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[PMID]:29335818
[Au] Autor:Ohrnberger SA; Brinkmann K; Palme R; Valencak TG
[Ad] Endereço:Institute of Physiology, Pathophysiology and Biophysics, Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210, Vienna, Austria. sarah.ohrnberger@vetmeduni.ac.at.
[Ti] Título:Dorsal shaving affects concentrations of faecal cortisol metabolites in lactating golden hamsters.
[So] Source:Naturwissenschaften;105(1-2):13, 2018 Jan 15.
[Is] ISSN:1432-1904
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Breeding of golden hamsters is classically performed at thermal conditions ranging from 20 to 24 °C. However, growing evidence suggests that lactating females suffer from heat stress. We hypothesised that shaving females dorsally to maximise heat dissipation may reduce stress during reproduction. We thus compared faecal cortisol metabolites (FCM) from shaved golden hamster mothers with those from unshaved controls. We observed significantly lower FCM levels in the shaved mothers (F = 8.69, p = 0.0075) pointing to lower stress due to ameliorated heat dissipation over the body surface. In addition, we observed 0.4 °C lower mean subcutaneous body temperatures in the shaved females, although this effect did not reach significance (F = 1.86, p = 0.18). Our results suggest that golden hamsters having body masses being more than four times that of laboratory mice provide a very interesting model to study aspects of lactation and heat production at the same time.
[Mh] Termos MeSH primário: Regulação da Temperatura Corporal
Cricetinae/fisiologia
[Mh] Termos MeSH secundário: Animais
Animais Domésticos
Temperatura Corporal/fisiologia
Fezes/química
Feminino
Remoção de Cabelo/veterinária
Hidrocortisona/metabolismo
Lactação
Reprodução/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1007/s00114-017-1536-7


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[PMID]:28460556
[Au] Autor:Perani CV; Langgartner D; Uschold-Schmidt N; Füchsl AM; Neumann ID; Reber SO; Slattery DA
[Ad] Endereço:a Department of Behavioural and Molecular Neurobiology , University of Regensburg , Regensburg , Germany.
[Ti] Título:Adrenal gland plasticity in lactating rats and mice is sufficient to maintain basal hypersecretion of corticosterone.
[So] Source:Stress;20(3):303-311, 2017 May.
[Is] ISSN:1607-8888
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Increased basal glucocorticoid secretion and a reduced glucocorticoid response during acute stress, despite only minor changes in the secretion of the major secretagogue adrenocorticotropic hormone (ACTH), have been documented in the peripartum period in several species. We recently showed that the adrenal gland, the site of glucocorticoid synthesis, undergoes substantial postpartum-associated plasticity in the rat at mid-lactation. Here, we asked the question whether adrenal changes already take place around parturition in the rat and in another species, namely the mouse. After demonstrating that several components of the adrenal machinery mediating cholesterol supply for steroidogenesis, including protein levels of hormone-sensitive lipase, low-density lipoprotein receptor (LDLR) and scavenger receptor class-B type-1 (SRB1), are upregulated, while hydroxymethylglutaryl coenzyme A reductase (HMGCR) is downregulated in the lactating rat one day after delivery, as previously observed at mid-lactation, we demonstrated profound changes in the mouse. In detail, protein expression of LDLR, SRB1, HMGCR and adrenal lipid store density were increased in the mouse adrenal one day after parturition as tested via western blot analysis and oil-red lipid staining, respectively. Moreover, using in vitro culture techniques, we observed that isolated adrenal explants from lactating mice secreted higher levels of corticosterone under basal conditions, but showed impaired responsiveness to ACTH, mimicking the in vivo scenario. These results suggest that mechanisms of adaptation in the maternal adrenal after delivery, namely increased cholesterol availability and decreased ACTH sensitivity, are crucial for the basal increase in circulating glucocorticoids and maternal stress hyporesponsiveness that are typical of this period.
[Mh] Termos MeSH primário: Glândulas Suprarrenais/secreção
Corticosterona/secreção
Lactação/metabolismo
[Mh] Termos MeSH secundário: Hormônio Adrenocorticotrópico/metabolismo
Animais
Colesterol/metabolismo
Feminino
Hidroximetilglutaril-CoA Redutases/metabolismo
Camundongos
Fosfoproteínas/metabolismo
Período Pós-Parto/metabolismo
Ratos
Receptores da Corticotropina/metabolismo
Receptores de LDL/metabolismo
Receptores Depuradores Classe B/metabolismo
Esterol Esterase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphoproteins); 0 (Receptors, Corticotropin); 0 (Receptors, LDL); 0 (Scavenger Receptors, Class B); 0 (steroidogenic acute regulatory protein); 9002-60-2 (Adrenocorticotropic Hormone); 97C5T2UQ7J (Cholesterol); EC 1.1.1.- (Hydroxymethylglutaryl CoA Reductases); EC 3.1.1.13 (Sterol Esterase); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1080/10253890.2017.1325462


