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[PMID]:29265787
[Au] Autor:Bzikowska A; Czerwonogrodzka-Senczyna A; Riahi A; Weker H
[Ad] Endereço:Warsaw Medical University, Faculty of Health Science, Department of Clinical Dietetics, Warsaw, Poland
[Ti] Título:Nutritional value of daily food rations of overweight and normal weight pregnant women
[So] Source:Rocz Panstw Zakl Hig;68(4):375-379, 2017.
[Is] ISSN:0035-7715
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Background: Adequate nutrition and nutritional status during pregnancy are essential for mother's health and foetus development. Due to increased demands, pregnant women are vulnerable to inadequate nutritional status and paradoxically it may also affect overweight women Objective: The aim of the study was to evaluate energy and nutrients intake in the group of pregnant women in relation to nutritional standards and pre-pregnancy BMI Material and methods: The study included 90 women, during the third trimester of pregnancy, recruited from Warsaw antenatal classes. The anthropometric data gathered in the research were used to calculate BMI value before pregnancy. Pre-pregnancy BMI was categorised as: normal weight (BMI=18.5-24.9 kg/m2, n=47) and overweight (BMI ≥25.0 kg/m2, n=43). The assessment of women's nutrition was based on 3-days dietary record. Due to heterogeneous variances, differences between groups were assessed using Mann Whitney U test, p<0.05 was considered as significant Results: The mean intake of energy, protein, fat and carbohydrates in the overweight women were significantly higher than in healthy weight women (p<0.05). Most of the healthy weight women did not reach EAR standard for vitamin D (79.5%), whereas in overweight group it was 41.3% Conclusions: Despite the fact that intakes of energy and all nutrients were higher in overweight women than in normal weight ones, we observed that women in both groups had risk of insufficient supply of energy, iodine, potassium and vitamin D. For this reason, accurate nutritional assessment should be an integral part of obstetric care
[Mh] Termos MeSH primário: Dieta
Estado Nutricional
Valor Nutritivo
Terceiro Trimestre da Gravidez
Fenômenos Fisiológicos da Nutrição Pré-Natal
[Mh] Termos MeSH secundário: Índice de Massa Corporal
Registros de Dieta
Feminino
Seres Humanos
Peso Corporal Ideal
Avaliação Nutricional
Sobrepeso
Polônia
Gravidez
Cuidado Pré-Natal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


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[PMID]:29325266
[Au] Autor:Hu MN; Zhang Y; Zhao W
[Ad] Endereço:Department of Health Care, Haidian Maternal and Child Health Hospital, Beijing 100080, China.
[Ti] Título:[Analysis of 649 cases of stillbirth in third trimester].
[So] Source:Zhonghua Fu Chan Ke Za Zhi;52(12):822-827, 2017 Dec 25.
[Is] ISSN:0529-567X
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To analyze the risk factors of stillbirth in third trimester. Clinical data of 649 cases of stillbirth in third trimester were analyzed retrospectively in 22 hospitals of Haidian district from October 2011 to September 2016, including the incidence, the maternal profile, the perinatal care during pregnancy and the causes of stillbirth. (1) The incidence of stillbirth in third trimester in Haidian district from October 2011 to September 2016 was 0.293%(649/221 845). While the incidence in floating pregnant women (0.349%, 342/97 939) was higher than that in the residence (0.248%, 307/123 906), with statistically significant difference (χ(2)=19.178, <0.01). The incidence of stillbirth in multiple pregnancy(0.201%, 89/4 264) was higher than that in singleton pregnancy (0.257%, 560/217 581), with statistically significant difference(χ(2)=4.690, <0.01). There was no statistically significant difference in the incidence of stillbirth between male (0.300%, 347/115 632) and female fetuses (0.284%, 302/106 205; χ(2)=0.467, >0.05).(2)Among the 649 cases, the floating population accounted for the majority of those who never had prenatal visit (84.0%, 21/25), or less than 5 visits (80.7%, 125/155), or the first visit was beyond 13 gestational weeks(66.0%, 165/649). The causes of stillbirth in order were fetal factors (30.7%, 199/649), maternal factors(28.0%, 182/649), umbilical cord factors (20.0%, 130/649), unexplained factors (17.6%, 114/649) and placental factors (3.7%, 24/649). Birth defects, pregnancy hypertensive disorders, umbilical cord entanglement or torsion were the most important factors, accounting for 22.8%(148/649), 17.4%(113/649), 17.3%(112/649), respectively. The floating pregnant women are key population of stillbirth in third trimester. Maternal care and education should be strengthened in this population. The prevention of birth defect, better prenatal care in women with complications, and close monitor during labor are the key measures to reduce the incidence of stillbirth in third trimester.
