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[PMID]:28407856
[Au] Autor:Colazo MG; López Helguera I; Behrouzi A; Ambrose DJ; Mapletoft RJ
[Ad] Endereço:Livestock Research and Extension Branch, Alberta Agriculture and Forestry, Edmonton, AB, Canada. Electronic address: marcos.colazo@gov.ab.ca.
[Ti] Título:Relationship between circulating progesterone at timed-AI and fertility in dairy cows subjected to GnRH-based protocols.
[So] Source:Theriogenology;94:15-20, 2017 May.
[Is] ISSN:1879-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objectives of this retrospective study were: 1) to investigate the effect of plasma progesterone (P4) concentrations at the time of timed-AI (TAI) on fertility, and 2) to examine risk factors associated with plasma P4 concentrations that impair fertility in lactating dairy cows subjected to GnRH-based protocols. Data from 872 lactating Holstein cows that had, or had not been presynchronized prior to a 7-day GnRH-based TAI protocol were examined. However, data from only those cows (n = 697; 79.9%) that ovulated after second GnRH were analyzed. Plasma P4 concentrations were determined using a solid-phase radioimmunoassay. Transrectal ultrasonography was used to determine cyclicity at first GnRH treatment, ovulation after first and second GnRH treatments, and pregnancy status at 32 and 60 d after TAI. Parity, days in milk (DIM) and BCS were also recorded. Plasma P4 concentrations at TAI ranged from 0.0 to 9.94 ng/mL (overall mean ± SEM, 0.32 ± 0.02 ng/mL) and 41 (5.9%) cows had P4 ≥ 1.0 ng/mL at TAI. The percentage of cows diagnosed pregnant at 32 and 60 d after TAI was 45.1 and 41.6%, respectively, and pregnancy loss from 32 to 60 d after TAI was 7.6%. Plasma P4 concentrations at TAI affected (P < 0.01) P/AI at 32 and 60 d, but did not affect (P > 0.1) pregnancy loss. No cows with plasma P4 concentrations >0.80 ng/mL became pregnant. However, ROC curve analysis revealed that the optimal P4 threshold at TAI for P/AI at 32 d was ≤0.50 ng/mL, with a sensitivity and specificity of 94.9 and 20.9, respectively. The percentage of cows with plasma P4 concentrations >0.50 ng/mL was 15.8% (110/697). Furthermore, a significant (P < 0.05) quadratic relationship between plasma P4 concentrations at TAI and P/AI at 32 d was observed. The maximum predicted probability of pregnancy was 0.54 at a P4 concentration of 0.26 ng/mL. Based on the odds ratios (OR), cows with P4 ≤ 6.2 ng/mL at PGF were 2.3 times less likely to have P4 > 0.50 ng/mL at TAI compared to cows with P4 > 6.2 ng/mL (OR = 0.44; 95% CI = 0.27 to 0.71; P < 0.01). Also, cyclic cows subjected to presynchronization were less likely to undergo luteal regression than non-presynchronized or acyclic cows (OR = 5.3; 95% CI = 1.77 to 16.27; P < 0.01). In summary, plasma P4 concentrations >0.50 ng/mL at TAI resulted in significantly reduced fertility. As elevated plasma P4 concentrations at TAI were more frequent in cows with lower P4 at PGF or those subjected to presynchronization, both groups are most likely to benefit from an additional PGF treatment prior to TAI.
[Mh] Termos MeSH primário: Bovinos/fisiologia
Inseminação Artificial/veterinária
Progesterona/sangue
[Mh] Termos MeSH secundário: Aborto Animal/epidemiologia
Animais
Sincronização do Estro
Feminino
Fertilidade
Hormônio Liberador de Gonadotropina/uso terapêutico
Inseminação Artificial/métodos
Luteólise
Gravidez
Taxa de Gravidez
Curva ROC
Estudos Retrospectivos
Fatores de Risco
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
33515-09-2 (Gonadotropin-Releasing Hormone); 4G7DS2Q64Y (Progesterone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE


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[PMID]:28244343
[Au] Autor:Liu TC; Ho CY; Chan JP
[Ad] Endereço:Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University , No. 145, Xingda Road, South District, Taichung City 40227, , Taiwan (R. O. C.).
