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[PMID]:29381701
[Au] Autor:Galinovic I; Kochova E; Khalil A; Villringer K; Piper SK; Fiebach JB
[Ad] Endereço:Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Berlin, Germany.
[Ti] Título:The ratio between cerebral blood flow and Tmax predicts the quality of collaterals in acute ischemic stroke.
[So] Source:PLoS One;13(1):e0190811, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In acute ischemic stroke the status of collateral circulation is a critical factor in determining outcome. We propose a less invasive alternative to digital subtraction angiography for evaluating collaterals based on dynamic-susceptibility contrast magnetic resonance imaging. METHODS: Perfusion maps of Tmax and cerebral blood flow (CBF) were created for 35 patients with baseline occlusion of a major cerebral artery. Volumes of hypoperfusion were defined as having a Tmax delay of > 4 seconds (Tmax4s) and > 6 seconds (Tmax6s) and a CBF drop below 80% of healthy, contralateral tissue. For each patient a ratio between the volume of the CBF and the Tmax based perfusion deficit was calculated. Associations with collateral status and radiological outcome were assessed with the Mann-Whitney-U test, uni- and multivariable logistic regression analyses as well as area under the receiver-operator-characteristic (ROC) curve. RESULTS: The CBF/Tmax volume ratios were significantly associated with bad collateral status in crude logistic regression analysis as well as with adjustment for NIHSS at admission and baseline infarct volume (OR = 2.5 95% CI[1.2-5.4] p = 0.020 for CBF/Tmax 4s volume ratio and OR = 1.6 95% CI[1.0-2.6] p = 0.031 for CBF/Tmax6s volume ratio). Moreover, the ratios were significantly correlated to final infarct size (Spearman's rho = 0.711 and 0.619, respectively for the CBF/Tmax4s volume ratio and CBF/Tmax6s volume ration, all p<0.001). The ratios also had a high area under the ROC curve of 0.93 95%CI[0.86-1.00]) and 0.90 95%CI[0.80-1.00]respectively for predicting poor radiological outcome. CONCLUSIONS: In the setting of acute ischemic stroke the CBF/Tmax volume ratio can be used to differentiate between good and insufficient collateral circulation without the need for invasive procedures like conventional angiography.
[Mh] Termos MeSH primário: Isquemia Encefálica/fisiopatologia
Circulação Cerebrovascular
Circulação Colateral
Acidente Vascular Cerebral/fisiopatologia
[Mh] Termos MeSH secundário: Doença Aguda
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190811


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[PMID]:27776939
[Au] Autor:Fukui S; Tanaka H; Kobayashi K; Kajiyama T; Mitsuno M; Yamamura M; Ryomoto M; Miyamoto Y
[Ad] Endereço:Department of Cardiovascular Surgery, Hyogo College of Medicine, Nishinomiya, Japan. Electronic address: fukui0104@yahoo.co.jp.
[Ti] Título:Development of Collaterals to the Spinal Cord after Endovascular Stent Graft Repair of Thoracic Aneurysms.
[So] Source:Eur J Vasc Endovasc Surg;52(6):801-807, 2016 12.
[Is] ISSN:1532-2165
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: In thoracic and thoraco-abdominal aortic aneurysm repair, spinal cord injury (SCI) is devastating. Detection of the Adamkiewicz artery might be important for preventing SCI. Although thoracic endovascular stent grafts often occlude the segmental artery, the incidence of SCI in thoracic endovascular aortic repair is thought to be low compared with open repair. This study aimed to evaluate how the Adamkiewicz artery is supplied after segmental arteries are occluded by stent grafts. METHODS: From March 2007 to August 2015, 32 patients were enrolled whose segmental arteries that were connected to the Adamkiewicz arteries were occluded by stent grafts. Segmental arteries, Adamkiewicz arteries, collateral circulation into the Adamkiewicz arteries, and anterior spinal arteries were pre- and post-operatively evaluated by computed tomography angiography. RESULTS: Post-operatively, Adamkiewicz arteries were detected in 24 (75%) patients, except for two patients with paraplegia and six without paraplegia. Post-operative Adamkiewicz arteries were the same as pre-operative Adamkiewicz arteries, except for one Adamkiewicz artery that was located at two vertebral levels below the pre-operative level. SCI occurred in two (6.3%) patients. The distribution of feeding arteries into the Adamkiewicz artery post-operatively was divided into three patterns as follows: a segmental artery below the distal landing zone of the stent graft (53%), branches of the left subclavian artery (33%), and a branch of the left external iliac artery (13%). CONCLUSIONS: The length of the stent graft should be as short as possible. Blood supply to the left subclavian artery should be maintained because segmental arteries below the segmental artery occluded by the stent graft and branches of the left subclavian artery can become collaterals post-operatively.
