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Pesquisa : G11.561.653 [Categoria DeCS]
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  1 / 2149 MEDLINE  
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[PMID]:28916169
[Au] Autor:Gu T; Zhao T; Kohli U; Hewes RS
[Ad] Endereço:Department of Biology, University of Oklahoma, Norman, OK 73019, USA.
[Ti] Título:The large and small SPEN family proteins stimulate axon outgrowth during neurosecretory cell remodeling in Drosophila.
[So] Source:Dev Biol;431(2):226-238, 2017 11 15.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Split ends (SPEN) is the founding member of a well conserved family of nuclear proteins with critical functions in transcriptional regulation and the post-transcriptional processing and nuclear export of transcripts. In animals, the SPEN proteins fall into two size classes that perform either complementary or antagonistic functions in different cellular contexts. Here, we show that the two Drosophila representatives of this family, SPEN and Spenito (NITO), regulate metamorphic remodeling of the CCAP/bursicon neurosecretory cells. CCAP/bursicon cell-targeted overexpression of SPEN had no effect on the larval morphology or the pruning back of the CCAP/bursicon cell axons at the onset of metamorphosis. During the subsequent outgrowth phase of metamorphic remodeling, overexpression of either SPEN or NITO strongly inhibited axon extension, axon branching, peripheral neuropeptide accumulation, and soma growth. Cell-targeted loss-of-function alleles for both spen and nito caused similar reductions in axon outgrowth, indicating that the absolute levels of SPEN and NITO activity are critical to support the developmental plasticity of these neurons. Although nito RNAi did not affect SPEN protein levels, the phenotypes produced by SPEN overexpression were suppressed by nito RNAi. We propose that SPEN and NITO function additively or synergistically in the CCAP/bursicon neurons to regulate multiple aspects of neurite outgrowth during metamorphic remodeling.
[Mh] Termos MeSH primário: Proteínas de Drosophila/metabolismo
Drosophila melanogaster/metabolismo
Família Multigênica
Crescimento Neuronal
Sistemas Neurossecretores/citologia
Sistemas Neurossecretores/metabolismo
[Mh] Termos MeSH secundário: Animais
Larva/metabolismo
Neurônios/metabolismo
Neurossecreção
Terminações Pré-Sinápticas/metabolismo
Interferência de RNA
Asas de Animais/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Drosophila Proteins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170917
[St] Status:MEDLINE


  2 / 2149 MEDLINE  
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[PMID]:28804908
[Au] Autor:Dong B; Fan L; Wang Y; Chi C; Ma X; Wang R; Cai W; Shao X; Pan J; Zhu Y; Shangguan X; Xin Z; Hu J; Xie S; Kang X; Zhou L; Xue W
[Ad] Endereço:Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
[Ti] Título:Influence of abiraterone acetate on neuroendocrine differentiation in chemotherapy-naive metastatic castration-resistant prostate cancer.
[So] Source:Prostate;77(13):1373-1380, 2017 May.
[Is] ISSN:1097-0045
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To determine the influence of abiraterone Acetate (AA) on neuroendocrine differentiation (NED) in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (mCRPC). METHODS: We conducted an analysis in 115 chemotherapy-naïve mCRPC patients who would be treated with chemotherapy. The serum levels of chromogranin A (CgA), neurone-specific enolase (NSE) were measured in 67 mCRPC patients without AA treatment and 48 patients after the failure of AA treatment, in which these markers were also measured in 34 patients before and after 6 months of AA treatment. Comparative t-test was used to evaluate the serial changes of serum NED markers during AA treatment and univariate and multivariate analyses were performed to test the influence of AA treatment on NED. RESULTS: Serum CgA were NSE were evaluated to be above the upper limit of normal (ULN) in 56 (48.7%) and 29 (25.2%) patients before chemotherapy. In 34 patients with serial evaluation, serum CgA level of 14 patients and NSE of 14 patients increased after the failure of AA treatment. There was no significant difference of NED markers (CgA or NSE variation (P = 0.243) between at baseline and after the failure of AA treatment. Compared with the CgA elevation group in the first 6 months of AA treatment and baseline supranormal CgA group, the CgA decline group, and baseline normal CgA group has a much longer median PSA PFS (14.34 vs 10.00 months, P < 0.001, and 14.23 vs 10.30 months, P = 0.02) and rPFS, respectively (18.33 vs 11.37 months, P < 0.001, and 17.10 vs 12.07 months, P = 0.03). In logistic univariate analysis, AA treatment and its duration were not independent factors influencing NED. CONCLUSIONS: We hypothesized that AA might not significantly lead to progression of NED of mCRPC in general. Furthermore, we found there was heterogeneity in changes of NED markers in different mCRPC patients during AA treatment. Serial CgA and NSE evaluation might help clinicians guide clinical treatment of mCRPC patients.
