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Pesquisa : G08.852 [Categoria DeCS]
Referências encontradas : 450 [refinar]
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[PMID]:28457668
[Au] Autor:Gonzalez R; Ludwikowski BM
[Ad] Endereço:Auf der Bult Kinderkrankenhaus, Hannover, Germany. Electronic address: ricardo_gonzalez33154@yahoo.com.
[Ti] Título:Re: "Stites J, Bernabé KJ, Galan D, Felsen D, Poppas DP. Urinary continence outcomes following vaginoplasty in patients with congenital adrenal hyperplasia." J Pediatr Urol 2017;13:38.e1-38.e7 and Diamond DA. 'Commentary to "Urinary continence outcome following vaginoplasty in patients with congenital adrenal hyperplasia."' J Pediatr Urol 2017;13:39.
[So] Source:J Pediatr Urol;13(5):535, 2017 10.
[Is] ISSN:1873-4898
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Hiperplasia Suprarrenal Congênita/cirurgia
Diamante
[Mh] Termos MeSH secundário: Feminino
Procedimentos Cirúrgicos em Ginecologia
Seres Humanos
Fenômenos Fisiológicos do Sistema Urinário
Vagina/cirurgia
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
7782-40-3 (Diamond)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:28863222
[Au] Autor:Koratala A; Bhattacharya D; Kazory A
[Ad] Endereço:From the Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville.
[Ti] Título:Chronic Kidney Disease in Pregnancy.
[So] Source:South Med J;110(9):578-585, 2017 Sep.
[Is] ISSN:1541-8243
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:With the increasing prevalence of chronic kidney disease (CKD) worldwide, the number of pregnant women with various degrees of renal dysfunction is expected to increase. There is a bidirectional relation between CKD and pregnancy in which renal dysfunction negatively affects pregnancy outcomes, and the pregnancy can have a deleterious impact on various aspects of kidney disease. It has been shown that even mild renal dysfunction can increase considerably the risk of adverse maternal and fetal outcomes. Moreover, data suggest that a history of recovery from acute kidney injury is associated with adverse pregnancy outcomes. In addition to kidney dysfunction, maternal hypertension and proteinuria predispose women to negative outcomes and are important factors to consider in preconception counseling and the process of risk stratification. In this review, we provide an overview of the physiologic renal changes during pregnancy as well as available data regarding CKD and pregnancy outcomes. We also highlight the important management strategies in women with certain selected renal conditions that are seen commonly during the childbearing years. We call for future research on underexplored areas such as the concept of renal functional reserve to develop a potential clinical tool for prognostication and risk stratification of women at higher risk for complications during pregnancy.
[Mh] Termos MeSH primário: Complicações na Gravidez
Gravidez/fisiologia
Insuficiência Renal Crônica
Fenômenos Fisiológicos do Sistema Urinário
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Testes de Função Renal
Complicações na Gravidez/fisiopatologia
Resultado da Gravidez
Insuficiência Renal Crônica/complicações
Insuficiência Renal Crônica/fisiopatologia
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE
[do] DOI:10.14423/SMJ.0000000000000693


