Base de dados : MEDLINE
Pesquisa : G08.686.700 [Categoria DeCS]
Referências encontradas : 1237 [refinar]
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[PMID]:28746312
[Au] Autor:Maretty L; Jensen JM; Petersen B; Sibbesen JA; Liu S; Villesen P; Skov L; Belling K; Theil Have C; Izarzugaza JMG; Grosjean M; Bork-Jensen J; Grove J; Als TD; Huang S; Chang Y; Xu R; Ye W; Rao J; Guo X; Sun J; Cao H; Ye C; van Beusekom J; Espeseth T; Flindt E; Friborg RM; Halager AE; Le Hellard S; Hultman CM; Lescai F; Li S; Lund O; Løngren P; Mailund T; Matey-Hernandez ML; Mors O; Pedersen CNS; Sicheritz-Pontén T; Sullivan P; Syed A; Westergaard D; Yadav R; Li N; Xu X; Hansen T; Krogh A; Bolund L; Sørensen TIA; Pedersen O
[Ad] Endereço:Bioinformatics Centre, Department of Biology, University of Copenhagen, 2200 Copenhagen, Denmark.
[Ti] Título:Sequencing and de novo assembly of 150 genomes from Denmark as a population reference.
[So] Source:Nature;548(7665):87-91, 2017 08 03.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hundreds of thousands of human genomes are now being sequenced to characterize genetic variation and use this information to augment association mapping studies of complex disorders and other phenotypic traits. Genetic variation is identified mainly by mapping short reads to the reference genome or by performing local assembly. However, these approaches are biased against discovery of structural variants and variation in the more complex parts of the genome. Hence, large-scale de novo assembly is needed. Here we show that it is possible to construct excellent de novo assemblies from high-coverage sequencing with mate-pair libraries extending up to 20 kilobases. We report de novo assemblies of 150 individuals (50 trios) from the GenomeDenmark project. The quality of these assemblies is similar to those obtained using the more expensive long-read technology. We use the assemblies to identify a rich set of structural variants including many novel insertions and demonstrate how this variant catalogue enables further deciphering of known association mapping signals. We leverage the assemblies to provide 100 completely resolved major histocompatibility complex haplotypes and to resolve major parts of the Y chromosome. Our study provides a regional reference genome that we expect will improve the power of future association mapping studies and hence pave the way for precision medicine initiatives, which now are being launched in many countries including Denmark.
[Mh] Termos MeSH primário: Variação Genética/genética
Genética Populacional/normas
Genoma Humano/genética
Genômica/normas
Análise de Sequência de DNA/normas
[Mh] Termos MeSH secundário: Adulto
Alelos
Criança
Cromossomos Humanos Y/genética
Dinamarca
Feminino
Haplótipos/genética
Seres Humanos
Complexo Principal de Histocompatibilidade/genética
Masculino
Idade Materna
Taxa de Mutação
Idade Paterna
Mutação Puntual/genética
Padrões de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1038/nature23264


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[PMID]:28535175
[Au] Autor:Wang R; Metayer C; Morimoto L; Wiemels JL; Yang J; DeWan AT; Kang A; Ma X
[Ti] Título:Parental Age and Risk of Pediatric Cancer in the Offspring: A Population-Based Record-Linkage Study in California.
[So] Source:Am J Epidemiol;186(7):843-856, 2017 Oct 01.
[Is] ISSN:1476-6256
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Linking birth records and cancer registry data from California, we conducted a population-based study with 23,419 cases and 87,593 matched controls born during 1978-2009 to investigate the relationship of parental age to risk of pediatric cancer. Compared with children born to mothers aged 20-24 years, those born to mothers in older age groups had a 13%-36% higher risk of pediatric cancer; the odds ratio for each 5-year increase in maternal age was 1.06 (95% confidence interval (CI): 1.04, 1.09). For cancer diagnosed in children in age groups 0-14 years and 15-19 years, the odds ratios for each 5-year increase in maternal age were 1.05 (95% CI: 1.02, 1.07) and 1.14 (95% CI: 1.09, 1.19), respectively. Having an older father also conferred an increased risk, with an odds ratio for each 5-year increase of 1.03 (95% CI: 1.02, 1.05) for cancer diagnosed at ages 0-19 years and 1.03 (95% CI: 1.02, 1.05) for cancer diagnosed at ages 0-14 years. While advancing maternal age increased risk of leukemia and central nervous system tumors, older paternal age was not associated with risk of either type. Both maternal and paternal older ages were associated with risk of lymphoma. In this large, population-based record-linkage study, advancing parental age, especially advancing maternal age, was associated with higher pediatric cancer risk, with variations across types of cancer.
[Mh] Termos MeSH primário: Idade Materna
Neoplasias/etiologia
Idade Paterna
[Mh] Termos MeSH secundário: Adolescente
Adulto
Declaração de Nascimento
California
Estudos de Casos e Controles
Criança
Pré-Escolar
Metilação de DNA
Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
Razão de Chances
Pais
Sistema de Registros
Fatores de Risco
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.1093/aje/kwx160


  3 / 1237 MEDLINE  
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[PMID]:28257590
[Au] Autor:Urhoj SK; Raaschou-Nielsen O; Hansen AV; Mortensen LH; Andersen PK; Nybo Andersen AM
[Ad] Endereço:Section of Social Medicine, Department of Public Health, University of Copenhagen, Oster Farimagsgade 5, POB 2099, DK-1014 Copenhagen K, Denmark.
[Ti] Título:Advanced paternal age and childhood cancer in offspring: A nationwide register-based cohort study.
[So] Source:Int J Cancer;140(11):2461-2472, 2017 Jun 01.
[Is] ISSN:1097-0215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cancer initiation is presumed to occur in utero for many childhood cancers and it has been hypothesized that advanced paternal age may have an impact due to the increasing number of mutations in the sperm DNA with increasing paternal age. We examined the association between paternal age and specific types of childhood cancer in offspring in a large nationwide cohort of 1,904,363 children born in Denmark from 1978 through 2010. The children were identified in the Danish Medical Birth Registry and were linked to information from other national registers, including the Danish Cancer Registry. In total, 3,492 children were diagnosed with cancer before the age of 15 years. The adjusted hazard ratio of childhood cancer according to paternal age was estimated using Cox proportional hazards regressions. We found a 13% (95% confidence interval: 4-23%) higher hazard rate for every 5 years advantage in paternal age for acute lymphoblastic leukemia, while no clear association was found for acute myeloid leukemia (hazard ratio pr. 5 years = 1.02, 95% confidence interval: 0.80-1.30). The estimates for neoplasms in the central nervous system suggested a lower hazard rate with higher paternal age (hazard ratio pr. 5 years = 0.92, 95% confidence interval: 0.84-1.01). No clear associations were found for the remaining childhood cancer types. The findings suggest that paternal age is moderately associated with a higher rate of childhood acute lymphoblastic leukemia, but not acute myeloid leukemia, in offspring, while no firm conclusions could be made for other specific cancer types.
[Mh] Termos MeSH primário: Neoplasias/etiologia
[Mh] Termos MeSH secundário: Adulto
Estudos de Coortes
Dinamarca
Família
Seres Humanos
Meia-Idade
Idade Paterna
Modelos de Riscos Proporcionais
Sistema de Registros
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE
[do] DOI:10.1002/ijc.30677


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[PMID]:28238311
[Au] Autor:Boitrelle F; Plouvier P; Dumont A; Barbotin AL; Rigot JM; Belaïsch-Allart J; Robin G
[Ad] Endereço:Laboratoire de biologie de la reproduction, CHI de Poissy-Saint-Germain-en-Laye, 78303 Poissy, France; EA 7404 GIG, faculté des sciences de la santé Simone-Veil, 78180 Montigny-Le-Bretonneux, France.
[Ti] Título:[Effects of father's age on fertility, results of ART and health of children].
[Ti] Título:Conséquences de l'âge du père sur la fertilité, les résultats de l'AMP et la santé des enfants..
[So] Source:Gynecol Obstet Fertil Senol;45(1):28-31, 2017 Jan.
[Is] ISSN:2468-7189
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Many studies exist on the impact of female age on fertility, success of assisted reproductive technologies and on obstetric, fetal and neonatal adverse outcomes. Late paternity seems commonplace especially in the media… But there are reliable scientific data which confirm decline of fertility related to male age but also an increased risk of genetic diseases for the offspring. The objective of this article is to make a synthesis of the literature on this subject.
[Mh] Termos MeSH primário: Fertilidade/fisiologia
Idade Paterna
Técnicas de Reprodução Assistida
Resultado do Tratamento
[Mh] Termos MeSH secundário: Adulto
Feminino
Feto/fisiologia
Doenças Genéticas Inatas/epidemiologia
Seres Humanos
Recém-Nascido
Masculino
Meia-Idade
Gravidez
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170228
[St] Status:MEDLINE


  5 / 1237 MEDLINE  
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[PMID]:28234951
[Au] Autor:Kato T; Yorifuji T; Yamakawa M; Inoue S; Doi H; Eboshida A; Kawachi I
[Ad] Endereço:Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan.
[Ti] Título:Association of maternal age with child health: A Japanese longitudinal study.
[So] Source:PLoS One;12(2):e0172544, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Average maternal age at birth has been rising steadily in Western and some Asian countries. Older maternal age has been associated with adverse pregnancy and birth outcomes; however, studies on the relationship between maternal age and young children's health remain scarce. Therefore, we sought to investigate the association of maternal age with child health outcomes in the Japanese population. We analyzed data from two birth cohorts of the nationwide Japanese Longitudinal Survey of Babies in 21st Century (n2001 = 47,715 and n2010 = 38,554). We estimated risks of unintentional injuries and hospital admissions at 18 and 66 months according to maternal age, controlling for the following potential confounders: parental education; maternal parity, smoking status, and employment status; household income; paternal age, and sex of the child. We also included the following as potential mediators: preterm births and birthweight. We observed a decreasing trend in the risks of children's unintentional injuries and hospital admissions at 18 months according to maternal age in both cohorts. In the 2001 cohort, compared to mothers <25 years, odds ratios of hospital admission at 18 months were 0.97 [95% CI: 0.86, 1.09], 0.92 [0.81, 1.05], 0.76 [0.65, 0.90], and 0.71 [0.51, 0.98] for mothers aged 25.0-29.9, 30.0-34.9, 35.0-39.9, and >40.0 years, respectively, controlling for confounders. Our findings were in line with previous findings from population-based studies conducted in the United Kingdom and Canada suggesting that older maternal age may be beneficial for early child health.
[Mh] Termos MeSH primário: Peso ao Nascer/fisiologia
Saúde da Criança/tendências
Recém-Nascido Prematuro/crescimento & desenvolvimento
Idade Materna
[Mh] Termos MeSH secundário: Acidentes Domésticos/estatística & dados numéricos
Adulto
Criança
Pré-Escolar
Escolaridade
Emprego/psicologia
Emprego/estatística & dados numéricos
Feminino
Idade Gestacional
Hospitalização/estatística & dados numéricos
Seres Humanos
Recém-Nascido
Japão/epidemiologia
Estudos Longitudinais
Razão de Chances
Paridade/fisiologia
Idade Paterna
Gravidez
Nascimento Prematuro/epidemiologia
Fatores de Risco
Fumar/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172544


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[PMID]:28228319
[Au] Autor:Practice Committee of the American Society for Reproductive Medicine in collaboration with the Society for Reproductive Endocrinology and Infertility. Electronic address: ASRM@asrm.org; Practice Committee of the American Society for Reproductive Medicine in collaboration with the Society for Reproductive Endocrinology and Infertility
[Ti] Título:Optimizing natural fertility: a committee opinion.
[So] Source:Fertil Steril;107(1):52-58, 2017 Jan.
[Is] ISSN:1556-5653
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This Committee Opinion provides practitioners with suggestions for optimizing the likelihood of achieving pregnancy in couples/individuals attempting conception who have no evidence of infertility. This document replaces the document of the same name previously published in 2013, Fertil Steril 2013;100(3):631-7.
[Mh] Termos MeSH primário: Comitês Consultivos/normas
Fertilidade
Saúde Reprodutiva/normas
Medicina Reprodutiva/normas
[Mh] Termos MeSH secundário: Adulto
Dieta
Feminino
Seres Humanos
Estilo de Vida
Idade Materna
Meia-Idade
Ovulação
Detecção da Ovulação/normas
Idade Paterna
Gravidez
Comportamento Sexual
Fatores de Tempo
Tempo para Engravidar
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE


  7 / 1237 MEDLINE  
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[PMID]:28160920
[Au] Autor:Herati AS; Zhelyazkova BH; Butler PR; Lamb DJ
[Ad] Endereço:Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas; Scott Department of Urology, Baylor College of Medicine, Houston, Texas.
[Ti] Título:Age-related alterations in the genetics and genomics of the male germ line.
[So] Source:Fertil Steril;107(2):319-323, 2017 Feb.
[Is] ISSN:1556-5653
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Paternal aging is associated with increased risk of genetic disease transmission to the offspring. The changes associated with aging arise predominantly through formation of single nucleotide variation through DNA replication errors, as well as possibly chronic exposure to environmental toxins and reactive oxygen species exposure. Several age-related reproductive factors are also contributory, including the systemic hormonal milieu, accumulation of environmental toxin exposure, aging germ cells, and accumulation of de novo genetic and genomic abnormalities in germ cells. In this article we review the age-related genetic and genomic changes that occur in the male germ line.
[Mh] Termos MeSH primário: Envelhecimento/genética
Genômica
Idade Paterna
Espermatozoides/patologia
[Mh] Termos MeSH secundário: Fatores Etários
Envelhecimento/metabolismo
Envelhecimento/patologia
Aberrações Cromossômicas
Cromossomos Humanos
Dano ao DNA
Epigênese Genética
Predisposição Genética para Doença
Hereditariedade
Seres Humanos
Masculino
Mutação
Linhagem
Espécies Reativas de Oxigênio/metabolismo
Medição de Risco
Fatores de Risco
Espermatozoides/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Reactive Oxygen Species)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170206
[St] Status:MEDLINE


  8 / 1237 MEDLINE  
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[PMID]:28160919
[Au] Autor:Eisenberg ML; Meldrum D
[Ad] Endereço:Department of Urology, Stanford University School of Medicine, Stanford, California. Electronic address: eisenberg@stanford.edu.
[Ti] Título:Effects of age on fertility and sexual function.
[So] Source:Fertil Steril;107(2):301-304, 2017 Feb.
[Is] ISSN:1556-5653
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:As paternal age increases in the developed world, more attention has been given to the effects of age on male reproductive and sexual function. Although the biologic potential for reproductive continues for most of a man's life, changes in sperm production do occur. In addition, erectile function changes with age, caused by the same factors that lead to other vascular disease.
[Mh] Termos MeSH primário: Fertilidade
Idade Paterna
Saúde Reprodutiva
Comportamento Sexual
[Mh] Termos MeSH secundário: Fatores Etários
Disfunção Erétil/etiologia
Disfunção Erétil/fisiopatologia
Seres Humanos
Infertilidade Masculina/etiologia
Infertilidade Masculina/patologia
Infertilidade Masculina/fisiopatologia
Masculino
Ereção Peniana
Fatores de Risco
Espermatogênese
Espermatozoides/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170206
[St] Status:MEDLINE


  9 / 1237 MEDLINE  
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[PMID]:28160918
[Au] Autor:Sigman M
[Ad] Endereço:Warren Alpert Medical School of Brown University and the Miriam and Rhode Island Hospitals, Providence, Rhode Island. Electronic address: mark_sigman@brown.edu.
[Ti] Título:Introduction: What to do with older prospective fathers: the risks of advanced paternal age.
[So] Source:Fertil Steril;107(2):299-300, 2017 Feb.
[Is] ISSN:1556-5653
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Increasing numbers of men are attempting conception at older ages. Adverse changes in male fertility and sexual function occur with age. In addition, there are potential consequences for children born to older fathers-some medical and some psychological. This month's Views and Reviews section discusses the biologic changes in reproductive function, medical conditions that increase with age that affect reproductive function, the risks to children of older fathers, genetic mechanisms responsible for these risks, and issues clinicians should know to be able to counsel these couples.
[Mh] Termos MeSH primário: Fertilidade
Infertilidade Masculina/etiologia
Idade Paterna
Saúde Reprodutiva
[Mh] Termos MeSH secundário: Fatores Etários
Relações Pai-Filho
Feminino
Seres Humanos
Infertilidade Masculina/genética
Infertilidade Masculina/fisiopatologia
Infertilidade Masculina/terapia
Masculino
Gravidez
Taxa de Gravidez
Técnicas de Reprodução Assistida/efeitos adversos
Fatores de Risco
Espermatozoides/patologia
Resultado do Tratamento
[Pt] Tipo de publicação:INTRODUCTORY JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170206
[St] Status:MEDLINE


  10 / 1237 MEDLINE  
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[PMID]:28135188
[Au] Autor:Martin JA; Hamilton BE; Osterman MJ; Driscoll AK; Mathews TJ
[Ti] Título:Births: Final Data for 2015.
[So] Source:Natl Vital Stat Rep;66(1):1, 2017 Jan.
[Is] ISSN:1551-8922
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Objectives-This report presents 2015 data on U.S. births according to a wide variety of characteristics. Data are presented for maternal age, live-birth order, race and Hispanic origin, marital status, attendant at birth, method of delivery, period of gestation, birthweight, and plurality. Selected data by mother's state of residence and birth rates by age and race of father also are shown. Trends in fertility patterns and maternal and infant characteristics are described and interpreted. Methods-Descriptive tabulations of data reported on the birth certificates of the 3.98 million births that occurred in 2015 are presented. Results-In 2015, 3,978,497 births were registered in the United States, down less than 1% from 2014. The general fertility rate was 62.5 per 1,000 women aged 15-44, a decline of 1% from 2014. The birth rate for teenagers aged 15-19 fell 8% in 2015, to 22.3 per 1,000 females. Birth rates declined for women in their 20s but increased for women in their 30s and early 40s. The total fertility rate (estimated number of births over a woman's lifetime) declined to 1,843.5 births per 1,000 women in 2015. The birth rate for unmarried women declined for the seventh straight year to 43.5 per 1,000. The cesarean delivery rate declined for the third year in a row to 32.0%. The preterm birth rate increased slightly from 2014, to 9.63% in 2015, as did the rate of low birthweight (8.07% in 2015). The twin birth rate declined to 33.5 per 1,000; the triplet and higher-order multiple birth rate was down 9% to 103.6 per 100,000.
[Mh] Termos MeSH primário: Coeficiente de Natalidade/tendências
[Mh] Termos MeSH secundário: Ordem de Nascimento
Coeficiente de Natalidade/etnologia
Peso ao Nascer
Parto Obstétrico/métodos
Grupos Étnicos/estatística & dados numéricos
Feminino
Idade Gestacional
Seres Humanos
Recém-Nascido de Baixo Peso
Recém-Nascido
Recém-Nascido Prematuro
Masculino
Estado Civil
Idade Materna
Prole de Múltiplos Nascimentos/estatística & dados numéricos
Idade Paterna
Gravidez
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170131
[St] Status:MEDLINE



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