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Pesquisa : G09.772.705 [Categoria DeCS]
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[PMID]:27776225
[Au] Autor:Matt F; Cole-Hunter T; Donaire-Gonzalez D; Kubesch N; Martínez D; Carrasco-Turigas G; Nieuwenhuijsen M
[Ad] Endereço:ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Rudolf Boehm Institute of Pharmacology and Toxicology, PGS Toxicology and Environmental Protection, University of Leipzig, Leipzig, Germany; Biological Safety & Risk Management, Institute Straumann AG, Basel,
[Ti] Título:Acute respiratory response to traffic-related air pollution during physical activity performance.
[So] Source:Environ Int;97:45-55, 2016 12.
[Is] ISSN:1873-6750
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Physical activity (PA) has beneficial, whereas exposure to traffic related air pollution (TRAP) has adverse, respiratory effects. Few studies, however, have examined if the acute effects of TRAP upon respiratory outcomes are modified depending on the level of PA. OBJECTIVES: The aim of our study was to disentangle acute effects of TRAP and PA upon respiratory outcomes and assess the impact of participants TRAP pre-exposure. METHODS: We conducted a real-world crossover study with repeated measures of 30 healthy adults. Participants completed four 2-h exposure scenarios that included either rest or intermittent exercise in high- and low-traffic environments. Measures of respiratory function were collected at three time points. Pre-exposure to TRAP was ascertained from land-use-modeled address-attributed values. Mixed-effects models were used to estimate the impact of TRAP and PA on respiratory measures as well as potential effect modifications. RESULTS: We found that PA was associated with a statistically significant increases of FEV (48.5mL, p=0.02), FEV /FVC (0.64%, p=0.005) and FEF (97.8mL, p=0.02). An increase in exposure to one unit (1µg/m ) of PM was associated with a decrease in FEV (-1.31mL, p=0.02) and FVC (-1.71mL, p=0.01), respectively. On the other hand, for an otherwise equivalent exposure an increase of PA by one unit (1%Heart rate max) was found to reduce the immediate negative effects of particulate matter (PM) upon PEF (PM , 0.02L/min, p=0.047; PM , 0.02L/min p=0.02; PM , 0.03L/min, p=0.02) and the several hours delayed negative effects of PM upon FVC (PM , 0.11mL, p=0.02). The negative impact of exposure to TRAP constituents on FEV /FVC and PEF was attenuated in those participants with higher TRAP pre-exposure levels. CONCLUSIONS: Our results suggest that associations between various pollutant exposures and respiratory measures are modified by the level of PA during exposure and TRAP pre-exposure of participants.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/toxicidade
Poluição do Ar/efeitos adversos
Exercício
Material Particulado/toxicidade
Respiração/efeitos dos fármacos
Emissões de Veículos/toxicidade
[Mh] Termos MeSH secundário: Adulto
Poluentes Atmosféricos/análise
Poluição do Ar/análise
Estudos Cross-Over
Feminino
Frequência Cardíaca/efeitos dos fármacos
Seres Humanos
Masculino
Meia-Idade
Modelos Teóricos
Veículos Automotores
Material Particulado/análise
Testes de Função Respiratória
Emissões de Veículos/análise
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Particulate Matter); 0 (Vehicle Emissions)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180311
[Lr] Data última revisão:
180311
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29237524
[Au] Autor:Li L; Chen Q; Zhang F; Zhu SG; Hu CL; Wu AM
[Ad] Endereço:Department of Respiration, Jiangxi Children's Hospital, Nanchang 330000, China. nclilan@163.com.
[Ti] Título:[Characteristics of tidal breathing pulmonary function in children with tracheobronchomalacia].
[So] Source:Zhongguo Dang Dai Er Ke Za Zhi;19(12):1248-1251, 2017 Dec.
