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[PMID]:28458114
[Au] Autor:Liao H; Duan G; Liu P; Liu Y; Pang Y; Liu H; Tang L; Tao J; Wen D; Li S; Liang L; Deng D
[Ad] Endereço:Department of Radiology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi 530023, China.
[Ti] Título:Altered fractional amplitude of low frequency fluctuation in premenstrual syndrome: A resting state fMRI study.
[So] Source:J Affect Disord;218:41-48, 2017 Aug 15.
[Is] ISSN:1573-2517
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Premenstrual syndrome (PMS) is becoming highly prevalent among female and is characterized by emotional, physical and behavior symptoms. Previous evidence suggested functional dysregulation of female brain was expected to be involved in the etiology of PMS. The aim of present study was to evaluate the alterations of spontaneous brain activity in PMS patients based on functional magnetic resonance imaging (fMRI). METHODS: 20 PMS patients and 21 healthy controls underwent resting-state fMRI scanning during luteal phase. All participants were asked to complete a prospective daily record of severity of problems (DRSP) questionnaire. RESULTS: Compared with healthy controls, the results showed that PMS patients had increased fALFF in bilateral precuneus, left hippocampus and left inferior temporal cortex, and decreased fALFF in bilateral anterior cingulate cortex (ACC) and cerebellum at luteal phase. Moreover, the DRSP scores of PMS patients were negatively correlated with the mean fALFF in ACC and positively correlated with the fALFF in precuneus. LIMITATIONS: (1) the study did not investigate whether or not abnormal brain activity differences between groups in mid-follicular phase, and within-group changes. between phases.(2) it was relatively limited sample size and the participants were young; (3) fALFF could not provide us with more holistic information of brain network;(4) the comparisons of PMS and premenstrual dysphoric disorder (PMDD) were not involved in the study. CONCLUSIONS: The present study shows abnormal spontaneous brain activity in PMS patients revealed by fALFF, which could provide neuroimaging evidence to further improve our understanding of the underlying neural mechanism of PMS.
[Mh] Termos MeSH primário: Encéfalo/fisiopatologia
Imagem por Ressonância Magnética/métodos
Síndrome Pré-Menstrual/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Mapeamento Encefálico/métodos
Feminino
Fase Folicular
Giro do Cíngulo/fisiopatologia
Seres Humanos
Fase Luteal
Neuroimagem
Lobo Parietal/fisiopatologia
Transtorno Disfórico Pré-Menstrual/fisiopatologia
Estudos Prospectivos
Lobo Temporal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:28466535
[Au] Autor:Phoophitphong D; Srisuwatanasagul S; Tummaruk P
[Ad] Endereço:Department of Obstetrics, Gynaecology and Reproduction, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, 10330, Thailand.
[Ti] Título:Leptin Immunohistochemical Staining in the Porcine Ovary.
[So] Source:Anat Histol Embryol;46(4):334-341, 2017 Aug.
[Is] ISSN:1439-0264
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:This study aimed to investigate leptin immuno-staining of the porcine ovary in different reproductive stages. Ovaries from 21 gilts were collected from slaughterhouses. The ovarian tissue sections were incubated with a polyclonal anti-leptin as a primary antibody. The immuno-staining in ovarian tissue compartments was calculated using imaging software. Leptin immuno-staining was found in primordial, primary, preantral and antral follicles. Leptin immuno-staining was expressed in the oocyte and granulosa and theca interna layers in both preantral and antral follicles. In the corpora lutea, leptin immuno-staining was found in the cytoplasm of the luteal cells. The leptin immuno-staining in the granulosa cell layer of preantral follicles did not differ compared to antral follicles (90.7 and 91.3%, respectively, P > 0.05). However, the leptin immuno-staining in the theca interna layer of preantral follicles was lower than antral follicles (49.4 and 74.3%, respectively, P < 0.001). There was no difference in leptin immuno-staining in the granulosa cell layer between follicular and luteal phases (92.4 and 89.7%, respectively, P > 0.05). However, the leptin immuno-staining in the theca interna layer of follicular phase was greater than that in the luteal phase (72.7 and 51.0%, respectively, P < 0.001). These findings indicated that leptin exists in different compartments of the porcine ovary, including the oocyte, granulosa cells, theca interna cells, corpus luteum, blood vessel and smooth muscles. Therefore, this morphological study confirmed a close relationship between leptin and ovarian function in the pig.
