Base de dados : MEDLINE
Pesquisa : G11.561.731.127 [Categoria DeCS]
Referências encontradas : 4273 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 428 ir para página                         

  1 / 4273 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29300752
[Au] Autor:Schumacher S; Oe M; Wilhelm FH; Rufer M; Heinrichs M; Weidt S; Moergeli H; Martin-Soelch C
[Ad] Endereço:Department of Psychiatry and Psychotherapy, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
[Ti] Título:Does trait anxiety influence effects of oxytocin on eye-blink startle reactivity? A randomized, double-blind, placebo-controlled crossover study.
[So] Source:PLoS One;13(1):e0190809, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Previous research has demonstrated that the neuropeptide oxytocin modulates social behaviors and reduces anxiety. However, effects of oxytocin on startle reactivity, a well-validated measure of defense system activation related to fear and anxiety, have been inconsistent. Here we investigated the influence of oxytocin on startle reactivity with particular focus on the role of trait anxiety. METHODS: Forty-four healthy male participants attended two experimental sessions. They received intranasal oxytocin (24 IU) in one session and placebo in the other. Startle probes were presented in combination with pictures of social and non-social content. Eye-blink startle magnitude was measured by electromyography over the musculus orbicularis oculi in response to 95 dB noise bursts. Participants were assigned to groups of high vs. low trait anxiety based on their scores on the trait form of the Spielberger State-Trait Anxiety Inventory (STAI). RESULTS: A significant interaction effect of oxytocin with STAI confirmed that trait anxiety moderated the effect of oxytocin on startle reactivity. Post-hoc tests indicated that for participants with elevated trait anxiety, oxytocin increased startle magnitude, particularly when watching non-social pictures, while this was not the case for participants with low trait anxiety. CONCLUSION: Results indicate that effects of oxytocin on defense system activation depend on individual differences in trait anxiety. Trait anxiety may be an important moderator variable that should be considered in human studies on oxytocin effects.
[Mh] Termos MeSH primário: Ansiedade/fisiopatologia
Ocitocina/fisiologia
Reflexo de Sobressalto/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Piscadela/efeitos dos fármacos
Piscadela/fisiologia
Estudos Cross-Over
Método Duplo-Cego
Seres Humanos
Masculino
Meia-Idade
Ocitocina/farmacologia
Personalidade/fisiologia
Reflexo de Sobressalto/efeitos dos fármacos
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
50-56-6 (Oxytocin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190809


  2 / 4273 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28465091
[Au] Autor:Garaszczuk IK; Iskander DR
[Ad] Endereço:Department of Biomedical Engineering, Wroclaw University of Science Technology, Poland. Electronic address: Izabela.garaszczuk@uv.es.
[Ti] Título:Qualitative assessment of tear dynamics with fluorescein profilometry.
[So] Source:Cont Lens Anterior Eye;40(4):208-212, 2017 Aug.
[Is] ISSN:1476-5411
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To describe a new methodology for tear-film dynamics assessment by observing fluorescein decay rate over time and to understand the relationship between the newly defined tear fluorescein washout rate (TFWR) and other measures of the tear film behaviour. METHODS: Forty subjects (24F/16M) aged (mean±standard deviation) 31.8±14.2years volunteered for the study. It consisted of the review of medical history, McMonnies questionnaire (McMQ), slit lamp examination, and TFWR using a newly-developed fluorescein profilometry. The repeatability of TFWR measurements was assessed. TFWR estimates were contrasted against patient age, McMQ score, daytime, fluorescein tear film break-up time (FTBUT), tear meniscus height (TMH) and blink frequency. RESULTS: Mean repeatability of the method was 28.13±9.59%. The group mean TFWR was 39±23% at 30-s mark after the beginning of measurements, ranging from 1.4% to 83%. This indicates that TFWR is highly subject-dependent. Statistically significant correlations were found between the percentage TFWR and McMQ score (r =0.214, p=0.001) as well as FTBUT (r =0.136, p=0.009). No statistically significant correlations were found between TFWR and age, daytime, TMH, and blink frequency. CONCLUSIONS: Fluorescein profilometry allows clinicians to follow dynamic changes in the tear film on the entire ocular surface and may be used for qualitative assessment of the tear film dynamics.
[Mh] Termos MeSH primário: Piscadela/fisiologia
Síndromes do Olho Seco/diagnóstico
Fluoresceína/farmacocinética
Lágrimas/fisiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Síndromes do Olho Seco/metabolismo
Síndromes do Olho Seco/fisiopatologia
Feminino
Fluoresceína/administração & dosagem
Corantes Fluorescentes/administração & dosagem
Corantes Fluorescentes/farmacocinética
Voluntários Saudáveis
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluorescent Dyes); TPY09G7XIR (Fluorescein)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