[Is] ISSN:1008-8830
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate the characteristics of tidal breathing pulmonary function in children with tracheobronchomalacia (TBM). METHODS: In this study, 30 children who were diagnosed with TBM using electronic bronchoscopy were enrolled in the observation group; 30 healthy children were recruited in the normal control group. For individuals in each group, the assessment of tidal breath pulmonary function was performed at diagnosis and 3, 6, 9, and 12 months after diagnosis. RESULTS: There were no significant differences in tidal volume, inspiratory time, expiratory time, and inspiratory to expiratory ratio between the two groups (P>0.05). Compared with the control group, the observation group had a significantly higher respiratory rate and significantly lower ratio of time to peak tidal expiratory flow to total expiratory time (TPTEF/TE) and ratio of volume to peak tidal expiratory flow to total expiratory volume (VPTEF/VE). There was a time-dependent increase in TPTEF/TE and VPTEF/VE for TBM children from the time of initial diagnosis to 12 months after diagnosis. CONCLUSIONS: Tidal breathing pulmonary function has characteristic changes in children with TBM. Tidal breathing pulmonary function tends to be recovered with increased age in children with TBM.
[Mh] Termos MeSH primário: Pulmão/fisiopatologia
Respiração
Volume de Ventilação Pulmonar
Traqueobroncomalácia/fisiopatologia
[Mh] Termos MeSH secundário: Fatores Etários
Feminino
Seres Humanos
Lactente
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


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[PMID]:28470921
[Au] Autor:Swol J; Strauch JT; Schildhauer TA
[Ad] Endereço:Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Würzburg, Germany.
[Ti] Título:Tracheostomy as a bridge to spontaneous breathing and awake-ECMO in non-transplant surgical patients.
[So] Source:Eur J Heart Fail;19 Suppl 2:120-123, 2017 May.
[Is] ISSN:1879-0844
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: The tracheostomy is a frequently used procedure for the respiratory weaning of ventilated patients allows sedation free ECLS use in awake patient. The aim of this study is to assess the possibility and highlight the benefits of lowering the impact of sedation in surgical non-transplant patients on ECLS. The specific objective was to investigate the use of tracheostomy as a bridge to spontaneous breathing on ECLS. METHODS AND RESULTS: Of the 95 patients, 65 patients received a tracheostomy, and 5 patients were admitted with a tracheostoma. One patient was cannulated without intubation, one is extubated during ECLS course after 48 hours. 4 patients were extubated after weaning and the removal of ECLS. 19 patients died before the indication to tracheostomy was given. CONCLUSION: Tracheostomy can bridge to spontaneous breathing and awake-ECMO in non-transplant surgical patients. The "awake ECMO" strategy may avoid complications related to mechanical ventilation, sedation, and immobilization and provide comparable outcomes to other approaches for providing respiratory support.
[Mh] Termos MeSH primário: Oxigenação por Membrana Extracorpórea
Respiração Artificial/métodos
Respiração
Insuficiência Respiratória/terapia
Traqueostomia/métodos
Desmame do Respirador/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1002/ejhf.856


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[PMID]:28749375
[Au] Autor:Kontaxis C; Bol GH; Stemkens B; Glitzner M; Prins FM; Kerkmeijer LGW; Lagendijk JJW; Raaymakers BW
[Ad] Endereço:Department of Radiotherapy, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands.
[Ti] Título:Towards fast online intrafraction replanning for free-breathing stereotactic body radiation therapy with the MR-linac.
[So] Source:Phys Med Biol;62(18):7233-7248, 2017 Aug 21.
[Is] ISSN:1361-6560
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The hybrid MRI-radiotherapy machines, like the MR-linac (Elekta AB, Stockholm, Sweden) installed at the UMC Utrecht (Utrecht, The Netherlands), will be able to provide real-time patient imaging during treatment. In order to take advantage of the system's capabilities and enable online adaptive treatments, a new generation of software should be developed, ranging from motion estimation to treatment plan adaptation. In this work we present a proof of principle adaptive pipeline designed for high precision stereotactic body radiation therapy (SBRT) suitable for sites affected by respiratory motion, like renal cell carcinoma (RCC). We utilized our research MRL treatment planning system (MRLTP) to simulate a single fraction 25 Gy free-breathing SBRT treatment for RCC by performing inter-beam replanning for two patients and one volunteer. The simulated pipeline included a combination of (pre-beam) 4D-MRI and (online) 2D cine-MR acquisitions. The 4DMRI was used to generate the mid-position reference volume, while the cine-MRI, via an in-house motion model, provided three-dimensional (3D) deformable vector fields (DVFs) describing the anatomical changes during treatment. During the treatment fraction, at an inter-beam interval, the mid-position volume of the patient was updated and the delivered dose was accurately reconstructed on the underlying motion calculated by the model. Fast online replanning, targeting the latest anatomy and incorporating the previously delivered dose was then simulated with MRLTP. The adaptive treatment was compared to a conventional mid-position SBRT plan with a 3 mm planning target volume margin reconstructed on the same motion trace. We demonstrate that our system produced tighter dose distributions and thus spared the healthy tissue, while delivering more dose to the target. The pipeline was able to account for baseline variations/drifts that occurred during treatment ensuring target coverage at the end of the treatment fraction.