[Mh] Termos MeSH primário: Leptina/análise
Ovário/química
Suínos/metabolismo
[Mh] Termos MeSH secundário: Proteínas Angiogênicas
Animais
Peso Corporal/fisiologia
Corpo Lúteo/química
Feminino
Fase Folicular
Células da Granulosa/química
Processamento de Imagem Assistida por Computador
Imuno-Histoquímica/veterinária
Fase Luteal
Oócitos/química
Folículo Ovariano/anatomia & histologia
Folículo Ovariano/química
Ovário/metabolismo
Suínos/anatomia & histologia
Células Tecais/química
Ganho de Peso/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AGGF1 protein, human); 0 (Angiogenic Proteins); 0 (Leptin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1111/ahe.12274


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[PMID]:28911135
[Au] Autor:Arnoni-Bauer Y; Bick A; Raz N; Imbar T; Amos S; Agmon O; Marko L; Levin N; Weiss R
[Ad] Endereço:Department of Human Metabolism and Nutrition, Braun School of Public Health, Hebrew University, Jerusalem 91120, Israel.
[Ti] Título:Is It Me or My Hormones? Neuroendocrine Activation Profiles to Visual Food Stimuli Across the Menstrual Cycle.
[So] Source:J Clin Endocrinol Metab;102(9):3406-3414, 2017 Sep 01.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Context: Homeostatic energy balance is controlled via the hypothalamus, whereas regions controlling reward and cognitive decision-making are critical for hedonic eating. Eating varies across the menstrual cycle peaking at the midluteal phase. Objective: To test responses of females with regular cycles during midfollicular and midluteal phase and of users of monophasic oral contraception pills (OCPs) to visual food cues. Design: Participants performed a functional magnetic resonance imaging while exposed to visual food cues in four time points: fasting and fed conditions in midfollicular and midluteal phases. Patients: Twenty females with regular cycles and 12 on monophasic OCP, aged 18 to 35 years. Main Outcome Measures: Activity in homeostatic (hypothalamus), reward (amygdala, putamen and insula), frontal (anterior cingulate cortex, dorsolateral prefrontal cortex), and visual regions (calcarine and lateral occipital cortex). Setting: Tertiary hospital. Results: In females with regular cycles, brain regions associated with homeostasis but also the reward system, executive frontal areas, and afferent visual areas were activated to a greater degree during the luteal compared with the follicular phase. Within the visual areas, a dual effect of hormonal and prandial state was seen. In females on monophasic OCPs, characterized by a permanently elevated progesterone concentration, activity reminiscent of the luteal phase was found. Androgen, cortisol, testosterone, and insulin levels were significantly correlated with reward and visual region activation. Conclusions: Hormonal mechanisms affect the responses of women's homeostatic, emotional, and attentional brain regions to food cues. The relation of these findings to eating behavior throughout the cycle needs further investigation.
[Mh] Termos MeSH primário: Córtex Cerebral/diagnóstico por imagem
Comportamento Alimentar/fisiologia
Imagem por Ressonância Magnética/métodos
Ciclo Menstrual/fisiologia
Sistemas Neurossecretores/fisiologia
Estimulação Luminosa
[Mh] Termos MeSH secundário: Adolescente
Adulto
Tonsila do Cerebelo/fisiologia
Córtex Cerebral/fisiologia
Sinais (Psicologia)
Comportamento Alimentar/psicologia
Feminino
Fase Folicular/fisiologia
Seres Humanos
Hipotálamo/fisiologia
Fase Luteal/fisiologia
Ciclo Menstrual/psicologia
Amostragem
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2016-3921


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[PMID]:28579410
[Au] Autor:Ecochard R; Bouchard T; Leiva R; Abdulla S; Dupuis O; Duterque O; Garmier Billard M; Boehringer H; Genolini C
[Ad] Endereço:Hospices Civils de Lyon, Service de Biostatistique-Bioinformatique, Lyon, France; Université de Lyon, Lyon, France; Université Lyon 1, Villeurbanne, France; CNRS, Laboratoire de Biométrie et Biologie Évolutive, Équipe Biostatistique-Santé, Villeurbanne, France. Electronic address: rene.ecochard@chu-
[Ti] Título:Characterization of hormonal profiles during the luteal phase in regularly menstruating women.
