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[PMID]:29385202
[Au] Autor:König M; Drewelies J; Norman K; Spira D; Buchmann N; Hülür G; Eibich P; Wagner GG; Lindenberger U; Steinhagen-Thiessen E; Gerstorf D; Demuth I
[Ad] Endereço:Lipid Clinic at the Interdisciplinary Metabolism Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.
[Ti] Título:Historical trends in modifiable indicators of cardiovascular health and self-rated health among older adults: Cohort differences over 20 years between the Berlin Aging Study (BASE) and the Berlin Aging Study II (BASE-II).
[So] Source:PLoS One;13(1):e0191699, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The last decades have seen great advances in the understanding, treatment, and prevention of cardiovascular disease (CVD). Although mortality rates due to CVD have declined significantly in the last decades, the burden of CVD is still high, particularly in older adults. This raises the question whether contemporary populations of older adults are experiencing better or worse objective as well as subjective health than earlier-born cohorts. The aim of this study was to examine differences in modifiable indicators of cardiovascular health (CVH), comparing data obtained 20 years apart in the Berlin Aging Study (BASE, 1990-93) and the Berlin Aging Study II (BASE-II, 2009-2014). METHODS: Serial cross-sectional analysis of 242 propensity-score-matched participants of BASE (born 1907-1922) and BASE-II (born 1925-1942). Body mass index (BMI), blood pressure, total cholesterol, glycated hemoglobin (HbA1c), diet, smoking and physical activity were operationalized according to the "Life's simple 7"(LS7) criteria of the American Heart Association. RESULTS: 121 matched pairs were identified based on age, sex, and education. In the later-born BASE-II sample, the mean LS7 score was significantly higher than in the earlier-born sample (7.8±1.8 vs. 6.4±2.1, p<0.001), indicating better CVH. In detail, diet, physical activity, smoking, cholesterol, and HbA1c were more favorable, whereas blood pressure was significantly higher in individuals from the later-born cohort. BMI did not differ significantly between the two matched samples. Notably, despite better CVH, later-born individuals (BASE-II) reported lower self-rated health, presumably because of higher health expectations. CONCLUSIONS: Overall, cardiovascular health was significantly better in the later-born cohort, but several notable exceptions exist.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Fenômenos Fisiológicos Cardiovasculares
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Envelhecimento/patologia
Berlim/epidemiologia
Pressão Sanguínea
Índice de Massa Corporal
Doenças Cardiovasculares/epidemiologia
Doenças Cardiovasculares/mortalidade
Colesterol/sangue
Estudos de Coortes
Estudos Transversais
Dieta
Exercício
Feminino
Hemoglobina A Glicada/metabolismo
Nível de Saúde
Seres Humanos
Masculino
Fatores de Risco
Autorrelato
Fumar
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Glycated Hemoglobin A); 0 (hemoglobin A1c protein, human); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191699


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[PMID]:29338025
[Au] Autor:Ward JL; Harrison K; Viner RM; Costello A; Heys M
[Ad] Endereço:UCL Institute of Child Health, University College London, London, United Kingdom.
[Ti] Título:Adolescent cohorts assessing growth, cardiovascular and cognitive outcomes in low and middle-income countries.
[So] Source:PLoS One;13(1):e0190443, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Life-course studies are needed to explore how exposures during adolescence, particularly puberty, contribute to later cardiovascular risk and cognitive health in low and middle-income countries (LMIC), where 90% of the world's young people live. The extent of any existing cohorts investigating these outcomes in LMIC has not previously been described. METHODS: We performed a systematic literature review to identify population cohort studies of adolescents in LMIC that assessed anthropometry and any of cardiovascular risk (blood pressure, physical activity, plasma glucose/lipid profile and substance misuse), puberty (age at menarche, Tanner staging, or other form of pubertal staging) or cognitive outcomes. Studies that recruited participants on the basis of a pre-existing condition or involved less than 500 young people were excluded. FINDINGS: 1829 studies were identified, and 24 cohorts fulfilled inclusion criteria based in Asia (10), Africa (6) and South / Central America (8). 14 (58%) of cohorts identified were based in one of four countries; India, Brazil, Vietnam or Ethiopia. Only 2 cohorts included a comprehensive cardiovascular assessment, tanner pubertal staging, and cognitive outcomes. CONCLUSION: Improved utilisation of existing datasets and additional cohort studies of adolescents in LMIC that collect contemporaneous measures of growth, cognition, cardiovascular risk and pubertal development are needed to better understand how this period of the life course influences future non-communicable disease morbidity and cognitive outcomes.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/epidemiologia
Fenômenos Fisiológicos Cardiovasculares
Transtornos Cognitivos/epidemiologia
Cognição
Crescimento
[Mh] Termos MeSH secundário: Adolescente
Brasil/epidemiologia
Estudos de Coortes
Etiópia/epidemiologia
Feminino
Seres Humanos
Índia/epidemiologia
Masculino
Puberdade
Vietnã/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190443


