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[PMID]:27810156
[Au] Autor:Takatsuki S; Nakayama T; Ikehara S; Matsuura H; Ivy DD; Saji T
[Ad] Endereço:Department of Pediatrics, Toho University Omori Medical Center, Tokyo, Japan.
[Ti] Título:Pulmonary Arterial Capacitance Index Is a Strong Predictor for Adverse Outcome in Children with Idiopathic and Heritable Pulmonary Arterial Hypertension.
[So] Source:J Pediatr;180:75-79.e2, 2017 Jan.
[Is] ISSN:1097-6833
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To evaluate the clinical utility of pulmonary artery capacitance index (PACi) in the assessment of disease severity and prognostic value in children with idiopathic and heritable pulmonary arterial hypertension (PAH). STUDY DESIGN: PACi is defined as the ratio of stroke volume index over pulmonary pulse pressure. A retrospective study was performed to compare PACi, brain natriuretic peptide (BNP), 6-minute walk distance, New York Heart association (NYHA) functional class, and adverse outcomes (hospitalization due to heart failure, lung transplantation, and cardiac mortality) in 72 Japanese children (10 ± 3.6 years) with idiopathic and heritable PAH. RESULTS: PACi had significant correlations with pulmonary vascular resistance index (r =-0.73, P < .0001), BNP levels (r = -0.40, P = .0008), and 6-minute walk distance (r = 0.57, P < .05). Statistically significant differences in PACi were observed between NYHA functional class II vs combined III and IV (median; 1.1 vs 0.6 mL/mm Hg/m , respectively, P < .05). There were 25 of 72 (35%) children who had an adverse event including initiation of hospitalization due to heart failure, lung transplantation, and death. Cumulative event-free survival rate was significantly lower when PACi was <0.85 mL/mm Hg/m (log-rank test, P < .0001). CONCLUSIONS: PACi correlated with BNP and NYHA functional class and may serve as a strong prognostic marker in children with idiopathic and heritable PAH.
[Mh] Termos MeSH primário: Hipertensão Pulmonar Primária Familiar/fisiopatologia
Artéria Pulmonar/fisiopatologia
Capacitância Vascular
[Mh] Termos MeSH secundário: Criança
Feminino
Seres Humanos
Masculino
Valor Preditivo dos Testes
Prognóstico
Estudos Retrospectivos
Índice de Gravidade de Doença
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE


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[PMID]:27875533
[Au] Autor:Sugimoto K; Yoshihisa A; Nakazato K; Jin Y; Suzuki S; Yokokawa T; Misaka T; Yamaki T; Kunii H; Suzuki H; Saitoh SI; Takeishi Y
[Ad] Endereço:Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.
[Ti] Título:Pulmonary Arterial Capacitance Predicts Cardiac Events in Pulmonary Hypertension Due to Left Heart Disease.
[So] Source:PLoS One;11(11):e0165603, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Although pulmonary hypertension due to left heart disease (LHD-PH) accounts for the largest proportion of pulmonary hypertension, few reports on the epidemiological analysis of LHD-PH exist. Recently, pulmonary arterial capacitance (PAC) has attracted attention as a possible factor of right ventricular afterload along with pulmonary vascular resistance. We therefore investigated the clinical significance of PAC in LHD-PH. METHODS: The subject consisted of 252 LHD-PH patients (145 men, mean age 63.4 ± 14.7 years) diagnosed by right heart catheterization. PAC was estimated by the ratio between stroke volume and pulmonary arterial pulse pressure. Patients were classified into four groups according to the PAC (1st quartile was 0.74 to 1.76 ml/mmHg, the 2nd quartile 1.77 to 2.53 ml/mmHg, the 3rd quartile 2.54 to 3.59 ml/mmHg, and the 4th quartile 3.61 to 12.14 ml/mmHg). The end-points were defined as rehospitalization due to worsening heart failure and/or cardiac death. The Cox proportional hazard regression model was used to determine what variables were associated with cardiac events. RESULTS: The patients in the 1st quartile had the lowest cardiac index and stroke volume index, and the highest mean pulmonary arterial pressure, mean pulmonary capillary wedge pressure, and pulmonary vascular resistance compared with the 2nd, 3rd, and 4th quartiles. Fifty-four patients experienced cardiac events during the follow-up period (median 943 days). The event-free rate of the 1st quartile was significantly lower than that of the 3rd and 4th quartiles (66.7% vs 82.5% [3rd quartile], P = 0.008; and 92.1% [4th quartile], P < 0.001). The Cox hazard analysis revealed that PAC was significantly associated with cardiac events (HR 0.556, 95% CI 0.424-0.730, P < 0.001). CONCLUSION: PAC is useful in the prediction of cardiac event risk in LHD-PH patients.
