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[PMID]:29200983
[Au] Autor:Roberts J; Zinchenko A; Suckling C; Smith L; Johnstone J; Henselmans M
[Ad] Endereço:Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, East Road, Cambridge, UK.
[Ti] Título:The short-term effect of high versus moderate protein intake on recovery after strength training in resistance-trained individuals.
[So] Source:J Int Soc Sports Nutr;14:44, 2017.
[Is] ISSN:1550-2783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Dietary protein intakes up to 2.9 g.kg .d and protein consumption before and after resistance training may enhance recovery, resulting in hypertrophy and strength gains. However, it remains unclear whether protein quantity or nutrient timing is central to positive adaptations. This study investigated the effect of total dietary protein content, whilst controlling for protein timing, on recovery in resistance trainees. Methods: Fourteen resistance-trained individuals underwent two 10-day isocaloric dietary regimes with a protein content of 1.8 g.kg .d (PRO ) or 2.9 g.kg .d (PRO ) in a randomised, counterbalanced, crossover design. On days 8-10 (T1-T3), participants undertook resistance exercise under controlled conditions, performing 3 sets of squat, bench press and bent-over rows at 80% 1 repetition maximum until volitional exhaustion. Additionally, participants consumed a 0.4 g.kg whey protein concentrate/isolate mix 30 min before and after exercise sessions to standardise protein timing specific to training. Recovery was assessed via daily repetition performance, muscle soreness, bioelectrical impedance phase angle, plasma creatine kinase (CK) and tumor necrosis factor-α (TNF-α). Results: No significant differences were reported between conditions for any of the performance repetition count variables ( > 0.05). However, within PRO only, squat performance total repetition count was significantly lower at T3 (19.7 ± 6.8) compared to T1 (23.0 ± 7.5; = 0.006). Pre and post-exercise CK concentrations significantly increased across test days ( ≤ 0.003), although no differences were reported between conditions. No differences for TNF-α or muscle soreness were reported between dietary conditions. Phase angle was significantly greater at T3 for PRO (8.26 ± 0.82°) compared with PRO (8.08 ± 0.80°; = 0.012). Conclusions: When energy intake and peri-exercise protein intake was controlled for, a short term PRO diet did not improve markers of muscle damage or soreness in comparison to a PRO approach following repeated days of intensive training. Whilst it is therefore likely that moderate protein intakes (1.8 g.kg .d ) may be sufficient for resistance-trained individuals, it is noteworthy that both lower body exercise performance and bioelectrical phase angle were maintained with PRO . Longer term interventions are warranted to determine whether PRO intakes are sufficient during prolonged training periods or when extensive exercise (e.g. training twice daily) is undertaken.
[Mh] Termos MeSH primário: Proteínas na Dieta/administração & dosagem
Proteínas na Dieta/farmacologia
Suplementos Nutricionais
Músculo Esquelético/efeitos dos fármacos
Músculo Esquelético/fisiologia
Treinamento de Resistência
Levantamento de Peso
[Mh] Termos MeSH secundário: Adulto
Estudos Cross-Over
Feminino
Seres Humanos
Masculino
Contração Muscular
Músculo Esquelético/metabolismo
Resistência Física
Fenômenos Fisiológicos da Nutrição Esportiva
Levantamento de Peso/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Dietary Proteins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1186/s12970-017-0201-z


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[PMID]:29291445
[Au] Autor:Bouhedja M; Peres B; Fhayli W; Ghandour Z; Boumendjel A; Faury G; Khelili S
[Ad] Endereço:Laboratoire de Phytochimie et de Pharmacologie, Département de Chimie, Faculté des Sciences Exactes et Informatique, Université Mohamed Seddik Ben Yahia Jijel, B.P. 98 Ouled Aissa, 18000 Jijel, Algeria; Université Grenoble-Alpes/CNRS, Département de Pharmacochimie Moléculaire UMR 5063, F-38041 Greno
[Ti] Título:Design, synthesis and biological evaluation of novel ring-opened cromakalim analogues with relaxant effects on vascular and respiratory smooth muscles and as stimulators of elastin synthesis.
