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[PMID]:28452210
[Au] Autor:Talley NJ
[Ad] Endereço:Faculty of Health and Medicine, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia.
[Ti] Título:Functional Dyspepsia: Advances in Diagnosis and Therapy.
[So] Source:Gut Liver;11(3):349-357, 2017 May 15.
[Is] ISSN:2005-1212
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Functional dyspepsia (FD) is a common but under-recognized syndrome comprising bothersome recurrent postprandial fullness, early satiety, or epigastric pain/burning. Epidemiologically, there are two clinically distinct FD syndromes (although these often overlap clinically): postprandial distress syndrome (PDS; comprising early satiety or meal-related fullness) and epigastric pain syndrome. Symptoms of gastroesophageal reflux disease overlap with FD more than expected by chance; a subset has pathological acid reflux. The pretest probability of FD in a patient who presents with classical FD symptoms and no alarm features is high, approximately 0.7. Coexistent heartburn should not lead to the exclusion of FD as a diagnosis. One of the most exciting observations in FD has been the consistent finding of increased duodenal eosinophilia, notably in PDS. Small bowel homing T cells, signaling intestinal inflammation, and increased cytokines have been detected in the circulation, and elevated tumor necrosis factor-α levels have been significantly correlated with increased anxiety. Postinfectious gastroenteritis is a risk factor for FD. Therapeutic options remain limited and provide only symptomatic benefit in most cases. Only one therapy is known to change the natural history of FD- eradication. Treatment of duodenal eosinophilia is under investigation.
[Mh] Termos MeSH primário: Dispepsia/diagnóstico
Dispepsia/terapia
Período Pós-Prandial
Avaliação de Sintomas
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Duodenopatias/complicações
Duodenopatias/diagnóstico
Dispepsia/etiologia
Eosinofilia/complicações
Eosinofilia/diagnóstico
Refluxo Gastroesofágico/complicações
Refluxo Gastroesofágico/diagnóstico
Azia/complicações
Azia/diagnóstico
Infecções por Helicobacter/complicações
Infecções por Helicobacter/tratamento farmacológico
Helicobacter pylori
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.5009/gnl16055


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[PMID]:29403335
[Au] Autor:Wong SH; Turbin RE; Frohman LP
[Ad] Endereço:Institute of Ophthalmology & Visual Science, Rutgers New Jersey Medical School, Newark.
[Ti] Título:Takayasu arteritis-related photic and postprandial amaurosis.
[So] Source:Digit J Ophthalmol;23(4):13-14, 2017.
[Is] ISSN:1542-8958
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We report the case of a 66-year-old man with Takayasu arteritis who developed photic and postprandial amaurosis occurring at a corticosteroid dose <40 mg per day, despite concurrent methotrexate. The amaurosis resolved with correction of anemia by packed red blood cell transfusion. Marginal retinal perfusion in Takayasu arteritis may precipitate symptomatic hypoxia as a result of eating a meal or exposing the eye to bright lights. Correction of anemia improves oxygen delivery to the hypoxic retina and relieves recurrent amaurosis.
[Mh] Termos MeSH primário: Cegueira/etiologia
Período Pós-Prandial
Arterite de Takayasu/complicações
[Mh] Termos MeSH secundário: Idoso
Artéria Axilar/diagnóstico por imagem
Cegueira/diagnóstico
Cegueira/fisiopatologia
Diagnóstico Diferencial
Angiofluoresceinografia/métodos
Fundo de Olho
Seres Humanos
Angiografia por Ressonância Magnética
Masculino
Vasos Retinianos/diagnóstico por imagem
Artéria Subclávia/diagnóstico por imagem
Arterite de Takayasu/diagnóstico
Acuidade Visual
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.5693/djo.02.2017.09.002


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[PMID]:29385178
[Au] Autor:Parvaresh Rizi E; Loh TP; Baig S; Chhay V; Huang S; Caleb Quek J; Tai ES; Toh SA; Khoo CM
[Ad] Endereço:Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
[Ti] Título:A high carbohydrate, but not fat or protein meal attenuates postprandial ghrelin, PYY and GLP-1 responses in Chinese men.
