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[PMID]:28743726
[Au] Autor:Chen Y; Chen L; Wang Y; Chen XY; Wolpaw JR
[Ad] Endereço:National Center for Adaptive Neurotechnologies, Wadsworth Center, New York State Department Health, Albany, New York 12201-0509.
[Ti] Título:Why New Spinal Cord Plasticity Does Not Disrupt Old Motor Behaviors.
[So] Source:J Neurosci;37(34):8198-8206, 2017 Aug 23.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:When new motor learning changes the spinal cord, old behaviors are not impaired; their key features are preserved by additional compensatory plasticity. To explore the mechanisms responsible for this compensatory plasticity, we transected the spinal dorsal ascending tract before or after female rats acquired a new behavior-operantly conditioned increase or decrease in the right soleus H-reflex-and examined an old behavior-locomotion. Neither spinal dorsal ascending tract transection nor H-reflex conditioning alone impaired locomotion. Nevertheless, when spinal dorsal ascending tract transection and H-reflex conditioning were combined, the rats developed a limp and a tilted posture that correlated in direction and magnitude with the H-reflex change. When the right H-reflex was increased by conditioning, the right step lasted longer than the left and the right hip was higher than the left; when the right H-reflex was decreased by conditioning, the opposite occurred. These results indicate that ascending sensory input guides the compensatory plasticity that normally prevents the plasticity underlying H-reflex change from impairing locomotion. They support the concept of the state of the spinal cord as a negotiated equilibrium that reflects the concurrent influences of all the behaviors in an individual's repertoire; and they support the new therapeutic strategies this concept introduces. The spinal cord provides a reliable final common pathway for motor behaviors throughout life. Until recently, its reliability was explained by the assumption that it is hardwired; but it is now clear that the spinal cord changes continually as new behaviors are acquired. Nevertheless, old behaviors are preserved. This study shows that their preservation depends on sensory feedback from the spinal cord to the brain: if feedback is removed, the acquisition of a new behavior may disrupt an old behavior. In sum, when a new behavior changes the spinal cord, sensory feedback to the brain guides further change that preserves old behaviors. This finding contributes to a new understanding of spinal cord function and to development of new rehabilitation therapies.
[Mh] Termos MeSH primário: Reflexo H/fisiologia
Atividade Motora/fisiologia
Plasticidade Neuronal/fisiologia
Medula Espinal/fisiologia
[Mh] Termos MeSH secundário: Animais
Eletromiografia/métodos
Feminino
Distribuição Aleatória
Ratos
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.0767-17.2017


  2 / 2404 MEDLINE  
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[PMID]:29244850
[Au] Autor:Serrano-Muñoz D; Gómez-Soriano J; Bravo-Esteban E; Vázquez-Fariñas M; Taylor J; Avendaño-Coy J
[Ad] Endereço:Sensorimotor Function Group, Hospital Nacional de Parapléjicos, Toledo, Spain.
[Ti] Título:Intensity matters: Therapist-dependent dose of spinal transcutaneous electrical nerve stimulation.
[So] Source:PLoS One;12(12):e0189734, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The intensity used during transcutaneous electrical nerve stimulation (TENS) in both, clinical practice and research studies, is often based on subjective commands such as "strong but comfortable sensation". There is no consensus regarding the effectiveness dose of TENS. The objective was to determine the difference in the effect of spinal TENS on soleus H-reflex modulation when applied by two therapists instructed to apply the stimulation at a "strong but comfortable" intensity. Twenty healthy volunteers divided into two groups: Therapist 1 (n = 10) and Therapist 2 (n = 10). Both therapist applied spinal TENS and sham stimulation at the T10-12 spinal level for 40min in random order to each subject, at an intensity designed to produce a "strong but comfortable" sensation. To avoid habituation, the intensity was adjusted every 2min. Soleus H-reflex was recorded before, during, and 10min after TENS by an observer blinded to the stimulus applied. Despite the instruction to apply TENS at a "strong comfortable" level, a significant difference in current density was identified: Therapist 1 (0.67mA/cm2, SD 0.54) applied more than Therapist 2 (0.53mA/cm2, SD 0.57; p<0.001) at the onset of the intervention. Maximal peak-to-peak H-reflex amplitude was inhibited significantly more 10min following TENS applied by Therapist 1 (-0.15mV, SD 0.16) compared with Therapist 2 (0.04mV, SD 0.16; p = 0.03). Furthermore, current density significantly correlated with the inhibitory effect on peak-to-peak Soleus H-reflex amplitude 10 min after stimulation (Rho = -0.38; p = 0.04). TENS intensity dosage by the therapist based on the subjective perception of the participants alone is unreliable and requires objective standardization. In addition, higher current density TENS produced greater inhibition of the Soleus H-reflex.