[Mh] Termos MeSH primário: Síndrome Coronariana Aguda/fisiopatologia
Insuficiência Cardíaca/fisiopatologia
Hipertensão Pulmonar/fisiopatologia
Artéria Pulmonar/fisiopatologia
Volume Sistólico
Capacitância Vascular
[Mh] Termos MeSH secundário: Síndrome Coronariana Aguda/etiologia
Idoso
Feminino
Seguimentos
Insuficiência Cardíaca/etiologia
Seres Humanos
Hipertensão Pulmonar/complicações
Masculino
Meia-Idade
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161123
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0165603


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[PMID]:27671175
[Au] Autor:Chaudhri MS; Shah MU; Asghar MI; Siddiqi R; Janjua AM; Iqbal A
[Ad] Endereço:Department of Cardiac Surgery,Armed Forces Institute of Cardiology and National Institute of Heart Diseases (AFIC-NIHD), Rawalpindi.
[Ti] Título:Skeletonization of Left Internal Mammary Artery in Coronary Artery Bypass Grafting.
[So] Source:J Coll Physicians Surg Pak;26(9):736-9, 2016 Sep.
[Is] ISSN:1681-7168
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare mean per-operative flow capacity between skeletonized and pedicled left internal mammary artery (LIMA) in patients undergoing coronary artery bypass grafting (CABG) surgery. STUDY DESIGN: Randomized control trial. PLACE AND DURATION OF STUDY: Department of Cardiac Surgery, Armed Forces Institute of Cardiology and National Institute of Heart Diseases (AFIC-NIHD), Rawalpindi, Pakistan from February to August, 2013. METHODOLOGY: Patients undergoing CABG for coronary artery disease, under 80 years, excluded by the exclusion criteria; and fulfilling the inclusion criteria were randomly assigned to two groups of 70 each. One group underwent skeletonized and the other underwent pedicled technique of LIMAharvesting. Free flow was checked just before anastamosis of each LIMAto the LAD, manually in blood flow in ml per minute during cardiopulmonary bypass by allowing it to bleed into a 100 ml container over 20 seconds. Aspecialized proforma was used to record the age, gender, weight, disease, type of IMA used, and free flow of the IMA. Data was analyzed using SPSS 18. RESULTS: The mean age of the patients was 57.16 years in 40 patients, ranging from 36 to 75 years. Disease pattern analysis showed 5%, 10.7% and 84.3% single, double and triple vessel coronary artery disease, respectively. There was significantly higher free flow in the skeletonized group than the pedicled group (p=0.04). CONCLUSION: Skeletonized IMAhad superior flow to pedicled IMAin addition to its traditional proven advantages, which justifies its further use as a conduit for myocardial revascularization.
[Mh] Termos MeSH primário: Ponte de Artéria Coronária/métodos
Doença da Artéria Coronariana/cirurgia
Anastomose de Artéria Torácica Interna-Coronária/métodos
Artéria Torácica Interna/cirurgia
Fluxo Sanguíneo Regional/fisiologia
Coleta de Tecidos e Órgãos/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Ponte Cardiopulmonar
Estudos de Coortes
Doença da Artéria Coronariana/complicações
Doença da Artéria Coronariana/fisiopatologia
Feminino
Seres Humanos
Masculino
Artéria Torácica Interna/fisiopatologia
Meia-Idade
Paquistão
Compostos Radiofarmacêuticos
Resultado do Tratamento
Capacitância Vascular/fisiologia
Grau de Desobstrução Vascular/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Radiopharmaceuticals)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160928
[St] Status:MEDLINE
[do] DOI:2425


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[PMID]:26414317
[Au] Autor:Van Iterson EH; Snyder EM; Johnson BD; Olson TP
[Ad] Endereço:1Department of Kinesiology, University of Minnesota, Minneapolis, MN; 2Cardiovascular Medicine Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and 3Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN.
