Base de dados : MEDLINE
Pesquisa : G11.561 [Categoria DeCS]
Referências encontradas : 6125 [refinar]
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[PMID]:29307030
[Au] Autor:O'Donnell S
[Ad] Endereço:Department of Biodiversity Earth and Environmental Science, Drexel University, Philadelphia, PA, 19104, USA. so356@drexel.edu.
[Ti] Título:The neurobiology of climate change.
[So] Source:Naturwissenschaften;105(1-2):11, 2018 Jan 06.
[Is] ISSN:1432-1904
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Directional climate change (global warming) is causing rapid alterations in animals' environments. Because the nervous system is at the forefront of animals' interactions with the environment, the neurobiological implications of climate change are central to understanding how individuals, and ultimately populations, will respond to global warming. Evidence is accumulating for individual level, mechanistic effects of climate change on nervous system development and performance. Climate change can also alter sensory stimuli, changing the effectiveness of sensory and cognitive systems for achieving biological fitness. At the population level, natural selection forces stemming from directional climate change may drive rapid evolutionary change in nervous system structure and function.
[Mh] Termos MeSH primário: Evolução Biológica
Mudança Climática
Fenômenos Fisiológicos do Sistema Nervoso
[Mh] Termos MeSH secundário: Adaptação Fisiológica
Animais
Seleção Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180108
[St] Status:MEDLINE
[do] DOI:10.1007/s00114-017-1538-5


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[PMID]:29184204
[Au] Autor:Winder AT; Echagarruga C; Zhang Q; Drew PJ
[Ad] Endereço:Center for Neural Engineering, Pennsylvania State University, University Park, PA, USA.
[Ti] Título:Weak correlations between hemodynamic signals and ongoing neural activity during the resting state.
[So] Source:Nat Neurosci;20(12):1761-1769, 2017 Dec.
[Is] ISSN:1546-1726
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Spontaneous fluctuations in hemodynamic signals in the absence of a task or overt stimulation are used to infer neural activity. We tested this coupling by simultaneously measuring neural activity and changes in cerebral blood volume (CBV) in the somatosensory cortex of awake, head-fixed mice during periods of true rest and during whisker stimulation and volitional whisking. We found that neurovascular coupling was similar across states and that large, spontaneous CBV changes in the absence of sensory input were driven by volitional whisker and body movements. Hemodynamic signals during periods of rest were weakly correlated with neural activity. Spontaneous fluctuations in CBV and vessel diameter persisted when local neural spiking and glutamatergic input were blocked, as well as during blockade of noradrenergic receptors, suggesting a non-neuronal origin for spontaneous CBV fluctuations. Spontaneous hemodynamic signals reflect a combination of behavior, local neural activity, and putatively non-neural processes.
[Mh] Termos MeSH primário: Hemodinâmica/fisiologia
Descanso/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/fisiologia
Volume Sanguíneo
Circulação Cerebrovascular/fisiologia
Nervo Facial/fisiologia
Imagem por Ressonância Magnética
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Movimento/fisiologia
Fenômenos Fisiológicos do Sistema Nervoso
Estimulação Luminosa
Córtex Somatossensorial/irrigação sanguínea
Vibrissas/inervação
Vibrissas/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1038/s41593-017-0007-y