[Mh] Termos MeSH primário: Complicações na Gravidez/epidemiologia
Terceiro Trimestre da Gravidez
Natimorto/epidemiologia
[Mh] Termos MeSH secundário: Adulto
China/epidemiologia
Feminino
Feto
Seres Humanos
Placenta
Gravidez
Cuidado Pré-Natal
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-567x.2017.12.006


  3 / 13321 MEDLINE  
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[PMID]:29363527
[Au] Autor:Vasileiou V; Kyratzoglou E; Paschou SA; Kyprianou M; Anastasiou E
[Ad] Endereço:Department of Endocrinology and Diabetes'Alexandra' Hospital, Athens, Greece.
[Ti] Título:The impact of environmental temperature on the diagnosis of gestational diabetes mellitus.
[So] Source:Eur J Endocrinol;178(3):209-214, 2018 Mar.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate a probable impact of seasons on the diagnosis of GDM, as well as the specific effect of the environmental temperature on the diagnosis of this clinical entity. PATIENTS AND METHODS: Two observational studies, one retrospective and one prospective, were conducted in a referral center. Study A included retrospectively 7618 pregnant women who underwent a 3-h 100 g OGTT during the 3rd trimester of gestation. Study B prospectively included 768 pregnant women tested in the 3rd trimester of gestation with a 75 g OGTT. Temperature was recorded every day at 09:00 h. RESULTS: Retrospective Study A: GDM prevalence differed significantly by season: winter = 28.1%, summer = 39.2%, spring = 32.4% and autumn = 32.4% ( < 0.0001). The odds ratio for being diagnosed with GDM was much higher during summer 1.65 (95% CI: 1.43-1.90), with spring and autumn following with 1.23 (95% CI: 1.08-1.39) compared to winter. Glucose levels during OGTT were measured: significantly increased blood glucose values were observed at 60, 120 and 180 min in summer, which remained significant after adjustment for age, gestational age, BMI, weight gain during pregnancy and blood pressure. Prospective Study B: At temperatures above 25°C, the average glucose 60-min and 120-min levels were increased. The relative risk for abnormal glucose values at 60 min, when the environmental temperature increased over 25°C, was 2.2 (1.5-3.3). CONCLUSIONS: GDM prevalence in Greece presents seasonal variation, with higher risk during summer due to post glucose load level variations. These variations could be attributed to differences in environmental temperature.
[Mh] Termos MeSH primário: Diabetes Gestacional/epidemiologia
Estações do Ano
Temperatura Ambiente
[Mh] Termos MeSH secundário: Adulto
Glicemia/metabolismo
Diabetes Gestacional/diagnóstico
Diabetes Gestacional/metabolismo
Feminino
Teste de Tolerância a Glucose
Grécia/epidemiologia
Seres Humanos
Razão de Chances
Gravidez
Terceiro Trimestre da Gravidez
Prevalência
Estudos Prospectivos
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Blood Glucose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0730


  4 / 13321 MEDLINE  
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[PMID]:29292366
[Au] Autor:Li N; Zhu Z; Yi G; Li S; Han X
[Ad] Endereço:Eye Center, Zhongshan Hospital of Sun Yat-Sen University, Zhongshan, Guangdong, China (mainland).
[Ti] Título:Valsalva Retinopathy in Twin-Pregnancy: A Case Report and Literature Review.
[So] Source:Am J Case Rep;19:5-9, 2018 Jan 02.