[Ti] Título:Effect of two low doses of prostaglandin F on luteolysis in dairy cows.
[So] Source:Acta Vet Hung;65(1):105-114, 2017 03.
[Is] ISSN:0236-6290
[Cp] País de publicação:Hungary
[La] Idioma:eng
[Ab] Resumo:In this preliminary study, we determined the effect of a modified method involving the administration of two low doses of prostaglandin F (PGF ) at an interval of 24 h on luteolysis in dairy cows, and compared it with the standard single-dose method. Twenty-six cows were assigned to three groups treated with two low doses (TLD group, n = 10), one standard dose (SD group, n = 10), and one low dose (OLD group, n = 6) on day 9 to 10 of the oestrous cycle (day 0 = the day of PGF administration). Their serum progesterone (P4) levels and corpus luteum (CL) sizes were measured daily from day 0 to 4 to assess CL regression. The results indicated that the proportion of complete luteolysis, indicating a P4 value ≤ 1 ng/mL on day 3, was higher in the TLD group (100.0%) than in the SD (60.0%) and OLD (66.7%) groups. Ultrasonically detected changes in the CL area correlated with the shifts in the P4 values in both the TLD and the SD groups. The remaining CL area was significantly smaller in the TLD group (17.8% ± 3.3%) than in the SD or OLD group on day 4. Thus, we concluded that the proportion of luteolysis in cows was increased with two low doses of PGF as compared to a single PGF dose, indicating the necessity of the second dose of PGF . However, further studies with larger sample sizes in the field are required.
[Mh] Termos MeSH primário: Bovinos/fisiologia
Dinoprosta/farmacologia
Luteólise/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Dinoprosta/administração & dosagem
Relação Dose-Resposta a Droga
Esquema de Medicação
Feminino
Ovulação/metabolismo
Progesterona/sangue
Progesterona/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
4G7DS2Q64Y (Progesterone); B7IN85G1HY (Dinoprost)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170706
[Lr] Data última revisão:
170706
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE
[do] DOI:10.1556/004.2017.011


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[PMID]:28237341
[Au] Autor:Romano JE; Alkar A; Amstalden M
[Ad] Endereço:Large Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX 77843-4475, USA. Electronic address: jromano@cvm.tamu.edu.
[Ti] Título:Onset of luteolytic action of exogenous prostaglandinF-2α during estrous cycle in goats.
[So] Source:Theriogenology;92:45-50, 2017 Apr 01.
[Is] ISSN:1879-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objectives of these two experiments were to determine the day of onset of luteolysis after exogenous PGF-2α administration during the estrous cycle and the fertility of this synchronized estrus in goats. In the first experiment, during the breeding season, 48 Nubian does were estrous synchronized, using intravaginal sponges impregnated with a progestin, and estrus was detected by vasectomized bucks. The does were divided at random into three groups of 16 does each to be treated at days 2, 3, and 4 of the estrous cycle (estrus = day 0). Then, at each day of injection, the does were again randomly divided to receive a single dose of natural prostaglandin F-2α im (PGF-2α; 5 mg/doe; treatment [TRE] group) or sterile saline solution (control [CON] group; 1 mL/doe). Finally, the following groups were originated: TRE-2, CON-2, TRE-3, CON-3, TRE-4, and CON-4. The overall estrus response after treatment with PGF-2α (TRE group, 70.8%) was higher than saline (CON group, 12.5%, P ≤ 0.001). Estrus response for TRE-2, CON-2, TRE-3, CON-3, TRE-4, and CON-4 was 25% (2 of 8), 12.5% (1 of 8), 87.5% (7 of 8), 12.5% (1 of 8), 100% (8 of 8), and 0% (0 of 8) for the same groups, respectively. Estrus response was different between day 2 and days 3 and 4 (P ≤ 0.04) and not between