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Pesquisa : G08.686.530 [Categoria DeCS]
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[PMID]:29422103
[Au] Autor:Thomsson O; Magnusson U; Bergqvist AS; Eliasson-Selling L; Sjunnesson YCB
[Ad] Endereço:Division of Reproduction, Department of Clinical Sciences, Swedish University of Agricultural Sciences, SLU, P.O. Box 7054, 750 07, Uppsala, Sweden.
[Ti] Título:Sow performance in multi-suckling pens with different management routines.
[So] Source:Acta Vet Scand;60(1):10, 2018 Feb 08.
[Is] ISSN:1751-0147
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Production systems with group housing of sows during a part of the lactation are used in certified organic production and can increase the occurrence of lactational estrus thus making batch-wise breeding difficult. The aim of this study was to investigate the occurrence of lactational estrus and time at return to estrus after weaning by following the performance of the sow (change in body weight, back fat and litter size) in three different management routines. The sows and their litters were moved from individual to multi-suckling pen at one (W1; n = 14), two (W2; n = 13), or 3 weeks (W3; n = 16) post farrowing. All sows had a total lactation of 6 weeks. Ovulation was monitored by analysis of fecal progesterone metabolites. Only one sow (W3) ovulated during lactation. Sows in the W2 and W3 groups had a shorter weaning-to-standing estrus interval than W1-sows (2.6 ± 0.3; 2.7 ± 0.2 and 4.0 ± 0.3 days respectively, P < 0.001). The W1-sows and piglets might have kept their nursing bond more intact all through the group housing since the piglets were completely dependent on the nursing at the time of their move to the group pen, thereby staying in lactational anestrus and retaining standard weaning-estrous interval. There was no difference in litter size at grouping or at weaning between management routines and parities. Third and later parity sows had significantly thicker back fat at farrowing and at weaning than 1st and 2nd parity sows (P < 0.05). In conclusion, the occurrence of lactational estrus can be low in a multi-suckling pen and the interval between farrowing and move to a multi-suckling pen can affect the weaning to estrus interval. The short weaning-to-standing estrus interval seen in W2 and W3 suggests that estrus detection should start immediately post weaning for sows kept in multi-suckling pens.
[Mh] Termos MeSH primário: Criação de Animais Domésticos/métodos
Estro/fisiologia
Lactação/fisiologia
Suínos/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Abrigo para Animais/normas
Tamanho da Ninhada de Vivíparos
Desmame
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE
[do] DOI:10.1186/s13028-018-0364-x


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[PMID]:29178316
[Au] Autor:Putz AM; Tiezzi F; Maltecca C; Gray KA; Knauer MT
[Ad] Endereço:Department of Animal Science, North Carolina State University, Raleigh, NC, USA.
[Ti] Título:A comparison of accuracy validation methods for genomic and pedigree-based predictions of swine litter size traits using Large White and simulated data.
[So] Source:J Anim Breed Genet;135(1):5-13, 2018 Feb.
[Is] ISSN:1439-0388
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to compare and determine the optimal validation method when comparing accuracy from single-step GBLUP (ssGBLUP) to traditional pedigree-based BLUP. Field data included six litter size traits. Simulated data included ten replicates designed to mimic the field data in order to determine the method that was closest to the true accuracy. Data were split into training and validation sets. The methods used were as follows: (i) theoretical accuracy derived from the prediction error variance (PEV) of the direct inverse (iLHS), (ii) approximated accuracies from the accf90(GS) program in the BLUPF90 family of programs (Approx), (iii) correlation between predictions and the single-step GEBVs from the full data set (GEBV ), (iv) correlation between predictions and the corrected phenotypes of females from the full data set (Y ), (v) correlation from method iv divided by the square root of the heritability (Y ) and (vi) correlation between sire predictions and the average of their daughters' corrected phenotypes (Y ). Accuracies from iLHS increased from 0.27 to 0.37 (37%) in the Large White. Approximation accuracies were very consistent and close in absolute value (0.41 to 0.43). Both iLHS and Approx were much less variable than the corrected phenotype methods (ranging from 0.04 to 0.27). On average, simulated data showed an increase in accuracy from 0.34 to 0.44 (29%) using ssGBLUP. Both iLHS and Y approximated the increase well, 0.30 to 0.46 and 0.36 to 0.45, respectively. GEBV performed poorly in both data sets and is not recommended. Results suggest that for within-breed selection, theoretical accuracy using PEV was consistent and accurate. When direct inversion is infeasible to get the PEV, correlating predictions to the corrected phenotypes divided by the square root of heritability is adequate given a large enough validation data set.
[Mh] Termos MeSH primário: Cruzamento
Genômica
Tamanho da Ninhada de Vivíparos/genética
Modelos Estatísticos
Linhagem
Suínos/genética
Suínos/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1111/jbg.12302


