mercury compounds in zebrafish larvae.
[So] Source:J Inorg Biochem;151:10-7, 2015 Oct.
[Is] ISSN:1873-3344
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In recent years larval stage zebrafish have been emerging as a standard vertebrate model in a number of fields, ranging from developmental biology to pharmacology and toxicology. The tyrosinase inhibitor 1-phenyl-2-thiourea (PTU) is used very widely with larval zebrafish to generate essentially transparent organisms through inhibition of melanogenesis, which has enabled many elegant studies in areas ranging from neurological development to cancer research. Here we show that PTU can have dramatic synergistic and antagonistic effects on the chemical toxicology of different mercury compounds. Our results indicate that extreme caution should be used when employing PTU in toxicological studies, particularly when studying toxic metal ions.
[Mh] Termos MeSH primário: Compostos de Mercúrio/toxicidade
Feniltioureia/farmacologia
Fenômenos Toxicológicos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Complexos de Coordenação/química
Ativação Enzimática/efeitos dos fármacos
Compostos de Mercúrio/química
Feniltioureia/química
Teoria Quântica
Peixe-Zebra
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coordination Complexes); 0 (Mercury Compounds); 6F82C6Q54C (Phenylthiourea)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150731
[St] Status:MEDLINE


  8 / 9 MEDLINE  
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[PMID]:26020217
[Au] Autor:Taylor JB; Smith DJ
[Ti] Título:Continuous, low-dose oral exposure to sodium chlorate reduces fecal generic Escherichia coli in sheep feces without inducing clinical chlorate toxicosis.
[So] Source:J Anim Sci;93(4):1942-51, 2015 Apr.
[Is] ISSN:1525-3163
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Our objectives were to determine an effective, yet safe, daily dose of sodium chlorate for reducing fecal shedding of generic Escherichia coli in mature ewes. In a completely randomized experimental design, 25 Targhee ewes (age ∼ 18 mo; BW = 62.5 ± 7.3 kg, mean ± SD) were assigned randomly to 1 of 5 sodium chlorate treatments, which were administered in the drinking water for 5 consecutive days. Treatments were control group (no sodium chlorate) and 4 targeted levels of daily sodium chlorate intake: 30, 60, 90, and 120 mg · kg(-1) BW · d(-1) for 5 d. Individual ewe ad libitum intake of water (with treatments) was measured daily, and BW was measured at the beginning of and 15 and 51 d after the 5-d treatment period. Serum chlorate, whole blood methemoglobin and packed-cell volume (PCV), and fecal generic E. coli and general Enterobacteriaceae coliforms were measured from corresponding samples collected at the end of the 5-d treatment period. Average daily intakes of sodium chlorate from drinking water treatments were 95%, 91%, 90%, and 83% of the target treatment intakes of 30, 60, 90, and 120 mg · kg(-1) BW · d(-1), respectively. Daily sodium chlorate intake remained constant for all treatment groups except for ewes offered 120 mg NaClO3 · kg(-1) BW · d(-1), which decreased (quadratic; P = 0.04) over the course of the 5-d treatment period. This decrease in sodium chlorate intake indicated that the 120-mg NaClO3 level may have induced either toxicity and/or an aversion to the drinking water treatment. Serum chlorate concentrations increased (quadratic; P < 0.001) with increasing sodium chlorate intake. At the end of the 5-d treatment period, mean (least squares ± SEM) serum chlorate concentrations for ewes offered 30, 60, 90, and 120 mg NaClO3 · kg(-1) BW · d(-1) were 15.6 ± 14.1, 32.8 ± 15.8, 52.9 ± 14.1, and 90.3 ± 14.1 µg/mL, respectively. Whole blood methemoglobin and PCV were similar (P = 0.31 to 0.81) among the control group and ewes offered sodium chlorate. Likewise, BW was not affected by sodium chlorate (P > 0.27). Ewes consuming approximately 55 mg NaClO3 · kg(-1) BW · d(-1) or more (i.e., ewes offered 60, 90, and 120 mg) had a >1.4 log unit reduction in fecal E. coli and Enterobacteriaceae coliforms compared with control ewes. We suggest that for a short-term, 5-d dosing strategy, 55 to 81 mg NaClO3 · kg(-1) BW · d(-1) is an effective, yet safe, daily oral dose range for mature ewes to achieve a 97% to 99% reduction in fecal shedding of generic E. coli.
[Mh] Termos MeSH primário: Cloratos/toxicidade
Infecções por Escherichia coli/veterinária
Escherichia coli/efeitos dos fármacos
Fezes/microbiologia
Doenças dos Ovinos/tratamento farmacológico
Carneiro Doméstico/microbiologia
[Mh] Termos MeSH secundário: Administração Oral
Criação de Animais Domésticos/métodos
Animais
Peso Corporal/efeitos dos fármacos
Cloratos/administração & dosagem
Cloratos/sangue
Cloratos/farmacologia
Cloratos/uso terapêutico
Relação Dose-Resposta a Droga
Infecções por Escherichia coli/tratamento farmacológico
Feminino
Herbicidas/administração & dosagem
Herbicidas/farmacologia
Herbicidas/uso terapêutico
Metemoglobina/metabolismo
Ovinos
Doenças dos Ovinos/microbiologia
Carneiro Doméstico/fisiologia
Fenômenos Toxicológicos/efeitos dos fármacos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Chlorates); 0 (Herbicides); 9008-37-1 (Methemoglobin); T95DR77GMR (sodium chlorate)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150529
[Lr] Data última revisão:
150529
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150529
[St] Status:MEDLINE
[do] DOI:10.2527/jas.2014-8568