[So] Source:Eur J Med Chem;144:774-796, 2018 Jan 20.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Two new series of ring-opened analogues of cromakalim bearing sulfonylurea moieties (series A: with N-unmethylated sulfonylureas, series B: with N-methylated sulfonylureas) were synthesized and tested as relaxants of vascular and respiratory smooth muscles (rat aorta and trachea, respectively). Ex vivo biological evaluations indicated that the most active compounds, belonging to series B, displayed a marked vasorelaxant activity on endothelium-intact aortic rings and the trachea. A majority of series B compounds exhibited a higher vasorelaxant activity (EC < 22 µM) than that of the reference compound diazoxide (EC = 24 µM). Interestingly, several tested compounds of series B also presented stronger relaxant effects on the trachea than the reference compound cromakalim (EC = 124 µM), in particular compounds B4, B7 and B16 (EC < 10 µM). By contrast, series A derivatives were poorly active on aortic rings (EC > 57 µM for all, and EC > 200 µM for a majority of them), but some of them showed an interesting relaxing effect on trachea (i.e. A15 and A33, EC = 30 µM). The most potent compounds of both series, i.e. A15, A33 and B16, tested on aortic rings in the presence of glibenclamide or 80 mM KCl, suggested that they acted as voltage-gated Ca channel blockers, like verapamil, instead of being ATP-potassium channel activators, as is cromakalim, the parent molecule. Further investigations on cultured vascular smooth muscle cells showed a strong stimulating effect on elastin synthesis, especially compound B16, which was more active at 20 µM than diazoxide, a reference ATP-sensitive potassium channel activator. Taken together, our results show that the N-methylation of the sulfonylurea moieties of ring-opened cromakalim analogues led to new compounds blocking calcium-gated channels, which had a major impact on the arterial and tracheal activities as well as selectivity.
[Mh] Termos MeSH primário: Cromakalim/farmacologia
Desenho de Drogas
Elastina/biossíntese
Músculo Liso/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Cromakalim/síntese química
Cromakalim/química
Relação Dose-Resposta a Droga
Feminino
Estrutura Molecular
Contração Muscular/efeitos dos fármacos
Ratos
Ratos Wistar
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0G4X367WA3 (Cromakalim); 9007-58-3 (Elastin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180102
[St] Status:MEDLINE


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[PMID]:28459157
[Au] Autor:Ozer EK; Goktas MT; Kilinc I; Toker A; Bariskaner H; Ugurluoglu C; Iskit AB
[Ad] Endereço:a Department of Pharmacology, Faculty of Medicine, Selcuk University, Konya, Turkey.
[Ti] Título:Infliximab alleviates the mortality, mesenteric hypoperfusion, aortic dysfunction, and multiple organ damage in septic rats.
[So] Source:Can J Physiol Pharmacol;95(7):866-872, 2017 Jul.
[Is] ISSN:1205-7541
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Tumor necrosis factor-alpha (TNF-α) is a pivotal mediator that triggers inflammatory process, oxidative stress, and multiple organ injury in sepsis. We investigated the effects of infliximab on survival, mesenteric artery blood flow (MBF), vascular reactivity, and oxidative and inflammatory injuries in cecal ligation and puncture (CLP)-induced sepsis. Wistar rats were divided into Sham, CLP, Sham+infliximab, and CLP+infliximab subgroups. Twenty-four hours before the operations, rats were injected intraperitoneally with infliximab (7 mg/kg) or vehicle (saline; 1 mL/kg). Twenty hours after the operations, MBF and phenylephrine responses of isolated aortic rings were measured. Tissue damages were examined biochemically and histopathologically. Furthermore, survival rates were monitored throughout 96 h. Infliximab improved survival, mesenteric perfusion, and aortic function after CLP. Increases of serum AST, ALT, LDH, BUN, Cr, and inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6) induced by CLP were blocked by infliximab. Infliximab prevented malondialdehyde elevations in septic liver, lung, spleen, and kidney tissues, as well as glutathione reductions in septic liver, spleen, and kidney tissues. Protective effects of infliximab on multiple organ damage were also observed histopathologically. Infliximab showed protective effects in sepsis due to its improvement effects on mesenteric perfusion, aortic function, and its anti-inflammatory and antioxidative effects.
