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[PMID]:29385186
[Au] Autor:Eladak S; Moison D; Guerquin MJ; Matilionyte G; Kilcoyne K; N'Tumba-Byn T; Messiaen S; Deceuninck Y; Pozzi-Gaudin S; Benachi A; Livera G; Antignac JP; Mitchell R; Rouiller-Fabre V; Habert R
[Ad] Endereço:Univ. Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Genetic Stability, Stem Cells and Radiation, Fontenay-aux-Roses, France.
[Ti] Título:Effects of environmental Bisphenol A exposures on germ cell development and Leydig cell function in the human fetal testis.
[So] Source:PLoS One;13(1):e0191934, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Using an organotypic culture system termed human Fetal Testis Assay (hFeTA) we previously showed that 0.01 µM BPA decreases basal, but not LH-stimulated, testosterone secreted by the first trimester human fetal testis. The present study was conducted to determine the potential for a long-term antiandrogenic effect of BPA using a xenograft model, and also to study the effect of BPA on germ cell development using both the hFETA and xenograft models. METHODS: Using the hFeTA system, first trimester testes were cultured for 3 days with 0.01 to 10 µM BPA. For xenografts, adult castrate male nude mice were injected with hCG and grafted with first trimester testes. Host mice received 10 µM BPA (~ 500 µg/kg/day) in their drinking water for 5 weeks. Plasma levels of total and unconjugated BPA were 0.10 µM and 0.038 µM respectively. Mice grafted with second trimester testes received 0.5 and 50 µg/kg/day BPA by oral gavage for 5 weeks. RESULTS: With first trimester human testes, using the hFeTA model, 10 µM BPA increased germ cell apoptosis. In xenografts, germ cell density was also reduced by BPA exposure. Importantly, BPA exposure significantly decreased the percentage of germ cells expressing the pluripotency marker AP-2γ, whilst the percentage of those expressing the pre-spermatogonial marker MAGE-A4 significantly increased. BPA exposure did not affect hCG-stimulated androgen production in first and second trimester xenografts as evaluated by both plasma testosterone level and seminal vesicle weight in host mice. CONCLUSIONS: Exposure to BPA at environmentally relevant concentrations impairs germ cell development in first trimester human fetal testis, whilst gonadotrophin-stimulated testosterone production was unaffected in both first and second trimester testis. Studies using first trimester human fetal testis demonstrate the complementarity of the FeTA and xenograft models for determining the respective short-term and long term effects of environmental exposures.
[Mh] Termos MeSH primário: Compostos Benzidrílicos/toxicidade
Poluentes Ambientais/toxicidade
Células Intersticiais do Testículo/efeitos dos fármacos
Fenóis/toxicidade
Espermatozoides/efeitos dos fármacos
Testículo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Feminino
Xenoenxertos
Seres Humanos
Masculino
Camundongos
Camundongos Nus
Gravidez
Primeiro Trimestre da Gravidez
Segundo Trimestre da Gravidez
Radioimunoensaio
Reação em Cadeia da Polimerase em Tempo Real
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Testículo/citologia
Testículo/embriologia
Testosterona/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Environmental Pollutants); 0 (Phenols); 3XMK78S47O (Testosterone); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191934


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[PMID]:29406042
[Au] Autor:Li P; Lin S; Cui J; Li L; Zhou S; Fan J
[Ad] Endereço:Department of Obstetrics and Gynecology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
[Ti] Título:First Trimester Neck Circumference as a Predictor for the Development of Gestational Diabetes Mellitus.