day 3 and day 4 (P ≥ 0.05). In the second experiment, 15 multiparous Boer does were estrous synchronized with control internal drug release (CIDR, 300 mg progesterone = P ) and PGF-2 and randomly divided to receive one single dose of PGF-2α im at days 2, 3 or 4, after synchronized estrus (n = 5 at each day). The does were detected twice a day for estrus, and blood was collected daily for P determination for 11 days after the synchronized estrus. Each doe in estrus was bred by hand mating to a proven male. All the does with a functional corpus/corpora luteum/lutea (CL; ≥1.0 ng/mL of P ) responded to PGF-2α with a drop in P levels that either lasted only 24 h for the does that did not show estrus (0.27 ± 0.10 ng/mL; n = 4) or persisted longer in all the does that showed estrus (0.22 ± 0.18 ng/mL; n = 10; P = 0.47). Estrus response for days 2, 3, and 4 was 20% (1 of 5), 80% (4 of 5), and 100% (5 of 5), respectively (P = 0.05). The conception rate was 100%, 100%, and 80% for the same days of administration, respectively (P = 0.64). It was concluded that luteolytic action of PGF-2α begins at day 3 of the estrous cycle by inducing an ovulatory and fertile estrus in goats.
[Mh] Termos MeSH primário: Dinoprosta/farmacologia
Ciclo Estral/fisiologia
Cabras/fisiologia
Luteólise/efeitos dos fármacos
Ocitócicos/farmacologia
[Mh] Termos MeSH secundário: Animais
Dinoprosta/administração & dosagem
Esquema de Medicação
Feminino
Luteólise/fisiologia
Ocitócicos/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Oxytocics); B7IN85G1HY (Dinoprost)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170227
[St] Status:MEDLINE


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[PMID]:28098892
[Au] Autor:Fang L; Gu C; Liu X; Xie J; Hou Z; Tian M; Yin J; Li A; Li Y
[Ad] Endereço:Tianjin State Key Laboratory of Modern Chinese Medicine, School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P.R. China.
[Ti] Título:Metabolomics study on primary dysmenorrhea patients during the luteal regression stage based on ultra performance liquid chromatography coupled with quadrupole­time­of­flight mass spectrometry.
[So] Source:Mol Med Rep;15(3):1043-1050, 2017 Mar.
[Is] ISSN:1791-3004
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Primary dysmenorrhea (PD) is a common gynecological disorder which, while not life­threatening, severely affects the quality of life of women. Most patients with PD suffer ovarian hormone imbalances caused by uterine contraction, which results in dysmenorrhea. PD patients may also suffer from increases in estrogen levels caused by increased levels of prostaglandin synthesis and release during luteal regression and early menstruation. Although PD pathogenesis has been previously reported on, these studies only examined the menstrual period and neglected the importance of the luteal regression stage. Therefore, the present study used urine metabolomics to examine changes in endogenous substances and detect urine biomarkers for PD during luteal regression. Ultra performance liquid chromatography coupled with quadrupole­time­of­flight mass spectrometry was used to create metabolomic profiles for 36 patients with PD and 27 healthy controls. Principal component analysis and partial least squares discriminate analysis were used to investigate the metabolic alterations associated with PD. Ten biomarkers for PD were identified, including ornithine, dihydrocortisol, histidine, citrulline, sphinganine, phytosphingosine, progesterone, 17­hydroxyprogesterone, androstenedione, and 15­keto­prostaglandin F2α. The specificity and sensitivity of these biomarkers was assessed based on the area under the curve of receiver operator characteristic curves, which can be used to distinguish patients with PD from healthy controls. These results provide novel targets for the treatment of PD.