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[PMID]:29422103
[Au] Autor:Thomsson O; Magnusson U; Bergqvist AS; Eliasson-Selling L; Sjunnesson YCB
[Ad] Endereço:Division of Reproduction, Department of Clinical Sciences, Swedish University of Agricultural Sciences, SLU, P.O. Box 7054, 750 07, Uppsala, Sweden.
[Ti] Título:Sow performance in multi-suckling pens with different management routines.
[So] Source:Acta Vet Scand;60(1):10, 2018 Feb 08.
[Is] ISSN:1751-0147
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Production systems with group housing of sows during a part of the lactation are used in certified organic production and can increase the occurrence of lactational estrus thus making batch-wise breeding difficult. The aim of this study was to investigate the occurrence of lactational estrus and time at return to estrus after weaning by following the performance of the sow (change in body weight, back fat and litter size) in three different management routines. The sows and their litters were moved from individual to multi-suckling pen at one (W1; n = 14), two (W2; n = 13), or 3 weeks (W3; n = 16) post farrowing. All sows had a total lactation of 6 weeks. Ovulation was monitored by analysis of fecal progesterone metabolites. Only one sow (W3) ovulated during lactation. Sows in the W2 and W3 groups had a shorter weaning-to-standing estrus interval than W1-sows (2.6 ± 0.3; 2.7 ± 0.2 and 4.0 ± 0.3 days respectively, P < 0.001). The W1-sows and piglets might have kept their nursing bond more intact all through the group housing since the piglets were completely dependent on the nursing at the time of their move to the group pen, thereby staying in lactational anestrus and retaining standard weaning-estrous interval. There was no difference in litter size at grouping or at weaning between management routines and parities. Third and later parity sows had significantly thicker back fat at farrowing and at weaning than 1st and 2nd parity sows (P < 0.05). In conclusion, the occurrence of lactational estrus can be low in a multi-suckling pen and the interval between farrowing and move to a multi-suckling pen can affect the weaning to estrus interval. The short weaning-to-standing estrus interval seen in W2 and W3 suggests that estrus detection should start immediately post weaning for sows kept in multi-suckling pens.
[Mh] Termos MeSH primário: Criação de Animais Domésticos/métodos
Estro/fisiologia
Lactação/fisiologia
Suínos/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Abrigo para Animais/normas
Tamanho da Ninhada de Vivíparos
Desmame
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE
[do] DOI:10.1186/s13028-018-0364-x


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[PMID]:29325588
[Au] Autor:Nørstebø H; Rachah A; Dalen G; Rønningen O; Whist AC; Reksen O
[Ad] Endereço:Department of Production Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, PO Box 8146 Dep, 0033, Oslo, Norway. havard.norstebo@nmbu.no.
[Ti] Título:Milk-flow data collected routinely in an automatic milking system: an alternative to milking-time testing in the management of teat-end condition?
[So] Source:Acta Vet Scand;60(1):2, 2018 Jan 11.
[Is] ISSN:1751-0147
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Having a poor teat-end condition is associated with increased mastitis risk, hence avoiding milking machine settings that have a negative effect on teat-end condition is important for successful dairy production. Milking-time testing (MTT) can be used in the evaluation of vacuum conditions during milking, but the method is less suited for herds using automatic milking systems (AMS) and relationships with teat end condition is poorly described. This study aimed to increase knowledge on interpretation of MTT in AMS and to assess whether milk-flow data obtained routinely by an AMS can be useful for the management of teat-end health. A cross-sectional study, including 251 teats of 79 Norwegian Red cows milked by AMS was performed in the research herd of the Norwegian University of Life Sciences. The following MTT variables were obtained at teat level: Average vacuum level in the short milk tube during main milking (MTVAC), average vacuum in the mouthpiece chamber during main milking and overmilking, teat compression intensity (COMPR) and overmilking time. Average and peak milk flow rates were obtained at quarter level from the AMS software. Teat-end callosity thickness and roughness was registered, and teat dimensions; length, and width at apex and base, were measured. Interrelationships among variables obtained by MTT, quarter milk flow variables, and teat dimensions were described. Associations between these variables and teat-end callosity thickness and roughness, were investigated. RESULTS: Principal component analysis showed clusters of strongly related variables. There was a strong negative relationship between MTVAC and average milk flow rate. The variables MTVAC, COMPR and average and peak milk flow rate were associated with both thickness and roughness of the callosity ring. CONCLUSIONS: Quarter milk flow rate obtained directly from the AMS software was useful in assessing associations between milking machine function and teat-end condition; low average milk flow rates were associated with a higher likelihood of the teat having a thickened or roughened teat-end callosity ring. Since information on milk flow rate is readily available from the herd management system, this information might be used when evaluating causes for impaired teat-end condition in AMS.
[Mh] Termos MeSH primário: Calosidades/prevenção & controle
Indústria de Laticínios/métodos
Lactação/fisiologia
Glândulas Mamárias Animais/patologia
[Mh] Termos MeSH secundário: Animais
Calosidades/etiologia
Calosidades/patologia
Bovinos
Estudos Transversais
Indústria de Laticínios/instrumentação
Feminino
Análise de Componente Principal
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1186/s13028-018-0356-x


