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[PMID]:29338164
[Au] Autor:Novkovic D; Petrovic M; Zivkovic V; Baletic N
[Ti] Título:The relation between nonspecific hyperreactivity of the airways and atopic constitution in asthmatics.
[So] Source:Vojnosanit Pregl;73(11):1056-9, 2016 Nov.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Hyperreactivity of the airways caused by inflammation in asthmatics is the most important pathophysiological change. It represents a suitable ground that in the presence of risk factors and the drivers of asthma, asthmatic attack occurs. Atopic constitution is one of the most important risk factors for the development and expression of asthma. The aim of our study was to investigate the relationship between nonspecific airway hyperreactivity and atopic constituton in asthmatics. Methods: This retrospective analysis was conducted considering the results of nonspecific bronchoprovocative test with histamine, skin tests to inhalant allergens and total IgE levels in the serum of asthmatic patients with controlled bronchial asthma. The sample consisted of 162 asthmatics examined during one-year period. Results: The examinees were male asthmatic patients, aged between 18 and 30 years. We found that the examinees with a pronounced non-specific hyperreactivity had more significant skin reaction to inhaled allergens and higher levels of total IgE in serum. Conclusion: The results of our study show that the intensity of airway hyperresponsiveness to histamine in asthmatics is directly related to atopic constitution.
[Mh] Termos MeSH primário: Asma/fisiopatologia
Hiper-Reatividade Brônquica/fisiopatologia
Broncoconstrição
Dermatite Atópica/imunologia
Pulmão/fisiopatologia
[Mh] Termos MeSH secundário: Administração por Inalação
Adolescente
Adulto
Asma/diagnóstico
Asma/imunologia
Biomarcadores/sangue
Hiper-Reatividade Brônquica/diagnóstico
Hiper-Reatividade Brônquica/imunologia
Testes de Provocação Brônquica
Dermatite Atópica/sangue
Dermatite Atópica/diagnóstico
Histamina/administração & dosagem
Seres Humanos
Imunoglobulina E/sangue
Pulmão/imunologia
Masculino
Estudos Retrospectivos
Fatores de Risco
Testes Cutâneos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 37341-29-0 (Immunoglobulin E); 820484N8I3 (Histamine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.2298/VSP141029120N


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[PMID]:28743514
[Au] Autor:Herbert J; Thiermann H; Worek F; Wille T
[Ad] Endereço:Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany.
[Ti] Título:Precision cut lung slices as test system for candidate therapeutics in organophosphate poisoning.
[So] Source:Toxicology;389:94-100, 2017 08 15.
[Is] ISSN:1879-3185
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Standard therapeutic options in organophosphate (OP) poisoning are limited to the administration of atropine and oximes, a regimen often lacking in efficacy and applicability. Treatment alternatives are needed, preferably covering a broad spectrum of OP intoxications. Although recent research yielded several promising compounds, e.g. bioscavengers, modulators of the muscarinic acetylcholine (ACh) receptor or bispyridinium non-oximes, these substances still need further evaluation, especially regarding effects on the potentially lethal respiratory symptoms of OP poisoning. Aim of this study was the development of an applicable and easy method to test the therapeutic efficiency of such substances. For this purpose, airway responsiveness in viable precision cut lung slices (PCLS) from rats was analysed. We showed that ACh-induced airway contractions were spontaneously reversible in non-poisoned PCLS, whereas in OP poisoned PCLS, contractions were irreversible. This effect could be antagonized by addition of the standard therapeutic atropine, thereby presenting a clear indication for treatment efficiency. Now, candidate therapeutic compounds can be evaluated, based on their ability to counteract the irreversible airway contraction in OP poisoned PCLS.