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[PMID]:28467921
[Au] Autor:Vega RB; Konhilas JP; Kelly DP; Leinwand LA
[Ad] Endereço:Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL 32827, USA.
[Ti] Título:Molecular Mechanisms Underlying Cardiac Adaptation to Exercise.
[So] Source:Cell Metab;25(5):1012-1026, 2017 May 02.
[Is] ISSN:1932-7420
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Exercise elicits coordinated multi-organ responses including skeletal muscle, vasculature, heart, and lung. In the short term, the output of the heart increases to meet the demand of strenuous exercise. Long-term exercise instigates remodeling of the heart including growth and adaptive molecular and cellular re-programming. Signaling pathways such as the insulin-like growth factor 1/PI3K/Akt pathway mediate many of these responses. Exercise-induced, or physiologic, cardiac growth contrasts with growth elicited by pathological stimuli such as hypertension. Comparing the molecular and cellular underpinnings of physiologic and pathologic cardiac growth has unveiled phenotype-specific signaling pathways and transcriptional regulatory programs. Studies suggest that exercise pathways likely antagonize pathological pathways, and exercise training is often recommended for patients with chronic stable heart failure or following myocardial infarction. Herein, we summarize the current understanding of the structural and functional cardiac responses to exercise as well as signaling pathways and downstream effector molecules responsible for these adaptations.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/fisiopatologia
Exercício/fisiologia
Coração/fisiopatologia
Redes e Vias Metabólicas
[Mh] Termos MeSH secundário: Animais
Doenças Cardiovasculares/genética
Doenças Cardiovasculares/metabolismo
Doenças Cardiovasculares/patologia
Fenômenos Fisiológicos Cardiovasculares
Sistema Cardiovascular/metabolismo
Sistema Cardiovascular/patologia
Sistema Cardiovascular/fisiopatologia
Redes Reguladoras de Genes
Coração/fisiologia
Seres Humanos
Miocárdio/metabolismo
Miocárdio/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


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[PMID]:29324835
[Au] Autor:Poleszczuk J; Debowska M; Dabrowski W; Wojcik-Zaluska A; Zaluska W; Waniewski J
[Ad] Endereço:Department for Mathematical Modeling of Physiological Processes, Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland.
[Ti] Título:Subject-specific pulse wave propagation modeling: Towards enhancement of cardiovascular assessment methods.
[So] Source:PLoS One;13(1):e0190972, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cardiovascular diseases are the leading cause of death worldwide. Pulse wave analysis (PWA) technique, which reconstructs and analyses aortic pressure waveform based on non-invasive peripheral pressure recording, became an important bioassay for cardiovascular assessment in a general population. The aim of our study was to establish a pulse wave propagation modeling framework capable of matching clinical PWA data from healthy individuals on a per-subject basis. Radial pressure profiles from 20 healthy individuals (10 males, 10 females), with mean age of 42 ± 10 years, were recorded using applanation tonometry (SphygmoCor, AtCor Medical, Australia) and used to estimate subject-specific parameters of mathematical model of blood flow in the system of fifty-five arteries. The model was able to describe recorded pressure profiles with high accuracy (mean absolute percentage error of 1.87 ± 0.75%) when estimating only 6 parameters for each subject. Cardiac output (CO) and stroke volume (SV) have been correctly identified by the model as lower in females than males (CO of 3.57 ± 0.54 vs. 4.18 ± 0.72 L/min with p-value < 0.05; SV of 49.5 ± 10.1 vs. 64.2 ± 16.8 ml with p-value = 0.076). Moreover, the model identified age related changes in the heart function, i.e. that the cardiac output at rest is maintained with age (r = 0.23; p-value = 0.32) despite the decreasing heart rate (r = -0.49; p-value < 0.05), because of the increase in stroke volume (r = 0.46; p-value < 0.05). Central PWA indices derived from recorded waveforms strongly correlated with those obtained using corresponding model-predicted radial waves (r > 0.99 and r > 0.97 for systolic (SP) and diastolic (DP) pressures, respectively; r > 0.77 for augmentation index (AI); all p-values < 0.01). Model-predicted central waveforms, however, had higher SP than those reconstructed by PWA using recorded radial waves (5.6 ± 3.3 mmHg on average). From all estimated subject-specific parameters only the time to the peak of heart ejection profile correlated with clinically measured AI. Our study suggests that the proposed model may serve as a tool to computationally investigate virtual patient scenarios mimicking different cardiovascular abnormalities. Such a framework can augment our understanding and help with the interpretation of PWA results.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos Cardiovasculares
Análise de Onda de Pulso
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190972


