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[PMID]:29297641
[Au] Autor:Kolesnikova LI; Madaeva IM; Semenova NV; Osipova EV; Darenskaya MA
[Ti] Título:Gender Features of Radical Oxidation of Lipids in Menopausal Women and Men in Andropause.
[So] Source:Vestn Ross Akad Med Nauk;71(3):248-54, 2016.
[Is] ISSN:0869-6047
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:Aims: Our aim was to assess lipid peroxidation ­ antioxidant protection in menopausal women and men in andropause and to compare these processes in different gender and age groups. Materials and Methods: 74 women and 37 men were examined. This study was a prospective, randomized cohort study. Women were divided into perimenopausal group (n=22, mean age 49.03±3.13), postmenopausal group (n=15, mean age 54.43±4.54) and control (n=37, mean age 34±1.2). Men were divided into a group of andropause (n=20, mean age 50.38±2.63) and control (n=17, mean age 35.21±4.75). Body mass index in the main and control groups was comparable. Questionnaires, clinical examination, assessment of the lipid peroxidation-antioxidant defense system, and the calculation of oxidative stress ratio were conducted to all participants of the study. Results: In women from the reproductive phase transition to its extinction increases content of compounds with conjugated double bonds by 22% (p<0.05) in perimenopause and by 27% (p<0.05) in postmenopause, increases content of the ketodienes and coupled trienes by 21% (p<0.05) in perimenopause relative to the control group and reduced by 27% (p<0.05) in postmenopausal women relative to the group of perimenopause. The antioxidant system in women observed the following changes: decrease in the α-tocopherol levels in postmenopausal women by 37% relative to control and by 22% (p<0.05) to compare perimenopause; reduction of retinol level by 29% (p<0.05) in the perimenopause and by 39% (p<0.05) in postmenopause relative to control, increasing of the content of GSSG by 18% (p<0.05) in postmenopause to compare control. When comparing groups of men statistically significant differences were not found. When comparing the groups according to gender, we revealed in men the increased content of compounds with conjugated double bonds by 38% (p<0.05), the GSSG by 13% (p<0.05), reduced content of the ketodienes and coupled trienes by 43% (p<0,05), α-tocopherol by 24% (p<0.05), SOD activity by 9% (p<0.05).Coefficient oxidative stress in perimenopausal women was 2,5, in postmenopausal ­ 3,48, in andropause ­ 0,97. Conclusions: Expressed lipid peroxidation activity is more physiological in andropause than in menopause. Men in andropause have large functional reserves and adaptive capacity than menopausal women.
[Mh] Termos MeSH primário: Andropausa/fisiologia
Peroxidação de Lipídeos
Menopausa/fisiologia
Estresse Oxidativo/fisiologia
[Mh] Termos MeSH secundário: Antioxidantes/metabolismo
Índice de Massa Corporal
Feminino
Seres Humanos
Metabolismo dos Lipídeos
Masculino
Meia-Idade
Estatística como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antioxidants)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.15690/vramn629


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[PMID]:28363155
[Au] Autor:Gupta S; Pandey D; Mandalapu D; Sharma V; Shukla M; Singh S; Singh N; Yadav SK; Tanpula DK; Singh S; Maikhuri JP; Shukla S; Lal J; Siddiqi MI; Gupta G; Sharma VL
[Ad] Endereço:Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi 110001, India.
[Ti] Título:Novel aryl piperazines for alleviation of 'andropause' associated prostatic disorders and depression.
