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[PMID]:25458658
[Au] Autor:Park M; Vittinghoff E; Shlipak MG; Mishra R; Whooley M; Bansal N
[Ad] Endereço:University of California, San Francisco, Division of Nephrology, San Francisco, CA. Electronic address: meyeon.park@ucsf.edu.
[Ti] Título:Associations of N-terminal pro-B-type natriuretic peptide with kidney function decline in persons without clinical heart failure in the Heart and Soul Study.
[So] Source:Am Heart J;168(6):931-9.e2, 2014 Dec.
[Is] ISSN:1097-6744
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Subclinical volume overload in the absence of diagnosed heart failure (HF) may be an underrecognized contributor to kidney function decline in coronary artery disease (CAD) patients. We evaluated associations of circulating N-terminal pro-B-type natriuretic peptide (NT-proBNP), a marker of ventricular stretch, with change in estimated glomerular filtration rate (eGFR). METHODS: We evaluated 535 patients with stable CAD and no history of HF, who were enrolled in the Heart and Soul Study and followed for 5 years. N-terminal pro-B-type natriuretic peptide was measured at baseline. We evaluated the associations of NT-proBNP with change in kidney function over 5 years: (a) annual percent change in eGFR, (b) rapid kidney function loss (> 3% per year for 5 years), and (c) incident eGFR < 60 mL/min per 1.73 m2. In multivariable models, we adjusted for demographics, comorbid conditions, echocardiographic parameters, medications, and baseline kidney function. RESULTS: Among 535 participants, median NT-proBNP was 130.6 (interquartile range 61.8-280.9) pg/mL, and median B-type natriuretic peptide (BNP) was 32.5 (14.4-75.9) pg/mL. Individuals with NT-proBNP levels in the highest quartile (> 280.9 pg/mL) had a greater odds of rapid kidney function loss after full adjustment (odds ratio 2.95; 95% CI 1-8.65; P = .0492). Associations with incident eGFR < 60 mL/min per 1.73 m2 were also significant (adjusted odds ratio 4.23; 95% CI 1.05-16.98; P = .0422). Results were similar when analyzed using BNP as the predictor. CONCLUSIONS: N-terminal pro-B-type natriuretic peptide and BNP are strongly and independently associated with accelerated kidney function loss, even in the absence of clinical HF. These findings suggest that subclinical cardiovascular dysfunction may contribute to elevated kidney disease risk in persons with CAD.
[Mh] Termos MeSH primário: Doença da Artéria Coronariana
Insuficiência Cardíaca
Peptídeo Natriurético Encefálico/sangue
Fragmentos de Peptídeos/sangue
Insuficiência Renal
[Mh] Termos MeSH secundário: Idoso
Doenças Assintomáticas
Biomarcadores/sangue
Doença da Artéria Coronariana/sangue
Doença da Artéria Coronariana/complicações
Doença da Artéria Coronariana/epidemiologia
Doença da Artéria Coronariana/fisiopatologia
Progressão da Doença
Feminino
Seguimentos
Taxa de Filtração Glomerular
Insuficiência Cardíaca/diagnóstico
Insuficiência Cardíaca/etiologia
Insuficiência Cardíaca/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Prognóstico
Estudos Prospectivos
Fluxo Sanguíneo Renal Efetivo
Insuficiência Renal/sangue
Insuficiência Renal/diagnóstico
Insuficiência Renal/epidemiologia
Insuficiência Renal/etiologia
Insuficiência Renal/fisiopatologia
Fatores de Risco
Estados Unidos/epidemiologia
Função Ventricular/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Peptide Fragments); 0 (pro-brain natriuretic peptide (1-76)); 114471-18-0 (Natriuretic Peptide, Brain)
[Em] Mês de entrada:1502
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:141203
[St] Status:MEDLINE


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[PMID]:23585555
[Au] Autor:Tsuda A; Inaba M; Ichii M; Ochi A; Ohno Y; Nakatani S; Yamada S; Mori K; Tahara H; Ishimura E
[Ad] Endereço:Departments of Nephrology, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. naranotsudadesu@infoseek.jp
[Ti] Título:Relationship between serum TSH levels and intrarenal hemodynamic parameters in euthyroid subjects.