[Mh] Termos MeSH primário: Antídotos/farmacologia
Atropina/farmacologia
Broncoconstrição/efeitos dos fármacos
Broncodilatadores/farmacologia
Descoberta de Drogas/métodos
Pulmão/efeitos dos fármacos
Antagonistas Muscarínicos/farmacologia
Contração Muscular/efeitos dos fármacos
Músculo Liso/efeitos dos fármacos
Agentes Neurotóxicos/toxicidade
Intoxicação por Organofosfatos/tratamento farmacológico
Organofosfatos/toxicidade
[Mh] Termos MeSH secundário: Acetilcolina/farmacologia
Animais
Relação Dose-Resposta a Droga
Pulmão/fisiopatologia
Masculino
Músculo Liso/fisiopatologia
Intoxicação por Organofosfatos/fisiopatologia
Ratos Wistar
Fatores de Tempo
Técnicas de Cultura de Tecidos
Sobrevivência de Tecidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antidotes); 0 (Bronchodilator Agents); 0 (Muscarinic Antagonists); 0 (Nerve Agents); 0 (Organophosphates); 7C0697DR9I (Atropine); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


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[PMID]:28458423
[Au] Autor:Sharma S; Rasal VP; Patil PA; Joshi RK
[Ad] Endereço:Department of Pharmacology, KLE University, College of Pharmacy, Belgaum, Karnataka, India.
[Ti] Título:Effect of essential oil on allergic airway changes induced by histamine and ovalbumin in experimental animals.
[So] Source:Indian J Pharmacol;49(1):55-59, 2017 Jan-Feb.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Edgew (Apiaceae) is used in traditional medicine for treatment of several diseases including bronchial asthma. The present investigation was aimed to evaluate broncho-relaxant activity of essential oil in histamine and ovalbumin (OVA)-induced broncho constriction in experimental animals. MATERIALS AND METHODS: Airway was induced using histamine aerosol in guinea pigs ( = 24) and OVA aerosol in albino mice ( = 24). The number of inflammatory cells, namely, absolute eosinophils count in blood, total immunoglobulin E (IgE) in serum, eosinophils, and neutrophils in bronchoalveolar lavage fluid (BALF) and histopathological examination of lung tissues were investigated in oil and dexamethasone-treated groups. oil 200 µL/kg was given orally, and dexamethasone 2 mg/kg was given intraperitoneal. Both the treatments were repeated daily for 7 days. Results were analyzed by one-way ANOVA, and ≤ 0.05 was considered statistically significant. RESULTS: Treatment with essential oil significantly ( < 0.001) increased the time of preconvulsive dyspnea in histamine-induced guinea pigs. Oral treatment of oil significantly ( < 0.001) decreased absolute blood eosinophil count (from 325 ± 3.69 to 200 ± 3.05 cells/mm ), serum level of IgE (from 6.10 ± 0.05 to 0.70 ± 0.08 IU/L), and the number of eosinophils (from 11.0% ±1.41% to 3.0% ±0.51%), neutrophils (from 13.0% ±1.12% to 5.0% ±1.39%) in BALF. Histopathological changes observed in lungs of untreated group were marked suppressed by treatment with oil. CONCLUSION: The essential oil of has bronchorelaxation in both histamine and OVA-induced bronchoconstriction in animals. The traditional use of against asthma could be attributed to its bronchodilator property as observed in the present study.
[Mh] Termos MeSH primário: Angelica/química
Broncoconstrição/efeitos dos fármacos
Broncodilatadores/farmacologia
Óleos Voláteis/farmacologia
[Mh] Termos MeSH secundário: Administração Oral
Animais
Asma/tratamento farmacológico
Asma/imunologia
Líquido da Lavagem Broncoalveolar
Broncoconstrição/imunologia
Broncodilatadores/administração & dosagem
Broncodilatadores/isolamento & purificação
Dexametasona/farmacologia
Modelos Animais de Doenças
Eosinófilos/efeitos dos fármacos
Eosinófilos/metabolismo
Feminino
Cobaias
Histamina/imunologia
Imunoglobulina E/sangue
Camundongos
Neutrófilos/efeitos dos fármacos
Neutrófilos/metabolismo
Óleos Voláteis/administração & dosagem
Óleos Voláteis/isolamento & purificação
Ovalbumina/imunologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bronchodilator Agents); 0 (Oils, Volatile); 37341-29-0 (Immunoglobulin E); 7S5I7G3JQL (Dexamethasone); 820484N8I3 (Histamine); 9006-59-1 (Ovalbumin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.4103/0253-7613.201019


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[PMID]:28871831
[Au] Autor:Mohamed AR; Georgey HH; George RF; El-Eraky WI; Saleh DO; Abdel Gawad NM
[Ad] Endereço:Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo 11829, Egypt.
[Ti] Título:Identification of some novel xanthine-based derivatives with bronchodilator activity.
[So] Source:Future Med Chem;9(15):1731-1747, 2017 Oct.