[Mh] Termos MeSH primário: Dismenorreia/metabolismo
Luteólise/metabolismo
Metaboloma
Metabolômica
[Mh] Termos MeSH secundário: Biomarcadores
Estudos de Casos e Controles
Cromatografia Líquida de Alta Pressão
Dismenorreia/urina
Feminino
Seres Humanos
Redes e Vias Metabólicas
Metabolômica/métodos
Curva ROC
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE
[do] DOI:10.3892/mmr.2017.6116


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[PMID]:28043355
[Au] Autor:Baez GM; Trevisol E; Barletta RV; Cardoso BO; Ricci A; Guenther JN; Cummings NE; Wiltbank MC
[Ad] Endereço:Department of Dairy Science, University of Wisconsin-Madison, Madison, Wisconsin, USA; Department of Agricultural and Animal Sciences, Universidad Francisco de Paula Santander, Cúcuta, Colombia.
[Ti] Título:Proposal of a new model for CL regression or maintenance during pregnancy on the basis of timing of regression of contralateral, accessory CL in pregnant cows.
[So] Source:Theriogenology;89:214-225, 2017 Feb.
[Is] ISSN:1879-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In bovine pregnancy, regression or maintenance of the corpus luteum (CL) is mediated through local communication pathways between embryo, uterus, and ovary with Days 16 to 25 of pregnancy generally recognized as the pivotal period determining either luteolysis or prevention of luteolysis. To evaluate this concept, accessory CL was generated by treating Holstein lactating dairy cows (n = 718) with GnRH on Day 5 of the first follicular wave to produce an accessory CL on the ovary either contralateral or ipsilateral to the gravid horn. In pregnant cows, 66.2% (86/130) of contralateral CL regressed by Day 75 of pregnancy, whereas few ipsilateral accessory CL regressed (11.9%; 8/67), on the basis of similar criteria (P < 0.0001). As hypothesized, some contralateral CL regressions (22/86 = 25.6%) happened on Days 19 to 25 of pregnancy. However, most contralateral CL regressions (64/86 = 74.4%) happened later than expected, from Days 33 to 60 of pregnancy. Later contralateral CL regression was more common in primiparous (84.3%) than multiparous (60.0%; P = 0.02) cows. Early accessory contralateral CL regression (Days 19-25) may be related to lack of exposure of the contralateral horn to interferon tau from the elongating embryo because pregnant cows without early accessory CL regression had a smaller uterine volume than nonpregnant cows or pregnant cows that had early accessory CL regression (128.4 ± 3.9 vs. 147.0 ± 3.8 vs. 143.6 ± 10.9 mm , respectively; P = 0.003). These results indicate that there is a second distinct period for CL protection during bovine pregnancy from Days 30 to 60 and implicate local and not systemic pathways in occurrence or prevention of luteolysis during both the early (≤25 days) and later (≥33 days) critical periods since accessory contralateral CL regressed whereas the accessory ipsilateral CL of pregnancy remained.
[Mh] Termos MeSH primário: Corpo Lúteo/metabolismo
Luteólise/fisiologia
Modelos Biológicos
[Mh] Termos MeSH secundário: Animais
Bovinos
Corpo Lúteo/diagnóstico por imagem
Sincronização do Estro
Feminino
Hormônio Liberador de Gonadotropina/farmacologia
Inseminação Artificial/veterinária
Interferon Tipo I/metabolismo
Gravidez
Proteínas da Gravidez/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interferon Type I); 0 (Pregnancy Proteins); 0 (trophoblastin); 33515-09-2 (Gonadotropin-Releasing Hormone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170104
[St] Status:MEDLINE


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[PMID]:28019139
[Au] Autor:Lawrenz B; Ruiz F; Engelmann N; Fatemi HM
[Ad] Endereço:a IVI Middle East Fertility Center , Marina Village, Abu Dhabi , UAE.
[Ti] Título:Individual luteolysis post GnRH-agonist-trigger in GnRH-antagonist protocols.
[So] Source:Gynecol Endocrinol;33(4):261-264, 2017 Apr.