[Mh] Termos MeSH primário: Acetato de Abiraterona
Adenocarcinoma
Biomarcadores
Cromogranina A
Neurossecreção
Próstata
Neoplasias de Próstata Resistentes à Castração
[Mh] Termos MeSH secundário: Acetato de Abiraterona/administração & dosagem
Acetato de Abiraterona/farmacocinética
Adenocarcinoma/tratamento farmacológico
Adenocarcinoma/metabolismo
Adenocarcinoma/patologia
Idoso
Antineoplásicos/administração & dosagem
Antineoplásicos/farmacocinética
Biomarcadores/sangue
Biomarcadores/metabolismo
China
Cromogranina A/sangue
Cromogranina A/metabolismo
Monitoramento de Medicamentos/métodos
Seres Humanos
Masculino
Meia-Idade
Neurossecreção/efeitos dos fármacos
Neurossecreção/fisiologia
Próstata/metabolismo
Próstata/patologia
Antígeno Prostático Específico/sangue
Neoplasias de Próstata Resistentes à Castração/tratamento farmacológico
Neoplasias de Próstata Resistentes à Castração/metabolismo
Neoplasias de Próstata Resistentes à Castração/patologia
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Biomarkers); 0 (Chromogranin A); EC 3.4.21.77 (Prostate-Specific Antigen); EM5OCB9YJ6 (Abiraterone Acetate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170815
[St] Status:MEDLINE
[do] DOI:10.1002/pros.23397


  3 / 2149 MEDLINE  
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[PMID]:28626074
[Au] Autor:Pitra S; Stern JE
[Ad] Endereço:Department of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia.
[Ti] Título:A-type K channels contribute to the prorenin increase of firing activity in hypothalamic vasopressin neurosecretory neurons.
[So] Source:Am J Physiol Heart Circ Physiol;313(3):H548-H557, 2017 Sep 01.
[Is] ISSN:1522-1539
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent studies have supported an important contribution of prorenin (PR) and its receptor (PRR) to the regulation of hypothalamic, sympathetic, and neurosecretory outflows to the cardiovascular system, including systemic release of vasopressin (VP), both under physiological and cardiovascular disease conditions. Still, the identification of precise cellular mechanisms and neuronal/molecular targets remain unknown. We have recently shown that PRR is expressed in VP neurons and that their activation increases neuronal activity. However, the underlying ionic channel mechanisms are undefined. Here, we performed patch-clamp electrophysiology from identified VP neurons in acute hypothalamic slices obtained from enhanced green fluorescent protein-VP transgenic rats. Voltage-clamp recordings showed that PR inhibited the magnitude of A-type K current ( ; ~50% at -25 mV), a subthreshold voltage-dependent current that restrains VP firing activity. PR also increased the inactivation rate of and shifted the steady-state voltage-dependent inactivation function toward more hyperpolarized membrane potential (~7 mV shift), thus resulting in less channel availability to be activated at any given membrane potential. PR also inhibited a sustained component of ("window" current). PR-mediated changes in action potential waveform and increased firing activity were occluded when was blocked by 4-aminopyridine. Finally, PR failed to increase superoxide production within the supraoptic nucleus/paraventricular nucleus, and PR excitatory effects persisted in slices treated with the SOD mimetic tempol. Taken together, these experiments indicated that PR excitatory effects on vasopressin neurons involve inhibition of , due, in part, to increases in its voltage-dependent inactivation properties. Moreover, our results indicate that PR effects did not involve an increase in oxidative stress. Here, we demonstrate that prorenin/the prorenin receptor is an important signaling unit for the regulation of vasopressin firing activity and, thus, systemic hormonal release. We identified A-type K channels as key molecular targets mediating prorenin stimulation of vasopressin neuronal activity, thus standing as a potential therapeutic target for neurohumoral activation in cardiovascular disease.