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[PMID]:29208414
[Au] Autor:Zhang RQ; Lai FN; Wang JJ; Zhai HL; Zhao Y; Sun YJ; Min LJ; Shen W
[Ad] Endereço:College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China.
[Ti] Título:Analysis of the SNP loci around transcription start sites related to goat fecundity trait base on whole genome resequencing.
[So] Source:Gene;643:1-6, 2018 Feb 15.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Genome flanking regions surrounding transcription start sites (TSSs) are critical for the regulation of gene expression, containing many translational regulatory elements. To investigate whether critical single nucleotide polymorphisms (SNPs) exist around TSSs in the dairy goat genome, we performed high throughput DNA sequencing to compare two dairy goat groups with discrepant litter sizes. After genome mapping, SNP calling, and annotation, we screened the SNPs within 2kb scales surrounding annotated TSSs in high fecundity (HF) and low fecundity (LF) groups, respectively. We attempted to identify distinct SNPs and motifs near the TSSs in both groups. The SNPs near the TSSs most were consistent; 318 new SNPs were uncovered in the HF group, of which 305 were heterozygote SNPs, 13 were homozygote SNPs, and majority of which were distributed on chromosome 2 and 29. After validation by Sanger sequencing we found that a SNP in CHI16: 27612330 C>A in the PSEN2 gene presented an A/A genotype in the HF group and an A/A or A/C genotype in the LF group. In conclusion, our study provides insightful information into the dairy goat genomic variations surrounding TSSs, which may contribute to enhanced litter size. Based on comparison studies of SNPs exist around transcription start sites between high fecundity group and low fecundity group. Our finding provides insights concerning the goat litter size phenotypic and will promote future goat breeding.
[Mh] Termos MeSH primário: Fertilidade/genética
Cabras/genética
Tamanho da Ninhada de Vivíparos/genética
[Mh] Termos MeSH secundário: Animais
Cruzamento
Mapeamento Cromossômico/métodos
Feminino
Genótipo
Sequenciamento de Nucleotídeos em Larga Escala/métodos
Fenótipo
Polimorfismo de Nucleotídeo Único/genética
Gravidez
Regiões Promotoras Genéticas/genética
Análise de Sequência de DNA/métodos
Sítio de Iniciação de Transcrição/fisiologia
Ativação Transcricional/genética
Sequenciamento Completo do Genoma/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


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[PMID]:29206840
[Au] Autor:Campbell RD; Rosell F; Newman C; Macdonald DW
[Ad] Endereço:University College of Southeast Norway, Department of Natural Sciences and Environmental Health, Bø i Telemark, Norway.
[Ti] Título:Age-related changes in somatic condition and reproduction in the Eurasian beaver: Resource history influences onset of reproductive senescence.
[So] Source:PLoS One;12(12):e0187484, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Using 15 years of data from a stable population of wild Eurasian beavers (Castor fiber), we examine how annual and lifetime access to food resources affect individual age-related changes in reproduction and somatic condition. We found an age-related decline in annual maternal reproductive output, after a peak at age 5-6. Rainfall, an established negative proxy of annual resource availability for beavers, was consistently associated with lower reproductive output for females of all ages. In contrast, breeding territory quality, as a measure of local resource history over reproductive lifetimes, caused differences in individual patterns of reproductive senescence; animals from lower quality territories senesced when younger. Litter size was unrelated to maternal age, although adult body weight increased with age. In terms of resource effects, in poorer years but not in better years, older mothers produced larger offspring than did younger mothers, giving support to the constraint theory. Overall, our findings exemplify state-dependent life-history strategies, supporting an effect of resources on reproductive senescence, where cumulative differences in resource access, and not just reproductive strategy, mediate long-term reproductive trade-offs, consistent with the disposable soma and reproductive restraint theories. We propose that flexible life-history schedules could play a role in the dynamics of populations exhibiting reproductive skew, with earlier breeding opportunities leading to an earlier senescence schedule through resource dependent mechanisms.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Roedores/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Tamanho da Ninhada de Vivíparos
Masculino
Gravidez
Reprodução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0187484


