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[PMID]:28467322
[Au] Autor:Phan PA; Hahn CEW; Farmery AD
[Ad] Endereço:Nuffield Division of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom.
[Ti] Título:A modification of the Bohr method to determine airways deadspace for non-uniform inspired gas tensions.
[So] Source:Physiol Meas;38(7):N107-N117, 2017 Jun 22.
[Is] ISSN:1361-6579
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The Bohr method is a technique to determine airways deadspace using a tracer gas such as carbon dioxide or nitrogen. It is based on the assumption that the inspired concentration of the tracer gas is constant throughout inspiration. However, in some lung function measurement techniques where inspired concentration of the tracer gas may be required to vary, or where rapid injection of the tracer gas is made in real time, uniform inspired concentration is difficult or impossible to achieve, which leads to inaccurate estimation of deadspace using the Bohr equation. One such lung function measurement technique is the inspired sinewave technique. OBJECTIVE: In this paper, we proposed a modification of the Bohr method, relaxing the requirement of absolute uniformity of tracer concentration in the inspired breath. METHOD: The new method used integration of flow and concentration. A computer algorithm sought an appropriate value of deadspace to satisfy the mass balance equation for each breath. A modern gas mixing apparatus with rapid mass flow controllers was used to verify the procedure. RESULT: Experiments on a tidally ventilated bench lung showed that the new method estimated dead space within 10% of the actual values whereas the traditional Bohr deadspace gave more than 50% error. CONCLUSION: The new method improved the accuracy of deadspace estimation when the inspired concentration is not uniform. This improvement would lead to more accurate diagnosis and more accurate estimations of other lung parameters such as functional residual capacity and pulmonary blood flow.
[Mh] Termos MeSH primário: Testes de Função Respiratória/métodos
Fenômenos Fisiológicos Respiratórios
[Mh] Termos MeSH secundário: Dióxido de Carbono/metabolismo
Seres Humanos
Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
142M471B3J (Carbon Dioxide); S88TT14065 (Oxygen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1088/1361-6579/aa70c0


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[PMID]:29185590
[Au] Autor:Biagini S; Dale CS; Real JM; Moreira ES; Carvalho CRR; Schettino GPP; Wendel S; Azevedo LCP
[Ad] Endereço:Instituto de Ensino e Pesquisa, Hospital Sírio-Libanês, São Paulo, SP, Brasil.
[Ti] Título:Short-term effects of stored homologous red blood cell transfusion on cardiorespiratory function and inflammation: an experimental study in a hypovolemia model.
[So] Source:Braz J Med Biol Res;51(1):e6258, 2017 Nov 17.
[Is] ISSN:1414-431X
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The pathophysiological mechanisms associated with the effects of red blood cell (RBC) transfusion on cardiopulmonary function and inflammation are unclear. We developed an experimental model of homologous 14-days stored RBC transfusion in hypovolemic swine to evaluate the short-term effects of transfusion on cardiopulmonary system and inflammation. Sixteen healthy male anesthetized swine (68±3.3 kg) were submitted to controlled hemorrhage (25% of blood volume). Two units of non-filtered RBC from each animal were stored under blood bank conditions for 14 days. After 30 min of hypovolemia, the control group (n=8) received an infusion of lactated Ringer's solution (three times the removed volume). The transfusion group (n=8) received two units of homologous 14-days stored RBC and lactated Ringer's solution in a volume that was three times the difference between blood removed and blood transfusion infused. Both groups were followed up for 6 h after resuscitation with collection of hemodynamic and respiratory data. Cytokines and RNA expression were measured in plasma and lung tissue. Stored RBC transfusion significantly increased mixed oxygen venous saturation and arterial oxygen content. Transfusion was not associated with alterations on pulmonary function. Pulmonary concentrations of cytokines were not different between groups. Gene expression for lung cytokines demonstrated a 2-fold increase in mRNA level for inducible nitric oxide synthase and a 0.5-fold decrease in mRNA content for IL-21 in the transfused group. Thus, stored homologous RBC transfusion in a hypovolemia model improved cardiovascular parameters but did not induce significant effects on microcirculation, pulmonary inflammation and respiratory function up to 6 h after transfusion.
[Mh] Termos MeSH primário: Preservação de Sangue/métodos
Fenômenos Fisiológicos Cardiovasculares
Transfusão de Eritrócitos/métodos
Hipovolemia/terapia
Pneumonia/fisiopatologia
Fenômenos Fisiológicos Respiratórios
[Mh] Termos MeSH secundário: Animais
Preservação de Sangue/efeitos adversos
Citocinas/sangue
Modelos Animais de Doenças
Ensaio de Imunoadsorção Enzimática
Transfusão de Eritrócitos/efeitos adversos
Hemodinâmica
Masculino
Oxigênio/metabolismo
Reprodutibilidade dos Testes
Ressuscitação/métodos
Suínos
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); S88TT14065 (Oxygen)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE


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[PMID]:28459320
[Au] Autor:Calverley PMA
[Ad] Endereço:1 Institute of Ageing and Chronic Disease University of Liverpool Liverpool, United Kingdom.
[Ti] Título:AJRCCM: 100-Year Anniversary. Physiology and Chronic Obstructive Pulmonary Disease in the Blue Journals.
[So] Source:Am J Respir Crit Care Med;195(9):1088-1090, 2017 May 01.
[Is] ISSN:1535-4970
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Publicações Periódicas como Assunto/história
Doença Pulmonar Obstrutiva Crônica/fisiopatologia
Pneumologia/história
Fenômenos Fisiológicos Respiratórios
[Mh] Termos MeSH secundário: Aniversários e Eventos Especiais
Volume Expiratório Forçado
História do Século XX
História do Século XXI
Seres Humanos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1164/rccm.201701-0114ED


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[PMID]:28459329
[Au] Autor:Berry CE; Drummond MB
[Ad] Endereço:1 Department of Medicine University of Arizona College of Medicine Tucson, Arizona and.
[Ti] Título:The Horse-Racing Effect and Lung Function: Can We Slow the Fastest Horse?
[So] Source:Am J Respir Crit Care Med;195(9):1134-1135, 2017 05 01.
[Is] ISSN:1535-4970
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Fenômenos Fisiológicos Respiratórios
Esportes
[Mh] Termos MeSH secundário: Animais
Cavalos
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1164/rccm.201703-0540ED


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[PMID]:29088265
[Au] Autor:Pazhoohan S; Raoufy MR; Javan M; Hajizadeh S
[Ad] Endereço:Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
[Ti] Título:Effect of Rho-kinase inhibition on complexity of breathing pattern in a guinea pig model of asthma.
[So] Source:PLoS One;12(10):e0187249, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Asthma represents an episodic and fluctuating behavior characterized with decreased complexity of respiratory dynamics. Several evidence indicate that asthma severity or control is associated with alteration in variability of lung function. The pathophysiological basis of alteration in complexity of breathing pattern in asthma has remained poorly understood. Regarding the point that Rho-kinase is involved in pathophysiology of asthma, in present study we investigated the effect of Rho-kinase inhibition on complexity of respiratory dynamics in a guinea pig model of asthma. Male Dunkin Hartley guinea pigs were exposed to 12 series of inhalations with ovalbumin or saline. Animals were treated by the Rho-kinase inhibitor Y-27632 (1mM aerosols) prior to each allergen challenge. We recorded respiration of conscious animals using whole-body plethysmography. Exposure to ovalbumin induced lung inflammation, airway hyperresponsiveness and remodeling including goblet cell hyperplasia, increase in the thickness of airways smooth muscles and subepithelial collagen deposition. Complexity analysis of respiratory dynamics revealed a dramatic decrease in irregularity of respiratory rhythm representing less complexity in asthmatic guinea pigs. Inhibition of Rho-kinase reduced the airway remodeling and hyperreponsiveness, but had no significant effect on lung inflammation and complexity of respiratory dynamics in asthmatic animals. It seems that airway hyperresponsiveness and remodeling do not significantly affect the complexity of respiratory dynamics. Our results suggest that inflammation might be the probable cause of shift in the respiratory dynamics away from the normal fluctuation in asthma.
[Mh] Termos MeSH primário: Asma/fisiopatologia
Respiração/efeitos dos fármacos
Quinases Associadas a rho/antagonistas & inibidores
[Mh] Termos MeSH secundário: Amidas/farmacologia
Animais
Asma/tratamento farmacológico
Modelos Animais de Doenças
Cobaias
Masculino
Pletismografia Total
Piridinas/farmacologia
Fenômenos Fisiológicos Respiratórios/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amides); 0 (Pyridines); 138381-45-0 (Y 27632); EC 2.7.11.1 (rho-Associated Kinases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171101
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0187249