[So] Source:Fertil Steril;108(1):175-182.e1, 2017 Jul.
[Is] ISSN:1556-5653
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To characterize the variability of hormonal profiles during the luteal phase in normal cycles. DESIGN: Observational study. SETTING: Not applicable. PATIENT(S): Ninety-nine women contributing 266 menstrual cycles. INTERVENTION(S): The women collected first morning urine samples that were analyzed for estrone-3-glucuronide, pregnanediol-3-alpha-glucuronide (PDG), FSH, and LH. The women had serum P tests (twice per cycle) and underwent ultrasonography to identify the day of ovulation. MAIN OUTCOME MEASURE(S): The luteal phase was divided into three parts: the early luteal phase with increasing PDG (luteinization), the midluteal phase with PDG ≥10 µg/mg Cr (progestation), and the late luteal phase (luteolysis) when PDG fell below 10 µg/mg Cr. RESULT(S): Long luteal phases begin with long luteinization processes. The early luteal phase is marked by low PDG and high LH levels. Long luteinization phases were correlated with low E1G and low PDG levels at day 3. The length of the early luteal phase is highly variable between cycles of the same woman. The duration and hormonal levels during the rest of the luteal phase were less correlated with other characteristics of the cycle. CONCLUSION(S): The study showed the presence of a prolonged pituitary activity during the luteinization process, which seems to be modulated by an interaction between P and LH. This supports a luteal phase model with three distinct processes: the first is a modulated luteinization process, whereas the second and the third are relatively less modulated processes of progestation and luteolysis.
[Mh] Termos MeSH primário: Hormônios/sangue
Hormônios/urina
Fase Luteal/sangue
Fase Luteal/urina
Menstruação/sangue
Menstruação/urina
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Valores de Referência
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hormones)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE


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[PMID]:28476647
[Au] Autor:Jeon HJ; Cui XS; Guo J; Lee JM; Kim JS; Oh JS
[Ad] Endereço:Department of Genetic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Republic of Korea.
[Ti] Título:TCTP regulates spindle assembly during postovulatory aging and prevents deterioration in mouse oocyte quality.
[So] Source:Biochim Biophys Acta;1864(7):1328-1334, 2017 07.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:If no fertilization occurs for a prolonged time following ovulation, oocytes experience a time-dependent deterioration in quality both in vivo and in vitro due to processes called postovulatory aging. Because the postovulatory aging of oocytes has marked detrimental effects on embryo development and offspring, many efforts have been made to unveil the underlying mechanisms. Here we showed that translationally controlled tumor protein (TCTP) regulates spindle assembly during postovulatory aging and prevents deterioration in mouse oocyte quality. Spindle dynamics decreased with reduced TCTP level during aging of mouse oocytes. Knockdown of TCTP accelerated the reduction of spindle dynamics, accompanying with aging-related deterioration of oocyte quality. Conversely, overexpression of TCTP prevented aging-associated decline of spindle dynamics. Moreover, the aging-related abnormalities in oocytes were rescued after TCTP overexpression, thereby improving fertilization competency and subsequent embryo development. Therefore, our results demonstrate that TCTP-mediated spindle dynamics play a key role in maintaining oocyte quality during postovulatory aging and overexpression of TCTP is sufficient to prevent aging-associated abnormalities in mouse oocytes.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/metabolismo
Senescência Celular
Fase Luteal/metabolismo
Oócitos/metabolismo
Fuso Acromático/metabolismo
[Mh] Termos MeSH secundário: Animais
Biomarcadores Tumorais/genética
Blastocisto/metabolismo
Células Cultivadas
Feminino
Fase Luteal/genética
Masculino
Camundongos
Oócitos/citologia
Oogênese
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (tumor protein, translationally-controlled 1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE


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[PMID]:28397981
[Au] Autor:Helmy MEE; Maher MA; Elkhouly NI; Ramzy M
[Ad] Endereço:Obstetrics and Gynecology Department, Faculty of Medicine, Menoufia University, Shebin-Elkom, Egypt.