[Is] ISSN:1941-5923
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Valsalva retinopathy is a rare but sight-threatening condition with sudden visual loss. Twin-pregnancy is known as a confirmed risk factor for Valsalva retinopathy. CASE REPORT A 21-year-old twin-pregnant Chinese woman with 31 weeks of gestation complained of a sudden decrease of visual acuity in her right eye for five hours. Based on the patient's medical history, clinical findings, laboratory testing and optical coherence tomography (OCT) imaging studies, Valsalva retinopathy was confirmed. Initially, we managed the patient with Nd: YAG (neodymium-doped yttrium aluminum garnet) laser to puncture the posterior portion of the vitreous. As the laser failed to puncture the posterior hyaloid face due to dense premacular hemorrhages, we switched to conservative treatment. We reviewed the case with the patient 12 weeks after an uneventful vaginal delivery. Her right visual acuity had spontaneously increased to 6/6 with no active medical intervention. CONCLUSIONS Valsalva retinopathy can be caused by twin-pregnancy. Patients with Valsalva retinopathy can be managed conservatively with careful prognosis following failed laser treatment. Ophthalmologists and obstetrician should coordinate properly and pay more attention to Valsalva retinopathic patients with twin-pregnancy.
[Mh] Termos MeSH primário: Complicações na Gravidez
Gravidez de Gêmeos
Cuidado Pré-Natal
Descolamento Retiniano/terapia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Lasers de Estado Sólido/efeitos adversos
Gravidez
Terceiro Trimestre da Gravidez
Cuidado Pré-Natal/métodos
Prognóstico
Descolamento Retiniano/diagnóstico
Tomografia de Coerência Óptica/métodos
Gêmeos
Acuidade Visual
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE


  5 / 13321 MEDLINE  
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[PMID]:29208037
[Au] Autor:Posthumus L; Donker ME
[Ad] Endereço:Spaarne Gasthuis, Spaarnepoort 1, 2134 TM, Hoofddorp, The Netherlands.
[Ti] Título:Uterine rupture in a primigravid patient, an uncommon but severe obstetrical event: a case report.
[So] Source:J Med Case Rep;11(1):339, 2017 Dec 06.
[Is] ISSN:1752-1947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A spontaneous rupture of the unscarred uterus in a primigravid patient is extremely rare and is associated with high perinatal and maternal morbidity and mortality. CASE PRESENTATION: A 34-year-old white primigravid woman, 31 + 3 weeks of gestation, presented with pre-eclampsia and developed a sudden acute abdomen. An emergency laparotomy was performed and a uterine rupture was found as the cause of the event. A stillborn girl was born. CONCLUSION: A rupture of the pregnant uterus should always be considered in a pregnant woman presenting with abdominal pain, even in a primigravid patient.
[Mh] Termos MeSH primário: Número de Gestações
Natimorto
Ruptura Uterina/cirurgia
[Mh] Termos MeSH secundário: Dor Abdominal/etiologia
Adulto
Antibacterianos/uso terapêutico
Bloqueio Atrioventricular
Bacteriemia/tratamento farmacológico
Eletrocardiografia
Feminino
Seres Humanos
Laparotomia
Complicações Pós-Operatórias/tratamento farmacológico
Gravidez
Terceiro Trimestre da Gravidez
Infecções Estafilocócicas/tratamento farmacológico
Staphylococcus aureus
Ruptura Uterina/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-017-1507-9


  6 / 13321 MEDLINE  
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[PMID]:29310411
[Au] Autor:Deng MX; Zou Y
[Ad] Endereço:Department of Radiology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
[Ti] Título:Evaluating a magnetic resonance imaging of the third-trimester abdominal pregnancy: What the radiologist needs to know.
[So] Source:Medicine (Baltimore);96(48):e8986, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: A 33-week abdominal pregnancy is an extremely rare type of ectopic pregnancy that is potentially life-threatening for the mother and fetus. Reports of using magnetic resonance imaging (MRI) in the third-trimester abdominal pregnancy are very few. PATIENT CONCERNS: A 24-year-old woman (gravida 2, para 1, living 0) at 33 weeks' gestation presented to local hospital complaining of vaginal bleeding for 2 months and lower abdominal pain for 2 days. Then, the woman was transferred to our hospital for suspected abdominal pregnancy, which was confirmed at our hospital on ultrasonography and further evaluated in detail on MRI. DIAGNOSES: The woman was diagnosed as having abdominal pregnancy. INTERVENTIONS: The woman was managed surgically, the unviable fetus was removed, and the placenta was left in situ. Then, the woman was managed with fluids, blood transfusion, antibiotics, and systemic methotrexate after surgery. OUTCOMES: At 42 days postoperatively, the affected woman was discharged in a good condition. CONCLUSIONS: By using MRI, we can accurately diagnose an abdominal pregnancy. MRI provides more details than ultrasonography, and explains the possible mechanism of abdominal pregnancy. We advocate using MRI to help surgical planning and improve outcome in cases of abdominal pregnancy.