[Is] ISSN:1756-8927
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: The discovery of new bronchodilators with higher efficacy than theophylline is an important issue for asthmatic patients. MATERIALS & METHODS: Theophylline 2, 8-bromotheophylline 4 and theobromine 6 were reacted with different 2/3-chloro-N-phenylacetamides 1a-d or their propanamide analogs 1e-g to obtain 3a-g, 5a-g and 7a-g, respectively. The target compounds were screened for their in vitro bronchodilator activity using isolated guinea pig tracheal rings precontracted with histamine and compared with their precursors. RESULTS: Many compounds exhibited promising activity especially 3d, 3f, 5d, 7d and 7e. 2D-QSAR study resulted in a significant model (N = 24, n = 5, R  = 0.848, R cvOO = 0.748, R cvMO = 0.745, F = 21.215, s  = 0.0002) using CODESSA-Pro software. CONCLUSION:  These compounds can be considered as promising hits for potent bronchodilators that may be useful for further investigations. [Formula: see text].
[Mh] Termos MeSH primário: Broncodilatadores/química
Broncodilatadores/farmacologia
Xantinas/química
[Mh] Termos MeSH secundário: Animais
Broncoconstrição/efeitos dos fármacos
Broncodilatadores/síntese química
Cobaias
Histamina/toxicidade
Concentração Inibidora 50
Relação Quantitativa Estrutura-Atividade
Traqueia/efeitos dos fármacos
Traqueia/fisiologia
Xantinas/síntese química
Xantinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bronchodilator Agents); 0 (Xanthines); 820484N8I3 (Histamine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.4155/fmc-2017-0092


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[PMID]:28857808
[Au] Autor:Kretzschmar M; Kozian A; Baumgardner JE; Borges JB; Hedenstierna G; Larsson A; Hachenberg T; Schilling T
[Ad] Endereço:From the Hedenstierna Laboratory, Department of Surgical Sciences (M.K., A.K., J.B.B., A.L., T.S.), and Clinical Physiology, Department of Medical Sciences (G.H.), Uppsala University, Uppsala, Sweden; Department of Anesthesiology and Intensive Care Medicine, Otto von Guericke University Magdeburg, Magdeburg, Germany (M.K., A.K., T.H., T.S.); Oscillogy LLC, Pittsburgh, Pennsylvania (J.E.B.); and Department of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (J.E.B.).
[Ti] Título:Effect of Bronchoconstriction-induced Ventilation-Perfusion Mismatch on Uptake and Elimination of Isoflurane and Desflurane.
[So] Source:Anesthesiology;127(5):800-812, 2017 Nov.
[Is] ISSN:1528-1175
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Increasing numbers of patients with obstructive lung diseases need anesthesia for surgery. These conditions are associated with pulmonary ventilation/perfusion (VA/Q) mismatch affecting kinetics of volatile anesthetics. Pure shunt might delay uptake of less soluble anesthetic agents but other forms of VA/Q scatter have not yet been examined. Volatile anesthetics with higher blood solubility would be less affected by VA/Q mismatch. We therefore compared uptake and elimination of higher soluble isoflurane and less soluble desflurane in a piglet model. METHODS: Juvenile piglets (26.7 ± 1.5 kg) received either isoflurane (n = 7) or desflurane (n = 7). Arterial and mixed venous blood samples were obtained during wash-in and wash-out of volatile anesthetics before and during bronchoconstriction by methacholine inhalation (100 µg/ml). Total uptake and elimination were calculated based on partial pressure measurements by micropore membrane inlet mass spectrometry and literature-derived partition coefficients and assumed end-expired to arterial gradients to be negligible. VA/Q distribution was assessed by the multiple inert gas elimination technique. RESULTS: Before methacholine inhalation, isoflurane arterial partial pressures reached 90% of final plateau within 16 min and decreased to 10% after 28 min. By methacholine nebulization, arterial uptake and elimination delayed to 35 and 44 min. Desflurane needed 4 min during wash-in and 6 min during wash-out, but with bronchoconstriction 90% of both uptake and elimination was reached within 15 min. CONCLUSIONS: Inhaled methacholine induced bronchoconstriction and inhomogeneous VA/Q distribution. Solubility of inhalational anesthetics significantly influenced pharmacokinetics: higher soluble isoflurane is less affected than fairly insoluble desflurane, indicating different uptake and elimination during bronchoconstriction.