[Is] ISSN:1473-0766
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Over the past few years, the use of Gonadotropin-releasing-hormone (GnRH)-agonist for final oocyte maturation in GnRH-antagonist-protocols in stimulated IVF/ICSI cycles has gained worldwide acceptance, as this approach reduces significantly the risk for development of ovarian hyperstimulation syndrome (OHSS). Final oocyte maturation with GnRH-agonist leads to sever luteolysis, which cannot be counterbalanced using standard luteal phase support with purely progesterone (P4) application and therefore administration of hCG or high doses of P4 is considered to be essential to prevent/counteract luteolysis. However, lately publications indicate, that luteolysis is not always complete after GnRH-agonist for trigger. This case-series evaluates the degree of luteolysis in high-responder-patients, who received GnRH-agonist for final oocyte maturation. Assessment of estradiol (E2)- and P4-levels 48 h after oocyte-pick-up (OPU) procedure demonstrate clearly, that luteolysis after GnRH-agonist trigger is individual-specific, even in high-responder patients with the same number of oocytes. Hence, individualization of luteal phase support with the focus on avoiding unnecessary administration of hCG, bearing the risk for development of OHSS, a new concept of luteal coasting needs to be developed, based on severity of luteolysis following luteal coasting.
[Mh] Termos MeSH primário: Fertilização In Vitro/métodos
Hormônio Liberador de Gonadotropina/agonistas
Hormônio Liberador de Gonadotropina/antagonistas & inibidores
Luteólise/efeitos dos fármacos
Indução da Ovulação/métodos
Injeções de Esperma Intracitoplásmicas/métodos
[Mh] Termos MeSH secundário: Adulto
Estradiol/sangue
Feminino
Antagonistas de Hormônios/uso terapêutico
Seres Humanos
Recuperação de Oócitos
Gravidez
Taxa de Gravidez
Progesterona/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hormone Antagonists); 33515-09-2 (Gonadotropin-Releasing Hormone); 4G7DS2Q64Y (Progesterone); 4TI98Z838E (Estradiol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161227
[St] Status:MEDLINE
[do] DOI:10.1080/09513590.2016.1266325


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[PMID]:27889121
[Au] Autor:Sauls JA; Voelz BE; Hill SL; Mendonça LG; Stevenson JS
[Ad] Endereço:Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506-0201.
[Ti] Título:Increasing estrus expression in the lactating dairy cow.
[So] Source:J Dairy Sci;100(1):807-820, 2017 Jan.
[Is] ISSN:1525-3198
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Using an activity monitoring system (AMS) equipped with an accelerometer, 2 experiments were conducted to test the hypotheses that (1) enhancing progesterone before inducing luteolysis or (2) exposing cows to estradiol cypionate (ECP) or testosterone propionate (TP) after luteolysis would increase occurrence and intensity of estrus. Our goal was to determine if more cows could be detected in estrus by an AMS compared with other estrus-detection aids. In experiment 1, cows (n=154) were fitted with both an AMS collar and a pressure-sensitive, rump-mounted device (HeatWatch; HW) and assigned to 3 treatments: (1) no CL + progesterone insert (CIDR) for 5d, (2) CL only, or (3) CL + 2 CIDR inserts for 5d to achieve a range in concentrations of progesterone. Prostaglandin F was administered to all cows upon CIDR insert removal or its equivalent. Progesterone concentration up to 72h posttreatment was greatest in CL + 2 CIDR, followed by CL only, and no CL + CIDR cows. Estrus occurred 14 to 28h earlier in no CL + CIDR compared with CL-bearing cows. Estrus intensity was greater for CL + 2 CIDR than for CL-only cows. The AMS and HW detected 70 and 59% of cows defined to be in estrus, respectively. In experiment 2, cows (n=203) were equipped with both an AMS and a friction-activated, rump-mounted patch (Estrotect patch) and assigned to receive 1mg of ECP, 2mg of TP, or control 24h after PGF . Concentrations of estradiol 24 and 48h after treatment were greater in ECP cows compared with controls. Estrus expression detected by AMS or patches in cows defined to be in estrus tended to be greater or was greater for ECP compared with controls, respectively. Compared with controls and in response to TP or ECP, estrus occurred 8 to 18h earlier and was of greater intensity for ECP cows, respectively. The AMS and patches determined 73 and 76% of cows defined to be in estrus, respectively. Of cows exposed to the AMS, HW, or patches, 70, 61, and 75%, respectively, were detected in estrus and more than 93% of these subsequently ovulated. In contrast, of the residual cows not detected in estrus, 62 to 77% ovulated in the absence of detected estrus. Only ECP was successful in inducing more expression and intensity of estrus, and proportions of cows detected in estrus exceeded 80%. Given the large proportion of cows equipped with AMS collars ovulating in the absence of estrus, further research is warranted to determine if more pregnancies can be achieved by inseminating those cows not detected in estrus at an appropriate time when PGF is administered to induce luteolysis.