[Mh] Termos MeSH primário: Imagem por Ressonância Magnética
Gravidez Abdominal/diagnóstico por imagem
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Laparotomia
Gravidez
Terceiro Trimestre da Gravidez
Gravidez Abdominal/cirurgia
Ultrassonografia Pré-Natal
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008986


  7 / 13321 MEDLINE  
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[PMID]:29227591
[Au] Autor:Korneeva KL; Rodriguez RR; Ralchenko SV; Martunovska OV; Frolova AO; Martsenyuk OP; Manzhula LV; Melnyk VT; Shkoropad OY; Obolenska MY
[Ti] Título:Expression of genes, encoding the enzymes of cysteine metabolism in human placenta in the first and third trimesters of uncomplicated pregnancy.
[So] Source:Ukr Biochem J;88(1):88-98, 2016 Jan-Feb.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:The cellular cysteine is highly regulated in a narrow range of concentrations due to its cyto- and neurtoxicity when it is overwhelmed or its deficiency for protein synthesis and other vital metabolic reactions when its amount is restricted. The regulation of cysteine content and its metabolic products, glutathione, taurine and inorganic sulfur compounds, is scarcely explored in human placenta though cysteine metabolism is closely related to the maintenance of redox status and protection from free radical oxidation, elimination of homocysteine and detoxification. These processes are particularly important for placenta which meets substantial changes of oxygen supply during its development, and is the last metabolically active organ between mother and fetus. The abundance of CDO , CSAD , ADO , SUOX, GCLC and GCLM mRNAs was estimated by RT -qPCR and compared with the computationally analyzed microarray gene expression data from GEO , while the level of individual protein ­ by western-blot analysis, both in placental samples from first and third trimesters of uncomplicated pregnancies. The abundance of CDO mRNA is significantly up-regulated at term compared to the first trimester, the level of GCLM and GCLC mRNAs remains almost unchanged while the abundance of other mRNAs reduces to varying degrees. Overall, the changes of gene expression in third trimester in comparison to the first one estimated by RT-qPCR and microarray coincide while the former data are more informative for the limited group of genes. The data provide the basis for further research of these genes expression and phenotype of human placenta in health and disease
[Mh] Termos MeSH primário: Carboxiliases/genética
Cisteína Dioxigenase/genética
Cisteína/metabolismo
Dioxigenases/genética
Glutamato-Cisteína Ligase/genética
Oxirredutases atuantes sobre Doadores de Grupo Enxofre/genética
[Mh] Termos MeSH secundário: Adulto
Carboxiliases/metabolismo
Cisteína Dioxigenase/metabolismo
Dioxigenases/metabolismo
Feminino
Regulação da Expressão Gênica
Glutamato-Cisteína Ligase/metabolismo
Seres Humanos
Redes e Vias Metabólicas/genética
Oxirredutases atuantes sobre Doadores de Grupo Enxofre/metabolismo
Placenta/metabolismo
Gravidez
Primeiro Trimestre da Gravidez
Terceiro Trimestre da Gravidez
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Messenger); EC 1.13.11.- (Dioxygenases); EC 1.13.11.19 (cysteamine dioxygenase); EC 1.13.11.20 (Cysteine Dioxygenase); EC 1.13.11.20 (cysteine dioxygenase, type I, human); EC 1.8.- (Oxidoreductases Acting on Sulfur Group Donors); EC 1.8.3.1 (SUOX protein, human); EC 4.1.1.- (Carboxy-Lyases); EC 4.1.1.29 (sulfoalanine decarboxylase); EC 6.3.2.2 (GCLC protein, human); EC 6.3.2.2 (Glutamate-Cysteine Ligase); EC 6.3.2.2 (glutamate-cysteine ligase modifier subunit, human); K848JZ4886 (Cysteine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.15407/ubj88.01.088


  8 / 13321 MEDLINE  
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[PMID]:27771566
[Au] Autor:Davis EP; Head K; Buss C; Sandman CA
[Ad] Endereço:Department of Psychology, University of Denver, Denver, CO, 80210, United States; Women and Children's Health and Well-Being Project, Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, California, 92868, United States. Electronic address: elysia.davis@du.edu.