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[PMID]:29272287
[Au] Autor:Garcia-Martin E; Ruiz-de Gopegui E; León-Latre M; Otin S; Altemir I; Polo V; Larrosa JM; Cipres M; Casasnovas JA; Pablo LE
[Ad] Endereço:Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain.
[Ti] Título:Influence of cardiovascular condition on retinal and retinal nerve fiber layer measurements.
[So] Source:PLoS One;12(12):e0189929, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To assess changes in the retinal nerve fiber layer (RNFL) and macula in subjects with cardiovascular risk factors or subclinical ischemia. DESIGN: Prospective and observational study. METHODS: A total of 152 healthy men underwent cardiovascular examination, including quantification of subclinical atheroma plaques by artery ultrasound scans, blood analysis, and a complete ophthalmic evaluation, including spectral-domain optical coherence tomography. The variables registered in cardiovascular examination were quantification of classic major risk factors, subclinical atheroma plaques by artery ultrasound scans, and analytical records. The ophthalmic evaluation registered RNFL and macular thickness. RESULTS: Mean subject age was 51.27±3.71 years. The 40 subjects without classic cardiovascular risk factors did not show differences in RNFL and macular thicknesses compared with the 112 subjects with at least one risk factor (except in sector 9 that showed higher thicknesses in subjects with ≥1 risk factor). Comparison between the group of subjects with and without atheroma plaques revealed no differences in RNFL and macular thicknesses. The sub-analysis of subjects with subclinical atheroma plaques in the common carotid artery revealed a significant reduction in central macular thickness in the left eye compared with the right eye (p = 0.016), RNFL in the superior quadrant (p = 0.007), and the 11 o'clock sector (p = 0.020). Comparison between smokers and nonsmokers revealed that smokers had significant thinning of the central macular thickness (p = 0.034), the nasal RNFL quadrant (p = 0.006), and the 3 and 5 o'clock sectors (p = 0.016 and 0.009). CONCLUSIONS: Classic cardiovascular risk factors do not cause RNFL or macular thickness reduction, but tobacco smoking habit reduces nasal RNFL thickness. Subclinical atherosclerosis in the common carotid artery associates a reduction in central macular and nasal RNFL quadrant thicknesses in the left eye compared with the right eye.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos Cardiovasculares
Fibras Nervosas
Retina/anatomia & histologia
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171223
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189929


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[PMID]:29185590
[Au] Autor:Biagini S; Dale CS; Real JM; Moreira ES; Carvalho CRR; Schettino GPP; Wendel S; Azevedo LCP
[Ad] Endereço:Instituto de Ensino e Pesquisa, Hospital Sírio-Libanês, São Paulo, SP, Brasil.
[Ti] Título:Short-term effects of stored homologous red blood cell transfusion on cardiorespiratory function and inflammation: an experimental study in a hypovolemia model.
[So] Source:Braz J Med Biol Res;51(1):e6258, 2017 Nov 17.
[Is] ISSN:1414-431X
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The pathophysiological mechanisms associated with the effects of red blood cell (RBC) transfusion on cardiopulmonary function and inflammation are unclear. We developed an experimental model of homologous 14-days stored RBC transfusion in hypovolemic swine to evaluate the short-term effects of transfusion on cardiopulmonary system and inflammation. Sixteen healthy male anesthetized swine (68±3.3 kg) were submitted to controlled hemorrhage (25% of blood volume). Two units of non-filtered RBC from each animal were stored under blood bank conditions for 14 days. After 30 min of hypovolemia, the control group (n=8) received an infusion of lactated Ringer's solution (three times the removed volume). The transfusion group (n=8) received two units of homologous 14-days stored RBC and lactated Ringer's solution in a volume that was three times the difference between blood removed and blood transfusion infused. Both groups were followed up for 6 h after resuscitation with collection of hemodynamic and respiratory data. Cytokines and RNA expression were measured in plasma and lung tissue. Stored RBC transfusion significantly increased mixed oxygen venous saturation and arterial oxygen content. Transfusion was not associated with alterations on pulmonary function. Pulmonary concentrations of cytokines were not different between groups. Gene expression for lung cytokines demonstrated a 2-fold increase in mRNA level for inducible nitric oxide synthase and a 0.5-fold decrease in mRNA content for IL-21 in the transfused group. Thus, stored homologous RBC transfusion in a hypovolemia model improved cardiovascular parameters but did not induce significant effects on microcirculation, pulmonary inflammation and respiratory function up to 6 h after transfusion.
[Mh] Termos MeSH primário: Preservação de Sangue/métodos
Fenômenos Fisiológicos Cardiovasculares
Transfusão de Eritrócitos/métodos
Hipovolemia/terapia
Pneumonia/fisiopatologia
Fenômenos Fisiológicos Respiratórios
[Mh] Termos MeSH secundário: Animais
Preservação de Sangue/efeitos adversos
Citocinas/sangue
Modelos Animais de Doenças
Ensaio de Imunoadsorção Enzimática
Transfusão de Eritrócitos/efeitos adversos
Hemodinâmica
Masculino
Oxigênio/metabolismo
Reprodutibilidade dos Testes
Ressuscitação/métodos
Suínos
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); S88TT14065 (Oxygen)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE


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[PMID]:29173604
[Au] Autor:Pandey A; Suskin N; Poirier P
[Ad] Endereço:Cambridge Cardiac Care Centre, Cambridge, Ontario, Canada; Department of Medicine, Harvard Medical School, Boston, Massachusetts; University of Western Ontario, London, Ontario, Canada.
[Ti] Título:The Impact of Burst Exercise on Cardiometabolic Status of Patients Newly Diagnosed With Type 2 Diabetes.
[So] Source:Can J Cardiol;33(12):1645-1651, 2017 Dec.
[Is] ISSN:1916-7075
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The impact of burst high-intensity exercise on physiological, cardiometabolic, and biochemical variables compared with traditional moderate-intensity continuous exercise training (MICT) has yet to be assessed in patients with type 2 diabetes (T2D). We compared the impact of multiple short-duration, high-intensity burst exercise sessions to MICT on cardiometabolic variables in patients with T2D. METHODS: Forty newly diagnosed patients with T2D not receiving lipid lowering or hypoglycemic medications were randomized to 40 minutes of MICT (60% of maximal heart rate) 5 days per week or 3 continuous bursts of 12 minutes of high-intensity exercise (85% of maximal heart rate) 5 days per week for 3 months. Body mass index, hemoglobin A (HbA ), and lipid profile were assessed before and after 3 months of exercise training. RESULTS: Burst exercise resulted in greater body mass index reduction than did MICT (-2.1 ± 1.2 kg/m vs -0.7 ± 0.7 kg/m , respectively; P < 0.05). There was a greater reduction at 3 months (P < 0.05) in HbA levels in the burst exercise group (8.14% ± 0.49% to 7.32% ± 0.39%) compared with the MICT group (8.18% ± 0.35% to 7.94% ± 0.41%). Compared with MICT, burst exercise was associated with a greater reduction in low-density lipoprotein cholesterol (-11 vs -4%; P < 0.05) and a greater increase in high-density lipoprotein cholesterol (22% vs 3%; all P < 0.05). After 3 months, patients in the burst exercise group attained greater exercise time on the treadmill (exercise capacity) than did those prescribed MICT (6.87 ± 1.44 minutes vs 5.40 ± 1.96 minutes; P < 0.001). CONCLUSIONS: Findings from the current study support better cardiometabolic benefits of burst exercise compared with MICT over 3 months in patients with newly diagnosed T2D.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos Cardiovasculares
Diabetes Mellitus Tipo 2/reabilitação
Metabolismo Energético/fisiologia
Terapia por Exercício/métodos
Exercício/fisiologia
Resistência à Insulina/fisiologia
Consumo de Oxigênio/fisiologia
[Mh] Termos MeSH secundário: Idoso
Diabetes Mellitus Tipo 2/diagnóstico
Diabetes Mellitus Tipo 2/metabolismo
Teste de Esforço
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171204
[Lr] Data última revisão:
171204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:28726255
[Au] Autor:Çekiç EG; Filiz Basaran N; Dogan V; Biteker M
[Ad] Endereço:Department of Pharmacology, Faculty of Medicine, Mugla Sitki Koçman University, Mugla, Turkey.
[Ti] Título:Creatine supplementation on cardiac autonomic functions.
[So] Source:Pacing Clin Electrophysiol;40(9):1045, 2017 09.
[Is] ISSN:1540-8159
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Creatina
Suplementos Nutricionais
[Mh] Termos MeSH secundário: Sistema Nervoso Autônomo
Fenômenos Fisiológicos Cardiovasculares
Coração
Seres Humanos
Músculo Esquelético
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
MU72812GK0 (Creatine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1111/pace.13150