  3 / 4273 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29216226
[Au] Autor:Finke JB; Larra MF; Merz MU; Schächinger H
[Ad] Endereço:Institute of Psychobiology, Department of Clinical Psychophysiology, University of Trier, Trier, Germany.
[Ti] Título:Startling similarity: Effects of facial self-resemblance and familiarity on the processing of emotional faces.
[So] Source:PLoS One;12(12):e0189028, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Facial self-resemblance has been associated with positive emotional evaluations, but this effect may be biased by self-face familiarity. Here we report two experiments utilizing startle modulation to investigate how the processing of facial expressions of emotion is affected by subtle resemblance to the self as well as to familiar faces. Participants of the first experiment (I) (N = 39) were presented with morphed faces showing happy, neutral, and fearful expressions which were manipulated to resemble either their own or unknown faces. At SOAs of either 300 ms or 3500-4500 ms after picture onset, startle responses were elicited by binaural bursts of white noise (50 ms, 105 dB), and recorded at the orbicularis oculi via EMG. Manual reaction time was measured in a simple emotion discrimination paradigm. Pictures preceding noise bursts by short SOA inhibited startle (prepulse inhibition, PPI). Both affective modulation and PPI of startle in response to emotional faces was altered by physical similarity to the self. As indexed both by relative facilitation of startle and faster manual responses, self-resemblance apparently induced deeper processing of facial affect, particularly in happy faces. Experiment II (N = 54) produced similar findings using morphs of famous faces, yet showed no impact of mere familiarity on PPI effects (or response time, either). The results are discussed with respect to differential (presumably pre-attentive) effects of self-specific vs. familiar information in face processing.
[Mh] Termos MeSH primário: Emoções
Reconhecimento Facial
[Mh] Termos MeSH secundário: Adulto
Piscadela
Eletromiografia
Feminino
Seres Humanos
Masculino
Tempo de Reação
Reflexo de Sobressalto
Análise e Desempenho de Tarefas
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189028


  4 / 4273 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28961277
[Au] Autor:Van Slooten JC; Jahfari S; Knapen T; Theeuwes J
[Ad] Endereço:Department of Applied and Experimental Psychology, Vrije Universiteit, Amsterdam, Noord-Holland, The Netherlands.
[Ti] Título:Individual differences in eye blink rate predict both transient and tonic pupil responses during reversal learning.
[So] Source:PLoS One;12(9):e0185665, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The pupil response under constant illumination can be used as a marker of cognitive processes. In the past, pupillary responses have been studied in the context of arousal and decision-making. However, recent work involving Parkinson's patients suggested that pupillary responses are additionally affected by reward sensitivity. Here, we build on these findings by examining how pupil responses are modulated by reward and loss while participants (N = 30) performed a Pavlovian reversal learning task. In fast (transient) pupil responses, we observed arousal-based influences on pupil size both during the expectation of upcoming value and the evaluation of unexpected monetary outcomes. Importantly, after incorporating eye blink rate (EBR), a behavioral correlate of striatal dopamine levels, we observed that participants with lower EBR showed stronger pupil dilation during the expectation of upcoming reward. Subsequently, when reward expectations were violated, participants with lower EBR showed stronger pupil responses after experiencing unexpected loss. Across trials, the detection of a reward contingency reversal was reflected in a slow (tonic) dilatory pupil response observed already several trials prior to the behavioral report. Interestingly, EBR correlated positively with this tonic detection response, suggesting that variability in the arousal-based detection response may reflect individual differences in striatal dopaminergic tone. Our results provide evidence that a behavioral marker of baseline striatal dopamine level (EBR) can potentially be used to describe the differential effects of value-based learning in the arousal-based pupil response.
[Mh] Termos MeSH primário: Piscadela
Aprendizagem
Pupila/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Movimentos Oculares
Feminino
Seres Humanos
Masculino
Estimulação Luminosa
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170930
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185665