[So] Source:Eur J Endocrinol;169(1):45-50, 2013 Jul.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Low thyroid function may be associated with a reduced glomerular filtration rate (GFR) calculated on the basis of creatinine metabolism. Thyroid hormone directly affects serum creatinine in muscle and low thyroid function might exert a similar direct effect in the kidney. The goal of the study was to evaluate this possibility by assessment of the inulin-based GFR and to examine the mechanism underlying the reduction of GFR. PATIENTS AND METHODS: Renal and glomerular hemodynamics were assessed by simultaneous measurements of plasma clearance of para-aminohippurate (CPAH) and inulin (Cin) in 26 patients with serum creatinine <1.00 mg/dl and without thyroid disease. All subjects were normotensive with or without antihypertensive treatment and were kept in a sodium-replete state. Renal and glomerular hemodynamics were calculated using Gomez's formulae. RESULTS: Serum TSH, including within the normal range (0.69-4.30 µIU/ml), was positively correlated with vascular resistance at the afferent arteriole (Ra) (r=0.609, P=0.0010), but not at the efferent arteriole (Re). Serum TSH was significantly and negatively correlated with renal plasma flow (RPF), renal blood flow (RBF), and GFR (r=-0.456, P=0.0192; r=-0.438, P=0.0252; r=-0.505, P=0.0086 respectively). In multiple regression analysis, serum TSH was significantly positively associated with Ra after adjustment for age and mean blood pressure. CONCLUSIONS: These findings suggest that low thyroid function, even within the normal range, is associated with reduced RPF, RBF, and GFR, which might be caused by a preferential increase in Ra.
[Mh] Termos MeSH primário: Creatinina/metabolismo
Taxa de Filtração Glomerular
Hipotireoidismo/metabolismo
Circulação Renal
Tireotropina/sangue
Ácido p-Aminoipúrico/sangue
[Mh] Termos MeSH secundário: Adulto
Idoso
Aterosclerose/etiologia
Biomarcadores/sangue
Pressão Sanguínea
Creatinina/sangue
Feminino
Seres Humanos
Hipotireoidismo/sangue
Hipotireoidismo/complicações
Inulina/sangue
Japão
Masculino
Meia-Idade
Fluxo Sanguíneo Renal Efetivo
Fluxo Plasmático Renal
Fatores de Risco
Resistência Vascular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 9002-71-5 (Thyrotropin); 9005-80-5 (Inulin); AYI8EX34EU (Creatinine); Y79XT83BJ9 (p-Aminohippuric Acid)
[Em] Mês de entrada:1307
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130416
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-13-0026


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[PMID]:22019735
[Au] Autor:Sacquépée M; Tivollier JM; Doussy Y; Quirin N; Valéry JC; Cantin JF
[Ad] Endereço:Hémodialyse, association pour le traitement de l'insuffisance rénale en Nouvelle-Calédonie (ATIR NC), 193, rue Benebig, Vallées-des-Colons, BP 3996, 98846 Nouméa cedex, Nouvelle-Calédonie. msacquepee@atir.asso.nc
[Ti] Título:[Comparison of different techniques of hemodialysis vascular access flow evaluation: blood temperature monitoring thermodilution and doppler debimetry].
[Ti] Título:Comparaison des mesures des débits d'abords vasculaires pour hémodialyse obtenues par méthode de thermodilution utilisant le module Blood Temperature Monitoring et par débimétrie doppler..
[So] Source:Nephrol Ther;8(2):96-100, 2012 Apr.