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[PMID]:29351973
[Au] Autor:Volkmann N; Kemper N
[Ad] Endereço:Institute for Animal Hygiene, Animal Welfare and Farm Animal Behaviour (ITTN), University of Veterinary Medicine Hannover, Foundation, Germany.
[Ti] Título:Claw condition and claw health in dairy cows: how important is access to pasture?
[So] Source:Vet Rec;182(3):76-78, 2018 01 20.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Casco e Garras
Coxeadura Animal
[Mh] Termos MeSH secundário: Animais
Bovinos
Doenças dos Bovinos
Indústria de Laticínios
Feminino
Doenças do Pé/veterinária
Lactação
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180121
[St] Status:MEDLINE
[do] DOI:10.1136/vr.k193


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[PMID]:29186387
[Au] Autor:Ros P; Díaz F; Freire-Regatillo A; Argente-Arizón P; Barrios V; Argente J; Chowen JA
[Ad] Endereço:Hospital Universitario Puerto de Hierro-Majadahonda, Madrid, Spain.
[Ti] Título:Resveratrol Intake During Pregnancy and Lactation Modulates the Early Metabolic Effects of Maternal Nutrition Differently in Male and Female Offspring.
[So] Source:Endocrinology;159(2):810-825, 2018 02 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Poor maternal nutrition can have detrimental long-term consequences on energy homeostasis in the offspring. Resveratrol exerts antioxidant and antiobesity actions, but its impact during development remains largely unknown. We hypothesized that resveratrol intake during pregnancy and lactation could improve the effects of poor maternal nutrition on offspring metabolism. Wistar rats received a low-fat diet (LFD; 10.2% kcal from fat) or high-fat diet (HFD; 61.6% kcal from fat), with half of each group receiving resveratrol in their drinking water (50 mg/L) during pregnancy and lactation. Body weight (BW) of dams was measured at treatment onset and weaning [postnatal day (PND) 21] and of pups at birth and PND21, at which time dams and pups were euthanized. Although HFD dams consumed more energy, their BW at the end of lactation was unaffected. Mean litter size was not modified by maternal diet or resveratrol. At birth, male offspring from HFD and resveratrol (HFD + R) dams weighed less than those from LFD and resveratrol (LFD + R) dams. On PND21, pups of both sexes from HFD dams weighed more, had more visceral adipose tissue (VAT) and subcutaneous adipose tissue (SCAT), and had higher serum leptin levels than those from LFD dams. Resveratrol reduced BW, leptin, VAT, and SCAT, with females being more affected, but increased glycemia. Neuropeptide levels were unaffected by resveratrol. In conclusion, resveratrol intake during pregnancy and lactation decreased BW and adipose tissue content in offspring of dams on an HFD but did not affect offspring from LFD-fed dams, suggesting that the potential protective effects of resveratrol during gestation/lactation are diet dependent.
[Mh] Termos MeSH primário: Lactação/efeitos dos fármacos
Fenômenos Fisiológicos da Nutrição Materna
Efeitos Tardios da Exposição Pré-Natal/metabolismo
Estilbenos/farmacologia
[Mh] Termos MeSH secundário: Fenômenos Fisiológicos da Nutrição Animal/efeitos dos fármacos
Animais
Ingestão de Alimentos/fisiologia
Feminino
Lactação/metabolismo
Masculino
Fenômenos Fisiológicos da Nutrição Materna/efeitos dos fármacos
Gravidez
Ratos
Ratos Wistar
Caracteres Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Stilbenes); Q369O8926L (resveratrol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00610