[Mh] Termos MeSH primário: Fracionamento de Dose
Imagem por Ressonância Magnética
Aceleradores de Partículas
Radiocirurgia/instrumentação
Planejamento da Radioterapia Assistida por Computador/métodos
Radioterapia Guiada por Imagem/instrumentação
[Mh] Termos MeSH secundário: Seres Humanos
Movimento
Respiração
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1088/1361-6560/aa82ae


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[PMID]:29390317
[Au] Autor:Zhang A; Li J; Qiu H; Wang W; Guo Y
[Ad] Endereço:School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences.
[Ti] Título:Comparison of rigid and deformable registration through the respiratory phases of four-dimensional computed tomography image data sets for radiotherapy after breast-conserving surgery.
[So] Source:Medicine (Baltimore);96(50):e9143, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of this study was to compare the geometric differences in gross tumor volume (GTV) and surgical clips propagated by rigid image registration (RIR) and deformable image registration (DIR) using a four-dimensional computed tomography (4DCT) image data set for patients treated with boost irradiation or accelerated partial breast irradiation after breast-conserving surgery (BCS). METHODS: The 4DCT data sets of 44 patients who had undergone BCS were acquired. GTV and selected clips were manually delineated on end-inhalation phase (CT0) and end-exhalation phase (CT50) images of 4DCT data sets. Subsequently, the GTV and selected clips from CT0 images were transformed and propagated to CT50 images using RIR and DIR, respectively. The geometric differences in GTV and surgical clips from DIR were compared with those of RIR. RESULTS: The mean Dice similarity coefficient (DSC) index was 0.860 ±â€Š0.042 for RIR and 0.870 ±â€Š0.040 for DIR for GTV (P = .000). The three-dimensional distance to the center of mass (COM) of the GTV from RIR was longer than that from DIR (1.22 mm and 1.10 mm, respectively, P = .000). Moreover, in the anterior-posterior direction, displacements from RIR were significantly greater than those from DIR for both GTV (0.70 mm and 0.50 mm, respectively) and selected clips (upper clip, 0.45 mm vs 0.20 mm; inner clip, 0.55 mm vs 0.30 mm; outer clip, 0.40 mm vs 0.20 mm; lower clip, 0.50 mm vs 0.25 mm) (P = .000). However, in the left-right and superior-inferior directions, there were no significant displacement differences between RIR and DIR for GTV and the selected clips (all P > .050). CONCLUSION: DIR can improve the overlap for GTV registration from CT0 to CT50 images from 4DCT scanning. Furthermore, DIR is superior to RIR in reflecting the displacement of GTV and selected clips in the anterior-posterior direction induced by respiratory movement.
[Mh] Termos MeSH primário: Neoplasias da Mama/diagnóstico por imagem
Neoplasias da Mama/cirurgia
Tomografia Computadorizada Quadridimensional
Mastectomia Segmentar
Planejamento da Radioterapia Assistida por Computador
[Mh] Termos MeSH secundário: Adulto
Neoplasias da Mama/patologia
Feminino
Seres Humanos
Meia-Idade
Respiração
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009143


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[PMID]:28463165
[Au] Autor:Li G; Wei J; Kadbi M; Moody J; Sun A; Zhang S; Markova S; Zakian K; Hunt M; Deasy JO
[Ad] Endereço:Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address: lig2@mskcc.org.