[So] Source:Eur J Med Chem;132:204-218, 2017 May 26.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:A series of seventeen piperazine derivatives have been synthesized and biologically evaluated for the management of andropause-associated prostatic disorders and depression. Five compounds 16, 19, 20, 21 and 22 significantly inhibited proliferation of androgen-sensitive LNCaP prostatic cell line with EC values of 12.4 µM, 15.6 µM, 11.8 µM, 10.4 µM, 12.2 µM respectively and decreased Ca entry through adrenergic-receptor α blocking activity. Anti-androgenic behaviour of compound 19 and 22 was evident by decreased luciferase activity. The high EC value in AR-negative cells PC3 and DU145 suggested that the cytotoxicity of compounds was due to AR down regulation. Compound 19 reduced the prostate weight of rats by 53.8%. Further, forced-swimming and tail-suspension tests revealed antidepressant-like activity of compound 19, lacking effects on neuromuscular co-ordination. In silico ADMET predictions revealed that the compound 19 had good oral absorption, aqueous solubility, non-hepatotoxic and good affinity for plasma protein binding. Pharmacokinetic and tissue uptake of 19 at 10 mg/kg demonstrated an oral bioavailability of 35.4%. In silico docking studies predicted similar binding pattern of compound 19 on androgen receptor as hydroxyflutamide. Compound 19 appears to be a unique scaffold with promising activities against androgen associated prostatic disorders in males like prostate cancer and BPH and associated depression.
[Mh] Termos MeSH primário: Antagonistas de Androgênios/síntese química
Andropausa
Depressão/tratamento farmacológico
Piperazinas/farmacocinética
Doenças Prostáticas/tratamento farmacológico
[Mh] Termos MeSH secundário: Antagonistas de Androgênios/farmacologia
Animais
Linhagem Celular
Regulação para Baixo/efeitos dos fármacos
Seres Humanos
Masculino
Simulação de Acoplamento Molecular
Piperazinas/síntese química
Piperazinas/química
Ratos
Receptores Androgênicos/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androgen Antagonists); 0 (Piperazines); 0 (Receptors, Androgen); 1RTM4PAL0V (piperazine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE


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[PMID]:27929734
[Au] Autor:Abootalebi M; Kargar M; Aminsharifi A
[Ad] Endereço:a Department of Community Health Nursing , School of Nursing and Midwifery, Shiraz University of Medical Sciences , Shiraz , Iran.
[Ti] Título:Assessment of the validity and reliability of a questionnaire on knowledge and attitude of general practitioners about andropause.
[So] Source:Aging Male;20(1):60-64, 2017 Mar.
[Is] ISSN:1473-0790
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVE: Andropause is one of the clinical and biochemical syndromes in aging men associated with the decrease in serum testosterone levels. With the increase in aging male population, life span in Iran, and focus on quality of life, andropause will become a major health issue that needs to be addressed in order to prevent disability. General practitioners, as the first level of health care providers, are in the best position to assess their knowledge and attitude about andropause period, so a structured instrument is necessary to assess them. This study aimed at the assessment of the validity and reliability of the self-made questionnaire on knowledge and attitude of general practitioners about andropause. METHOD: This is a descriptive study done on 402 general physicians working in public and private sectors. The instrument used was a self-administered questionnaire that was developed based on the literature review and recourses available on andropause and was designed to find out the level of knowledge and attitude of andropause. In order to determine the content and face validity of the questionnaire, judgments of experts were used. Cronbach's coefficient was used to determine the reliability of the questionnaire. SPSS 18 (SPSS Inc, Chicago, IL) was used to analyze the data. RESULTS: Content and face validity of the questionnaire was confirmed by experts. The reliability was confirmed by Cronbach's alpha of (0).895 for the part on knowledge and (0).839 for the part on attitude. CONCLUSION: Based on the results of the study, this questionnaire had appropriate validity and reliability to assess the knowledge and attitude of general practitioners about andropause.
[Mh] Termos MeSH primário: Andropausa
Clínicos Gerais
Conhecimentos, Atitudes e Prática em Saúde
Inquéritos e Questionários/normas
[Mh] Termos MeSH secundário: Adulto
Atitude Frente à Saúde
Seres Humanos
Masculino
Meia-Idade
Pesquisa Qualitativa
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161209
[St] Status:MEDLINE
[do] DOI:10.1080/13685538.2016.1188067


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[PMID]:27621230
[Au] Autor:Stute P; Ceausu I; Depypere H; Lambrinoudaki I; Mueck A; Pérez-López FR; van der Schouw YT; Senturk LM; Simoncini T; Stevenson JC; Rees M
[Ad] Endereço:Department of Obstetrics and Gynecology, University Women's Hospital, Bern, Switzerland. Electronic address: stutepe@web.de.