[Ti] Título:Influence of the Metaboreflex on Pulmonary Vascular Capacitance in Heart Failure.
[So] Source:Med Sci Sports Exerc;48(3):353-62, 2016 Mar.
[Is] ISSN:1530-0315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: An impaired metaboreflex is associated with abnormal ventilatory and peripheral vascular function in heart failure (HF), whereas its influence on cardiac function or pulmonary vascular pressure remains unclear. We aimed to assess whether metabolite-sensitive neural feedback (metaboreflex) from locomotor muscles via postexercise regional circulatory occlusion (RCO) attenuates pulmonary vascular capacitance (GXCAP) and/or circulatory power (CircP) in patients with HF. METHODS: Eleven patients with HF (NYHA class, I/II; ages, 51 ± 15 yr; ejection fraction, 32% ± 9%) and 11 age- and gender-matched controls (ages, 43 ± 9 yr) completed three cycling sessions (4 min, 60% peak oxygen uptake (VË™O2)). Session 1 was a control trial including normal recovery (NR). Session 2 or 3 included bilateral upper thigh pressure tourniquets inflated suprasystolic at end of exercise (RCO) for 2-min recovery with or without inspired CO2 (RCO + CO2) (randomized). Mean arterial pressure, HR, and VË™O2 were continuously measured. Estimates of central hemodynamics; CircP = (VË™O2 × mean arterial pressure)/weight; oxygen pulse index (O2pulseI = (VË™O2/HR)/body surface area); and GXCAP = O2pulseI × end-tidal partial pressure CO2 were calculated. RESULTS: At rest and end of exercise, CircP and GXCAP were lower in HF versus those in controls (P < 0.05), with no differences between transients (P > 0.05). At 2-min recovery, GXCAP was lower during RCO versus that during NR in both groups (72 ± 23 vs 98 ± 20 and 73 ± 34 vs 114 ± 35 mL·beat·mm Hg·m, respectively; P < 0.05), whereas CircP did not differ between transients (P > 0.05). Differences (% and Δ) between baseline and 2-min recovery among transients suggest that metaboreflex attenuates GXCAP in HF. Differences (% and Δ) between baseline and 2-min recovery among transients suggest that metaboreflex may attenuate CircP in controls. CONCLUSIONS: The present observations suggest that locomotor muscle metaboreflex activation may influence CircP in controls but not in HF. However, metaboreflex activation may evoke decreases in GXCAP (increased pulmonary vascular pressures) in HF and controls.
[Mh] Termos MeSH primário: Exercício/fisiologia
Insuficiência Cardíaca/fisiopatologia
Capacitância Vascular
[Mh] Termos MeSH secundário: Adulto
Idoso
Pressão Sanguínea
Dióxido de Carbono/análise
Estudos de Casos e Controles
Teste de Esforço
Feminino
Hemodinâmica
Seres Humanos
Masculino
Meia-Idade
Oxigênio/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
142M471B3J (Carbon Dioxide); S88TT14065 (Oxygen)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170301
[Lr] Data última revisão:
170301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150929
[St] Status:MEDLINE
[do] DOI:10.1249/MSS.0000000000000775


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[PMID]:26364865
[Au] Autor:Yan L; Liu CY; Smith RX; Jog M; Langham M; Krasileva K; Chen Y; Ringman JM; Wang DJJ
[Ad] Endereço:Laboratory of FMRI Technology (LOFT), Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: lryan737@gmail.com.
[Ti] Título:Assessing intracranial vascular compliance using dynamic arterial spin labeling.
[So] Source:Neuroimage;124(Pt A):433-441, 2016 Jan 01.