[Ti] Título:Prenatal maternal cortisol concentrations predict neurodevelopment in middle childhood.
[So] Source:Psychoneuroendocrinology;75:56-63, 2017 Jan.
[Is] ISSN:1873-3360
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Glucocorticoids (cortisol in humans) are the end product of the hypothalamic-pituitary-adrenocortical (HPA) axis and are proposed as a key mechanism for programming fetal brain development. The present prospective longitudinal study evaluates the association between prenatal maternal cortisol concentrations and child neurodevelopment. Participants included a low risk sample of 91 mother-child pairs. Prenatal maternal plasma cortisol concentrations were measured at 19 and 31 gestational weeks. Brain development and cognitive functioning were assessed when children were 6-9 years of age. Structural magnetic resonance imaging scans were acquired and cortical thickness was determined. Child cognitive functioning was evaluated using standardized measures (Wechsler Intelligence Scale for Children IV and Expressive Vocabulary Test, Second Edition). Higher maternal cortisol concentrations during the third trimester were associated with greater child cortical thickness primarily in frontal regions. No significant associations were observed between prenatal maternal cortisol concentrations and child cortical thinning. Elevated third trimester maternal cortisol additionally was associated with enhanced child cognitive performance. Findings in this normative sample of typically developing children suggest that elevated maternal cortisol during late gestation exert lasting benefits for brain development and cognitive functioning 6-9 years later. The benefits of fetal exposure to higher maternal cortisol during the third trimester for child neurodevelopment are consistent with the role cortisol plays in maturation of the human fetus. It is plausible that more extreme elevations in maternal cortisol concentrations late in gestation, as well as exposure to pharmacological levels of synthetic glucocorticoids, may have neurotoxic effects on the developing fetal brain.
[Mh] Termos MeSH primário: Córtex Cerebral/anatomia & histologia
Desenvolvimento Infantil/fisiologia
Cognição/fisiologia
Hidrocortisona/metabolismo
Inteligência/fisiologia
Gravidez/metabolismo
[Mh] Termos MeSH secundário: Córtex Cerebral/diagnóstico por imagem
Córtex Cerebral/crescimento & desenvolvimento
Criança
Feminino
Seres Humanos
Estudos Longitudinais
Imagem por Ressonância Magnética
Masculino
Terceiro Trimestre da Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  9 / 13321 MEDLINE  
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[PMID]:28980891
[Au] Autor:Kang Y; Dang S; Zeng L; Wang D; Li Q; Wang J; Ouzhu L; Yan H
[Ad] Endereço:1School of Public Health,Xi'an Jiaotong University Health Science Center,Xi'an,Shaanxi, 710061,People's Republic of China.
[Ti] Título:Multi-micronutrient supplementation during pregnancy for prevention of maternal anaemia and adverse birth outcomes in a high-altitude area: a prospective cohort study in rural Tibet of China.