[Is] ISSN:1872-9177
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:BACKGROUND: Access blood flow measurements are considered useful indicators for thrombosis prevention. It was the purpose of this study to compare measurements of access blood flow by two different techniques: duplex doppler and BTM thermodilution. METHODS: Patients included must be on chronic hemodialysis on arterioveinous vascular access. They must be in a unit fit with hemodialysis generator equipped with BTM tool. The measurements of access blood flow were made during the first hour of the hemodialysis session. A measurement with each technique was performed for each patient. RESULTS: Fifteen patients were included: seven men and eight women, average age 60.8 ± 9.2 years, average weight 76 ± 16 kg, duration on hemodialysis therapy 6.6 ± 6.1 years. Access blood flow was native fistula (14 patients) and a prothetic access (one patient). Average access blood flow was 1088 ± 586 mL/mn (doppler) and 1094 ± 570 mL/mn (BTM). Comparison of access flows obtained by the BTM and doppler techniques showed a strong linear relationship. The average time to perform a measure was six minutes for the doppler technique and five minutes for the BTM technique. No adverse effect was observed in our study. CONCLUSION: Our study shows a strong correlation between the two techniques (doppler and BTM) for the measurement of hemodialysis access blood flow. The BTM access blood flow measurement technique is fast, economic and made during the hemodialysis session by the nurse.
[Mh] Termos MeSH primário: Derivação Arteriovenosa Cirúrgica/métodos
Fluxo Sanguíneo Renal Efetivo/fisiologia
Diálise Renal/métodos
Termodiluição/métodos
Ultrassonografia Doppler Dupla/métodos
Dispositivos de Acesso Vascular/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Monitorização Fisiológica
Temperatura Ambiente
Trombose/prevenção & controle
[Pt] Tipo de publicação:COMPARATIVE STUDY; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mês de entrada:1312
[Cu] Atualização por classe:120416
[Lr] Data última revisão:
120416
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:111025
[St] Status:MEDLINE
[do] DOI:10.1016/j.nephro.2011.09.001


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[PMID]:21864246
[Au] Autor:Bhadwal M; Satpati D; Singhal S; Sarma HD; Venkatesh M; Banerjee S
[Ad] Endereço:Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India.
[Ti] Título:Preparation of 99mTc(CO)3-Carboxymethylthioethyl iminodiacetic acid and evaluation as a potential renal imaging agent.
[So] Source:Curr Radiopharm;5(1):65-70, 2012 Jan.
[Is] ISSN:1874-4729
[Cp] País de publicação:United Arab Emirates
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: The ligand, carboxymethylthioethyl iminodiacetic acid (CMT-IDA) has a suitable array of donor atoms for coordination with [99mTc(CO)3]+ core, wherein the resultant complex is expected to possess free carboxylic residues contributing towards hydrophilicity of the complex. The aim of the studies was to study the renal clearance of 99mTc(CO)3- labeled CMT-IDA and determine the potential of the complex towards its use as a renal tubular imaging agent. METHODS: CMT-IDA was radiolabeled with the [99mTc(CO)3(H2O)3]+ precursor and was characterized by reverse phase HPLC gradient elution system. Stability, hydrophilicity and plasma protein binding studies were carried out for the complex. Biodistribution studies were carried out in normal male Swiss mice at 10 min.p.i. and 2 h.p.i. The clearance was estimated from the activity observed in the urinary bladder by tying the urethra prior to injection of the complexes under study. Imaging studies were performed with male Swiss mice administered with [99mTc(CO)3(CMT-IDA)]-2 at 30 min. p.i. and blocking studies were carried out by intraperitoneal injection of probenecid 10 min. prior to the injection of the radiotracer. RESULTS: [99mTc(CO)3(CMT-IDA)]-2 could be obtained in > 98% radiochemical purity. The complex showed renal clearance of 71.0� 5.9% ID at 10 min.p.i. which increased to 84.1� 10.6% ID at 2 h.p.i., with no major activity in blood, liver, heart, lungs, stomach and spleen. However, the intestinal uptake was high (10.3� 2.0% ID) at 2 h.p.i. Scintigraphic image of the animal injected with probenecid showed an increase in the activity in kidneys indicating excretion of the [99mTc(CO)3(CMT-IDA)]-2 complex via tubular pathway. CONCLUSION: The complex, [99mTc(CO)3(CMT-IDA)]-2 has shown excellent renal clearance and thereby can be explored further for potential use as an agent towards assessing effective renal plasma flow.