[Mh] Termos MeSH primário: Precursores Enzimáticos/farmacologia
Hipotálamo/efeitos dos fármacos
Neurônios/efeitos dos fármacos
Bloqueadores dos Canais de Potássio/farmacologia
Canais de Potássio de Abertura Dependente da Tensão da Membrana/antagonistas & inibidores
Renina/farmacologia
Vasopressinas/metabolismo
[Mh] Termos MeSH secundário: Potenciais de Ação
Animais
Genótipo
Proteínas de Fluorescência Verde/genética
Proteínas de Fluorescência Verde/metabolismo
Hipotálamo/citologia
Hipotálamo/metabolismo
Hipotálamo/secreção
Técnicas In Vitro
Ativação do Canal Iônico/efeitos dos fármacos
Masculino
Neurônios/metabolismo
Neurônios/secreção
Neurossecreção
Técnicas de Patch-Clamp
Fenótipo
Canais de Potássio de Abertura Dependente da Tensão da Membrana/metabolismo
Ratos Transgênicos
Ratos Wistar
Espécies Reativas de Oxigênio/metabolismo
Proteínas Recombinantes de Fusão/metabolismo
Fatores de Tempo
Vasopressinas/genética
Vasopressinas/secreção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Precursors); 0 (Potassium Channel Blockers); 0 (Potassium Channels, Voltage-Gated); 0 (Reactive Oxygen Species); 0 (Recombinant Fusion Proteins); 0 (enhanced green fluorescent protein); 11000-17-2 (Vasopressins); 147336-22-9 (Green Fluorescent Proteins); EC 3.4.23.15 (Renin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1152/ajpheart.00216.2017


  4 / 2149 MEDLINE  
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[PMID]:28384151
[Au] Autor:Banerjee N; Bhattacharya R; Gorczyca M; Collins KM; Francis MM
[Ad] Endereço:Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA United States of America.
[Ti] Título:Local neuropeptide signaling modulates serotonergic transmission to shape the temporal organization of C. elegans egg-laying behavior.
[So] Source:PLoS Genet;13(4):e1006697, 2017 Apr.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Animal behaviors are often composed of distinct alternating behavioral states. Neuromodulatory signals are thought to be critical for establishing stable behavioral states and for orchestrating transitions between them. However, we have only a limited understanding of how neuromodulatory systems act in vivo to alter circuit performance and shape behavior. To address these questions, we have investigated neuromodulatory signaling in the context of Caenorhabditis elegans egg-laying. Egg-laying activity cycles between discrete states-short bursts of egg deposition (active phases) that alternate with prolonged quiescent periods (inactive phases). Here using genetic, pharmacological and optogenetic approaches for cell-specific activation and inhibition, we show that a group of neurosecretory cells (uv1) located in close spatial proximity to the egg-laying neuromusculature direct the temporal organization of egg-laying by prolonging the duration of inactive phases. We demonstrate that the modulatory effects of the uv1 cells are mediated by peptides encoded by the nlp-7 and flp-11 genes that act locally to inhibit circuit activity, primarily by inhibiting vesicular release of serotonin from HSN motor neurons. This peptidergic inhibition is achieved, at least in part, by reducing synaptic vesicle abundance in the HSN motor neurons. By linking the in vivo actions of specific neuropeptide signaling systems with the generation of stable behavioral outcomes, our study reveals how cycles of neuromodulation emanating from non-neuronal cells can fundamentally shape the organization of a behavioral program.