[Mh] Termos MeSH primário: Estro/efeitos dos fármacos
Lactação
[Mh] Termos MeSH secundário: Animais
Bovinos
Dinoprosta/farmacologia
Estradiol/análogos & derivados
Estradiol/farmacologia
Detecção do Estro
Feminino
Luteólise/efeitos dos fármacos
Ovulação/efeitos dos fármacos
Progesterona/metabolismo
Propionato de Testosterona/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
4G7DS2Q64Y (Progesterone); 4TI98Z838E (Estradiol); 7E1DV054LO (estradiol 17 beta-cypionate); B7IN85G1HY (Dinoprost); WI93Z9138A (Testosterone Propionate)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161128
[St] Status:MEDLINE


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[PMID]:27671290
[Au] Autor:Kaya S; Kaçar C; Polat B; Çolak A; Kaya D; Gürcan IS; Bollwein H; Aslan S
[Ad] Endereço:Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, University of Kafkas, Kars, Turkey. Electronic address: semra-kafkas@hotmail.com.
[Ti] Título:Association of luteal blood flow with follicular size, serum estrogen and progesterone concentrations, and the inducibility of luteolysis by PGF in dairy cows.
[So] Source:Theriogenology;87:167-172, 2017 Jan 01.
[Is] ISSN:1879-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to investigate the compatibility of the visual evaluation result of the blood flow characteristics and the blood flow measurements of the CL and the predictability of the responses given by corpora lutea with varying levels of blood flow to an induction of luteolysis by a PGF injection and to determine the possibility of increase in serum estrogen and progesterone concentrations in parallel with increased luteal blood flow (LBF). The cows, bearing a CL (n = 60; postpartum 35 days), were injected with PGF and were monitored for signs of estrous following the first injection. The cows, which did not show estrous signs, were examined for the presence of a CL on Day 14, whereas those that showed signs of estrous were examined on Day 10 following the onset of estrous. The level of LBF was visually graded as + (low; GI), ++ (medium; GII), +++ (high; GIII), and ++++ (very high; GIV). Immediately after the examination of LBFs, a second intramuscular injection of PGF was injected. In the cows, which were determined to be in estrous, the diameter of the Graafian follicles was measured by B-mode ultrasonography. Subsequently, these animals were artificially inseminated. The animals, which did not show estrous after the second injection, were examined as previously described and monitored for signs of estrous. A strong correlation (r = 0.654; P < 0.001) was determined to exist between the results of the visual examination of the images and the results obtained for the LBF area with the use of the Pixel Flux software. GIII (0.83 ± 0.15 cm ) and GIV (1.03 ± 0.48 cm ) were found to differ from GI (0.47 ± 0.23 cm ) and GII (0.51 ± 0.12 cm ) for the size of the LBF (P < 0.001). Serum progesterone levels in groups (GI, GII, GIII, and GIV) were determined to be 4.44 ± 2.42 ng/mL, 6.03 ± 2.37 ng/mL, 7.01 ± 2.94 ng/mL, and 7.17 ± 1.69 ng/mL, respectively. The comparative evaluation of the study groups showed that the groups did not statistically differ for the period between PGF injection and the onset of estrous, mean Graafian follicle size and estrogen levels. No direct correlation existed between these reproductive parameters and LBF.