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[PMID]:28886594
[Au] Autor:Raanan R; Gunier RB; Balmes JR; Beltran AJ; Harley KG; Bradman A; Eskenazi B
[Ad] Endereço:Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley , Berkeley, California, USA.
[Ti] Título:Elemental Sulfur Use and Associations with Pediatric Lung Function and Respiratory Symptoms in an Agricultural Community (California, USA).
[So] Source:Environ Health Perspect;125(8):087007, 2017 08 10.
[Is] ISSN:1552-9924
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Elemental sulfur, "the oldest of all pesticides," is the most heavily used agricultural pesticide in California and Europe. Sulfur is considered relatively safe and is used in both conventional and organic farming systems. Adverse respiratory effects have been reported in applicators and animals, but the effect on residential populations, and especially on children living in proximity to fields treated with elemental sulfur, is not known. OBJECTIVES: We evaluated associations between residential proximity to elemental sulfur applications and respiratory symptoms and spirometry of children living in an agricultural community. METHODS: Participants were enrolled in the CHAMACOS longitudinal birth cohort. We collected respiratory symptomatology for 347 children at 7 y of age and measured spirometry on a subset of 279. Of these, estimations of proximity to sulfur application and relevant covariate data were available for 237 and 205 children for whom we had symptomatology information and FEV measurements, respectively. Data from the California Pesticide Use Reporting System were used to estimate the amount of elemental sulfur applied within 0.5, 1, and 3km of a child's residence during the week, month, and 12 mo prior to pulmonary evaluation. Regression models controlled for maternal smoking during pregnancy; season of birth; PM (particulate matter ≤2.5mm in aerodynamic diameter); breast feeding duration; child's sex, age, and height; technician; and other covariates. RESULTS: Adverse associations with respiratory outcomes were found for sulfur applications within 0.5- and 1-km radii. Specifically, asthma medication usage and respiratory symptoms increased [OR=3.51; 95% confidence interval (CI): 1.50, 8.23, =0.004; OR=2.09; 95% CI: 1.27, 3.46, =0.004, respectively] and FEV decreased (ß=−0.143; 95% CI: −0.248, −0.039, =0.008) per 10-fold increase in the estimated amount of sulfur used within 1 km of child residence during the year prior to pulmonary evaluation. CONCLUSIONS: This study suggests that elemental sulfur use, allowed in both organic and conventional farming, in close proximity to residential areas, may adversely affect children's respiratory health. https://doi.org/10.1289/EHP528.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/análise
Poluição do Ar/estatística & dados numéricos
Exposição por Inalação/estatística & dados numéricos
Praguicidas/análise
Doenças Respiratórias/epidemiologia
Enxofre/análise
[Mh] Termos MeSH secundário: Agricultura/métodos
Agricultura/estatística & dados numéricos
California/epidemiologia
Criança
Feminino
Seres Humanos
Masculino
Distribuição Espacial da População
Fenômenos Fisiológicos Respiratórios
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Pesticides); 70FD1KFU70 (Sulfur)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1289/EHP528


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[PMID]:28821389
[Au] Autor:Wingen A; Carrera P; Ekaterini Psathaki O; Voelzmann A; Paululat A; Hoch M
[Ad] Endereço:Developmental Genetic&Molecular Physiology Unit, Life&Medical Sciences Institute (LIMES), University of Bonn, Carl-Troll-Strasse 31, D-53115 Bonn, Germany.
[Ti] Título:Debris buster is a Drosophila scavenger receptor essential for airway physiology.
[So] Source:Dev Biol;430(1):52-68, 2017 10 01.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Scavenger receptors class B (SR-B) are multifunctional transmembrane proteins, which in vertebrates participate in lipid transport, pathogen clearance, lysosomal delivery and intracellular sorting. Drosophila has 14 SR-B members whose functions are still largely unknown. Here, we reveal a novel role for the SR-B family member Debris buster (Dsb) in Drosophila airway physiology. Larvae lacking dsb show yeast avoidance behavior, hypoxia, and severe growth defects associated with impaired elongation and integrity along the airways. Furthermore, in dsb mutant embryos, the barrier function of the posterior spiracles, which are critical for gas exchange, is not properly established and liquid clearance is locally impaired at the spiracular lumen. We found that Dsb is specifically expressed in a group of distal epithelial cells of the posterior spiracle organ and not throughout the entire airways. Furthermore, tissue-specific knockdown and rescue experiments demonstrate that Dsb function in the airways is only required in the posterior spiracles. Dsb localizes in intracellular vesicles, and a subset of these associate with lysosomes. However, we found that depletion of proteins involved in vesicular transport to the apical membrane, but not in lysosomal function, causes dsb-like airway elongation defects. We propose a model in which Dsb sorts components of the apical extracellular matrix which are essential for airway physiology. Since SR-B LIMP2-deficient mice show reduced expression of several apical plasma membrane proteins, sorting of proteins to the apical membrane is likely an evolutionary conserved function of Dsb and LIMP2. Our data provide insights into a spatially confined function of the SR-B Dsb in intracellular trafficking critical for the physiology of the whole tubular airway network.
[Mh] Termos MeSH primário: Proteínas de Drosophila/metabolismo
Drosophila melanogaster/metabolismo
Receptores Depuradores/metabolismo
Fenômenos Fisiológicos Respiratórios
Sistema Respiratório/metabolismo
[Mh] Termos MeSH secundário: Animais
Proteínas de Drosophila/genética
Drosophila melanogaster/citologia
Drosophila melanogaster/embriologia
Embrião não Mamífero/metabolismo
Matriz Extracelular/metabolismo
Regulação da Expressão Gênica
Hipóxia/metabolismo
Espaço Intracelular/metabolismo
Larva/metabolismo
Mutação/genética
Transporte Proteico
Interferência de RNA
Receptores Depuradores/genética
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drosophila Proteins); 0 (Dsb protein, Drosophila); 0 (Receptors, Scavenger); 059QF0KO0R (Water)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170820
[St] Status:MEDLINE