[Mh] Termos MeSH primário: Iminoácidos/síntese química
Túbulos Renais/metabolismo
Compostos de Organotecnécio/síntese química
Compostos Radiofarmacêuticos/síntese química
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão
Iminoácidos/farmacocinética
Túbulos Renais/diagnóstico por imagem
Túbulos Renais/fisiologia
Masculino
Camundongos
Compostos de Organotecnécio/farmacocinética
Cintilografia
Compostos Radiofarmacêuticos/farmacocinética
Fluxo Sanguíneo Renal Efetivo/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (99mTc(CO)3-carboxymethylthioethyl iminodiacetic acid); 0 (Imino Acids); 0 (Organotechnetium Compounds); 0 (Radiopharmaceuticals); XQM2L81M8Z (iminodiacetic acid)
[Em] Mês de entrada:1206
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110826
[St] Status:MEDLINE


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[PMID]:21769680
[Au] Autor:Porpiglia F; Fiori C; Bertolo R; Angusti T; Piccoli GB; Podio V; Russo R
[Ad] Endereço:S.C.D.U. Urologia, Azienda Ospedaliera Universitaria "San Luigi Gonzaga", Orbassano, TO, Italy. porpiglia@libero.it
[Ti] Título:The effects of warm ischaemia time on renal function after laparoscopic partial nephrectomy in patients with normal contralateral kidney.
[So] Source:World J Urol;30(2):257-63, 2012 Apr.
[Is] ISSN:1433-8726
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To assess the effects of warm ischaemia time (WIT) on renal function after laparoscopic partial nephrectomy (LPN) for renal masses in patients with a normal contralateral kidney. METHODS: From October 2006 to December 2008, 53 patients treated with LPN were enrolled in this prospective study. Effective renal plasma flow (ERPF) was estimated with 99mTc-mercaptoacetyltriglycine renal scintigraphy before the intervention and after 3 and 12 months. Multiple linear regression analysis was used to assess the effects of demographic and operative variables on postoperative renal function. Logistic regression analysis was used to evaluate the associations between the same variables and a ≥20% reduction in postoperative ERPF compared with baseline (defined as significant loss of renal function-LRF). ROC curve analysis was used to identify potential ischaemia time cut-off points. RESULTS: Fifty-one patients were eligible. The mean lesion size was 30 mm, and the mean WIT was 21.9 min. Longer WIT was associated with lower postoperative ERPF values (P < 0.001). A logistic regression model confirmed that longer WITs were significantly associated with ERPF decreases ≥20% (OR 1.454 and 1.741, for each 1-min increase, respectively). ROC analysis identified 25 min as a 'safe' cut-off for WIT (AUC 0.874, P < 0.001). Postoperative ERPF differences between the two groups (WIT ≤25 and >25 min) were significant. CONCLUSIONS: Longer WIT was associated with LRF, as estimated with renal scintigraphy. LRF occurred within 3 months and remains stable until the 12th month after LPN. Every effort should be made to minimise warm ischaemic intervals during LPN, and the limit of 25 min should be not exceeded.
[Mh] Termos MeSH primário: Neoplasias Renais/cirurgia
Rim/fisiopatologia
Laparoscopia/efeitos adversos
Nefrectomia/efeitos adversos
Fluxo Sanguíneo Renal Efetivo
Isquemia Quente
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Rim/diagnóstico por imagem
Modelos Logísticos
Masculino
Meia-Idade
Nefrectomia/métodos
Imagem de Perfusão
Compostos Radiofarmacêuticos
Tecnécio Tc 99m Mertiatida
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 36ITO9SKQJ (Technetium Tc 99m Mertiatide)
[Em] Mês de entrada:1207
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110720
[St] Status:MEDLINE
[do] DOI:10.1007/s00345-011-0729-5


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[PMID]:21865724
[Au] Autor:Gashti CN; Rodby RA; Huang Z; Gao D; Zhang W
[Ad] Endereço:Section of Nephrology, Rush University Medical Center, Chicago, Ill., USA. Casey_Gashti @ rush.edu
[Ti] Título:Effects of high blood flow and high pre-dilution replacement fluid rates on small solute clearances in hemofiltration.