[Mh] Termos MeSH primário: Anestésicos Inalatórios/sangue
Broncoconstrição/fisiologia
Isoflurano/análogos & derivados
Isoflurano/sangue
Ventilação Pulmonar/fisiologia
Relação Ventilação-Perfusão/fisiologia
[Mh] Termos MeSH secundário: Anestésicos Inalatórios/administração & dosagem
Animais
Animais Recém-Nascidos
Isoflurano/administração & dosagem
Ventilação Pulmonar/efeitos dos fármacos
Respiração Artificial/métodos
Suínos
Relação Ventilação-Perfusão/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); CRS35BZ94Q (desflurane); CYS9AKD70P (Isoflurane)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1097/ALN.0000000000001847


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[PMID]:28829345
[Au] Autor:Bougault V; Drouard F; Legall F; Dupont G; Wallaert B
[Ad] Endereço:*Department of Sport Sciences and Physical Education, University of Lille, EA7369, URePSSS Unité de Recherche Pluridisciplinaire Sport, Santé, Société, Lille, France;†LOSC Lille, Research Department, Lille, France; and‡CHU Lille, Service de Pneumologie et immuno-allergologie, Hôpital Calmette et Université de Lille 2, France.
[Ti] Título:Allergies and Exercise-Induced Bronchoconstriction in a Youth Academy and Reserve Professional Soccer Team.
[So] Source:Clin J Sport Med;27(5):450-456, 2017 Sep.
[Is] ISSN:1536-3724
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: A high prevalence of respiratory allergies and exercise-induced bronchoconstriction (EIB) has been reported among endurance athletes. This study was designed to analyze the frequency of sensitization to respiratory allergens and EIB in young soccer players. DESIGN: Prospective cohort design. SETTING: Youth academy and reserve professional soccer team during the seasons 2012 to 2013 and 2013 to 2014. PARTICIPANTS: Eighty-five soccer players (mean age: 20 ± 4 years) participated. INTERVENTION: Players underwent skin prick tests (SPTs) during the seasons 2012 to 2013 and 2013 to 2014. Spirometry and a eucapnic voluntary hyperpnea test were performed on soccer players during the first season 2012 to 2013 (n = 51) to detect EIB. Two self-administered questionnaires on respiratory history and allergic symptoms (European Community Respiratory Health Survey and Allergy Questionnaire for Athletes) were also distributed during both seasons (n = 59). MAIN OUTCOME MEASURES: The number of positive SPTs, exercise-induced respiratory symptoms, presence of asthma, airway obstruction, and EIB. RESULTS: Forty-nine percent of players were sensitized to at least one respiratory allergen, 33% reported an allergic disease, 1 player presented airway obstruction at rest, and 16% presented EIB. Factors predictive of EIB were self-reported exercise-induced symptoms and sensitization to at least 5 allergens. CONCLUSIONS: Questioning players about exercise-induced respiratory symptoms and allergies as well as spirometry at the time of the inclusion medical checkup would improve management of respiratory health of soccer players and would constitute inexpensive preliminary screening to select players requiring indirect bronchial provocation test or SPTs. CLINICAL RELEVANCE: This study showed that despite low frequencies, EIB and allergies are underdiagnosed and undertreated in young soccer players.
[Mh] Termos MeSH primário: Asma Induzida por Exercício/epidemiologia
Broncoconstrição
Hipersensibilidade/epidemiologia
Futebol
[Mh] Termos MeSH secundário: Adolescente
Adulto
Atletas
Seres Humanos
Prevalência
Estudos Prospectivos
Testes Cutâneos
Espirometria
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1097/JSM.0000000000000393


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[PMID]:28644040
[Au] Autor:Kelly VJ; Hibbert KA; Kohli P; Kone M; Greenblatt EE; Venegas JG; Winkler T; Harris RS
[Ad] Endereço:1 Division of Pulmonary and Critical Care Medicine, Department of Medicine, and.
[Ti] Título:Hypoxic Pulmonary Vasoconstriction Does Not Explain All Regional Perfusion Redistribution in Asthma.
[So] Source:Am J Respir Crit Care Med;196(7):834-844, 2017 Oct 01.