[Is] ISSN:1095-9572
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vascular compliance (VC) is an important marker for a number of cardiovascular diseases and dementia, which is typically assessed in the central and peripheral arteries indirectly by quantifying pulse wave velocity (PWV), and/or pulse pressure waveform. To date, very few methods are available for the quantification of intracranial VC. In the present study, a novel MRI technique for in-vivo assessment of intracranial VC was introduced, where dynamic arterial spin labeling (ASL) scans were synchronized with the systolic and diastolic phases of the cardiac cycle. VC is defined as the ratio of change in arterial cerebral blood volume (ΔCBV) and change in arterial pressure (ΔBP). Intracranial VC was assessed in different vascular components using the proposed dynamic ASL method. Our results show that VC mainly occurs in large arteries, and gradually decreases in small arteries and arterioles. The comparison of intracranial VC between young and elderly subjects shows that aging is accompanied by a reduction of intracranial VC, in good agreement with the literature. Furthermore, a positive association between intracranial VC and cerebral perfusion measured using pseudo-continuous ASL with 3D GRASE MRI was observed independent of aging effects, suggesting loss of VC is associated with a decline in perfusion. Finally, a significant positive correlation between intracranial and central (aortic arch) VC was observed using an ungated phase-contrast 1D projection PWV technique. The proposed dynamic ASL method offers a promising approach for assessing intracranial VC in a range of cardiovascular diseases and dementia.
[Mh] Termos MeSH primário: Encéfalo/irrigação sanguínea
Encéfalo/fisiologia
Eletrocardiografia/métodos
Imagem por Ressonância Magnética/métodos
Capacitância Vascular
[Mh] Termos MeSH secundário: Adulto
Pressão Arterial
Artérias/fisiologia
Arteríolas/fisiologia
Complacência (Medida de Distensibilidade)
Feminino
Seres Humanos
Masculino
Meia-Idade
Análise de Onda de Pulso
Marcadores de Spin
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Spin Labels)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170924
[Lr] Data última revisão:
170924
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150915
[St] Status:MEDLINE


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[PMID]:26315797
[Au] Autor:Cheng CP; Taylor CA; Dalman RL
[Ad] Endereço:Department of Surgery, Stanford University, Stanford, CA. Electronic address: cpc@stanford.edu.
[Ti] Título:Abdominal Aortic Hemodynamics in Intermittent Claudication Patients at Rest and during Dynamic Pedaling Exercise.
[So] Source:Ann Vasc Surg;29(8):1516-23, 2015 Nov.
[Is] ISSN:1615-5947
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Lower-extremity exercise has been shown to eliminate adverse hemodynamics conditions, such as low and oscillating blood flow and wall shear stress, in the abdominal aortas of healthy young and older adults. METHODS: We use cine phase-contrast magnetic resonance imaging and a custom MRI-compatible exercise cycle to quantify hemodynamic changes because of pedaling exercise in patients diagnosed with intermittent claudication. RESULTS: With only an average heart increase of 35 ± 18% and exercise workload of 36 ± 16 watts, the patients experienced approximately 3- and 6-fold increases in blood flow, and 4- and 16-fold increases in wall shear stress at the supraceliac and infrarenal aortic locations, respectively. Also, all oscillations in flow and shear stress at rest were eliminated with exercise. CONCLUSIONS: Claudication patients experience 3- to 4-fold lower oscillations in flow and shear stress at rest as compared with healthy age-matched controls, likely because of reduced distal arterial compliance as a result of distal atherosclerosis. The magnitude of flow and shear oscillatory indices may be good indicators of distal arterial compliance and health, and may provide predictive power for the efficacy of focal interventions.
[Mh] Termos MeSH primário: Aorta Abdominal/fisiopatologia
Exercício/fisiologia
Claudicação Intermitente/fisiopatologia
Fluxo Sanguíneo Regional/fisiologia
Descanso/fisiologia
[Mh] Termos MeSH secundário: Idoso
Estudos de Casos e Controles
Complacência (Medida de Distensibilidade)/fisiologia
Teste de Esforço
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Capacitância Vascular/fisiologia
Resistência Vascular/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170412
[Lr] Data última revisão:
170412
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150829
[St] Status:MEDLINE


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[PMID]:26310984
[Au] Autor:Van Iterson EH; Snyder EM; Joyner MJ; Johnson BD; Olson TP
[Ad] Endereço:Department of Kinesiology, University of Minnesota, Cooke Hall, 1900 University Ave. SE, Minneapolis, MN 55455, USA. Electronic address: vanit001@umn.edu.