[Mh] Termos MeSH primário: Proteínas de Caenorhabditis elegans/genética
Neuropeptídeos/genética
Oviposição/genética
[Mh] Termos MeSH secundário: Acetilcolina/metabolismo
Animais
Comportamento Animal
Caenorhabditis elegans/genética
Caenorhabditis elegans/fisiologia
Neurônios Motores/secreção
Neuropeptídeos/metabolismo
Neurossecreção/genética
Neurônios Serotoninérgicos/secreção
Serotonina/secreção
Transdução de Sinais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caenorhabditis elegans Proteins); 0 (Flp-2 protein, C elegans); 0 (Neuropeptides); 0 (Nlp-7 protein, C elegans); 333DO1RDJY (Serotonin); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1006697


  5 / 2149 MEDLINE  
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[PMID]:27377789
[Au] Autor:Tang A; Santesso DL; Segalowitz SJ; Schulkin J; Schmidt LA
[Ad] Endereço:Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, Canada. Electronic address: tanga6@mcmaster.ca.
[Ti] Título:Distinguishing shyness and sociability in adults: An event-related electrocortical-neuroendocrine study.
[So] Source:Biol Psychol;119:200-9, 2016 Sep.
[Is] ISSN:1873-6246
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Shyness and sociability are orthogonal personality dimensions, but little is known about how the two traits are instantiated in the brain and body. Using a 3-stimulus auditory oddball task, we examined whether shyness and sociability were distinguishable on P300 event-related potentials (ERPs) in processing task-relevant, novel, and standard auditory tones in 48 young adults. ERP amplitudes were measured at four midline scalp sites (Fz, FCz, Cz, Pz). We found that shyness, but not sociability, was related to reduced frontal novelty P300 amplitudes and to high emotionality. We also found that low baseline salivary cortisol levels mediated the relation between: (a) high shyness and reduced frontal P300 amplitudes to novel tones, and (b) high shyness and high scores of emotionality. We speculate that low baseline cortisol may serve as a putative mechanism influencing central attentional states of avoidance to threat and novelty and emotional arousal in adults who are shy.
[Mh] Termos MeSH primário: Nível de Alerta/fisiologia
Emoções/fisiologia
Potencial Evocado P300/fisiologia
Timidez
Habilidades Sociais
[Mh] Termos MeSH secundário: Adulto
Atenção/fisiologia
Aprendizagem da Esquiva/fisiologia
Metabolismo Basal/fisiologia
Encéfalo/fisiologia
Feminino
Seres Humanos
Hidrocortisona/análise
Hidrocortisona/secreção
Masculino
Neurossecreção/fisiologia
Comportamento Social
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160706
[St] Status:MEDLINE


  6 / 2149 MEDLINE  
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[PMID]:27119847
[Au] Autor:Grattan DR; Akopian AN
[Ad] Endereço:Centre for Neuroendocrinology and Department of Anatomy, University of Otago, Dunedin 9016, New Zealand. Electronic address: dave.grattan@otago.ac.nz.
[Ti] Título:Oscillating from Neurosecretion to Multitasking Dopamine Neurons.
[So] Source:Cell Rep;15(4):681-2, 2016 04 26.
[Is] ISSN:2211-1247
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this issue of Cell Reports, Stagkourakis et al. (2016) report that oscillating hypothalamic TIDA neurons, previously thought to be simple neurosecretory neurons controlling pituitary prolactin secretion, control dopamine output via autoregulatory mechanisms and thus could potentially regulate other physiologically important hypothalamic neuronal circuits.