[So] Source:Br J Nutr;118(6):431-440, 2017 Sep.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Anaemia during pregnancy, characterised by Hb <110 g/l, is a specific risk factor for adverse maternal and perinatal outcomes in developing countries. The objective of this study was to determine the effectiveness of daily antenatal supplementation with multiple micronutrients (MMN) compared with folic acid (FA) on the occurrence of anaemia among pregnant women and their infants' health in a high-altitude area. A prospective cohort study was carried out in two rural counties in Tibet from 2007 to 2012. A total of 1149 eligible pregnant women were allocated daily supplementation with FA in one county and MMN containing a recommended allowance of twenty-three vitamins and minerals in another county starting ≤24 weeks of gestation and continuing until delivery. Compared with the FA group, prenatal supplementation with MMN was significantly associated with reduced odds of anaemia in the third trimester. This was demonstrated in the primary outcome, with an adjusted OR (AOR) of 0·63; 95 % CI 0·45, 0·88 and P=0·007 and also reduced odds of preterm delivery (AOR: 0·31; 95 % CI 0·15, 0·61; P=0·001). There was no difference between MMN and FA groups in mean birth weight (adjusted mean difference: 36·78; 95 % CI -19·42, 92·98 g; P=0·200), whereas MMN supplementation significantly reduced the odds of low-birth weight (LBW) babies (AOR: 0·58; 95 % CI 0·36, 0·91; P=0·019). In conclusion, the antenatal MMN supplementation in rural Tibet is associated with a reduction of maternal anaemia in the third trimester, and may potentially decrease the risk of preterm delivery and LBW babies.
[Mh] Termos MeSH primário: Anemia Ferropriva/prevenção & controle
Suplementos Nutricionais
Micronutrientes/administração & dosagem
Resultado da Gravidez
Nascimento Prematuro/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Peso ao Nascer
China
Feminino
Ácido Fólico/administração & dosagem
Seguimentos
Seres Humanos
Recém-Nascido de Baixo Peso/crescimento & desenvolvimento
Modelos Logísticos
Gravidez
Terceiro Trimestre da Gravidez
Estudos Prospectivos
Fatores de Risco
População Rural
Fatores Socioeconômicos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Micronutrients); 935E97BOY8 (Folic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1017/S000711451700229X


  10 / 13321 MEDLINE  
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[PMID]:28973345
[Au] Autor:Cohn BA; Cirillo PM; Hopper BR; Siiteri PK
[Ad] Endereço:Child Health and Development Studies, Public Health Institute, Berkeley, California 94709.
[Ti] Título:Third Trimester Estrogens and Maternal Breast Cancer: Prospective Evidence.
[So] Source:J Clin Endocrinol Metab;102(10):3739-3748, 2017 Oct 01.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Context: Full-term pregnancy is associated with a transient increase and life-time decrease in maternal breast cancer risk. Estrone (E1), estradiol (E2), and estriol (E3) are in high concentration during the third trimester. E1 and E2 metabolism produces carcinogenic intermediaries, and E3 metabolism does not. Objective: We tested the hypothesis that higher E3 in pregnancy is protective while higher E1 plus E2 increases risk. Design: Prospective case-cohort study (n = 620; 204 cases) nested in a 38-year follow-up of 15,528 pregnant women in the Child Health and Development Studies. We measured E1, E2, and E3 in archived third trimester serum and estimated associations with breast cancer. Setting: Northern California Kaiser members receiving obstetric care from 1959 to 1967. Main Outcome Measure: Breast cancer diagnosed through 1997. Results: Doubling of E1+E2 was associated with greater risk [hazard ratio (HR), 1.7; 95% confidence interval (CI), 1.2 to 2.4]. In contrast, doubling of E3 or the E3/E1+E2 ratio was associated with protection (HR, 0.7; 95% CI, 0.5 to 1.0; HR, 0.6; 95% CI, 0.4 to 0.8, respectively). Associations were stronger for diagnoses within 15 years after delivery compared with 16 to 38 years (Pinteraction = 0.0002) for gravidas >27 years at delivery vs ≤27 (Pinteraction = 0.01) and for primiparas vs multiparas (Pinteraction = 0.02). Conclusions: Relatively high third trimester E3 levels might protect parous women from breast cancer and E1 and E2 might enhance the risk. If findings are confirmed, third trimester pregnancy estrogens could help explain how parity affects breast cancer.
[Mh] Termos MeSH primário: Neoplasias da Mama/etiologia
Estrogênios/sangue
Mães
Terceiro Trimestre da Gravidez/sangue
[Mh] Termos MeSH secundário: Adulto
Neoplasias da Mama/sangue
Neoplasias da Mama/epidemiologia
Estudos de Casos e Controles
Feminino
Seres Humanos
Idade Materna
Mães/estatística & dados numéricos
Paridade/fisiologia
Gravidez
Fatores de Risco
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estrogens)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2016-3476



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