[Ti] Título:Intrathecal fentanyl blockade of afferent neural feedback from skeletal muscle during exercise in heart failure patients: Influence on circulatory power and pulmonary vascular capacitance.
[So] Source:Int J Cardiol;201:384-93, 2015 Dec 15.
[Is] ISSN:1874-1754
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Secondary pulmonary hypertension is common in heart failure (HF) patients. We hypothesized that inhibition of feedback from locomotor muscle group III/IV neurons contributes to reduced pulmonary vascular pressures independent of changes in cardiac function during exercise in HF. METHODS: 9 HF patients (ages, 60 ± 2; EF, 26.7 ± 1.9%; New York Heart Association classes, I-III) and 9 age/gender matched controls (ages, 63 ± 2) completed five-minutes of constant-load cycling (65% Workloadpeak) with intrathecal fentanyl or placebo on randomized separate days. Mean arterial pressure (MAP), heart rate (HR), end-tidal partial pressure of CO2 (PETCO2), and oxygen consumption (VO2) were measured at rest and exercise. Non-invasive surrogates for cardiac power (circulatory power, CircP=VO2 × MAP), stroke volume (oxygen pulse, O2pulse=VO2/HR), and pulmonary arterial pressure (GXCAP=O2pulse × PETCO2) were calculated. RESULTS: At rest and end-exercise, differences between fentanyl versus placebo were not significant for CircP in HF or controls. Differences between fentanyl versus placebo for GXCAP were not significant at rest in HF or controls. At end-exercise, GXCAP was significantly higher with fentanyl versus placebo in HF (691 ± 59 versus 549 ± 38 mL/beat × mmHg), but not controls (536 ± 59 versus 474 ± 43 mL/beat × mmHg). Slopes (rest to end-exercise) for GXCAP were significantly higher with fentanyl versus placebo in HF (95.1 ± 9.8 versus 71.6 ± 6.0 mL/beat × mmHg), but not controls (74.3 ± 9.5 versus 60.8 ± 6.5 mL/beat × mmHg). CircP slopes did not differ between fentanyl versus placebo in HF or controls (p>0.05). CONCLUSION: We conclude that feedback from locomotor muscle group III/IV neurons may evoke increases in pulmonary vascular pressures independent of changes in cardiac function during exercise in HF.
[Mh] Termos MeSH primário: Analgésicos Opioides/administração & dosagem
Exercício/fisiologia
Fentanila/administração & dosagem
Insuficiência Cardíaca/fisiopatologia
Músculo Esquelético/efeitos dos fármacos
Músculo Esquelético/inervação
Neurônios Aferentes/efeitos dos fármacos
[Mh] Termos MeSH secundário: Idoso
Analgésicos Opioides/efeitos adversos
Estudos Cross-Over
Eletrocardiografia
Feminino
Fentanila/efeitos adversos
Seres Humanos
Hipertensão Pulmonar/fisiopatologia
Injeções Espinhais
Masculino
Meia-Idade
Método Simples-Cego
Capacitância Vascular/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Analgesics, Opioid); UF599785JZ (Fentanyl)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150828
[St] Status:MEDLINE


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[PMID]:25388783
[Au] Autor:Dragu R; Rispler S; Habib M; Sholy H; Hammerman H; Galie N; Aronson D
[Ad] Endereço:Department of Cardiology, Rambam Health Care Campus and the Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
[Ti] Título:Pulmonary arterial capacitance in patients with heart failure and reactive pulmonary hypertension.
[So] Source:Eur J Heart Fail;17(1):74-80, 2015 Jan.