[Mh] Termos MeSH primário: Velocidade do Fluxo Sanguíneo/veterinária
Bovinos
Corpo Lúteo/irrigação sanguínea
Dinoprosta/farmacologia
Estrogênios/sangue
Progesterona/sangue
[Mh] Termos MeSH secundário: Animais
Feminino
Luteólise/efeitos dos fármacos
Ocitócicos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estrogens); 0 (Oxytocics); 4G7DS2Q64Y (Progesterone); B7IN85G1HY (Dinoprost)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160928
[St] Status:MEDLINE


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[PMID]:27658124
[Au] Autor:Chang J; Frandsen S; Gadsby JE
[Ad] Endereço:Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
[Ti] Título:Prostaglandin synthesis by the porcine corpus luteum: effect of tumor necrosis factor-α.
[So] Source:Domest Anim Endocrinol;58:53-62, 2017 Jan.
[Is] ISSN:1879-0054
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The porcine corpus luteum (CL) displays delayed sensitivity to PGF-2α (luteolytic sensitivity, [LS]) until days 12 to 13 of cycle. The control of LS is unknown, but it is temporally associated with macrophage (which secrete tumor necrosis factor-α; TNF-α) infiltration into the CL. Other studies showed that TNF-α induces LS in vitro and that prostaglandins (PGs) may be involved in this mechanism. In experiment 1, PGF-2α and PGE secretion by luteal cells (LCs) was measured on days 4 to 14 of the estrous cycle, and the expression of PTGFS/AKR1B1 and PTGES/mPGES-1, determined by Western blot, before (day 7) vs after (day 13) the onset of LS. Results showed that the PGF-2α:PGE ratio increased significantly (P < 0.05) from day 4 to 13-14, and PTGFS/AKR1B1 and PTGES/mPGES-1 were significantly increased (P < 0.05) on day 13 (vs day 7). In experiment 2, LCs were collected from porcine CL at early (∼days 4-6) or mid (∼days 7-12) stages of the estrous cycle and cultured with 0, 0.1, 1, or 10 ng/mL TNF-α. Results showed that TNF-α significantly increased (P < 0.05) messenger RNA (mRNA) expression of cyclooxygenase (COX)-2 and mPGES-1 but not AKR1B1. TNF-α had no significant effects on AKR1B1 or mPGES protein abundance. TNF-α significantly increased (P < 0.05) PGE-2 but had no effect on PGF-2α secretion or on the PGF-2α:PGE2 ratio. In conclusion, although TNF-α increased COX2 and mPGES-1 mRNA, and PGE-2 secretion in vitro, it did not increase the PGF-2α:PGE2 ratio. Studies are currently directed toward exploring other pathways (eg, FP receptor signaling) by which TNF-α induces LS in the porcine CL.
[Mh] Termos MeSH primário: Corpo Lúteo/metabolismo
Prostaglandinas/biossíntese
Sus scrofa/metabolismo
Fator de Necrose Tumoral alfa/farmacologia
[Mh] Termos MeSH secundário: Aldeído Redutase/análise
Aldeído Redutase/genética
Animais
Células Cultivadas
Corpo Lúteo/efeitos dos fármacos
Ciclo-Oxigenase 2/genética
Dinoprosta/análise
Dinoprosta/biossíntese
Dinoprosta/farmacologia
Dinoprostona/análise
Dinoprostona/biossíntese
Dinoprostona/secreção
Feminino
Células Lúteas/metabolismo
Luteólise/efeitos dos fármacos
Prostaglandina-E Sintases/análise
Prostaglandina-E Sintases/genética
RNA Mensageiro/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Prostaglandins); 0 (RNA, Messenger); 0 (Tumor Necrosis Factor-alpha); B7IN85G1HY (Dinoprost); EC 1.1.1.21 (Aldehyde Reductase); EC 1.14.99.1 (Cyclooxygenase 2); EC 5.3.99.3 (Prostaglandin-E Synthases); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160923
[St] Status:MEDLINE


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[PMID]:27609083
[Au] Autor:Geppert TC; Meyer AM; Perry GA; Gunn PJ
[Ad] Endereço:1Department of Animal Science,Iowa State University,Ames,IA 50011,USA.