  5 / 4273 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28914003
[Au] Autor:Kim DJ; Lim CY; Gu N; Park CY
[Ad] Endereço:Department of Ophthalmology, Dongguk University Ilsan Hospital, Goyang, Korea.
[Ti] Título:Visual Fatigue Induced by Viewing a Tablet Computer with a High-resolution Display.
[So] Source:Korean J Ophthalmol;31(5):388-393, 2017 Oct.
[Is] ISSN:2092-9382
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:PURPOSE: In the present study, the visual discomfort induced by smart mobile devices was assessed in normal and healthy adults. METHODS: Fifty-nine volunteers (age, 38.16 ± 10.23 years; male : female = 19 : 40) were exposed to tablet computer screen stimuli (iPad Air, Apple Inc.) for 1 hour. Participants watched a movie or played a computer game on the tablet computer. Visual fatigue and discomfort were assessed using an asthenopia questionnaire, tear film break-up time, and total ocular wavefront aberration before and after viewing smart mobile devices. RESULTS: Based on the questionnaire, viewing smart mobile devices for 1 hour significantly increased mean total asthenopia score from 19.59 ± 8.58 to 22.68 ± 9.39 (p < 0.001). Specifically, the scores for five items (tired eyes, sore/aching eyes, irritated eyes, watery eyes, and hot/burning eye) were significantly increased by viewing smart mobile devices. Tear film break-up time significantly decreased from 5.09 ± 1.52 seconds to 4.63 ± 1.34 seconds (p = 0.003). However, total ocular wavefront aberration was unchanged. CONCLUSIONS: Visual fatigue and discomfort were significantly induced by viewing smart mobile devices, even though the devices were equipped with state-of-the-art display technology.
[Mh] Termos MeSH primário: Astenopia/etiologia
Piscadela/fisiologia
Computadores de Mão
[Mh] Termos MeSH secundário: Adulto
Idoso
Astenopia/diagnóstico
Astenopia/fisiopatologia
Feminino
Voluntários Saudáveis
Seres Humanos
Imagem Tridimensional
Masculino
Meia-Idade
Estudos Prospectivos
Inquéritos e Questionários
Lágrimas/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.3341/kjo.2016.0095


  6 / 4273 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28886090
[Au] Autor:Kaido M; Kawashima M; Shigeno Y; Yamada Y; Tsubota K
[Ad] Endereço:Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
[Ti] Título:Relation of accommodative microfluctuation with dry eye symptoms in short tear break-up time dry eye.
[So] Source:PLoS One;12(9):e0184296, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate accommodative microfluctuations (AMFs) and visual function in short tear break-up time (BUT)-type dry eye (DE) and non-DE subjects. METHODS: This prospective comparative study included 48 volunteers with DE symptoms (mean age 34.8 ± 5.5 years, age range 25-42 years) and 73 without DE symptoms (mean age 30.6 ± 4.7 years, age range 25-42 years). The eyes were divided into two groups: (1) DE group with DE symptoms and BUT ≤ 5 s and (2) non-DE group without DE symptoms and BUT > 5 s. We excluded eyes with Schirmer score ≤ 5 mm and positive keratoconjunctival epithelial damage. Tear evaluation, AMF, and functional visual acuity (VA) examinations were performed. AMF parameters included total high-frequency component (HFC), HFC with low accommodation for the task of staring into the distance (HFC1), and HFC with high accommodation for deskwork (HFC2). Functional VA parameters included starting VA, functional VA, visual maintenance ratio, and blink frequency. RESULTS: A total of 33 and 34 eyes were categorized in the DE and non-DE groups, respectively. Mean blink frequency and HFC1 values were significantly higher in the DE group than they were in the non-DE group. CONCLUSIONS: DEs with symptoms showed abnormal AMF and visual function, which may be associated with DE symptoms.
[Mh] Termos MeSH primário: Lágrimas/secreção
Xeroftalmia/etiologia
Xeroftalmia/fisiopatologia
[Mh] Termos MeSH secundário: Acomodação Ocular
Adulto
Piscadela
Feminino
Seres Humanos
Masculino
Prevalência
Refração Ocular
Acuidade Visual
Xeroftalmia/diagnóstico
Xeroftalmia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184296