[Is] ISSN:1879-0844
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: Reactive pulmonary hypertension (PH) is a severe form of PH secondary to left-sided heart failure (HF). Given the structural and functional abnormalities in the pulmonary vasculature that occur in reactive PH, we hypothesized that pulmonary artery capacitance (PAC) may be profoundly affected, with implications for clinical outcome. METHODS AND RESULTS: We studied 393 HF patients of whom 124 (32%) were classified as having passive PH and 140 (36%) as having reactive PH, and 91 patients with pulmonary arterial hypertension (PAH). Mean PAC was highest in patients without PH (4.5 ± 2.1 mL/mmHg), followed by the passive PH group (2.8 ± 1.4 mL/mmHg) and was lowest in those with reactive PH (1.8 ± 0.7 mL/mmHg) (P = 0.0001). PAC and pulmonary vascular resistance (PVR) fitted well to a hyperbolic inverse relationship (PAC = 0.25/PVR, R(2) = 0.70), with reactive PH patients dispersed almost predominantly on the flat part of the curve where a reduction in PVR is associated with a small improvement in PAC. Elevated PCWP was associated with a significant lowering of PAC for any PVR (P = 0.036). During a median follow-up of 31 months, both reactive PH [hazard ratio (HR) 2.59, 95% confidence interval (CI) 1.14-4.46, P = 0.02] and reduced PAC (HR 0.72 per 1 mL/mmHg increase, 95% CI 0.59-0.88, P = 0.001) were independent predictors of mortality. CONCLUSIONS: The development of reactive PH is associated with a marked reduction in PAC. PAC is a strong independent haemodynamic marker of mortality in HF and may contribute to the increased mortality associated with reactive PH.
[Mh] Termos MeSH primário: Insuficiência Cardíaca/fisiopatologia
Hipertensão Pulmonar/fisiopatologia
Artéria Pulmonar/fisiopatologia
Capacitância Vascular
[Mh] Termos MeSH secundário: Idoso
Cateterismo Cardíaco
Estudos de Casos e Controles
Feminino
Insuficiência Cardíaca/complicações
Seres Humanos
Hipertensão Pulmonar/etiologia
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150119
[Lr] Data última revisão:
150119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141113
[St] Status:MEDLINE
[do] DOI:10.1002/ejhf.192


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[PMID]:25365168
[Au] Autor:Kasai H; Sugiura T; Tanabe N; Sakurai Y; Yahaba M; Matsuura Y; Shigeta A; Kawata N; Sakao S; Kasahara Y; Tatsumi K
[Ad] Endereço:Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
[Ti] Título:Electrocardiogram-gated 320-slice multidetector computed tomography for the measurement of pulmonary arterial distensibility in chronic thromboembolic pulmonary hypertension.
[So] Source:PLoS One;9(11):e111563, 2014.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We aimed to study whether pulmonary arterial distensibility (PAD) correlates with hemodynamic parameters in chronic thromboembolic pulmonary hypertension (CTEPH) using electrocardiogram (ECG)-gated 320-slice multidetector computed tomography (MDCT). METHODS AND FINDINGS: ECG-gated 320-slice MDCT and right heart catheterization (RHC) was performed in 53 subjects (60.6±11.4 years old; 37 females) with CTEPH. We retrospectively measured the minimum and maximum values of the cross sectional area (CSA) of the main pulmonary artery (mainPA), right pulmonary artery (rtPA), and left pulmonary artery (ltPA) during one heartbeat. PAD was calculated using the following formula: PAD = [(CSAmaximum-CSAminimum)/CSAmaximum]×100(%). The correlation between hemodynamic parameters and PAD was assessed. Mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR) were 40.8±8.7 mmHg and 8.3±3.0 wood units, respectively. PAD values were as follows: mainPA (14.0±5.0%), rtPA (12.8±5.6%), and ltPA (9.7±4.6%). Good correlations existed between mainPAD, with mPAP (r = -0.594, p<0.001) and PVR (r = -0.659, p<0.001). The correlation coefficients between rtPAD and ltPAD with pulmonary hemodynamics were all lower or equal than for mainPAD. CONCLUSIONS: PAD measured using ECG-gated 320-slice MDCT correlates with pulmonary hemodynamics in subjects with CTEPH. The mainPA is suitable for PAD measurement.