[Ti] Título:Novel Super-Resolution Approach to Time-Resolved Volumetric 4-Dimensional Magnetic Resonance Imaging With High Spatiotemporal Resolution for Multi-Breathing Cycle Motion Assessment.
[So] Source:Int J Radiat Oncol Biol Phys;98(2):454-462, 2017 06 01.
[Is] ISSN:1879-355X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To develop and evaluate a super-resolution approach to reconstruct time-resolved 4-dimensional magnetic resonance imaging (TR-4DMRI) with a high spatiotemporal resolution for multi-breathing cycle motion assessment. METHODS AND MATERIALS: A super-resolution approach was developed to combine fast 3-dimensional (3D) cine MRI with low resolution during free breathing (FB) and high-resolution 3D static MRI during breath hold (BH) using deformable image registration. A T1-weighted, turbo field echo sequence, coronal 3D cine acquisition, partial Fourier approximation, and SENSitivity Encoding parallel acceleration were used. The same MRI pulse sequence, field of view, and acceleration techniques were applied in both FB and BH acquisitions; the intensity-based Demons deformable image registration method was used. Under an institutional review board-approved protocol, 7 volunteers were studied with 3D cine FB scan (voxel size: 5 × 5 × 5 mm ) at 2 Hz for 40 seconds and a 3D static BH scan (2 × 2 × 2 mm ). To examine the image fidelity of 3D cine and super-resolution TR-4DMRI, a mobile gel phantom with multi-internal targets was scanned at 3 speeds and compared with the 3D static image. Image similarity among 3D cine, 4DMRI, and 3D static was evaluated visually using difference image and quantitatively using voxel intensity correlation and Dice index (phantom only). Multi-breathing-cycle waveforms were extracted and compared in both phantom and volunteer images using the 3D cine as the references. RESULTS: Mild imaging artifacts were found in the 3D cine and TR-4DMRI of the mobile gel phantom with a Dice index of >0.95. Among 7 volunteers, the super-resolution TR-4DMRI yielded high voxel-intensity correlation (0.92 ± 0.05) and low voxel-intensity difference (<0.05). The detected motion differences between TR-4DMRI and 3D cine were -0.2 ± 0.5 mm (phantom) and -0.2 ± 1.9 mm (diaphragms). CONCLUSION: Super-resolution TR-4DMRI has been reconstructed with adequate temporal (2 Hz) and spatial (2 × 2 × 2 mm ) resolutions. Further TR-4DMRI characterization and improvement are necessary before clinical applications. Multi-breathing cycles can be examined, providing patient-specific breathing irregularities and motion statistics for future 4D radiation therapy.
[Mh] Termos MeSH primário: Suspensão da Respiração
Aumento da Imagem/métodos
Imagem Tridimensional/métodos
Imagem Cinética por Ressonância Magnética/métodos
Movimento
Respiração
[Mh] Termos MeSH secundário: Artefatos
Análise de Fourier
Seres Humanos
Imagem Tridimensional/normas
Imagem Cinética por Ressonância Magnética/normas
Movimento (Física)
Imagens de Fantasmas
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:29357379
[Au] Autor:Darwiche W; Gay-Quéheillard J; Delanaud S; El Khayat El Sabbouri H; Khachfe H; Joumaa W; Bach V; Ramadan W
[Ad] Endereço:PériTox, Périnatalité & Risques Toxiques, UMR-I 01 INERIS, Amiens, France.
[Ti] Título:Impact of chronic exposure to the pesticide chlorpyrifos on respiratory parameters and sleep apnea in juvenile and adult rats.