[Is] ISSN:1535-4970
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Regional hypoventilation in bronchoconstricted patients with asthma is spatially associated with reduced perfusion, which is proposed to result from hypoxic pulmonary vasoconstriction (HPV). OBJECTIVES: To determine the role of HPV in the regional perfusion redistribution in bronchoconstricted patients with asthma. METHODS: Eight patients with asthma completed positron emission tomographic/computed tomographic lung imaging at baseline and after bronchoconstriction, breathing either room air or 80% oxygen (80% O ) on separate days. Relative perfusion, specific ventilation (sV), and gas fraction (Fgas) in the 25% of the lung with the lowest specific ventilation (sV ) and the remaining lung (sV ) were quantified and compared. MEASUREMENTS AND MAIN RESULTS: In the sV region, bronchoconstriction caused a significant decrease in sV under both room air and 80% O conditions (baseline vs. bronchoconstriction, mean ± SD, 1.02 ± 0.20 vs. 0.35 ± 0.19 and 1.03 ± 0.20 vs. 0.32 ± 0.16, respectively; P < 0.05). In the sV region, relative perfusion decreased after bronchoconstriction under room air conditions and also, to a lesser degree, under 80% O conditions (1.02 ± 0.19 vs. 0.72 ± 0.08 [P < 0.001] and 1.08 ± 0.19 vs. 0.91 ± 0.12 [P < 0.05], respectively). The Fgas increased after bronchoconstriction under room air conditions only (0.99 ± 0.04 vs. 1.00 ± 0.02; P < 0.05). The sV subregion analysis indicated that some of the reduction in relative perfusion after bronchoconstriction under 80% O conditions occurred as a result of the presence of regional hypoxia. However, relative perfusion was also significantly reduced in sV subregions that were hyperoxic under 80% O conditions. CONCLUSIONS: HPV is not the only mechanism that contributes to perfusion redistribution in bronchoconstricted patients with asthma, suggesting that another nonhypoxia mechanism also contributes. We propose that this nonhypoxia mechanism may be either direct mechanical interactions and/or unidentified intercellular signaling between constricted airways, the parenchyma, and the surrounding vasculature.
[Mh] Termos MeSH primário: Asma/fisiopatologia
Hipóxia/fisiopatologia
Pulmão/fisiopatologia
Circulação Pulmonar/fisiologia
Vasoconstrição/fisiologia
[Mh] Termos MeSH secundário: Adulto
Asma/diagnóstico por imagem
Broncoconstrição/fisiologia
Feminino
Seres Humanos
Pulmão/irrigação sanguínea
Pulmão/diagnóstico por imagem
Masculino
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.1164/rccm.201612-2438OC


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[PMID]:28606216
[Au] Autor:Williams NC; Hunter KA; Shaw DE; Jackson KG; Sharpe GR; Johnson MA
[Ad] Endereço:1Exercise and Health Research Group,Department of Sport Science,Sport, Health and Performance Enhancement (SHAPE) Research Centre,Nottingham Trent University,Nottingham NG11 8NS,UK.
[Ti] Título:Comparable reductions in hyperpnoea-induced bronchoconstriction and markers of airway inflammation after supplementation with 6·2 and 3·1 g/d of long-chain n-3 PUFA in adults with asthma.
[So] Source:Br J Nutr;117(10):1379-1389, 2017 May.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although high dose n-3 PUFA supplementation reduces exercise- and hyperpnoea-induced bronchoconstriction (EIB/HIB), there are concurrent issues with cost, compliance and gastrointestinal discomfort. It is thus pertinent to establish the efficacy of lower n-3 PUFA doses. Eight male adults with asthma and HIB and eight controls without asthma were randomly supplemented with two n-3 PUFA doses (6·2 g/d (3·7 g EPA and 2·5 g DHA) and 3·1 g/d (1·8 g EPA and 1·3 g DHA)) and a placebo, each for 21 d followed by 14 d washout. A eucapnic voluntary hyperpnoea (EVH) challenge was performed before and after treatments. Outcome measures remained unchanged in the control group. In the HIB group, the peak fall in forced expiratory volume in 1 s (FEV1) after EVH at day 0 (-1005 (sd 520) ml, -30 (sd 18) %) was unchanged after placebo. The peak fall in FEV1 was similarly reduced from day 0 to day 21 of 6·2 g/d n-3 PUFA (-1000 (sd 460) ml, -29 (sd 17) % v. -690 (sd 460) ml, -20 (sd 15) %) and 3·1 g/d n-3 PUFA (-970 (sd 480) ml, -28 (sd 18) % v. -700 (sd 420) ml, -21 (sd 15) %) (P<0·001). Baseline fraction of exhaled nitric oxide was reduced by 24 % (P=0·020) and 31 % (P=0·018) after 6·2 and 3·1 g/d n-3 PUFA, respectively. Peak increases in 9α, 11ß PGF2 after EVH were reduced by 65 % (P=0·009) and 56 % (P=0·041) after 6·2 and 3·1 g/d n-3 PUFA, respectively. In conclusion, 3·1 g/d n-3 PUFA supplementation attenuated HIB and markers of airway inflammation to a similar extent as a higher dose. Lower doses of n-3 PUFA thus represent a potentially beneficial adjunct treatment for adults with asthma and EIB.