[Mh] Termos MeSH primário: Aorta/efeitos dos fármacos
Circulação Sanguínea/efeitos dos fármacos
Infliximab/farmacologia
Mesentério/irrigação sanguínea
Insuficiência de Múltiplos Órgãos/complicações
Sepse/mortalidade
Sepse/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Aorta/fisiopatologia
Feminino
Interleucina-6/metabolismo
Contração Muscular/efeitos dos fármacos
Músculo Liso Vascular/efeitos dos fármacos
Músculo Liso Vascular/fisiopatologia
Ratos
Ratos Wistar
Sepse/complicações
Sepse/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-6); B72HH48FLU (Infliximab)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1139/cjpp-2016-0628


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[PMID]:29357379
[Au] Autor:Darwiche W; Gay-Quéheillard J; Delanaud S; El Khayat El Sabbouri H; Khachfe H; Joumaa W; Bach V; Ramadan W
[Ad] Endereço:PériTox, Périnatalité & Risques Toxiques, UMR-I 01 INERIS, Amiens, France.
[Ti] Título:Impact of chronic exposure to the pesticide chlorpyrifos on respiratory parameters and sleep apnea in juvenile and adult rats.
[So] Source:PLoS One;13(1):e0191237, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The widely used organophosphorus pesticide chlorpyrifos (CPF) is often detected in food. CPF inhibits acetylcholinesterase and can modify muscle contractility and respiratory patterns. We studied the effects of chronic exposure to CPF on respiratory parameters and diaphragm contractility in 21- and 60-days old rats. Pregnant rats were exposed to oral CPF (1 or 5 mg/ kg /day: CPF-1 or CPF-5 groups vs vehicle: controls) from gestation onset up to weaning of the pups that were individually gavaged (CPF or vehicle) thereafter. Two developmental time points were studied: weaning (day 21) and adulthood (day 60). Whole-body plethysmography was used to score breathing patterns and apnea index during sleep. Then, diaphragm strips were dissected for the assessment of contractility and acetylcholinesterase activity. Results showed that the sleep apnea index was higher in CPF-exposed rats than in controls. In adult rats, the expiratory time and tidal volume were higher in CPF-exposed animals than in controls. At both ages, the diaphragm's amplitude of contraction and fatigability index were higher in the CPF-5 group, due to lower acetylcholinesterase activity. We conclude that chronic exposure to CPF is associated with higher sleep apnea index and diaphragm contractility, and modifies respiratory patterns in sleeping juvenile and adult rats.
[Mh] Termos MeSH primário: Clorpirifos/toxicidade
Praguicidas/toxicidade
Respiração/efeitos dos fármacos
Síndromes da Apneia do Sono/induzido quimicamente
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Animais
Clorpirifos/administração & dosagem
Inibidores da Colinesterase/administração & dosagem
Inibidores da Colinesterase/toxicidade
Diafragma/efeitos dos fármacos
Diafragma/fisiopatologia
Feminino
Masculino
Contração Muscular/efeitos dos fármacos
Pletismografia Total
Gravidez
Efeitos Tardios da Exposição Pré-Natal/fisiopatologia
Ratos
Síndromes da Apneia do Sono/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cholinesterase Inhibitors); 0 (Pesticides); EC 3.1.1.7 (Acetylcholinesterase); JCS58I644W (Chlorpyrifos)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191237


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[PMID]:29297640
[Au] Autor:Kolesnikova LI; Madaeva IM; Semenova NV; Osipova EV; Darenskaya MA
[Ti] Título:Serum Myokines Levels in Patients with Endogenous Cushing Syndrome and Acromegaly: Cross-Sectional Case−Control Study.
[So] Source:Vestn Ross Akad Med Nauk;71(3):240-7, 2016.