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[PMID]:28462674
[Au] Autor:Rehan Youssef A; Gumaa M
[Ad] Endereço:a Faculty of Physical Therapy , Cairo University , Giza , Egypt.
[Ti] Título:Validity and reliability of smartphone applications for clinical assessment of the neuromusculoskeletal system.
[So] Source:Expert Rev Med Devices;14(6):481-493, 2017 Jun.
[Is] ISSN:1745-2422
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Clinicians increasingly use smartphone medical applications. There is no evidence to support the validity and reliability of applications used to assess the neuromusculoskeletal system. The aim of this study was to systematically review the quality of studies as well as the validity and reliability of using a smartphone as a clinical assessment tool for the neuromusculoskeletal system. Areas covered: PubMed, CINAHL and Embase were searched. A manual search was also conducted. Additionally, forward snowballing of relevant articles was performed in Scopus and Web of Science. Two reviewers independently selected the articles, extracted the data using a standardized form and assessed the articles quality based on a scoring system Expert commentary: Thirty-four articles were found eligible and were categorized into four groups: Range of Motion (ROM), posture and deformity, tremors and reflexes, and gait and mobility. Only the ROM category supported the validity and reliability of using smartphone applications as assessment tools. Regarding quality assessment scores, the articles in ROM and posture and deformity categories ranged from poor to good quality, whereas those in the tremors and reflexes and gait and mobility categories had poor quality.
[Mh] Termos MeSH primário: Aplicativos Móveis
Fenômenos Fisiológicos Musculoesqueléticos
Fenômenos Fisiológicos do Sistema Nervoso
Smartphone
[Mh] Termos MeSH secundário: Marcha/fisiologia
Seres Humanos
Postura/fisiologia
Amplitude de Movimento Articular/fisiologia
Reflexo/fisiologia
Reprodutibilidade dos Testes
Tremor/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1080/17434440.2017.1325319


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[PMID]:29095816
[Au] Autor:Teng X; Tian X; Rowland J; Poeppel D
[Ad] Endereço:Max-Planck-Institute, Frankfurt, Germany.
[Ti] Título:Concurrent temporal channels for auditory processing: Oscillatory neural entrainment reveals segregation of function at different scales.
[So] Source:PLoS Biol;15(11):e2000812, 2017 Nov.
[Is] ISSN:1545-7885
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Natural sounds convey perceptually relevant information over multiple timescales, and the necessary extraction of multi-timescale information requires the auditory system to work over distinct ranges. The simplest hypothesis suggests that temporal modulations are encoded in an equivalent manner within a reasonable intermediate range. We show that the human auditory system selectively and preferentially tracks acoustic dynamics concurrently at 2 timescales corresponding to the neurophysiological theta band (4-7 Hz) and gamma band ranges (31-45 Hz) but, contrary to expectation, not at the timescale corresponding to alpha (8-12 Hz), which has also been found to be related to auditory perception. Listeners heard synthetic acoustic stimuli with temporally modulated structures at 3 timescales (approximately 190-, approximately 100-, and approximately 30-ms modulation periods) and identified the stimuli while undergoing magnetoencephalography recording. There was strong intertrial phase coherence in the theta band for stimuli of all modulation rates and in the gamma band for stimuli with corresponding modulation rates. The alpha band did not respond in a similar manner. Classification analyses also revealed that oscillatory phase reliably tracked temporal dynamics but not equivalently across rates. Finally, mutual information analyses quantifying the relation between phase and cochlear-scaled correlations also showed preferential processing in 2 distinct regimes, with the alpha range again yielding different patterns. The results support the hypothesis that the human auditory system employs (at least) a 2-timescale processing mode, in which lower and higher perceptual sampling scales are segregated by an intermediate temporal regime in the alpha band that likely reflects different underlying computations.
[Mh] Termos MeSH primário: Estimulação Acústica
Percepção Auditiva/fisiologia
Fenômenos Fisiológicos do Sistema Nervoso
[Mh] Termos MeSH secundário: Comportamento
Biomarcadores/metabolismo
Eletroencefalografia
Potenciais Evocados Auditivos/fisiologia
Feminino
Ritmo Gama/fisiologia
Seres Humanos
Masculino
Ritmo Teta/fisiologia
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171119
[Lr] Data última revisão:
171119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pbio.2000812