[So] Source:Am J Med Sci;355(2):149-152, 2018 Feb.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUNDS: This study aimed to evaluate the relationship between neck circumference (NC) and gestational diabetes mellitus (GDM), and the efficacy of NC in predicting GDM by comparing with pregestational body mass index (preBMI) in southern Chinese woman. MARERIALS AND METHODS: A total of 371 pregnant women (97 GDM and 274 normal pregnant women) were recruited from the third affiliated hospital of Sun Yat-Sen University, Guangzhou, China. NC was measured at 11-13 gestational weeks. GDM was diagnosed through a 75-g oral glucose tolerance test at 24-28 gestational weeks. Using the receiver-operator characteristic (ROC) curve analysis, we evaluated the association between NC and GDM. RESULTS: The area under the receiver operator characteristic curves were 0.65 (95% CI: 0.60-0.70) for NC and 0.64 (95% CI: 0.59-0.69) for preBMI in diagnosing GDM and no difference was found between them (P = 0.66). NC ≥ 33.8cm was determined to be the best cut-off level for identifying subjects with GDM (sensitivity 68.04% and specificity 59.12%). Multivariate logistic regression analysis showed that a large NC in the first trimester was an independent risk factor for the development of GDM (odds ratio [OR] = 1.29, 95% CI: 1.72-7.45). CONCLUSIONS: NC, as well as preBMI, might be a novel anthropometric index for GDM screening. The increase of NC could be an independent risk factor for GDM in first trimester pregnancy.
[Mh] Termos MeSH primário: Tamanho Corporal
Diabetes Gestacional/patologia
Pescoço/patologia
Primeiro Trimestre da Gravidez
[Mh] Termos MeSH secundário: Adulto
Grupo com Ancestrais do Continente Asiático
China
Diabetes Gestacional/diagnóstico
Feminino
Seres Humanos
Valor Preditivo dos Testes
Gravidez
Fatores de Risco
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:27770542
[Au] Autor:Shen ZQ; Gao SY; Li SX; Zhang TN; Liu CX; Lv HC; Zhang Y; Gong TT; Xu X; Ji C; Wu QJ; Li D
[Ad] Endereço:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
[Ti] Título:Sertraline use in the first trimester and risk of congenital anomalies: a systemic review and meta-analysis of cohort studies.
[So] Source:Br J Clin Pharmacol;83(4):909-922, 2017 04.
[Is] ISSN:1365-2125
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: To perform a meta-analysis of available cohort studies on the association between sertraline use by pregnant women in the first trimester and the findings of congenital anomalies in infants. METHODS: A comprehensive search of articles published from the index date up to 31 December 2015 investigating the aforementioned associations was conducted on PubMed and Web of Science. Mesh headings used included the terms "serotonin reuptake inhibitor," "sertraline," "congenital anomalies" and "obstetrical outcome." RESULTS: Twelve cohort studies that involved 6 468 241 pregnant women were identified. We summarized odds ratios (ORs) and 95% confidence intervals (CIs) of congenital anomalies using the random-effects model. Pregnant women who used sertraline in the first trimester had a statistically significant increased risk of infant cardiovascular-related malformations (OR = 1.36; 95% CI = 1.06-1.74; I  = 64.4%; n = 12) as well as atrial and/or ventricular septal defects (OR = 1.36, 95% CI = 1.06-1.76; I  = 62.2%; n = 8). Additionally, positive but nonsignificant associations between sertraline use and congenital anomalies of the nervous system (OR = 1.39; 95% CI = 0.83-2.32; I  = 0%; n = 5), digestive system (OR = 1.23; 95% CI = 0.76-1.98; I  = 0%; n = 5), eye, ear, face and neck (OR = 1.08; 95% CI = 0.33-3.55; I  = 32.1%; n = 3), urogenital system (OR = 1.03; 95% CI = 0.73-1.46; I  = 0%; n = 5), and musculoskeletal system (OR = 0.97; 95% CI = 0.69-1.36; I  = 0%; n = 5) were observed. CONCLUSION: This meta-analysis suggested that the use of sertraline use by pregnant women in the first trimester had an increased risk of cardiovascular-related malformations as well as atrial and/or ventricular septal defects in infants. Meanwhile, nonsignificant associations between sertraline use and other congenital anomalies were found. More cohort studies are warranted to provide detailed results of other congenital anomalies.