[So] Source:PLoS One;13(1):e0191237, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The widely used organophosphorus pesticide chlorpyrifos (CPF) is often detected in food. CPF inhibits acetylcholinesterase and can modify muscle contractility and respiratory patterns. We studied the effects of chronic exposure to CPF on respiratory parameters and diaphragm contractility in 21- and 60-days old rats. Pregnant rats were exposed to oral CPF (1 or 5 mg/ kg /day: CPF-1 or CPF-5 groups vs vehicle: controls) from gestation onset up to weaning of the pups that were individually gavaged (CPF or vehicle) thereafter. Two developmental time points were studied: weaning (day 21) and adulthood (day 60). Whole-body plethysmography was used to score breathing patterns and apnea index during sleep. Then, diaphragm strips were dissected for the assessment of contractility and acetylcholinesterase activity. Results showed that the sleep apnea index was higher in CPF-exposed rats than in controls. In adult rats, the expiratory time and tidal volume were higher in CPF-exposed animals than in controls. At both ages, the diaphragm's amplitude of contraction and fatigability index were higher in the CPF-5 group, due to lower acetylcholinesterase activity. We conclude that chronic exposure to CPF is associated with higher sleep apnea index and diaphragm contractility, and modifies respiratory patterns in sleeping juvenile and adult rats.
[Mh] Termos MeSH primário: Clorpirifos/toxicidade
Praguicidas/toxicidade
Respiração/efeitos dos fármacos
Síndromes da Apneia do Sono/induzido quimicamente
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Animais
Clorpirifos/administração & dosagem
Inibidores da Colinesterase/administração & dosagem
Inibidores da Colinesterase/toxicidade
Diafragma/efeitos dos fármacos
Diafragma/fisiopatologia
Feminino
Masculino
Contração Muscular/efeitos dos fármacos
Pletismografia Total
Gravidez
Efeitos Tardios da Exposição Pré-Natal/fisiopatologia
Ratos
Síndromes da Apneia do Sono/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cholinesterase Inhibitors); 0 (Pesticides); EC 3.1.1.7 (Acetylcholinesterase); JCS58I644W (Chlorpyrifos)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191237


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[PMID]:29254301
[Au] Autor:Shu M; Wang BY; Zhang J; Guo CY; Wang XH
[Ad] Endereço:Orthopedic Surgery Section 4, the 2nd Affiliated of Harbin Medical University, Harbin, China.
[Ti] Título:Analysis of specialized nursing on respiratory functions in thoracotomy patients.
[So] Source:J Biol Regul Homeost Agents;31(4):971-976, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:To analyze the nursing effect on the respiratory function of thoracotomy patients, sixty thoracotomy hospitalized patients were studied. The subjects were divided into a normal group (A) and an observation group (B). The patients in group A received routine nursing only, while those in group B received chest physiotherapy as well as routine nursing. Afterwards, the respiratory function indicators of the two groups were compared and a data analysis was performed. The results showed that the partial pressure of oxygen (PO2) value of the patients in group B was greater than that of the patients in group A while the partial pressure of carbon dioxide (PCO2) value in group B was smaller than that in group A, and there was a significant difference between the two groups (p less than 0.05). The vital capacity under normal circumstances and forced breathing of group B were greater than that of group A and the difference was statistically significant (p less than 0.05). The incidence of complications (atelectasis, respiratory infections, pleural effusion) was statistically significant between the two groups (p less than 0.05). The degree of autonomic respiratory dysfunction in group B was lower than that in group A, and there was a significant difference (p less than 0.05), suggesting that the respiratory function in patients receiving chest physiotherapy improved significantly.
[Mh] Termos MeSH primário: Exercícios Respiratórios/métodos
Drenagem Postural/métodos
Enfermagem em Pós-Anestésico/métodos
Enfermagem em Reabilitação/métodos
Toracotomia/reabilitação
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Massagem/métodos
Meia-Idade
Derrame Pleural/etiologia
Derrame Pleural/prevenção & controle
Atelectasia Pulmonar/etiologia
Atelectasia Pulmonar/prevenção & controle
Respiração
Testes de Função Respiratória
Infecções Respiratórias/etiologia
Infecções Respiratórias/prevenção & controle
Toracotomia/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


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[PMID]:29304152
[Au] Autor:Hu M; Zhai G; Li D; Fan Y; Duan H; Zhu W; Yang X
[Ad] Endereço:Shanghai Institute for Advanced Communication and Data Science, Shanghai Key Laboratory of Digital Media Processing and Transmission, Shanghai Jiao Tong University, Shanghai, China.