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[PMID]:29028836
[Au] Autor:Maqueda M; Roca E; Brotons D; Soria JM; Perera A
[Ad] Endereço:Department of ESAII, Center for Biomedical Engineering Research, Universitat Politècnica de Catalunya, Barcelona, Catalonia, Spain.
[Ti] Título:Affected pathways and transcriptional regulators in gene expression response to an ultra-marathon trail: Global and independent activity approaches.
[So] Source:PLoS One;12(10):e0180322, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Gene expression (GE) analyses on blood samples from marathon and half-marathon runners have reported significant impacts on the immune and inflammatory systems. An ultra-marathon trail (UMT) represents a greater effort due to its more testing conditions. For the first time, we report the genome-wide GE profiling in a group of 16 runners participating in an 82 km UMT competition. We quantified their differential GE profile before and after the race using HuGene2.0st microarrays (Affymetrix Inc., California, US). The results obtained were decomposed by means of an independent component analysis (ICA) targeting independent expression modes. We observed significant differences in the expression levels of 5,084 protein coding genes resulting in an overrepresentation of 14% of the human biological pathways from the Kyoto Encyclopedia of Genes and Genomes database. These were mainly clustered on terms related with protein synthesis repression, altered immune system and infectious diseases related mechanisms. In a second analysis, 27 out of the 196 transcriptional regulators (TRs) included in the Open Regulatory Annotation database were overrepresented. Among these TRs, we identified transcription factors from the hypoxia-inducible factors (HIF) family EPAS1 (p< 0.01) and HIF1A (p<0.001), and others jointly described in the gluconeogenesis program such as HNF4 (p< 0.001), EGR1 (p<0.001), CEBPA (p< 0.001) and a highly specific TR, YY1 (p<0.01). The five independent components, obtained from ICA, further revealed a down-regulation of 10 genes distributed in the complex I, III and V from the electron transport chain. This mitochondrial activity reduction is compatible with HIF-1 system activation. The vascular endothelial growth factor (VEGF) pathway, known to be regulated by HIF, also emerged (p<0.05). Additionally, and related to the brain rewarding circuit, the endocannabinoid signalling pathway was overrepresented (p<0.05).
[Mh] Termos MeSH primário: Perfilação da Expressão Gênica
Corrida/fisiologia
Transcrição Genética
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/metabolismo
Hipóxia Celular/genética
Linhagem da Célula/genética
Proliferação Celular/genética
Complexo de Proteínas da Cadeia de Transporte de Elétrons/metabolismo
Feminino
Genômica
Gluconeogênese/genética
Hematopoese/genética
Seres Humanos
Masculino
Fenômenos Fisiológicos do Sistema Nervoso/genética
Análise de Componente Principal
Transdução de Sinais/genética
Células Th1/metabolismo
Células Th2/metabolismo
Fatores de Transcrição/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Electron Transport Chain Complex Proteins); 0 (Transcription Factors)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171014
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180322


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[PMID]:29024648
[Au] Autor:Jones A; Reijmers LG
[Ad] Endereço:Department of Neuroscience, School of Medicine, Tufts University, Boston, MA 02111, USA; Graduate Program in Neuroscience, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, USA.
[Ti] Título:Mapping Brain Activity onto Molecularly Defined Cells.
[So] Source:Neuron;96(2):248-249, 2017 Oct 11.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The brain processes information and generates behavior by employing a wide array of different cell types. In this issue of Neuron, Wu et al. (2017) report a novel method that enables the efficient identification of molecularly defined cells that participate in a specific brain function.
[Mh] Termos MeSH primário: Mapeamento Encefálico
Neurônios
[Mh] Termos MeSH secundário: Encéfalo
Seres Humanos
Fenômenos Fisiológicos do Sistema Nervoso
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE


  7 / 6125 MEDLINE  
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[PMID]:28708995
[Au] Autor:Sousa AMM; Meyer KA; Santpere G; Gulden FO; Sestan N
[Ad] Endereço:Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
[Ti] Título:Evolution of the Human Nervous System Function, Structure, and Development.
[So] Source:Cell;170(2):226-247, 2017 Jul 13.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The nervous system-in particular, the brain and its cognitive abilities-is among humans' most distinctive and impressive attributes. How the nervous system has changed in the human lineage and how it differs from that of closely related primates is not well understood. Here, we consider recent comparative analyses of extant species that are uncovering new evidence for evolutionary changes in the size and the number of neurons in the human nervous system, as well as the cellular and molecular reorganization of its neural circuits. We also discuss the developmental mechanisms and underlying genetic and molecular changes that generate these structural and functional differences. As relevant new information and tools materialize at an unprecedented pace, the field is now ripe for systematic and functionally relevant studies of the development and evolution of human nervous system specializations.
[Mh] Termos MeSH primário: Evolução Biológica
Encéfalo/anatomia & histologia
Encéfalo/fisiologia
Sistema Nervoso/anatomia & histologia
Sistema Nervoso/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Encéfalo/citologia
Regulação da Expressão Gênica
Linguagem
Mutação
Proteínas do Tecido Nervoso/genética
Sistema Nervoso/citologia
Fenômenos Fisiológicos do Sistema Nervoso
Primatas/genética
Primatas/fisiologia
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Nerve Tissue Proteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE


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[PMID]:28486269
[Au] Autor:Vlisides PE; Bel-Bahar T; Lee U; Li D; Kim H; Janke E; Tarnal V; Pichurko AB; McKinney AM; Kunkler BS; Picton P; Mashour GA
[Ad] Endereço:From the Department of Anesthesiology (P.E.V., T.B.-B., U.L., D.L., H.K., E.J., V.T., A.M.M., B.S.K., P.P., G.A.M.), Center for Consciousness Science (P.E.V., T.B.-B., U.L., D.L., H.K., G.A.M.), and Neuroscience Graduate Program (G.A.M.), University of Michigan Medical School, Ann Arbor, Michigan; and the Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois (A.B.P.).
[Ti] Título:Neurophysiologic Correlates of Ketamine Sedation and Anesthesia: A High-density Electroencephalography Study in Healthy Volunteers.
[So] Source:Anesthesiology;127(1):58-69, 2017 Jul.
[Is] ISSN:1528-1175
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Previous studies have demonstrated inconsistent neurophysiologic effects of ketamine, although discrepant findings might relate to differences in doses studied, brain regions analyzed, coadministration of other anesthetic medications, and resolution of the electroencephalograph. The objective of this study was to characterize the dose-dependent effects of ketamine on cortical oscillations and functional connectivity. METHODS: Ten healthy human volunteers were recruited for study participation. The data were recorded using a 128-channel electroencephalograph during baseline consciousness, subanesthetic dosing (0.5 mg/kg over 40 min), anesthetic dosing (1.5 mg/kg bolus), and recovery. No other sedative or anesthetic medications were administered. Spectrograms, topomaps, and functional connectivity (weighted and directed phase lag index) were computed and analyzed. RESULTS: Frontal theta bandwidth power increased most dramatically during ketamine anesthesia (mean power ± SD, 4.25 ± 1.90 dB) compared to the baseline (0.64 ± 0.28 dB), subanesthetic (0.60 ± 0.30 dB), and recovery (0.68 ± 0.41 dB) states; P < 0.001. Gamma power also increased during ketamine anesthesia. Weighted phase lag index demonstrated theta phase locking within anterior regions (0.2349 ± 0.1170, P < 0.001) and between anterior and posterior regions (0.2159 ± 0.1538, P < 0.01) during ketamine anesthesia. Alpha power gradually decreased with subanesthetic ketamine, and anterior-to-posterior directed connectivity was maximally reduced (0.0282 ± 0.0772) during ketamine anesthesia compared to all other states (P < 0.05). CONCLUSIONS: Ketamine anesthesia correlates most clearly with distinct changes in the theta bandwidth, including increased power and functional connectivity. Anterior-to-posterior connectivity in the alpha bandwidth becomes maximally depressed with anesthetic ketamine administration, suggesting a dose-dependent effect.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Encéfalo/efeitos dos fármacos
Eletroencefalografia/efeitos dos fármacos
Ketamina/farmacologia
Fenômenos Fisiológicos do Sistema Nervoso/efeitos dos fármacos
[Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga
Seres Humanos
Valores de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 690G0D6V8H (Ketamine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.1097/ALN.0000000000001671