[So] Source:PLoS One;13(1):e0191609, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It is known that the macronutrient content of a meal has different impacts on the postprandial satiety and appetite hormonal responses. Whether obesity interacts with such nutrient-dependent responses is not well characterized. We examined the postprandial appetite and satiety hormonal responses after a high-protein (HP), high-carbohydrate (HC), or high-fat (HF) mixed meal. This was a randomized cross-over study of 9 lean insulin-sensitive (mean±SEM HOMA-IR 0.83±0.10) and 9 obese insulin-resistant (HOMA-IR 4.34±0.41) young (age 21-40 years), normoglycaemic Chinese men. We measured fasting and postprandial plasma concentration of glucose, insulin, active glucagon-like peptide-1 (GLP-1), total peptide-YY (PYY), and acyl-ghrelin in response to HP, HF, or HC meals. Overall postprandial plasma insulin response was more robust in the lean compared to obese subjects. The postprandial GLP-1 response after HF or HP meal was higher than HC meal in both lean and obese subjects. In obese subjects, HF meal induced higher response in postprandial PYY compared to HC meal. HP and HF meals also suppressed ghrelin greater compared to HC meal in the obese than lean subjects. In conclusion, a high-protein or high-fat meal induces a more favorable postprandial satiety and appetite hormonal response than a high-carbohydrate meal in obese insulin-resistant subjects.
[Mh] Termos MeSH primário: Carboidratos da Dieta/administração & dosagem
Gorduras na Dieta/administração & dosagem
Proteínas na Dieta/administração & dosagem
Grelina/sangue
Peptídeo 1 Semelhante ao Glucagon/sangue
Peptídeo YY/sangue
[Mh] Termos MeSH secundário: Adulto
Grupo com Ancestrais do Continente Asiático
Glicemia/metabolismo
Estudos Cross-Over
Dieta Hiperlipídica
Dieta Rica em Proteínas
Seres Humanos
Insulina/sangue
Resistência à Insulina
Masculino
Obesidade/sangue
Obesidade/dietoterapia
Período Pós-Prandial/fisiologia
Resposta de Saciedade/fisiologia
Singapura
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Dietary Carbohydrates); 0 (Dietary Fats); 0 (Dietary Proteins); 0 (Ghrelin); 0 (Insulin); 106388-42-5 (Peptide YY); 89750-14-1 (Glucagon-Like Peptide 1)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191609


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[PMID]:29441923
[Au] Autor:Debeljak J; Ferk P; Cokolic M; Zavratnik A; Tavc Benkovic E; Kreft S; Strukelj B
[Ti] Título:Randomised, double blind, cross-over, placebo and active controlled human pharmacodynamic study on the influence of silver fir wood extract (Belinal) on post-prandial glycemic response.
[So] Source:Pharmazie;71(10):566-569, 2016 Oct 01.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to test the extract from silver fir wood (Belinal) on the reduction of the blood glucose concentrations after consumption of a standard meal. 31 healthy participants consumed 100 g of white bread 4 times (with 1 week washout period, consequently) concomitantly with a capsule of Belinal, capsule of chestnut wood extract, placebo or acarbose (active control). Glucose and insulin in the blood were measured before and after the meal. The area under the curve of glucose concentration in blood after the meal was 35 % lower when Belinal was added compared with the placebo group (p = 0.019). Acarbose lowered the area for 43 % (p = 0.002). By this, we proved that the effect of Belinal might be beneficial for prevention of diabetes. This is the first study that provides a scientific rationale for use of silver fir wood extract as food supplement for reduction of health risks connected to type 2 diabetes mellitus.
[Mh] Termos MeSH primário: Abies/química
Glicemia/metabolismo
Hipoglicemiantes/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Adulto
Estudos Cross-Over
Método Duplo-Cego
Feminino
Índice Glicêmico
Voluntários Saudáveis
Seres Humanos
Insulina/sangue
Masculino
Período Pós-Prandial/efeitos dos fármacos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Insulin); 0 (Plant Extracts)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6658


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[PMID]:28282751
[Au] Autor:Cockcroft EJ; Williams CA; Jackman SR; Bassi S; Armstrong N; Barker AR
[Ad] Endereço:a Children's Health and Exercise Research Centre, Sport and Health Sciences, College of Life and Environmental Sciences , University of Exeter , Exeter , UK.