[Ti] Título:A randomized trial of local endometrial injury during ovulation induction cycles.
[So] Source:Int J Gynaecol Obstet;138(1):47-52, 2017 Jul.
[Is] ISSN:1879-3479
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate the effect of endometrial injury on pregnancy outcomes among infertile women taking clomifene citrate. METHODS: A prospective randomized trial was undertaken at an Egyptian hospital between January 26, 2015, and July 17, 2016. Eligible women (≥1 year primary/secondary/unexplained infertility, aged 20-35 years, day-2 follicle-stimulating hormone <12 IU/L, normal prolactin/thyroid function/uterine cavity, ≥1 patent tube, male partner with normal semen count and motility, 3 cycles of clomifene citrate without success) were randomly allocated (1:1) using computer-generated numbers into intervention (received endometrial injury on cycle day 15-24) or control groups (sham procedure). Women began ovulation induction on days 3-5 of the following cycle. Participants and investigators were not masked to group assignment. The primary outcomes were clinical pregnancy, spontaneous abortion, and multiple pregnancy rates. Women who completed follow-up were included in analyses. RESULTS: The intervention group included 52 women and the control group 53 women. The clinical pregnancy rate was significantly higher in the intervention group (37% [n=19]) than in the control group (13% [n=7]; P=0.006). No differences between the intervention and control groups were noted for spontaneous abortion rate (11% [2/19] vs 29% [2/7]; P=0.287) or multiple pregnancy rate (11% [2/19] vs 14% [1/7]; P=0.790). No adverse effects were reported. CONCLUSION: Endometrial injury before ovulation induction could improve chances of pregnancy and its outcomes. CLINICALTRIALS.GOV: NCT02345837.
[Mh] Termos MeSH primário: Clomifeno/uso terapêutico
Endométrio/lesões
Fármacos para a Fertilidade Feminina/uso terapêutico
Infertilidade Feminina/terapia
Indução da Ovulação/métodos
Resultado da Gravidez
[Mh] Termos MeSH secundário: Adulto
Endométrio/cirurgia
Feminino
Seres Humanos
Infertilidade Feminina/tratamento farmacológico
Infertilidade Feminina/fisiopatologia
Infertilidade Feminina/cirurgia
Fase Luteal/fisiologia
Ovulação/fisiologia
Gravidez
Estudos Prospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Fertility Agents, Female); 1HRS458QU2 (Clomiphene)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.1002/ijgo.12178


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[PMID]:28388333
[Au] Autor:Anderson LJ; Baker LL; Schroeder ET
[Ad] Endereço:a University of Southern California.
[Ti] Título:Blunted Myoglobin and Quadriceps Soreness After Electrical Stimulation During the Luteal Phase or Oral Contraception.
[So] Source:Res Q Exerc Sport;88(2):193-202, 2017 Jun.
[Is] ISSN:2168-3824
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Acute muscle damage after exercise triggers subsequent regeneration, leading to hypertrophy and increased strength after repeated exercise. It has been debated whether acute exercise-induced muscle damage is altered under various premenopausal estrogen conditions. Acute contraction-induced muscle damage was compared during exogenous (oral contraceptive, OC), endogenous (luteal phase, HI), or low (menses, LO) estrogen in healthy young women aged 21 to 30 years old. METHODS: Women (OC, n = 9; HI, n = 9; LO, n = 8; total N = 26) performed 1 neuromuscular electrical stimulation (NMES) bout. Soreness, measured via visual analog scale and the Likert Scale of Muscle Soreness for Lower Limb (LSMSLL), quadriceps strength, and plasma myoglobin (Mb), interleukin (IL)-6, IL-8, and granulocyte-colony stimulating factor were measured before and after NMES. RESULTS: NMES performance was similar across groups. Meaningful within-group increases in Mb (effect size [ES] = 1.12) and IL-8 (ES = 0.38) occurred in LO; ES for HI and OC were trivial. ES of the between-group difference in change was moderate for Mb (LO vs. HI = 1.15) and IL-8 (LO vs. HI = 0.86; LO vs. OC = 0.73). 17-ß estradiol correlated moderately and negatively with Mb relative change (r = -.52, p < .05). LO had ~5% greater strength loss than OC and HI. The mean change score for the LSMSLL 2 days post-NMES was clinically greater in LO than OC or HI. CONCLUSIONS: Acute NMES-induced indicators of muscle fiber damage and qualitative muscle soreness may be attenuated during the luteal phase or active OC pill consumption compared with the menstrual phase.