[Mh] Termos MeSH primário: Anormalidades Induzidas por Medicamentos/etiologia
Inibidores da Captação de Serotonina/administração & dosagem
Sertralina/administração & dosagem
[Mh] Termos MeSH secundário: Anormalidades Induzidas por Medicamentos/epidemiologia
Estudos de Coortes
Feminino
Seres Humanos
Lactente
Gravidez
Primeiro Trimestre da Gravidez
Risco
Inibidores da Captação de Serotonina/efeitos adversos
Sertralina/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Serotonin Uptake Inhibitors); QUC7NX6WMB (Sertraline)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE
[do] DOI:10.1111/bcp.13161


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[PMID]:28461175
[Au] Autor:Cohen SB; Bouaziz J; Bar-On A; Schiff E; Goldenberg M; Mashiach R
[Ad] Endereço:Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Tel Aviv, Israel; Department of Obstetrics and Gynecology, Herzliya Medical Center, Herzliya, Israel.
[Ti] Título:In-office Hysteroscopic Extraction of Intrauterine Devices in Pregnant Patients Who Underwent Prior Ultrasound-guided Extraction Failure.
[So] Source:J Minim Invasive Gynecol;24(5):833-836, 2017 Jul - Aug.
[Is] ISSN:1553-4669
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:STUDY OBJECTIVE: To determine an effective method of intrauterine device (IUD) retrieval from pregnant women who had previous unsuccessful ultrasound-guided IUD extraction failure. DESIGN: A retrospective cohort study (Canadian task force classification II-1). SETTING: A gynecology department of an outpatient clinic. PATIENTS: Pregnant patients in their first trimester with IUD in situ who underwent prior unsuccessful ultrasound-guided IUD extraction. INTERVENTIONS: Hysteroscopic IUD extraction guided by transabdominal ultrasound. MEASUREMENTS AND MAIN RESULTS: Between 2011 and 2014, 7 of 8 pregnant patients who had undergone previous failed attempts at IUD retrieval via ultrasound guidance underwent successful removal via ultrasound-guided hysteroscopy performed without anesthesia. The sole patient with extraction failure was in her 12th week of pregnancy, and the procedure was concluded to avoid risk to the fetus. Minimal vaginal bleeding was experienced by 2 patients after the procedure. Seven of 8 patients delivered at term without any obstetric complications. One patient had a miscarriage in her 8th week of pregnancy, 2 weeks after successful IUD removal. CONCLUSION: A novel, easy outpatient hysteroscopic technique without anesthesia is presented in case of failure of previous ultrasound-guided IUD removal in early pregnancy. Results are encouraging in this difficult context.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Ambulatórios/métodos
Remoção de Dispositivo/métodos
Histeroscopia/métodos
Dispositivos Intrauterinos
Complicações na Gravidez/cirurgia
Reoperação/métodos
Ultrassonografia de Intervenção/métodos
[Mh] Termos MeSH secundário: Aborto Espontâneo/epidemiologia
Aborto Espontâneo/etiologia
Adulto
Procedimentos Cirúrgicos Ambulatórios/efeitos adversos
Eficácia de Contraceptivos
Remoção de Dispositivo/efeitos adversos
Falha de Equipamento
Feminino
Seres Humanos
Histeroscopia/efeitos adversos
Migração de Dispositivo Intrauterino
Gravidez
Primeiro Trimestre da Gravidez
Reoperação/efeitos adversos
Estudos Retrospectivos
Ultrassonografia de Intervenção/efeitos adversos
Ultrassonografia Pré-Natal/métodos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:29293682
[Au] Autor:Winger EE; Reed JL; Ji X; Nicolaides K
[Ad] Endereço:Laboratory for Reproductive Medicine & Immunology, San Francisco, California, United States of America.
[Ti] Título:Peripheral blood cell microRNA quantification during the first trimester predicts preeclampsia: Proof of concept.
[So] Source:PLoS One;13(1):e0190654, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We investigated the capacity of microRNAs isolated from peripheral blood buffy coat collected late during the first trimester to predict preeclampsia. STUDY DESIGN: The cohort study comprised 48 pregnant women with the following pregnancy outcomes: 8 preeclampsia and 40 with normal delivery outcomes. Quantitative rtPCR was performed on a panel of 30 microRNAs from buffy coat samples drawn at a mean of 12.7±0.5 weeks gestation. MicroRNA Risk Scores were calculated and AUC-ROC calculations derived. RESULTS: The AUC-ROC for preeclampsia risk was 0.91 (p<0.0001). When women with normal delivery and high-risk background (those with SLE/APS, chronic hypertension and/or Type 2 Diabetes) were compared to women who developed preeclampsia but with a normal risk background (without these mentioned risk factors), preeclampsia was still predicted with an AUC-ROC of 0.92 (p<0.0001). CONCLUSION: MicroRNA quantification of peripheral immune cell microRNA provides sensitive and specific prediction of preeclampsia in the first trimester of pregnant women. With this study, we extend the range during which disorders of the placental bed may be predicted from early to the end of the first trimester. This study confirms that buffy coat may be used as a sample preparation.