[Is] ISSN:0869-6047
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:Background: Myokines are produced and released by muscle cells in response to muscular contractions. Endogenous Cushing syndrome (CS) and acromegaly cause significant changes in muscle tissue leading to atrophy or hypertrophy. However, there is no data whether these endocrine abnormalities influence myokine secretion. Aims: To evaluate serum levels of myostatin, interleukin-6 (IL6) and irisin in patients with CS and acromegaly. Materials and Methods: Fasting serum samples were taken and stored in aliquot at ≤-20°C from consecutive subjects with clinically evident and biochemically confirmed active CS, acromegaly and healthy volunteers matched by age, sex and body mass index (BMI). Commercially available kits were used to assay serum myokine levels. Grip strength was measured by a dynamometer. Insulin-like growth factor-1 (IGF1) was measured by immunochemiluminescence assay (Liaison), twenty-four hours urine free cortisol (24hUFC) ­ by immunochemiluminescence assay (Vitros ECi), salivary free cortisol ­ by electrochemiluminescence assay (Cobas). One-way ANOVA was utilized to assess the difference between groups. Results: We enrolled 88 subjects: 30 patients suffered from CS (group 1), 28 ­ acromegaly (2) and 30 matched healthy controls (3) with no difference among the groups in sex, age and BMI (p=0.492, 0.062 and 0.174 respectively). Mean 24hUFC in subjects with CS and mean IGF1 in subjects with acromegaly were significantly higher as compared to other groups (p<0.001). Right-hand grip strength was lower in patients with CS as compared to both patients with acromegaly and healthy subjects (p=0.04). However, among these young adults we did not find statistically significant differences in measured myokines levels: irisin ­ p=0.15; IL6 ­ p=0.34; myostatin ­ p=0.50. There was a significant correlation between myostatin and irisin in the whole group of people and in every separately analyzed subset of patients (p<0.001), but no correlation was found between any measured myokines and 24hUFC or IGF1. Conclusions: Hypercortisolism or supraphysiological IGF1 levels do not significantly influence serum levels of myostatin, IL6 and irisin in young adults.
[Mh] Termos MeSH primário: Acromegalia
Fibronectinas/sangue
Fator de Crescimento Insulin-Like I
Interleucina-6/sangue
Músculo Esquelético
Miostatina/sangue
[Mh] Termos MeSH secundário: Acromegalia/etiologia
Acromegalia/metabolismo
Acromegalia/fisiopatologia
Adulto
Síndrome de Cushing/complicações
Feminino
Seres Humanos
Fator de Crescimento Insulin-Like I/análise
Fator de Crescimento Insulin-Like I/metabolismo
Masculino
Contração Muscular/fisiologia
Músculo Esquelético/metabolismo
Músculo Esquelético/fisiopatologia
Estatística como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (FNDC5 protein, human); 0 (Fibronectins); 0 (Interleukin-6); 0 (Myostatin); 67763-96-6 (Insulin-Like Growth Factor I)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.15690/vramn659


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[PMID]:28456776
[Au] Autor:Verbickas V; Baranauskiene N; Eimantas N; Kamandulis S; Rutkauskas S; Satkunskiene D; Sadauskas S; Brazaitis M; Skurvydas A
[Ad] Endereço:Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, Lithuania. v.verbickas@gmail.com.
[Ti] Título:Effect of sprint cycling and stretch-shortening cycle exercises on the neuromuscular, immune and stress indicators in young men.
[So] Source:J Physiol Pharmacol;68(1):125-132, 2017 02.