[Ti] Título:A model of care for healthy menopause and ageing: EMAS position statement.
[So] Source:Maturitas;92:1-6, 2016 Oct.
[Is] ISSN:1873-4111
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Worldwide, the number of menopausal women is increasing. They present with complex medical issues that lie beyond the traditional scope of gynaecologists and general practitioners (GPs). The European Menopause and Andropause Society (EMAS) therefore provides a holistic model of care for healthy menopause (HM). The HM healthcare model's core consists of a lead clinician, specialist nurse(s) and the woman herself, supported by an interdisciplinary network of medical experts and providers of alternative/complementary medicine. As HM specialist teams are scarce in Europe, they are also responsible for structuring and optimizing processes in primary care (general gynaecologists and GPs) and secondary care (HM specialists). Activities for accreditation of the subspecialty Women's Health are encouraged.
[Mh] Termos MeSH primário: Envelhecimento
Menopausa
Atenção Primária à Saúde
Saúde da Mulher
[Mh] Termos MeSH secundário: Andropausa
Europa (Continente)
Feminino
Seres Humanos
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160914
[St] Status:MEDLINE


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Texto completo SciELO Chile
[PMID]:27401394
[Au] Autor:Cortés ME; Bernal YA; Vigil P
[Ti] Título:[Andropause and vulnerability in health: when do we start to educate men and health professionals?].
[Ti] Título:Andropausia y vulnerabilidad en salud: ¿cuándo empezamos a educar a los hombres y a los profesionales de la salud?.
[So] Source:Rev Med Chil;144(4):541-3, 2016 Apr.
[Is] ISSN:0717-6163
[Cp] País de publicação:Chile
[La] Idioma:spa
[Mh] Termos MeSH primário: Andropausa
Educação em Saúde/tendências
Pessoal de Saúde/educação
Saúde do Homem/tendências
[Mh] Termos MeSH secundário: Chile
Conhecimentos, Atitudes e Prática em Saúde
Seres Humanos
Masculino
Populações Vulneráveis
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160713
[St] Status:MEDLINE


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[PMID]:27241810
[Au] Autor:Dutta D; Dharmshaktu P; Aggarwal A; Gaurav K; Bansal R; Devru N; Garga UC; Kulshreshtha B
[Ad] Endereço:Department of Endocrinology, Post-graduate Institute of Medical Education and Research (PGIMER) and Dr. Ram Manohar Lohia (RML) Hospital, New Delhi, India.
[Ti] Título:Severity and pattern of bone mineral loss in endocrine causes of osteoporosis as compared to age-related bone mineral loss.
[So] Source:J Postgrad Med;62(3):162-9, 2016 Jul-Sep.
[Is] ISSN:0972-2823
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Data are scant on bone health in endocrinopathies from India. This study evaluated bone mineral density (BMD) loss in endocrinopathies [Graves' disease (GD), type 1 diabetes mellitus (T1DM), hypogonadotrophic hypogonadism (HypoH), hypergonadotropic hypogonadism (HyperH), hypopituitarism, primary hyperparathyroidism (PHPT)] as compared to age-related BMD loss [postmenopausal osteoporosis (PMO), andropause]. MATERIALS AND METHODS: Retrospective audit of records of patients >30 years age attending a bone clinic from August 2014 to January 2016 was done. RESULTS: Five-hundred and seven records were screened, out of which 420 (females:male = 294:126) were analyzed. A significantly higher occurrence of vitamin D deficiency and insufficiency was noted in T1DM (89.09%), HyperH (85%), and HypoH (79.59%) compared to age-related BMD loss (60.02%; P < 0.001). The occurrence of osteoporosis among females and males was 55.41% and 53.97%, respectively, and of osteopenia among females and males was 28.91% and 32.54%, respectively. In females, osteoporosis was significantly higher in T1DM (92%), HyperH (85%), and HypoH (59.26%) compared to PMO (49.34%; P < 0.001). Z score at LS, TF, NOF, and greater trochanter (GT) was consistently lowest in T1DM women. Among men, osteoporosis was significantly higher in T1DM (76.67%) and HypoH (54.55%) compared to andropause (45.45%; P = 0.001). Z score at LS, TF, NOF, GT, and TR was consistently lowest in T1DM men. In GD, the burden of osteoporosis was similar to PMO and andropause. BMD difference among the study groups was not significantly different after adjusting for body mass index (BMI) and vitamin D. CONCLUSION: Low bone mass is extremely common in endocrinopathies, warranting routine screening and intervention. Concomitant vitamin D deficiency compounds the problem. Calcium and vitamin D supplementations may improve bone health in this setting.