[Mh] Termos MeSH primário: Aneurisma da Aorta Torácica/cirurgia
Implante de Prótese Vascular/instrumentação
Prótese Vascular
Circulação Colateral
Procedimentos Endovasculares/instrumentação
Medula Espinal/irrigação sanguínea
Stents
Artéria Subclávia/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Aneurisma da Aorta Torácica/diagnóstico por imagem
Aneurisma da Aorta Torácica/fisiopatologia
Aortografia/métodos
Implante de Prótese Vascular/efeitos adversos
Angiografia por Tomografia Computadorizada
Procedimentos Endovasculares/efeitos adversos
Feminino
Seres Humanos
Masculino
Meia-Idade
Tomografia Computadorizada Multidetectores
Desenho de Prótese
Fluxo Sanguíneo Regional
Estudos Retrospectivos
Fatores de Risco
Isquemia do Cordão Espinal/diagnóstico por imagem
Isquemia do Cordão Espinal/etiologia
Isquemia do Cordão Espinal/fisiopatologia
Artéria Subclávia/diagnóstico por imagem
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:29224761
[Au] Autor:Propst EJ; Zawawi F; Kirsch RE; Honjo O
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. Electronic address: Evan.propst@utoronto.ca.
[Ti] Título:Direct tracheobronchopexy via left lateral thoracotomy for severe tracheobronchomalacia.
[So] Source:Int J Pediatr Otorhinolaryngol;103:32-35, 2017 Dec.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:An infant with pulmonary atresia/ventricular septal defect/major aortopulmonary collateral arteries underwent unifocalization, ventriculoseptal defect closure and placement of a right ventricle to pulmonary artery conduit via median sternotomy. Aortopexy and pulmonary arteriopexy via redo sternotomy were insufficient to allow weaning of continuous positive airway pressure and he required direct tracheobronchopexy via left lateral thoracotomy to alleviate posterior trachealis intrusion along the length of the trachea and left main bronchus. He also underwent laryngotracheoplasty with placement of a posterior costal cartilage graft for bilateral vocal cord paralysis. The patient was weaned from positive pressure and discharged in stable condition.
[Mh] Termos MeSH primário: Brônquios/cirurgia
Toracotomia/métodos
Traqueia/cirurgia
Traqueobroncomalácia/cirurgia
[Mh] Termos MeSH secundário: Broncoscopia
Circulação Colateral
Comunicação Interventricular/cirurgia
Seres Humanos
Lactente
Masculino
Artéria Pulmonar/cirurgia
Atresia Pulmonar/cirurgia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


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[PMID]:28470330
[Au] Autor:Ajayi NO; Vanker EA; Satyapal KS
[Ad] Endereço:Department of Clinical Anatomy, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville, Durban, South Africa.
[Ti] Título:The role of coronary artery collaterals in the preservation of left ventricular function: a study to address a long-standing controversy.
[So] Source:Cardiovasc J Afr;28(2):81-85, 2017 Mar/Apr.