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[PMID]:29032151
[Au] Autor:Mandal K; Sarkar RK; Sen Sharma S; Jain A; Majumdar SS
[Ad] Endereço:Cellular Endocrinology Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India. Electronic address: kamal_mandal@nii.ac.in.
[Ti] Título:Sertoli cell specific knockdown of RAR-related orphan receptor (ROR) alpha at puberty reduces sperm count in rats.
[So] Source:Gene;641:18-24, 2018 Jan 30.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Globally, there is an alarming decline in sperm count. Very often hormonal supplementation fails to restore normal sperm count. Sertoli cells (Sc) present within seminiferous tubules provide appropriate niche and factors required for the differentiation of germ cells (Gc) into mature sperm (spermatogenesis). Functionally compromised Sc may be one of the reasons for failure of hormones to facilitate normal spermatogenesis. Although role of secretory proteins and signaling molecules of Sc has been studied well, role of transcription factors regulating sperm count has not been addressed appropriately. Retinoic acid receptor-related orphan receptor (ROR)-alpha is one of such transcription factors reported in testis but its role in testicular function is not yet known. In a separate study, we found abundant ROR-alpha binding sites on promoter regions of several genes upregulated in pubertal rat Sc as compared to infant Sc. Immunostaining studies also revealed presence of ROR alpha in nucleus of pubertal Sc. We generated a transgenic knockdown rat model expressing shRNA targeted to ROR-alpha under Sc specific promoter, which is transcriptionally active only at and after puberty. ROR-alpha knockdown animals were found to have abnormal association of Sc and Gc, including Gc sloughing and restricted release of sperm. The knockdown animals displayed compromised spermatogenesis leading to significant reduction in sperm count. This is the first report describing the Sc specific role of ROR-alpha in maintaining quantitatively normal sperm output. Identification of various such molecules can generate avenues to limit or reverse an alarmingly declining sperm count witnessed globally in men.
[Mh] Termos MeSH primário: Membro 1 do Grupo F da Subfamília 1 de Receptores Nucleares/biossíntese
Membro 1 do Grupo F da Subfamília 1 de Receptores Nucleares/genética
Células de Sertoli/metabolismo
Contagem de Espermatozoides
Espermatogênese/fisiologia
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Infertilidade Masculina/genética
Tamanho da Ninhada de Vivíparos/genética
Masculino
Interferência de RNA
RNA Interferente Pequeno/genética
Ratos
Ratos Transgênicos
Ratos Wistar
Espermatogênese/genética
Testículo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nuclear Receptor Subfamily 1, Group F, Member 1); 0 (RNA, Small Interfering)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171017
[St] Status:MEDLINE


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[PMID]:28880934
[Au] Autor:Hwang JH; An SM; Kwon S; Park DH; Kim TW; Kang DG; Yu GE; Kim IS; Park HC; Ha J; Kim CW
[Ad] Endereço:Swine Science and Technology Center, Gyeongnam National University of Science & Technology, Jinju, South Korea.
[Ti] Título:DNA methylation patterns and gene expression associated with litter size in Berkshire pig placenta.
[So] Source:PLoS One;12(9):e0184539, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Increasing litter size is of great interest to the pig industry. DNA methylation is an important epigenetic modification that regulates gene expression, resulting in livestock phenotypes such as disease resistance, milk production, and reproduction. We classified Berkshire pigs into two groups according to litter size and estimated breeding value: smaller (SLG) and larger (LLG) litter size groups. Genome-wide DNA methylation and gene expression were analyzed using placenta genomic DNA and RNA to identify differentially methylated regions (DMRs) and differentially expressed genes (DEGs) associated with litter size. The methylation levels of CpG dinucleotides in different genomic regions were noticeably different between the groups, while global methylation pattern was similar, and excluding intergenic regions they were found the most frequently in gene body regions. Next, we analyzed RNA-Seq data to identify DEGs between the SLG and LLG groups. A total of 1591 DEGs were identified: 567 were downregulated and 1024 were upregulated in LLG compared to SLG. To identify genes that simultaneously exhibited changes in DNA methylation and mRNA expression, we integrated and analyzed the data from bisulfite-Seq and RNA-Seq. Nine DEGs positioned in DMRs were found. The expression of only three of these genes (PRKG2, CLCA4, and PCK1) was verified by RT-qPCR. Furthermore, we observed the same methylation patterns in blood samples as in the placental tissues by PCR-based methylation analysis. Together, these results provide useful data regarding potential epigenetic markers for selecting hyperprolific sows.
[Mh] Termos MeSH primário: Metilação de DNA/genética
Expressão Gênica/genética
Placenta/metabolismo
[Mh] Termos MeSH secundário: Animais
Ilhas de CpG/genética
Epigênese Genética/genética
Feminino
Perfilação da Expressão Gênica
Tamanho da Ninhada de Vivíparos
Gravidez
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184539