[Mh] Termos MeSH primário: Anticoncepcionais Orais Hormonais/administração & dosagem
Estradiol/sangue
Exercício/fisiologia
Fase Luteal/fisiologia
Mialgia/fisiopatologia
Mioglobina/sangue
[Mh] Termos MeSH secundário: Adulto
Composição Corporal/fisiologia
Estimulação Elétrica
Feminino
Fator Estimulador de Colônias de Granulócitos e Macrófagos/sangue
Seres Humanos
Interleucina-6/sangue
Interleucina-8/sangue
Contração Isométrica/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contraceptives, Oral, Hormonal); 0 (IL6 protein, human); 0 (IL8 protein, human); 0 (Interleukin-6); 0 (Interleukin-8); 0 (Myoglobin); 4TI98Z838E (Estradiol); 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170408
[St] Status:MEDLINE
[do] DOI:10.1080/02701367.2017.1300229


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[PMID]:28357558
[Au] Autor:Zhou W; Zhuang Y; Pan Y; Xia F
[Ad] Endereço:Reproductive Medicine Center, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Canglang District, Suzhou, 215006, Jiangsu, China. zhouweiqin0407@gmail.com.
[Ti] Título:Effects and safety of GnRH-a as a luteal support in women undertaking assisted reproductive technology procedures: follow-up results for pregnancy, delivery, and neonates.
[So] Source:Arch Gynecol Obstet;295(5):1269-1275, 2017 May.
[Is] ISSN:1432-0711
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate the effects and safety of gonadotropin releasing hormone analogue (GnRH-a) as an addition to progesterone luteal support in women who underwent in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) and achieved a clinical pregnancy. METHODS: A retrospective analysis was conducted on 214 patients who underwent IVF/ICSI-ET procedures with standard long mid-luteal protocol, of which 123 received GnRH-a-free protocol and 91 received GnRH-a-added protocol. The patients' pregnancy and delivery course, and their neonates' status at birth and growth/development after birth were statistically compared. RESULTS: There was no significant difference between both study groups regarding embryo risks and maternal complications during early pregnancy. as well as fetal risks during the middle and late stages and neonate risks during birth, except that the twin pregnancies of the GnRH-a-added group had a considerably greater male/female ratio, and a significantly higher rate of premature delivery and low birth weight than those of the GnRH-a-free group. In addition, there was no significant difference in neonate risks within 2 years after birth between both cohorts. CONCLUSION: With precautions taken to control the number of implanted embryos and reduce the incidence of twinning pregnancy, the addition of GnRH-a to luteal support is relatively safe and effective.
[Mh] Termos MeSH primário: Transferência Embrionária/métodos
Fertilização In Vitro/métodos
Hormônio Liberador de Gonadotropina/análogos & derivados
Fase Luteal/fisiologia
Técnicas de Reprodução Assistida
Injeções de Esperma Intracitoplásmicas/métodos
[Mh] Termos MeSH secundário: Adulto
Feminino
Seguimentos
Hormônio Liberador de Gonadotropina/efeitos adversos
Seres Humanos
Recém-Nascido
Gravidez
Taxa de Gravidez
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
33515-09-2 (Gonadotropin-Releasing Hormone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE
[do] DOI:10.1007/s00404-017-4353-5


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[PMID]:28335821
[Au] Autor:Hayashi KG; Hosoe M; Kizaki K; Fujii S; Kanahara H; Takahashi T; Sakumoto R
[Ad] Endereço:Division of Animal Breeding and Reproduction Research, Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization, Tsukuba, 305-0901, Japan.
[Ti] Título:Differential gene expression profiling of endometrium during the mid-luteal phase of the estrous cycle between a repeat breeder (RB) and non-RB cows.