[Mh] Termos MeSH primário: Envelhecimento
Densidade Óssea
Doença de Graves/complicações
Osteoporose/complicações
Deficiência de Vitamina D/complicações
[Mh] Termos MeSH secundário: Absorciometria de Fóton
Adulto
Fatores Etários
Idoso
Andropausa
Diabetes Mellitus Tipo 2/epidemiologia
Feminino
Doença de Graves/epidemiologia
Seres Humanos
Índia
Masculino
Meia-Idade
Osteoporose/epidemiologia
Osteoporose/metabolismo
Ossos Pélvicos/metabolismo
Ossos Pélvicos/fisiopatologia
Pós-Menopausa
Prevalência
Estudos Retrospectivos
Índice de Gravidade de Doença
Deficiência de Vitamina D/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160601
[St] Status:MEDLINE
[do] DOI:10.4103/0022-3859.183170


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[PMID]:26951517
[Au] Autor:Ajdzanovic VZ; Jaric IM; Zivanovic JB; Filipovic BR; Sosic-Jurjevic BT; Ristic NM; Stankovic SD; Milosevic VLj
[Ad] Endereço:Department of Cytology, Institute for Biological Research "Sinisa Stankovic", University of Belgrade, Belgrade, Serbia. avlada@ibiss.bg.ac.rs.
[Ti] Título:Histological parameters of the adrenal cortex after testosterone application in a rat model of the andropause.
[So] Source:Histol Histopathol;31(11):1209-20, 2016 Nov.
[Is] ISSN:1699-5848
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:Histological analysis of the adrenal cortex, after testosterone application in a rat model of the andropause, was the main subject of the present study. Middle-aged Wistar rats were divided into sham-operated (SO; n=8), orchidectomized (Orx; n=8) and testosterone treated orchidectomized (Orx+T; n=8) groups. Testosterone propionate (5 mg/kg b.w. /day) was administered for three weeks, while SO and Orx groups received the vehicle alone. Histological objectives were achieved using stereology, histochemistry and steroid receptor immunostaining. The concentrations of testosterone, aldosterone, corticosterone and DHEA were determined by immunoassays. Expectedly, increased (p<0.05) serum concentration of testosterone was observed in Orx+T group. The volume of ZG cells and nuclei increased in Orx+T animals by 50% and 25% (p<0.05) respectively, but the serum concentrations of aldosterone decreased (p<0.05) by 60%, all compared to the same parameters in Orx group. The immunostaining for androgen receptors (ARs) suggested their cytoplasmic localization in ZG cells of Orx+T rats. Volume of the ZF cell nuclei in Orx+T group decreased (p<0.05) by 17%, which was followed by the significant (p<0.05) fall in corticosterone production and secretion, all in comparison with Orx animals. Also, nuclear immunolocalization of ARs of high optical density was observed through the ZF of Orx+T group. In Orx+T rats volume of ZR cells and nuclei, and circulating DHEA concentration increased (p<0.05) by 68%, 22% and about 6.6 times respectively, compared to Orx animals. Besides the extra-receptor actions in adrenal cortex, testosterone supposedly affects some steroidogenesis-related gene expression, as indicated by centripetal rise in the number of nuclear ARs.