[Mh] Termos MeSH primário: Reflexo H/fisiologia
Músculo Esquelético/efeitos da radiação
Estimulação Elétrica Nervosa Transcutânea/normas
[Mh] Termos MeSH secundário: Adulto
Feminino
Voluntários Saudáveis
Seres Humanos
Masculino
Músculo Esquelético/inervação
Músculo Esquelético/fisiopatologia
Fisioterapeutas
Estimulação Elétrica Nervosa Transcutânea/métodos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189734


  3 / 2404 MEDLINE  
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[PMID]:28510605
[Au] Autor:Puglisi G; Leonetti A; Landau A; Fornia L; Cerri G; Borroni P
[Ad] Endereço:Department of Health Sciences, University of Milano, Medical School, Milan, Italy.
[Ti] Título:The role of attention in human motor resonance.
[So] Source:PLoS One;12(5):e0177457, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Observation of others' actions evokes in primary motor cortex and spinal circuits of observers a subliminal motor resonance response, which reflects the motor program encoding observed actions. We investigated the role of attention in human motor resonance with four experimental conditions, explored in different subject groups: in the first explicit condition, subjects were asked to observe a rhythmic hand flexion-extension movement performed live in front of them. In two other conditions subjects had to monitor the activity of a LED light mounted on the oscillating hand. The hand was clearly visible but it was not the focus of subjects' attention: in the semi-implicit condition hand movement was relevant to task completion, while in the implicit condition it was irrelevant. In a fourth, baseline, condition subjects observed the rhythmic oscillation of a metal platform. Motor resonance was measured with the H-reflex technique as the excitability modulation of cortico-spinal motorneurons driving a hand flexor muscle. As expected, a normal resonant response developed in the explicit condition, and no resonant response in the baseline condition. Resonant responses also developed in both semi-implicit and implicit conditions and, surprisingly, were not different from each other, indicating that viewing an action is, per se, a powerful stimulus for the action observation network, even when it is not the primary focus of subjects' attention and even when irrelevant to the task. However, the amplitude of these responses was much reduced compared to the explicit condition, and the phase-lock between the time courses of observed movement and resonant motor program was lost. In conclusion, different parameters of the response were differently affected by subtraction of attentional resources with respect to the explicit condition: time course and muscle selection were preserved while the activation of motor circuits resulted in much reduced amplitude and lost its kinematic specificity.
[Mh] Termos MeSH primário: Atenção
Córtex Motor/fisiologia
Desempenho Psicomotor
[Mh] Termos MeSH secundário: Adulto
Potencial Evocado Motor
Feminino
Reflexo H
Seres Humanos
Masculino
Músculo Esquelético/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177457


  4 / 2404 MEDLINE  
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[PMID]:28398968
[Au] Autor:Fernández-Lago H; Bello O; Mora-Cerdá F; Montero-Cámara J; Fernández-Del-Olmo MÁ
[Ad] Endereço:From the Faculty of Sciences of Sport and Physical Education, Department of Physical Education, University of A Coruña, A Coruña, Spain (HF-L, FM-C, JM-C, MÁF-d-O); and Physical Therapy Department, Faculty of Physical Therapy, University of A Coruña, A Coruña, Spain (OB).
[Ti] Título:Treadmill Walking Combined With Anodal Transcranial Direct Current Stimulation in Parkinson Disease: A Pilot Study of Kinematic and Neurophysiological Effects.
[So] Source:Am J Phys Med Rehabil;96(11):801-808, 2017 Nov.