[So] Source:Reprod Biol Endocrinol;15(1):20, 2017 Mar 23.
[Is] ISSN:1477-7827
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Repeat breeding directly affects reproductive efficiency in cattle due to an increase in services per conception and calving interval. This study aimed to investigate whether changes in endometrial gene expression profile are involved in repeat breeding in cows. Differential gene expression profiles of the endometrium were investigated during the mid-luteal phase of the estrous cycle between repeat breeder (RB) and non-RB cows using microarray analysis. METHODS: The caruncular (CAR) and intercaruncular (ICAR) endometrium of both ipsilateral and contralateral uterine horns to the corpus luteum were collected from RB (inseminated at least three times but not pregnant) and non-RB cows on Day 15 of the estrous cycle (4 cows/group). Global gene expression profiles of these endometrial samples were analyzed with a 15 K custom-made oligo-microarray for cattle. Immunohistochemistry was performed to investigate the cellular localization of proteins of three identified transcripts in the endometrium. RESULTS: Microarray analysis revealed that 405 and 397 genes were differentially expressed in the CAR and ICAR of the ipsilateral uterine horn of RB, respectively when compared with non-RB cows. In the contralateral uterine horn, 443 and 257 differentially expressed genes were identified in the CAR and ICAR of RB, respectively when compared with non-RB cows. Gene ontology analysis revealed that genes involved in development and morphogenesis were mainly up-regulated in the CAR of RB cows. In the ICAR of both the ipsilateral and contralateral uterine horns, genes related to the metabolic process were predominantly enriched in the RB cows when compared with non-RB cows. In the analysis of the whole uterus (combining the data above four endometrial compartments), RB cows showed up-regulation of 37 genes including PRSS2, GSTA3 and PIPOX and down-regulation of 39 genes including CHGA, KRT35 and THBS4 when compared with non-RB cows. Immunohistochemistry revealed that CHGA, GSTA3 and PRSS2 proteins were localized in luminal and glandular epithelial cells and stroma of the endometrium. CONCLUSION: The present study showed that endometrial gene expression profiles are different between RB and non-RB cows. The identified candidate endometrial genes and functions in each endometrial compartment may contribute to bovine reproductive performance.
[Mh] Termos MeSH primário: Bovinos/genética
Endométrio/metabolismo
Ciclo Estral/genética
Perfilação da Expressão Gênica/veterinária
Fase Luteal/genética
[Mh] Termos MeSH secundário: Animais
Cruzamento
Cromogranina A/genética
Cromogranina A/metabolismo
Feminino
Perfilação da Expressão Gênica/métodos
Glutationa Transferase/genética
Glutationa Transferase/metabolismo
Imuno-Histoquímica
Análise de Sequência com Séries de Oligonucleotídeos/métodos
Análise de Sequência com Séries de Oligonucleotídeos/veterinária
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Tripsina/genética
Tripsina/metabolismo
Tripsinogênio/genética
Tripsinogênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chromogranin A); 9002-08-8 (Trypsinogen); EC 2.5.1.18 (Glutathione Transferase); EC 3.4.21.4 (Trypsin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE
[do] DOI:10.1186/s12958-017-0237-6


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[PMID]:28333318
[Au] Autor:Tournaye H; Sukhikh GT; Kahler E; Griesinger G
[Ad] Endereço:Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan 101, 1090 Brussels, Belgium.
[Ti] Título:A Phase III randomized controlled trial comparing the efficacy, safety and tolerability of oral dydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization.
[So] Source:Hum Reprod;32(5):1019-1027, 2017 May 01.