[Ti] Título:A single bout of high-intensity interval exercise and work-matched moderate-intensity exercise has minimal effect on glucose tolerance and insulin sensitivity in 7- to 10-year-old boys.
[So] Source:J Sports Sci;36(2):149-155, 2018 Jan.
[Is] ISSN:1466-447X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to assess the acute effect of high-intensity interval exercise (HIIE) and moderate-intensity exercise (MIE) on glucose tolerance, insulin sensitivity and fat oxidation in young boys. Eleven boys (8.8 ± 0.8 y) completed three conditions: 1) HIIE; 2) work-matched MIE; and 3) rest (CON) followed by an oral glucose tolerance test (OGTT) to determine glucose tolerance and insulin sensitivity (Cederholm index). Fat oxidation was measured following the OGTT using indirect calorimetry. There was no effect for condition on plasma [glucose] and [insulin] area under the curve (AUC) responses following the OGTT (P > 0.09). However, there was a "trend" for a condition effect for insulin sensitivity with a small increase after HIIE (P = 0.04, ES = 0.28, 9.7%) and MIE (P = 0.07, ES = 0.21, 6.5%) compared to CON. There was an increase in fat oxidation AUC following HIIE (P = 0.008, ES = 0.79, 38.9%) compared to CON, but with no differences between MIE and CON and HIIE and MIE (P > 0.13). In conclusion, 7- to 10-year-old boys may have limited scope to improve insulin sensitivity and glucose tolerance after a single bout of HIIE and MIE. However, fat oxidation is augmented after HIIE but not MIE.
[Mh] Termos MeSH primário: Glicemia/metabolismo
Exercício/fisiologia
Treinamento Intervalado de Alta Intensidade
Resistência à Insulina/fisiologia
Insulina/sangue
[Mh] Termos MeSH secundário: Área Sob a Curva
Calorimetria Indireta
Criança
Estudos Cross-Over
Metabolismo Energético
Teste de Tolerância a Glucose
Seres Humanos
Metabolismo dos Lipídeos
Masculino
Oxirredução
Período Pós-Prandial/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Insulin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE
[do] DOI:10.1080/02640414.2017.1287934


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[PMID]:29310631
[Au] Autor:Chusak C; Thilavech T; Henry CJ; Adisakwattana S
[Ad] Endereço:Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, 154 Rama 1 Rd., Wangmai, Pathumwan, Bangkok, 10330, Thailand.
[Ti] Título:Acute effect of Clitoria ternatea flower beverage on glycemic response and antioxidant capacity in healthy subjects: a randomized crossover trial.
[So] Source:BMC Complement Altern Med;18(1):6, 2018 Jan 08.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Clitoria ternatea L., a natural food-colorant containing anthocyanin, demonstrated antioxidant and antihyperglycemic activity. The aim of this study was to determine the effects of Clitoria ternatea flower extract (CTE) on postprandial plasma glycemia response and antioxidant status in healthy men. METHODS: In a randomized, crossover study, 15 healthy men (ages 22.53 ± 0.30 years; with body mass index of 21.57 ± 0.54 kg/m ) consumed five beverages: (1) 50 g sucrose in 400 mL water; (2) 1 g CTE in 400 mL of water; (3) 2 g CTE in 400 mL of water; (4) 50 g sucrose and 1 g CTE in 400 mL of water; and (5) 50 g sucrose and 2 g CTE in 400 mL of water. Incremental postprandial plasma glucose, insulin, uric acid, antioxidant capacities and lipid peroxidation were measured during 3 h of administration. RESULTS: After 30 min ingestion, the postprandial plasma glucose and insulin levels were suppressed when consuming sucrose plus 1 g and 2 g CTE. In addition, consumption of CTE alone did not alter plasma glucose and insulin concentration in the fasting state. The significant increase in plasma antioxidant capacity (ferric reducing ability of plasma (FRAP), oxygen radical absorbance capacity (ORAC), trolox equivalent antioxidant capacity (TEAC), and protein thiol) and the decrease in malondialdehyde (MDA) level were observed in the subjects who received 1 g and 2 g CTE. Furthermore, consumption of CTE protected sucrose-induced reduction in ORAC and TEAC and increase in plasma MDA. CONCLUSIONS: These findings suggest that an acute ingestion of CTE increases plasma antioxidant capacity without hypoglycemia in the fasting state. It also improves postprandial glucose, insulin and antioxidant status when consumed with sucrose. TRIAL REGISTRATION: Thai Clinical Trials Registry: TCTR20170609003 . Registered 09 September 2017. 'retrospectively registered'.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Glicemia/efeitos dos fármacos
Clitoria/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Adulto
Antioxidantes/administração & dosagem
Bebidas
Estudos Cross-Over
Seres Humanos
Insulina/sangue
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Extratos Vegetais/administração & dosagem
Período Pós-Prandial
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antioxidants); 0 (Blood Glucose); 0 (Insulin); 0 (Plant Extracts)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2075-7


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[PMID]:27776536
[Au] Autor:Sanchez-Aguadero N; Garcia-Ortiz L; Patino-Alonso MC; Mora-Simon S; Gomez-Marcos MA; Alonso-Dominguez R; Sanchez-Salgado B; Recio-Rodriguez JI
[Ad] Endereço:Primary Care Research Unit, The Alamedilla Health Centre, Castilla and León Health Service (SACYL), Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain. natalia.san.ag@gmail.com.