[Mh] Termos MeSH primário: Hipertensão Pulmonar/complicações
Tomografia Computadorizada Multidetectores
Artéria Pulmonar/diagnóstico por imagem
Artéria Pulmonar/fisiopatologia
Embolia Pulmonar/etiologia
Capacitância Vascular
[Mh] Termos MeSH secundário: Idoso
Doença Crônica
Feminino
Hemodinâmica
Seres Humanos
Hipertensão Pulmonar/mortalidade
Hipertensão Pulmonar/fisiopatologia
Hipertensão Pulmonar/terapia
Masculino
Meia-Idade
Oxigenoterapia
Piperazinas/uso terapêutico
Embolia Pulmonar/mortalidade
Embolia Pulmonar/fisiopatologia
Embolia Pulmonar/terapia
Purinas/uso terapêutico
Fatores de Risco
Citrato de Sildenafila
Sulfonamidas/uso terapêutico
Resultado do Tratamento
Vasodilatadores/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Piperazines); 0 (Purines); 0 (Sulfonamides); 0 (Vasodilator Agents); BW9B0ZE037 (Sildenafil Citrate)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141104
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0111563


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[PMID]:25100601
[Au] Autor:Pinheiro PS; Jansen AM; de Wit H; Tawfik B; Madsen KL; Verhage M; Gether U; Sørensen JB
[Ad] Endereço:Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences and Lundbeck Foundation Center for Biomembranes in Nanomedicine, University of Copenhagen, 2200N Copenhagen, Denmark, and.
[Ti] Título:The BAR domain protein PICK1 controls vesicle number and size in adrenal chromaffin cells.
[So] Source:J Neurosci;34(32):10688-700, 2014 Aug 06.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Protein Interacting with C Kinase 1 (PICK1) is a Bin/Amphiphysin/Rvs (BAR) domain protein involved in AMPA receptor trafficking. Here, we identify a selective role for PICK1 in the biogenesis of large, dense core vesicles (LDCVs) in mouse chromaffin cells. PICK1 colocalized with syntaxin-6, a marker for immature granules. In chromaffin cells isolated from a PICK1 knockout (KO) mouse the amount of exocytosis was reduced, while release kinetics and Ca(2+) sensitivity were unaffected. Vesicle-fusion events had a reduced frequency and released lower amounts of transmitter per vesicle (i.e., reduced quantal size). This was paralleled by a reduction in the mean single-vesicle capacitance, estimated by averaging time-locked capacitance traces. EM confirmed that LDCVs were fewer and of markedly reduced size in the PICK1 KO, demonstrating that all phenotypes can be explained by reductions in vesicle number and size, whereas the fusion competence of generated vesicles was unaffected by the absence of PICK1. Viral rescue experiments demonstrated that long-term re-expression of PICK1 is necessary to restore normal vesicular content and secretion, while short-term overexpression is ineffective, consistent with an upstream role for PICK1. Disrupting lipid binding of the BAR domain (2K-E mutation) or of the PDZ domain (CC-GG mutation) was sufficient to reproduce the secretion phenotype of the null mutant. The same mutations are known to eliminate PICK1 function in receptor trafficking, indicating that the multiple functions of PICK1 involve a conserved mechanism. Summarized, our findings demonstrate that PICK1 functions in vesicle biogenesis and is necessary to maintain normal vesicle numbers and size.
[Mh] Termos MeSH primário: Glândulas Suprarrenais/citologia
Proteínas de Transporte/metabolismo
Células Cromafins/citologia
Exocitose/fisiologia
Proteínas Nucleares/metabolismo
Vesículas Secretórias/metabolismo
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Cálcio/metabolismo
Proteínas de Transporte/genética
Catecolaminas/metabolismo
Células Cultivadas
Células Cromafins/ultraestrutura
Exocitose/genética
Proteínas de Fluorescência Verde/genética
Proteínas de Fluorescência Verde/metabolismo
Potenciais da Membrana/efeitos dos fármacos
Potenciais da Membrana/genética
Camundongos
Camundongos Transgênicos
Microscopia Eletrônica de Transmissão
Proteínas Nucleares/genética
Transporte Proteico/fisiologia
Vesículas Secretórias/genética
Vesículas Secretórias/ultraestrutura
Capacitância Vascular/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (Catecholamines); 0 (Nuclear Proteins); 0 (Prkcabp protein, mouse); 0 (enhanced green fluorescent protein); 147336-22-9 (Green Fluorescent Proteins); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:161025
[Lr] Data última revisão:
161025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140808
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.5132-13.2014



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