[Is] ISSN:1680-0745
[Cp] País de publicação:South Africa
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The functional significance of coronary artery collateral (CAC) vasculature in humans has been debated for decades and this has been compounded by the lack of a standard, systematic, objective method of grading and documenting CAC flow in man. CACs serve as alternative conduits for blood in obstructive coronary artery disease. This study aimed to evaluate the impact of CACs on left ventricular function in the presence of total coronary arterial occlusion. METHODS: The study group included the coronary angiographic records of 97 patients (mean age: 59 ± 8 years). CACs were graded from 0-3 based on the collateral connection between the donor and recipient arteries. Left ventricular function was computed from the ventriculogram and expressed as ejection fraction (EF). RESULTS: The mean EF of the patients with grades 0, 1, 2 and 3 CACs were calculated as 50.4, 47, 60.5 and 70%, respectively. A significant difference was recorded in the mean EF calculated for the different CAC grades (p = 0.001). There was a significant positive correlation (p < 0.001; r = 0.478) between the mean EF and the CAC grades. CONCLUSION: The patients with better coronary collateral grades had a higher mean EF. Therefore, as the grade of CACs increased, there was an improvement in their ability to preserve left ventricular function.
[Mh] Termos MeSH primário: Circulação Colateral
Circulação Coronária
Oclusão Coronária/fisiopatologia
Vasos Coronários/fisiopatologia
Volume Sistólico
Função Ventricular Esquerda
[Mh] Termos MeSH secundário: Idoso
Angiografia Coronária
Oclusão Coronária/diagnóstico por imagem
Vasos Coronários/diagnóstico por imagem
Feminino
Seres Humanos
Masculino
Meia-Idade
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.5830/CVJA-2016-054


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[PMID]:29016599
[Au] Autor:Liu Z; Pericak-Vance MA; Goldschmidt-Clermont P; Seo D; Wang L; Rundek T; Beecham GW
[Ad] Endereço:John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America.
[Ti] Título:Coronary collateralization shows sex and racial-ethnic differences in obstructive artery disease patients.
[So] Source:PLoS One;12(10):e0183836, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Coronary collateral circulation protects cardiac tissues from myocardial infarction damage and decreases sudden cardiac death. So far, it is unclear how coronary collateralization varies by race-ethnicity groups and by sex. METHODS: We assessed 868 patients with obstructive CAD. Patients were assessed for collateral grades based on Rentrop grading system, as well as other covariates. DNA samples were genotyped using the Affymetrix 6.0 genotyping array. To evaluate genetic contributions to collaterals, we performed admixture mapping using logistic regression with estimated local and global ancestry. RESULTS: Overall, 53% of participants had collaterals. We found difference between sex and racial-ethnic groups. Men had higher rates of collaterals than women (P-value = 0.000175). White Hispanics/Latinos showed overall higher rates of collaterals than African Americans and non-Hispanic Whites (59%, 50% and 48%, respectively, P-value = 0.017), and especially higher rates in grade 1 and grade 3 collateralization than the other two populations (P-value = 0.0257). Admixture mapping showed Native American ancestry was associated with the presence of collaterals at a region on chromosome 17 (chr17:35,243,142-41,251,931, ß = 0.55, P-value = 0.000127). African ancestry also showed association with collaterals at a different region on chromosome 17 (chr17: 32,266,966-34,463,323, ß = 0.38, P-value = 0.00072). CONCLUSIONS: In our study, collateralization showed sex and racial-ethnic differences in obstructive CAD patients. We identified two regions on chromosome 17 that were likely to harbor genetic variations that influenced collateralization.
[Mh] Termos MeSH primário: Aterosclerose/genética
Circulação Colateral/genética
Circulação Coronária/genética
Infarto do Miocárdio/genética
[Mh] Termos MeSH secundário: Adulto
Afroamericanos/genética
Idoso
Artérias/fisiopatologia
Aterosclerose/epidemiologia
Aterosclerose/fisiopatologia
Circulação Coronária/fisiologia
Grupos Étnicos
Grupo com Ancestrais do Continente Europeu/genética
Feminino
Genótipo
Hispano-Americanos/genética
Seres Humanos
Índios Norte-Americanos/genética
Modelos Logísticos
Masculino
Meia-Idade
Infarto do Miocárdio/epidemiologia
Infarto do Miocárdio/fisiopatologia
Fatores de Risco
Caracteres Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183836


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[PMID]:28954598
[Au] Autor:Ramírez-Senent B; Abadal JM; Vázquez E; Lago I; Gálvez E; Araujo MA; de la Quintana MI
[Ad] Endereço:1 Gregorio Marañon University Hospital, Madrid, Spain.