[Is] ISSN:1460-2350
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:STUDY QUESTION: Is oral dydrogesterone 30 mg daily (10 mg three times daily [TID]) non-inferior to micronized vaginal progesterone (MVP) 600 mg daily (200 mg TID) for luteal support in in vitro fertilization (IVF), assessed by the presence of fetal heartbeats determined by transvaginal ultrasound at 12 weeks of gestation? SUMMARY ANSWER: Non-inferiority of oral dydrogesterone versus MVP was demonstrated at 12 weeks of gestation, with a difference in pregnancy rate and an associated confidence interval (CI) that were both within the non-inferiority margin. WHAT IS KNOWN ALREADY: MVP is routinely used in most clinics for luteal support in IVF, but it is associated with side effects, such as vaginal irritation and discharge, as well as poor patient acceptance. Dydrogesterone may be an alternative treatment due to its patient-friendly oral administration. STUDY DESIGN, SIZE, DURATION: Lotus I was an international Phase III randomized controlled trial, performed across 38 sites, from August 2013 to March 2016. Subjects were premenopausal women (>18 to <42 years of age; body mass index (BMI) ≥18 to ≤30 kg/m2) with a documented history of infertility who were planning to undergo IVF. A centralized electronic system was used for randomization, and the study investigators, sponsor's study team, and subjects remained blinded throughout the study. PARTICIPANTS/MATERIALS, SETTING, METHODS: In total, 1031 subjects were randomized to receive either oral dydrogesterone (n = 520) or MVP (n = 511). Luteal support was started on the day of oocyte retrieval and continued until 12 weeks of gestation (Week 10), if a positive pregnancy test was obtained at 2 weeks after embryo transfer. MAIN RESULTS AND THE ROLE OF CHANCE: In the full analysis set (FAS), 497 and 477 subjects in the oral dydrogesterone and MVP groups, respectively, had an embryo transfer. Non-inferiority of oral dydrogesterone was demonstrated, with pregnancy rates at 12 weeks of gestation of 37.6% and 33.1% in the oral dydrogesterone and MVP treatment groups, respectively (difference 4.7%; 95% CI: -1.2-10.6%). Live birth rates of 34.6% (172 mothers with 213 newborns) and 29.8% (142 mothers with 158 newborns) were obtained in the dydrogesterone and MVP groups, respectively (difference 4.9%; 95% CI: -0.8-10.7%). Oral dydrogesterone was well tolerated and had a similar safety profile to MVP. LIMITATIONS, REASONS FOR CAUTION: The analysis of the results was powered to consider the clinical pregnancy rate, but the live birth rate may be of greater clinical interest. Conclusions relating to the differences between treatments in live birth rate, observed in this study, should therefore be made with caution. WIDER IMPLICATIONS OF THE FINDINGS: Oral dydrogesterone may replace MVP as the standard of care for luteal phase support in IVF, owing to the oral route being more patient-friendly than intravaginal administration, as well as it being a well tolerated and efficacious treatment. STUDY FUNDING/COMPETING INTEREST(S): Sponsored and supported by Abbott Established Pharmaceuticals Division. H.T.'s institution has received grants from Merck, MSD, Goodlife, Cook, Roche, Besins, Ferring and Mithra (now Allergan) and H.T. has received consultancy fees from Finox, Ferring, Abbott, ObsEva and Ovascience. G.S. has nothing to disclose. E.K. is an employee of Abbott GmbH. G.G. has received investigator fees from Abbott during the conduct of the study; outside of this submitted work, G.G. has received personal fees and non-financial support from MSD, Ferring, Merck-Serono, Finox, TEVA, Glycotope, as well as personal fees from VitroLife, NMC Healthcare LLC, ReprodWissen LLC and ZIVA LLC. TRIAL REGISTRATION NUMBER: NCT01850030 (clinicaltrials.gov). TRIAL REGISTRATION DATE: 19 April 2013. DATE OF FIRST PATIENT'S ENROLLMENT: 23 August 2013.
[Mh] Termos MeSH primário: Didrogesterona/uso terapêutico
Fertilização In Vitro/métodos
Fase Luteal
Progesterona/uso terapêutico
[Mh] Termos MeSH secundário: Administração Intravaginal
Administração Oral
Adulto
Coeficiente de Natalidade
Didrogesterona/administração & dosagem
Didrogesterona/efeitos adversos
Transferência Embrionária/métodos
Feminino
Seres Humanos
Indução da Ovulação/métodos
Gravidez
Resultado da Gravidez
Taxa de Gravidez
Progesterona/administração & dosagem
Progesterona/efeitos adversos
Injeções de Esperma Intracitoplásmicas/métodos
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE III; COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
4G7DS2Q64Y (Progesterone); 90I02KLE8K (Dydrogesterone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1093/humrep/dex023



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