[Ti] Título:Combination of near-infrared and thermal imaging techniques for the remote and simultaneous measurements of breathing and heart rates under sleep situation.
[So] Source:PLoS One;13(1):e0190466, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To achieve the simultaneous and unobtrusive breathing rate (BR) and heart rate (HR) measurements during nighttime, we leverage a far-infrared imager and an infrared camera equipped with IR-Cut lens and an infrared lighting array to develop a dual-camera imaging system. A custom-built cascade face classifier, containing the conventional Adaboost model and fully convolutional network trained by 32K images, was used to detect the face region in registered infrared images. The region of interest (ROI) inclusive of mouth and nose regions was afterwards confirmed by the discriminative regression and coordinate conversions of three selected landmarks. Subsequently, a tracking algorithm based on spatio-temporal context learning was applied for following the ROI in thermal video, and the raw signal was synchronously extracted. Finally, a custom-made time-domain signal analysis approach was developed for the determinations of BR and HR. A dual-mode sleep video database, including the videos obtained under environment where illumination intensity ranged from 0 to 3 Lux, was constructed to evaluate the effectiveness of the proposed system and algorithms. In linear regression analysis, the determination coefficient (R2) of 0.831 had been observed for the measured BR and reference BR, and this value was 0.933 for HR measurement. In addition, the Bland-Altman plots of BR and HR demonstrated that almost all the data points located within their own 95% limits of agreement. Consequently, the overall performance of the proposed technique is acceptable for BR and HR estimations during nighttime.
[Mh] Termos MeSH primário: Frequência Cardíaca
Respiração
Sono/fisiologia
Espectroscopia de Luz Próxima ao Infravermelho/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190466


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[PMID]:29371650
[Au] Autor:Sheikhbahaei S; Turovsky EA; Hosford PS; Hadjihambi A; Theparambil SM; Liu B; Marina N; Teschemacher AG; Kasparov S; Smith JC; Gourine AV
[Ad] Endereço:Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, WC1E 6BT, UK.
[Ti] Título:Astrocytes modulate brainstem respiratory rhythm-generating circuits and determine exercise capacity.
[So] Source:Nat Commun;9(1):370, 2018 01 25.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Astrocytes are implicated in modulation of neuronal excitability and synaptic function, but it remains unknown if these glial cells can directly control activities of motor circuits to influence complex behaviors in vivo. This study focused on the vital respiratory rhythm-generating circuits of the preBötzinger complex (preBötC) and determined how compromised function of local astrocytes affects breathing in conscious experimental animals (rats). Vesicular release mechanisms in astrocytes were disrupted by virally driven expression of either the dominant-negative SNARE protein or light chain of tetanus toxin. We show that blockade of vesicular release in preBötC astrocytes reduces the resting breathing rate and frequency of periodic sighs, decreases rhythm variability, impairs respiratory responses to hypoxia and hypercapnia, and dramatically reduces the exercise capacity. These findings indicate that astrocytes modulate the activity of CNS circuits generating the respiratory rhythm, critically contribute to adaptive respiratory responses in conditions of increased metabolic demand and determine the exercise capacity.
[Mh] Termos MeSH primário: Astrócitos/fisiologia
Tronco Encefálico/fisiologia
Periodicidade
Condicionamento Físico Animal/fisiologia
Respiração
[Mh] Termos MeSH secundário: Potenciais de Ação/fisiologia
Adenoviridae/genética
Adenoviridae/metabolismo
Animais
Animais Recém-Nascidos
Astrócitos/citologia
Tronco Encefálico/citologia
Cálcio/metabolismo
Feminino
Regulação da Expressão Gênica
Vetores Genéticos/química
Vetores Genéticos/metabolismo
Hipercapnia/metabolismo
Hipercapnia/fisiopatologia
Hipóxia/metabolismo
Hipóxia/fisiopatologia
Masculino
Bulbo/citologia
Bulbo/fisiologia
Cultura Primária de Células
Ratos
Ratos Sprague-Dawley
Proteínas SNARE/antagonistas & inibidores
Proteínas SNARE/genética
Proteínas SNARE/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (SNARE Proteins); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02723-6



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