[Ti] Título:Endovascular Management of a Giant High-Flow Lower Limb Arteriovenous Malformation.
[So] Source:Vasc Endovascular Surg;51(8):572-576, 2017 Nov.
[Is] ISSN:1938-9116
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: High-flow arteriovenous malformations (AVMs) may pose a challenge for endovascular treatment due to high-flow rates. Incomplete treatment, recurrence, or even worsening can occur if a proper management is not performed. We report a case successfully treated with endovascular therapy. CASE REPORT: A 37-year-old male was referred to our hospital with a soft tumor in the left thigh, limb asymmetry and associated pain. Doppler ultrasound and magnetic resonance imaging showed an extensive high-flow AVM with a venous aneurysm of 40 mm diameter. Diagnostic angiography identified multiple feeding vessels from the profunda femoris and superficial femoral arteries. Two endovascular interventions were performed within 1 month, combining afferent vessel embolization and percutaneous thrombin injection into the nidus, to exclude the AVM. Two-year imaging follow-up revealed thrombosis of the malformation. The patient remained asymptomatic with normal thigh diameter. No complications were documented in any of the sessions. CONCLUSION: Endovascular therapy could be a safe and effective option for AVM as long as it includes not only feeding vessels embolization but also complete occlusion of the nidus.
[Mh] Termos MeSH primário: Malformações Arteriovenosas/cirurgia
Embolização Terapêutica
Procedimentos Endovasculares
Extremidade Inferior/irrigação sanguínea
[Mh] Termos MeSH secundário: Adulto
Angiografia Digital
Malformações Arteriovenosas/diagnóstico por imagem
Malformações Arteriovenosas/fisiopatologia
Velocidade do Fluxo Sanguíneo
Circulação Colateral
Seres Humanos
Angiografia por Ressonância Magnética
Masculino
Fluxo Sanguíneo Regional
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1177/1538574417731206


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[PMID]:28942284
[Au] Autor:Yan Y; Song D; Liu L; Meng X; Qi C; Wang J
[Ad] Endereço:Department of Cardiology, The Second Hospital, Jilin University, No. 218 Ziqiang Street, Changchun 130041, China.
[Ti] Título:The relationship of plasma decoy receptor 3 and coronary collateral circulation in patients with coronary artery disease.
[So] Source:Life Sci;189:84-88, 2017 Nov 15.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Previously, decoy receptor 3 (DcR3) was found to be a potential angiogenetic factor, while the relationship of DcR3 with coronary collateral circulation formation has not been investigated. In this study, we aimed to investigate whether plasma decoy receptor 3 levels was associated with CCC formation and evaluate its predictive power for CCC status in patients with coronary artery disease. METHODS: Among patients who underwent coronary angiography with coronary artery disease and had a stenosis of ≥90% were included in our study. Collateral degree was graded according to Rentrope Cohen classification. Patients with grade 2 or 3 collateral degree were enrolled in good CCC group and patients with grade 0 or 1 collateral degree were enrolled in poor CCC group. RESULTS: Plasma DcR3 level was significantly higher in good CCC group (328.00±230.82 vs 194.84±130.63ng/l, p<0.01) and positively correlated with Rentrope grade (p<0.01). In addition, plasma DcR3 was also positively correlated with VEGF-A. Both ROC (receiver operating characteristic curve) and multinomial logistical regression analysis showed that plasma DcR3 displayed potent predictive power for CCC status. CONCLUSIONS: Higher plasma DcR3 level was related to better CCC formation and displayed potent predictive power for CCC status.