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[PMID]:28444714
[Au] Autor:Badawi JK; Bosch R; Djurhuus JC; Hanna-Mitchell AT
[Ad] Endereço:Department of Urology, University Hospital Mannheim, Medical Faculty of the Ruprechts-Karls-University of Heidelberg, Mannheim, Germany.
[Ti] Título:Is testosterone important in LUT function in men and women? ICI-RS 2015.
[So] Source:Neurourol Urodyn;36(4):859-862, 2017 04.
[Is] ISSN:1520-6777
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIM: This review article is a collaborative report based upon the Authors' presentations and Group discussion on the role of testosterone (T) in the male and female lower urinary tract (LUT) which took place at the 6th International Consultation on Incontinence Research Society's (ICI-RS) annual meeting, in Bristol, UK (September 8-10, 2015). METHODS: It comprises overviews and opinions on both the current state of knowledge of the role of T in LUT function and dysfunction in both sexes. RESULTS: Results from animal studies suggest that T treatment may be beneficial for disorders of the LUT in women including urinary incontinence and pelvic organ prolapse. The need for clinical studies to evaluate the effect of T treatment in peri- and post-menopausal women, taking into account the type of applied androgen, the application form, timing and dosage, is especially emphasized. In males, findings on the impact of T on the male external urethral sphincter underscores that there is still much to learn about its role in male LUT physiology. The important topic of the use of T therapy in the treatment of enuresis in the young, both sexes, is also discussed. The importance of understanding the steroidogenic pathways linking T with estradiol is discussed as being of paramount importance in researching the unique actions of T in the LUT. CONCLUSION: The overall conclusion is that further research into the role of T in LUT function and dysfunction across genders and age groups (young to old) is extremely important. Neurourol. Urodynam. 36:859-862, 2017. © 2017 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Sintomas do Trato Urinário Inferior/fisiopatologia
Testosterona/metabolismo
Fenômenos Fisiológicos do Sistema Urinário/efeitos dos fármacos
Sistema Urinário/efeitos dos fármacos
Sistema Urinário/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Feminino
Seres Humanos
Masculino
Testosterona/administração & dosagem
Testosterona/sangue
Agentes Urológicos/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Urological Agents); 3XMK78S47O (Testosterone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1002/nau.23041


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[PMID]:27725321
[Au] Autor:Gómez-Blanco JC; Martínez-Reina J; Cruz D; Blas Pagador J; Sánchez-Margallo FM; Soria F
[Ad] Endereço:Unidad de Bioingeniería y Tecnologías Sanitarias. Centro de Cirugía de Mínima Invasión Jesús Usón. Cáceres.
[Ti] Título:[Application of fluid mechanics and simulation: urinary tract and ureteral catheters.]
[Ti] Título:Aplicación de la mecánica de fluidos y la simulación: tracto urinario y catéteres ureterales..
[So] Source:Arch Esp Urol;69(8):451-461, 2016 Oct.
[Is] ISSN:0004-0614
[Cp] País de publicação:Spain
[La] Idioma:spa
[Ab] Resumo:The mechanics of urine during its transport from the renal pelvis to the bladder is of great interest for urologists. The knowledge of the different physical variables and their interrelationship, both in physiologic movements and pathologies, will help a better diagnosis and treatment. The objective of this chapter is to show the physics principles and their most relevant basic relations in urine transport, and to bring them over the clinical world. For that, we explain the movement of urine during peristalsis, ureteral obstruction and in a ureter with a stent. This explanation is based in two tools used in bioengineering: the theoretical analysis through the Theory of concontinuous media and Ffluid mechanics and computational simulation that offers a practical solution for each scenario. Moreover, we review other contributions of bioengineering to the field of Urology, such as physical simulation or additive and subtractive manufacturing techniques. Finally, we list the current limitations for these tools and the technological development lines with more future projection. CONCLUSIONS: In this chapter we aim to help urologists to understand some important concepts of bioengineering, promoting multidisciplinary cooperation to offer complementary tools that help in diagnosis and treatment of diseases.
[Mh] Termos MeSH primário: Simulação por Computador
Hidrodinâmica
Cateteres Urinários
Fenômenos Fisiológicos do Sistema Urinário
[Mh] Termos MeSH secundário: Seres Humanos
Manequins
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170214
[Lr] Data última revisão:
170214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161012
[St] Status:MEDLINE