[Is] ISSN:1899-1505
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Selection of optimal physical load is essential for desired adaptation including health benefits. We hypothesized that neuromuscular, immune and stress indicators will be higher after energy demanding sprint interval exercise (SIE) than to mechanically demanding stretch-shortening cycle exercise (SSE). The main aim of this study was to assess and compare the kinetics of blood brain-derived neurotrophic factor (BDNF), norepinephrine (NE) and cortisol (as stress indicators) and proinflammatory (IL-6) and anti-inflammatory (IL-10) cytokines within 24 hours after metabolically demanding SIE and after muscle damage inducing SSE. Twenty healthy physically active young men randomly assigned to two equal groups to complete 12 bouts of 5 s stationary cycling sprints every 3 min (SIE) or 200 drop-jumps with 30 s interval between each jump (SSE), respectively. Quadriceps muscle maximal voluntary contraction torque and voluntary activation and soreness were measured and blood samples collected before and 2 min, 1 hour, 12 hours and 24 hours after the SIE and SSE. The BDNF, cortisol, IL-6 and NE levels increased more at 2 min after SIE than SSE (P < 0.05); however, the IL-10 level did not differ between SIE and SSE. BDNF and cortisol levels were decreased at 24 h after both SIE and especially after SSE. The higher was the initial BDNF level, the greater was its decrease at 24 h after both type of exercise. Before exercise BDNF level correlated closely with the change in central fatigue (decrease in voluntary activation) after both SIE and SSE. We thus conclude that both metabolically demanding SIE and muscle damage inflicting SSE induced long-lasting decrease in circulating BDNF which may not promote brain health. The level of circulating BDNF, but not cortisol, IL-6, IL-10 or NE, was associated with changes in central motor fatigue.
[Mh] Termos MeSH primário: Ciclismo/fisiologia
Exercício/fisiologia
[Mh] Termos MeSH secundário: Adulto
Fator Neurotrófico Derivado do Encéfalo/sangue
Creatina Quinase/sangue
Seres Humanos
Hidrocortisona/sangue
Interleucina-10/sangue
Interleucina-6/sangue
Masculino
Contração Muscular
Fadiga Muscular/imunologia
Fadiga Muscular/fisiologia
Norepinefrina/sangue
Músculo Quadríceps/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Brain-Derived Neurotrophic Factor); 0 (IL10 protein, human); 0 (IL6 protein, human); 0 (Interleukin-6); 0 (brain-derived neurotrophic factor, human); 130068-27-8 (Interleukin-10); EC 2.7.3.2 (Creatine Kinase); WI4X0X7BPJ (Hydrocortisone); X4W3ENH1CV (Norepinephrine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:29284062
[Au] Autor:Fenwick AJ; Wood AM; Tanner BCW
[Ad] Endereço:Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington, United States of America.
[Ti] Título:Effects of cross-bridge compliance on the force-velocity relationship and muscle power output.
[So] Source:PLoS One;12(12):e0190335, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Muscles produce force and power by utilizing chemical energy through ATP hydrolysis. During concentric contractions (shortening), muscles generate less force compared to isometric contractions, but consume greater amounts of energy as shortening velocity increases. Conversely, more force is generated and less energy is consumed during eccentric muscle contractions (lengthening). This relationship between force, energy use, and the velocity of contraction has important implications for understanding muscle efficiency, but the molecular mechanisms underlying this behavior remain poorly understood. Here we used spatially-explicit, multi-filament models of Ca2+-regulated force production within a half-sarcomere to simulate how force production, energy utilization, and the number of bound cross-bridges are affected by dynamic changes in sarcomere length. These computational simulations show that cross-bridge binding increased during slow-velocity concentric and eccentric contractions, compared to isometric contractions. Over the full ranges of velocities that we simulated, cross-bridge cycling and energy utilization (i.e. ATPase rates) increased during shortening, and decreased during lengthening. These findings are consistent with the Fenn effect, but arise from a complicated relationship between velocity-dependent cross-bridge recruitment and cross-bridge cycling kinetics. We also investigated how force production, power output, and energy utilization varied with cross-bridge and myofilament compliance, which is impossible to address under typical experimental conditions. These important simulations show that increasing cross-bridge compliance resulted in greater cross-bridge binding and ATPase activity, but less force was generated per cross-bridge and throughout the sarcomere. These data indicate that the efficiency of force production decreases in a velocity-dependent manner, and that this behavior is sensitive to cross-bridge compliance. In contrast, significant effects of myofilament compliance on force production were only observed during isometric contractions, suggesting that changes in myofilament compliance may not influence power output during non-isometric contractions as greatly as changes in cross-bridge compliance. These findings advance our understanding of how cross-bridge and myofilament properties underlie velocity-dependent changes in contractile efficiency during muscle movement.