[Ti] Título:Postprandial effect of breakfast glycaemic index on vascular function, glycaemic control and cognitive performance (BGI study): study protocol for a randomised crossover trial.
[So] Source:Trials;17(1):516, 2016 10 24.
[Is] ISSN:1745-6215
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Postprandial glycaemic response affects cognitive and vascular function. The acute effect of breakfast glycaemic index on vascular parameters is not sufficiently known. Also, the influence of breakfasts with different glycaemic index on cognitive performance has been mostly studied in children and adolescents with varying results. Therefore, the purpose of this study is to analyse the postprandial effect of high and low glycaemic index breakfasts on vascular function and cognitive performance and their relationship with postprandial glycaemic response in healthy young adults. METHODS/DESIGN: This is a crossover clinical trial targeting adults (aged 20-40 years, free from cardiovascular disease) selected by consecutive sampling at urban primary care health clinics in Salamanca (Spain). Each subject will complete three interventions with a washout period of one week: a control condition (consisting of water); a low glycaemic index breakfast (consisting of dark chocolate, walnuts, yogurt and an apple, with an overall glycaemic index of 29.4 and an energy contribution of 1489 kJ); and a high glycaemic index breakfast (consisting of bread, grape juice and strawberry jam, with an overall glycaemic index of 64.0 and an energy contribution of 1318 kJ). The postprandial effect will be assessed at 60 and 120 minutes from each breakfast including blood sampling and cognitive performance evaluations. Measurements of arterial stiffness and central haemodynamic parameters will be taken at -10, 0, 15, 30, 45, 60, 75, 90, 105 and 120 minutes. DISCUSSION: The differences in postprandial glycaemic response due to breakfast glycaemic index could affect vascular parameters and cognitive performance with important applications and implications for the general population. This could provide necessary information for the establishment of new strategies in terms of nutritional education and work performance improvement. TRIAL REGISTRATION: ClinicalTrials.gov:  NCT02616276 . Registered on 19 November 2015.
[Mh] Termos MeSH primário: Glicemia/metabolismo
Desjejum
Cognição
Índice Glicêmico
Hemodinâmica
Período Pós-Prandial
Rigidez Vascular
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/sangue
Protocolos Clínicos
Estudos Cross-Over
Ingestão de Energia
Feminino
Seres Humanos
Masculino
Projetos de Pesquisa
Espanha
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Blood Glucose)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE


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[PMID]:28470119
[Au] Autor:Versteeg RI; Stenvers DJ; Visintainer D; Linnenbank A; Tanck MW; Zwanenburg G; Smilde AK; Fliers E; Kalsbeek A; Serlie MJ; la Fleur SE; Bisschop PH
[Ad] Endereço:Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
[Ti] Título:Acute Effects of Morning Light on Plasma Glucose and Triglycerides in Healthy Men and Men with Type 2 Diabetes.
[So] Source:J Biol Rhythms;32(2):130-142, 2017 Apr.