[Mh] Termos MeSH primário: Asma/tratamento farmacológico
Broncoconstrição/efeitos dos fármacos
Suplementos Nutricionais
Ácidos Graxos Ômega-3/farmacologia
Inflamação/metabolismo
[Mh] Termos MeSH secundário: Adulto
Biomarcadores
Relação Dose-Resposta a Droga
Ácidos Graxos Ômega-3/administração & dosagem
Seres Humanos
Inflamação/patologia
Masculino
Fosfolipídeos/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Fatty Acids, Omega-3); 0 (Phospholipids)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517001246


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[PMID]:28603132
[Au] Autor:Alam F; Saqib QN; Shah AJ
[Ad] Endereço:Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan.
[Ti] Título:Airways and vascular smooth muscles relaxant activities of Gaultheria trichophylla.
[So] Source:Pak J Pharm Sci;30(1):199-203, 2017 Jan.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The aim of this experimental work was to explore the potential pharmacological activities of Gaultheria trichophylla Royle in hyperactive respiratory and vascular conditions. Gaultheria trichophylla was extracted with solvents, phytochemical detection tests were performed, and rabbit trachea and aorta strips were used to evaluate its effects on airways and vascular smooth muscles. Qualitative phytochemical tests showed the presence of flavonoids, alkaloids, anthraquinones, saponins, terpenoids, and condensed tannins. The methanol extract caused inhibition (EC values of 3.12 mg/mL) of carbachol (1 µM) and partial relaxation of K (80 mM) caused contractions in tracheal strips. The chloroform extract was comparatively more potent against carbachol than K+ induced contraction with EC values of 0.64 and 2.26 mg/mL, respectively. However, the n-hexane extract showed more potency against K than cabachol induced contractions, as in case with verapamil, with EC values of 0.61 and 6.58 mg/mL, respectively. In isolated prepared trachea, the extracts displaced the carbachol concentration response curves and maximum response was suppressed. In rabbit aorta preparations, methanol and n-hexane extracts partially relaxed phenylephrine (1 µM) and K induced vasoconstrictions. However, the chloroform extract inhibited phenylephrine induced contractions and exhibited a vasoconstrictor effect at lower concentrations and a relaxant effect at higher concentrations against K precontractions. The data indicates that, in addition to others, the extracts of G .trichophylla possess verapamil like Ca channel blocking components which explain the possible role of this plant in respiratory and vascular conditions.
[Mh] Termos MeSH primário: Broncoconstrição/efeitos dos fármacos
Broncodilatadores/farmacologia
Bloqueadores dos Canais de Cálcio/farmacologia
Gaultheria/química
Músculo Liso Vascular/efeitos dos fármacos
Extratos Vegetais/farmacologia
Traqueia/efeitos dos fármacos
Vasodilatação/efeitos dos fármacos
Vasodilatadores/farmacologia
[Mh] Termos MeSH secundário: Animais
Aorta/efeitos dos fármacos
Aorta/metabolismo
Broncodilatadores/isolamento & purificação
Bloqueadores dos Canais de Cálcio/isolamento & purificação
Canais de Cálcio/efeitos dos fármacos
Canais de Cálcio/metabolismo
Clorofórmio/química
Relação Dose-Resposta a Droga
Feminino
Hexanos/química
Técnicas In Vitro
Masculino
Metanol/química
Músculo Liso Vascular/metabolismo
Compostos Fitoquímicos/isolamento & purificação
Compostos Fitoquímicos/farmacologia
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Coelhos
Solventes/química
Traqueia/metabolismo
Vasodilatadores/isolamento & purificação
Verapamil/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bronchodilator Agents); 0 (Calcium Channel Blockers); 0 (Calcium Channels); 0 (Hexanes); 0 (Phytochemicals); 0 (Plant Extracts); 0 (Solvents); 0 (Vasodilator Agents); 2DDG612ED8 (n-hexane); 7V31YC746X (Chloroform); CJ0O37KU29 (Verapamil); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


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[PMID]:28596292
[Au] Autor:Kistemaker LEM; Oenema TA; Baarsma HA; Bos IST; Schmidt M; Facchinetti F; Civelli M; Villetti G; Gosens R
[Ad] Endereço:Department of Molecular Pharmacology, University of Groningen, The Netherlands; l.e.m.kistemaker@rug.nl.