[Mh] Termos MeSH primário: Córtex Suprarrenal/efeitos dos fármacos
Andropausa
Testosterona/farmacologia
[Mh] Termos MeSH secundário: Córtex Suprarrenal/metabolismo
Animais
Modelos Animais de Doenças
Imuno-Histoquímica
Masculino
Orquiectomia
Distribuição Aleatória
Ratos
Ratos Wistar
Receptores Androgênicos/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Androgen); 3XMK78S47O (Testosterone)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170414
[Lr] Data última revisão:
170414
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160309
[St] Status:MEDLINE
[do] DOI:10.14670/HH-11-749


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[PMID]:26714462
[Au] Autor:Hirokawa K; Taniguchi T; Fujii Y; Takaki J; Tsutsumi A
[Ad] Endereço:Department of Nursing, Baika Women's University, 2-19-5 Shukunosho, Ibaraki, Osaka, 567-8578, Japan. k-umi@umin.ac.jp.
[Ti] Título:Modification Effects of Changes in Job Demands on Associations Between Changes in Testosterone Levels and Andropause Symptoms: 2-Year Follow-up Study in Male Middle-Aged Japanese Workers.
[So] Source:Int J Behav Med;23(4):464-72, 2016 08.
[Is] ISSN:1532-7558
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of this longitudinal study was to ascertain if changes in job demands modify associations between changes in testosterone levels and andropause symptoms in male Japanese workers. METHOD: A baseline survey including job demands and the Aging Males' Symptoms scale, lifestyle factors, and blood levels of testosterone was conducted in 2007. Among 192 men (mean age ± SD 52.2 ± 7.6 years) who completed all relevant questionnaires and provided blood at baseline, 104 men (50.9 ± 7.2 years) were followed up in 2009. Changes of variables in 2 years were calculated (data of follow-up minus those of baseline). RESULTS: Testosterone levels were increased significantly, whereas job demands and somatic symptoms were reduced significantly, at follow-up. Changes in testosterone levels were negatively associated with changes in total andropause symptoms, psychological symptoms, and sexual symptoms (standardized ß = -0.27, -0.24, and, -0.29, p < 0.05, respectively), after adjustment for confounders. Changes in job demands were positively associated with changes in somatic symptoms (standardized ß = 0.21, p < 0.05). Significant interactions of changes in testosterone levels and job demands were noted for changes in psychological symptoms (standardized ß = 0.26, p < 0.05). For men with a 1-SD reduction in job demands, negative associations between changes in testosterone levels and psychological symptoms were intensified, but not for men with a 1-SD increase in job demands. CONCLUSION: Andropause symptoms may be affected by changes in testosterone levels and job demands. Change in job demands may modify associations between changes in testosterone levels and andropause symptoms.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Andropausa/fisiologia
Testosterona/sangue
[Mh] Termos MeSH secundário: Adulto
Idoso
Seguimentos
Seres Humanos
Estudos Longitudinais
Masculino
Meia-Idade
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
3XMK78S47O (Testosterone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151231
[St] Status:MEDLINE
[do] DOI:10.1007/s12529-015-9530-y


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[PMID]:25849625
[Au] Autor:Roaiah MF; El Khayat YI; GamalEl Din SF; Abd El Salam MA
[Ad] Endereço:a Sexology & STDs Department, Faculty of Medicine, Cairo University , Cairo , Egypt.
[Ti] Título:Pilot Study on the Effect of Botanical Medicine (Tribulus terrestris) on Serum Testosterone Level and Erectile Function in Aging Males With Partial Androgen Deficiency (PADAM).
[So] Source:J Sex Marital Ther;42(4):297-301, 2016 May 18.
[Is] ISSN:1521-0715
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study was conducted on 30 consecutive male patients presenting to Kasr-Al Ainy Andrology outpatient clinic complaining of manifestations of partial androgen deficiency in aging males (PADAM). In this study (750 mg/day) of Tribulus terrestris in 3 divided doses, each of 250 mg, as an endogenous testosterone enhancer had been tried for a duration of 3 months and the evaluation of its effect had been monitored for each patient concerning its effect on serum testosterone (total and free) and luteinizing hormone (LH), as well as its impact on erectile function, which was evaluated by the International Index of Erectile Function-5 (IIEF-5) questionnaire for those patients. Results showed a statistically significant difference in the level of testosterone (total and free) and IIEF-5, but no statistically significant difference in the level of LH before and after treatment. Also, the study showed statistically significant correlation between testosterone (total and free) and IIEF-5, but no statistically significant correlation between the level of LH and the IIEF-5 before and after treatment.