[Mh] Termos MeSH primário: Músculo Esquelético/fisiologia
[Mh] Termos MeSH secundário: Trifosfato de Adenosina/metabolismo
Cálcio/metabolismo
Seres Humanos
Contração Muscular
Músculo Esquelético/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
8L70Q75FXE (Adenosine Triphosphate); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190335


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[PMID]:29419681
[Au] Autor:Park GY; Kwon DR; Kwon DG
[Ad] Endereço:Department of Rehabilitation Medicine, Catholic University of Daegu School of Medicine, Daegu, South Korea.
[Ti] Título:Shear wave sonoelastography in infants with congenital muscular torticollis.
[So] Source:Medicine (Baltimore);97(6):e9818, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Congenital muscular torticollis (CMT) is characterized by shortening or excessive contraction of the sternocleidomastoid muscle (SCM). The main purpose of this study was to evaluate the feasibility of quantifying SCM stiffness using acoustic radiation force impulse (ARFI) sonoelastography in infants with CMT. Twenty infants with an SCM thickness greater than 10 mm with or without involvement of the entire SCM length (limitation of neck rotation passive range of motion [PROM]: group 1S >30°, group 1M = 15°-30°) and 12 infants with an SCM thickness smaller than 10 mm with or without involvement of any part of SCM (group 2) were included. The SCM thickness was measured using real time B-mode ultrasound, and the local SCM shear wave velocity (SWV) and subcutaneous fat layer using ARFI sonoelastography. The neck rotation PROM was significantly greater in group 1S (36.5°â€Š±â€Š5.3°) than in group 1M (18.8°â€Š±â€Š4.9°; P < .01); the SWV of the SCM in the affected side (2.96 ±â€Š0.99 m/s) was significantly higher than that in the unaffected side (1.50 ±â€Š0.30 m/s; P < .01) in group 1. The SWV of the SCM was significantly higher in group 1S than in group 1M. There was significant correlation between the degree of PROM deficit of neck rotation and the SWV of the affected SCM (r = .75; P < .01) in all infants. This study revealed a difference in the SWV of the affected SCM in relationship to the limitation of neck rotation PROM in infants with CMT, if there was no difference in SCM thickness among infants.
[Mh] Termos MeSH primário: Técnicas de Imagem por Elasticidade/métodos
Músculos do Pescoço
Torcicolo/congênito
[Mh] Termos MeSH secundário: Estudos Transversais
Elasticidade/fisiologia
Feminino
Seres Humanos
Lactente
Masculino
Contração Muscular/fisiologia
Músculos do Pescoço/diagnóstico por imagem
Músculos do Pescoço/fisiopatologia
Amplitude de Movimento Articular
República da Coreia
Estatística como Assunto
Torcicolo/diagnóstico
Torcicolo/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009818


  9 / 90959 MEDLINE  
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[PMID]:29320528
[Au] Autor:Peterson T; Müller GB
[Ad] Endereço:Department of Theoretical Biology, University of Vienna, Wien, Austria.
[Ti] Título:Developmental finite element analysis of cichlid pharyngeal jaws: Quantifying the generation of a key innovation.
[So] Source:PLoS One;13(1):e0189985, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Advances in imaging and modeling facilitate the calculation of biomechanical forces in biological specimens. These factors play a significant role during ontogenetic development of cichlid pharyngeal jaws, a key innovation responsible for one of the most prolific species diversifications in recent times. MicroCT imaging of radiopaque-stained vertebrate embryos were used to accurately capture the spatial relationships of the pharyngeal jaw apparatus in two cichlid species (Haplochromis elegans and Amatitlania nigrofasciata) for the purpose of creating a time series of developmental stages using finite element models, which can be used to assess the effects of biomechanical forces present in a system at multiple points of its ontogeny. Changes in muscle vector orientations, bite forces, force on the neurocranium where cartilage originates, and stress on upper pharyngeal jaws are analyzed in a comparative context. In addition, microCT scanning revealed the presence of previously unreported cement glands in A. nigrofasciata. The data obtained provide an underrepresented dimension of information on physical forces present in developmental processes and assist in interpreting the role of developmental dynamics in evolution.