[So] Source:Blood Purif;32(4):266-70, 2011.
[Is] ISSN:1421-9735
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: In pre-dilution hemofiltration (HF), solute clearance is less than the HF rate. While the amount of this loss is predictable, it has not been validated in high-volume HF associated with high blood flow rates. METHODS: Using isovolemic pre-dilution HF, we studied small solute clearances using combinations of blood flow (Q(B); 150, 250, 350, 450 ml/min) and replacement fluid (RF) flow (Q(RF); 2, 4, 6 l/h) to determine clearance losses we entitled 'measured efficiency' (E(M)). E(M) was compared to predicted efficiency (E(P)) = (Q(B)/Q(B) + Q(RF)). RESULTS: Pre-dilution produced E(M) values of 61-93%. Increases in Q(B) for any Q(RF) and decreases in Q(RF) for any Q(B) increased E(M) over a wide range of Q(B) and Q(RF). E(P) was equivalent to E(M). CONCLUSION: In high-volume pre-dilution HF, E(P) can be used to determine E(M) across a broad range of Q(B) and Q(RF) values. Higher Q(RF) requires higher Q(B) to minimize the attenuating effects of pre-dilution on clearance.
[Mh] Termos MeSH primário: Creatinina/metabolismo
Hemofiltração
Fluxo Sanguíneo Renal Efetivo
Ureia/metabolismo
[Mh] Termos MeSH secundário: Seres Humanos
Cinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
8W8T17847W (Urea); AYI8EX34EU (Creatinine)
[Em] Mês de entrada:1204
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110826
[St] Status:MEDLINE
[do] DOI:10.1159/000328740


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[PMID]:21822604
[Au] Autor:Palazzuoli A; Ronco C
[Ad] Endereço:Department of Internal Medicine and Metabolic Diseases, Cardiology Section, University of Siena, Siena, Italy. palazzuoli2@unisi.it
[Ti] Título:Cardio-renal syndrome: an entity cardiologists and nephrologists should be dealing with collegially.
[So] Source:Heart Fail Rev;16(6):503-8, 2011 Nov.
[Is] ISSN:1573-7322
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Heart failure may lead to acute kidney injury and vice versa. Chronic kidney disease may affect the clinical outcome in terms of cardiovascular morbidity and mortality while chronic heart failure may cause CKD. All these disorders contribute to the composite definition of cardio-renal syndromes. Renal impairment in HF patients has been increasingly recognized as an independent risk factor for morbidity and mortality; however, the most important clinical trials in HF tend to exclude patients with significant renal dysfunction. The mechanisms whereby renal insufficiency worsens the outcome in HF are not known, and several pathways could contribute to the "vicious heart/kidney circle." Traditionally, renal impairment has been attributed to the renal hypoperfusion due to reduced cardiac output and decreased systemic pressure. The hypovolemia leads to sympathetic activity, increased renin-angiotensin-aldosterone pathways and arginine-vasopressin release. All these mechanisms cause fluid and sodium retention, peripheral vasoconstriction and an increased congestion as well as cardiac workload. Therapy addressed to improve renal dysfunction, reduce neurohormonal activation and ameliorate renal blood flow could lead to a reduction in mortality and hospitalization in patients with cardio-renal syndrome.