[Mh] Termos MeSH primário: Neurônios Dopaminérgicos/metabolismo
Neurossecreção
[Mh] Termos MeSH secundário: Animais
Hipotálamo/metabolismo
Modelos Biológicos
Rede Nervosa/metabolismo
Neurônios/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160428
[St] Status:MEDLINE


  7 / 2149 MEDLINE  
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[PMID]:26108721
[Au] Autor:Schneggenburger R; Rosenmund C
[Ad] Endereço:Laboratory of Synaptic Mechanisms, Brain Mind Institute, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
[Ti] Título:Molecular mechanisms governing Ca(2+) regulation of evoked and spontaneous release.
[So] Source:Nat Neurosci;18(7):935-41, 2015 Jul.
[Is] ISSN:1546-1726
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The relationship between transmitter release evoked by action potentials and spontaneous release has fascinated neuroscientists for half a century, and separate biological roles for spontaneous release are emerging. Nevertheless, separate functions for spontaneous and Ca(2+)-evoked release do not necessarily indicate different origins of these two manifestations of vesicular fusion. Here we review how Ca(2+) regulates evoked and spontaneous release, emphasizing that Ca(2+) can briefly increase vesicle fusion rates one-millionfold above spontaneous rates. This high dynamic range suggests that docked and readily releasable pool (RRP) vesicles might be protected against spontaneous release while also being immediately available for ultrafast Ca(2+)-evoked release. Molecular mechanisms for such release clamping of highly fusogenic RRP vesicles are increasingly investigated. Thus, we view spontaneous release as a consequence of the highly release-competent state of a standing pool of RRP vesicles, which is molecularly fine-tuned to control spontaneous release.
[Mh] Termos MeSH primário: Cálcio/metabolismo
Neurossecreção/fisiologia
Transmissão Sináptica/fisiologia
Vesículas Sinápticas/metabolismo
[Mh] Termos MeSH secundário: Animais
Neurossecreção/genética
Transmissão Sináptica/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
SY7Q814VUP (Calcium)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150626
[St] Status:MEDLINE
[do] DOI:10.1038/nn.4044


  8 / 2149 MEDLINE  
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[PMID]:26081017
[Au] Autor:Nair-Collins M
[Ti] Título:Taking Science Seriously in the Debate on Death and Organ Transplantation.
[So] Source:Hastings Cent Rep;45(6):38-48, 2015 Nov-Dec.
[Is] ISSN:0093-0334
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The effort to develop international guidelines for determination of death purports to start with an objective examination of the biology of death. So far, however, it is showing once again how moral and metaphysical claims about death masquerade as scientific facts.
[Mh] Termos MeSH primário: Morte Encefálica/fisiopatologia
Formação de Conceito
Estado de Consciência
Transplante de Órgãos/ética
Política Pública
Coleta de Tecidos e Órgãos/ética
[Mh] Termos MeSH secundário: Comitês Consultivos
Morte Encefálica/legislação & jurisprudência
Morte
Dissidências e Disputas
Eletroencefalografia
Potenciais Somatossensoriais Evocados
Seres Humanos
Internacionalidade
Neurofisiologia
Neurossecreção
Transplante de Órgãos/legislação & jurisprudência
Guias de Prática Clínica como Assunto
Política Pública/legislação & jurisprudência
Política Pública/tendências
Coleta de Tecidos e Órgãos/legislação & jurisprudência
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1602
[Cu] Atualização por classe:151111
[Lr] Data última revisão:
151111
[Sb] Subgrupo de revista:E; IM
[Da] Data de entrada para processamento:150618
[St] Status:MEDLINE
[do] DOI:10.1002/hast.459


  9 / 2149 MEDLINE  
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[PMID]:26074004
[Au] Autor:Dus M; Lai JS; Gunapala KM; Min S; Tayler TD; Hergarden AC; Geraud E; Joseph CM; Suh GS
[Ad] Endereço:Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.
[Ti] Título:Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila.