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[PMID]:28645930
[Au] Autor:Lucas-Herald AK; Alves-Lopes R; Montezano AC; Ahmed SF; Touyz RM
[Ad] Endereço:Developmental Endocrinology Research Group, Queen Elizabeth University Hospital Campus, 1345 Govan Road, Glasgow G51 4TF, U.K.
[Ti] Título:Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications.
[So] Source:Clin Sci (Lond);131(13):1405-1418, 2017 07 01.
[Is] ISSN:1470-8736
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The principle steroidal androgens are testosterone and its metabolite 5α-dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α-reductase. Through the classic pathway with androgens crossing the plasma membrane and binding to the androgen receptor (AR) or via mechanisms independent of the ligand-dependent transactivation function of nuclear receptors, testosterone induces genomic and non-genomic effects respectively. AR is widely distributed in several tissues, including vascular endothelial and smooth muscle cells. Androgens are essential for many developmental and physiological processes, especially in male reproductive tissues. It is now clear that androgens have multiple actions besides sex differentiation and sexual maturation and that many physiological systems are influenced by androgens, including regulation of cardiovascular function [nitric oxide (NO) release, Ca mobilization, vascular apoptosis, hypertrophy, calcification, senescence and reactive oxygen species (ROS) generation]. This review focuses on evidence indicating that interplay between genomic and non-genomic actions of testosterone may influence cardiovascular function.
[Mh] Termos MeSH primário: Androgênios/fisiologia
Fenômenos Fisiológicos Cardiovasculares/genética
[Mh] Termos MeSH secundário: Apoptose/fisiologia
Doenças Cardiovasculares/tratamento farmacológico
Sistema Cardiovascular/metabolismo
DNA/metabolismo
Genômica
Seres Humanos
Rim/fisiologia
Ereção Peniana/fisiologia
Espécies Reativas de Oxigênio/metabolismo
Receptores Androgênicos/metabolismo
Testosterona/fisiologia
Testosterona/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Androgens); 0 (Reactive Oxygen Species); 0 (Receptors, Androgen); 3XMK78S47O (Testosterone); 9007-49-2 (DNA)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170625
[St] Status:MEDLINE
[do] DOI:10.1042/CS20170090


  10 / 9195 MEDLINE  
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[PMID]:28634267
[Au] Autor:DuPont JJ; Jaffe IZ
[Ad] Endereço:Molecular Cardiology Research InstituteTufts Medical Center, Boston, MA, USA.
[Ti] Título:30 YEARS OF THE MINERALOCORTICOID RECEPTOR: The role of the mineralocorticoid receptor in the vasculature.
[So] Source:J Endocrinol;234(1):T67-T82, 2017 Jul.
[Is] ISSN:1479-6805
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Since the mineralocorticoid receptor (MR) was cloned 30 years ago, it has become clear that MR is expressed in extra-renal tissues, including the cardiovascular system, where it is expressed in all cells of the vasculature. Understanding the role of MR in the vasculature has been of particular interest as clinical trials show that MR antagonism improves cardiovascular outcomes out of proportion to changes in blood pressure. The last 30 years of research have demonstrated that MR is a functional hormone-activated transcription factor in vascular smooth muscle cells and endothelial cells. This review summarizes advances in our understanding of the role of vascular MR in regulating blood pressure and vascular function, and its contribution to vascular disease. Specifically, vascular MR contributes directly to blood pressure control and to vascular dysfunction and remodeling in response to hypertension, obesity and vascular injury. The literature is summarized with respect to the role of vascular MR in conditions including: pulmonary hypertension; cerebral vascular remodeling and stroke; vascular inflammation, atherosclerosis and myocardial infarction; acute kidney injury; and vascular pathology in the eye. Considerations regarding the impact of age and sex on the function of vascular MR are also described. Further investigation of the precise molecular mechanisms by which MR contributes to these processes will aid in the identification of novel therapeutic targets to reduce cardiovascular disease (CVD)-related morbidity and mortality.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos Cardiovasculares
Receptores de Mineralocorticoides/fisiologia
[Mh] Termos MeSH secundário: Animais
Regulação da Expressão Gênica/efeitos dos fármacos
Regulação da Expressão Gênica/fisiologia
Seres Humanos
Antagonistas de Receptores de Mineralocorticoides/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Mineralocorticoid Receptor Antagonists); 0 (Receptors, Mineralocorticoid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE
[do] DOI:10.1530/JOE-17-0009



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