[Is] ISSN:1537-7385
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We tested the hypothesis that combining treadmill walking with transcranial direct current stimulation (tDCS) enhances the gait improvements associated with treadmill walking in Parkinson disease. We explored the effects of these combined methodologies on corticospinal parameters. DESIGN: Eighteen participants with Parkinson disease were evaluated under the following three conditions: treadmill walking alone (treadmill), treadmill walking combined with anodal tDCS (AtDCS+treadmill) delivered over the motor cortex, and treadmill walking combined with sham stimulation (StDCS+treadmill). Overground walking performance, soleus H-reflex, reciprocal Ia inhibition from the tibialis anterior to the soleus muscle, intracortical facilitation, and short intracortical inhibition of the tibialis anterior muscle, were measured before and after each treadmill condition. The soleus H-reflex and walking performance on the treadmill were also evaluated. RESULTS: All treadmill conditions improved walking performance and modulated spinal and corticospinal parameters in a similar way. However, AtDCS+treadmill lead to a different modulation of reciprocal Ia inhibition in comparison with the other treadmill conditions. CONCLUSIONS: A single session combining treadmill walking and anodal tDCS delivered over the motor cortex resulted in a specific modulation of the reciprocal Ia inhibition from the tibialis anterior to the soleus muscle. However, this acute effect did not result in improvements of gait parameters associated with treadmill walking in Parkinson disease.
[Mh] Termos MeSH primário: Terapia por Exercício/métodos
Doença de Parkinson/fisiopatologia
Doença de Parkinson/reabilitação
Estimulação Transcraniana por Corrente Contínua/métodos
Caminhada/fisiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Fenômenos Biomecânicos/fisiologia
Terapia Combinada
Potencial Evocado Motor/fisiologia
Teste de Esforço/métodos
Feminino
Reflexo H/fisiologia
Seres Humanos
Masculino
Meia-Idade
Córtex Motor/fisiopatologia
Músculo Esquelético/fisiopatologia
Projetos Piloto
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.1097/PHM.0000000000000751


  5 / 2404 MEDLINE  
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[PMID]:28315725
[Au] Autor:Yen CL; McHenry CL; Petrie MA; Dudley-Javoroski S; Shields RK
[Ad] Endereço:Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA, 52242, United States.
[Ti] Título:Vibration training after chronic spinal cord injury: Evidence for persistent segmental plasticity.
[So] Source:Neurosci Lett;647:129-132, 2017 Apr 24.
[Is] ISSN:1872-7972
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:H-reflex paired-pulse depression is gradually lost within the first year post-SCI, a process believed to reflect reorganization of segmental interneurons after the loss of normal descending (cortical) inhibition. This reorganization co-varies in time with the development of involuntary spasms and spasticity. The purpose of this study is to determine whether long-term vibration training may initiate the return of H-reflex paired-pulse depression in individuals with chronic, complete SCI. Five men with SCI received twice-weekly vibration training (30Hz, 0.6g) to one lower limb while seated in a wheelchair. The contra-lateral limb served as a within-subject control. Paired-pulse H-reflexes were obtained before, during, and after a session of vibration. Untrained limb H-reflex depression values were comparable to chronic SCI values from previous reports. In contrast, the trained limbs of all 5 participants showed depression values that were within the range of previously-reported Acute SCI and Non-SCI H-reflex depression. The average difference between limbs was 34.98% (p=0.016). This evidence for the return of H-reflex depression suggests that even for people with long-standing SCI, plasticity persists in segmental reflex pathways. The spinal networks involved with the clinical manifestation of spasticity may thus retain adaptive plasticity after long-term SCI. The results of this study indicate that vibration training may hold promise as an anti-spasticity rehabilitation intervention.
[Mh] Termos MeSH primário: Reflexo H
Plasticidade Neuronal
Traumatismos da Medula Espinal/reabilitação
Vibração
[Mh] Termos MeSH secundário: Adulto
Doença Crônica
Seres Humanos
Perna (Membro)/inervação
Perna (Membro)/fisiopatologia
Masculino
Meia-Idade
Músculo Esquelético/inervação
Músculo Esquelético/fisiopatologia
Traumatismos da Medula Espinal/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170320
[St] Status:MEDLINE


  6 / 2404 MEDLINE  
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[PMID]:28258435
[Au] Autor:Mrachacz-Kersting N; Geertsen SS; Stevenson AJ; Nielsen JB
[Ad] Endereço:Department of Health Science and Technology, Center for Sensory-Motor Interaction (SMI), Aalborg University, Fredrik Bajers Vej 7 D-3, 9220, Aalborg, Denmark. nm@hst.aau.dk.
[Ti] Título:Convergence of ipsi- and contralateral muscle afferents on common interneurons mediating reciprocal inhibition of ankle plantarflexors in humans.
[So] Source:Exp Brain Res;235(5):1555-1564, 2017 May.
[Is] ISSN:1432-1106
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Recent studies have shown that afferents arising from muscle receptors located on one side can affect the activity of muscles on the contralateral side. In animal preparations, evidence supports that afferent pathways originating from one limb converge onto interneurons mediating disynaptic reciprocal Ia inhibition of the opposite limb. This study was designed to investigate whether this pathway is similar in humans to that described in animals. Thirteen healthy volunteers participated in one of two experiments. In experiment 1, the effects of ipsilateral posterior tibial nerve (iPTN) stimulation were assessed on the reciprocal Ia inhibition of the contralateral soleus (cSOL) motoneuronal pool (n = 8). Across all participants, iPTN stimulation intensity was 1.69 ± 0.3 × Motor Threshold (MT) and contralateral common peroneal (cCPN) stimulation intensity was 0.86 ± 0.16 × MT. iPTN and cCPN stimulation were delivered separately or in combination and changes in the ongoing electromyography (EMG) quantified. In experiment 2, the amplitude of a test SOL H-reflex elicited by contralateral PTN (cPTN) stimulation was quantified following iPTN, cCPN or iPTN + cCPN nerve stimulation (n = 5). Intensities used during the H-reflex conditioning experiment were 1.79 ± 0.4 × MT for the iPTN stimulation and 0.88 ± 0.16 × MT for cCPN stimulation. Across all participants, the onset of the cSOL EMG suppression was 42 ± 4, 44 ± 3 and 44 ± 3 ms for iPTN, cCPN and iPTN + cCPN conditions, respectively. The inhibition from the combined iPTN and cCPN stimulation was significantly greater compared to the algebraic sum of their separate effects. When conditioning the cSOL H-reflex, the ISI between the test cPTN and the iPTN or cCPN stimulus was 5.4 ± 0.5 and 2.6 ± 0.5, respectively. The combined stimulation induced a significantly greater inhibition compared to their separate effects. These data provide evidence of convergence on common inhibitory interneurons by muscle afferents activated by iPTN and cCPN stimulation during sitting. Since the inhibition elicited by cCPN stimulation is known to be mediated by the disynaptic Ia inhibitory pathway, this suggests that the crossed inhibition of cSOL motoneurones elicited by muscle afferents from the ipsilateral plantarflexor muscles is at least partly mediated by Ia inhibitory interneurons in the contralateral human spinal cord. This is similar to what has been observed in the cat.
[Mh] Termos MeSH primário: Tornozelo/fisiologia
Lateralidade Funcional/fisiologia
Reflexo H/fisiologia
Interneurônios/fisiologia
Músculo Esquelético/fisiologia
Inibição Neural/fisiologia
[Mh] Termos MeSH secundário: Adulto
Vias Aferentes
Análise de Variância
Estimulação Elétrica
Eletromiografia
Seres Humanos
Masculino
Contração Muscular/fisiologia
Nervo Tibial/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE
[do] DOI:10.1007/s00221-016-4871-6


  7 / 2404 MEDLINE  
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[PMID]:28225813
[Au] Autor:Dongés SC; D'Amico JM; Butler JE; Taylor JL
[Ad] Endereço:Neuroscience Research Australia, Barker Street, Randwick, New South Wales, Australia.
[Ti] Título:The effects of cervical transcutaneous spinal direct current stimulation on motor pathways supplying the upper limb in humans.
[So] Source:PLoS One;12(2):e0172333, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Non-invasive, weak direct current stimulation can induce changes in excitability of underlying neural tissue. Many studies have used transcranial direct current stimulation to induce changes in the brain, however more recently a number of studies have used transcutaneous spinal direct current stimulation to induce changes in the spinal cord. This study further characterises the effects following cervical transcutaneous spinal direct current stimulation on motor pathways supplying the upper limb. In Study 1, on two separate days, participants (n = 12, 5 F) received 20 minutes of either real or sham direct current stimulation at 3 mA through electrodes placed in an anterior-posterior configuration over the neck (anode anterior). Biceps brachii, flexor carpi radialis and first dorsal interosseous responses to transcranial magnetic stimulation (motor evoked potentials) and cervicomedullary stimulation (cervicomedullary motor evoked potentials) were measured before and after real or sham stimulation. In Study 2, on two separate days, participants (n = 12, 7 F) received either real or sham direct current stimulation in the same way as for Study 1. Before and after real or sham stimulation, median nerve stimulation elicited M waves and H reflexes in the flexor carpi radialis. H-reflex recruitment curves and homosynaptic depression of the H reflex were assessed. Results show that the effects of real and sham direct current stimulation did not differ for motor evoked potentials or cervicomedullary motor evoked potentials for any muscle, nor for H-reflex recruitment curve parameters or homosynaptic depression. Cervical transcutaneous spinal direct current stimulation with the parameters described here does not modify motor responses to corticospinal stimulation nor does it modify H reflexes of the upper limb. These results are important for the emerging field of transcutaneous spinal direct current stimulation.
[Mh] Termos MeSH primário: Vias Eferentes/fisiologia
Potencial Evocado Motor/fisiologia
Estimulação da Medula Espinal/métodos
Estimulação Elétrica Nervosa Transcutânea/métodos
Extremidade Superior/inervação
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Reflexo H/fisiologia
Seres Humanos
Masculino
Nervo Mediano/fisiologia
Músculo Esquelético/fisiologia
Estimulação Magnética Transcraniana
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172333


  8 / 2404 MEDLINE  
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[PMID]:28182676
[Au] Autor:Ryu Y; Ogata T; Nagao M; Kitamura T; Morioka K; Ichihara Y; Doi T; Sawada Y; Akai M; Nishimura R; Fujita N
[Ad] Endereço:Department of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
[Ti] Título:The swimming test is effective for evaluating spasticity after contusive spinal cord injury.
[So] Source:PLoS One;12(2):e0171937, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Spasticity is a frequent chronic complication in individuals with spinal cord injury (SCI). However, the severity of spasticity varies in patients with SCI. Therefore, an evaluation method is needed to determine the severity of spasticity. We used a contusive SCI model that is suitable for clinical translation. In this study, we examined the feasibility of the swimming test and an EMG for evaluating spasticity in a contusive SCI rat model. Sprague-Dawley rats received an injury at the 8th thoracic vertebra. Swimming tests were performed 3 to 6 weeks after SCI induction. We placed the SCI rats into spasticity-strong or spasticity-weak groups based on the frequency of spastic behavior during the swimming test. Subsequently, we recorded the Hoffman reflex (H-reflex) and examined the immunoreactivity of serotonin (5-HT) and its receptor (5-HT2A) in the spinal tissues of the SCI rats. The spasticity-strong group had significantly decreased rate-dependent depression of the H-reflex compared to the spasticity-weak group. The area of 5-HT2A receptor immunoreactivity was significantly increased in the spasticity-strong group. Thus, both electrophysiological and histological evaluations indicate that the spasticity-strong group presented with a more severe upper motor neuron syndrome. We also observed the groups in their cages for 20 hours. Our results suggest that the swimming test provides an accurate evaluation of spasticity in this contusive SCI model. We believe that the swimming test is an effective method for evaluating spastic behaviors and developing treatments targeting spasticity after SCI.
[Mh] Termos MeSH primário: Espasticidade Muscular/fisiopatologia
Traumatismos da Medula Espinal/fisiopatologia
Natação
[Mh] Termos MeSH secundário: Animais
Feminino
Reflexo H
Neurônios Motores/metabolismo
Neurônios Motores/fisiologia
Espasticidade Muscular/etiologia
Espasticidade Muscular/patologia
Ratos
Ratos Sprague-Dawley
Receptor 5-HT2A de Serotonina/metabolismo
Traumatismos da Medula Espinal/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptor, Serotonin, 5-HT2A)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170210
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0171937


  9 / 2404 MEDLINE  
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[PMID]:28093306
[Au] Autor:Gray WA; Sabatier MJ; Kesar TM; Borich MR
[Ad] Endereço:Division of Physical Therapy, Department of Rehabilitation Medicine, Emory University,1441 Clifton Road NE, Atlanta, GA 30322 USA.