[Ti] Título:Effects of excess metabolizable protein on ovarian function and circulating amino acids of beef cows: 2. Excessive supply in varying concentrations from corn gluten meal.
[So] Source:Animal;11(4):634-642, 2017 Apr.
[Is] ISSN:1751-732X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the dairy industry, excess dietary CP is consistently correlated with decreased conception rates. However, amount of excess CP effects on reproductive function in beef cattle is largely undefined. The objective of this experiment was to determine the effects of excess metabolizable protein (MP) supplementation from a moderately abundant rumen undegradable protein (RUP) source (corn gluten meal: 62% RUP) on ovarian function and circulating amino acid (AA) concentrations in beef cows consuming low quality forage. Non-pregnant, non-lactating beef cows (n=16) were allocated by age, BW and body condition score (BCS) to 1 of 2 isocaloric supplements designed to maintain BW for 60 days. Cows had ad libitum access to corn stalks and were individually offered a corn gluten meal-based supplement daily at 125% (MP125) or 150% (MP150) of National Research Council (NRC) MP requirements. After a 20-day supplement adaptation period, cows were synchronized for ovulation. After 10 days of synchronization, follicular growth was reset with gonadotropin releasing hormone. Daily thereafter, transrectal ultrasonography was performed to diagram ovarian follicular waves, and blood samples were collected for hormone, metabolite and AA analyses. After 7 days of observation of estrus, corpus luteum (CL) size was determined via ultrasound. Data were analyzed using the MIXED procedures of SAS. No differences (P⩾0.21) in BW and BCS existed throughout the study; however, plasma urea N at ovulation was greater (P=0.04) in MP150. Preovulatory ovarian follicle size at dominance, duration of dominance, size at spontaneous luteolysis, length of proestrus and wavelength were not different (P⩾0.11) between treatments. However, ovulatory follicles were larger (P=0.04) and average antral follicle count was greater (P=0.01) in MP150 than MP125. Estradiol concentration and ratio of estradiol to ovulatory follicle volume were not different due to treatment (P⩾0.25). While CL volume 7 days post-estrus was greater (P<0.01) in MP150 than MP125, circulating progesterone 7 days post-estrus and ratio of progesterone to CL volume were not different (P⩾0.21). Total AA were not different (P⩾0.76) at study initiation or completion; however, as a percent of total AA, branched-chain AA at ovulation were greater (P=0.02) in MP150. In conclusion, supplementation of CP at 150% of NRC MP requirements from a moderately undegradable protein source may enhance growth of the ovulatory follicle and subsequent CL compared with MP supplementation at 125% of NRC MP requirements.
[Mh] Termos MeSH primário: Aminoácidos/sangue
Bovinos/fisiologia
Suplementos Nutricionais
Glutens/administração & dosagem
Ovário/fisiologia
Zea mays
[Mh] Termos MeSH secundário: Ração Animal/análise
Animais
Nitrogênio da Ureia Sanguínea
Corpo Lúteo/efeitos dos fármacos
Dieta/veterinária
Estradiol/sangue
Estro/efeitos dos fármacos
Feminino
Hormônio Liberador de Gonadotropina/administração & dosagem
Luteólise
Folículo Ovariano/efeitos dos fármacos
Ovulação/efeitos dos fármacos
Progesterona/sangue
Carne Vermelha
Rúmen/efeitos dos fármacos
Rúmen/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 33515-09-2 (Gonadotropin-Releasing Hormone); 4G7DS2Q64Y (Progesterone); 4TI98Z838E (Estradiol); 8002-80-0 (Glutens)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160910
[St] Status:MEDLINE
[do] DOI:10.1017/S1751731116001890



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