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[PMID]:28719646
[Au] Autor:Chen ZY; Yao Y
[Ad] Endereço:Department of Nutrition, Tongji Hospital, Tongji Medical College, Huazhong University Science and Technology, Wuhan, Hubei, China.
[Ti] Título:A synergistic negative effect of gestational smoke-exposure and small litter size on rat placental efficiency, vascularisation and angiogenic factors mRNA expression.
[So] Source:PLoS One;12(7):e0181348, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Smoking increases the risk of pregnancy complications such as spontaneous abortion and low birth weight (LBW). By cigarette smoke exposure (gestational day, GD3-17), normal-litter-size pregnancy with low birth weight (NP-LBW) and small-litter-size pregnancy with normal birth weight (SP-NBW) in rats were induced. The placental weight in SP-NBW was twice the weight of the normal in contrast with the smaller placenta in NP-LBW. Compared with the normal, placental efficiency (expressed as fetus-to-placenta weight ratio) and placental vascularisation were significantly decreased in smoke exposed placentas with more obvious decrease in SP-NBW. For NP-LBW, decreased placental vascularisation was due to decreased labyrinth vascularisation which was caused by both decreased number density and diameter of fetal capillary. For SP-NBW, decreased placental vascularisation was due to reduced proportion of labyrinth in placenta and decreased labyrinth vascularisation which was caused by decreased fetal capillary number density. Real time RT-PCR analysis showed a tendency for decreased placental mRNA level of vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang1) and tyrosine kinase receptor-2 (Tie2) in NP-LBW(P<0.1), and the tendency became obvious in SP-NBW(P<0.05). A tendency for decreased placental mRNA level of fms-like tyrosine kinase-1(Flt1) and angiopoietin-2 (Ang2) was also observed in SP-LBW(P<0.1). Our data demonstrated the synergistic negative effect of gestational smoke-exposure and small litter size on placental efficiency, placental vascularisation and placental angiogenic growth factor mRNA expression in rat.
[Mh] Termos MeSH primário: Regulação da Expressão Gênica/efeitos dos fármacos
Tamanho da Ninhada de Vivíparos
Neovascularização Fisiológica/efeitos dos fármacos
Placenta/efeitos dos fármacos
Placenta/fisiologia
Fumaça/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Peso ao Nascer/efeitos dos fármacos
Feminino
Tamanho do Órgão/efeitos dos fármacos
Placenta/irrigação sanguínea
Placenta/metabolismo
Gravidez
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Messenger); 0 (Smoke)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181348


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[PMID]:28545153
[Au] Autor:Vazquez-Gomez M; Garcia-Contreras C; Torres-Rovira L; Pesantez JL; Gonzalez-Añover P; Gomez-Fidalgo E; Sanchez-Sanchez R; Ovilo C; Isabel B; Astiz S; Gonzalez-Bulnes A
[Ad] Endereço:Faculty of Veterinary Sciences, UCM, Madrid, Spain.
[Ti] Título:Polyphenols and IUGR pregnancies: Maternal hydroxytyrosol supplementation improves prenatal and early-postnatal growth and metabolism of the offspring.
[So] Source:PLoS One;12(5):e0177593, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hydroxytyrosol is a polyphenol with antioxidant, metabolism-regulatory, anti-inflammatory and immuno-modulatory properties. The present study aimed to determine whether supplementing the maternal diet with hydroxytyrosol during pregnancy can improve pre- and early post-natal developmental patterns and metabolic traits of the offspring. Experiment was performed in Iberian sows fed a restricted diet in order to increase the risk of IUGR. Ten sows were treated daily with 1.5 mg of hydroxytyrosol per kg of feed between Day 35 of pregnancy (30% of total gestational period) until delivery whilst 10 animals were left untreated as controls. Number and weight of offspring were assessed at birth, on post-natal Day 15 and at weaning (25 days-old). At weaning, body composition and plasma indexes of glucose and lipids were measured. Treatment with hydroxytyrosol was associated with higher mean birth weight, lower incidence of piglets with low birth weight. Afterwards, during the lactation period, piglets in the treated group showed a higher body-weight than control piglets; such effects were even stronger in the most prolific litters. These results suggest that maternal supplementation with hydroxytyrosol may improve pre- and early post-natal development of offspring in pregnancies at risk of IUGR.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Peso ao Nascer/efeitos dos fármacos
Composição Corporal/efeitos dos fármacos
Retardo do Crescimento Fetal/patologia
Álcool Feniletílico/análogos & derivados
Polifenóis/farmacologia
[Mh] Termos MeSH secundário: Ração Animal
Fenômenos Fisiológicos da Nutrição Animal
Animais
Glicemia/análise
Suplementos Nutricionais
Feminino
Tamanho da Ninhada de Vivíparos/efeitos dos fármacos
Masculino
Álcool Feniletílico/farmacologia
Cuidado Pós-Natal
Gravidez
Fenômenos Fisiológicos da Nutrição Pré-Natal
Fatores Sexuais
Suínos
Desmame
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Blood Glucose); 0 (Polyphenols); 10597-60-1 (3,4-dihydroxyphenylethanol); ML9LGA7468 (Phenylethyl Alcohol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177593