[Ti] Título:Establishing between-session reliability of TMS-conditioned soleus H-reflexes.
[So] Source:Neurosci Lett;640:47-52, 2017 Feb 15.
[Is] ISSN:1872-7972
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Transcranial magnetic stimulation (TMS) of the primary motor cortex (M1) can be used to evaluate descending corticomotor influences on spinal reflex excitability through modulation of the Hoffman reflex (H-reflex). The purpose of this study was to characterize between-session reliability of cortical, spinal, and cortical-conditioned spinal excitability measures collected from the soleus muscle. Thirteen able-bodied young adult participants were tested over four sessions. Intraclass correlation coefficients were calculated to quantify between-session reliability of active motor threshold (AMT), unconditioned H-reflexes (expressed as a percentage of M ), and conditioned H-reflexes using short-latency facilitation (SLF) and long-latency facilitation (LLF). Pearson correlation coefficients were calculated to assess associations between H-reflex facilitation and unconditioned H-reflex amplitude. Between-session reliability for SLF (ICC=0.71) was higher than for LLF (ICC=0.45), was excellent for AMT (ICC=0.95), and was moderate for unconditioned H-reflexes (ICC=0.63). Our results suggest moderate-to-good reliability of SLF and LLF to evaluate cortical influences on spinal reflex excitability across multiple testing sessions in able-bodied individuals.
[Mh] Termos MeSH primário: Reflexo H
Córtex Motor/fisiologia
Músculo Esquelético/inervação
Medula Espinal/fisiologia
[Mh] Termos MeSH secundário: Adulto
Eletromiografia
Seres Humanos
Perna (Membro)/inervação
Neurônios Motores/fisiologia
Psicometria
Reprodutibilidade dos Testes
Nervo Tibial/fisiologia
Estimulação Magnética Transcraniana
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE


  10 / 2404 MEDLINE  
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[PMID]:28039767
[Au] Autor:Fox A; Koceja D
[Ad] Endereço:Indiana University, 1025 E. 7th St, Bloomington, IN 47405, United States. Electronic address: Apollonia.Fox@va.gov.
[Ti] Título:Static otolithic drive alters presynaptic inhibition in soleus motor pool.
[So] Source:J Electromyogr Kinesiol;32:37-43, 2017 Feb.
[Is] ISSN:1873-5711
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The vestibular system has both direct and indirect connections to the soleus motor pool via the vestibulospinal and reticulospinal tracts. The exact nature of how this vestibular information is integrated within the spinal cord is largely unknown. The purpose of this study was to identify whether changes in static otolithic drive altered the amount of presynaptic inhibition in the soleus H-reflex pathway. Changes in static otolithic drive were investigated in sixteen healthy participants using a tilt table. Two presynaptic pathways (common peroneal and femoral) to the soleus H-reflex were tested in three weight conditions (supine, non-weight bearing, and weight bearing). The dependent variable was the peak-to-peak amplitude of the soleus H-reflex. Inhibition to the soleus motor pool through the common peroneal nerve pathway differed significantly during weight conditions and tilt. During tilt and non-weight bearing there was greater inhibition of the soleus H-reflex compared to supine, however, this effect was reversed during tilt and weight bearing. Facilitation from the femoral nerve pathway was reduced by tilt compared to supine, but this reduction was unaffected by weight condition. This supports a role of the vestibular system as providing complex, task-dependent presynaptic input to motoneurons in the lower limbs.
[Mh] Termos MeSH primário: Neurônios Motores/fisiologia
Músculo Esquelético/fisiologia
Inibição Neural
Vestíbulo do Labirinto/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Nervo Femoral/fisiologia
Reflexo H
Decúbito Inclinado com Rebaixamento da Cabeça
Seres Humanos
Extremidade Inferior/inervação
Extremidade Inferior/fisiologia
Masculino
Músculo Esquelético/inervação
Nervo Fibular/fisiologia
Medula Espinal/fisiologia
Suporte de Carga
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170101
[St] Status:MEDLINE



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