[Mh] Termos MeSH primário: Circulação Colateral/fisiologia
Doença da Artéria Coronariana/fisiopatologia
Estenose Coronária/fisiopatologia
Membro 6b de Receptores do Fator de Necrose Tumoral/sangue
[Mh] Termos MeSH secundário: Idoso
Angiografia Coronária
Feminino
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Valor Preditivo dos Testes
Fator A de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Tumor Necrosis Factor, Member 6b); 0 (TNFRSF6B protein, human); 0 (Vascular Endothelial Growth Factor A)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170925
[St] Status:MEDLINE


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[PMID]:28902897
[Au] Autor:Hancock AM; Frostig RD
[Ad] Endereço:Department of Neurobiology and Behavior, University of California Irvine, Irvine, California, United States of America.
[Ti] Título:Testing the effects of sensory stimulation as a collateral-based therapeutic for ischemic stroke in C57BL/6J and CD1 mouse strains.
[So] Source:PLoS One;12(9):e0183909, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Utilizing a rat model of ischemic stroke, we have previously shown that sensory stimulation can completely protect rats from impending ischemic damage of cortex if this treatment is delivered within the first two hours post-permanent middle cerebral artery occlusion (pMCAo). The current study sought to extend our findings in rats to mice, which would allow new avenues of research not available in rats. Thus, young adult C57BL/6J and CD1 mice were tested for protection from ischemic stroke with the same protective sensory stimulation-based treatment. Cortical activity and blood flow were assessed with intrinsic signal optical imaging (ISOI) and laser speckle imaging (LSI), respectively, and histological analysis (TTC) was performed at the completion of the experiments. Standing in stark contrast to the positive results observed in rats, in both strains we found that there were no differences between treated and untreated mice at 24 hours post-pMCAo in terms of infarct volume, negative functional imaging results, and major reduction in retrograde collateral blood flow as compared to pre-pMCAo baseline and surgical controls. Also, no differences were found between the strains in terms of theses variables. Potential reasons for the differences between rats and mice are discussed.
[Mh] Termos MeSH primário: Isquemia Encefálica/terapia
Circulação Colateral/fisiologia
Estimulação Física/métodos
Acidente Vascular Cerebral/terapia
[Mh] Termos MeSH secundário: Animais
Isquemia Encefálica/etiologia
Córtex Cerebral/fisiopatologia
Modelos Animais de Doenças
Infarto da Artéria Cerebral Média/complicações
Infarto da Artéria Cerebral Média/terapia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Acidente Vascular Cerebral/etiologia
Acidente Vascular Cerebral/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183909


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[PMID]:28765286
[Au] Autor:Fan AP; Guo J; Khalighi MM; Gulaka PK; Shen B; Park JH; Gandhi H; Holley D; Rutledge O; Singh P; Haywood T; Steinberg GK; Chin FT; Zaharchuk G
[Ad] Endereço:From the Departments of Radiology (A.P.F., J.G., P.K.G., B.S., J.H.P., H.G., D.H., O.R., P.S., T.H., F.T.C., G.Z.) and Neurosurgery (G.K.S.), Stanford University, CA; and Global Applied Science Lab, GE Healthcare, Menlo Park, CA (M.M.K.). auddie@stanford.edu.
[Ti] Título:Long-Delay Arterial Spin Labeling Provides More Accurate Cerebral Blood Flow Measurements in Moyamoya Patients: A Simultaneous Positron Emission Tomography/MRI Study.