[Mh] Termos MeSH primário: Estruturas Animais/anatomia & histologia
Ciclídeos/anatomia & histologia
Estresse Mecânico
[Mh] Termos MeSH secundário: Estruturas Animais/embriologia
Estruturas Animais/crescimento & desenvolvimento
Animais
Evolução Biológica
Região Branquial
Ciclídeos/embriologia
Ciclídeos/crescimento & desenvolvimento
Simulação por Computador
Ingestão de Alimentos/fisiologia
Análise de Elementos Finitos
Mastigação/fisiologia
Modelos Biológicos
Morfogênese
Contração Muscular
Músculos Faríngeos/embriologia
Músculos Faríngeos/crescimento & desenvolvimento
Músculos Faríngeos/fisiologia
Crânio/embriologia
Crânio/crescimento & desenvolvimento
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189985


  10 / 90959 MEDLINE  
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[PMID]:29253568
[Au] Autor:Murata K; Morino K; Ida S; Ohashi N; Lemecha M; Park SY; Ishikado A; Kume S; Choi CS; Sekine O; Ugi S; Maegawa H
[Ad] Endereço:Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga, 520-2192, Japan.
[Ti] Título:Lack of O-GlcNAcylation enhances exercise-dependent glucose utilization potentially through AMP-activated protein kinase activation in skeletal muscle.
[So] Source:Biochem Biophys Res Commun;495(2):2098-2104, 2018 01 08.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:O-GlcNAcylation is a post-translational modification that is characterized by the addition of N-acetylglucosamine (GlcNAc) to proteins by O-GlcNAc transferase (Ogt). The degree of O-GlcNAcylation is thought to be associated with glucotoxicity and diabetic complications, because GlcNAc is produced by a branch of the glycolytic pathway. However, its role in skeletal muscle has not been fully elucidated. In this study, we created skeletal muscle-specific Ogt knockout (Ogt-MKO) mice and analyzed their glucose metabolism. During an intraperitoneal glucose tolerance test, blood glucose was slightly lower in Ogt-MKO mice than in control Ogt-flox mice. High fat diet-induced obesity and insulin resistance were reversed in Ogt-MKO mice. In addition, 12-month-old Ogt-MKO mice had lower adipose and body mass. A single bout of exercise significantly reduced blood glucose in Ogt-MKO mice, probably because of higher AMP-activated protein kinase α (AMPKα) protein expression. Furthermore, intraperitoneal injection of 5-aminoimidazole-4-carboxamide ribonucleotide, an AMPK activator, resulted in a more marked decrease in blood glucose levels in Ogt-MKO mice than in controls. Finally, Ogt knockdown by siRNA in C2C12 myotubes significantly increased protein expression of AMPKα, glucose uptake and oxidation. In conclusion, loss of O-GlcNAcylation facilitates glucose utilization in skeletal muscle, potentially through AMPK activation. The inhibition of O-GlcNAcylation in skeletal muscle may have an anti-diabetic effect, through an enhancement of glucose utilization during exercise.
[Mh] Termos MeSH primário: Proteínas Quinases Ativadas por AMP/metabolismo
Glucose/metabolismo
Contração Muscular/fisiologia
Músculo Esquelético/fisiologia
N-Acetilglucosaminiltransferases/metabolismo
Esforço Físico/fisiologia
[Mh] Termos MeSH secundário: Acilação/fisiologia
Animais
Glicemia/metabolismo
Ativação Enzimática/fisiologia
Regulação Enzimológica da Expressão Gênica/fisiologia
Masculino
Camundongos
Camundongos Knockout
Condicionamento Físico Animal/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); EC 2.4.1.- (N-Acetylglucosaminyltransferases); EC 2.4.1.- (O-GlcNAc transferase); EC 2.7.11.31 (AMP-Activated Protein Kinases); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE



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