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[PMID]:29247653
[Au] Autor:Nishigawa T; Nagamachi S; Chowdhury VS; Yasuo S; Furuse M
[Ad] Endereço:Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
[Ti] Título:Taurine and ß-alanine intraperitoneal injection in lactating mice modifies the growth and behavior of offspring.
[So] Source:Biochem Biophys Res Commun;495(2):2024-2029, 2018 01 08.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Taurine, one of the sulfur-containing amino acids, has several functions in vivo. It has been reported that taurine acts on γ-aminobutyric acid receptors as an agonist and to promote inhibitory neurotransmission. Milk, especially colostrum, contains taurine and it is known that milk taurine is essential for the normal development of offspring. ß-Alanine is transported via a taurine transporter and a protein-assisted amino acid transporter, the same ones that transport taurine. The present study aimed to investigate whether the growth and behavior of offspring could be altered by modification of the taurine concentration in milk. Pregnant ICR mice were separated into 3 groups: 1) a control group, 2) a taurine group, and 3) a ß-alanine group. During the lactation periods, dams were administered, respectively, with 0.9% saline (10 ml/kg, i.p.), taurine dissolved in 0.9% saline (43 mg/10 ml/kg, i.p.), or ß-alanine dissolved in 0.9% saline (31 mg/10 ml/kg, i.p.). Interestingly, the taurine concentration in milk was significantly decreased by the administration of ß-alanine, but not altered by the taurine treatment. The body weight of offspring was significantly lower in the ß-alanine group. ß-Alanine treatment caused a significant decline in taurine concentration in the brains of offspring, and it was negatively correlated with total distance traveled in the open field test at postnatal day 15. Thus, decreased taurine concentration in the brain induced hyperactivity in offspring. These results suggested that milk taurine may have important role of regulating the growth and behavior of offspring.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos dos fármacos
Peso Corporal/efeitos dos fármacos
Lactação/fisiologia
Troca Materno-Fetal/fisiologia
Taurina/administração & dosagem
beta-Alanina/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/fisiologia
Peso Corporal/fisiologia
Relação Dose-Resposta a Droga
Feminino
Injeções Intraperitoneais
Camundongos
Camundongos Endogâmicos ICR
Leite/química
Gravidez
Taurina/química
Resultado do Tratamento
beta-Alanina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
11P2JDE17B (beta-Alanine); 1EQV5MLY3D (Taurine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


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[PMID]:29191934
[Au] Autor:Anand G; Beuschlein F
[Ad] Endereço:Klinik für EndokrinologieDiabetologie und Klinische Ernährung, UniversitätsSpital Zürich, Zürich, Switzerland.
[Ti] Título:MANAGEMENT OF ENDOCRINE DISEASE: Fertility, pregnancy and lactation in women with adrenal insufficiency.
[So] Source:Eur J Endocrinol;178(2):R45-R53, 2018 Feb.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:With the introduction of hormonal substitution therapy in the 1950s, adrenal insufficiency (AI) has been turned into a manageable disease in pregnant women. In fact, in the light of glucocorticoid replacement therapy and improved obstetric care, it is realistic to expect good maternal and fetal outcomes in patients with AI. However, there are still a number of challenges such as establishing the diagnosis of AI in pregnant women and optimizing the treatment of AI and related comorbidities prior to as well as during pregnancy. Clinical and biochemical diagnoses of a new-onset AI may be challenging because of overlapping symptoms of normal pregnancy as well as pregnancy-induced changes in cortisol values. Physiological changes occurring during pregnancy should be taken into account while adjusting the substitution therapy. The high proportion of reported adrenal crisis in pregnant women with AI highlights persistent problems in this particular clinical situation. Due to the rarity of the disease, there is no prospective data-guiding management of pregnancy in patients with known AI. The aim of this review is to summarize the maternal and fetal outcomes based on recently published case reports in patients with AI and to suggest a practical approach to diagnose and manage AI in pregnancy.
[Mh] Termos MeSH primário: Insuficiência Adrenal/fisiopatologia
Insuficiência Adrenal/terapia
Fertilidade/fisiologia
Lactação/fisiologia
Complicações na Gravidez/terapia
[Mh] Termos MeSH secundário: Insuficiência Adrenal/complicações
Insuficiência Adrenal/diagnóstico
Feminino
Seres Humanos
Gravidez
Complicações na Gravidez/diagnóstico
Complicações na Gravidez/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0975