[So] Source:Stroke;48(9):2441-2449, 2017 Sep.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Arterial spin labeling (ASL) MRI is a promising, noninvasive technique to image cerebral blood flow (CBF) but is difficult to use in cerebrovascular patients with abnormal, long arterial transit times through collateral pathways. To be clinically adopted, ASL must first be optimized and validated against a reference standard in these challenging patient cases. METHODS: We compared standard-delay ASL (post-label delay=2.025 seconds), multidelay ASL (post-label delay=0.7-3.0 seconds), and long-label long-delay ASL acquisitions (post-label delay=4.0 seconds) against simultaneous [ O]-positron emission tomography (PET) CBF maps in 15 Moyamoya patients on a hybrid PET/MRI scanner. Dynamic susceptibility contrast was performed in each patient to identify areas of mild, moderate, and severe time-to-maximum (Tmax) delays. Relative CBF measurements by each ASL scan in 20 cortical regions were compared with the PET reference standard, and correlations were calculated for areas with moderate and severe Tmax delays. RESULTS: Standard-delay ASL underestimated relative CBF by 20% in areas of severe Tmax delays, particularly in anterior and middle territories commonly affected by Moyamoya disease ( <0.001). Arterial transit times correction by multidelay acquisitions led to improved consistency with PET, but still underestimated CBF in the presence of long transit delays ( =0.02). Long-label long-delay ASL scans showed the strongest correlation relative to PET, and there was no difference in mean relative CBF between the modalities, even in areas of severe delays. CONCLUSIONS: Post-label delay times of ≥4 seconds are needed and may be combined with multidelay strategies for robust ASL assessment of CBF in Moyamoya disease.
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Circulação Cerebrovascular
Doença de Moyamoya/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Encéfalo/irrigação sanguínea
Circulação Colateral
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Imagem Multimodal
Radioisótopos de Oxigênio
Tomografia por Emissão de Pósitrons
Marcadores de Spin
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oxygen Radioisotopes); 0 (Spin Labels)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.117.017773


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[PMID]:28715592
[Au] Autor:Yu PK; McAllister IL; Morgan WH; Cringle SJ; Yu DY
[Ad] Endereço:Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, Australia 2Lions Eye Institute, The University of Western Australia, Perth, Australia.
[Ti] Título:Inter-Relationship of Arterial Supply to Human Retina, Choroid, and Optic Nerve Head Using Micro Perfusion and Labeling.
[So] Source:Invest Ophthalmol Vis Sci;58(9):3565-3574, 2017 Jul 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: The prevailing view is that the human retina is supplied by the central retinal artery (CRA), the short posterior ciliary arteries (SPCAs) support the choroid, and both the CRA and the SPCAs are so-called "end artery" systems. In this study, we investigate whether vascular connections among the retina, choroid, and the optic nerve head (ONH) exist, using selective cannulation and microperfusion-labeling techniques. Methods: The CRA and/or one or more of the SPCAs were selected for cannulation in 18 human donor eyes. Fluorescent probes with different excitation wavelengths were perfused through different arteries on the same eye to distinguish the supply sources of different vascular beds. After labeling and fixation, the ONH region was dissected either longitudinally or transversely as thick sections for confocal microscopy. Retina, choroid, and ONH were imaged from whole-mount specimens. Results: Probes perfused through the CRA or the SPCA alone labeled the microvessels in the retina, choroid, and ONH regions, as well as the optic nerve trunk. The vessels of the lamina cribrosa and the optic nerve trunk were labeled when probes were perfused through the SPCA. Perfusion through both the CRA and SPCA produced double labeling of vessels in the retina, the choroid, and the ONH. Conclusions: The results indicate an inter-relationship of arterial supply to the retina, choroid, and ONH in the human eye. This has important implications in understanding clinical observations and disease mechanisms such as that of glaucoma and ischemic optic nerve disease.
[Mh] Termos MeSH primário: Corioide/irrigação sanguínea
Artérias Ciliares/fisiologia
Disco Óptico/irrigação sanguínea
Retina/fisiologia
Artéria Retiniana/fisiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Cateterismo
Artérias Ciliares/anatomia & histologia
Circulação Colateral
Bancos de Olhos
Feminino
Corantes Fluorescentes
Seres Humanos
Masculino
Microscopia Confocal
Meia-Idade
Imagem de Perfusão
Artéria Retiniana/anatomia & histologia
Doadores de Tecidos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluorescent Dyes)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22191



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