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[PMID]:27534993
[Au] Autor:Cheng CL; de Groat WC
[Ad] Endereço:Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China; and cheng20011@gmail.com.
[Ti] Título:Effect of orchiectomy and testosterone replacement on lower urinary tract function in anesthetized rats.
[So] Source:Am J Physiol Renal Physiol;311(5):F864-F870, 2016 Nov 01.
[Is] ISSN:1522-1466
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lower urinary tract (LUT) symptoms (LUTS), including frequency, urgency, incomplete voiding, and slow stream, are common in both men and women with advancing age. The most common cause for LUTS in aging men is benign prostatic hyperplasia. Some studies have also revealed an inverse association of serum testosterone levels with LUTS; however, the underlying mechanisms by which gonadal hormones affect the LUT have not been clarified. In the present study, we examined the effect of orchiectomy and testosterone replacement on LUT function in adult male Sprague-Dawley rats. Six weeks after bilateral orchiectomy or sham operations and 3 wk after injection of long-acting testosterone undecanoate (100 mg/kg im), transvesical cystometry and external urethral sphincter electromyogram (EUS EMG) recordings were performed under urethane anesthesia. The micturition reflex was elicited in both sham and orchiectomized animals. In orchiectomized rats, volume threshold for inducing micturition decreased by 47.6%; however, contraction amplitude, duration, and voiding efficiency were similar in sham and orchiectomized rats. The active period during EUS EMG bursting was lengthened during micturition in orchiectomized animals. Testosterone treatment, which normalized plasma testosterone levels, reversed these changes but also increased the duration of EUS EMG bursting. Orchiectomy also reduced mean voiding flow rate estimated from the duration of EUS EMG bursting, an effect that was not reversed by testosterone. The results indicate that orchiectomy affects both the active and passive properties of the bladder and urethra, and that many, but not all, of the changes can be reversed by testosterone.
[Mh] Termos MeSH primário: Sintomas do Trato Urinário Inferior/fisiopatologia
Testosterona/análogos & derivados
Fenômenos Fisiológicos do Sistema Urinário/efeitos dos fármacos
Sistema Urinário/efeitos dos fármacos
Micção/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Terapia de Reposição Hormonal
Masculino
Contração Muscular/efeitos dos fármacos
Orquiectomia
Ratos
Ratos Sprague-Dawley
Reflexo/efeitos dos fármacos
Testosterona/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3XMK78S47O (Testosterone); H16A5VCT9C (testosterone undecanoate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160819
[St] Status:MEDLINE
[do] DOI:10.1152/ajprenal.00016.2016


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[PMID]:27261787
[Au] Autor:McDonough RC; Ryan ST
[Ad] Endereço:Division of Urology, Maine Medical Center, Tufts University School of Medicine, Portland, ME 04105, USA. Electronic address: mcdonr@mmc.org.
[Ti] Título:Diagnosis and Management of Lower Urinary Tract Dysfunction.
[So] Source:Surg Clin North Am;96(3):441-52, 2016 Jun.
[Is] ISSN:1558-3171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lower urinary tract dysfunction is an umbrella diagnosis that covers difficulty evacuating urine from the bladder. In its most simple form, it is either an inability to store urine or an inability to empty the bladder of urine appropriately. The normal and the abnormal bladder, the role of urodynamics in evaluation of lower urinary tract dysfunction, and the medical and behavioral management of some of these disorders are reviewed.
[Mh] Termos MeSH primário: Sintomas do Trato Urinário Inferior/fisiopatologia
Sintomas do Trato Urinário Inferior/terapia
Sistema Urinário/fisiopatologia
Doenças Urológicas/diagnóstico
Doenças Urológicas/terapia
[Mh] Termos MeSH secundário: Seres Humanos
Sintomas do Trato Urinário Inferior/etiologia
Fenômenos Fisiológicos do Sistema Urinário
Urodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160605
[St] Status:MEDLINE


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[PMID]:27186748
[Au] Autor:Wang DS
[Ti] Título:Re: Long-Term Changes in Renal Function Outcomes following Radical Cystectomy and Urinary Diversion.
[So] Source:J Urol;195(5):1511, 2016 May.
[Is] ISSN:1527-3792
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Cistectomia
Derivação Urinária
[Mh] Termos MeSH secundário: Seres Humanos
Bexiga Urinária
Neoplasias da Bexiga Urinária
Fenômenos Fisiológicos do Sistema Urinário
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160518
[St] Status:MEDLINE


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[PMID]:26866922
[Au] Autor:Fernandes VS; Hernández M
[Ad] Endereço:Department of Physiology, Faculty of Pharmacy, Complutense University of Madrid, 28040, Madrid, Spain.
[Ti] Título:The Role of Nitric Oxide and Hydrogen Sulfide in Urinary Tract Function.
[So] Source:Basic Clin Pharmacol Toxicol;119 Suppl 3:34-41, 2016 Oct.
[Is] ISSN:1742-7843
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This MiniReview focuses on the role played by nitric oxide (NO) and hydrogen sulfide (H S) in physiology of the upper and lower urinary tract. NO and H S, together with carbon monoxide, belong to the group of gaseous autocrine/paracrine messengers or gasotransmitters, which are employed for intra- and intercellular communication in almost all organ systems. Because they are lipid-soluble gases, gaseous transmitters are not constrained by cellular membranes, so that their storage in vesicles for later release is not possible. Gasotransmitter signals are terminated by falling concentrations upon reduction in production that are caused by reacting with cellular components (essentially reactive oxygen species and NO), binding to cellular components or diffusing away. NO and, more recently, H S have been identified as key mediators in neurotransmission of the urinary tract, involved in the regulation of ureteral smooth muscle activity and urinary flow ureteral resistance, as well as by playing a crucial role in the smooth muscle relaxation of bladder outlet region. Urinary bladder function is also dependent on integration of inhibitory mediators, such as NO, released from the urothelium. In the bladder base and distal ureter, the co-localization of neuronal NO synthase with substance P and calcitonin gene-related peptide in sensory nerves as well as the existence of a high nicotinamide adenine dinucleotide phosphate-diaphorase activity in dorsal root ganglion neurons also suggests the involvement of NO as a sensory neurotransmitter.
[Mh] Termos MeSH primário: Sulfeto de Hidrogênio/metabolismo
Modelos Biológicos
Óxido Nítrico/metabolismo
Fenômenos Fisiológicos do Sistema Urinário
Sistema Urinário/metabolismo
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Neurônios Motores/fisiologia
Relaxamento Muscular
Músculo Liso/irrigação sanguínea
Músculo Liso/inervação
Músculo Liso/fisiologia
Músculo Liso Vascular/inervação
Músculo Liso Vascular/fisiologia
Terminações Nervosas/fisiologia
Neurônios Aferentes/fisiologia
Sistema Urinário/irrigação sanguínea
Sistema Urinário/inervação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
31C4KY9ESH (Nitric Oxide); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160212
[St] Status:MEDLINE
[do] DOI:10.1111/bcpt.12565


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[PMID]:26407594
[Au] Autor:Klein JD; Wang Y; Mistry A; LaRocque LM; Molina PA; Rogers RT; Blount MA; Sands JM
[Ad] Endereço:Renal Division, Department of Medicine, and Department of Physiology, Emory University, Atlanta, Georgia janet.klein@emory.edu.
[Ti] Título:Transgenic Restoration of Urea Transporter A1 Confers Maximal Urinary Concentration in the Absence of Urea Transporter A3.
[So] Source:J Am Soc Nephrol;27(5):1448-55, 2016 May.
[Is] ISSN:1533-3450
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Urea has a critical role in urinary concentration. Mice lacking the inner medullary collecting duct (IMCD) urea transporter A1 (UT-A1) and urea transporter A3 (UT-A3) have very low levels of urea permeability and are unable to concentrate urine. To investigate the role of UT-A1 in the concentration of urine, we transgenically expressed UT-A1 in knockout mice lacking UT-A1 and UT-A3 using a construct with a UT-A1 gene that cannot be spliced to produce UT-A3. This construct was inserted behind the original UT-A promoter to yield a mouse expressing only UT-A1 (UT-A1(+/+)/UT-A3(-/-)). Western blot analysis demonstrated UT-A1 in the inner medulla of UT-A1(+/+)/UT-A3(-/-) and wild-type mice, but not in UT-A1/UT-A3 knockout mice, and an absence of UT-A3 in UT-A1(+/+)/UT-A3(-/-) and UT-A1/UT-A3 knockout mice. Immunohistochemistry in UT-A1(+/+)/UT-A3(-/-) mice also showed negative UT-A3 staining in kidney and other tissues and positive UT-A1 staining only in the IMCD. Urea permeability in isolated perfused IMCDs showed basal permeability in the UT-A1(+/+)/UT-A3(-/-) mice was similar to levels in wild-type mice, but vasopressin stimulation of urea permeability in wild-type mice was significantly greater (100% increase) than in UT-A1(+/+)/UT-A3(-/-) mice (8% increase). Notably, basal urine osmolalities in both wild-type and UT-A1(+/+)/UT-A3(-/-) mice increased upon overnight water restriction. We conclude that transgenic expression of UT-A1 restores basal urea permeability to the level in wild-type mice but does not restore vasopressin-stimulated levels of urea permeability. This information suggests that transgenic expression of UT-A1 alone in mice lacking UT-A1 and UT-A3 is sufficient to restore urine-concentrating ability.
[Mh] Termos MeSH primário: Proteínas de Membrana Transportadoras/genética
Ureia/urina
[Mh] Termos MeSH secundário: Animais
Proteínas de Membrana Transportadoras/fisiologia
Camundongos
Camundongos Knockout
Fenômenos Fisiológicos do Sistema Urinário
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Membrane Transport Proteins); 0 (urea transporter); 8W8T17847W (Urea)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170524
[Lr] Data última revisão:
170524
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150927
[St] Status:MEDLINE
[do] DOI:10.1681/ASN.2014121267