[Mh] Termos MeSH primário: MicroRNAs/sangue
Pré-Eclâmpsia/sangue
Primeiro Trimestre da Gravidez/sangue
[Mh] Termos MeSH secundário: Adulto
Estudos de Coortes
Feminino
Seres Humanos
Gravidez
Curva ROC
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (MicroRNAs)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190654


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[PMID]:29328643
[Au] Autor:Grujic Z; Grujic I; Bogavac M; Nikolic A; Mitic R; Stajic Z
[Ti] Título:Disturbance of oxidative balance in the first trimester of spontaneous abortions.
[So] Source:Vojnosanit Pregl;73(11):1038-43, 2016 Nov.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Pregnancy is defined as a condition of increased oxidative stress. The aim of this research was to determine the intensity of pro-oxidative processes and the content of GSH, as well as antioxidative enzymes: superoxide dismutase (SOD), catalase (CAT), gluthatione peroxidase (GSH-Px), and the total antioxidative status (TAS) in patients with spontaneous abortions. Methods: A total of 120 patients were involved in the research (70 spontaneous abortions and 50 healthy pregnancies). The patients were divided into groups: 35 patients with incomplete and complete spontaneous abortion (group S), 35 patients with missed abortion (group M) and a control group of 50 healthy pregnancies (group N), all of them being in the first trimester of pregnancy. The intensity of lipid proxidation (LPx) was determined with a modified thyobarbituric acid method. The GSH content in erythrocytes was determined by the method ba-sed on the amount of non-protein sulfhydryl residues using the Ellman's reagens. The following antioxidative parameters in the blood were measured: SOD ­ by the method with xanthine oxidase-using commercial RANSOD sets; CAT ­ by the method of Aebi (the enzyme activity was measured by monitoring the decomposition of H2O2 at 240 nm); GSH-Px was determined using hydrogen peroxide as a substrate. The TAS was determined using the ferric reducing autioxidant potential (FRAP) met-hod. Results: The highest average value of LPx was recorded in the spontaneous abortion group (48.03 pmoL/mg Hgb), and the lowest value was recorded in the control group (26.06 pmoL/mg Hgb). A statistically significant positive correlation between LPx and CAT in the group of patients with missed abortion was also noted (p < 0.05, r = 0.37). There was a statistically highly significant difference (p < 0.001) in SOD and in CAT activitices be-tween the examined patients (groups S and N) and the control group (Student's t-test and ANOVA). The highest average value of TAS was recorded in the group S (710.39 µmol/L), while the value in the group M was 277.66 µmol/L. The average value of TAS in the control group was 452.12 µmol/L. Student's t-test showed a statistically highly significant difference in the values of TAS between the examined patients (groups S and M) and the control group. Conclusion: Determination of the value of pro-oxidative and antioxidative parameters in patients with sponta-neous abortion can be the indicator of condition of fetoplacental unit and these analyses can be included in the protocol of the rutine perinatal diagnostics.
[Mh] Termos MeSH primário: Aborto Espontâneo/sangue
Estresse Oxidativo
Primeiro Trimestre da Gravidez/sangue
[Mh] Termos MeSH secundário: Aborto Espontâneo/fisiopatologia
Adulto
Antioxidantes/metabolismo
Biomarcadores/sangue
Estudos de Casos e Controles
Catalase/sangue
Feminino
Glutationa/sangue
Glutationa Peroxidase/sangue
Seres Humanos
Peroxidação de Lipídeos
Gravidez
Estudos Prospectivos
Superóxido Dismutase/sangue
Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biomarkers); 0 (Thiobarbituric Acid Reactive Substances); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150321123G


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[PMID]:29369548
[Au] Autor:Mashkina EV; Kovalenko KA; Marakhovskaya TA; Saraev KN; Belanova AA; Shkurat TP
[Ti] Título:[Association of gene polymorphisms of matrix metalloproteinases with reproductive losses in the first trimester of pregnancy].
[So] Source:Genetika;52(8):958-65, 2016 Aug.
[Is] ISSN:0016-6758
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:In the present study, the frequencies of genotypes and alleles of candidate genes with respect to polymorphisms associated with increased pregnancy loss in the first trimester of pregnancy, including MMP1­1607insG, MMP9 A­8202G, and TIMP1 С536T, were reported. The frequency of homozygotes for allele MMP9 A­8202 was increased by a factor of two among women with miscarriage in the first trimester compared to the control. Significant models of interaction of genes MMPs and TIMP1 were revealed. The genotypes of genes MMP1 (rs1799750), MMP9 (rs11697325), and TIMP1 (rs11551797) increasing the risk of pregnancy loss in the first trimester were determined.
[Mh] Termos MeSH primário: Aborto Espontâneo/genética
Alelos
Frequência do Gene
Metaloproteinase 1 da Matriz/genética
Metaloproteinase 9 da Matriz/genética
Polimorfismo Genético
Primeiro Trimestre da Gravidez/genética
[Mh] Termos MeSH secundário: Aborto Espontâneo/enzimologia
Adulto
Feminino
Seres Humanos
Metaloproteinase 1 da Matriz/metabolismo
Metaloproteinase 9 da Matriz/metabolismo
Gravidez
Primeiro Trimestre da Gravidez/metabolismo
Inibidor Tecidual de Metaloproteinase-1/genética
Inibidor Tecidual de Metaloproteinase-1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (TIMP1 protein, human); 0 (Tissue Inhibitor of Metalloproteinase-1); EC 3.4.24.35 (MMP9 protein, human); EC 3.4.24.35 (Matrix Metalloproteinase 9); EC 3.4.24.7 (MMP1 protein, human); EC 3.4.24.7 (Matrix Metalloproteinase 1)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


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[PMID]:29290632
[Au] Autor:Markou GA; Dafereras G; Poncelet C
[Ad] Endereço:Department of Obstetrics and Gynecology, Rene-Dubos Hospital, Cergy-Pontoise, France.
[Ti] Título:Congenital Cystic Adenomatoid Malformation Diagnosed During First-Trimester Ultrasound Scan.
[So] Source:Am J Case Rep;19:1-4, 2018 Jan 01.
[Is] ISSN:1941-5923
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Congenital cystic adenomatoid malformation (CCAM) is mostly reported from the second trimester of pregnancy. We report a case of a microcystic type of CCAM that was suggested by routine ultrasound examination at a gestational age of 12 weeks. CASE REPORT First-trimester ultrasound screening revealed the presence of a hyperechoic image that occupied the whole of the right lung, without no other any associated complications. The cardiac and aorta deviations with diaphragmatic eversion associated with a poly-hydramnios had subsequently appeared. The diagnosis of CCAM was confirmed histologically after termination of the pregnancy at 25 weeks of gestation. CONCLUSIONS CCAM may occur at a very early stage of fetal lung development.
[Mh] Termos MeSH primário: Malformação Adenomatoide Cística Congênita do Pulmão/diagnóstico por imagem
Primeiro Trimestre da Gravidez
Ultrassonografia Pré-Natal
[Mh] Termos MeSH secundário: Aborto Terapêutico
Adulto
Malformação Adenomatoide Cística Congênita do Pulmão/cirurgia
Diagnóstico Diferencial
Feminino
Seres Humanos
Gravidez
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180102
[St] Status:MEDLINE


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[PMID]:29324733
[Au] Autor:Ailes EC; Summers AD; Tran EL; Gilboa SM; Arnold KE; Meaney-Delman D; Reefhuis J
[Ti] Título:Antibiotics Dispensed to Privately Insured Pregnant Women with Urinary Tract Infections - United States, 2014.