[Is] ISSN:1552-4531
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ambient light intensity is signaled directly to hypothalamic areas that regulate energy metabolism. Observational studies have shown associations between ambient light intensity and plasma glucose and lipid levels, but human data on the acute metabolic effects of light are scarce. Since light is the main signal indicating the onset of the diurnal phase of physical activity and food intake in humans, we hypothesized that bright light would affect glucose and lipid metabolism. Therefore, we determined the acute effects of bright light on plasma glucose and lipid concentrations in 2 randomized crossover trials: (1) in 8 healthy lean men and (2) in 8 obese men with type 2 diabetes. From 0730 h, subjects were exposed to either bright light (4000 lux) or dim light (10 lux) for 5 h. After 1 h of light exposure, subjects consumed a 600-kcal mixed meal. Primary endpoints were fasting and postprandial plasma glucose levels. In healthy men, bright light did not affect fasting or postprandial plasma glucose levels. However, bright light increased fasting and postprandial plasma triglycerides. In men with type 2 diabetes, bright light increased fasting and postprandial glucose levels. In men with type 2 diabetes, bright light did not affect fasting triglyceride levels but increased postprandial triglyceride levels. We show that ambient light intensity acutely affects human plasma glucose and triglyceride levels. Our findings warrant further research into the consequences of the metabolic effects of light for the diagnosis and prevention of hyperglycemia and dyslipidemia.
[Mh] Termos MeSH primário: Glicemia
Diabetes Mellitus Tipo 2/sangue
Luz
Triglicerídeos/sangue
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Dislipidemias/diagnóstico
Ingestão de Alimentos
Jejum/sangue
Seres Humanos
Hiperglicemia/diagnóstico
Metabolismo dos Lipídeos
Masculino
Meia-Idade
Período Pós-Prandial
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Triglycerides)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1177/0748730417693480


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[PMID]:29198188
[Au] Autor:Pimentel G; Burton KJ; Rosikiewicz M; Freiburghaus C; von Ah U; Münger LH; Pralong FP; Vionnet N; Greub G; Badertscher R; Vergères G
[Ad] Endereço:1Agroscope,Schwarzenburgstrasse 161,3003 Bern,Switzerland.
[Ti] Título:Blood lactose after dairy product intake in healthy men.
[So] Source:Br J Nutr;118(12):1070-1077, 2017 Dec.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The absence of a dedicated transport for disaccharides in the intestine implicates that the metabolic use of dietary lactose relies on its prior hydrolysis at the intestinal brush border. Consequently, lactose in blood or urine has mostly been associated with specific cases in which the gastrointestinal barrier is damaged. On the other hand, lactose appears in the blood of lactating women and has been detected in the blood and urine of healthy men, indicating that the presence of lactose in the circulation of healthy subjects is not incompatible with normal physiology. In this cross-over study we have characterised the postprandial kinetics of lactose, and its major constituent, galactose, in the serum of fourteen healthy men who consumed a unique dose of 800 g milk or yogurt. Genetic testing for lactase persistence and microbiota profiling of the subjects were also performed. Data revealed that lactose does appear in serum after dairy intake, although with delayed kinetics compared with galactose. Median serum concentrations of approximately 0·02 mmol/l lactose and approximately 0·2 mmol/l galactose were observed after the ingestion of milk and yogurt respectively. The serum concentrations of lactose were inversely correlated with the concentrations of galactose, and the variability observed between the subjects' responses could not be explained by the presence of the lactase persistence allele. Finally, lactose levels have been associated with the abundance of the Veillonella genus in faecal microbiota. The measurement of systemic lactose following dietary intake could provide information about lactose metabolism and nutrient transport processes under normal or pathological conditions.
[Mh] Termos MeSH primário: Dieta
Lactose/sangue
Leite
Iogurte
[Mh] Termos MeSH secundário: Adolescente
Adulto
Alelos
Animais
Estudos Cross-Over
Método Duplo-Cego
Fezes/microbiologia
Galactose/sangue
Microbioma Gastrointestinal
Seres Humanos
Intestinos/metabolismo
Intestinos/microbiologia
Masculino
Período Pós-Prandial
Veillonella/isolamento & purificação
Adulto Jovem
beta-Galactosidase/genética
beta-Galactosidase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
EC 3.2.1.23 (beta-Galactosidase); J2B2A4N98G (Lactose); X2RN3Q8DNE (Galactose)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517003245


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[PMID]:28747486
[Au] Autor:Chalvon-Demersay T; Even PC; Chaumontet C; Piedcoq J; Viollet B; Gaudichon C; Tomé D; Foretz M; Azzout-Marniche D
[Ad] Endereço:UMR Nutrition Physiology and Ingestive Behavior, AgroParisTech, INRA, Paris-Saclay University, Paris, France.