[Ti] Título:The PDE4 inhibitor CHF-6001 and LAMAs inhibit bronchoconstriction-induced remodeling in lung slices.
[So] Source:Am J Physiol Lung Cell Mol Physiol;313(3):L507-L515, 2017 Sep 01.
[Is] ISSN:1522-1504
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Combination therapy of PDE4 inhibitors and anticholinergics induces bronchoprotection in COPD. Mechanical forces that arise during bronchoconstriction may contribute to airway remodeling. Therefore, we investigated the impact of PDE4 inhibitors and anticholinergics on bronchoconstriction-induced remodeling. Because of the different mechanism of action of PDE4 inhibitors and anticholinergics, we hypothesized functional interactions of these two drug classes. Guinea pig precision-cut lung slices were preincubated with the PDE4 inhibitors CHF-6001 or roflumilast and/or the anticholinergics tiotropium or glycopyorrolate, followed by stimulation with methacholine (10 µM) or TGF-ß (2 ng/ml) for 48 h. The inhibitory effects on airway smooth muscle remodeling, airway contraction, and TGF-ß release were investigated. Methacholine-induced protein expression of smooth muscle-myosin was fully inhibited by CHF-6001 (0.3-100 nM), whereas roflumilast (1 µM) had smaller effects. Tiotropium and glycopyrrolate fully inhibited methacholine-induced airway remodeling (0.1-30 nM). The combination of CHF-6001 and tiotropium or glycopyrrolate, in concentrations partially effective by themselves, fully inhibited methacholine-induced remodeling in combination. CHF-6001 did not affect airway closure and had limited effects on TGF-ß -induced remodeling, but rather, it inhibited methacholine-induced TGF-ß release. The PDE4 inhibitor CHF-6001, and to a lesser extent roflumilast, and the LAMAs tiotropium and glycopyrrolate inhibit bronchoconstriction-induced remodeling. The combination of CHF-6001 and anticholinergics was more effective than the individual compounds. This cooperativity might be explained by the distinct mechanisms of action inhibiting TGF-ß release and bronchoconstriction.
[Mh] Termos MeSH primário: Remodelação das Vias Aéreas/efeitos dos fármacos
Broncoconstrição/efeitos dos fármacos
Antagonistas Colinérgicos/farmacologia
Nucleotídeo Cíclico Fosfodiesterase do Tipo 4/metabolismo
Pulmão/efeitos dos fármacos
Pulmão/fisiopatologia
Inibidores da Fosfodiesterase 4/farmacologia
Sulfonamidas/farmacologia
para-Aminobenzoatos/farmacologia
[Mh] Termos MeSH secundário: Aminopiridinas
Animais
Benzamidas
Ciclopropanos
Interações Medicamentosas
Glicopirrolato/farmacologia
Cobaias
Masculino
Cloreto de Metacolina/farmacologia
Brometo de Tiotrópio/farmacologia
Fator de Crescimento Transformador beta/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)ethyl)pyridine 1-oxide); 0 (Aminopyridines); 0 (Benzamides); 0 (Cholinergic Antagonists); 0 (Cyclopropanes); 0 (Phosphodiesterase 4 Inhibitors); 0 (Sulfonamides); 0 (Transforming Growth Factor beta); 0 (para-Aminobenzoates); 0P6C6ZOP5U (Roflumilast); 0W5ETF9M2K (Methacholine Chloride); EC 3.1.4.17 (Cyclic Nucleotide Phosphodiesterases, Type 4); V92SO9WP2I (Glycopyrrolate); XX112XZP0J (Tiotropium Bromide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.1152/ajplung.00069.2017



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