[Mh] Termos MeSH primário: Disfunção Erétil/tratamento farmacológico
Ereção Peniana/efeitos dos fármacos
Fitoterapia/métodos
Extratos Vegetais/uso terapêutico
Testosterona/sangue
Tribulus
[Mh] Termos MeSH secundário: Idoso
Andropausa
Egito
Seres Humanos
Masculino
Meia-Idade
Projetos Piloto
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 3XMK78S47O (Testosterone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150408
[St] Status:MEDLINE
[do] DOI:10.1080/0092623X.2015.1033579


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[PMID]:26714360
[Au] Autor:Guth MA
[Ti] Título:Compounded Testosterone Troches TO OPTIMIZE HEALTH AND THE TESTOSTERONE CONTROVERSY.
[So] Source:Int J Pharm Compd;19(3):195-203, 2015 May-Jun.
[Is] ISSN:1092-4221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:As men age, testosterone levels progressively fall and inflammatory biomarkers increase. The gradual decline in testosterone production with aging, known as andropause, is common and may have deleterious effects on men including decreased overall well-being, increased sarcopenia, increased risk of cardiovascular disease, reduced sexual function, and bone loss. Therefore, it comes as no surprise that an increasing number of men worldwide have begun requesting testosterone replacement therapy from their physicians. Occasionally, physicians discourage male patients from getting testosterone replacement therapy based on a few recent studies indicating the therapy causes cardiovascular events, including myocardial infarctions. Yet, an extensive review of the testosterone replacement therapy literature reveals that the majority of clinical studies show that properly administered testosterone replacement therapy, in which estradiol and dihydrotestosterone levels are also controlled, has no adverse effects on myocardial infarction risk. The current state-of-the-art in testosterone replacement therapy comprises compounded testosterone troches; an aromatase inhibitor, such as generic Anastrazole, to control estradiol levels; and a 5α-reductase inhibitor, such as beneric Dutasteride or Finasteride, to control dihydrotestosterone. Compounded testosterone troches easily raise serum testosterone levels to the optimal range, are highly cost effective at $82 for a 180-day supply, and provide affordable access to testosterone replacement therapy to millions of men requesting it. Yet, the Blue Cross Blue Shield-associated firms have largely denied requests for coverage of compounded medications, including testosterone troches. Despite data demonstrating strong links between testosterone deficiency and significant comorbid conditions (including Type 2 diabetes and other metabolic syndrome diseases) as well as the health benefits of testosterone replacement therapy, some physian have been swayed against prescribing testosterone replacement therapy to their aging male patients. The testosterone controversy stems largely from poorly designed clinical studies in which patients were subjected to testosterone replacement therapy without having their estradiol and dihydrotestosterone levels properly controlled.
[Mh] Termos MeSH primário: Envelhecimento/sangue
Andropausa
Terapia de Reposição Hormonal/métodos
Testosterona/administração & dosagem
[Mh] Termos MeSH secundário: Inibidores de 5-alfa Redutase/administração & dosagem
Fatores Etários
Inibidores da Aromatase/administração & dosagem
Planos de Seguro Blue Cross Blue Shield
Química Farmacêutica
Formas de Dosagem
Combinação de Medicamentos
Composição de Medicamentos
Custos de Medicamentos
Terapia de Reposição Hormonal/efeitos adversos
Terapia de Reposição Hormonal/economia
Seres Humanos
Reembolso de Seguro de Saúde
Masculino
Segurança do Paciente
Fatores de Risco
Tecnologia Farmacêutica/métodos
Testosterona/efeitos adversos
Testosterona/sangue
Testosterona/química
Testosterona/deficiência
Testosterona/economia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (5-alpha Reductase Inhibitors); 0 (Aromatase Inhibitors); 0 (Dosage Forms); 0 (Drug Combinations); 3XMK78S47O (Testosterone)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:151230
[Lr] Data última revisão:
151230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151231
[St] Status:MEDLINE



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