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[PMID]:28768555
[Au] Autor:Price A; Eccles R
[Ad] Endereço:Common Cold Centre,Cardiff School of Biosciences,Cardiff University,Wales,UK.
[Ti] Título:Is there any relationship between right and left hand dominance and right and left nasal airflow dominance?
[So] Source:J Laryngol Otol;131(10):846-852, 2017 Oct.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Left- or right-handedness is a common human trait, and it has been previously reported that human nasal airflow dominance correlates with hand dominance. Any relationship between hand dominance and nasal airflow dominance would be unusual. This study aimed to measure nasal airflow and look for any relationship to handedness. METHODS: The modified Glatzel mirror was used to record the dominant nasal passage at 15-minute intervals over a 6-hour period in 29 healthy participants consisting of 15 left-handers and 14 right-handers. RESULTS: In left-handers, the percentage of time that the left nasal passage was dominant ranged from 0 to 100 per cent. In right-handers, the percentage of time that the right nasal passage was dominant ranged from 4.2 to 95.8 per cent. No correlation between nasal airflow dominance and hand dominance was identified. CONCLUSION: The results do not support the hypothesis that nasal airflow and handedness are related.
[Mh] Termos MeSH primário: Lateralidade Funcional
Mãos/fisiologia
Cavidade Nasal/fisiologia
[Mh] Termos MeSH secundário: Adulto
Dominância Cerebral
Feminino
Seres Humanos
Masculino
Projetos Piloto
Estudos Prospectivos
Fenômenos Fisiológicos Respiratórios
Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1017/S0022215117001475


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[PMID]:28631764
[Au] Autor:Marini M; Caretta G; Vagnarelli F; Lucà F; Biscottini E; Lavorgna A; Procaccini V; Riva L; Vianello G; Aspromonte N; Mortara A; De Maria R; Capasso P; Valente S; Gulizia MM
[Ad] Endereço:S.O.D. Cardiologia-Emodinamica-UTIC, Dipartimento di Scienze Cardiovascolari, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Ancona - Area Giovani ANMCO.
[Ti] Título:[Hemodynamic effects of positive end-expiratory pressure].
[Ti] Título:Gli effetti emodinamici della pressione positiva di fine espirazione..
[So] Source:G Ital Cardiol (Rome);18(6):505-512, 2017 Jun.
[Is] ISSN:1827-6806
[Cp] País de publicação:Italy
[La] Idioma:ita
[Ab] Resumo:The application of a positive end-expiratory pressure (PEEP), the cornerstone of noninvasive ventilation (NIV), causes hemodynamic changes in the cardiovascular system. To understand the benefits of NIV it is necessary to resume concepts of cardiovascular physiology and pathophysiology about cardiac function determinants, venous return, ventricular interdependence and heart-lung interaction, and to understand how PEEP interacts with them. The hemodynamic effects of PEEP are mediated by the increase in transpulmonary pressure, which results in increased pulmonary vascular resistance and in an attending small reduction of venous return in conditions of euvolemia, in a substantial reduction of left ventricular afterload and a potential positive effect on left ventricular stroke volume.The aim of this review is to describe how the application of PEEP does not necessarily induce detrimental hemodynamic effects, but may decrease oxygen consumption and improve cardiac performance. These effects can justify the use of NIV in hemodynamically unstable patients.
[Mh] Termos MeSH primário: Hemodinâmica
Respiração com Pressão Positiva
[Mh] Termos MeSH secundário: Coração/fisiologia
Seres Humanos
Oxigênio/sangue
Consumo de Oxigênio
Pressão Parcial
Fenômenos Fisiológicos Respiratórios
Resistência Vascular
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
S88TT14065 (Oxygen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1714/2700.27611


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[PMID]:28482384
[Au] Autor:Chen WM; Yan GF; Lu ZJ; Lu GP
[Ad] Endereço:Department of Pediatric Emergency Medicine, Children's Hospital of Fudan University, Shanghai 201102, China.
[Ti] Título:[Effects and mechanisms of high-volume hemofiltration on endotoxin-induced acute lung injury of piglets].
[So] Source:Zhonghua Er Ke Za Zhi;55(5):343-348, 2017 May 04.
[Is] ISSN:0578-1310
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To compare the effects of high-volume hemofiltration (HVHF) and continuous veno-venous hemofiltration (CVVH) on cardiopulmonary functions, lung fluid balance, lung damage and cytokine expression in endotoxin-induced acute lung injury piglet model, and to further evaluate the value of high-volume hemofiltration in acute lung injury. Eighteen piglets were randomly divided into the control group (6 piglets), the CVVH group (6 piglets) and the HVHF group (6 piglets). By general anesthesia, the intravenous infusion of 0.15 mg/kg endotoxin were received in all the animals and induced acute lung injury.High-volume hemofiltration and continuous veno-venous hemofiltration were addressed to different groups.Subsequently, hemodynamic parameters (heart rate, mean arterial blood pressure, central venous pressure, pulse contour cardiac index, systemic venous resistance index and extravascular lung water index) as well as gas exchange and lung mechanics parameters (respiratory rate, partial pressure of carbon dioxide, partial pressure of oxygen/fraction of inspired oxygen, dynamic lung compliance and airway resistance) were intermittently measured.Lung tissues were collected for further analysis (the lung wet-to-dry weight ratio, lung injury scoring). The plasma protein levels of cytokines (interleukin(IL) -6, 10 and tumor necrosis factors alpha(TNF-α)) were also assessed. - ( ) and - were conducted to identify significant differences among the control, CVVH and HVHF group. Compared with CVVH, HVHF had the capacity to improve significantly the index of Cdyn(HVHF (2.3±0.5) . CVVH (1.5±0.5) ml/(cmH(2)O·kg), 1 cmH(2)O=0.098 kPa, <0.05)and Rrs(HVHF (22.0±1.9) .CVVH (29.5±1.5) cmH(2)O/(L·s), <0.05)at the time of 6 h, and decreased lung water accumulation(index of EVLWI in HVHF (22.7±2.1) .CVVH (39.5±2.6) ml/m(2,) <0.01) at the time of 6 h, and the plasma concentration of cytokines(IL-6, IL-10, TNF-α)in the HVHF group had an obvious decline compared with those in the CVVH group at the time of 6 h( (200±55) . (280±61), (74±17) . (102±21), (54±13) . (73±21) pg/ml, all <0.05). The lung injury scoring of HVHF group was significantly lower than those of CVVH group((7.8±1.9) . (11.3±2.2) scores, <0.05). Although the plasma concentration of cytokines(IL-6, IL-10, TNF-α) in the CVVH group were lower than those in the control group at the time of 6 h((374±55), (137±25), (98±17) pg/ml, all <0.05), the indexes of respiratory function were not improved (all <0.05). Different doses hemofiltration can reduce plasma inflammatory mediators indicators in piglets.Early high volume hemofiltration can improve respiratory function of piglets with endotoxin-induced acute lung injury and reduce lung injury pathological score.
[Mh] Termos MeSH primário: Lesão Pulmonar Aguda
Hemofiltração
Fenômenos Fisiológicos Respiratórios
[Mh] Termos MeSH secundário: Animais
Pressão Arterial
Pressão Venosa Central
Citocinas
Endotoxinas
Água Extravascular Pulmonar
Frequência Cardíaca
Hemodinâmica
Interleucina-10
Interleucina-6
Pulmão
Lesão Pulmonar/prevenção & controle
Masculino
Oxigênio
Suínos
Fator de Necrose Tumoral alfa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Endotoxins); 0 (Interleukin-6); 0 (Tumor Necrosis Factor-alpha); 130068-27-8 (Interleukin-10); S88TT14065 (Oxygen)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0578-1310.2017.05.007



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