  9 / 9 MEDLINE  
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[PMID]:25694074
[Au] Autor:Kleandrova VV; Luan F; Speck-Planche A; Cordeiro MN
[Ti] Título:In silico assessment of the acute toxicity of chemicals: recent advances and new model for multitasking prediction of toxic effect.
[So] Source:Mini Rev Med Chem;15(8):677-86, 2015.
[Is] ISSN:1875-5607
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The assessment of acute toxicity is one of the most important stages to ensure the safety of chemicals with potential applications in pharmaceutical sciences, biomedical research, or any other industrial branch. A huge and indiscriminate number of toxicity assays have been carried out on laboratory animals. In this sense, computational approaches involving models based on quantitative-structure activity/toxicity relationships (QSAR/QSTR) can help to rationalize time and financial costs. Here, we discuss the most significant advances in the last 6 years focused on the use of QSAR/QSTR models to predict acute toxicity of drugs/chemicals in laboratory animals, employing large and heterogeneous datasets. The advantages and drawbacks of the different QSAR/QSTR models are analyzed. As a contribution to the field, we introduce the first multitasking (mtk) QSTR model for simultaneous prediction of acute toxicity of compounds by considering different routes of administration, diverse breeds of laboratory animals, and the reliability of the experimental conditions. The mtk-QSTR model was based on artificial neural networks (ANN), allowing the classification of compounds as toxic or non-toxic. This model correctly classified more than 94% of the 1646 cases present in the whole dataset, and its applicability was demonstrated by performing predictions of different chemicals such as drugs, dietary supplements, and molecules which could serve as nanocarriers for drug delivery. The predictions given by the mtk-QSTR model are in very good agreement with the experimental results.
[Mh] Termos MeSH primário: Simulação por Computador
Descoberta de Drogas
Modelos Biológicos
Redes Neurais (Computação)
Relação Quantitativa Estrutura-Atividade
Fenômenos Toxicológicos
[Mh] Termos MeSH secundário: Animais
Fármacos Anti-HIV/toxicidade
Antiprotozoários/toxicidade
Bases de Dados de Produtos Farmacêuticos
Descoberta de Drogas/métodos
Fulerenos/toxicidade
Compostos Heterocíclicos/toxicidade
Seres Humanos
Modelos Moleculares
Preparações Farmacêuticas/administração & dosagem
Tiamina/toxicidade
Tinidazol/toxicidade
Complexo Vitamínico B/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-HIV Agents); 0 (Antiprotozoal Agents); 0 (Fullerenes); 0 (Heterocyclic Compounds); 0 (Pharmaceutical Preparations); 033KF7V46H (Tinidazole); 12001-76-2 (Vitamin B Complex); 155148-31-5 (JM 3100); 182024-42-6 (fullerenol); X66NSO3N35 (Thiamine)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150501
[Lr] Data última revisão:
150501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150220
[St] Status:MEDLINE



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