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[PMID]:29281677
[Au] Autor:Mobuchon L; Le Guillou S; Marthey S; Laubier J; Laloë D; Bes S; Le Provost F; Leroux C
[Ad] Endereço:GABI, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.
[Ti] Título:Sunflower oil supplementation affects the expression of miR-20a-5p and miR-142-5p in the lactating bovine mammary gland.
[So] Source:PLoS One;12(12):e0185511, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Oil supplementation in dairy cattle diets is used to modulate milk fat composition, as well as the expression of mammary lipogenic genes, whose regulation remains unclear. MiRNAs are small non-coding RNA considered as crucial regulators of gene expression, offering clues to explain the mechanism underlying gene nutriregulation. The present study was designed to identify miRNAs whose expression in the cow mammary gland is modulated by sunflower oil supplementation. MiRNomes were obtained using RNAseq technology from the mammary gland of lactating cows receiving a low forage diet, supplemented or not with 4% sunflower oil. Among the 272 miRNAs characterized, eight were selected for RT-qPCR validations, showing the significant down-regulation of miR-142-5p and miR-20a-5p by sunflower supplementation. These two miRNAs are predicted to target genes whose expression was reported as differentially expressed by sunflower supplementation. Among their putative targets, ELOVL6 gene involved in lipid metabolism has been studied. However, a first analysis did not show its significant down-regulation, in response to the over-expression of miR-142-5p, of miR-20a-5p, or both, in a bovine mammary epithelial cell line. However, a clearer understanding of the miRNA expression by lipid supplementation would help to decipher the regulation of lactating cow mammary gland in response to nutrition.
[Mh] Termos MeSH primário: Lactação
Glândulas Mamárias Animais/metabolismo
MicroRNAs/genética
Óleo de Girassol/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Bovinos
Feminino
Metabolismo dos Lipídeos/genética
Reação em Cadeia da Polimerase em Tempo Real
Reação em Cadeia da Polimerase Via Transcriptase Reversa
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (MicroRNAs); 0 (Sunflower Oil)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185511


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[PMID]:28747348
[Au] Autor:Ghosh MK; Muller HK; Walker AM
[Ad] Endereço:Division of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA 92521; and.
[Ti] Título:Lactation-Based Maternal Educational Immunity Crosses MHC Class I Barriers and Can Impart Th1 Immunity to Th2-Biased Recipients.
[So] Source:J Immunol;199(5):1729-1736, 2017 09 01.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We have previously demonstrated lactational transfer of T cell-based immunity from dam to foster pup. In the short term, a significant part of transferred immunity is passive cellular immunity. However, as time progresses, this is replaced by what we have described as maternal educational immunity such that by young adulthood, all immune cells responding to a foster dam immunogen are the product of the foster pup's thymus. To reduce confounding factors, this original demonstration used congenic/syngeneic dam and foster pup pairs. In this study, we investigated lactational transfer of immunity to in MHC class I-mismatched animals, as well as from Th1-biased dams to Th2-biased foster pups. Using immunized C57BL/6J dams, lactational transfer to nonimmunized BALB/cJ foster pups resulted in much greater immunity than direct immunization in 5-wk-old pups (ex vivo assay of pup splenocytes). At this age, 82% of immunogen-responding cells in the pup spleen were produced through maternal educational immunity. FVB/NJ nonimmunized foster recipients had a greater number of maternal cells in the spleen and thymus but a much larger percentage was Foxp3 , resulting in equivalent immunity to direct immunization. Depletion of maternal Foxp3 cells from pup splenocytes illustrated a substantial role for lactationally transferred dam regulatory T cells in suppression of the ex vivo response in FVB/NJ, but not BALB/cJ, recipients. We conclude that lactational transfer of immunity can cross MHC class I barriers and that Th1 immunity can be imparted to Th2-biased offspring; in some instances, it can be greater than that achieved by direct immunization.
[Mh] Termos MeSH primário: Imunidade Materno-Adquirida
Lactação/imunologia
Mycobacterium tuberculosis/imunologia
Linfócitos T Reguladores/imunologia
Células Th1/imunologia
Células Th2/imunologia
Timócitos/imunologia
Tuberculose/imunologia
[Mh] Termos MeSH secundário: Animais
Feminino
Fatores de Transcrição Forkhead/metabolismo
Antígenos de Histocompatibilidade Classe I/imunologia
Isoantígenos/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
Gravidez
Equilíbrio Th1-Th2
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Forkhead Transcription Factors); 0 (Foxp3 protein, mouse); 0 (Histocompatibility Antigens Class I); 0 (Isoantigens)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180128
[Lr] Data última revisão:
180128
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1601375



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