  7 / 4273 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28869676
[Au] Autor:Weissbach A; Werner E; Bally JF; Tunc S; Löns S; Timmann D; Zeuner KE; Tadic V; Brüggemann N; Lang A; Klein C; Münchau A; Bäumer T
[Ad] Endereço:Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.
[Ti] Título:Alcohol improves cerebellar learning deficit in myoclonus-dystonia: A clinical and electrophysiological investigation.
[So] Source:Ann Neurol;82(4):543-553, 2017 Oct.
[Is] ISSN:1531-8249
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To characterize neurophysiological subcortical abnormalities in myoclonus-dystonia and their modulation by alcohol administration. METHODS: Cerebellar associative learning and basal ganglia-brainstem interaction were investigated in 17 myoclonus-dystonia patients with epsilon-sarcoglycan (SGCE) gene mutation and 21 age- and sex-matched healthy controls by means of classical eyeblink conditioning and blink reflex recovery cycle before and after alcohol intake resulting in a breath alcohol concentration of 0.08% (0.8g/l). The alcohol responsiveness of clinical symptoms was evaluated by 3 blinded raters with a standardized video protocol and clinical rating scales including the Unified Myoclonus Rating Scale and the Burke-Fahn-Marsden Dystonia Rating Scale. RESULTS: Patients showed a significantly reduced number of conditioned eyeblink responses before alcohol administration compared to controls. Whereas the conditioning response rate decreased under alcohol intake in controls, it increased in patients (analysis of variance: alcohol state × group, p = 0.004). Blink reflex recovery cycle before and after alcohol intake did not differ between groups. Myoclonus improved significantly after alcohol intake (p = 0.016). The severity of action myoclonus at baseline correlated negatively with the conditioning response in classical eyeblink conditioning in patients. INTERPRETATION: The combination of findings of reduced baseline acquisition of conditioned eyeblink responses and normal blink reflex recovery cycle in patients who improved significantly with alcohol intake suggests a crucial role of cerebellar networks in the generation of symptoms in these patients. Ann Neurol 2017;82:543-553.
[Mh] Termos MeSH primário: Piscadela/efeitos dos fármacos
Distúrbios Distônicos/complicações
Etanol/administração & dosagem
Etanol/farmacologia
Transtornos de Aprendizagem/tratamento farmacológico
Transtornos de Aprendizagem/etiologia
[Mh] Termos MeSH secundário: Administração por Inalação
Adolescente
Adulto
Estudos de Casos e Controles
Depressores do Sistema Nervoso Central/administração & dosagem
Depressores do Sistema Nervoso Central/farmacologia
Condicionamento Clássico/efeitos dos fármacos
Distúrbios Distônicos/genética
Eletromiografia
Feminino
Seres Humanos
Masculino
Meia-Idade
Mutação/genética
Sarcoglicanas/genética
Índice de Gravidade de Doença
Gravação em Vídeo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Central Nervous System Depressants); 0 (SGCE protein, human); 0 (Sarcoglycans); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE
[do] DOI:10.1002/ana.25035


  8 / 4273 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28673750
[Au] Autor:Koh S; Inoue Y; Ochi S; Takai Y; Maeda N; Nishida K
[Ad] Endereço:Department of Innovative Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan. Electronic address: skoh@ophthal.med.osaka-u.ac.jp.
[Ti] Título:Quality of Vision in Eyes With Epiphora Undergoing Lacrimal Passage Intubation.
[So] Source:Am J Ophthalmol;181:71-78, 2017 Sep.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate visual function and optical quality in eyes with epiphora undergoing lacrimal passage intubation. DESIGN: Prospective case series. METHODS: Thirty-four eyes of 30 patients with lacrimal passage obstruction were enrolled. Before and 1 month after lacrimal passage intubation, functional visual acuity (FVA), higher-order aberrations (HOAs), lower tear meniscus, and tear clearance were assessed. An FVA measurement system was used to examine changes in continuous visual acuity (VA) over time, and visual function parameters such as FVA, visual maintenance ratio, and blink frequency were obtained. Sequential ocular HOAs were measured for 10 seconds after the blink using a wavefront sensor. Aberration data were analyzed in the central 4 mm for coma-like, spherical-like, and total HOAs. Fluctuation and stability indices of the total HOAs over time were calculated. Lower tear meniscus was assessed by anterior segment optical coherence tomography. RESULTS: After lacrimal passage intubation, visual function significantly improved, as indicated by improved FVA (P = .003) and visual maintenance ratio (P < .001). Blink frequency decreased significantly after treatment (P = .01). Optical quality significantly improved, as indicated by a decrease in coma-like aberrations (P = .003), spherical-like aberrations (P = .018), and total HOAs (P = .001). Stability index increased (P < .001) and fluctuation index decreased (P = .019), and tear meniscus dimension decreased (P < .001). CONCLUSIONS: Lacrimal passage intubation for eyes with epiphora significantly improved visual function and optical quality via patency of the lacrimal passage.
[Mh] Termos MeSH primário: Intubação
Doenças do Aparelho Lacrimal/terapia
Obstrução dos Ductos Lacrimais/terapia
Visão Ocular/fisiologia
Acuidade Visual/fisiologia
[Mh] Termos MeSH secundário: Idoso
Piscadela/fisiologia
Feminino
Seres Humanos
Doenças do Aparelho Lacrimal/fisiopatologia
Doenças do Aparelho Lacrimal/psicologia
Obstrução dos Ductos Lacrimais/fisiopatologia
Obstrução dos Ductos Lacrimais/psicologia
Masculino
Meia-Idade
Estudos Prospectivos
Qualidade de Vida/psicologia
Lágrimas/química
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE


  9 / 4273 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28575003
[Au] Autor:Yao J; Wu B; Wu GY; Li X; Ye JN; Sui JF
[Ad] Endereço:Department of Physiology, College of Basic Medical Science, Third Military Medical University, Chongqing, P.R. China.
[Ti] Título:Establishment and transfer of classical eyeblink conditioning using electrical microstimulation of the hippocampus as the conditioned stimulus.
[So] Source:PLoS One;12(6):e0178502, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present experiment was designed to determine whether classical eyeblink conditioning (EBC) can be established by using electrical microstimulation of the hippocampus as a conditioned stimulus (CS) paired with an air-puff unconditioned stimulus (US). We intended to examine whether EBC transfer could occur when a CS was shifted between microstimulation of the hippocampus as a CS (Hip-CS) and tone as a CS (tone-CS) and to compare the difference in transfer effectiveness between delay EBC (dEBC) and trace EBC (tEBC). Eight groups of guinea pigs, including 4 experimental groups and 4 control groups, were included in the study. First, the experimental groups received either a Hip-CS or a tone-CS paired with a US; then, these groups were exposed to a shifted CS (tone-CS or Hip-CS) paired with the US. The control groups received the corresponding Hip-CS or tone-CS, which was, however, pseudo-paired with the US. The control groups were then shifted to the tone-CS (or Hip-CS) paired with the US. The results show that EBC can be successfully established when using microstimulation of the hippocampus as a CS paired with an air-puff US, and that the acquisition rates of EBC are higher in the experimental groups than in the control groups after switching from the Hip-CS to the tone-CS or vice versa, indicating the occurrence of learning transfer between EBC established with the Hip-CS and tone-CS. The present study also demonstrated that the EBC re-acquisition rates were remarkably higher in dEBC than in tEBC with both types of transfer, which suggests that the saving effect was more evident in dEBC than tEBC. These results significantly expand our knowledge of EBC transfer as well as the functional neural circuit underlying EBC transfer.
[Mh] Termos MeSH primário: Piscadela
Condicionamento Palpebral/fisiologia
Hipocampo/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal
Cobaias
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178502


  10 / 4273 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28569172
[Au] Autor:Trbolova A; Ghaffari MS
[Ad] Endereço:Clinic of Small Animals, University of Veterinary Medicine and Pharmacy, Kosice, Slovakia.
[Ti] Título:Results of the Schirmer tear test performed with open and closed eyes in clinically normal horses.
[So] Source:Acta Vet Scand;59(1):35, 2017 May 31.
[Is] ISSN:1751-0147
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The Schirmer tear test (STT) is widely used in both human and veterinary ophthalmology. Two types of STTs have been developed: STT I and SST II. The STT I measures the basal and reflex tear production and is the most widely used STT. However, several factors influence the STT results such as the person performing the test and the location of the strip placement within the conjunctival sac. The aim of this study was to measure the basal and reflex tear production (STT I) in clinically normal horses with open versus closed eyes. RESULTS: Forty clinically healthy horses without any ocular diseases were included. On day 1, the STT I was first performed on all the horses with the eyes open followed by an STT I with closed eyes performed 30 min later. On day 2, all horses had their eyes closed during the first STT and the eyes open during the second test performed 30 min later. The mean value of the STTs performed on open eye was significantly less than the STT performed on closed eye on both days of examination. CONCLUSION: This study showed a small but statistically significant difference between STT values obtained with open versus closed eyes in clinically normal horses.
[Mh] Termos MeSH primário: Piscadela/fisiologia
Técnicas de Diagnóstico Oftalmológico/veterinária
Cavalos/fisiologia
Lágrimas/secreção
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Valores de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1186/s13028-017-0303-2



página 1 de 428 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde