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Pesquisa : G09.188 [Categoria DeCS]
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[PMID]:29174782
[Au] Autor:St-Onge S; Perrault LP; Demers P; Boyle EM; Gillinov AM; Cox J; Melby S
[Ad] Endereço:Department of Cardiac Surgery, Montreal Heart Institute, Université de Montréal, Quebec, Canada.
[Ti] Título:Pericardial Blood as a Trigger for Postoperative Atrial Fibrillation After Cardiac Surgery.
[So] Source:Ann Thorac Surg;105(1):321-328, 2018 Jan.
[Is] ISSN:1552-6259
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Prevention strategies have long been sought to reduce the incidence and burden of postoperative atrial fibrillation (POAF) after heart surgery. However, none has emerged as a dominant and widely applicable prophylactic measure. The purpose of this review is to consider the biological mechanisms by which shed mediastinal blood leads to oxidation and inflammation within the postoperative pericardial environment and how this might trigger POAF in susceptible persons, as well as how it could represent a new target for prevention of POAF. METHODS: We conducted a structured research of literature using PubMed and MEDLINE databases to May 2016. Biomolecular and clinical articles focused on assessing the contribution of pericardial blood, or the resulting inflammation within the pericardial space and its potential role in triggering POAF, were included in this review. RESULTS: Evidence suggests that shed mediastinal blood through breakdown products, activation of coagulation cascade, and oxidative burst contributes to a highly pro-oxidant and proinflammatory milieu found within the pericardial space that can trigger postoperative atrial fibrillation in susceptible persons. The extent of this reaction could be blunted by reducing the exposition of pericardium to blood either through posterior pericardiotomy or improved chest drainage. CONCLUSIONS: Shed mediastinal blood undergoing transformation within the pericardium appears to be an important contributing factor to POAF. Strategies to prevent shed mediastinal blood from pooling around the heart might be considered in developing future paradigms for prevention of POAF.
[Mh] Termos MeSH primário: Fibrilação Atrial/etiologia
Sangue
Procedimentos Cirúrgicos Cardíacos
Pericárdio
Complicações Pós-Operatórias/etiologia
[Mh] Termos MeSH secundário: Fibrilação Atrial/prevenção & controle
Fenômenos Fisiológicos Sanguíneos
Seres Humanos
Mediastino
Complicações Pós-Operatórias/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:28552917
[Au] Autor:Szymonowicz M; Kucharska M; Wisniewska-Wrona M; Dobrzynski M; Kolodziejczyk K; Rybak Z
[Ad] Endereço:Department of Experimental Surgery and Biomaterials Research, Medical University, Wroclaw, Poland.
[Ti] Título:The evaluation of resorbable haemostatic wound dressings in contact with blood in vitro.
[So] Source:Acta Bioeng Biomech;19(1):151-165, 2017.
[Is] ISSN:1509-409X
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:PURPOSE: For many years research has been conducted on the development of resorbable, polymer, haemostatic materials designed to provide first aid and preliminary protection of injuries. The biological properties in vitro of a dressing in powder form called Hemoguard are expected to provide the ability to instantaneously stem bleeding with safe conditions of use. The aim of the study was to evaluate the haemostatic properties of a model of dressing based on micro- and nanofibrids of the chitosan, sodium/calcium alginate and/or carboxymethylcellulose complex. Dressings were prepared by spray-drying and freeze-drying. METHODS: Human whole blood was subjected to timed contact with the haemostatic dressing model. Haemolytic action was determined by assaying the degree of haemolysis and evaluating blood cell morphology. Haemostatic action was determined on the basis of selected parameters of plasmatic clotting systems. RESULTS: Dressings prepared by freeze-drying activated the coagulation system. The haemolytic index, plasma haemoglobin concentration values and blood cell morphological shapes were normal. Dressings prepared by spray-drying significantly activated coagulation. Activation of the coagulation process was evidenced by shorter clotting time of the plasma coagulation system and a longer process of clot formation. The dressing was associated with an increased haemolytic index and higher plasma haemoglobin concentration. The morphological shape of blood cells changed. CONCLUSIONS: The model of multi-resorbable wound dressings has haemostatic properties. The materials activate the clotting process more quickly than a single-dressing model. Increased activity was found for dressings prepared by spray-drying.
[Mh] Termos MeSH primário: Implantes Absorvíveis
Bandagens
Coagulação Sanguínea/fisiologia
Fenômenos Fisiológicos Sanguíneos/efeitos dos fármacos
Técnicas Hemostáticas/instrumentação
Hemostáticos/administração & dosagem
[Mh] Termos MeSH secundário: Coagulação Sanguínea/efeitos dos fármacos
Desenho de Equipamento
Análise de Falha de Equipamento
Hemostáticos/química
Seres Humanos
Técnicas In Vitro
Teste de Materiais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hemostatics)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE


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[PMID]:28140791
[Au] Autor:Broustas CG; Xu Y; Harken AD; Chowdhury M; Garty G; Amundson SA
[Ad] Endereço:a Center for Radiological Research, Columbia University Medical Center, New York, New York 10032; and.
[Ti] Título:Impact of Neutron Exposure on Global Gene Expression in a Human Peripheral Blood Model.
[So] Source:Radiat Res;187(4):433-440, 2017 Apr.
[Is] ISSN:1938-5404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The detonation of an improvised nuclear device would produce prompt radiation consisting of both photons (gamma rays) and neutrons. While much effort in recent years has gone into the development of radiation biodosimetry methods suitable for mass triage, the possible effect of neutrons on the endpoints studied has remained largely uninvestigated. We have used a novel neutron irradiator with an energy spectrum based on that 1-1.5 km from the epicenter of the Hiroshima blast to begin examining the effect of neutrons on global gene expression, and the impact this may have on the development of gene expression signatures for radiation biodosimetry. We have exposed peripheral blood from healthy human donors to 0.1, 0.3, 0.5 or 1 Gy of neutrons ex vivo using our neutron irradiator, and compared the transcriptomic response 24 h later to that resulting from sham exposure or exposure to 0.1, 0.3, 0.5, 1, 2 or 4 Gy of photons (X rays). We identified 125 genes that responded significantly to both radiation qualities as a function of dose, with the magnitude of response to neutrons generally being greater than that seen after X-ray exposure. Gene ontology analysis suggested broad involvement of the p53 signaling pathway and general DNA damage response functions across all doses of both radiation qualities. Regulation of immune response and chromatin-related functions were implicated only following the highest doses of neutrons, suggesting a physiological impact of greater DNA damage. We also identified several genes that seem to respond primarily as a function of dose, with less effect of radiation quality. We confirmed this pattern of response by quantitative real-time RT-PCR for BAX, TNFRSF10B, ITLN2 and AEN and suggest that gene expression may provide a means to differentiate between total dose and a neutron component.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos Sanguíneos/genética
Fenômenos Fisiológicos Sanguíneos/efeitos da radiação
Sangue/efeitos da radiação
Transcriptoma/efeitos da radiação
[Mh] Termos MeSH secundário: Feminino
Regulação da Expressão Gênica/efeitos da radiação
Ontologia Genética
Seres Humanos
Masculino
Nêutrons
Análise de Sequência com Séries de Oligonucleotídeos
Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.1667/RR0005.1


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[PMID]:26956460
[Au] Autor:Króliczewska B; Mista D; Króliczewski J; Zawadzki W; Kubaszewski R; Wincewicz E; Zuk M; Szopa J
[Ad] Endereço:Department of Animal Physiology and Biostructure, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Norwida 31, PL-50-375, Wroclaw, Poland.
[Ti] Título:A new genotype of flax (Linum usitatissimum L.) with decreased susceptibility to fat oxidation: consequences to hematological and biochemical profiles of blood indices.
[So] Source:J Sci Food Agric;97(1):165-171, 2017 Jan.
[Is] ISSN:1097-0010
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Flaxseed is an alternative to marine products that provide the traditional dietary sources of ω-fatty acids. A new genotype of flax, W92, is rich in natural antioxidants as well as having a reduced content of α-linolenic acid and therefore shows decreased susceptibility to fat oxidation. The objective of this study was to evaluate the effect of a diet supplemented with W92 flaxseed on hematological and biochemical blood indices. RESULTS: A positive impact of diet with the addition of flaxseed was observed on erythrocyte indices, including red blood cell (RBC), hematocrit (HCT), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) values. There were no significant differences for white blood cell (WBC), total protein and glucose values. Aspartate aminotransferase and alanine aminotransferase estimations in serum were also carried out and no obvious toxicity to the liver was shown. Moreover, a lipid profile was performed in serum samples and a decrease in total cholesterol and low-density lipoprotein cholesterol (LDL-C), accompanied by an increase in high-density lipoprotein cholesterol (HDL-C), was observed in rabbits fed flaxseed diets. CONCLUSION: Based on the results obtained, it appeared that the inclusion of a new genetically modified type of flaxseed in the diet altered cholesterol metabolism and could reduce the possibility of cardiovascular diseases. Diet enrichment with W92 flaxseed may be a solution to the health issues that are a result of improper diet in humans and animals. © 2016 Society of Chemical Industry.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos Sanguíneos
Dieta
Gorduras/química
Linho/química
Lipídeos/sangue
Plantas Geneticamente Modificadas
[Mh] Termos MeSH secundário: Animais
Antioxidantes/análise
Colesterol/sangue
HDL-Colesterol/sangue
LDL-Colesterol/sangue
Contagem de Eritrócitos
Índices de Eritrócitos
Linho/genética
Genótipo
Promoção da Saúde
Hematócrito
Contagem de Leucócitos
Oxirredução
Coelhos
Sementes/química
Sementes/genética
Ácido alfa-Linolênico/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Cholesterol, HDL); 0 (Cholesterol, LDL); 0 (Fats); 0 (Lipids); 0RBV727H71 (alpha-Linolenic Acid); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160310
[St] Status:MEDLINE
[do] DOI:10.1002/jsfa.7705


  5 / 2992 MEDLINE  
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[PMID]:27904723
[Au] Autor:Ahn DK; Shin WS; Kim JW; Yi SM
[Ad] Endereço:Department of Orthopedic Surgery, Seoul Sacred Heart General Hospital, Seoul, Korea.
[Ti] Título:Why Cannot Suction Drains Prevent Postoperative Spinal Epidural Hematoma?
[So] Source:Clin Orthop Surg;8(4):407-411, 2016 Dec.
[Is] ISSN:2005-4408
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Postoperative spinal epidural hematoma (POSEH) is different from spontaneous or post-spinal procedure hematoma because of the application of suction drains. However, it appeared that suction drains were not effective for prevention of POSEH in previous studies. The purpose of this study was to test our hypothesis that POSEH can be caused by hypercoagulability. METHODS: This was an experimental study. One hundred fifty milliliters of blood was donated from each of the 12 consecutive patients who underwent spine surgery and infused into 3 saline bags of 50 mL each. One of the 3 bags in each set contained 5,000 units of thrombin. All of them were connected to 120 ± 30 mmHg vacuum suctions: drainage was started 8 minutes after connection to the vacuum system for 12 normal blood bags (BV8) and 12 thrombin-containing blood bags (TBV8) and 15 minutes after connection for the remaining 12 normal blood bags (BV15). The amount of initial and remaining hematoma at 20 minutes, 120 minutes, and 24 hours after vacuum application were measured by their weight (g). The primary endpoint was the difference between BV8 and TBV8. The secondary end point was the difference between BV8 and BV15. RESULTS: The remaining hematoma in TBV8 was significantly greater than that in BV8 at all measurement points: 46.3 ± 12.4 vs. 17.0 ± 1.3 ( = 0.000) at 20 minutes; 33.0 ± 8.2 vs. 16.3 ± 1.2 ( = 0.000) at 120 minutes; and 26.1 ± 4.0 vs. 15.8 ± 1.6 ( = 0.000) at 24 hours after vacuum application. The remaining hematoma of BV15 was significantly greater than that of BV8 at all measurement points: 30.0 ± 12.0 vs. 17.0 ± 1.3 ( = 0.002) at 20 minutes; 24.2 ± 7.6 vs. 16.3 ± 1.2 at 120 minutes ( = 0.002); and 22.2 ± 6.6 vs. 15.8 ± 1.6 ( = 0.004) at 24 hours after vacuum application. CONCLUSIONS: With a suction drain in place, the amount of remaining hematoma could be affected by coagulability. Thrombin-containing local hemostatics and the length of time elapsed before the commencement of suction resulted in hypercoagulability, indicating these two factors could be causes of POSEH.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos Sanguíneos
Drenagem/instrumentação
Hematoma Epidural Espinal
Modelos Biológicos
Complicações Pós-Operatórias
[Mh] Termos MeSH secundário: Idoso
Drenagem/métodos
Feminino
Hematoma Epidural Espinal/fisiopatologia
Hematoma Epidural Espinal/prevenção & controle
Seres Humanos
Masculino
Meia-Idade
Complicações Pós-Operatórias/fisiopatologia
Complicações Pós-Operatórias/prevenção & controle
Trombina/fisiologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.4.21.5 (Thrombin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161202
[St] Status:MEDLINE


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[PMID]:27633671
[Au] Autor:Lu Y; Wu Z; Song Z; Xiao P; Liu Y; Zhang P; You F
[Ad] Endereço:Key Laboratory of Experimental Marine Biology, National & Local Joint Engineering Laboratory of Ecological Mariculture, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science
[Ti] Título:Insight into the heat resistance of fish via blood: Effects of heat stress on metabolism, oxidative stress and antioxidant response of olive flounder Paralichthys olivaceus and turbot Scophthalmus maximus.
[So] Source:Fish Shellfish Immunol;58:125-135, 2016 Nov.
[Is] ISSN:1095-9947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:High temperature has direct confinement on fish survival and growth, especially under the background of global warming. Selection of fish line with heat resistance is an important means to address this problem. In the present study, we analyzed the difference in heat resistance between families of olive flounder Paralichthys olivaceus and turbot Scophthalmus maximus, two flatfish species occupying slightly different thermal niches. Then the chosen families were tested to determine their differential response to heat stress (ΔT = +8 °C and +12 °C) in blood, including anaerobic metabolism (lactate), oxidative stress (lipid peroxidation and protein carbonylation) and antioxidant enzymes. Results showed a difference in heat resistance between families of the two species. Among the chosen parameters, growth traits had a significant effect on contents of lactate and malondialdehyd (MDA), and activities of catalase (CAT) and glutathione S-transferase in flounder (P < 0.05), and on MDA content and CAT activity in turbot (P < 0.05). In comparison with heat-sensitive family of each species, levels of all studied parameters were lower and more stable in heat-resistant families after heat stress. What's more, heat resistance of fish significantly influenced contents of lactate and MDA and activity of CAT in flounder (P < 0.05), as well as contents of lactate, MDA and carbonyl and activity of superoxide dismutate (SOD) in turbot (P < 0.05). These results demonstrated that such physiological phenotypes as anaerobic metabolism, oxidative stress and antioxidant enzymes are good biomarkers of fish heat-resistance, being potentially valuable in fish breeding. However, these markers should be applied with more caution when there is a growth discrepancy between fish families.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos Sanguíneos
Metabolismo Energético
Linguados/fisiologia
Temperatura Alta
Estresse Oxidativo
Oxirredutases/metabolismo
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Análise Química do Sangue/veterinária
Ativação Enzimática/fisiologia
Linguados/sangue
Distribuição Aleatória
Termotolerância/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); EC 1.- (Oxidoreductases)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170923
[Lr] Data última revisão:
170923
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160917
[St] Status:MEDLINE


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[PMID]:27599220
[Au] Autor:Kish JL; McGuirk SM; Friedrichs KR; Peek SF
[Ad] Endereço:Departments of Medical Sciences and Pathobiological Sciences, School of Veterinary Medicine, 2015 Linden Drive West, University of Wisconsin-Madison, Madison, WI, 53706.
[Ti] Título:Defining colloid osmotic pressure and the relationship between blood proteins and colloid osmotic pressure in dairy cows and calves.
[So] Source:J Vet Emerg Crit Care (San Antonio);26(5):675-81, 2016 Sep.
[Is] ISSN:1476-4431
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To establish the reference interval for colloid osmotic pressure (COP) in neonatal and adult cattle and to investigate associations between COP and total protein, albumin, or globulin in the two populations sampled. DESIGN: Cross-sectional observational study. SETTING: Animals were sampled on commercial dairy farms in Southern Wisconsin, and samples were processed and analyzed in a clinical pathology laboratory at a university teaching hospital. ANIMALS: Forty adult lactating Holstein cows between 2 and 4 years of age and 40 healthy Holstein calves of both sexes between 2 and 7 days of age. INTERVENTIONS: Adult cows were sampled by coccygeal venipuncture into standard heparinized vacutainer tubes, calves were sampled by jugular venipuncture also into heparinized vacutainer tubes. MEASUREMENTS AND MAIN RESULTS: For adult cows, the mean COP was 22.52 mm Hg, with a standard deviation of 1.0. For calves, the mean COP was 19.6 mm Hg, with a standard deviation of 1.9. Good correlation was demonstrated in adults between COP and albumin concentrations (r(2) = 0.72) and between COP and both total protein concentration (r(2) = 0.74) and globulin (r(2) = 0.65) in calves. For adults, regression plots established best fit relationships of COP = 0.472 (albumin) + 6.49, whereas for calves, two regression equations could be described; COP = 0.305 (globulin) + 8.62, and 0.268 (total plasma protein) + 2.73. CONCLUSIONS: Suggested normal ranges (mean ± 2 standard deviations) for COP in adult lactating dairy cows and calves between 2 and 7 days of age were 21-25 mm Hg and 17-23 mm Hg, respectively.
[Mh] Termos MeSH primário: Animais Recém-Nascidos/sangue
Proteínas Sanguíneas/análise
Bovinos/sangue
Coloides/análise
[Mh] Termos MeSH secundário: Centros Médicos Acadêmicos
Animais
Fenômenos Fisiológicos Sanguíneos
Estudos Transversais
Indústria de Laticínios
Feminino
Lactação
Masculino
Pressão Osmótica
Valores de Referência
Wisconsin
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Blood Proteins); 0 (Colloids)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160907
[St] Status:MEDLINE
[do] DOI:10.1111/vec.12517


  8 / 2992 MEDLINE  
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[PMID]:27068991
[Au] Autor:Quinn JG; Tansey EA; Johnson CD; Roe SM; Montgomery LE
[Ad] Endereço:Centre for Biomedical Sciences Education, School of Medicine Dentistry and Biomedical Science, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom joe.quinn@qub.ac.uk.
[Ti] Título:Blood: tests used to assess the physiological and immunological properties of blood.
[So] Source:Adv Physiol Educ;40(2):165-75, 2016 Jun.
[Is] ISSN:1522-1229
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The properties of blood and the relative ease of access to which it can be retrieved make it an ideal source to gauge different aspects of homeostasis within an individual, form an accurate diagnosis, and formulate an appropriate treatment regime. Tests used to determine blood parameters such as the erythrocyte sedimentation rate, hemoglobin concentration, hematocrit, bleeding and clotting times, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, mean cell volume, and determination of blood groups are routinely used clinically, and deviations outside the normal range can indicate a range of conditions such as anemia, pregnancy, dehydration, overhydration, infectious disease, cancer, thyroid disease, and autoimmune conditions, to mention a few. As these tests can be performed relatively inexpensively and do not require high levels of technical expertise, they are ideally suited for use in the teaching laboratory, enabling undergraduate students to link theory to practice. The practicals described here permit students to examine their own blood and that of their peers and compare these with clinically accepted normal ranges. At the end of the practicals, students are required to answer a number of questions about their findings and to link abnormal values to possible pathological conditions by answering a series of questions based on their findings.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos Sanguíneos/imunologia
Educação em Saúde/métodos
Testes Hematológicos/métodos
Aprendizagem Baseada em Problemas/métodos
Estudantes de Ciências da Saúde
[Mh] Termos MeSH secundário: Sangue/imunologia
Sedimentação Sanguínea
Contagem de Eritrócitos/métodos
Índices de Eritrócitos/fisiologia
Hematócrito/métodos
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161231
[Lr] Data última revisão:
161231
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160413
[St] Status:MEDLINE
[do] DOI:10.1152/advan.00079.2015


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[PMID]:27051346
[Au] Autor:Jeong J; Park S; Jeong E; Kim N; Kim M; Jung Y; Cho Y; Lee K
[Ad] Endereço:College of Veterinary Medicine, Chonbuk National University Specialized Campus, Iksan 54596, Korea.
[Ti] Título:Time-dependent low-field MRI characteristics of canine blood: an in vitro study.
[So] Source:J Vet Sci;17(1):103-9, 2016 Mar.
[Is] ISSN:1976-555X
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:This study was conducted to assess time-sensitive magnetic resonance (MR) changes in canine blood using low-field MR. Arterial and venous blood samples were collected from eight healthy beagle dogs. Samples were placed in 5-mL tubes and imaged within 3 hours of collection at 1 day intervals from day 1 to day 30. The following sequences were used: T1-weighted (T1W), T2-weighted (T2W), fluid-attenuated inversion recovery (FLAIR), short tau inversion recovery (STIR), and T2-star gradient-echo (T2(*)-GRE). Visual comparison of the images revealed that four relatively homogenous blood clots and twelve heterogeneous blood clots developed. The margination of the clot and plasma changed significantly on day 2 and day 13. On day 2, heterogeneous blood clots were differentiated into 2 to 3 signal layers in the T2W, T1W, and especially the STIR images. Hypointense signal layers were also detected in the blood clots in STIR images, which have T2 hypo, FLAIR hypo, and T1 hyper intense signals. In all images, these signal layers remained relatively unchanged until day 13. Overall, the results suggest that hematomas are complex on low-field MRI. Accordingly, it may not be feasible to accurately characterize hemorrhages and predict clot age based on low-field MRI.
[Mh] Termos MeSH primário: Sangue/diagnóstico por imagem
Imagem por Ressonância Magnética
[Mh] Termos MeSH secundário: Animais
Coagulação Sanguínea
Fenômenos Fisiológicos Sanguíneos
Cães
Feminino
Hematoma/diagnóstico por imagem
Hemorragia/diagnóstico por imagem
Trombose/diagnóstico por imagem
Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160407
[St] Status:MEDLINE
[do] DOI:10.4142/jvs.2016.17.1.103


  10 / 2992 MEDLINE  
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[PMID]:26953500
[Au] Autor:Petrovic A; Krauskopf A; Hassler E; Stollberger R; Scheurer E
[Ad] Endereço:Ludwig Boltzmann Institute for Clinical-Forensic Imaging, Universitätsplatz 4/II, 8010 Graz, Austria; Institute of Medical Engineering, BioTechMed, Graz University of Technology, Stremayergasse 16/3, 8010 Graz, Austria.
[Ti] Título:Time related changes of T1, T2, and T2(*)(2) of human blood in vitro.
[So] Source:Forensic Sci Int;262:11-7, 2016 May.
[Is] ISSN:1872-6283
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:In view of a potential future use for dating hemorrhage in forensic medicine the correlation of MR relaxation parameters with time was evaluated in blood samples. A systematic relationship could be valuable for using MRI for estimating the age of hemorrhage and soft tissue hematomas particularly in clinical forensic medicine. Relaxation times T1, T2, and T2(*) of venous blood samples from 6 volunteers were measured using 3T MRI regularly up to 30 days. The time progression of the relaxation parameters was systematically analyzed and examined for possible interrelations. T2 initially decreased to a minimum, and then increased again (range 24-97ms), while T1 started with a plateau phase followed by an almost linear decrease (range 333-2153ms). T2(*) remained relatively constant during the entire investigation period. The higher the initial T2 was, the lower was its minimum, and the greater was the decrease of the associated T1. The inter- and intra-individual variability was relatively large, one reason being very likely the metabolic differences in the blood samples. The observed characteristic changes in blood samples over time measured by quantitative MR techniques add objective information in view of an estimation of the age of hemorrhage. However, in vivo studies will be needed to verify the data with respect to influencing metabolic factors.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos Sanguíneos
Imagem por Ressonância Magnética/métodos
[Mh] Termos MeSH secundário: Adulto
Feminino
Patologia Legal
Seres Humanos
Técnicas In Vitro
Masculino
Modelos Estatísticos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170202
[Lr] Data última revisão:
170202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160309
[St] Status:MEDLINE



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