[Ti] Título:Modifying the Dietary Carbohydrate-to-Protein Ratio Alters the Postprandial Macronutrient Oxidation Pattern in Liver of AMPK-Deficient Mice.
[So] Source:J Nutr;147(9):1669-1676, 2017 09.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hepatic AMP-activated kinase (AMPK) activity is sensitive to the dietary carbohydrate-to-protein ratio. However, the role of AMPK in metabolic adaptations to variations in dietary macronutrients remains poorly understood. The objective of this study was to determine the role of hepatic AMPK in the adaptation of energy metabolism in response to modulation of the dietary carbohydrate-to-protein ratio. Male 7-wk-old wild-type (WT) and liver AMPK-deficient (knockout) mice were fed either a normal-protein and normal-carbohydrate diet (NP-NC; 14% protein, 76% carbohydrate on an energy basis), a low-protein and high-carbohydrate diet (LP-HC; 5% protein, 85% carbohydrate), or a high-protein and low-carbohydrate diet (HP-LC; 55% protein, 35% carbohydrate) for 3 wk. During this period, after an overnight fast, metabolic parameters were measured and indirect calorimetry was performed in mice during the first hours after refeeding a 1-g calibrated meal of their own diet in order to investigate lipid and carbohydrate metabolism. Knockout mice fed an LP-HC or HP-LC meal exhibited 24% and 8% lower amplitudes in meal-induced carbohydrate and lipid oxidation changes. By contrast, knockout mice fed an NP-NC meal displayed normal carbohydrate and lipid oxidation profiles. These mice exhibited a transient increase in hepatic triglycerides and a decrease in hepatic glycogen. These changes were associated with a 650% higher secretion of fibroblast growth factor 21 (FGF21) 2 h after refeeding. The consequences of hepatic AMPK deletion depend on the dietary carbohydrate-to-protein ratio. In mice fed the NP-NC diet, deletion of AMPK in the liver led to an adaptation of liver metabolism resulting in increased secretion of FGF21. These changes possibly compensated for the absence of hepatic AMPK, as these mice exhibited normal postprandial changes in carbohydrate and lipid oxidation. By contrast, in mice fed the LP-HC and HP-LC diets, the lack of adjustment in liver metabolism in knockout mice resulted in a metabolic inflexibility, leading to a reduced amplitude of meal-induced changes in carbohydrate and lipid oxidation.
[Mh] Termos MeSH primário: Proteínas Quinases Ativadas por AMP/metabolismo
Metabolismo dos Carboidratos
Carboidratos da Dieta/administração & dosagem
Proteínas na Dieta/administração & dosagem
Metabolismo dos Lipídeos
Fígado/efeitos dos fármacos
Período Pós-Prandial
[Mh] Termos MeSH secundário: Proteínas Quinases Ativadas por AMP/deficiência
Adaptação Fisiológica
Animais
Dieta
Dieta com Restrição de Carboidratos
Dieta com Restrição de Proteínas
Carboidratos da Dieta/metabolismo
Carboidratos da Dieta/farmacologia
Gorduras na Dieta/metabolismo
Proteínas na Dieta/metabolismo
Proteínas na Dieta/farmacologia
Metabolismo Energético/efeitos dos fármacos
Jejum
Fatores de Crescimento de Fibroblastos/metabolismo
Glicogênio/metabolismo
Fígado/metabolismo
Masculino
Refeições
Camundongos Knockout
Oxirredução
Triglicerídeos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Dietary Carbohydrates); 0 (Dietary Fats); 0 (Dietary Proteins); 0 (Triglycerides); 0 (fibroblast growth factor 22, mouse); 62031-54-3 (Fibroblast Growth Factors); 9005-79-2 (Glycogen); EC 2.7.11.31 (AMP-Activated Protein Kinases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.250803



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