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[PMID]:26590449
[Au] Autor:Larsen B; Snow R; Aisbett B
[Ad] Endereço:School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, VIC 3125, Australia; Bushfire Co-Operative Research Centre, 340 Albert St, East Melbourne, VIC 3002, Australia. Electronic address: b.larsen@deakin.edu.au.
[Ti] Título:Effect of heat on firefighters' work performance and physiology.
[So] Source:J Therm Biol;53:1-8, 2015 Oct.
[Is] ISSN:0306-4565
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Wildland firefighters often perform their duties under both hot and mild ambient temperatures. However, the direct impact of different ambient temperatures on firefighters' work performance has not been quantified. This study compared firefighters' work performance and physiology during simulated wildland firefighting work in hot (HOT; 32°C, 43% RH) and temperate (CON; 19°C, 56% RH) conditions. Firefighters (n=38), matched and allocated to either the CON (n=18) or HOT (n=20) condition, performed simulated self-paced wildland fire suppression tasks (e.g., hose rolling/dragging, raking) in firefighting clothing for six hours, separated by dedicated rest breaks. Task repetitions were counted (and converted to distance or area). Core temperature (Tc), skin temperature (Tsk), and heart rate were recorded continuously throughout the protocol. Urine output was measured before and during the protocol, and urine specific gravity (USG) analysed, to estimate hydration. Ad libitum fluid intake was also recorded. There were no differences in overall work output between conditions for any physical task. Heart rate was higher in the HOT (55±2% HRmax) compared to the CON condition (51±2% HRmax) for the rest periods between bouts, and for the static hose hold task (69±3% HRmax versus 65±3% HRmax). Tc and Tsk were 0.3±0.1°C and 3.1±0.2°C higher in the HOT compared to the CON trial. Both pre- and within- shift fluid intake were increased two-fold in the heat, and participants in the heat recorded lower USG results than their CON counterparts. There was no difference between the CON and HOT conditions in terms of their work performance, and firefighters in both experimental groups increased their work output over the course of the simulated shift. Though significantly hotter, participants in the heat also managed to avoid excessive cardiovascular and thermal strain, likely aided by the frequent rest breaks in the protocol, and through doubling their fluid intake. Therefore, it can be concluded that wildland firefighters are able to safely and efficiently perform their duties under hot conditions, at least over six hours.
[Mh] Termos MeSH primário: Temperatura Corporal
Bombeiros
Frequência Cardíaca
Temperatura Alta
Fenômenos Fisiológicos do Sistema Urinário
Desempenho Profissional
[Mh] Termos MeSH secundário: Adulto
Ingestão de Líquidos
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151123
[St] Status:MEDLINE



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