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[PMID]:28532460
[Au] Autor:Blasco A; Martínez-Álvaro M; García ML; Ibáñez-Escriche N; Argente MJ
[Ad] Endereço:Institute for Animal Science and Technology, Universitat Politècnica de València, Valencia, Spain. ablasco@dca.upv.es.
[Ti] Título:Selection for environmental variance of litter size in rabbits.
[So] Source:Genet Sel Evol;49(1):48, 2017 May 22.
[Is] ISSN:1297-9686
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In recent years, there has been an increasing interest in the genetic determination of environmental variance. In the case of litter size, environmental variance can be related to the capacity of animals to adapt to new environmental conditions, which can improve animal welfare. RESULTS: We developed a ten-generation divergent selection experiment on environmental variance. We selected one line of rabbits for litter size homogeneity and one line for litter size heterogeneity by measuring intra-doe phenotypic variance. We proved that environmental variance of litter size is genetically determined and can be modified by selection. Response to selection was 4.5% of the original environmental variance per generation. Litter size was consistently higher in the Low line than in the High line during the entire experiment. CONCLUSIONS: We conclude that environmental variance of litter size is genetically determined based on the results of our divergent selection experiment. This has implications for animal welfare, since animals that cope better with their environment have better welfare than more sensitive animals. We also conclude that selection for reduced environmental variance of litter size does not depress litter size.
[Mh] Termos MeSH primário: Interação Gene-Ambiente
Tamanho da Ninhada de Vivíparos/genética
Coelhos/genética
Seleção Artificial
[Mh] Termos MeSH secundário: Animais
Ecossistema
Feminino
Variação Genética
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.1186/s12711-017-0323-4


  10 / 5047 MEDLINE  
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[PMID]:28502193
[Au] Autor:Branquinho NTD; Cruz GHP; Borrasca CL; Alves LPS; de Godoy Gomes CR; Ferreira de Godoi VA; Pedrosa MMD
[Ad] Endereço:a Program of Graduate Studies in Biological Sciences , State University of Maringá , Maringa, Brazil.
[Ti] Título:Early-onset obesity and food restriction alter hepatocyte metabolism in adult Wistar rats.
[So] Source:Arch Physiol Biochem;123(5):297-305, 2017 Dec.
[Is] ISSN:1744-4160
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Caloric restriction (CR) is suggested for overweight control. OBJECTIVE: Systemic and liver glucose metabolism in the reduced-litter (RL) rat model under 30% CR was investigated. MATERIALS AND METHODS: Newborn litters were organised in control (G9); RL with free diet (G3L); and RL with CR (G3R). Assessments were made at the age of 90 d. RESULTS: Higher liver glycogen content and changes in systemic glucose handling were found in the RL groups. Hepatocyte glucose metabolism was similar in groups G9 and G3L, but basal glucose production and glycogenolysis were higher, while gluconeogenesis and basal glycolysis were lower in the G3R. Urea production was lower in the RL groups. DISCUSSION: The altered glucose handling of the RL adult rats was not reversed by moderate (30%) CR. Hepatocyte glucose and nitrogen metabolism were changed by both early overfeeding and current feeding conditions. CONCLUSIONS: RL and CR alter systemic and liver glucose metabolism.
[Mh] Termos MeSH primário: Restrição Calórica
Hepatócitos/metabolismo
Obesidade/metabolismo
Obesidade/patologia
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Glicemia/metabolismo
Feminino
Lactação
Tamanho da Ninhada de Vivíparos
Masculino
Obesidade/sangue
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE
[do] DOI:10.1080/13813455.2017.1326942



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