[So] Source:Neuron;87(1):139-51, 2015 Jul 01.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Animals can detect and consume nutritive sugars without the influence of taste. However, the identity of the taste-independent nutrient sensor and the mechanism by which animals respond to the nutritional value of sugar are unclear. Here, we report that six neurosecretory cells in the Drosophila brain that produce Diuretic hormone 44 (Dh44), a homolog of the mammalian corticotropin-releasing hormone (CRH), were specifically activated by nutritive sugars. Flies in which the activity of these neurons or the expression of Dh44 was disrupted failed to select nutritive sugars. Manipulation of the function of Dh44 receptors had a similar effect. Notably, artificial activation of Dh44 receptor-1 neurons resulted in proboscis extensions and frequent episodes of excretion. Conversely, reduced Dh44 activity led to decreased excretion. Together, these actions facilitate ingestion and digestion of nutritive foods. We propose that the Dh44 system directs the detection and consumption of nutritive sugars through a positive feedback loop.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Proteínas de Drosophila/metabolismo
Comportamento Alimentar/fisiologia
Hormônios de Inseto/metabolismo
Neurônios/metabolismo
Adoçantes Calóricos/metabolismo
[Mh] Termos MeSH secundário: Animais
Drosophila
Proteínas de Drosophila/efeitos dos fármacos
Retroalimentação Sensorial
Frutose/farmacologia
Glucose/farmacologia
Neurossecreção/efeitos dos fármacos
Adoçantes Calóricos/farmacologia
Receptores de Superfície Celular/efeitos dos fármacos
Receptores de Superfície Celular/metabolismo
Trealose/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drome-DH(44) protein, Drosophila); 0 (Drosophila Proteins); 0 (Insect Hormones); 0 (Nutritive Sweeteners); 0 (Receptors, Cell Surface); 0 (diuretic hormone 44 receptor 1, Drosophila); 0 (diuretic hormone 44 receptor 2, Drosophila); 30237-26-4 (Fructose); B8WCK70T7I (Trehalose); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150616
[St] Status:MEDLINE


  10 / 2149 MEDLINE  
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[PMID]:25708831
[Au] Autor:Papadopulos A; Gomez GA; Martin S; Jackson J; Gormal RS; Keating DJ; Yap AS; Meunier FA
[Ad] Endereço:The Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia.
[Ti] Título:Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking.
[So] Source:Nat Commun;6:6297, 2015 Feb 24.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In neurosecretory cells, secretory vesicles (SVs) undergo Ca(2+)-dependent fusion with the plasma membrane to release neurotransmitters. How SVs cross the dense mesh of the cortical actin network to reach the plasma membrane remains unclear. Here we reveal that, in bovine chromaffin cells, SVs embedded in the cortical actin network undergo a highly synchronized transition towards the plasma membrane and Munc18-1-dependent docking in response to secretagogues. This movement coincides with a translocation of the cortical actin network in the same direction. Both effects are abolished by the knockdown or the pharmacological inhibition of myosin II, suggesting changes in actomyosin-generated forces across the cell cortex. Indeed, we report a reduction in cortical actin network tension elicited on secretagogue stimulation that is sensitive to myosin II inhibition. We reveal that the cortical actin network acts as a 'casting net' that undergoes activity-dependent relaxation, thereby driving tethered SVs towards the plasma membrane where they undergo Munc18-1-dependent docking.
[Mh] Termos MeSH primário: Actinas/metabolismo
Células Cromafins/fisiologia
Proteínas Munc18/metabolismo
Miosina Tipo II/metabolismo
Neurossecreção
Vesículas Secretórias/fisiologia
[Mh] Termos MeSH secundário: Animais
Bovinos
Compostos Heterocíclicos de 4 ou mais Anéis
Células PC12
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Actins); 0 (Heterocyclic Compounds, 4 or More Rings); 0 (Munc18 Proteins); 20WC4J7CQ6 (blebbistatin); EC 3.6.1.- (Myosin Type II)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150225
[St] Status:MEDLINE
[do] DOI:10.1038/ncomms7297



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