[Mh] Termos MeSH primário: Biomarcadores
Síndrome Cardiorrenal
Fármacos Cardiovasculares
Diuréticos/efeitos adversos
Coração/fisiopatologia
Rim
Desequilíbrio Hidroeletrolítico/fisiopatologia
[Mh] Termos MeSH secundário: Débito Cardíaco/efeitos dos fármacos
Síndrome Cardiorrenal/tratamento farmacológico
Síndrome Cardiorrenal/metabolismo
Síndrome Cardiorrenal/mortalidade
Síndrome Cardiorrenal/fisiopatologia
Fármacos Cardiovasculares/farmacocinética
Fármacos Cardiovasculares/uso terapêutico
Progressão da Doença
Seres Humanos
Comunicação Interdisciplinar
Rim/irrigação sanguínea
Rim/fisiopatologia
Testes de Função Renal
Conduta do Tratamento Medicamentoso/organização & administração
Seleção de Pacientes
Fluxo Sanguíneo Renal Efetivo/efeitos dos fármacos
Sistema Renina-Angiotensina/efeitos dos fármacos
Fatores de Risco
Choque/tratamento farmacológico
Choque/metabolismo
Choque/fisiopatologia
Desequilíbrio Hidroeletrolítico/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cardiovascular Agents); 0 (Diuretics)
[Em] Mês de entrada:1201
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110809
[St] Status:MEDLINE
[do] DOI:10.1007/s10741-011-9267-x


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[PMID]:21259069
[Au] Autor:Ronco C
[Ad] Endereço:Department of Nephrology, Ospedale San Bortolo, 361000, Vicenza, Italy. cronco@goldnet.it
[Ti] Título:Cardio-renal syndromes: from foggy bottoms to sunny hills.
[So] Source:Heart Fail Rev;16(6):509-17, 2011 Nov.
[Is] ISSN:1573-7322
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:"Cardio-renal syndromes" (CRS) are disorders of the heart and kidneys whereby acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other. The current definition has been expanded into five subtypes whose etymology reflects the primary and secondary pathology, the time-frame and simultaneous cardiac and renal co-dysfunction secondary to systemic disease: CRS type I: acute worsening of heart function (AHF-ACS) leading to kidney injury and/or dysfunction. CRS type II: chronic abnormalities in heart function (CHF-CHD) leading to kidney injury or dysfunction. CRS type III: acute worsening of kidney function (AKI) leading to heart injury and/or dysfunction. CRS type IV: chronic kidney disease (CKD) leading to heart injury, disease and/or dysfunction. CRS type V: systemic conditions leading to simultaneous injury and/or dysfunction of heart and kidney. These different subtypes may have a different pathophysiological mechanism and they may represent separate entities in terms of prevention and therapy.
[Mh] Termos MeSH primário: Síndrome Cardiorrenal
Fármacos Cardiovasculares
Meios de Contraste/efeitos adversos
Diuréticos/efeitos adversos
Coração/fisiopatologia
Rim/fisiopatologia
[Mh] Termos MeSH secundário: Biomarcadores
Síndrome Cardiorrenal/classificação
Síndrome Cardiorrenal/tratamento farmacológico
Síndrome Cardiorrenal/genética
Síndrome Cardiorrenal/metabolismo
Síndrome Cardiorrenal/fisiopatologia
Fármacos Cardiovasculares/administração & dosagem
Fármacos Cardiovasculares/efeitos adversos
Fármacos Cardiovasculares/farmacocinética
Meios de Contraste/farmacocinética
Diuréticos/administração & dosagem
Diuréticos/farmacocinética
Interação Gene-Ambiente
Seres Humanos
Fluxo Sanguíneo Renal Efetivo/efeitos dos fármacos
Sistema Renina-Angiotensina/efeitos dos fármacos
Fatores de Risco
Choque/tratamento farmacológico
Choque/metabolismo
Choque/fisiopatologia
Terminologia como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cardiovascular Agents); 0 (Contrast Media); 0 (Diuretics)
[Em] Mês de entrada:1201
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110125
[St] Status:MEDLINE
[do] DOI:10.1007/s10741-011-9226-6


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[PMID]:20930090
[Au] Autor:Meijer E; Bakker SJ; van der Jagt EJ; Navis G; de Jong PE; Struck J; Gansevoort RT
[Ad] Endereço:Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
[Ti] Título:Copeptin, a surrogate marker of vasopressin, is associated with disease severity in autosomal dominant polycystic kidney disease.
[So] Source:Clin J Am Soc Nephrol;6(2):361-8, 2011 Feb.
[Is] ISSN:1555-905X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: Experimental studies suggest a detrimental role for vasopressin in the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD). However, it is unknown whether endogenous vasopressin concentration is associated with disease severity in patients with ADPKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Plasma copeptin concentration (a marker of endogenous vasopressin levels) was measured in 102 ADPKD patients (diagnosis based on Ravine criteria) by an immunoassay. Plasma and urinary osmolarity were also measured. To assess disease severity, GFR and effective renal blood flow were measured by continuous infusion of 125I-iothalamate and 131I-hippuran, total renal volume by magnetic resonance imaging, and 24-hour urinary albumin excretion by nephelometry. RESULTS: In these ADPKD patients, copeptin was associated with the various markers of disease severity in ADPKD (positively with total renal volume [R=0.47] and albuminuria [R=0.39] and negatively with GFR [R=-0.58] and effective renal blood flow [R=-0.52], all P<0.001). These associations were independent of age, gender, and use of diuretics. Copeptin was furthermore associated with plasma osmolarity (P<0.001) but not with 24-hour urinary volume, 24-hour urinary osmolarity or fractional urea excretion (P=0.7, 0.9, and 0.3, respectively). CONCLUSIONS: On cross-sectional analysis, copeptin is associated with disease severity in ADPKD patients, supporting the results of experimental studies that suggest that vasopressin antagonists have a renoprotective effect in ADPKD and offering a good prospect for clinical studies with these agents.
[Mh] Termos MeSH primário: Glicopeptídeos/sangue
Rim Policístico Autossômico Dominante/diagnóstico
Vasopressinas/sangue
[Mh] Termos MeSH secundário: Adulto
Albuminúria/sangue
Albuminúria/diagnóstico
Albuminúria/fisiopatologia
Albuminúria/urina
Biomarcadores/sangue
Estudos Transversais
Feminino
Taxa de Filtração Glomerular
Seres Humanos
Imunoensaio
Radioisótopos do Iodo
Ácido Iodoipúrico
Ácido Iotalâmico
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Nefelometria e Turbidimetria
Países Baixos
Concentração Osmolar
Rim Policístico Autossômico Dominante/sangue
Rim Policístico Autossômico Dominante/fisiopatologia
Rim Policístico Autossômico Dominante/urina
Valor Preditivo dos Testes
Análise de Regressão
Fluxo Sanguíneo Renal Efetivo
Índice de Gravidade de Doença
Urodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Glycopeptides); 0 (Iodine Radioisotopes); 0 (copeptins); 11000-17-2 (Vasopressins); 147-58-0 (Iodohippuric Acid); 16CHD79MIX (Iothalamic Acid)
[Em] Mês de entrada:1106
[Cu] Atualização por classe:161215
[Lr] Data última revisão:
161215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101009
[St] Status:MEDLINE
[do] DOI:10.2215/CJN.04560510


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[PMID]:21088293
[Au] Autor:O'Hare AM; Covinsky KE
[Ti] Título:Prediction modeling to assess the prognostic significance of a biomarker panel.
[So] Source:J Am Soc Nephrol;21(12):2017-9, 2010 Dec.
[Is] ISSN:1533-3450
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Biomarcadores/análise
Taxa de Filtração Glomerular
Nefropatias/diagnóstico
Modelos Biológicos
Fluxo Sanguíneo Renal Efetivo/fisiologia
[Mh] Termos MeSH secundário: Seres Humanos
Valor Preditivo dos Testes
Prognóstico
Sensibilidade e Especificidade
[Pt] Tipo de publicação:COMMENT; EDITORIAL
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1101
[Cu] Atualização por classe:161025
[Lr] Data última revisão:
161025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101120
[St] Status:MEDLINE
[do] DOI:10.1681/ASN.2010101078



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