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[PMID]:28351482
[Au] Autor:Novopashin MA; Shmid AV; Berezin AA
[Ad] Endereço:EC-leasing Moscow, Russia.
[Ti] Título:Fermi-Pasta-Ulam auto recurrence in the description of the electrical activity of the heart.
[So] Source:Med Hypotheses;101:12-16, 2017 Apr.
[Is] ISSN:1532-2777
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The authors proposed and mathematically described model of a new type of the Fermi-Pasta-Ulam recurrence (the FPU auto recurrence) and hypothesized an adequate description of the heart's electrical dynamics within the observed phenomenon. The dynamics of the FPU auto recurrence making appropriate electrical dynamics of the normal functioning of the heart in the form of an electrocardiogram (ECG) was obtained by a computer model study. The model solutions in the form of the FPU auto recurrence - ECG Fourier spectrum were evaluated for resistance to external disturbances in the form of random effects, as well as periodic perturbation at a frequency close to the heart beating rate of about 1Hz. In addition, in order to simulate the dynamics of myocardial infarction model, studied the effect of the surface area of the myocardium on the stability and shape of the auto recurrence - ECG spectrum. It has been found that the intense external disturbing periodic impacts at a frequency of about 1Hz lead to a sharp disturbance spectrum shape FPU auto recurrence - ECG structure. In addition, the decrease in the surface of the myocardium by 50% in the model led to the destruction of structures of the auto recurrence - ECG, which corresponds to the state of atrial myocardium. Research models have revealed a hypothetical basis of coronary heart disease in the form of increasing the energy of high-frequency harmonics spectrum of the auto recurrence by reducing the energy of low-frequency harmonic spectrum of the auto recurrence, which ultimately leads to a sharp decrease in myocardial contractility. In order to test the hypothesis has been studied more than 20,000 ECGs both healthy people and patients with cardiovascular disease. As a result of these studies, it was found that the dynamics of the electrical activity of normal functioning of the heart can be interpreted by the display of the detected by authors the FPU auto recurrence, and coronary heart disease is a violation of the energy ratio between the low and high frequency harmonics of the FPU auto recurrence Fourier spectrum equal to the ECG spectrum. Thus, the hypothesis has been confirmed.
[Mh] Termos MeSH primário: Doença da Artéria Coronariana/fisiopatologia
Eletrocardiografia
Miocárdio
[Mh] Termos MeSH secundário: Simulação por Computador
Doença da Artéria Coronariana/diagnóstico por imagem
Análise de Fourier
Coração
Seres Humanos
Cinética
Modelos Teóricos
Miocárdio/patologia
Fenômenos Fisiológicos do Sistema Nervoso
Dinâmica não Linear
Projetos Piloto
Recidiva
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE


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[PMID]:28245448
[Au] Autor:Del Rey A; Besedovsky HO
[Ti] Título:Immune-Neuro-Endocrine Reflexes, Circuits, and Networks: Physiologic and Evolutionary Implications.
[So] Source:Front Horm Res;48:1-18, 2017.
[Is] ISSN:1662-3762
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The existence of a network of interactions between the immune and nervous systems that influences host defenses and brain functions is now well-established. Here we discuss how immune and classical neuro/sensorial signals are processed in the brain and how neuro-endocrine immunoregulatory and behavioral responses are integrated. Considering the ability of brain cells to produce cytokines, originally described as immune cell products, we propose that the tripartite synapse plays a central role in the integration of neuro-endocrine-immune interactions. We also propose that the immune-neuro-endocrine responses that influence the course of transmissible and other diseases predisposing to infections can be relevant for evolution, either by restoring health or by mediating an active process of negative selection.
[Mh] Termos MeSH primário: Evolução Biológica
Sistema Endócrino/fisiologia
Sistema Imunitário/fisiologia
Fenômenos Fisiológicos do Sistema Nervoso
Neuroimunomodulação/fisiologia
Sistemas Neurossecretores/fisiologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Fenômenos Fisiológicos do Sistema Nervoso/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171117
[Lr] Data última revisão:
171117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE
[do] DOI:10.1159/000452902



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