[So] Source:MMWR Morb Mortal Wkly Rep;67(1):18-22, 2018 Jan 12.
[Is] ISSN:1545-861X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Urinary tract infections (UTIs) occur in about 8% of pregnant women, and untreated UTIs can have serious consequences, including pyelonephritis, preterm labor, low birth weight, and sepsis (1). Pregnant women are typically screened for UTIs during early pregnancy, and those with bacteriuria are treated with antibiotics (1,2). Antibiotic stewardship is critical to improving patient safety and to combating antibiotic resistance. Because of the potential risk for birth defects, including anencephaly, heart defects, and orofacial clefts, associated with use of sulfonamides and nitrofurantoin during pregnancy (3), a 2011 committee opinion from the American College of Obstetricians and Gynecologists (ACOG) recommended that sulfonamides and nitrofurantoin may be prescribed in the first trimester of pregnancy only when other antimicrobial therapies are deemed clinically inappropriate (4). To assess the effects of these recommendations, CDC analyzed the Truven Health MarketScan Commercial Database* to examine antibiotic prescriptions filled by pregnant women with UTIs. Among 482,917 pregnancies in 2014, 7.2% of women had an outpatient UTI diagnosis during the 90 days before the date of last menstrual period (LMP) or during pregnancy. Among pregnant women with UTIs, the most frequently prescribed antibiotics during the first trimester were nitrofurantoin, ciprofloxacin, cephalexin, and trimethoprim-sulfamethoxazole. Given the potential risks associated with use of some of these antibiotics in early pregnancy and the potential for unrecognized pregnancy, women's health care providers should be familiar with the ACOG recommendations and consider the possibility of early pregnancy when treating women of reproductive age.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Prescrições de Medicamentos/estatística & dados numéricos
Seguro Saúde/estatística & dados numéricos
Setor Privado
Infecções Urinárias/tratamento farmacológico
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Guias de Prática Clínica como Assunto
Gravidez
Primeiro Trimestre da Gravidez
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.15585/mmwr.mm6701a4


  10 / 14905 MEDLINE  
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Texto completo
[PMID]:29266076
[Au] Autor:Committee on Practice Bulletins-Obstetrics
[Ti] Título:ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy.
[So] Source:Obstet Gynecol;131(1):e15-e30, 2018 01.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nausea and vomiting of pregnancy is a common condition that affects the health of a pregnant woman and her fetus. It can diminish a woman's quality of life and also significantly contributes to health care costs and time lost from work (1, 2). Because morning sickness is common in early pregnancy, the presence of nausea and vomiting of pregnancy may be minimized by obstetricians, other obstetric care providers, and pregnant women and, thus, undertreated (1). Furthermore, some women do not seek treatment because of concerns about the safety of medications (3). Once nausea and vomiting of pregnancy progresses, it can become more difficult to control symptoms. Treatment in the early stages may prevent more serious complications, including hospitalization (4). Safe and effective treatments are available for more severe cases, and mild cases of nausea and vomiting of pregnancy may be resolved with lifestyle and dietary changes. The woman's perception of the severity of her symptoms plays a critical role in the decision of whether, when, and how to treat nausea and vomiting of pregnancy. Nausea and vomiting of pregnancy should be distinguished from nausea and vomiting related to other causes. The purpose of this document is to review the best available evidence about the diagnosis and management of nausea and vomiting of pregnancy.
[Mh] Termos MeSH primário: Antieméticos/administração & dosagem
Saúde Materna
Êmese Gravídica/prevenção & controle
Guias de Prática Clínica como Assunto
Primeiro Trimestre da Gravidez
[Mh] Termos MeSH secundário: Comitês Consultivos/normas
Antieméticos/farmacologia
Medicina Baseada em Evidências
Feminino
Seres Humanos
Êmese Gravídica/tratamento farmacológico
Náusea/tratamento farmacológico
Náusea/fisiopatologia
Obstetrícia/normas
Gravidez
Resultado da Gravidez
Índice de Gravidade de Doença
Estados Unidos
Vômito/tratamento farmacológico
Vômito/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Antiemetics)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000002456



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